Preoperative nomogram for predicting spread through air spaces in clinical-stage IA non-small cell lung cancer using (18)F-fluorodeoxyglucose positron emission tomography/computed tomography
CONCLUSION: Our nomogram based on preoperative 18F-FDG PET/CT radiological features and SUVmax effectively predicts STAS status in clinical-stage IA NSCLC. Furthermore, our study highlights that metabolic parameters and CT variables associated with STAS differ between solid and part-solid nodular NSCLC.PMID:38598007 | DOI:10.1007/s00432-024-05674-w (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Yun Wang Deng Lyu Chao Cheng Taohu Zhou Wenting Tu Yi Xiao Changjing Zuo Li Fan Shiyuan Liu Source Type: research
Impact of concurrent medications on clinical outcomes of cancer patients treated with immune checkpoint inhibitors: analysis of Health Insurance Review and Assessment data
CONCLUSION: A high number of concurrent medications was associated with poor clinical outcomes.PMID:38600328 | DOI:10.1007/s00432-024-05728-z (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Soojung Hong Ju Hyun Lee Ja Yoon Heo Koung Jin Suh Se Hyun Kim Yu Jung Kim Jee Hyun Kim Source Type: research
Progressive changes in the protein expression profile of alveolar septa in early-stage lung adenocarcinoma
CONCLUSIONS: FAP-positive fibroblasts may contribute to tumor stroma formation in early-stage lung adenocarcinoma, and this could influence the development of therapeutic strategies targeting FAP-positive CAFs for disrupting extracellular matrix formation.PMID:38600426 | DOI:10.1007/s10147-024-02507-1 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Toru Kimura Takashi Akazawa Yu Mizote Harumi Nakamura Miki Sakaue Tomohiro Maniwa Yasushi Shintani Keiichiro Honma Hideaki Tahara Jiro Okami Source Type: research
Impact of proton PBS machine operating parameters on the effectiveness of layer rescanning for interplay effect mitigation in lung SBRT treatment
CONCLUSION: The effectiveness of layer rescanning for mitigating interplay effect is affected by machine operating parameters. Therefore, past clinical experiences may not be applicable to modern machines.PMID:38590112 | DOI:10.1002/acm2.14342 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Xiaoying Liang Chunbo Liu Jiajian Shen Stella Flampouri Justin C Park Bo Lu Sridhar Yaddanapudi Jun Tan Keith M Furutani Chris J Beltran Source Type: research
Stereotactic ablative radiotherapy for treating primary head and neck cancer and locoregional recurrence: A comprehensive review of the literature
CONCLUSIONS: SABR is an innovative, effective and promising treatment modality for small targets, especially in near proximity to organs at risk or in a pre-irradiated region. Prospective trials are further needed for this technique to become standard-of care.PMID:38590327 | PMC:PMC10999469 | DOI:10.1016/j.ctro.2024.100766 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Ciro Franzese Panagiotis Balermpas Source Type: research
Heart and Lung Dose as Predictors of Overall Survival in Patients With Locally Advanced Lung Cancer. A National Multicenter Study
CONCLUSIONS: Besides the classic noncardiac risk factors, lung and heart doses had a negative impact on survival, while it is suggested that the left side of the heart is a more radiation dose-sensitive region. The data indicate that overall heart irradiation should be reduced to improve the OS if possible.PMID:38590728 | PMC:PMC10999485 | DOI:10.1016/j.jtocrr.2024.100663 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Agon Olloni Carsten Brink Ebbe Laugaard Lorenzen Stefan Starup Jeppesen Lone Hofmann Charlotte Kristiansen Marianne Marquard Knap Ditte Sloth M øller Lotte Nyg ård Gitte Fredberg Persson Rune Slot Thing Hella Maria Br øgger Sand Axel Diederichsen Tine Source Type: research
Significantly Elevated CA 19-9 after COVID-19 Vaccination and Literature Review of Non-Cancerous Cases with CA 19-9 & gt; 1000 U/mL
CONCLUSIONS: Conducting differential diagnosis, it should not be forgotten that most international guidelines recommend the use of CA 19-9 only in conjunction with pathology of pancreas in radiological imaging; however, even such a combination can point the diagnostic pathway in the wrong direction. A highly elevated CA 19-9 level, typically associated with PDAC, may be the result of benign disease including AIP related to COVID-19 vaccination.PMID:38592088 | PMC:PMC10932348 | DOI:10.3390/jcm13051263 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Jakub Ciesielka Krzysztof Jakim ów Natalia Tekiela Laura Peisert Anna Kwa śniewska Dariusz Kata Jerzy Chudek Source Type: research
Orchestrating Resilience: How Neuropilin-2 and Macrophages Contribute to Cardiothoracic Disease
J Clin Med. 2024 Mar 1;13(5):1446. doi: 10.3390/jcm13051446.ABSTRACTImmunity has evolved to balance the destructive nature of inflammation with wound healing to overcome trauma, infection, environmental insults, and rogue malignant cells. The inflammatory response is marked by overlapping phases of initiation, resolution, and post-resolution remodeling. However, the disruption of these events can lead to prolonged tissue damage and organ dysfunction, resulting long-term disease states. Macrophages are the archetypic phagocytes present within all tissues and are important contributors to these processes. Pleiotropic and hig...
