Long non-coding RNA LINC00520 promotes the proliferation and metastasis of malignant melanoma by inducing the miR-125b-5p/EIF5A2 axis
Long intergenic non-protein coding RNA 520 (LINC00520), a novel identified lncRNA, has been shown to modulate the malignant phenotype of tumor cells in some malignant tumors. However, the exact role and molecu... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 28, 2020 Category: Cancer & Oncology Authors: Wenkang Luan, Yuting Ding, Haitao Yuan, Shaojun Ma, Hongru Ruan, Jinlong Wang, Feng Lu and Xuefeng Bu Tags: Research Source Type: research

Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples
In a large number of cancer types, treatment selection depends on the presence of specific tumor biomarkers. Due to the dynamic nature of cancer, very often these predictive biomarkers are not uniformly presen... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 27, 2020 Category: Cancer & Oncology Authors: Marco Russano, Andrea Napolitano, Giulia Ribelli, Michele Iuliani, Sonia Simonetti, Fabrizio Citarella, Francesco Pantano, Emanuela Dell ’Aquila, Cecilia Anesi, Nicola Silvestris, Antonella Argentiero, Antonio Solimando, Bruno Vincenzi, Giuseppe Tonini Tags: Review Source Type: research

Circ_0008532 promotes bladder cancer progression by regulation of the miR-155-5p/miR-330-5p/MTGR1 axis
Circular RNAs (circRNAs) have been associated with bladder cancer (BC), but the specific underlying molecular mechanism of their association with BC development has not been fully explored. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 27, 2020 Category: Cancer & Oncology Authors: Liang Chen, Xiong Yang, Jun Zhao, Ming Xiong, Raya Almaraihah, Zhaohui Chen and Teng Hou Tags: Research Source Type: research

TFEB-NF- κB inflammatory signaling axis: a novel therapeutic pathway of Dihydrotanshinone I in doxorubicin-induced cardiotoxicity
Doxorubicin is effective in a variety of solid and hematological malignancies. Unfortunately, clinical application of doxorubicin is limited due to a cumulative dose-dependent cardiotoxicity. Dihydrotanshinone... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 24, 2020 Category: Cancer & Oncology Authors: Xiaoping Wang, Qiyan Wang, Weili Li, Qian Zhang, Yanyan Jiang, Dongqing Guo, Xiaoqian Sun, Wenji Lu, Chun Li and Yong Wang Tags: Research Source Type: research

RNA-binding protein MSI2 isoforms expression and regulation in progression of triple-negative breast cancer
The RNA-binding protein Musashi-2 (MSI2) has been implicated in the tumorigenesis and tumor progression of some human cancers. MSI2 has also been reported to suppress tumor epithelial-to-mesenchymal transition... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 24, 2020 Category: Cancer & Oncology Authors: Ming Li, An-qi Li, Shu-ling Zhou, Hong Lv, Ping Wei and Wen-tao Yang Tags: Research Source Type: research

The circular RNA 001971/miR-29c-3p axis modulates colorectal cancer growth, metastasis, and angiogenesis through VEGFA
Colorectal cancer (CRC) is one of the most common malignant tumors globally. Angiogenesis is a key event maintaining tumor cell survival and aggressiveness. The expression of vascular endothelial growth factor... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 19, 2020 Category: Cancer & Oncology Authors: Chen Chen, Zhiguo Huang, Xiaoye Mo, Yanmin Song, Xiangmin Li, Xiaogang Li and Mu Zhang Tags: Research Source Type: research

ABCA8 is regulated by miR-374b-5p and inhibits proliferation and metastasis of hepatocellular carcinoma through the ERK/ZEB1 pathway
ATP binding cassette subfamily A member 8 (ABCA8) belongs to the ATP binding cassette (ABC) transporter superfamily. ABCA8 is a transmembrane transporter responsible for the transport of organics, such as chol... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 19, 2020 Category: Cancer & Oncology Authors: Yifeng Cui, Shuhang Liang, Shugeng Zhang, Congyi Zhang, Yunzheng Zhao, Dehai Wu, Jiabei Wang, Ruipeng Song, Jizhou Wang, Dalong Yin, Yao Liu, Shangha Pan, Xirui Liu, Yan Wang, Jihua Han, Fanzheng Meng & hellip; Tags: Research Source Type: research

