Macranthoidin B (MB) Promotes Oxidative Stress-Induced Inhibiting of Hepa1-6 Cell Proliferation via Selenoprotein
In conclusion, MB dose dependently inhibited hepa1-6 cell proliferation and induced oxidative stress. Based on bioinformatics analysis, with MB treatment, Txnrd 3, Selk, Selo, Selw, Selt, Dio2, Txnrd1, Dio3, Gpx6, and Dio1 exhibited critical role in the inhibition of hepa1-6 cells proliferation. The functions of these selenoproteins were associated with oxidative stress.PMID:35080709 | DOI:10.1007/s12011-022-03120-x (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 26, 2022 Category: Biology Authors: Siran Tan Qi Liu Jie Yang Jingzeng Cai Miao Yu Yubin Ji Source Type: research

Lithium Chloride Promotes Milk Protein and Fat Synthesis in Bovine Mammary Epithelial Cells via HIF-1 α and β-Catenin Signaling Pathways
Biol Trace Elem Res. 2022 Jan 26. doi: 10.1007/s12011-022-03131-8. Online ahead of print.ABSTRACTLithium is one of the trace elements with many physiological properties, such as being anti-cancer, anti-viral, and anti-inflammatory. However, little is known about its effect on milk synthesis during lactation. Therefore, we selected different concentrations (5 mM, 10 mM, and 20 mM) of lithium chloride (LiCl) and assessed the effect of LiCl on bovine mammary epithelial (MAC-T) cells that underwent 4 days of differentiation induction. Moreover, we analyzed the effect of LiCl on the expression of genes related to milk fat and m...
Source: Biological Trace Element Research - January 26, 2022 Category: Biology Authors: Jinxin Zong Jinglin Shen Xinlu Liu Jiayi Liu Jing Zhang Changhai Zhou Yating Fan Yongcheng Jin Source Type: research

Correlation Between Drinking Water and Iodine Status: a Systematic Review and Meta-analysis
Biol Trace Elem Res. 2022 Jan 24. doi: 10.1007/s12011-022-03127-4. Online ahead of print.ABSTRACTIodine is a micronutrient essential for maintaining normal body functioning, and the consumption depends on the distribution in the environment, and insufficient or excessive intake results in thyroid dysfunction. The purpose of this review was to evaluate the correlation between iodine concentration in drinking water and the iodine status of the population. The systematic review was conducted following the PRISMA guidelines and was registered at the International Prospective Register of Ongoing Systematic Reviews (CRD420191283...
Source: Biological Trace Element Research - January 25, 2022 Category: Biology Authors: Francilene Maria Azevedo Almeida Abudo Leite Machamba Aline Carare Candido Carina Aparecida Pinto S ílvia Oliveira Lopes Mariana de Souza Macedo Sarah Aparecida Vieira Ribeiro Silvia Eloiza Priore Sylvia do Carmo Castro Franceschini Source Type: research

Paclitaxel Promotes Oxidative Stress-Mediated Human Laryngeal Squamous Tumor Cell Death through the Stimulation of Calcium and Zinc Signaling Pathways: No Synergic Action of Melatonin
In conclusion, PAX induced the increase of Hep2 cell death via upregulations of TRPM2 and Zn2+, although its downregulation via the treatment of MLT did not change the antitumor action of PAX.PMID:35075596 | DOI:10.1007/s12011-022-03125-6 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 25, 2022 Category: Biology Authors: Yusuf Çağdaş Kumbul Mustafa Naz ıroğlu Source Type: research

Gpx4, Selenov, and Txnrd3 Are Three Most Testis-Abundant Selenogenes Resistant to Dietary Selenium Concentrations and Actively Expressed During Reproductive Ages in Rats
This study aimed to profile the mRNA expressions of the testis-abundant selenogenes of rat models in responses to growth and dietary Se concentrations. Forty-eight weaning SD male rats were fed Se deficient basal diet (BD) for 5 weeks and then randomly grouped (n = 12/group) for being fed BD or BD plus 0.25, 3, or 5 mg Se/kg for 4 more weeks before sacrifice. Abundances of selenogenomic mRNAs in the liver and testis were determined with relative qPCR and those of the testis-abundant selenogenes in 13 kinds of tissues were assayed with a molecular beacon-based qPCR. Spatiotemporal expressions of rat selenogenome were also a...
Source: Biological Trace Element Research - January 25, 2022 Category: Biology Authors: Aiping Liu Fengna Li Ping Xu Yanmei Chen Xiongshun Liang Shijie Zheng Huicui Meng Yumei Zhu Junluan Mo Chunmei Gong Ji-Chang Zhou Source Type: research

Cadmium and Lead Concentration in Drinking Instant Coffee, Instant Coffee Drinks and Coffee Substitutes: Safety and Health Risk Assessment
Biol Trace Elem Res. 2022 Jan 25. doi: 10.1007/s12011-022-03129-2. Online ahead of print.ABSTRACTThe presence of heavy metals in food is a global problem. The paper aimed to examine the content of cadmium (Cd) and lead (Pb) in instant coffee and instant coffee substitutes. The safety of consumption of the beverages by adult Poles was estimated based on the following parameters: tolerable weekly intake (TWI) %, benchmark dose lower confidence limit (BMDL) %, chronic daily intake (CDI), target hazard quotient (THQ) and hazard index (HI), for three beverage consumption patterns-one, two or three servings a day. Forty-nine sam...
Source: Biological Trace Element Research - January 25, 2022 Category: Biology Authors: Anna Winiarska-Mieczan Karolina Jachimowicz Svitlana Kislova Ma łgorzata Kwiecień Zvenyslava Zasadna Dmytro Yanovych Source Type: research