Source: Clinical Lung Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Rajeev Dhupar Amy A Powers Seth H Eisenberg Robert M Gemmill Charles E Bardawil Hannah M Udoh Andrea Cubitt Leslie A Nangle Adam C Soloff Source Type: research
Lung Cancer in Women-Sociodemographic, Clinical and Psychological Characteristics with Comparison to Men
Conclusions: We should be more active in finding out the willingness to consult a psychologist or psychiatrist among women with lung cancer. The diagnosis of COPD should be considered more often among women due to the lack of differences in the reported incidence of COPD between men and women, despite a clear contrast in the number of pack-years.PMID:38592288 | PMC:PMC10934020 | DOI:10.3390/jcm13051450 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Anna Trojnar Magdalena Knetki-Wr óblewska Piotr Sobieraj Joanna Domaga ła-Kulawik Source Type: research
Enhancing Immune Response in Non-Small-Cell Lung Cancer Patients: Impact of the 13-Valent Pneumococcal Conjugate Vaccine
Conclusions: We hope that our research will contribute to increasing patients' and physicians' awareness of the importance of including PCV13 vaccinations in the standard of oncological care, which will extend the survival time of patients and improve their quality of life.PMID:38592328 | PMC:PMC10933946 | DOI:10.3390/jcm13051520 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Jolanta Smok-Kalwat Paulina Mertowska Izabela Korona-G łowniak Sebastian Mertowski Paulina Nied źwiedzka-Rystwej Dominika B ębnowska Krzysztof Gosik Andrzej Stepulak Stanis ław Góźdź Jacek Roli ński Zofia G órecka Jan Siwiec Ewelina Grywalska Source Type: research
A Systemic Immune Inflammation Index and PD-L1 (SP142) Expression as a Potential Combined Biomarker of the Clinical Benefit of Chemo-Immunotherapy in Extensive-Stage Small-Cell Lung Cancer
Conclusions: The combined SII-SP142 biomarker can be readily and universally obtained at a low cost in clinical practice, without requiring advanced genomics technology or specialized expertise. Although further studies are needed to confirm that the combined SII-SP142 biomarker is widely applicable, it should help clinicians to identify the best patients for combined chemotherapy with atezolizumab in ES-SCLC.PMID:38592329 | PMC:PMC10932321 | DOI:10.3390/jcm13051521 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Jong-Min Baek Hyungkeun Cha Yeonsook Moon Lucia Kim Seung Min Kwak Eun Sun Park Hae-Seong Nam Source Type: research
Glioblastoma and Internal Carotid Artery Calcium Score: A Possible Novel Prognostic Partnership?
Conclusions: the ICA calcium score could be a promising prognostic biomarker in GBM patients.PMID:38592330 | PMC:PMC10933913 | DOI:10.3390/jcm13051512 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Francesco Pasqualetti Michela Gabelloni Lorenzo Faggioni Giovanni Donato Aquaro Fabrizio De Vietro Vincenzo Mendola Nicola Spina Jessica Frey Nicola Montemurro Martina Cantarella Mario Caccese Giovanni Gadducci Noemi Giannini Silvia Valenti Riccardo Morga Source Type: research
Nicotinamide in Combination with EGFR-TKIs for the Treatment of Stage IV Lung Adenocarcinoma with EGFR Mutations: A Randomized Double-Blind (Phase IIb) Trial
CONCLUSIONS: The addition of nicotinamide with EGFR-TKIs demonstrated potential improvements in PFS and OS, with notable survival benefits for female patients and those who had never smoked (ClinicalTrials.gov Identifier: NCT02416739).PMID:38593249 | DOI:10.1158/1078-0432.CCR-23-3059 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Hyung-Joo Oh Suk-Chul Bae In-Jae Oh Cheol-Kyu Park Kyoung-Mi Jung Da-Mi Kim Jung-Won Lee Chang Kyun Kang Il Yeong Park Young-Chul Kim Source Type: research
A phenotypic screening approach to target p60AmotL2-expressing invasive cancer cells
CONCLUSIONS: BET inhibitors specifically target p60AmotL2-expressing invasive cancer cells, likely by exploiting differences in chromatin accessibility, leading to cell death. Additionally, our findings support the use of this phenotypic strategy to discover novel compounds that can exploit vulnerabilities and specifically target invasive cancer cells.PMID:38594748 | PMC:PMC11003180 | DOI:10.1186/s13046-024-03031-w (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Pedro Fonseca Weiyingqi Cui Nona Struyf Le Tong Ayushi Chaurasiya Felipe Casagrande Honglei Zhao Dinura Fernando Xinsong Chen Nicholas P Tobin Brinton Seashore-Ludlow Andreas Lundqvist Johan Hartman Anita G öndör P äivi Östling Lars Holmgren Source Type: research
Impact of proton PBS machine operating parameters on the effectiveness of layer rescanning for interplay effect mitigation in lung SBRT treatment
CONCLUSION: The effectiveness of layer rescanning for mitigating interplay effect is affected by machine operating parameters. Therefore, past clinical experiences may not be applicable to modern machines.PMID:38590112 | DOI:10.1002/acm2.14342 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Xiaoying Liang Chunbo Liu Jiajian Shen Stella Flampouri Justin C Park Bo Lu Sridhar Yaddanapudi Jun Tan Keith M Furutani Chris J Beltran Source Type: research