Relevance of immune cell and tumor microenvironment imaging in the new era of immunotherapy
Tumor-infiltrating immune cells play a key role against cancer. However, malignant cells are able to evade the immune response and establish a very complex balance in which different immune subtypes may drive ... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 18, 2020 Category: Cancer & Oncology Authors: Filippo Galli, Jesus Vera Aguilera, Belinda Palermo, Svetomir N. Markovic, Paola Nistic ò and Alberto Signore Tags: Review Source Type: research

Promotion of ubiquitination-dependent survivin destruction contributes to xanthohumol-mediated tumor suppression and overcomes radioresistance in human oral squamous cell carcinoma
Overexpression of survivin plays a crucial role in tumorigenesis and correlates with poor prognosis in human malignancies. Thus, survivin has been proposed as an attractive target for new anti-tumor interventi... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 14, 2020 Category: Cancer & Oncology Authors: Ming Li, Feng Gao, Xinfang Yu, Qing Zhao, Li Zhou, Wenbin Liu and Wei Li Tags: Research Source Type: research

Drug repurposing against COVID-19: focus on anticancer agents
The very limited time allowed to face the COVID-19 pandemic poses a pressing challenge to find proper therapeutic approaches. However, synthesis and full investigation from preclinical studies to phase III tri... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 12, 2020 Category: Cancer & Oncology Authors: Gennaro Ciliberto, Rita Mancini and Marco G. Paggi Tags: Review Source Type: research

A novel bispecific antibody targeting CD3 and prolactin receptor (PRLR) against PRLR-expression breast cancer
Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown ... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 12, 2020 Category: Cancer & Oncology Authors: Yuexian Zhou, Huifang Zong, Lei Han, Yueqing Xie, Hua Jiang, John Gilly, Baohong Zhang, Huili Lu, Jie Chen, Rui Sun, Zhidi Pan and Jianwei Zhu Tags: Research Source Type: research

Different p53 genotypes regulating different phosphorylation sites and subcellular location of CDC25C associated with the formation of polyploid giant cancer cells
Our previous studies have confirmed that cobalt chloride (CoCl2) can induce the formation of polyploid giant cancer cells (PGCCs), which is the key to the heterogeneity of solid tumors. PGCC formation is closely ... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 11, 2020 Category: Cancer & Oncology Authors: Kai Liu, Minying Zheng, Qi Zhao, Kexin Zhang, Zugui Li, Fangmei Fu, Hao Zhang, Jiaxing Du, Yuwei Li and Shiwu Zhang Tags: Research Source Type: research

EVI5 is an oncogene that regulates the proliferation and metastasis of NSCLC cells
The Ecotropic viral integration site 5 (EVI5), an important protein in regulating cell cycle, cytokinesis and cellular membrane traffic, functions as a stabilizing factor maintaining anaphase-promoting complex... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 11, 2020 Category: Cancer & Oncology Authors: Tingting Cai, Jieqi Zhou, Yuanyuan Zeng, Wenwen Du, Yang Zhang, Ting Liu, Yulong Fu, Jian-an Huang, Qian Qian, Jianjie Zhu, Chunhua Ling and Zeyi Liu Tags: Research Source Type: research

ULK1 inhibition as a targeted therapeutic strategy for FLT3-ITD-mutated acute myeloid leukemia
In acute myeloid leukemia (AML), internal tandem duplication mutations in the FLT3 tyrosine kinase receptor (FLT3-ITD) are associated with a dismal outcome. Although uncoordinated 51-like kinase 1 (ULK1), whic... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 11, 2020 Category: Cancer & Oncology Authors: Doh Yu Hwang, Ju-In Eom, Ji Eun Jang, Hoi-Kyung Jeung, Haerim Chung, Jin Seok Kim, June-Won Cheong and Yoo Hong Min Tags: Research Source Type: research