Correlation Between Drinking Water and Iodine Status: a Systematic Review and Meta-analysis
Biol Trace Elem Res. 2022 Jan 24. doi: 10.1007/s12011-022-03127-4. Online ahead of print.ABSTRACTIodine is a micronutrient essential for maintaining normal body functioning, and the consumption depends on the distribution in the environment, and insufficient or excessive intake results in thyroid dysfunction. The purpose of this review was to evaluate the correlation between iodine concentration in drinking water and the iodine status of the population. The systematic review was conducted following the PRISMA guidelines and was registered at the International Prospective Register of Ongoing Systematic Reviews (CRD420191283...
Source: Biological Trace Element Research - January 25, 2022 Category: Biology Authors: Francilene Maria Azevedo Almeida Abudo Leite Machamba Aline Carare Candido Carina Aparecida Pinto S ílvia Oliveira Lopes Mariana de Souza Macedo Sarah Aparecida Vieira Ribeiro Silvia Eloiza Priore Sylvia do Carmo Castro Franceschini Source Type: research

Paclitaxel Promotes Oxidative Stress-Mediated Human Laryngeal Squamous Tumor Cell Death through the Stimulation of Calcium and Zinc Signaling Pathways: No Synergic Action of Melatonin
In conclusion, PAX induced the increase of Hep2 cell death via upregulations of TRPM2 and Zn2+, although its downregulation via the treatment of MLT did not change the antitumor action of PAX.PMID:35075596 | DOI:10.1007/s12011-022-03125-6 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 25, 2022 Category: Biology Authors: Yusuf Çağdaş Kumbul Mustafa Naz ıroğlu Source Type: research

Sex-Specific Association Between Iron Status and the Predicted 10-Year Risk for Atherosclerotic Cardiovascular Disease in Hypertensive Patients
Biol Trace Elem Res. 2022 Jan 24. doi: 10.1007/s12011-021-03060-y. Online ahead of print.ABSTRACTSerum ferritin (SF) and haemoglobin (Hb) are widely used in clinical practice to assess iron status. Studies exploring the relationship of SF and Hb with atherosclerotic cardiovascular disease (ASCVD) risk have yielded conflicting results, and some indicated sex specificity. Hypertensive patients have abnormal iron status. However, research on patients with hypertension is limited. We aim to investigate the sex-specific links of SF and Hb with the predicted 10-year ASCVD risk in hypertensive patients. This cross-sectional study...
Source: Biological Trace Element Research - January 24, 2022 Category: Biology Authors: Juan Zhou Rui Zhao Dongxia Wang Qin Gao Dan Zhao Binfa Ouyang Liping Hao Xiaolin Peng Source Type: research

Possible Association Between Polymorphisms in ESR1, COL1A2, BGLAP, SPARC, VDR, and MMP2 Genes and Dental Fluorosis in a Population from an Endemic Region of West Bengal
Biol Trace Elem Res. 2022 Jan 23. doi: 10.1007/s12011-021-03072-8. Online ahead of print.ABSTRACTDental fluorosis (DF) is the most prevalent form of fluorosis in India affecting millions of people all over the country. As estrogen receptor 1 (ESR1), collagen type 1 alpha 2 (COL1A2), bone γ-carboxyglutamic acid protein (BGLAP), secreted protein acidic and cysteine-rich (SPARC), vitamin D receptor (VDR), and matrix metallopeptidase 2 (MMP2) genes play critical roles in bone metabolism, bone formation, mineral metabolism, and mineralization, variants in these genes could influence susceptibility to DF. The present study...
Source: Biological Trace Element Research - January 23, 2022 Category: Biology Authors: Arijit Chakraborty Sreemanta Pramanik Kallol Datta Rakesh Goswami Depanwita Saha Kunal Kanti Majumdar Nilabja Sikdar Source Type: research

Nephroprotective Efficacy of Selenium and Zinc Against Potassium Dichromate-Induced Renal Toxicity in Pregnant Wistar Albino Rats
Biol Trace Elem Res. 2022 Jan 23. doi: 10.1007/s12011-021-03069-3. Online ahead of print.ABSTRACTHexavalent chromium (CrVI) compounds are potent toxicants commonly used in numerous industries. Thus, potential toxic effects and health hazards are of high relevance. Selenium (Se) and zinc (Zn) are known for their antioxidant and chemoprotective properties. However, little is known about their protective effects against CrVI-induced renal damage during pregnancy. In this context, the present study aimed to investigate the protective efficacy of these two essential elements against potassium dichromate-induced nephrotoxicity i...
Source: Biological Trace Element Research - January 23, 2022 Category: Biology Authors: Anfal Fedala Ounassa Adjroud Omar Bennoune Salwa Abid-Essefi Abdelhamid Foughalia Rim Timoumi Source Type: research

Selenite Ameliorates Cadmium-induced Cytotoxicity Through Downregulation of ROS Levels and Upregulation of Selenoprotein Thioredoxin Reductase 1 in SH-SY5Y Cells
This study may be a valuable reference for shedding light on the mechanism of Cd-induced cytotoxicity and the role of TrxR1 in Se-mitigated cytotoxicity of Cd in neuroblast cells, which may be helpful for understanding the therapeutic potential of Cd and Se in treating or preventing neurodegenerative diseases, like Alzheimer's disease (AD) and Parkinson's disease (PD).PMID:35066751 | DOI:10.1007/s12011-022-03117-6 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 23, 2022 Category: Biology Authors: Hecheng Wang Shibo Sun Yan Ren Rui Yang Jianli Guo Yu Zong Qiuxian Zhang Jing Zhao Wei Zhang Weiping Xu Shui Guan Jianqiang Xu Source Type: research

Possible Association Between Polymorphisms in ESR1, COL1A2, BGLAP, SPARC, VDR, and MMP2 Genes and Dental Fluorosis in a Population from an Endemic Region of West Bengal
Biol Trace Elem Res. 2022 Jan 23. doi: 10.1007/s12011-021-03072-8. Online ahead of print.ABSTRACTDental fluorosis (DF) is the most prevalent form of fluorosis in India affecting millions of people all over the country. As estrogen receptor 1 (ESR1), collagen type 1 alpha 2 (COL1A2), bone γ-carboxyglutamic acid protein (BGLAP), secreted protein acidic and cysteine-rich (SPARC), vitamin D receptor (VDR), and matrix metallopeptidase 2 (MMP2) genes play critical roles in bone metabolism, bone formation, mineral metabolism, and mineralization, variants in these genes could influence susceptibility to DF. The present study...
Source: Biological Trace Element Research - January 23, 2022 Category: Biology Authors: Arijit Chakraborty Sreemanta Pramanik Kallol Datta Rakesh Goswami Depanwita Saha Kunal Kanti Majumdar Nilabja Sikdar Source Type: research

