Propolis and Its Combination with Boric Acid Protect Against Ischemia/Reperfusion-Induced Acute Kidney Injury by Inhibiting Oxidative Stress, Inflammation, DNA Damage, and Apoptosis in Rats.
In conclusion, propolis alone and its combination with boric acid could be developed as therapeutic agents against serious renal I/R injuries. PMID: 30783919 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - February 19, 2019 Category: Biology Authors: Geyikoglu F, Koc K, Colak S, Erol HS, Cerig S, Yardimci BK, Cakmak O, Dortbudak MB, Eser G, Aysin F, Ozek NS, Yildirim S Tags: Biol Trace Elem Res Source Type: research

The Toxicological Analysis of Ni and Cr in Prescription Food for Special Medical Purposes and Modified Milk Products for Babies in Infancy Available in Pharmacies in Poland.
Abstract Prescription food for special medical purposes (FSMPs) and modified milk products (MMPs) for babies in the infancy period available in pharmacies are increasingly frequently used for newborns and infants-especially in cases where allergies and food-borne diseases are diagnosed. However, there is a lack of scientific study around the safety assessment of the elemental impurities in these products. Importantly, the allergen Ni and the problematic metal Cr are little considered. Hence, the aim of this article was the toxicological analysis of Ni and Cr impurities in prescription FSMPs (n = 6) a...
Source: Biological Trace Element Research - February 19, 2019 Category: Biology Authors: Jurowski K, Krośniak M, Fołta M, Tatar B, Cole M, Piekoszewski W Tags: Biol Trace Elem Res Source Type: research

Effect of the Zn Supplementation on Immuno-Modulatory Activities of Bovine Lactoferrin in the Murine Splenocytes and RAW264.7 Macrophages.
Abstract Lactoferrin (LF) has important bio-functions including immuno-modulation, while essential trace metals may interact with LF and thereby induce property especially bio-activity changes. Bovine LF was thus supplemented with Zn2+ at 0.16, 0.32, and 0.64 mg/g LF to yield 10%, 20%, and 40% Zn-saturation, respectively. Afterwards, bovine LF and the Zn-supplemented LF products at 10-40-μg/mL doses were compared for their immuno-modulatory activities in two immune cells (murine splenocytes and RAW264.7 macrophages), using the stimulation index of the splenocytes, T lymphocyte subpopulations, macrophage ph...
Source: Biological Trace Element Research - February 19, 2019 Category: Biology Authors: Zhao HJ, Zhao XH Tags: Biol Trace Elem Res Source Type: research

Comparative Response of Cardiomyocyte ZIPs and ZnTs to Extracellular Zinc and TPEN.
Abstract Intracellular zinc concentrations are tightly regulated by the coordinated regulation of ZIPs and ZnTs. Very little is known about the regulation of these transporters in cardiomyocytes, in response to extracellular zinc. Adult rat cardiomyocytes express ZnTs 1, 2, 5, and 9, in addition to ZIPs 1, 2, 3, 6, 7, 9, 10, 11, 13, and 14. We have determined the intracellular free zinc levels using Zinpyr-1 fluorescence and studied response of ZIP and ZnT mRNA by real-time PCR to the changes in extracellular zinc and TPEN in adult rat ventricular myocytes. TPEN downregulated ZnT1, ZnT2, and ZIP11 mRNAs but upregu...
Source: Biological Trace Element Research - February 18, 2019 Category: Biology Authors: Thokala S, Bodiga VL, Kudle MR, Bodiga S Tags: Biol Trace Elem Res Source Type: research

The Alterations of Copper and Zinc Homeostasis in Acute Appendicitis and the Clinical Significance.
This study was to investigate the clinical significance of Cu and Zn homeostasis alterations in acute appendicitis (AA). One hundred twenty-two AA patients and 102 healthy controls were enrolled in this study. Of which, 85 patients' appendixes were collected after appendectomy. Another six appendixes from colon cancer patients were collected as tissue controls. The contents of Cu and Zn in serum or appendix were detected, and the Cu to Zn ratio (CZr) was calculated. The concentrations of serum ceruloplasmin (CP), Cu/Zn superoxide dismutase (SOD1), interleukin-6 (IL-6), and interleukin-22 in serum were measured, as well as ...
Source: Biological Trace Element Research - February 15, 2019 Category: Biology Authors: Lin W, Han W, Wen K, Huang S, Tang Y, Lin Z, Han M Tags: Biol Trace Elem Res Source Type: research

