Lung Cancer Screening: An Opportunity to Promote Physical Activity?
JTO Clin Res Rep. 2024 Feb 20;5(3):100651. doi: 10.1016/j.jtocrr.2024.100651. eCollection 2024 Mar.NO ABSTRACTPMID:38496375 | PMC:PMC10940996 | DOI:10.1016/j.jtocrr.2024.100651 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - March 18, 2024 Category: Cancer & Oncology Authors: Alice Avancini Lorenzo Belluomini Morten Quist Sara Pilotto Source Type: research
The Impact of Immunotherapy Use in Stage IIIA (T1-2N2) NSCLC: A Nationwide Analysis
CONCLUSIONS: Increased use of IO was associated with a change in treatment patterns and improved survival for patients with stage IIIA(N2) NSCLC.PMID:38496376 | PMC:PMC10941003 | DOI:10.1016/j.jtocrr.2024.100654 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - March 18, 2024 Category: Cancer & Oncology Authors: Lye-Yeng Wong Douglas Z Liou Mohana Roy Irmina A Elliott Leah M Backhus Natalie S Lui Joseph B Shrager Mark F Berry Source Type: research
Biomarker Testing, Targeted Therapy and Clinical Trial Participation by Race Among Patients With Lung Cancer: A Real-World Medicaid Database Study
CONCLUSIONS: Patients with metastatic lung cancer with Medicaid coverage were found to have exceedingly low biomarker testing rates; only 57% had evidence of any biomarker testing. Although no consistent differences between Black and White races were identified, this study calls attention to care experienced by socioeconomically disadvantaged patients with metastatic lung cancer in the United States.PMID:38496377 | PMC:PMC10941001 | DOI:10.1016/j.jtocrr.2024.100643 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - March 18, 2024 Category: Cancer & Oncology Authors: Debora S Bruno Xiaohong Li Lisa M Hess Source Type: research
SOX-1 antibodies positive Lambert-Eaton myasthenic syndrome with occult small cell lung cancer: A case report
Clin Respir J. 2024 Mar;18(3):e13740. doi: 10.1111/crj.13740.ABSTRACTLambert-Eaton myasthenic syndrome (LEMS) is a rare paraneoplastic neurological syndrome of the neuromuscular transmission. The symptoms often progress slowly and can be misdiagnosed in early stage. Seropositive SOX-1 antibodies are support for the diagnosis of LEMS and have high specificity for small cell lung cancer (SCLC). In this paper, we report a case of a 56-year-old man with smoking history who was admitted to hospital with progressive muscle weakness of the proximal legs. LEMS was diagnosed by repetitive nerve stimulation (RNS) testing and seropos...
Source: Clinical Lung Cancer - March 18, 2024 Category: Cancer & Oncology Authors: Liming Zhao Hongyan He Weixin Han Yizhe Meng Lifei Kang Yanqiang Chen Source Type: research
Blood-based biomarkers in patients with non-small cell lung cancer treated with immune checkpoint blockade
J Exp Clin Cancer Res. 2024 Mar 16;43(1):82. doi: 10.1186/s13046-024-02969-1.ABSTRACTThe paradigm of non-small cell lung cancer (NSCLC) treatment has been profoundly influenced by the development of immune checkpoint inhibitors (ICI), but the range of clinical responses observed among patients poses significant challenges. To date, analyses of tumor biopsies are the only parameter used to guide prognosis to ICI therapy. Tumor biopsies, however, are often difficult to obtain and tissue-based biomarkers are limited by intratumoral heterogeneity and temporal variability. In response, there has been a growing emphasis on the d...