Nephroprotective Efficacy of Selenium and Zinc Against Potassium Dichromate-Induced Renal Toxicity in Pregnant Wistar Albino Rats
Biol Trace Elem Res. 2022 Jan 23. doi: 10.1007/s12011-021-03069-3. Online ahead of print.ABSTRACTHexavalent chromium (CrVI) compounds are potent toxicants commonly used in numerous industries. Thus, potential toxic effects and health hazards are of high relevance. Selenium (Se) and zinc (Zn) are known for their antioxidant and chemoprotective properties. However, little is known about their protective effects against CrVI-induced renal damage during pregnancy. In this context, the present study aimed to investigate the protective efficacy of these two essential elements against potassium dichromate-induced nephrotoxicity i...
Source: Biological Trace Element Research - January 23, 2022 Category: Biology Authors: Anfal Fedala Ounassa Adjroud Omar Bennoune Salwa Abid-Essefi Abdelhamid Foughalia Rim Timoumi Source Type: research

Selenite Ameliorates Cadmium-induced Cytotoxicity Through Downregulation of ROS Levels and Upregulation of Selenoprotein Thioredoxin Reductase 1 in SH-SY5Y Cells
This study may be a valuable reference for shedding light on the mechanism of Cd-induced cytotoxicity and the role of TrxR1 in Se-mitigated cytotoxicity of Cd in neuroblast cells, which may be helpful for understanding the therapeutic potential of Cd and Se in treating or preventing neurodegenerative diseases, like Alzheimer's disease (AD) and Parkinson's disease (PD).PMID:35066751 | DOI:10.1007/s12011-022-03117-6 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 23, 2022 Category: Biology Authors: Hecheng Wang Shibo Sun Yan Ren Rui Yang Jianli Guo Yu Zong Qiuxian Zhang Jing Zhao Wei Zhang Weiping Xu Shui Guan Jianqiang Xu Source Type: research

Comparative Analysis of Serum Zinc, Copper and Magnesium Level and Their Relations in Association with Severity and Mortality in SARS-CoV-2 Patients
Biol Trace Elem Res. 2022 Jan 22. doi: 10.1007/s12011-022-03124-7. Online ahead of print.ABSTRACTThe deficiencies of trace elements and infectious diseases often coexist and exhibit complex interactions. Several trace elements such as zinc (Zn), copper (Cu) and magnesium (Mg) have immunomodulatory functions and thus influence the susceptibility to the course and outcome of a variety of viral infections. So, this present study was aimed to study relations of trace metals in association with severity and mortality in SARS-CoV-2 patients. A total of 150 individuals infected with COVID-19 and 50 healthy individuals were recrui...
Source: Biological Trace Element Research - January 22, 2022 Category: Biology Authors: Kiran Kumar Pvsn Sojit Tomo Purvi Purohit Shrimanjunath Sankanagoudar Jayakaran Charan Abhishek Purohit Vijaylakshami Nag Pradeep Bhatia Kuldeep Singh Naveen Dutt Mahendra Kumar Garg Praveen Sharma Sanjeev Misra Dharamveer Yadav Source Type: research

Characteristics of Zn Content and Localization, Cu-Zn SOD, and MT Levels in the Tissues of Marginally Zn-Deficient Mice
The objective of the present study was to compare the content and distribution of Zn and the change in the copper (Cu)-Zn superoxide dismutase (SOD) and metallothionein (MT) levels of soft tissues. Mice were fed with 30 mg/kg (control) or 10 mg/kg (marginally Zn-deficient, MZD) Zn diet for 35 days. We observed that only the Zn contents of serum, bones, and muscles in the control group were higher than those in the MZD group. Autometallography (AMG) was used as a method for staining Zn ions, and the semi-quantitative result indicated that the AMG products of the liver, duodenum, heart, lung, testes, and epididymis in the co...
Source: Biological Trace Element Research - January 22, 2022 Category: Biology Authors: Ziqiong Wang Cheng Peng Yuting Zhang Lei Wang Lu Yu Chunhong Wang Source Type: research

Ginkgo biloba Extract Attenuates the Disruption of Pro- and Anti-inflammatory Balance of Peripheral Blood in Arsenism Patients by Decreasing Hypermethylation of the Foxp3 Promoter Region
Biol Trace Elem Res. 2022 Jan 22. doi: 10.1007/s12011-022-03101-0. Online ahead of print.ABSTRACTCoal-burning type of arsenism, a chronic arsenism caused by environmental arsenic pollution, found firstly at Guizhou Province of China, manifested as the disruption of pro- and anti-inflammatory T cell balance and multiple organ damage, while no specific treatment for the arsenism patients. The effect of methylation of the forkhead box P3 (Foxp3) promoter region on arsenic-induced disruption of pro- and anti-inflammatory T cell balance was first evaluated in this study, between the control and arsenism groups. The results show...
Source: Biological Trace Element Research - January 22, 2022 Category: Biology Authors: Xiaolin Fang Qibing Zeng Baofei Sun Shaofeng Wei Zhonglan Zou Shiqing Xia Peng Luo Aihua Zhang Source Type: research

Comparative Analysis of Serum Zinc, Copper and Magnesium Level and Their Relations in Association with Severity and Mortality in SARS-CoV-2 Patients
Biol Trace Elem Res. 2022 Jan 22. doi: 10.1007/s12011-022-03124-7. Online ahead of print.ABSTRACTThe deficiencies of trace elements and infectious diseases often coexist and exhibit complex interactions. Several trace elements such as zinc (Zn), copper (Cu) and magnesium (Mg) have immunomodulatory functions and thus influence the susceptibility to the course and outcome of a variety of viral infections. So, this present study was aimed to study relations of trace metals in association with severity and mortality in SARS-CoV-2 patients. A total of 150 individuals infected with COVID-19 and 50 healthy individuals were recrui...
Source: Biological Trace Element Research - January 22, 2022 Category: Biology Authors: Kiran Kumar Pvsn Sojit Tomo Purvi Purohit Shrimanjunath Sankanagoudar Jayakaran Charan Abhishek Purohit Vijaylakshami Nag Pradeep Bhatia Kuldeep Singh Naveen Dutt Mahendra Kumar Garg Praveen Sharma Sanjeev Misra Dharamveer Yadav Source Type: research