The Role of Zinc in Poultry Breeder and Hen Nutrition: an Update.
Abstract Zinc (Zn) is an essential trace mineral in breeder hen diets and functions in diverse physiological processes, including reproduction, immunity, antioxidant ability, and epigenetic processes. In this paper, five main aspects of Zn nutrition in poultry breeder birds and hens, including semen quality, molting, egg production and egg quality, hatchability and embryonic development, and offspring performance, are reviewed. Zn deficiency in poultry breeder birds led to lower semen quality (reducing around 10% sperm motility) and egg production (lowering 3-10 g/day/bird egg mass) as well as poor offspring ...
Source: Biological Trace Element Research - February 14, 2019 Category: Biology Authors: Huang L, Li X, Wang W, Yang L, Zhu Y Tags: Biol Trace Elem Res Source Type: research

Dose-Dependent Absorption Profile of Different Magnesium Compounds.
Abstract Magnesium, one of the basic elements for the human body, is necessary for many physiological functions. Magnesium deficiency is widely observed as a result of the reduced nutrient content of foods, over-cooking, diseases, drugs, alcohol, and caffeine consumption. Taking a dietary supplement is necessary magnesium deficiency. It has been demonstrated that absorption of organic magnesium compounds is better than absorption of inorganic compounds. The aim of this study is to investigate transitions to tissues of different organic magnesium compounds in different doses and whether there is a difference in the...
Source: Biological Trace Element Research - February 13, 2019 Category: Biology Authors: Ates M, Kizildag S, Yuksel O, Hosgorler F, Yuce Z, Guvendi G, Kandis S, Karakilic A, Koc B, Uysal N Tags: Biol Trace Elem Res Source Type: research

Se Regulates the Contractile Ability of Uterine Smooth Musclevia Selenoprotein N, Selenoprotein T, and Selenoprotein Win Mice.
In this study, genes related to SelN, SelT, and SelW expression in uterine smooth muscle cells were investigated. The results showed that the Se concentration had an effect on the expression of SelN, SelT, and SelW in uterine smooth muscle cells. Se influences the release of Ca2+ through SelN, SelT, and SelW, which changes the expression of MLCK and then affects uterine smooth muscle contractions. The three selenoproteins SelN, SelT, and SelW play a very important role in uterine smooth muscle contractions, and the absence of any of these proteins affects the contractility of the uterus. PMID: 30756291 [PubMed - as su...
Source: Biological Trace Element Research - February 12, 2019 Category: Biology Authors: Wang FH, Peng X, Chen Y, Wang Y, Yang M, Guo MY Tags: Biol Trace Elem Res Source Type: research

The Effect of Multispecies Probiotic Supplementation on Iron Status in Rats.
Abstract A range of interactions between gut microbiota and iron (Fe) metabolism is described. Oral probiotics ameliorate host's iron status. However, this has been proven for single-strain probiotic supplements. Dose-dependence of beneficial probiotic supplementation effect on iron turnover remains unexplored. Our study aimed to investigate the effects of oral multispecies probiotic supplementation in two doses on iron status in rats. Thirty rats were randomized into three groups receiving multispecies probiotic supplement at a daily dose of 2.5 × 109 CFU (PA group, n = 10) an...
Source: Biological Trace Element Research - February 12, 2019 Category: Biology Authors: Skrypnik K, Bogdański P, Schmidt M, Suliburska J Tags: Biol Trace Elem Res Source Type: research

The Effects of Low Selenium on DNA Methylation in the Tissues of Chickens.
Abstract DNA methylation is involved in epigenetic mechanisms associated with gene suppression, and its abnormalities lead to gene instability and disease development. As an essential trace element in humans and animals, selenium (Se) is also associated with abnormal changes in DNA methylation. However, the effect of low Se on DNA methylation in avian tissues has not been reported. In the current study, chickens were fed a low-Se diet (0.033 mg Se/kg) or supplemented with 0.15 mg Se/kg as selenite for up to 55 days. DNA methylation levels were examined by high-performance liquid chromatogr...
Source: Biological Trace Element Research - February 8, 2019 Category: Biology Authors: Zhang Q, Zheng S, Wang S, Jiang Z, Xu S Tags: Biol Trace Elem Res Source Type: research

Cadmium in Groundwater Consumed in the Rural Areas of Gonabad and Bajestan, Iran: Occurrence and Health Risk Assessment.
This study was performed to estimate the concentration of cadmium and the health risk to human by cadmium through the ingestion of groundwater in 39 rural areas of Gonabad and Bajestan, eastern Iran. The mean cadmium concentrations in groundwater in the studied rural areas of Gonabad and Bajestan ranged from 0.087 to 14.32 μg/L and from 0.417 to 18.36 μg/L, respectively. Health risk quotient for cadmium contamination for 16 and 38% of children and infants in rural areas of Gonabad and Bajestan, respectively, was more than 1 which causes non-carcinogenic risk to the local population. The carcinogenic risk of...
Source: Biological Trace Element Research - February 8, 2019 Category: Biology Authors: Qasemi M, Shams M, Sajjadi SA, Farhang M, Erfanpoor S, Yousefi M, Zarei A, Afsharnia M Tags: Biol Trace Elem Res Source Type: research

