Bilateral ovarian metastasis of clear-cell renal cell carcinoma: A case report.
Abstract Renal cell carcinoma (RCC) accounts for 2-3% of all adult malignancies. Clear-cell type RCC is the most common type, accounting for approximately 75% of all renal cancer cases. The most common sites of metastasis include the lung, bone, and liver. Ovarian metastasis of RCC is an exceptionally rare occurrence with only 41 cases reported in the literature with only 11 of these cases involving the bilateral ovaries. Here we present a case of clear-cell RCC arising from the left kidney with metastatic involvement of bilateral ovaries in a 48-year-old woman. PMID: 32707410 [PubMed - indexed for MEDLINE] (...
Source: Clinical Lung Cancer - December 16, 2020 Category: Cancer & Oncology Authors: Snyder E, Tafti D, Zhao JM, Walker K, Schwope RB Tags: Clin Imaging Source Type: research

Pre-treatment CT imaging in stage IIIA lung cancer: Can we predict local recurrence after definitive chemoradiotherapy?
CONCLUSIONS: Pre-treatment CT features alone are limited in predicting locoregional recurrence. Larger studies using quantitative tools are needed to predict such outcomes. PMID: 32721848 [PubMed - indexed for MEDLINE] (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - December 16, 2020 Category: Cancer & Oncology Authors: Plodkowski AJ, Araujo-Filho JAB, Simmers CDA, Girshman J, Raj M, Zheng J, Rimner A, Ginsberg MS Tags: Clin Imaging Source Type: research

Percutaneous computed tomography guided biopsy of sub-solid pulmonary nodules: differentiating solid from ground glass components at the time of biopsy.
CONCLUSION: In most patients, the solid and ground glass components of a PSN were distinguishable when performing a CTGLB. In a minority of patients, discrepancy was noted between biopsy pathology and surgical pathology regarding the invasive nature of a nodule. PMID: 33059184 [PubMed - indexed for MEDLINE] (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - December 16, 2020 Category: Cancer & Oncology Authors: Halpenny D, Das K, Ziv E, Plodkowski A, Zheng J, Capanu M, Rekhtman N, Montecalvo J, Solomon SB, Ginsberg MS Tags: Clin Imaging Source Type: research

A population-based study of outcomes in patients with surgically resected non-small cell lung cancer with anaplastic lymphoma kinase-rearranged mutations: A matched-pair study.
Abstract The present study aimed to evaluate clinical outcomes in patients with surgically resected non-small cell lung cancer (NSCLC) with anaplastic lymphoma kinase (ALK)-rearranged mutations. A matched-pair analysis in completely resected ALK-rearranged NSLC patients and those with neither ALK nor epidermal growth factor receptor (EGFR) mutations diagnosed at 11 institutes was performed between April 2008 and March 2019. A total of 51 patients with surgically resected ALK-rearranged NSCLC were included. Women constituted 68.6%, and smokers 29.4%. The median age was 65 years. In matched-pair analysis, disease-fr...
Source: Clinical Lung Cancer - December 8, 2020 Category: Cancer & Oncology Authors: Inagaki M, Ichimura H, Usui S, Iguchi K, Ishibashi O, Nakamura R, Inage Y, Suzuki H, Kiyoshima M, Kamiyama K, Kimura M, Yoshida S, Sakai M, Kobayashi N, Furukawa K, Satoh H, Hizawa N, Sato Y Tags: Mol Clin Oncol Source Type: research

Differences in key genes in human alveolar macrophages between phenotypically normal smokers and nonsmokers: diagnostic and prognostic value in lung cancer.
CONCLUSION: DEGs, module, and hub genes identified in the present study help explain the effects of smoking on human alveolar macrophages and provide candidate targets for diagnosis and treatment of smoking-related lung cancer. PMID: 33284895 [PubMed - as supplied by publisher] (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - December 8, 2020 Category: Cancer & Oncology Authors: Wang YD, Li Z, Li FS Tags: Int J Clin Exp Pathol Source Type: research

Liquid biopsy for BRAF mutations testing in non-small cell lung cancer: a retrospective study.
Abstract V-Raf murine sarcoma viral oncogene homolog B (BRAF) gene mutations have recently been approved to select advanced stages non-small cell lung cancer (NSCLC) patients for tyrosine kinase inhibitors treatments. In this setting, liquid biopsy may represent a valuable option for BRAF mutational testing in patients without tissue availability. Here, we reviewed 196 plasma based liquid biopsies analysed by an in-house developed next generation sequencing panel, termed SiRe. On the overall, 6 (3.1%) out of 196 BRAF mutated cases were identified, with an overall median allelic frequency of 3.4%. Exon 15 p.V600E w...
Source: Clinical Lung Cancer - December 4, 2020 Category: Cancer & Oncology Authors: Iaccarino A, Pisapia P, Pepe F, Sgariglia R, Nacchio M, Russo G, Gragnano G, De Luca C, Troncone G, Malapelle U Tags: J Clin Pathol Source Type: research