SNCG promotes the progression and metastasis of high-grade serous ovarian cancer via targeting the PI3K/AKT signaling pathway
The poor prognosis of patients with ovarian cancer is mainly due to cancer progression. γ-Synuclein (SNCG) has reported as a critical player in cancer metastasis. However, its biological roles and mechanism ar... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 7, 2020 Category: Cancer & Oncology Authors: Jing Zhang, Xiao-han Liu, Cong Li, Xiao-xing Wu, Yan-lin Chen, Wen-wen Li, Xian Li, Fan Gong, Qin Tang and Dan Jiang Tags: Research Source Type: research

Correction to: Long non-coding RNA PXN-AS1 suppresses pancreatic cancer progression by acting as a competing endogenous RNA of miR-3064 to upregulate PIP4K2B expression
In the original publication of this manuscript [1], there are errors in Fig. 3. The authors declare that the identified errors do not change the results or conclusions of this paper. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 7, 2020 Category: Cancer & Oncology Authors: Jiayan Yan, Yunxi Jia, Han Chen, Wei Chen and Xiaoying Zhou Tags: Correction Source Type: research

SH3BGRL confers innate drug resistance in breast cancer by stabilizing HER2 activation on cell membrane
HER2-positive breast cancer is usually associated to the more aggressive progression and the worse prognosis, but the mechanism underlying the innate resistance to HER2-targeted therapy remains elusive. The sc... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 7, 2020 Category: Cancer & Oncology Authors: Hui Li, Mingming Zhang, Yanli Wei, Farhan Haider, Yitong Lin, Wen Guan, Yanbin Liu, Shaoyang Zhang, Ronghua Yuan, Xia Yang, Shulan Yang and Haihe Wang Tags: Research Source Type: research

Sur-X, a novel peptide, kills colorectal cancer cells by targeting survivin-XIAP complex
Survivin and XIAP are two important members of the inhibitor of apoptosis protein family and have been considered as potential targets for cancer treatment due to their overexpression in large variety of cance... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 7, 2020 Category: Cancer & Oncology Authors: Wanxia Fang, Xiaofang Che, Guohui Li, Anhui Wang, Yizhe Wang, Xiaonan Shi, Kezuo Hou, Xiaojie Zhang, Xiujuan Qu and Yunpeng Liu Tags: Research Source Type: research

Novel therapeutic strategies targeting telomere maintenance mechanisms in high-risk neuroblastoma
The majority of high-risk neuroblastomas can be divided into three distinct molecular subgroups defined by the presence of MYCN amplification, upstream TERT rearrangements or alternative lengthening of telomeres ... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 6, 2020 Category: Cancer & Oncology Authors: S. L. George, V. Parmar, F. Lorenzi, L. V. Marshall, Y. Jamin, E. Poon, P. Angelini and L. Chesler Tags: Review Source Type: research

Downregulation of GLYR1 contributes to microsatellite instability colorectal cancer by targeting p21 via the p38MAPK and PI3K/AKT pathways
GLYR1 has a high mutation frequency in microsatellite instability colorectal cancer (MSI CRC) and is presumed to be a novel tumor suppressor. However, the role of GLYR1 in tumors has never been studied. In par... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 5, 2020 Category: Cancer & Oncology Authors: Zhiyan Hu, Ting Long, Yidan Ma, Jiaxian Zhu, Lingfang Gao, Yan Zhong, Xia Wang, Xiaoyan Wang and Zuguo Li Tags: Research Source Type: research

Extended half-life target module for sustainable UniCAR T-cell treatment of STn-expressing cancers
Adapter chimeric antigen receptor (CAR) approaches have emerged has promising strategies to increase clinical safety of CAR T-cell therapy. In the UniCAR system, the safety switch is controlled via a target mo... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 5, 2020 Category: Cancer & Oncology Authors: Liliana R. Loureiro, Anja Feldmann, Ralf Bergmann, Stefanie Koristka, Nicole Berndt, Domokos M áthé, Nikolett Hegedüs, Krisztián Szigeti, Paula A. Videira, Michael Bachmann and Claudia Arndt Tags: Research Source Type: research

Mimicking tumor hypoxia and tumor-immune interactions employing three-dimensional in vitro models
The heterogeneous tumor microenvironment (TME) is highly complex and not entirely understood. These complex configurations lead to the generation of oxygen-deprived conditions within the tumor niche, which mod... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 1, 2020 Category: Cancer & Oncology Authors: Somshuvra Bhattacharya, Kristin Calar and Pilar de la Puente Tags: Review Source Type: research