Genomic Characterization of the Zinc Transcriptional Regulatory Element Reveals Potential Functional Roles of ZNF658.
Abstract The zinc transcriptional regulatory element (ZTRE) is a newly reported binding motif for human zinc finger protein ZNF658, which alters gene expression in response to cellular zinc. The ZTRE has two nucleotide components-the palindromic flanking pairs and the bridging "N" bases between these flanks that range in number from 0 to 100. There are 12 pairs of ZTRE flanks (designated A-L). Three thousand five hundred twenty-five genes contain one or more ZTREs - 1000 to + 200 bp from their transcriptional start site (TSS). ZTRE-E is observed at a greater frequency, and ZTRE contain...
Source: Biological Trace Element Research - February 7, 2019 Category: Biology Authors: Francis M, Cheng H, Ma P, Grider A Tags: Biol Trace Elem Res Source Type: research

Dietary Intake of Cadmium, Chromium, Copper, Nickel, and Lead through the Consumption of Meat, Liver, and Kidney and Assessment of Human Health Risk in Birjand, Southeast of Iran.
This study aimed to evaluate the mean concentration of cadmium (Cd), chromium (Cr), copper (Cu), nickel (Ni), and lead (Pb) in the meat and offal of cow and sheep. Also, the estimated daily intake (EDI) and health risk of these metals were calculated. Analysis of metals was undertaken by the use of an inductively coupled plasma-optic emission spectroscopy (ICP-OES). All samples were contaminated with all metals. Principal component analysis (PCA) showed a clear differentiation of cow and sheep in both the kidney and liver samples. In the liver and kidney, level of Cd, Cu, and Pb were positively correlated. The highest targ...
Source: Biological Trace Element Research - February 6, 2019 Category: Biology Authors: Zeinali T, Salmani F, Naseri K Tags: Biol Trace Elem Res Source Type: research

Selenium Levels in Community Dwellers with Type 2 Diabetes Mellitus.
This study aimed at, through measurements of serum selenoprotein P (SelP), glutathione peroxidase (GPx3), and Se content in serum and hair, evaluating Se levels in community dwellers with type 2 diabetes mellitus (T2DM). A total of 336 subjects, including 176 T2DM patients (65.5 ± 8.7 years old) and 160 healthy residents (63.7 ± 9.8 years old, as controls), were recruited in this cross-sectional community-based study performed in Suzhou. Samples of fasting venous blood and hair were collected for measurements of Se levels, glycometabolism, and biochemistry parameters...
Source: Biological Trace Element Research - February 6, 2019 Category: Biology Authors: Zhang Q, Li W, Wang J, Hu B, Yun H, Guo R, Wang L Tags: Biol Trace Elem Res Source Type: research

Parenteral Zinc Supplementation Increases Pregnancy Rates in Beef Cows.
In conclusion, the results obtained in the present study determined that parenteral Zn supplementation at the beginning of the FTAI protocol increased preovulatory follicle size, plasma P4 concentration, and pregnancy rates in beef cows. PMID: 30723881 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - February 5, 2019 Category: Biology Authors: Anchordoquy JM, Anchordoquy JP, Galarza EM, Farnetano NA, Giuliodori MJ, Nikoloff N, Fazzio LE, Furnus CC Tags: Biol Trace Elem Res Source Type: research

High-Protein Diet Ameliorates Arsenic-Induced Oxidative Stress and Antagonizes Uterine Apoptosis in Rats.
In conclusion, arsenic mediates its reproductive toxicity, at least in part, by upsetting the uterine ROS homeostasis and redox regulation. Pea proteins and casein-supplemented HPD can counteract the arsenic effects and maintain the reproductive functions. PMID: 30723882 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - February 5, 2019 Category: Biology Authors: Biswas P, Mukhopadhyay A, Kabir SN, Mukhopadhyay PK Tags: Biol Trace Elem Res Source Type: research

Cadmium Exposure and Blood Telomere Length in Female University Students in Japan.
Abstract Cadmium is a toxic metal found ubiquitously throughout the world. Our study evaluated whether cadmium exposure was associated with telomere length in 73 female university students. Determination of telomere length was performed by quantitative polymerase chain reaction using DNA in blood. Urinary cadmium concentration was measured by inductively coupled plasma mass spectrometry. The students' physiological attributes and lifestyle were surveyed by means of a self-administered questionnaire. The geometric mean of urinary cadmium concentration was 0.312 μg/g creatinine, which was lower than the leve...
Source: Biological Trace Element Research - February 5, 2019 Category: Biology Authors: Mizuno Y, Konishi S, Imai H, Fujimori E, Kojima N, Yoshinaga J Tags: Biol Trace Elem Res Source Type: research