Emerging impact of the long noncoding RNA MIR22HG on proliferation and apoptosis in multiple human cancers.
Abstract An increasing number of studies have shown that long noncoding RNAs (lncRNAs) play important roles in diverse cellular processes, including proliferation, apoptosis, migration, invasion, chromatin remodeling, metabolism and immune escape. Clinically, the expression of MIR22HG is increased in many human tumors (colorectal cancer, gastric cancer, hepatocellular carcinoma, lung cancer, and thyroid carcinoma), while in others (esophageal adenocarcinoma and glioblastoma), it is significantly decreased. Moreover, MIR22HG has been reported to function as a competitive endogenous RNA (ceRNA), be involved in signa...
Source: Clinical Lung Cancer - December 3, 2020 Category: Cancer & Oncology Authors: Zhang L, Li C, Su X Tags: J Exp Clin Cancer Res Source Type: research

An Automated knowledge-based planning routine for stereotactic body radiotherapy of peripheral lung tumors via DCA-based volumetric modulated arc therapy.
Abstract PURPOSE: To develop a knowledge-based planning (KBP) routine for stereotactic body radiotherapy (SBRT) of peripherally located early-stage non-small-cell lung cancer (NSCLC) tumors via dynamic conformal arc (DCA)-based volumetric modulated arc therapy (VMAT) using the commercially available RapidPlanTM software. This proposed technique potentially improves plan quality, reduces complexity, and minimizes interplay effect and small-field dosimetry errors associated with treatment delivery. METHODS: KBP model was developed and validated using 70 clinically treated high quality non-coplanar VMAT lung SBR...
Source: Clinical Lung Cancer - December 3, 2020 Category: Cancer & Oncology Authors: Visak J, Ge GY, McGarry RC, Randall M, Pokhrel D Tags: J Appl Clin Med Phys Source Type: research

Radiobiological effects of the interruption time with Monte Carlo Simulation on multiple fields in photon beams.
CONCLUSION: The ~10-min interruption of 6-MV photon beams did not significantly impact the radiobiological effectiveness, since the RBE decrease was
Source: Clinical Lung Cancer - December 3, 2020 Category: Cancer & Oncology Authors: Nakano H, Kawahara D, Tanabe S, Utsunomiya S, Takizawa T, Sakai M, Saito H, Ohta A, Kaidu M, Ishikawa H Tags: J Appl Clin Med Phys Source Type: research

Treatment patterns and clinical outcomes in patients with advanced non-small cell lung cancer initiating first-line treatment in the US community oncology setting: a real-world retrospective observational study.
CONCLUSION: These results suggest that real-world outcomes in this community oncology setting improved with the introduction of immuno-oncology therapies. However, clinical benefits are limited in certain subgroups and tend to be reduced compared with clinical trial observations. PMID: 33263865 [PubMed - as supplied by publisher] (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - December 2, 2020 Category: Cancer & Oncology Authors: Nadler E, Arondekar B, Aguilar KM, Zhou J, Chang J, Zhang X, Pawar V Tags: J Cancer Res Clin Oncol Source Type: research

HDAC2 inhibits EMT-mediated cancer metastasis by downregulating the long noncoding RNA H19 in colorectal cancer.
CONCLUSION: Our study supports HDAC2 as a CRC metastasis suppressor through the inhibition of EMT and the expression of H19 and MMP14. PMID: 33267897 [PubMed - in process] (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - December 2, 2020 Category: Cancer & Oncology Authors: Hu XT, Xing W, Zhao RS, Tan Y, Wu XF, Ao LQ, Li Z, Yao MW, Yuan M, Guo W, Li SZ, Yu J, Ao X, Xu X Tags: J Exp Clin Cancer Res Source Type: research

Prior Treatment for Non-small Cell Lung Cancer Is Associated With Improved Survival in Patients who Undergo Definitive Stereotactic Body Radiation Therapy for a Subsequent Lung Malignancy: A Retrospective Multivariate and Matched Pair Analysis.
Abstract BACKGROUND: Despite occurring commonly, the prognoses of second early-stage non-small cell lung cancers (NSCLC) are not well known. METHODS: The authors retrospectively reviewed the charts of inoperable patients who underwent thoracic stereotactic body radiation therapy (SBRT) from February 2007 to April 2019. Those with previous small cell lung cancers or SBRT treatments for tumors other than NSCLC were excluded. Multivariate Cox regression and a matched pair cohort analyses evaluated the prognoses of patients undergoing definitive SBRT for a new second primary. RESULTS: Of 438 patients who und...
Source: Clinical Lung Cancer - December 1, 2020 Category: Cancer & Oncology Authors: Farrugia MK, Jun S, Hennon MW, Nwogu CE, Dexter EU, Picone AL, Demmy TL, Gomez-Suescun JA, Fung-Kee-Fung S, Yendamuri SS, Singh AK Tags: Am J Clin Oncol Source Type: research