Resveratrol-Selenium Nanoparticles Alleviate Neuroinflammation and Neurotoxicity in a Rat Model of Alzheimer's Disease by Regulating Sirt1/miRNA-134/GSK3 β Expression
Biol Trace Elem Res. 2022 Jan 21. doi: 10.1007/s12011-021-03073-7. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a brain disorder associated with a gradual weakening in neurocognitive functions, neuroinflammation, and impaired signaling pathways. Resveratrol (RSV) has neuroprotective properties, but with low bioavailability, and low solubility in vivo. Selenium (Se) is an essential micronutrient for brain function. Thus, this study aimed to evaluate the role of formulated RSV-Se nanoparticles (RSV-SeNPs) on neurochemical and histopathological approaches associated with the AD model in rats induced by Aluminum c...
Source: Biological Trace Element Research - January 21, 2022 Category: Biology Authors: Omayma A R Abozaid Mohsen W Sallam Sawsan El-Sonbaty Samy Aziza Basma Emad Esraa S A Ahmed Source Type: research

Effect of Astaxanthin and Copper Supplementation on Growth, Immunity, Antioxidant, and Blood Biochemical Status of Growing Murrah Buffalo Heifers
This study was aimed to explore the effect of astaxanthin (ASTX) and copper (Cu) supplementation on the growth, immunity, antioxidant, and blood biochemical status of growing Murrah buffalo heifers. Twenty-eight Murrah buffalo heifers were selected and randomly divided into 4 groups (n = 7) after blocking by body weight (BW) (129.86 ± 5.37 kg) and age (9.05 ± 1.02 months). The heifers were fed basal total mixed ration diet without supplementation (CON) or with ASTX (0.20 mg/kg BW; AX), Cu (10 mg/kg DM; CU), or ASTX + Cu (0.20 mg/kg BW + 10 mg/kg DM; AX + CU) for 90 days of study period. The result showed that...
Source: Biological Trace Element Research - January 21, 2022 Category: Biology Authors: Rajesh Kumar Deo Saran Sahu Gulab Chandra Satya Prakash Yadav Raj Kumar Nazim Ali Debashis Roy Prem Sagar Maurya Source Type: research

Iodine Supplementation Improved Antioxidant Status, Hormonal Status, Sexual Behavior, and Semen Production Performance of Bos indicus Bulls Under Tropical Climatic Condition
Biol Trace Elem Res. 2022 Jan 20. doi: 10.1007/s12011-021-03066-6. Online ahead of print.ABSTRACTIodine is anessential micronutrient that plays a crucial role in male reproduction (sexual behavior and semen production performance) by modulating thyroid function and the antioxidant status of the animal. Nonetheless, in Bos indicus bulls, a thorough evaluation of the effects of dietary iodine supplementation on antioxidant status, seminal quality parameters, and its interaction with other minerals is not documented. Twelve Bos indicus (Sahiwal) bulls were distributed into three groups (n = 4 in each group) viz. T1 (control),...
Source: Biological Trace Element Research - January 20, 2022 Category: Biology Authors: Rashika Srivastava Saurabh Tiwari P S Banakar Mukesh Bhakat Veena Mani T K Mohanty Goutam Mondal Source Type: research

Is There Correlation Between Aluminum-Based Food Consumption and Plasma Level in Pregnant Women?
Biol Trace Elem Res. 2022 Jan 20. doi: 10.1007/s12011-021-03063-9. Online ahead of print.ABSTRACTTo explore the correlation of AL-based food consumption, known to have negative impact on health, and Al plasma levels with pregnancy status. A cross-sectional study was conducted on 75 participants, including 50 pregnant women. Al plasma levels were analyzed by ET-AAS. Exposure to food was positively correlated to Al mean plasma levels (reaching 2.12 ± 1.17 μg/L) by 32%, specifically for potatoes, fruits, soft drinks, and ready meals. Usage of Al cookware was associated to higher Al plasma levels while pregnancy stat...
Source: Biological Trace Element Research - January 20, 2022 Category: Biology Authors: Sarine El Daouk Alain Pineau M Fouad Ziade Raed Ezzeddine Akram Hijazi Mohamad Al Iskandarani Source Type: research

Systemic Essential Metal and Metalloid Levels in Patients with Benign Breast Disease and Breast Cancer
The objective of the present study is evaluation of serum and hair levels of essential metals and metalloids in women with benign breast disease and breast cancer in order to define similar and distinct patterns that may mediate the link between these pathologies. A total of 310 adult women aged 20-80 years old were enrolled in the present study. Of those, 103 patients had benign (fibrocystic) breast disease, 107 patients had breast cancer (stage II), and 100 women were healthy and with absence of breast pathology. Trace metal and metalloid levels in hair and serum were evaluated by inductively coupled argon plasma mass-sp...
Source: Biological Trace Element Research - January 20, 2022 Category: Biology Authors: Anatoly V Skalny Marina I Sekacheva Michael Aschner Yulia N Lobanova Alexey A Tinkov Source Type: research

Iodine Supplementation Improved Antioxidant Status, Hormonal Status, Sexual Behavior, and Semen Production Performance of Bos indicus Bulls Under Tropical Climatic Condition
Biol Trace Elem Res. 2022 Jan 20. doi: 10.1007/s12011-021-03066-6. Online ahead of print.ABSTRACTIodine is anessential micronutrient that plays a crucial role in male reproduction (sexual behavior and semen production performance) by modulating thyroid function and the antioxidant status of the animal. Nonetheless, in Bos indicus bulls, a thorough evaluation of the effects of dietary iodine supplementation on antioxidant status, seminal quality parameters, and its interaction with other minerals is not documented. Twelve Bos indicus (Sahiwal) bulls were distributed into three groups (n = 4 in each group) viz. T1 (control),...
Source: Biological Trace Element Research - January 20, 2022 Category: Biology Authors: Rashika Srivastava Saurabh Tiwari P S Banakar Mukesh Bhakat Veena Mani T K Mohanty Goutam Mondal Source Type: research