Source: Clinical Lung Cancer - March 17, 2024 Category: Cancer & Oncology Authors: Yo-Ting Tsai Jeffrey Schlom Renee N Donahue Source Type: research
Gli1-mediated tumor cell-derived bFGF promotes tumor angiogenesis and pericyte coverage in non-small cell lung cancer
CONCLUSION: The Gli1-bFGF axis is crucial for the crosstalk between lung cancer cells and vascular cells. Targeting Gli1 is a potential therapeutic approach for NSCLC angiogenesis.PMID:38493151 | PMC:PMC10944600 | DOI:10.1186/s13046-024-03003-0 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - March 17, 2024 Category: Cancer & Oncology Authors: Xueping Lei Zhan Li Manting Huang Lijuan Huang Yong Huang Sha Lv Weisong Zhang Zhuowen Chen Yuanyu Ke Songpei Li Jingfei Chen Xiangyu Yang Qiudi Deng Junshan Liu Xiyong Yu Source Type: research
Paraneoplastic/autoimmune myelopathies
Handb Clin Neurol. 2024;200:193-201. doi: 10.1016/B978-0-12-823912-4.00017-7.ABSTRACTParaneoplastic myelopathies are a rare but important category of myelopathy. They usually present with an insidious or subacute progressive neurologic syndrome. Risk factors include tobacco use and family history of cancer. Cerebrospinal fluid analysis usually shows lymphocytic pleocytosis with elevated protein. MRI findings suggest that paraneoplastic myelopathies include longitudinally extensive T2 hyperintensities that are tract-specific and accompanied by enhancement, but spinal MRIs can also be normal. The most commonly associated neu...
Source: Clinical Lung Cancer - March 17, 2024 Category: Cancer & Oncology Authors: Mayra Montalvo Eoin P Flanagan Source Type: research
Paraneoplastic antibodies targeting intracellular antigens
Handb Clin Neurol. 2024;200:335-346. doi: 10.1016/B978-0-12-823912-4.00021-9.ABSTRACTAlthough they are relatively rare, the diagnosis of paraneoplastic neurologic syndromes (PNS) can be aided by the identification of neural autoantibodies in patients' serum and cerebrospinal fluid (CSF). They often clinically manifest as characteristic syndromes, including limbic encephalitis, opsoclonus-myoclonus syndrome, paraneoplastic cerebellar degeneration, and paraneoplastic encephalomyelitis. The antibodies are directed either toward intracellular targets, or epitopes on the cell surface. As compared to cell surface antibodies, int...
Source: Clinical Lung Cancer - March 17, 2024 Category: Cancer & Oncology Authors: Jenny J Linnoila Source Type: research
Paraneoplastic neurologic manifestations of neuroendocrine tumors
Handb Clin Neurol. 2024;200:397-407. doi: 10.1016/B978-0-12-823912-4.00023-2.ABSTRACTNeuroendocrine neoplasms (NENs) are a heterogeneous group of tumors arising from the transformation of neuroendocrine cells in several organs, most notably the gastro-entero-pancreatic system and respiratory tract. The classification was recently revised in the 5th Edition of the WHO Classification of Endocrine and Neuroendocrine Tumors. NENs can rarely spread to the central or peripheral nervous systems. Neurologic involvement is determined by the rare development of paraneoplastic syndromes, which are remote effects of cancer. Mechanisms...
Source: Clinical Lung Cancer - March 17, 2024 Category: Cancer & Oncology Authors: Marco Zoccarato Wolfgang Grisold Source Type: research
Blood-based biomarkers in patients with non-small cell lung cancer treated with immune checkpoint blockade
J Exp Clin Cancer Res. 2024 Mar 16;43(1):82. doi: 10.1186/s13046-024-02969-1.ABSTRACTThe paradigm of non-small cell lung cancer (NSCLC) treatment has been profoundly influenced by the development of immune checkpoint inhibitors (ICI), but the range of clinical responses observed among patients poses significant challenges. To date, analyses of tumor biopsies are the only parameter used to guide prognosis to ICI therapy. Tumor biopsies, however, are often difficult to obtain and tissue-based biomarkers are limited by intratumoral heterogeneity and temporal variability. In response, there has been a growing emphasis on the d...