2017 Clinical practice guidelines for dyslipidemia of Korean children and adolescents.
Abstract The Committee on Dyslipidemia of Korean Pediatric and Adolescents of the Korean Society of Pediatric Endocrinology has newly developed evidence-based clinical practice guidelines for dyslipidemia in Korean children and adolescents. These guidelines were formulated with the Grading of Recommendations, which include both the strength of recommendations and the quality of evidence. In the absence of sufficient evidence, conclusions were based on expert opinion. These guidelines are based on the 2011 National Heart, Lung, and Blood Institute Guidelines, which focus on the prevention of cardiovascular disease ...
Source: Clinical Lung Cancer - December 1, 2020 Category: Cancer & Oncology Authors: Lim JS, Kim EY, Kim JH, Yoo JH, Yi KH, Chae HW, Choi JH, Kim JY, Hwang IT, Committee of Dyslipidemia of Korean Children and Adolescents on behalf of Korean Society of Pediatric Endocrinology (KSPE) Tags: Clin Exp Pediatr Source Type: research

Alpinetin delays HFD-aggravated lung carcinogenesis.
This study was carried out to elucidate the effect of ALP on high-fat diet (HFD)-induced aggressive cancer progression. C57BL/6 mice were fed with a control diet (CD) or HFD and administered with ALP. Following six weeks of feeding, mice were inoculated subcutaneously with Lewis lung carcinoma cells (LLC) to develop transplanted lung tumour. ALP suppressed cell proliferation which drives HFD-induced lung cancer progression. ALP inhibited lipid accumulation in tumour and tumour cells cultured in vitro. qPCR and ELISA analysis of tumour tissues revealed ALP restrained macrophages accumulation, M2s polarization and chemokine ...
Source: Clinical Lung Cancer - December 1, 2020 Category: Cancer & Oncology Authors: Hou S, Yuan Q, Cheng C, Zhang Z, Guo B, Yuan X Tags: Basic Clin Pharmacol Toxicol Source Type: research

Epidemiological and clinical course of 483 patients with COVID-19 in Wuhan, China: a single-center, retrospective study from the mobile cabin hospital.
Abstract During the COVID-19 outbreak, the mobile cabin hospital has effectively isolated and treated patients diagnosed as mild-moderate disease. However, a detailed clinical course has not been well described. We included 483 patients who were isolated and treated from Feb 6, 2020, to Feb 15, 2020, including definite outcome (discharge or deterioration). Sixty-two patients were transferred to severe cases, of whom were trasfered to designated hospital for intensive care. By March 9, 2020, all patients were discharged without dead. The mobile cabin hospital provides feasible strategy of isolation of mild-moderate...
Source: Clinical Lung Cancer - November 27, 2020 Category: Cancer & Oncology Authors: Wang B, Wang Z, Zhao J, Zeng X, Wu M, Wang S, Wang T Tags: Eur J Clin Microbiol Infect Dis Source Type: research

Pre-surgical assessment of mediastinal lymph node metastases in Stage IA non-small-cell lung cancers.
CONCLUSION: Based on these results, clinical Stage IA for non-small-cell-lung-cancers with nonsolid, part-solid, or solid consistency should be based on pre-surgical CT maximum tumor diameter and lymph node short-axis measurements on CT ≤20 mm. Further prospective evaluation of these clinical Stage IA staging criteria is needed. PMID: 32570011 [PubMed - indexed for MEDLINE] (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - November 26, 2020 Category: Cancer & Oncology Authors: Wang Y, Zhu Y, Yip R, Lee DS, Flores RM, Kaufman A, Henschke CI, Yankelevitz DF, I-ELCAP Investigators Tags: Clin Imaging Source Type: research

Imaging features of gastrointestinal toxicity in non-small cell lung cancer patients treated with erlotinib: A single institute 13-year experience.
CONCLUSION: Erlotinib-associated GT was identified in 15% patients with NSCLC. Fluid-filled colon and segmental involvement were the most common imaging manifestations. PMID: 32892106 [PubMed - indexed for MEDLINE] (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - November 26, 2020 Category: Cancer & Oncology Authors: Pfau D, Guler E, Smith DA, Matsunaga F, Kikano EG, Tirumani SH, Dowlati A, Ramaiya NH Tags: Clin Imaging Source Type: research

Genetic Biomarkers: Implications of Increased Understanding and Identification in Lung Cancer Management.
Abstract BACKGROUND: In the management of lung cancer, molecular profiling of the tumor is pivotal to defining a personalized treatment plan and is recommended for each patient. OBJECTIVES: The purpose of this article is to provide an update on genomic testing in lung cancer and the associated targeted treatment options. In addition, emerging biomarkers and mechanisms of resistance are discussed. METHODS: A comprehensive review of the CINAHL®, MEDLINE®, and PubMed® databases was performed. FINDINGS: Molecular tumor profiling has advanced treatment options for patients diagnosed with lung...
Source: Clinical Lung Cancer - November 21, 2020 Category: Cancer & Oncology Authors: Martin JC Tags: Clin J Oncol Nurs Source Type: research