Is the Cooking Salt Safe in China? Assessment of Chemical Contaminants in Cooking Salt.
Abstract Global environmental pollution is becoming more serious, and most dietary salts come from nature. We postulated that chemical pollutants could affect the quality of salt. Forty-five different types of salt were collected from supermarkets, convenience stores, and online retailers in Shanghai, 2015. These comprised more than 90% of all cooking salts consumed in Shanghai, China. We measured and analyzed heavy metal elements, fluoride, potassium ferrocyanide, and 16 phthalate plasticizers. Lead was detected in only two types of salt at concentrations recorded of 0.047 mg/kg and 0.077 mg/kg. The con...
Source: Biological Trace Element Research - February 5, 2019 Category: Biology Authors: Wang Z, Zhou J, Jia X Tags: Biol Trace Elem Res Source Type: research

The Possibilities of Using Chromium Salts as an Agent Supporting Treatment of Polycystic Ovary Syndrome.
Abstract The polycystic ovary syndrome (PCOS) is the most frequent endocrinopathy in women in reproductive age with the so far undetermined causes of development. In the etiopathogenesis of PCOS, the role of insulin resistance is emphasised, which was an indication for the attempts at using chromium III salts (Cr) in augmenting pharmacotherapy applied in patients. The analysis of the usefulness and efficacy of this approach was the direct goal of this thesis. Animal tests confirmed the efficacy of chromium in maintaining the appropriate level of glycaemia and insulinaemia, normalisation of plasma concentrations of...
Source: Biological Trace Element Research - February 4, 2019 Category: Biology Authors: Piotrowska A, Pilch W, Czerwińska-Ledwig O, Zuziak R, Siwek A, Wolak M, Nowak G Tags: Biol Trace Elem Res Source Type: research

Glutathione Might Attenuate Cadmium-Induced Liver Oxidative Stress and Hepatic Stellate Cell Activation.
In this study, 24 rats were divided randomly into four experimental groups: control, GSH-treated, Cd-treated, and Cd + GSH-treated. After 4 weeks, the liver injury index, HSC-specific activation markers, oxidative stress-related antioxidants, and enzyme activities and signals were measured. Cd uptake and the generation of reactive oxygen species (ROS) in hepatocytes were detected by mass cytometry and fluorescence microscopy, respectively. Levels of aspartate aminotransferase, xanthine oxidase, γ-glutamyl transpeptidase, and α-smooth muscle actin (αSMA) were significantly increased in Cd-treated rats...
Source: Biological Trace Element Research - February 4, 2019 Category: Biology Authors: Ren L, Qi K, Zhang L, Bai Z, Ren C, Xu X, Zhang Z, Li X Tags: Biol Trace Elem Res Source Type: research

Association Between Trace Element Status and Depression in HTLV-1-Infected Patients: a Retrospective Cohort Study.
Abstract Depression and Anxiety are two important public health problems that are known to be associated with viral infections. The association between the intake of nutrients such as zinc and copper with symptoms of depression has been studied previously. The aim of the current study was to investigate the association between depression with human T cell lymphotropic virus type 1 (HTLV-1) infection and serum content of zinc and copper in a large Iranian population cohort. The study population consisted of 279 HTLV-1-positive patients who were identified after recruitment as part of a large cohort study: the Mashh...
Source: Biological Trace Element Research - February 4, 2019 Category: Biology Authors: Darroudi S, Abolbashari S, Ahangari N, Tayefi M, Khashyarmanesh Z, Zamani P, Haghighi HM, Mohammadpour AH, Tavalaei S, Esmaily H, Ferns GA, Meshkat Z, Tayefi B, Ghayour-Mobarhan M Tags: Biol Trace Elem Res Source Type: research

In Vivo Effect of Bis(Maltolato)Zinc(II) Complex on Akt Phosphorylation in Adipose Tissues of Mice.
In this study, we evaluated the effect of bis(maltolato)zinc(II) complex [Zn(mal)2] on male ICR mice (6-week-old) that received intraperitoneal (i.p.) injection of [Zn(mal)2]. The liver, skeletal muscle, and adipose tissues were collected from mice under anesthesia with isoflurane 40 or 90 min after i.p. injection. The [Zn(mal)2]-treatment did not affect Akt phosphorylation in the liver or skeletal muscle. In contrast, in adipose tissues, [Zn(mal)2]-treatment showed increased Akt phosphorylation at 40 min and 90 min after injection (p 
Source: Biological Trace Element Research - January 31, 2019 Category: Biology Authors: Naito Y, Yamamoto H, Yoshikawa Y, Yasui H Tags: Biol Trace Elem Res Source Type: research