Source: Clinical Lung Cancer - March 17, 2024 Category: Cancer & Oncology Authors: Yo-Ting Tsai Jeffrey Schlom Renee N Donahue Source Type: research
Gli1-mediated tumor cell-derived bFGF promotes tumor angiogenesis and pericyte coverage in non-small cell lung cancer
CONCLUSION: The Gli1-bFGF axis is crucial for the crosstalk between lung cancer cells and vascular cells. Targeting Gli1 is a potential therapeutic approach for NSCLC angiogenesis.PMID:38493151 | DOI:10.1186/s13046-024-03003-0 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - March 17, 2024 Category: Cancer & Oncology Authors: Xueping Lei Zhan Li Manting Huang Lijuan Huang Yong Huang Sha Lv Weisong Zhang Zhuowen Chen Yuanyu Ke Songpei Li Jingfei Chen Xiangyu Yang Qiudi Deng Junshan Liu Xiyong Yu Source Type: research
Association between thyroid disorders and extra-thyroidal cancers, a review
Clin Transl Oncol. 2024 Mar 15. doi: 10.1007/s12094-024-03434-3. Online ahead of print.ABSTRACTThyroid hormone has been shown to have both tumor-promoting and tumor-suppressing actions, which has led to significant debate over its involvement in the development of cancer. Proliferation, apoptosis, invasiveness, and angiogenesis are all aspects of cancer that are affected by the thyroid hormones T3 and T4, according to research conducted in animal models and in vitro experiments. The effects of thyroid hormones on cancer cells are mediated by many non-genomic mechanisms, one of which involves the activation of the plasma me...
Source: Clinical Lung Cancer - March 16, 2024 Category: Cancer & Oncology Authors: Xin Jia Jingru Li Zongliang Jiang Source Type: research
Feasibility of precision smoking treatment in a low-income community setting: results of a pilot randomized controlled trial in The Southern Community Cohort Study
CONCLUSIONS: Genetically informed precision smoking cessation interventions are feasible in socioeconomically disadvantaged communities, exhibiting high enrollment, engagement, and retention irrespective of race, sex, income, education, or attitudes toward precision smoking treatment. Future smoking cessation interventions in this population should take steps to engage older people and to sustain participation in interventions that include genetic risk counseling.TRIAL REGISTRATION: ClinicalTrials.gov No. NCT03521141, Registered 27 April 2018, https://www.CLINICALTRIALS: gov/study/NCT03521141.PMID:38491559 | PMC:PMC1094144...
Source: Clinical Lung Cancer - March 16, 2024 Category: Cancer & Oncology Authors: Scott S Lee Nicole Senft Everson Maureen Sanderson Rebecca Selove William J Blot Stephen King Karen Gilliam Suman Kundu Mark Steinwandel Sarah J Sternlieb Qiuyin Cai Shaneda Warren Andersen Debra L Friedman Erin Connors Kelly Mary Kay Fadden Matthew S Fre Source Type: research
Comparison of PD-L1 (22C3) Expression in Paired Primary and Metastatic Breast Carcinoma
CONCLUSION: Our study showed a decrease in PD-L1 expression and disconnected molecular features during breast cancer progression. Repeating PD-L1 IHC testing could be considered in some specific metastatic sites if primary tumors were negative. Further studies are needed to identify other predictive factors for immune checkpoint inhibitor (ICI) therapy in patients with breast carcinoma.PMID:38492995 | DOI:10.1016/j.clbc.2024.02.010 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - March 16, 2024 Category: Cancer & Oncology Authors: Xiao Huang Sarah A Anderson Gene P Siegal Shi Wei Shanrun Liu Jingyun Yang Puentes Roisin J Taylor Pickens Lei Huo Aysegul A Sahin Carlos Prieto Granada Shuojun Chen Source Type: research
The diagnostic and prognostic value of exosomal microRNAs in lung cancer: a systematic review
CONCLUSIONS: Exosomal miRNAs are valuable biomarkers in lung cancer patients. Exosomal miR-486-5p and miR-451a can be used as new diagnostic biomarkers for lung cancer. Dysregulated exosomal miRNAs could serve as indicators of survival outcomes in lung cancer patients.PMID:38485857 | DOI:10.1007/s12094-024-03414-7 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - March 15, 2024 Category: Cancer & Oncology Authors: Bingbing Yang Xiaoqi Xin Xiaoqing Cao Lubanga Nasifu Zhenlin Nie Bangshun He Source Type: research