Plasma levels of platinum-induced fatty acid [16:4n-3] do not affect response to platinum-based chemotherapy: A pilot study in non-small cell lung cancer patients.
CONCLUSIONS: This first of its kind study that evaluated plasma 16:4(n-3) in NSCLC patients showed that 16:4 (n-3) was elevated during FO supplementation, independent of fish oil supplementation or platinum-based chemotherapy. PMID: 33183547 [PubMed - in process] (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - November 17, 2020 Category: Cancer & Oncology Authors: van der Meij BS, Teleni L, Stanislaus AE, Murphy RA, Robinson L, Damaraju VL, Chu Q, Sawyer MB, Mazurak V Tags: Clin Nutr ESPEN Source Type: research

Comparison of the prognostic value of MUST, ECOG-PS, mGPS and CT derived body composition analysis in patients with advanced lung cancer.
Abstract BACKGROUND: Assessment of malnutrition, performance status and systemic inflammation are routine aspects of clinical assessment in patients with advanced cancer. There is increasing evidence that body composition measurements from routine staging CT also have prognostic value. To date the relative prognostic value of Malnutrition Universal Screening Tool (MUST), Eastern Cooperative Oncology Group Performance Status (ECOG-PS), modified Glasgow Prognostic score (mGPS) and CT derived body composition analysis in patients with advanced lung cancer has not been examined. The aim of the present study was to exa...
Source: Clinical Lung Cancer - November 17, 2020 Category: Cancer & Oncology Authors: Abbass T, Dolan RD, MacLeod N, Horgan PG, Laird BJ, McMillan DC Tags: Clin Nutr ESPEN Source Type: research

Phase I trial of nedaplatin and S-1 in patients with advanced squamous cell lung cancer.
Abstract The platinum doublet is considered to be the standard cytotoxic chemotherapy for advanced lung cancer. It has been previously reported that nedaplatin and S-1 have clinical efficacy against squamous cell lung cancer. As the combination of nedaplatin and S-1 has never been studied for advanced squamous cell lung cancer, a phase I trial of this combination in the first-line setting was conducted. Patients who had not received chemotherapy previously, aged ≤75 years and with advanced squamous cell lung cancer were recruited. Nedaplatin was administered intravenously (day 1), and S-1 was orally administere...
Source: Clinical Lung Cancer - November 17, 2020 Category: Cancer & Oncology Authors: Kanaji N, Ishii T, Ueda Y, Ichikawa H, Kishimoto N, Kadowaki N Tags: Mol Clin Oncol Source Type: research

Health Disparities in Environmental and Occupational Lung Disease.
This article focuses on disparities in disease prevalence, morbidity, and mortality for asthma, chronic obstructive pulmonary disease, pneumoconiosis, and lung cancer. Disparities are categorized by race, age, sex, socioeconomic status, and geographic region. Each category highlights differences in risk factors for the development and severity of lung disease. Risk factors include social, behavioral, economic, and biologic determinants of health (occupational/environmental exposures, psychosocial stressors, smoking, health literacy, health care provider bias, and health care access). Many of these risk factors are complex ...
Source: Clinical Lung Cancer - November 11, 2020 Category: Cancer & Oncology Authors: Brigham E, Allbright K, Harris D Tags: Clin Chest Med Source Type: research

Coal Workers' Pneumoconiosis and Other Mining-Related Lung Disease: New Manifestations of Illness in an Age-Old Occupation.
Abstract Coal workers' pneumoconiosis (CWP) and other mining-related lung diseases are entirely preventable, yet continue to occur. While greater attention has been given to CWP and silicosis, mining exposures cause a broad spectrum of respiratory disease, including chronic bronchitis, emphysema, and pulmonary fibrosis. Physicians must obtain a detailed occupational and exposure history from miners in order to make an accurate diagnosis and determine the risk of disease progression. Mining-related lung diseases are incurable and difficult to treat. Therefore, primary prevention by limiting dust exposure and second...
Source: Clinical Lung Cancer - November 11, 2020 Category: Cancer & Oncology Authors: Go LHT, Cohen RA Tags: Clin Chest Med Source Type: research

Silicosis: An Update and Guide for Clinicians.
Abstract This overview provides an update on silicosis epidemiology with review of exposures and emerging trends in acute and accelerated silicosis in the twenty-first century. The silicosis epidemics in mining, denim sandblasting, and engineering stone industries are highlighted. Clinical presentations of silicosis and silica-related conditions such as autoimmune, kidney, and mycobacterial disease, as well as lung cancer, are discussed. Important aspects of the new OSHA 2017 Silica Standard are presented. This review also includes practical guidance for clinicians to address questions that may arise when evaluati...
Source: Clinical Lung Cancer - November 11, 2020 Category: Cancer & Oncology Authors: Krefft S, Wolff J, Rose C Tags: Clin Chest Med Source Type: research

Screening for Occupational Lung Cancer: An Unprecedented Opportunity.
Abstract Selected occupational populations are at the highest risk of lung cancer, because they smoke at increased rates and are concurrently exposed to workplace lung carcinogens. Low-dose computed tomography (CT)-based lung cancer screening has an enormous potential to reduce lung cancer mortality in these populations, as shown both in the lung cancer screening studies in the general population and in studies of workers at high risk of lung cancer. Pulmonologists can play a key role in identifying workers at high risk of lung cancer and ensuring that they are offered annual low-dose CT scans for early lung cance...
Source: Clinical Lung Cancer - November 11, 2020 Category: Cancer & Oncology Authors: Markowitz SB, Dickens B Tags: Clin Chest Med Source Type: research