Editorial.
Abstract PMID: 30706356 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 31, 2019 Category: Biology Authors: Nielsen FH Tags: Biol Trace Elem Res Source Type: research

The Protective Role of Selenium Against AFB1-Induced Liver Apoptosis by Death Receptor Pathway in Broilers.
In conclusion, Se could relieve AFB1-induced apoptosis by the molecular regulation of death receptors pathway in the liver of broilers. The outcomes from the present study may lead to a better understanding of the nature of selenium's essentiality and its protective roles against AFB1. PMID: 30697680 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - January 29, 2019 Category: Biology Authors: Wu B, Mughal MJ, Fang J, Peng X Tags: Biol Trace Elem Res Source Type: research

Pharmacokinetics of Selenium in Healthy Piglets After Different Routes of Administration: Application of Pharmacokinetic Data to the Risk Assessment of Selenium.
Abstract Selenium (Se) is a trace element in the environment. Although it is a necessary trace element for human and animal health, excessive Se can also pollute the environment and show toxic effects on humans and animals. Since the safe dose range of Se is narrow, it is important to study the pharmacokinetics of Se in order to make better use of the biological effects of Se. In the present study, we investigated the pharmacokinetic process of sodium selenate in healthy piglet plasma after either intramuscular injection or oral administrations, and examined dynamic changes of antioxidant system in healthy piglets...
Source: Biological Trace Element Research - January 26, 2019 Category: Biology Authors: Xing H, Zheng S, Zhang Z, Zhu F, Xue H, Xu S Tags: Biol Trace Elem Res Source Type: research

Safety Assessment of the Trace Element Impurities Ni and Cr in Pharmaceutical Herbal Products for Teething from Polish Pharmacies.
Abstract Control of elemental impurities (EIs) in pharmaceutical herbal products is currently important but not a very popular topic in modern toxicological analysis. The occurrence and concentration of EIs in the pharmaceutical herbal products should be controlled and meet the standards of directive International Conference on Harmonisation's Q3D Guideline on Elemental Impurities. An interesting area of interest is measuring EIs including toxic and allergic metals in pharmaceutical herbal products for teething. The aim of this article was determination of Ni and Cr impurities in pharmaceutical herbal products for...
Source: Biological Trace Element Research - January 25, 2019 Category: Biology Authors: Jurowski K, Krośniak M, Fołta M, Tatar B, Cole M, Piekoszewski W Tags: Biol Trace Elem Res Source Type: research

Protective Effects of Salidroside on Lead Acetate-induced Oxidative Stress and Hepatotoxicity in Sprague-Dawley Rats.
In this study, we established an animal model to evaluate the protective effects of SDS on chronic lead exposure induced oxidative stress and hepatotoxicity. Forty healthy Sprague-Dawley (SD) rats were assigned to control group (control, animals were provided with distilled water, n = 10); lead acetate-exposed group (PbAc, animals received lead acetate solution of 500 ppm for 60 days, n = 10); low dosage of SDS-treated group (PbAc-SDS-L, lead acetate exposed animals were given intragastric SDS 150 mg/kg body weight for 60 days, n = 10); and high dosage of SDS-tr...
Source: Biological Trace Element Research - January 21, 2019 Category: Biology Authors: Chen C, Lin B, Qi S, He J, Zheng H Tags: Biol Trace Elem Res Source Type: research

Decreased Expression of CHST-12, CHST-13, and UST in the Proximal Interphalangeal Joint Cartilage of School-Age Children with Kashin-Beck Disease: an Endemic Osteoarthritis in China Caused by Selenium Deficiency.
The objective of this study is to investigate changes in the expression of enzymes involved in chondroitin sulfate (CS) sulfation in distal articular surface of proximal interphalangeal joint isolated from school-age children patients with Kashin-Beck disease (KBD), using normal children as controls. Articular cartilage samples were collected from four normal and four KBD children (7-12 years old), and these children were assigned to control and KBD groups. Hematoxylin and eosin (H&E), toluidine blue (TB), and immunohistochemical (IHC) stainings were utilized to evaluate changes in joint pathology and expression o...
Source: Biological Trace Element Research - January 19, 2019 Category: Biology Authors: Guo Y, Zhou Y, Yan S, Qu C, Wang L, Guo X, Han J Tags: Biol Trace Elem Res Source Type: research