Cancer at the time of the COVID-19 hurricane
(Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 29, 2020 Category: Cancer & Oncology Authors: Giovanni Blandino Tags: Commentary Source Type: research

Correction to: LncRNA AFAP1-AS1 promotes tumorigenesis and epithelial-mesenchymal transition of osteosarcoma through RhoC/ROCK1/p38MAPK/Twist1 signaling pathway
In the original publication of this manuscript [1], Fig. 5a needs to be revised, and adjustments have also been made to the captions for Figs. 2, 4, 5 and S1 to improve clarity for the reader. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 28, 2020 Category: Cancer & Oncology Authors: Deyao Shi, Fashuai Wu, Shidai Mu, Binwu Hu, Binlong Zhong, Feng Gao, Xiangcheng Qing, Jianxiang Liu, Zhicai Zhang and Zengwu Shao Tags: Correction Source Type: research

CPI-613 rewires lipid metabolism to enhance pancreatic cancer apoptosis via the AMPK-ACC signaling
Pancreatic cancer remains one of the most rapidly progressive and deadly malignancies worldwide. Current treatment regimens only result in small improvements in overall survival for patients with this cancer t... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 28, 2020 Category: Cancer & Oncology Authors: Lixia Gao, Zhigang Xu, Zheng Huang, Yan Tang, Donglin Yang, Jiuhong Huang, Leilei He, Manran Liu, Zhongzhu Chen and Yong Teng Tags: Research Source Type: research

miR-615-3p promotes the epithelial-mesenchymal transition and metastasis of breast cancer by targeting PICK1/TGFBRI axis
Increasing evidence indicates that epithelial-mesenchymal transition (EMT) can be regulated by microRNAs (miRNAs). miR-615-3p was shown to be involved in tumor development. However, the role of miR-615-3p in t... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 26, 2020 Category: Cancer & Oncology Authors: Bo Lei, Dandan Wang, Ming Zhang, Yuwei Deng, Huijie Jiang and Yiwen Li Tags: Research Source Type: research

A novel ETV6-miR-429-CRKL regulatory circuitry contributes to aggressiveness of hepatocellular carcinoma
Tumor metastasis is one of the main causes of the high mortality of hepatocellular carcinoma (HCC). E-Twenty Six variant gene 6 (ETV6) is a strong transcriptional repressor, associated with the development and... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 23, 2020 Category: Cancer & Oncology Authors: Chunmei Guo, Chao Gao, Dongting Zhao, Jiahui Li, Jinxia Wang, Xujuan Sun, Qinlong Liu, Lihong Hao, Frederick T. Greenaway, Yuxiang Tian, Shuqing Liu and Ming-Zhong Sun Tags: Research Source Type: research

Cross-sectional analysis of circulating tumor DNA in primary colorectal cancer at surgery and during post-surgery follow-up by liquid biopsy
Liquid biopsy (LB) in early-stage, non-metastatic colorectal cancer (CRC) must be sensitive enough to detect extremely low circulating tumor DNA (ctDNA) levels. This challenge has been seldom and non-systemati... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 20, 2020 Category: Cancer & Oncology Authors: Matteo Allegretti, Giuliano Cottone, Fabio Carboni, Ettore Cotroneo, Beatrice Casini, Elena Giordani, Carla Azzurra Amoreo, Simonetta Buglioni, Maria Diodoro, Edoardo Pescarmona, Settimio Zazza, Orietta Federici, Massimo Zeuli, Laura Conti, Giovanni Cigli Tags: Research Source Type: research

Urinary expression of let-7c cluster as non-invasive tool to assess the risk of disease progression in patients with high grade non-muscle invasive bladder Cancer: a pilot study
High grade non-muscle-invasive bladder cancer (HG-NMIBC) is a heterogeneous disease with variable risk of progression. Urinary microRNAs are promising biomarkers for BC detection and surveillance. Let-7c-5p mi... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 17, 2020 Category: Cancer & Oncology Authors: Manuela Spagnuolo, Manuela Costantini, Mariaconsiglia Ferriero, Marco Varmi, Isabella Sperduti, Giulia Regazzo, Lucia Cicchillitti, Ana Bel én Díaz Méndez, Giovanni Cigliana, Vincenzo Pompeo, Andrea Russo, Valentina Laquintana, Riccardo Mastroianni, Gi Tags: Research Source Type: research