Lung cancer with nephrotic syndrome as a paraneoplastic syndrome: A case report.
Abstract Paraneoplastic syndromes are immune disorders associated with clinical signs and symptoms caused by substances produced by malignant diseases and are not directly associated with a primary or metastatic tumour. The symptoms are the effects of hormones, immune cross-reactivity or cytokines. Paraneoplastic nephrotic syndrome (PNS) is often associated with membranous nephropathy (MN) in elderly patients with solid tumours, and there is continued debate regarding whether corticosteroids or immunosuppressants should be combined with cancer therapy for the syndrome. The present report describes a male patient w...
Source: Clinical Lung Cancer - November 11, 2020 Category: Cancer & Oncology Authors: Yu X, Fan Z, Chen W, Wang Z Tags: Mol Clin Oncol Source Type: research

Cardiovascular and Pulmonary Challenges After Treatment of Childhood Cancer.
Abstract Childhood cancer survivors are at risk for developing cardiovascular disease and pulmonary disease related to cancer treatment. This might not become apparent until many years after treatment and varies from subclinical to life-threatening disease. Important causes are anthracyclines and radiotherapy involving heart, head, or neck for cardiovascular disease, and bleomycin, busulfan, nitrosoureas, radiation to the chest, and lung or chest surgery for pulmonary disease. Most effects are dose dependent, but genetic risk factors have been discovered. Treatment options are limited. Prevention and regular scree...
Source: Clinical Lung Cancer - November 4, 2020 Category: Cancer & Oncology Authors: Visscher H, Otth M, Feijen EAML, Nathan PC, Kuehni CE Tags: Pediatr Clin North Am Source Type: research

Potential relationship between the selenoproteome and cancer.
Abstract The role of the selenoproteome, which is the collection of all proteins containing selenium in an organism, in cancer development, growth and progression requires further investigation, due to the importance of selenium in both cancer and immune system function. Data about the selenoproteome, including its differential expression, single nucleotide variations, copy number variations, methylation, pathways and overall survival (OS) in five leading types of cancer are available from the GSCALite website. Subsequent to the analysis of these datasets, it was revealed that there was increased expression of GPX...
Source: Clinical Lung Cancer - November 4, 2020 Category: Cancer & Oncology Authors: Jia Y, Dai J, Zeng Z Tags: Mol Clin Oncol Source Type: research

Transformation from adenocarcinoma to squamous cell carcinoma associated with long-term administration of EGFR-TKIs.
Abstract Although patients with non-small cell lung cancer exhibiting EGFR mutations generally respond to tyrosine kinase inhibitors (TKIs), the majority of patients acquire resistance ~1 year after treatment. EGFR T790M mutations, MET or HER2 amplifications and phenotypic transformations contribute to the mechanism of EGFR-TKI resistance. The transformation of small cell lung cancer frequently occurs, although few convert to squamous cell carcinoma associated with the administration of EGFR-TKIs. The current study reports a case of EGFR-mutated adenocarcinoma of the lung that transitioned to squamous cell carcino...
Source: Clinical Lung Cancer - October 25, 2020 Category: Cancer & Oncology Authors: Haruki T, Nakanishi A, Matsui S, Kidokoro Y, Kubouchi Y, Takagi Y, Taniguchi Y, Nakamura H Tags: Mol Clin Oncol Source Type: research

CONCORDE: A phase I platform study of novel agents in combination with conventional radiotherapy in non-small-cell lung cancer.
ng RJ, Faivre-Finn C, Greystoke A Abstract Lung cancer is the leading cause of cancer mortality worldwide and most patients are unsuitable for 'gold standard' treatment, which is concurrent chemoradiotherapy. CONCORDE is a platform study seeking to establish the toxicity profiles of multiple novel radiosensitisers targeting DNA repair proteins in patients treated with sequential chemoradiotherapy. Time-to-event continual reassessment will facilitate efficient dose-finding. PMID: 33072895 [PubMed] (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - October 21, 2020 Category: Cancer & Oncology Authors: Walls GM, Oughton JB, Chalmers AJ, Brown S, Collinson F, Forster MD, Franks KN, Gilbert A, Hanna GG, Hannaway N, Harrow S, Haswell T, Hiley CT, Hinsley S, Krebs M, Murden G, Phillip R, Ryan AJ, Salem A, Sebag-Montefoire D, Shaw P, Twelves CJ, Walker K, Yo Tags: Clin Transl Radiat Oncol Source Type: research