Evaluation of Cadmium Levels in Dental Calculus of Male Oral SCC Patients with Betel-Quid Chewing in Hunan Province of China.
This study included 85 male oral squamous cell carcinoma (SCC) cases with betel-quid chewing and smoking as observation subjects (group A) and 67 healthy people with smoking but without betel-quid chewing as control subjects (group B) in Hunan province of Mainland China. Cd levels in calcified dental calculus samples from all participants were measured by inductively coupled plasma mass spectrometry (ICP-MS). The results of this study indicated that cadmium levels in dental calculus were significantly higher in male oral SCC patients with betel-quid chewing and smoking than that in healthy individuals without habit of bete...
Source: Biological Trace Element Research - January 19, 2019 Category: Biology Authors: Zhang B, Tan X, He X, Yang H, Wang Y, Zhang K Tags: Biol Trace Elem Res Source Type: research

Trace Elements Homeostatic Imbalance in Psoriasis: a Meta-Analysis.
Abstract Studies point out that trace elements take vital roles in immunological and inflammatory reactions, such as psoriasis, while the conclusions are controversial. The purpose of this study was to analyze the existing literatures and explore the relationship between the risk of psoriasis and four trace elements zinc (Zn), copper (Cu), iron (Fe), and selenium (Se). We identified 42 studies through the databases PubMed, Embase, Cochrane Library, Google Scholar, and Web of knowledge. After the meta-analysis, the serum zinc, iron, and selenium levels showed no remarkable difference between psoriasis and controls....
Source: Biological Trace Element Research - January 15, 2019 Category: Biology Authors: Chen W, Zhou X, Zhu W Tags: Biol Trace Elem Res Source Type: research

Comparison of Copper Concentration Between Rejected Renal Grafts and Cancerous Kidneys.
ska E Abstract In the body, disorders in the composition and concentration of trace elements, including copper, can lead to the development of various alterations that may result in incorrect functioning of the kidneys. Data on the concentrations of copper in human kidneys are discussed; however, little is known about the concentration of trace elements within rejected renal grafts and kidneys with tumor lesions. The aim of our study was to compare the copper concentration between cancerous kidneys and rejected renal grafts with the division on renal cortex and renal medulla. Material consisted of kidneys from pat...
Source: Biological Trace Element Research - January 15, 2019 Category: Biology Authors: Wilk A, Wiszniewska B, Rzuchowska A, Romanowski M, Różański J, Słojewski M, Ciechanowski K, Kalisińska E Tags: Biol Trace Elem Res Source Type: research

Effects of Selenium Supplementation on Metabolic Status in Patients Undergoing for Coronary Artery Bypass Grafting (CABG) Surgery: a Randomized, Double-Blind, Placebo-Controlled Trial.
This study was carried out to evaluate the effects of selenium supplementation on glycemic control, lipid profiles, and biomarkers of inflammation and oxidative stress in patients undergoing for coronary artery bypass grafting (CABG) surgery. This randomized, double-blind, placebo-controlled trial was performed among 33 patients undergoing for CABG surgery, aged 40-85 years old. Subjects were randomly allocated into two groups to intake either 200 μg/day selenium supplements as selenium yeast (n = 17) or placebo (n = 16) for 4 weeks. Glycemic control, lipid profiles, and biomar...
Source: Biological Trace Element Research - January 14, 2019 Category: Biology Authors: Kamali A, Amirani E, Asemi Z Tags: Biol Trace Elem Res Source Type: research

Assessment of Gender Effects and Reference Values of Mane Hair Trace Element Content in English Thoroughbred Horses (North Caucasus, Russia) Using ICP-DRC-MS.
The objective of the present study was assessment of gender differences in hair trace element content in English Thoroughbred horses (North Caucasus, Russia) using ICP-DRC-MS and calculation of the reference values. Trace element content in mane hair of 190 stallions and 94 mares (3-7 years old) bred in North Caucasus (Russia) was assessed using inductively coupled plasma mass spectrometry. Mane hair Co, Cr, Mn, Li, Si, and Sr levels in mares exceeded those in stallions by 77%, 63%, 64%, 42%, 39%, and 64%, respectively. Hair Fe and Si content was nearly twofold higher in female horses as compared to the males. Only ha...
Source: Biological Trace Element Research - January 11, 2019 Category: Biology Authors: Kalashnikov VV, Zajcev AM, Atroshchenko MM, Miroshnikov SA, Zavyalov OA, Frolov AN, Skalny AV Tags: Biol Trace Elem Res Source Type: research