Exosomal miRNAs in tumor microenvironment
Tumor microenvironment (TME) is the internal environment in which tumor cells survive, consisting of tumor cells, fibroblasts, endothelial cells, and immune cells, as well as non-cellular components, such as e... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 16, 2020 Category: Cancer & Oncology Authors: Shiming Tan, Longzheng Xia, Pin Yi, Yaqian Han, Lu Tang, Qing Pan, Yutong Tian, Shan Rao, Linda Oyang, Jiaxin Liang, Jinguan Lin, Min Su, Yingrui Shi, Deliang Cao, Yujuan Zhou and Qianjin Liao Tags: Review Source Type: research

Long non-coding RNA NCK1-AS1 promotes the tumorigenesis of glioma through sponging microRNA-138-2-3p and activating the TRIM24/Wnt/ β-catenin axis
This study was conducted to probe the role of long noncoding RNA... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 15, 2020 Category: Cancer & Oncology Authors: Lifa Huang, Xu Li, Hui Ye, Yajun Liu, Xiaolong Liang, Chao Yang, Lin Hua, Zhaoxian Yan and Xin Zhang Tags: Research Source Type: research

Norepinephrine-stimulated HSCs secrete sFRP1 to promote HCC progression following chronic stress via augmentation of a Wnt16B/ β-catenin positive feedback loop
Sustained adrenergic signaling secondary to chronic stress promotes cancer progression; however, the underlying mechanisms for this phenomenon remain unclear. Hepatocellular carcinoma (HCC) frequently develops... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 15, 2020 Category: Cancer & Oncology Authors: Xia-Hui Lin, Hua-Hua Liu, Shu-Jung Hsu, Rui Zhang, Jie Chen, Jun Chen, Dong-Mei Gao, Jie-Feng Cui, Zheng-Gang Ren and Rong-Xin Chen Tags: Research Source Type: research

Exosome-mediated transfer of miR-93-5p from cancer-associated fibroblasts confer radioresistance in colorectal cancer cells by downregulating FOXA1 and upregulating TGFB3
Cancer-associated fibroblasts (CAFs) have been intensively studied in recent studies with aims of finding more concrete evidence on their mechanism of involvement in tumor progression, which is currently unkno... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 15, 2020 Category: Cancer & Oncology Authors: Xijuan Chen, Junqi Liu, Qinglan Zhang, Baoxing Liu, Yan Cheng, Yonglei Zhang, Yanan Sun, Hong Ge and Yingqiang Liu Tags: Research Source Type: research

PERK/NRF2 and autophagy form a resistance mechanism against G9a inhibition in leukemia stem cells
The histone methyltransferase G9a has recently been identified as a potential target for epigenetic therapy of acute myeloid leukemia (AML). However, the effect of G9a inhibition on leukemia stem cells (LSCs),... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 15, 2020 Category: Cancer & Oncology Authors: Ji Eun Jang, Ju-In Eom, Hoi-Kyung Jeung, Haerim Chung, Yu Ri Kim, Jin Seok Kim, June-Won Cheong and Yoo Hong Min Tags: Research Source Type: research

Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer
Epidermal growth factor receptor (EGFR) activating mutations play crucial roles in the tumorigenesis of human non-small cell lung cancer (NSCLC). The mechanism regarding how EGFR signaling regulates myeloid ce... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 10, 2020 Category: Cancer & Oncology Authors: Xinyou Yu, Feng Gao, Wei Li, Li Zhou, Wenbin Liu and Ming Li Tags: Research Source Type: research

Molecular interplay between linc01134 and YY1 dictates hepatocellular carcinoma progression
Revealing the mechanical role of long non-coding RNAs (lncRNAs) in tumorigenesis can contribute to novel therapeutic target for cancers. The regulatory role of linc01134 in hepatocellular carcinoma (HCC) has n... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 9, 2020 Category: Cancer & Oncology Authors: Zhonghou Rong, Zhiyi Wang, Xinxing Wang, Chengkun Qin and Wenmao Geng Tags: Research Source Type: research