Is There Correlation Between Aluminum-Based Food Consumption and Plasma Level in Pregnant Women?
Biol Trace Elem Res. 2022 Jan 20. doi: 10.1007/s12011-021-03063-9. Online ahead of print.ABSTRACTTo explore the correlation of AL-based food consumption, known to have negative impact on health, and Al plasma levels with pregnancy status. A cross-sectional study was conducted on 75 participants, including 50 pregnant women. Al plasma levels were analyzed by ET-AAS. Exposure to food was positively correlated to Al mean plasma levels (reaching 2.12 ± 1.17 μg/L) by 32%, specifically for potatoes, fruits, soft drinks, and ready meals. Usage of Al cookware was associated to higher Al plasma levels while pregnancy stat...
Source: Biological Trace Element Research - January 20, 2022 Category: Biology Authors: Sarine El Daouk Alain Pineau M Fouad Ziade Raed Ezzeddine Akram Hijazi Mohamad Al Iskandarani Source Type: research

Systemic Essential Metal and Metalloid Levels in Patients with Benign Breast Disease and Breast Cancer
The objective of the present study is evaluation of serum and hair levels of essential metals and metalloids in women with benign breast disease and breast cancer in order to define similar and distinct patterns that may mediate the link between these pathologies. A total of 310 adult women aged 20-80 years old were enrolled in the present study. Of those, 103 patients had benign (fibrocystic) breast disease, 107 patients had breast cancer (stage II), and 100 women were healthy and with absence of breast pathology. Trace metal and metalloid levels in hair and serum were evaluated by inductively coupled argon plasma mass-sp...
Source: Biological Trace Element Research - January 20, 2022 Category: Biology Authors: Anatoly V Skalny Marina I Sekacheva Michael Aschner Yulia N Lobanova Alexey A Tinkov Source Type: research

Effects of Dietary Supplementation with Green-Synthesized Zinc Oxide Nanoparticles for Candidiasis Control in Oreochromis niloticus
Biol Trace Elem Res. 2022 Jan 18. doi: 10.1007/s12011-021-02985-8. Online ahead of print.ABSTRACTZinc is an essential element for metabolism of Nile tilapia (Oreochromis niloticus). Nanomaterials have important benefits in aquaculture. The present study evaluated the effects of green-synthesized zinc oxide nanoparticles (ZnO-NPs) using Ulva fasciata extract as an anti-fungal agent against Candida albicans (C. albicans) in vitro and in vivo in O. niloticus. A total of 252 apparent healthy O. niloticus (20 ± 0.457 g/fish) were randomly allocated into six groups: The 1st group fed on basal diet contaminated with C. alb...
Source: Biological Trace Element Research - January 18, 2022 Category: Biology Authors: Amany M Diab Basma T Shokr Mustafa Shukry Foad A Farrag Radi A Mohamed Source Type: research

Effects of Dietary Supplementation with Green-Synthesized Zinc Oxide Nanoparticles for Candidiasis Control in Oreochromis niloticus
Biol Trace Elem Res. 2022 Jan 18. doi: 10.1007/s12011-021-02985-8. Online ahead of print.ABSTRACTZinc is an essential element for metabolism of Nile tilapia (Oreochromis niloticus). Nanomaterials have important benefits in aquaculture. The present study evaluated the effects of green-synthesized zinc oxide nanoparticles (ZnO-NPs) using Ulva fasciata extract as an anti-fungal agent against Candida albicans (C. albicans) in vitro and in vivo in O. niloticus. A total of 252 apparent healthy O. niloticus (20 ± 0.457 g/fish) were randomly allocated into six groups: The 1st group fed on basal diet contaminated with C. alb...
Source: Biological Trace Element Research - January 18, 2022 Category: Biology Authors: Amany M Diab Basma T Shokr Mustafa Shukry Foad A Farrag Radi A Mohamed Source Type: research

Ginkgo biloba Supplement Reverses Lead (II) Acetate-Induced Haematological Imbalances, and Hepatic and Renal Dysfunctions in Male Wistar Rat
Biol Trace Elem Res. 2022 Jan 17. doi: 10.1007/s12011-022-03098-6. Online ahead of print.ABSTRACTLead is a heavy metal abundant in nature that causes haematological imbalances, and hepatic and renal dysfunction, and this imbalance has been linked to oxidative stress. Several reports have shown that natural products are implicated in ameliorating metal poisonings. Ginkgo biloba is a flavonoid-rich natural herbal supplement with several pharmacological properties. The present study investigated effect of Ginkgo biloba supplement (GBS) on lead-induced toxicity. Animals were given a lead dose of 25 mg/kg for 14 days orally and...
Source: Biological Trace Element Research - January 17, 2022 Category: Biology Authors: Jerome Ndudi Asiwe Tarela Melish Elias Daubry Idara Asuquo Okon Ajirioghene Emamuzou Akpotu Ebunoluwa Oluwabusola Adagbada Harrison Eruotor Linda Chinyere Agbugba Buduchim Rejoice Buduburisi Source Type: research

Therapeutic Effects of Boric Acid in a Septic Arthritis Model Induced by Escherichia coli in Rats
Biol Trace Elem Res. 2022 Jan 16. doi: 10.1007/s12011-021-03065-7. Online ahead of print.ABSTRACTThe study aimed to evaluate the therapeutic effect of boric acid (BA) in experimentally induced septic arthritis. A total of 30 rats, 6 rats in each group (5 groups), were used in the study. No treatment was applied to the rats in the control group. Only BA was administered intraperitoneally (IP) to the rats in the bor group. Escherichia coli was administered at a single dose of 25 μL, 1 × 1010 cfu/rat from the right foot pad of the rats, via intra-articular route, to the mice in the arthritis, arthritis-bor, and arthr...
Source: Biological Trace Element Research - January 16, 2022 Category: Biology Authors: Kadri Y ıldız Mustafa Makav Yasemin Adal ı Menek şe Bulut Source Type: research