Zinc Deficiency and Arsenic Exposure Can Act Both Independently or Cooperatively to Affect Zinc Status, Oxidative Stress, and Inflammatory Response.
In this study, we tested the effect of arsenic exposure at environmentally relevant doses in combination with a physiologically relevant level of zinc deficiency (marginal zinc deficiency) on zinc status, oxidative damage, and inflammation. In cell culture, zinc-deficient THP-1 monocytes co-exposed with arsenic resulted in further reduction in intracellular zinc, as well as further increase in oxidative stress and inflammatory markers. In an animal study, zinc-deficient mice had further decrease in zinc status when co-exposed to arsenic. Zinc deficiency, but not arsenic exposure, resulted in an increase in baseline tr...
Source: Biological Trace Element Research - January 11, 2019 Category: Biology Authors: Wong CP, Dashner-Titus EJ, Alvarez SC, Chase TT, Hudson LG, Ho E Tags: Biol Trace Elem Res Source Type: research

Effects of Fungal Polysaccharide on Oxidative Damage and TLR4 Pathway to the Central Immune Organs in Cadmium Intoxication in Chickens.
Abstract Cadmium (Cd) can cause animal organism damage, but there have been few studies on the damage of cadmium to the immune organs of birds. Most fungal polysaccharide has antioxidant and immunomodulatory effects. The experimental study investigated the effects of fungal polysaccharide (Agaricus blazei Murill polysaccharide and Ganoderma luciduccharide) on the oxidative damage of central immune organs (thymus and bursa of Fabricius) and on the Toll-like receptor 4 (TLR4) pathway in cadmium-poisoned chickens. The results showed that Agaricus blazei polysaccharide and Ganoderma lucidum polysaccharide can reduce c...
Source: Biological Trace Element Research - January 10, 2019 Category: Biology Authors: Li R, Zhang L, Tang Z, Li T, Li G, Zhang R, Ge M Tags: Biol Trace Elem Res Source Type: research

A Review of Iodine Status of Women of Reproductive Age in the USA.
The objective of this scoping review was to summarize the studies that assessed iodine status of women of reproductive age in the USA. A systematic review of literature using the PRISMA Extension for Scoping Reviews (PRISMA-ScR) statement was conducted. PubMed, Medline, CINAHL, EMBASE, EBSCOHost, Cochrane, ERIC, Google Scholar, and Web of Science databases were searched, 1652 records were identified. One thousand six hundred forty-one records that did not satisfy the inclusion/exclusion criteria and quality review were excluded, and 11 peer-reviewed articles were determined to be eligible for this scoping review. Despite t...
Source: Biological Trace Element Research - January 7, 2019 Category: Biology Authors: Panth P, Guerin G, DiMarco NM Tags: Biol Trace Elem Res Source Type: research

Association Between Cortisol, Insulin Resistance and Zinc in Obesity: a Mini-Review.
Abstract Adipose tissue is considered an endocrine organ and its excess compromises the immune response and the metabolism of hormones and nutrients. Furthermore, visceral fat accumulation contributes to increased cortisol synthesis, which in turn induces metallothionein and Zip14 expression, which are proteins that contribute to reducing plasma zinc levels. Zinc plays a critical role in the secretion and signaling of insulin. Changes in the biochemical parameters of zinc, as observed in individuals who are obese, contribute to the manifestation of related disorders such as insulin resistance. Thus, the purpose of...
Source: Biological Trace Element Research - January 7, 2019 Category: Biology Authors: Morais JBS, Severo JS, Beserra JB, de Oiveira ARS, Cruz KJC, de Sousa Melo SR, do Nascimento GVR, de Macedo GFS, do Nascimento Marreiro D Tags: Biol Trace Elem Res Source Type: research

Cadmium and Lead Hazardous Impact Assessment of Pond Fish Species.
Abstract The current study aims to assess the concentration of cadmium (Cd) and lead (Pb) in five tissues of Cirrhinus mrigala, Labeo rohita, and Catla catla collected from fishponds of Jamshoro and Larkana, Sindh, Pakistan. Meanwhile, the levels of Cd and Pb in feeding materials, water, and sediments of fishponds of both areas were also studied. The daily intake and hazardous impact assessment of Cd and Pb by muscles of three fish species of fishponds of both areas were estimated. The concentration of Cd in tissues of C. mrigala and C. catla of Larkana were higher than that in tissues of same fish species of Jams...
Source: Biological Trace Element Research - January 5, 2019 Category: Biology Authors: Junejo SH, Baig JA, Kazi TG, Afridi HI Tags: Biol Trace Elem Res Source Type: research