Correction to: Down-regulated lncRNA SBF2-AS1 inhibits tumorigenesis and progression of breast cancer by sponging microRNA-143 and repressing RRS1
In the original publication of this manuscript [1], RRS1 stands for ‘Ribosome biogenesis regulatory protein homolog’ instead of ‘resistance to ralstonia solanacearum 1’. This mistake appears 4 times in the man... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 7, 2020 Category: Cancer & Oncology Authors: Wenfei Xia, Yun Liu, Teng Cheng, Tao Xu, Menglu Dong and Xiaopeng Hu Tags: Correction Source Type: research

Cullin-7 (CUL7) is overexpressed in glioma cells and promotes tumorigenesis via NF- κB activation
Cullin-7 (CUL7) is a member of the DOC domain-containing cullin family and is involved in the regulation of cell transformation. However, the clinical significance, potential mechanism and upstream regulators ... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 6, 2020 Category: Cancer & Oncology Authors: Jianye Xu, Zongpu Zhang, Mingyu Qian, Shaobo Wang, Wei Qiu, Zihang Chen, Zhongzheng Sun, Ye Xiong, Chaochao Wang, Xiaopeng Sun, Rongrong Zhao, Hao Xue and Gang Li Tags: Research Source Type: research

Circular RNA hsa_circ_0000326 acts as a miR-338-3p sponge to facilitate lung adenocarcinoma progression
Circular RNAs (circRNAs) are a novel class of noncoding RNAs that regulate gene expression at the transcriptional or posttranscriptional level. According to recent studies, circRNAs are involved in the pathoge... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 5, 2020 Category: Cancer & Oncology Authors: Yuzhu Xu, Jun Yu, Zhenli Huang, Bohua Fu, Yu Tao, Xuefei Qi, Yong Mou, Yinan Hu, Yi Wang, Yong Cao, Dingsheng Jiang, Jungang Xie, Yongjian Xu, Jianping Zhao and Weining Xiong Tags: Research Source Type: research

Long noncoding RNA HOST2, working as a competitive endogenous RNA, promotes STAT3-mediated cell proliferation and migration via decoying of let-7b in triple-negative breast cancer
Human ovarian cancer specific transcript 2 (HOST2) is a long non-coding RNA (lncRNA) reported to be specifically high expressed in human ovarian cancer. However, the mechanism that how HOST2 regulates triple n... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 5, 2020 Category: Cancer & Oncology Authors: Kaiyao Hua, Xiaochong Deng, Jiashu Hu, Changle Ji, Yunhe Yu, Jiayi Li, Xuehui Wang and Lin Fang Tags: Research Source Type: research

Correction to: Hsa_circ_0058124 promotes papillary thyroid cancer tumorigenesis and invasiveness through the NOTCH3/GATAD2A axis
In the original publication of this manuscript [1], the Fig. 6a invasion si-hsa_circ_0058124_2# group (row 2 right and row 3 right) and Fig. 9c TPC-1 clone formation assay control group (row 1 left) were mispl... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 1, 2020 Category: Cancer & Oncology Authors: Yao Yao, Xinyuan Chen, Hong Yang, Wei Chen, Yichun Qian, Zhongyi Yan, Tian Liao, Weiping Yao, Wenlan Wu, Tonghua Yu, Yun Chen and Yuan Zhang Tags: Correction Source Type: research

circFOXM1 promotes proliferation of non-small cell lung carcinoma cells by acting as a ceRNA to upregulate FAM83D
Biological role and clinical significance of circular RNAs (circRNAs) remain largely unknown. Herein, we aimed to investigate biological function, molecular mechanism, and clinical significance of a circular R... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - March 30, 2020 Category: Cancer & Oncology Authors: Chengtao Yu, Zhuoan Cheng, Shaohua Cui, Xiaowei Mao, Botai Li, Yujie Fu, Hui Wang, Haojie Jin, Qing Ye, Xiaojing Zhao, Liyan Jiang and Wenxin Qin Tags: Research Source Type: research