Invasion of poorly differentiated large-cell neuroendocrine tumor of the lung through right pulmonary veins into the left atrium: A very rare case report.
Abstract Intracavitary cardiac metastasis is a rare manifestation of primary lung cancer which can be associated with a very poor prognosis. In this condition, the right chambers of the heart are more commonly involved and the invasion of the left atrium (LA) through the venous routes is highly exceptional. Poorly differentiated large-cell neuroendocrine tumors also include only 3% of all primary lung carcinomas which can have adverse outcomes. Therefore, in this report, a rare case of a 72-year-old male patient with poorly differentiated large-cell neuroendocrine carcinoma of the right lung spreading to the LA th...
Source: Clinical Lung Cancer - October 9, 2020 Category: Cancer & Oncology Authors: Nosrati A, Nabati M, Vahedi L, Shokri M Tags: J Clin Ultrasound Source Type: research

Efficacy of immune checkpoint inhibitor monotherapy for patients with massive non-small-cell lung cancer.
CONCLUSION: The presence of massive lesions (max diameters > 50 mm) is an independent prognostic factor in advanced NSCLC treated with ICI monotherapy. Although overall response rates were similar between groups A and B, the disease control rate was significantly poorer for group A. Max BTS might be useful for predicting clinical outcomes for patients undergoing immunotherapy as a parameter reflecting their tumor burden. PMID: 32462297 [PubMed - indexed for MEDLINE] (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - October 8, 2020 Category: Cancer & Oncology Authors: Hakozaki T, Hosomi Y, Kitadai R, Kitagawa S, Okuma Y Tags: J Cancer Res Clin Oncol Source Type: research

Overall survival benefit of continuing immune checkpoint inhibitors treatment post dissociated response in patients with advanced lung cancer.
Abstract PURPOSE: Dissociated response (DR, reduction at baseline or increase 
Source: Clinical Lung Cancer - October 8, 2020 Category: Cancer & Oncology Authors: Zhou H, Sun Y, Xiu W, Han J, Zhong L, Suo J, Wei H, Wang Y, Zhu J Tags: J Cancer Res Clin Oncol Source Type: research

Clinical outcomes of nivolumab in patients with advanced non-small cell lung cancer in real-world practice, with an emphasis on hyper-progressive disease.
CONCLUSION: Although the efficacy of nivolumab in real-world patients was comparable to that seen in clinical trials, clinicians should be aware of HPD because it is not uncommon and represents a worse prognosis. PMID: 32583235 [PubMed - indexed for MEDLINE] (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - October 8, 2020 Category: Cancer & Oncology Authors: Kim SH, Choi CM, Lee DH, Kim SW, Yoon S, Kim WS, Ji W, Lee JC Tags: J Cancer Res Clin Oncol Source Type: research

Identification of prognostic biomarkers for major subtypes of non-small-cell lung cancer using genomic and clinical data.
CONCLUSION: This study advocates that investigating the survival-specific biomarkers restricted to respective cohorts can advance subtype-specific prognosis, diagnosis, and treatment for NSCLC patients. Prognostic models and markers described for each subtype may provide insight into the heterogeneity of disease etiology and help in the development of new therapeutic approaches for the treatment of NSCLC patients. PMID: 32661603 [PubMed - indexed for MEDLINE] (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - October 8, 2020 Category: Cancer & Oncology Authors: Lathwal A, Kumar R, Arora C, Raghava GPS Tags: J Cancer Res Clin Oncol Source Type: research

Prognostic value of TP53 co-mutation status combined with EGFR mutation in patients with lung adenocarcinoma.
CONCLUSIONS: TP53 MUT is a poor prognostic factor in LUAD patients, and the prognosis of TP53/EGFR co-mutation is worse. GPC3, CCL28, GPR37, and NPY may be novel prognostic markers and potential therapeutic targets for patients with dual TP53/EGFR mutation LUAD. PMID: 32743759 [PubMed - indexed for MEDLINE] (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - October 8, 2020 Category: Cancer & Oncology Authors: Wang F, Zhao N, Gao G, Deng HB, Wang ZH, Deng LL, Yang Y, Lu C Tags: J Cancer Res Clin Oncol Source Type: research

Efficacy and safety of TCM combined with chemotherapy for SCLC: a systematic review and meta-analysis.
Abstract BACKGROUND: Chemotherapy is the standard treatment for small cell lung cancer (SCLC), but chemotherapy resistance and adverse reactions remain major problems. Although Traditional Chinese Medicine (TCM) is wildly applied for patients with SCLC in China, the evidence of TCM in the treatment for SCLC is limited. PURPOSE: To evaluate the efficacy and safety of TCM combined with chemotherapy for patients with SCLC. METHOD: We conducted a systematic search of PubMed, EMBASE, the Chinese National Knowledge Infrastructure, the VIP Information Database, and the Wanfang Database for randomized-controlled...
Source: Clinical Lung Cancer - October 8, 2020 Category: Cancer & Oncology Authors: Chen S, Bao Y, Xu J, Zhang X, He S, Zhang Z, Qi R, Jiang J, Liu R, Guo Q, Zhang X, Xi Y, Zheng H, Hua B Tags: J Cancer Res Clin Oncol Source Type: research

