Availability of genome-matched therapy based on clinical practice
CONCLUSION: This study demonstrated the usefulness of CGP for patients with sarcoma and HNC in addition to lung cancer in clinical practice. Performing CGP at the front line has the potential to improve the availability of genome-matched therapy.PMID:38668785 | DOI:10.1007/s10147-024-02533-z (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 26, 2024 Category: Cancer & Oncology Authors: Naomi Hayashi Seiichi Mori Akihiro Ohmoto Ippei Fukada Masumi Yamazaki Mari Hosonaga Xiaofei Wang Arisa Ueki Kazuma Kiyotani Akiko Tonooka Kengo Takeuchi Shunji Takahashi Source Type: research
Prognostic importance of prognostic nutritional index and modified Glasgow prognostic score in advanced lung cancer with targetable mutation
CONCLUSION: Both PNI and mGPS can be used as a reliable, inexpensive, and easily applicable prognostic index in the advanced lung cancer patients who had the targetable mutation and also received targeted therapy.PMID:38668879 | DOI:10.1007/s00432-023-05529-w (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 26, 2024 Category: Cancer & Oncology Authors: Burak Bilgin Yunus Kuralay Sebnem Yucel Source Type: research
Efficacy and safety of chemoimmunotherapy in advanced non-small cell lung cancer patients with antibiotics-induced dysbiosis: a propensity-matched real-world analysis
CONCLUSION: Antibiotic-induced dysbiosis may not affect the efficacy of chemo-IOs in patients with advanced NSCLC.PMID:38668936 | DOI:10.1007/s00432-024-05649-x (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 26, 2024 Category: Cancer & Oncology Authors: Kentaro Tamura Yusuke Okuma Shogo Nomura Akito Fukuda Ken Masuda Yuji Matsumoto Yuki Shinno Tatsuya Yoshida Yasushi Goto Hidehito Horinouchi Noboru Yamamoto Yuichiro Ohe Source Type: research
Cell-Derived Allograft Models as a Solution to the Obstacles of Preclinical Studies under Limited Resources: A Systematic Review on Experimental Lung Cancer Animal Models
CONCLUSION: Based on the results, the use of cell-derived allograft models in cancer studies is feasible and relevant, and it provides valuable insights regarding the conditions with limited resources.PMID:38659262 | DOI:10.2174/0127724328295592240419064719 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 25, 2024 Category: Cancer & Oncology Authors: Isa Mahendra Ahmad Kurniawan Muhamad Basit Febrian Iim Halimah Asep Rizaludin Dani Gustaman Syarif Source Type: research
Comprehensive genomic profiling of pulmonary spindle cell carcinoma using tissue and plasma samples: insights from a real-world cohort analysis
We present comprehensive genomic profiling results of baseline tumor samples from 22 patients histologically diagnosed with PSCC, representing the largest cohort to date. Somatic genetic variant detection was compared between paired plasma samples and primary tumors from 13 patients within our cohort. The associations among genomic features, treatment, and prognosis were also analyzed in representative patient cases. TP53 (54.5%), TERT (36.4%), CDKN2A (27.3%), and MET (22.7%) were most frequently mutated. Notably, 81.8% of patients had actionable targets in their baseline tumors, including MET (22.7%), ERBB2 (13.6%), EGFR ...
Source: Clinical Lung Cancer - April 25, 2024 Category: Cancer & Oncology Authors: Yi Sun Shilei Qin Song Wang Jiaohui Pang Qiuxiang Ou Weiquan Liang Hai Zhong Source Type: research
Impact of abdominal compression on heart and stomach motion for stereotactic arrhythmia radioablation
CONCLUSIONS: AC was not a consistent motion management method for STAR, nor does not uniformly affect the separation distance between LVCs and the stomach. If AC is employed in future STAR protocols, the motion of the target volume and its relative distance to the stomach should be compared on two 4DCTs: one while the patient is FB and one under AC.PMID:38661250 | DOI:10.1002/acm2.14346 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 25, 2024 Category: Cancer & Oncology Authors: Daniel David Cecchi Nicolas Paul Ploquin Salman Faruqi Hali Morrison Source Type: research
High core 1beta1,3-galactosyltransferase 1 expression is associated with poor prognosis and promotes cellular radioresistance in lung adenocarcinoma
CONCLUSION: Elevated C1GALT1 expression in LUAD is associated with an unfavorable prognosis and contributes to increased radioresistance potentially by affecting DNA repair, cell proliferation, cell cycle regulation, and epithelial-mesenchymal transition (EMT).PMID:38662050 | DOI:10.1007/s00432-024-05745-y (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 25, 2024 Category: Cancer & Oncology Authors: Yong Chen Yanyan Ji Lin Shen Ying Li Yue Ren Hongcan Shi Yue Li Yunjiang Wu Source Type: research
Extrachromosomal circular DNA (eccDNA): from carcinogenesis to drug resistance
Clin Exp Med. 2024 Apr 25;24(1):83. doi: 10.1007/s10238-024-01348-6.ABSTRACTExtrachromosomal circular DNA (eccDNA) is a circular form of DNA that exists outside of the chromosome. Although it has only been a few decades since its discovery, in recent years, it has been found to have a close relationship with cancer, which has attracted widespread attention from researchers. Thus far, under the persistent research of researchers from all over the world, eccDNA has been found to play an important role in a variety of tumors, including breast cancer, lung cancer, ovarian cancer, etc. Herein, we review the sources of eccDNA, c...