Exosomal MALAT1 sponges miR-26a/26b to promote the invasion and metastasis of colorectal cancer via FUT4 enhanced fucosylation and PI3K/Akt pathway
Exosomes are vesicles of endocytic origin released by various cell types and emerging as important mediators in tumor cells. Human metastases-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - March 24, 2020 Category: Cancer & Oncology Authors: Jingchao Xu, Yang Xiao, Bing Liu, Shimeng Pan, Qianqian Liu, Yujia Shan, Shuangda Li, Yu Qi, Yiran Huang and Li Jia Tags: Research Source Type: research

Oncogenic and drug-sensitive RET mutations in human epithelial ovarian cancer
Epithelial ovarian cancer (EOC) is a highly lethal malignancy. Improvement in genetic characterization of EOC patients is required to propose new potential targets, since surgical resection coupled to chemothe... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - March 23, 2020 Category: Cancer & Oncology Authors: Luyao Guan, Zhang Li, Feifei Xie, Yuzhi Pang, Chenyun Zhang, Haosha Tang, Hao Zhang, Chun Chen, Yaying Zhan, Ting Zhao, Hongyuan Jiang, Xiaona Jia, Yuexiang Wang and Yuan Lu Tags: Research Source Type: research

Runt-related transcription factor 1 promotes apoptosis and inhibits neuroblastoma progression in vitro and in vivo
Runt-related transcription factor 1 (RUNX1) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters and can accelerate apoptosis in various tumors. However, the r... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - March 20, 2020 Category: Cancer & Oncology Authors: Mei Hong, Jing He, Duo Li, Yuanyuan Chu, Jiarui Pu, Qiangsong Tong, Harish C. Joshi, Shaotao Tang and Shiwang Li Tags: Research Source Type: research

Dissecting the transcriptional regulatory networks of promoter-associated noncoding RNAs in development and cancer
In-depth analysis of global RNA sequencing has enabled a comprehensive overview of cellular transcriptomes and revealed the pervasive transcription of divergent RNAs from promoter regions across eukaryotic gen... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - March 17, 2020 Category: Cancer & Oncology Authors: Lidia Chellini, Valentina Frezza and Maria Paola Paronetto Tags: Review Source Type: research

Reversal of ABCB1-related multidrug resistance by ERK5-IN-1
Inhibition of ABC transporters is considered the most effective way to circumvent multidrug resistance (MDR). In the present study, we evaluated the MDR modulatory potential of ERK5-IN-1, a potent extracelluar... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - March 12, 2020 Category: Cancer & Oncology Authors: Fang Wang, Delan Li, ZongHeng Zheng, Kenneth Kin Wah To, Zhen Chen, Mengjun Zhong, Xiaodong Su, Likun Chen and Liwu Fu Tags: Research Source Type: research

Genetic and pharmacological targeting of A2a receptor improves function of anti-mesothelin CAR T cells
CAR T cell-based therapies have shown promising results in hematological malignancies. Results of CAR T cell projects in solid tumors have been less impressive, and factors including lack of targetable antigen... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - March 10, 2020 Category: Cancer & Oncology Authors: Elham Masoumi, Leila Jafarzadeh, Hamid Reza Mirzaei, Khadijeh Alishah, Keyvan Fallah-Mehrjardi, Hosein Rostamian, Mohammad Khakpoor-Koosheh, Reza Meshkani, Farshid Noorbakhsh and Jamshid Hadjati Tags: Research Source Type: research

From single gene analysis to single cell profiling: a new era for precision medicine
Molecular profiling of DNA and RNA has provided valuable new insights into the genetic basis of non-malignant and malignant disorders, as well as an increased understanding of basic mechanisms that regulate hu... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - March 5, 2020 Category: Cancer & Oncology Authors: Maria Teresa Di Martino, Stefania Meschini, Katia Scotlandi, Chiara Riganti, Enrico De Smaele, Francesca Zazzeroni, Massimo Donadelli, Carlo Leonetti and Michele Caraglia Tags: Meeting Report Source Type: research

Variants of uncertain significance in the era of high-throughput genome sequencing: a lesson from breast and ovary cancers
The promising expectations about personalized medicine have opened the path to routine large-scale sequencing and increased the importance of genetic counseling for hereditary cancers, among which hereditary b... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - March 4, 2020 Category: Cancer & Oncology Authors: Giulia Federici and Silvia Soddu Tags: Review Source Type: research