The P2X7 purinergic receptor: a potential therapeutic target for lung cancer.
CONCLUSION: In summary, P2X7R is expected to become a potential target for the treatment of lung cancer, and more clinical research is needed in the future to explore the effectiveness of P2X7R antagonists as treatments. PMID: 32892231 [PubMed - indexed for MEDLINE] (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - October 8, 2020 Category: Cancer & Oncology Authors: Li Q, Zhu X, Song W, Peng X, Zhao R Tags: J Cancer Res Clin Oncol Source Type: research

The Staging of Malignant Pleural Mesothelioma.
Abstract Staging of malignant pleural mesothelioma has been challenging because of a paucity of cases and poor survival. At least 5 staging systems were proposed before 1990 until the first consensus system was published in 1995. This system used tumor, node, metastasis designations and borrowed heavily from parenchymal lung cancer descriptors. With the establishment of a database to collect cases from 1995 to 2013, evidence-based revisions to the 1995 staging classification were published in 2016. With improving imaging technology, clinical staging will become more refined and, it is hoped, more useful for progno...
Source: Clinical Lung Cancer - October 6, 2020 Category: Cancer & Oncology Authors: Euhus CJ, Ripley RT Tags: Thorac Surg Clin Source Type: research

The Role of Extrapleural Pneumonectomy in Malignant Pleural Mesothelioma.
Abstract Extrapleural pneumonectomy (EPP) is the most extensive form of surgery for mesothelioma, involving en bloc resection of visceral and parietal pleura, lung, diaphragm and pericardium, with reconstruction of the pericardium and diaphragm. It can be performed safely in carefully selected patients. It should be performed in experienced centers as part of a multimodality treatment plan. The SMART approach, with a short course of induction hemithoracic radiation followed by EPP has demonstrated safety and value of hypofractionated hemithoracic radiation combined with complete macroscopic resection. We are condu...
Source: Clinical Lung Cancer - October 6, 2020 Category: Cancer & Oncology Authors: Donahoe LL, de Perrot M Tags: Thorac Surg Clin Source Type: research

Taken Together: Effective Multimodal Approaches for Malignant Pleural Mesothelioma.
Abstract Malignant pleural mesothelioma is an aggressive, deadly cancer often requiring input from multiple medical disciplines. Treatment has evolved over the last several decades with increasing evidence and ongoing advances in chemotherapy, radiation, and immunotherapy; however, no standard treatment regimen has yet been defined. Regardless of the overall strategy, surgery remains the foundation of treatment to remove macroscopic disease, and preservation of lung parenchyma via extended pleurectomy/decortication may be preferable to extrapleural pneumonectomy. PMID: 33012435 [PubMed - in process] (Source: ...
Source: Clinical Lung Cancer - October 6, 2020 Category: Cancer & Oncology Authors: Song KJ, Flores RM, Wolf AS Tags: Thorac Surg Clin Source Type: research

Smoking-Related Social Interactions as Experienced by Persons Who Smoked Long-term.
CONCLUSIONS: Clinical nurse specialists should promote antismoking campaigns that are not stigmatizing, discuss health risks of smoking in a respectful manner, provide evidence-based cessation resources, improve communication with persons who smoke, and address stigma in programs to improve screening for smoking-related illnesses. PMID: 33009116 [PubMed - as supplied by publisher] (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - October 5, 2020 Category: Cancer & Oncology Authors: Draucker CB, Rawl SM, Vode E, Fields M, Elkins C, Morgan O, Perez SR, Straber L, Carter-Harris L Tags: Clin Nurse Spec Source Type: research

Prophylactic cranial irradiation for extensive-stage small cell lung cancer: Analysis based on active brain MRI surveillance.
This study was conducted to evaluate the role of PCI for ES-SCLC under active brain magnetic resonance imaging (MRI) surveillance. Materials and methods: Patients with ES-SCLC who showed any responses after first-line chemotherapy and no initial brain metastasis (BM) were retrospectively included. Active brain MRI surveillance was performed for all patients. Progression-free survival (PFS) and overall survival (OS) were compared between PCI and non-PCI patients. The time-related hazard of BM was evaluated in non-PCI patients. Results: One hundred and eighteen consecutive patients were included in the study. The m...
Source: Clinical Lung Cancer - October 2, 2020 Category: Cancer & Oncology Authors: Yu J, Ouyang W, Yang Y, Zhang X, Zhou Y, Zhang J, Xie C Tags: Clin Transl Radiat Oncol Source Type: research

Imaging spectrum of NUT carcinomas.
Abstract Nuclear protein of the testis (NUT) carcinoma (NC) (formerly known as NUT midline carcinoma) is an aggressive pleomorphic squamous cell carcinoma with a dismal prognosis. Primary NC tumors are commonly located in the chest or head and neck regions. Imaging plays an indispensable role in the staging, management, treatment response assessment, and surveillance of NC. Primary pulmonary NC usually presents as a large mass with lymphadenopathy and pleural involvement. Primary head and neck NC presents as a large expansile necrotic mass in the sinonasal region with locoregional destruction and occasional cervic...
Source: Clinical Lung Cancer - September 26, 2020 Category: Cancer & Oncology Authors: Virarkar M, Saleh M, Ramani NS, Morani AC, Bhosale P Tags: Clin Imaging Source Type: research