Source: Clinical Lung Cancer - April 25, 2024 Category: Cancer & Oncology Authors: Zhaoxing Li Daohai Qian Source Type: research
Peripheral NK cells identified as the predictor of response in extensive-stage small cell lung cancer patients treated with first-line immunotherapy plus chemotherapy
CONCLUSION: In patients with ES-SCLC, the percentage and changes in peripheral NK cells can predict the response to combined immunotherapy and chemotherapy.PMID:38662170 | DOI:10.1007/s12094-024-03479-4 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 25, 2024 Category: Cancer & Oncology Authors: Yanan Cui Yanping Chen Peiyan Zhao Shuang Li Ying Cheng Xiubao Ren Source Type: research
Chromosomal 3q amplicon encodes essential regulators of secretory vesicles that drive secretory addiction in cancer
J Clin Invest. 2024 Apr 25:e176355. doi: 10.1172/JCI176355. Online ahead of print.ABSTRACTCancer cells exhibit heightened secretory states that drive tumor progression. Here, we identify a chromosome 3q amplicon that serves as a platform for secretory regulation in cancer. The 3q amplicon encodes multiple Golgi-resident proteins, including the scaffold Golgi integral membrane protein 4 (GOLIM4) and the ion channel ATPase Secretory Pathway Ca2+ Transporting 1 (ATP2C1). We show that GOLIM4 recruits ATP2C1 and Golgi phosphoprotein 3 (GOLPH3) to coordinate calcium-dependent cargo loading and Golgi membrane bending and vesicle ...
Source: Clinical Lung Cancer - April 25, 2024 Category: Cancer & Oncology Authors: Xiaochao Tan Shike Wang Guan-Yu Xiao Chao Wu Xin Liu Biyao Zhou Jiang Yu Dzifa Yawa Duose Yuanxin Xi Jing Wang Kunika Gupta Apar Pataer Jack A Roth Michael P Kim Fengju Chen Chad J Creighton William K Russell Jonathan M Kurie Source Type: research
Tumour organoids and assembloids: Patient-derived cancer avatars for immunotherapy
CONCLUSION: Fundamental research and clinical trials are ongoing, and the intention is to use these models to replace animals. Pre-clinical immunotherapy screening using PDTOs will be beneficial to cancer patients.KEY POINTS: The current PDTO models have not yet constructed key cellular and non-cellular components. PDTOs should be expandable and editable. PDTOs are promising preclinical models for immunotherapy unless mature PDTOs can be established. PDTO biobanks with consensual standards are urgently needed.PMID:38664597 | DOI:10.1002/ctm2.1656 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 25, 2024 Category: Cancer & Oncology Authors: Jie Mei Xingjian Liu Hui-Xiang Tian Yixuan Chen Yang Cao Jun Zeng Yung-Chiang Liu Yaping Chen Yang Gao Ji-Ye Yin Peng-Yuan Wang Source Type: research
Correction: Improvements in lung function following vitamin C supplementation to pregnant smokers are associated with buccal DNA methylation at 5 years of age
Clin Epigenetics. 2024 Apr 25;16(1):59. doi: 10.1186/s13148-024-01664-4.NO ABSTRACTPMID:38664854 | DOI:10.1186/s13148-024-01664-4 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 25, 2024 Category: Cancer & Oncology Authors: Lyndsey E Shorey-Kendrick Cindy T McEvoy Kristin Milner Julia Harris Julie Brownsberger Robert S Tepper Byung Park Lina Gao Annette Vu Cynthia D Morris Eliot R Spindel Source Type: research
Cell-Derived Allograft Models as a Solution to the Obstacles of Preclinical Studies under Limited Resources: A Systematic Review on Experimental Lung Cancer Animal Models
CONCLUSION: Based on the results, the use of cell-derived allograft models in cancer studies is feasible and relevant, and it provides valuable insights regarding the conditions with limited resources.PMID:38659262 | DOI:10.2174/0127724328295592240419064719 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 25, 2024 Category: Cancer & Oncology Authors: Isa Mahendra Ahmad Kurniawan Muhamad Basit Febrian Iim Halimah Asep Rizaludin Dani Gustaman Syarif Source Type: research
NECTIN4 Amplification Is Frequent in Solid Tumors and Predicts Enfortumab Vedotin Response in Metastatic Urothelial Cancer
CONCLUSION: NECTIN4 amplifications are genomic predictors of EV responses and long-term survival in patients with mUC.PMID:38657187 | DOI:10.1200/JCO.23.01983 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Niklas Kl ümper Ngoc Khanh Tran Stefanie Zsch äbitz Oliver Hahn Thomas B üttner Florian Roghmann Christian Bolenz Friedemann Zengerling Constantin Schwab Dora Nagy Marieta Toma Glen Kristiansen Hendrik Heers Philipp Ivanyi G ünter Niegisch Camilla Mar Source Type: research
Added value of spectral computed tomography quantitative parameters for differentiating tuberculosis-associated fibrosing mediastinitis from endobronchial lung cancer: initial results
CONCLUSION: There was a moderate correlation between spectrum parameters and conventional parameters. Integrating conventional CT features with spectrum parameters could further improve the ability in differentiating TB-associated FM from EBLC.PMID:38658213 | DOI:10.1016/j.crad.2024.02.010 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 24, 2024 Category: Cancer & Oncology Authors: J Yang L Deng M Jing M Xu X Liu S Li L Zhang H Xi L Yuan J Zhou Source Type: research