Selenium Deficiency Induces Apoptosis, Mitochondrial Dynamic Imbalance, and Inflammatory Responses in Calf Liver
Biol Trace Elem Res. 2022 Jan 16. doi: 10.1007/s12011-021-03059-5. Online ahead of print.ABSTRACTSelenium (Se) deficiency significantly impacts the cow breeding industry by reducing the milk quality of dairy cows and affecting the health of calves. The molecular mechanism of Se deficiency-induced damage to calves, however, remains unclear. The present study investigated whether Se deficiency induces oxidative stress, apoptosis, and inflammation in calf liver tissues. We collected the liver tissues of calves with Se deficiency. Experimental results showed that Se deficiency weakened the activity of antioxidant enzymes and i...
Source: Biological Trace Element Research - January 16, 2022 Category: Biology Authors: Shuang Wang Xingyao Liu Lei Lei Dong Wang Yun Liu Source Type: research

Therapeutic Effects of Boric Acid in a Septic Arthritis Model Induced by Escherichia coli in Rats
Biol Trace Elem Res. 2022 Jan 16. doi: 10.1007/s12011-021-03065-7. Online ahead of print.ABSTRACTThe study aimed to evaluate the therapeutic effect of boric acid (BA) in experimentally induced septic arthritis. A total of 30 rats, 6 rats in each group (5 groups), were used in the study. No treatment was applied to the rats in the control group. Only BA was administered intraperitoneally (IP) to the rats in the bor group. Escherichia coli was administered at a single dose of 25 μL, 1 × 1010 cfu/rat from the right foot pad of the rats, via intra-articular route, to the mice in the arthritis, arthritis-bor, and arthr...
Source: Biological Trace Element Research - January 16, 2022 Category: Biology Authors: Kadri Y ıldız Mustafa Makav Yasemin Adal ı Menek şe Bulut Source Type: research

Selenium Deficiency Induces Apoptosis, Mitochondrial Dynamic Imbalance, and Inflammatory Responses in Calf Liver
Biol Trace Elem Res. 2022 Jan 16. doi: 10.1007/s12011-021-03059-5. Online ahead of print.ABSTRACTSelenium (Se) deficiency significantly impacts the cow breeding industry by reducing the milk quality of dairy cows and affecting the health of calves. The molecular mechanism of Se deficiency-induced damage to calves, however, remains unclear. The present study investigated whether Se deficiency induces oxidative stress, apoptosis, and inflammation in calf liver tissues. We collected the liver tissues of calves with Se deficiency. Experimental results showed that Se deficiency weakened the activity of antioxidant enzymes and i...
Source: Biological Trace Element Research - January 16, 2022 Category: Biology Authors: Shuang Wang Xingyao Liu Lei Lei Dong Wang Yun Liu Source Type: research

Effects of the Seleno-Chitosan on Daily Gain, Wool Yield, and Blood Parameter in the Chinese Merino Sheep
Biol Trace Elem Res. 2022 Jan 15. doi: 10.1007/s12011-021-03049-7. Online ahead of print.ABSTRACTTo study the effects of the seleno-chitosan on daily gain, wool yield, and blood parameters in the Chinese merino sheep in the selenium (Se)-deficient pastures. The samples of soils, forages, and tissues had been collected in the Southern Xinjiang of Northwest China. Our findings indicated that the Se contents in soils and forages from affected pastures were remarkably lower than those unaffected by the pastures (P
Source: Biological Trace Element Research - January 15, 2022 Category: Biology Authors: Qionglian Zhang Yong Han Yang Yang Ping Zhou Xiaoyun Shen Source Type: research

Selenium Alleviates Chromium(VI)-Induced Ileum Damage and Cecal Microbial Disturbances in Mice
Biol Trace Elem Res. 2022 Jan 15. doi: 10.1007/s12011-021-03061-x. Online ahead of print.ABSTRACTHexavalent chromium [Cr(VI)] is one of the most common environmental contaminants caused by its broad industrial applications. Importantly, exposure to Cr(VI) induces oxidative damage and apoptosis in animal cells. Studies have shown that selenium (Se) can alleviate the toxic effects of Cr(VI) by functioning as an antioxidant and/or by chelating Cr(VI) into biologically inert complexes, but the underlying mechanism remains unknown. Here, we evaluated whether Se can ameliorate ileum damage and cecal microbial disturbances induce...
Source: Biological Trace Element Research - January 15, 2022 Category: Biology Authors: Yanbing Zhao Huan Zhang Dezheng Hao Jinglu Wang Ding Zhang Zilong Sun Ci Liu Source Type: research

Metals in Wild and Cultured Dicentrarchus labrax (Linnaeus, 1758) from Fish Markets in Sinop: Consumer's Health Risk Assessment
Biol Trace Elem Res. 2022 Jan 15. doi: 10.1007/s12011-021-03064-8. Online ahead of print.ABSTRACTConcentrations of Cd, Hg, Pb, As, Al, Cu, Fe, and Zn were determined in the muscles of wild and farmed European seabass in Sinop markets between September and December in 2020, using inductively coupled plasma mass spectrometry after microwave digestion. In the study, iron (Fe), zinc (Zn), aluminum (Al), and copper (Cu) were found higher than the other metals both in wild and cultured Dicentrarchus labrax. These are essential elements, but excess amounts act as a poison. Arsenic (As) concentration was higher than cadmium (Cd), ...
Source: Biological Trace Element Research - January 15, 2022 Category: Biology Authors: Levent Bat Fatih Şahin Md Simul Bhuyan Elif Arici Ay şah Öztekin Source Type: research