Chest-CT findings of COVID-19 in patients with pre-existing malignancies; a pictorial review.
Abstract As of April 17th, 2020, more than 2,190,010 COVID-19 cases with 147,010 deaths have been recorded worldwide. It has been suggested that a high mortality rate occurs in patients with severe disease and is associated with advanced age and underlying comorbidities, such as malignancies. To the best of our knowledge, no study has been conducted to evaluate chest CT features in patients with malignancy and concomitant COVID-19 infection. In fact, the imaging findings can be challenging and have not yet been fully understood in this setting. In this manuscript, we go over imaging findings in chest CT of patient...
Source: Clinical Lung Cancer - September 22, 2020 Category: Cancer & Oncology Authors: Katal S, Aghaghazvini L, Gholamrezanezhad A Tags: Clin Imaging Source Type: research

An extragonadal germ cell tumor with dermatomyositis: A case report and literature review.
Abstract The risk of malignancy in inflammatory myopathy patients is well recognized. However, the incidence of germ cell tumor (GCT) with inflammatory myopathy is low, and most reported cases of GCT also exhibit testicular tumors. Therefore, a case of extragonadal GCT with dermatomyositis (DM) is reported in the current study to better understand this paraneoplastic syndrome. A 53-year-old man presented with bilateral cervical lymph node enlargement. A lymph node biopsy showed embryonal carcinoma, and computed tomography showed multiple lymph node and lung metastases. A period of one month after bleomycin, etopos...
Source: Clinical Lung Cancer - September 22, 2020 Category: Cancer & Oncology Authors: Fujiwara Y, Fukuda N, Ohmoto A, Nakano K, Ono M, Taira S, Torii J, Takamatsu M, Takahashi S Tags: Mol Clin Oncol Source Type: research

Metachronous bilateral breast metastases of a lung neuroendocrine tumor: A case report.
Abstract Breast metastases of primary lung neuroendocrine tumors are rarely reported. The current report presents the case of a 41-year old female with no history of smoking who initially underwent surgery for a breast fibroadenoma, during which a neuroendocrine tumor of the right lung was detected via chest X-ray. The patient underwent surgery for the tumor and developed right breast nodules after adjuvant chemotherapy. Histological and immunohistochemical examinations of biopsies from these nodules indicated breast metastasis of the primary lung neuroendocrine tumor. The patient underwent mastectomy of the right...
Source: Clinical Lung Cancer - September 4, 2020 Category: Cancer & Oncology Authors: Kotake M, Imai H, Onozato R, Fujita A, Fujisawa T, Nakazato Y, Iijima M, Yanagita Y, Hisada T, Minato K Tags: Mol Clin Oncol Source Type: research

Circular RNAs: Promising Molecular Biomarkers of Human Aging-Related Diseases via Functioning as an miRNA Sponge.
Abstract Circular RNAs (circRNAs) are a new class of noncoding single-stranded RNAs that differ from linear microRNAs (miRNAs), since they form covalently closed loop structures without free 3' poly(A) tails or 5' caps. circRNAs are the competitive endogenous RNAs (ceRNAs) by binding to miRNA through miRNA response elements (MREs) (i.e., "miRNA sponge"), thereby reducing the quantity of miRNA available to target mRNA, subsequently promoting mRNA stability or protein expression, which involves the initiation and progress of human diseases. Owing to these features of abundance, stability, conservative prop...
Source: Clinical Lung Cancer - July 10, 2020 Category: Cancer & Oncology Authors: Ren S, Lin P, Wang J, Yu H, Lv T, Sun L, Du G Tags: Mol Ther Methods Clin Dev Source Type: research

Added value of invasive needle techniques in mediastinal and hilar nodal staging of clinical N0-N1 non-small cell lung cancer after positron emission tomography.
Abstract Previous studies evaluating staging methods of lung cancer have focused on mediastinal disease. We explored the added value of endoscopic techniques after PET scan in the evaluation of N1 nodal stations in 276 patients with a radiologically normal mediastinum demonstrating a potential stage shift in 20% of patients. PMID: 32613092 [PubMed] (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - July 4, 2020 Category: Cancer & Oncology Authors: Collin-Castonguay MM, Guinde J, Laflamme L, Marcoux S, Fortin M Tags: Clin Transl Radiat Oncol Source Type: research

Interventional Pulmonology: A Brave New World.
Abstract Interventional pulmonology is a dynamic and evolving field in respiratory medicine. Advances have improved the ability to diagnose and manage diseases of the airways. A shift toward early detection of malignant disease has generated a focus on innovative diagnostic techniques. With patient populations living longer with malignant and benign diseases, the role for interventional bronchoscopy has grown. In cancer groups, novel immunotherapies have improved the prospects of clinical outcomes and reignited a focus on optimizing patient performance status to enable access to anticancer therapy. This review dis...
Source: Clinical Lung Cancer - July 1, 2020 Category: Cancer & Oncology Authors: Kalsi HS, Thakrar R, Gosling AF, Shaefi S, Navani N Tags: Thorac Surg Clin Source Type: research