An Adequate Supply of Bis(ethylmaltolato)oxidovanadium(IV) Remarkably Reversed the Pathological Hallmarks of Alzheimer's Disease in Triple-Transgenic Middle-Aged Mice
Biol Trace Elem Res. 2022 Jan 15. doi: 10.1007/s12011-021-02938-1. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a complex and progressive neurodegenerative disease with impaired synapse, imbalanced mineral metabolism, protein mis-folding and aggregation. Bis(ethylmaltolato)oxidovanadium(IV) (BEOV), an organic bioactive vanadium compound with low toxicity and high bioavailability, has been studied as therapeutic agent against tuberculosis and diabetes. However, its neuroprotective effects have rarely been reported. Therefore, in this study, the potential application of BEOV in intervening AD cognitive dysfuncti...
Source: Biological Trace Element Research - January 15, 2022 Category: Biology Authors: Zhijun He Lin Zheng Xu Zhao Xiaoqian Li Hua Xue Qionghui Zhao Bingyu Ren Nan Li Jiazuan Ni Yan Zhang Qiong Liu Source Type: research

Tissue Distribution, Histopathological and Genotoxic Effects of Magnetite Nanoparticles on Ehrlich Solid Carcinoma
Biol Trace Elem Res. 2022 Jan 15. doi: 10.1007/s12011-022-03102-z. Online ahead of print.ABSTRACTNanoparticles can potentially cause adverse effects on cellular and molecular level. The present study aimed to investigate the histopathological changes and DNA damage effects of magnetite nanoparticles (MNPs) on female albino mice model with Ehrlich solid carcinoma (ESC). Magnetite nanoparticles coated with L-ascorbic acid (size ~ 25.0 nm) were synthesized and characterized. Mice were treated with MNPs day by day, intraperitoneally (IP), intramuscularly (IM), or intratumorally (IT). Autopsy samples were taken from the solid t...
Source: Biological Trace Element Research - January 15, 2022 Category: Biology Authors: Heba Bassiony Akmal A El-Ghor Taher A Salaheldin Salwa Sabet Mona M Mohamed Source Type: research

Effects of the Seleno-Chitosan on Daily Gain, Wool Yield, and Blood Parameter in the Chinese Merino Sheep
Biol Trace Elem Res. 2022 Jan 15. doi: 10.1007/s12011-021-03049-7. Online ahead of print.ABSTRACTTo study the effects of the seleno-chitosan on daily gain, wool yield, and blood parameters in the Chinese merino sheep in the selenium (Se)-deficient pastures. The samples of soils, forages, and tissues had been collected in the Southern Xinjiang of Northwest China. Our findings indicated that the Se contents in soils and forages from affected pastures were remarkably lower than those unaffected by the pastures (P
Source: Biological Trace Element Research - January 15, 2022 Category: Biology Authors: Qionglian Zhang Yong Han Yang Yang Ping Zhou Xiaoyun Shen Source Type: research

Selenium Alleviates Chromium(VI)-Induced Ileum Damage and Cecal Microbial Disturbances in Mice
Biol Trace Elem Res. 2022 Jan 15. doi: 10.1007/s12011-021-03061-x. Online ahead of print.ABSTRACTHexavalent chromium [Cr(VI)] is one of the most common environmental contaminants caused by its broad industrial applications. Importantly, exposure to Cr(VI) induces oxidative damage and apoptosis in animal cells. Studies have shown that selenium (Se) can alleviate the toxic effects of Cr(VI) by functioning as an antioxidant and/or by chelating Cr(VI) into biologically inert complexes, but the underlying mechanism remains unknown. Here, we evaluated whether Se can ameliorate ileum damage and cecal microbial disturbances induce...
Source: Biological Trace Element Research - January 15, 2022 Category: Biology Authors: Yanbing Zhao Huan Zhang Dezheng Hao Jinglu Wang Ding Zhang Zilong Sun Ci Liu Source Type: research

Metals in Wild and Cultured Dicentrarchus labrax (Linnaeus, 1758) from Fish Markets in Sinop: Consumer's Health Risk Assessment
Biol Trace Elem Res. 2022 Jan 15. doi: 10.1007/s12011-021-03064-8. Online ahead of print.ABSTRACTConcentrations of Cd, Hg, Pb, As, Al, Cu, Fe, and Zn were determined in the muscles of wild and farmed European seabass in Sinop markets between September and December in 2020, using inductively coupled plasma mass spectrometry after microwave digestion. In the study, iron (Fe), zinc (Zn), aluminum (Al), and copper (Cu) were found higher than the other metals both in wild and cultured Dicentrarchus labrax. These are essential elements, but excess amounts act as a poison. Arsenic (As) concentration was higher than cadmium (Cd), ...
Source: Biological Trace Element Research - January 15, 2022 Category: Biology Authors: Levent Bat Fatih Şahin Md Simul Bhuyan Elif Arici Ay şah Öztekin Source Type: research

An Adequate Supply of Bis(ethylmaltolato)oxidovanadium(IV) Remarkably Reversed the Pathological Hallmarks of Alzheimer's Disease in Triple-Transgenic Middle-Aged Mice
Biol Trace Elem Res. 2022 Jan 15. doi: 10.1007/s12011-021-02938-1. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a complex and progressive neurodegenerative disease with impaired synapse, imbalanced mineral metabolism, protein mis-folding and aggregation. Bis(ethylmaltolato)oxidovanadium(IV) (BEOV), an organic bioactive vanadium compound with low toxicity and high bioavailability, has been studied as therapeutic agent against tuberculosis and diabetes. However, its neuroprotective effects have rarely been reported. Therefore, in this study, the potential application of BEOV in intervening AD cognitive dysfuncti...
Source: Biological Trace Element Research - January 15, 2022 Category: Biology Authors: Zhijun He Lin Zheng Xu Zhao Xiaoqian Li Hua Xue Qionghui Zhao Bingyu Ren Nan Li Jiazuan Ni Yan Zhang Qiong Liu Source Type: research

Assessment of Serum Elements Concentration and Polycystic Ovary Syndrome (PCOS): Systematic Review and Meta-analysis
Biol Trace Elem Res. 2022 Jan 14. doi: 10.1007/s12011-021-03058-6. Online ahead of print.ABSTRACTChange in the levels of trace elements has been linked with PCOS pathogenesis by various studies, whereas some had reported no such association. Therefore, in order to evaluate association of eleven trace element (Cu, Zn, Cr, Cd, Se, Mn, Fe, Mg, Co, Ni and Pb) serum concentration with PCOS pathogenesis, current systematic review and meta-analysis has been carried out. Literature search was conducted using PubMed, Central Cochrane Library, Google Scholar and Science Direct databases with appropriate keywords. Studies published u...
Source: Biological Trace Element Research - January 14, 2022 Category: Biology Authors: Priya Sharma Vartika Gupta Kush Kumar Preeti Khetarpal Source Type: research

Protective Effects of Zinc on Salmonella Invasion, Intestinal Morphology and Immune Response of Young Pigeons Infected with Salmonella enterica Serovar Typhimurium
Biol Trace Elem Res. 2022 Jan 14. doi: 10.1007/s12011-021-03057-7. Online ahead of print.ABSTRACTThe study aimed to determine the effects of orally supplemental zinc on body weight, Salmonella invasion, serum IgA, intestinal histomorphology, and immune response of Salmonella enterica serovar Typhimurium (S. typhimurium)-challenged young pigeons. A total of 72 healthy White King pigeons (25 days old) with similar weight were randomly assigned to 3 treatments with six replicate cages. The 3 treatments were unchallenged, S. typhimurium-challenged, and S. typhimurium-challenged orally supplemented with 1 mg zinc per bird. Salm...
Source: Biological Trace Element Research - January 14, 2022 Category: Biology Authors: Zheng Wang Xing Li Shaohua Du Xiaoshan Sun Jianguo Huang Yuxin Shao Source Type: research

A Comparison of the Beneficial Effects of Inorganic, Organic, and Elemental Nano-selenium on Nile Tilapia: Growth, Immunity, Oxidative Status, Gut Morphology, and Immune Gene Expression
This study investigates the effects of different sources of selenium (inorganic (SSE), organic (OSE), and elemental nano-selenium (NSE)) on the performance of Nile tilapia (Oreochromis niloticus). In total, 204 Nile tilapia fingerlings were randomly divided into 4 equal groups fed 1 of 4 diets: a control (adding no selenium) and 3 diets as selenium sources (1 mg/kg diet), After a 65-day feeding trial, the growth performance parameters of Nile tilapia were significantly enhanced by dietary selenium supplementation (P
Source: Biological Trace Element Research - January 14, 2022 Category: Biology Authors: Sameh Ghaniem Eldsokey Nassef Amr I Zaineldin Abdulnasser Bakr Sayed Hegazi Source Type: research

Correlation of Serum Selenium in Asthma Patients with Severity of the Disorder
Biol Trace Elem Res. 2022 Jan 13. doi: 10.1007/s12011-022-03096-8. Online ahead of print.ABSTRACTAsthma is characterized by reversible airway obstruction, increased bronchial hyper-responsiveness and chronic inflammation, as well as higher levels of oxidative stress mainly due to decreased antioxidant defenses. Our primary aim was to investigate the correlation of serum selenium (Se) levels with the severity of asthma across gender, age, family history, and prevalence from childhood. Selenium levels in blood samples in 103 asthmatic patients and 103 healthy individuals were evaluated. The obtained data indicated that the m...
Source: Biological Trace Element Research - January 14, 2022 Category: Biology Authors: Nidhi Girdhar Heena Kansal Kranti Garg Siddharth Sharma K Sandeep Prabhu Vishal Chopra Alexey A Tinkov Anatoly V Skalny N Tejo Prakash Source Type: research

Correction to: Linarin Protects against Cadmium-Induced Osteoporosis Via Reducing Oxidative Stress and Infammation and Altering RANK/RANKL/OPG Pathway
Biol Trace Elem Res. 2022 Jan 14. doi: 10.1007/s12011-022-03108-7. Online ahead of print.NO ABSTRACTPMID:35029781 | DOI:10.1007/s12011-022-03108-7 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 14, 2022 Category: Biology Authors: Yating Yang Ruining Cheng Jingyun Liu Jing Fang Xiaojing Wang Yingxue Cui Pan Zhang Bin Du Source Type: research

Toxicity of Nanocomplexes Containing Gadolinium Orthovanadate Nanoparticles and Cholesterol
Biol Trace Elem Res. 2022 Jan 13. doi: 10.1007/s12011-021-03019-z. Online ahead of print.ABSTRACTPrevious studies have shown the ability of nanocomplexes (NCs), which consist of nanoparticles (NPs) of orthovanadates of rare earth metals (GdYVO4:Eu3+) and cholesterol, to inhibit the growth of Ehrlich's ascites carcinoma (EAC). However, the biosafety of these NCs remains unclear. Our objective was to investigate the acute and subchronic toxicity of NCs. NCs were administered to BALB/c mice in NPs concentration of 5.9; 29.5; 59.1; and 118.2 mg/kg. Acute toxicity was induced by a single administration of NCs, subchronic-by rep...
Source: Biological Trace Element Research - January 13, 2022 Category: Biology Authors: Anatoliy Goltsev Natalia Babenko Yuliia Gaevska Mykola Bondarovych Tetiana Dubrava Lyudmila Ostankova Nataliia Volkova Vladimir Klochkov Source Type: research

Impact of Chronic Sodium Fluoride Toxicity on Antioxidant Capacity, Biochemical Parameters, and Histomorphology in Cardiac, Hepatic, and Renal Tissues of Wistar Rats
Biol Trace Elem Res. 2022 Jan 12. doi: 10.1007/s12011-022-03113-w. Online ahead of print.ABSTRACTThe study was designed to determine the fluoride distribution after its oral exposure in drinking water and its associated impact on biochemical, antioxidant markers and histology in the liver, kidney, and heart of male Wistar rats. On 100 ppm exposure, the highest accretion of fluoride occurred in the liver followed by the kidney and heart. Fluoride exposure significantly (p˂0.05) increased the plasma levels of dehydrogenase, aminotransferases, kidney injury molecule-1 (KIM-1), and other plasma renal biomarkers but decreased ...
Source: Biological Trace Element Research - January 13, 2022 Category: Biology Authors: Priyanka Sharma Pawan Kumar Verma Shilpa Sood Maninder Singh Deepika Verma Source Type: research