Borax Alleviates Copper-Induced Renal Injury via Inhibiting the DNA Damage and Apoptosis in Rainbow Trout.
H, Atamanalp M Abstract The aim of this study was to determine the therapeutic potential of borax against copper in the kidney tissue of the rainbow trout fed with added borax (BX) (1.25, 2.5, and 5 mg/kg) and/or copper (Cu) (500,1000 mg/kg) contents. For this purpose, two treatment groups had designed, and glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) enzyme activities were determined. Besides, oxidative DNA damage (8-hydroxy-2'-deoxyguanosine, 8-OHdG), caspase-3, and malondialdehyde (MDA) levels were assessed in kidneys of all treatment groups. In molecular pathway, hsp7...
Source: Biological Trace Element Research - January 5, 2019 Category: Biology Authors: Alak G, Yeltekin AÇ, Uçar A, Parlak V, Türkez H, Atamanalp M Tags: Biol Trace Elem Res Source Type: research

Concentrations and Health Risk Assessment of Trace Elements in Cereals, Fruits, and Vegetables of Bangladesh.
This study was conducted to determine concentrations of five toxic trace elements (Cr, Ni, As, Cd, and Pb) in cereals, fruits, and vegetables of Bangladesh. The range of mass fractions (mg/kg) of Cr, Ni, As, Cd, and Pb in the foodstuffs was 0.090-2.5, 0.03-2.6, 0.13-1.7, 0.010-0.74, and 0.37-2.2, respectively. This study indicates that concentration of Cr, and Pb in fruits; As, Cd, and Pb in vegetables were higher than WHO/FAO maximum allowable concentration levels. The hazard index (HI) values for adults and children of the toxic elements in studied cereals, fruits and vegetables were higher than 1.0, suggesting non-carci...
Source: Biological Trace Element Research - January 5, 2019 Category: Biology Authors: Rahman M, Islam MA Tags: Biol Trace Elem Res Source Type: research

Copper and Zinc Nutritional Issues for Agricultural Animal Production.
Abstract Livestock have presented unique requirements and toxicity issues depending on the species for the various concentrations of Cu and Zn and their interactions with other nutrients especially Fe, Se, Mo, and S. Soil concentrations of these elements and their availability to crops influence the health of the crop and the amount found in vegetative tissues and seeds. Hence, many livestock issues are a result of the soils in the area where production is occurring (Loneragan et al. 1981). While water can provide minerals to animals, the amount consumed and availability are highly variable. Many discoveries about...
Source: Biological Trace Element Research - January 5, 2019 Category: Biology Authors: Hill GM, Shannon MC Tags: Biol Trace Elem Res Source Type: research

Mechanism Underlying the Protective Effect of Selenium on NO-Induced Oxidative Damage in Bovine Mammary Epithelial Cells.
Abstract This experiment was conducted to investigate the effects and mechanism of selenium (Se) on antioxidant and immune function of bovine mammary epithelial cells (BMEC) damaged by nitric oxide (NO). The third-generation BMEC was randomly divided into eight treatments with six replicates. The BMEC in the control group was cultured in the medium without Se and diethylenetriamine/NO (DETA/NO) for 30 h. For the DETA/NO group and Se protection group BMEC were exposed to different concentrations of Se (0, 10, 20, 50, 100, 150, and 200 nmol/L) for 24 h, followed by treatment with DETA/NO (1000 &m...
Source: Biological Trace Element Research - January 4, 2019 Category: Biology Authors: Guo Y, Guo X, Yan S, Zhang B, Shi B Tags: Biol Trace Elem Res Source Type: research

Use of 2-Hydrazinobenzothiazole-Modified Copolymer(s) as Potential Chelating Agent for Sensitive and Selective Determination of Low Levels of Mercury in Seafood by Ultrasound-Assisted Cloud-Point Extraction Combined with Spectrophotometry.
In this study, a new method was developed for the pre-concentration of trace mercury from seafood samples prior to analysis by spectrophotometry. The method is based on the complexation between 2-hydrazinobenzothiazole (2-HBT)-modified copolymer(s) and Hg(II) in the presence of an ionic surfactant, cetyltrimethylammonium bromide (CTAB), as sensitivity enhancer at pH 4.5 and the extraction of the complex into the surfactant-rich phase of polyethylene glycol tert-octylphenyl ether (Triton X-114) as the extractant. The variables affecting extraction efficiency were evaluated and optimized. Due to the observation that the...
Source: Biological Trace Element Research - January 3, 2019 Category: Biology Authors: Zengin HB, Gürkan R Tags: Biol Trace Elem Res Source Type: research

Selenium Content and/or T-2 Toxin Contamination of Cereals, Soil, and Children's Hair in Some Areas of Heilongjiang and Gansu Provinces, China.
Abstract It has been strongly suggested that selenium deficiency and T-2 contamination in cereals are responsible for the development of Kashin-Beck disease (KBD). In order to assess these risk factors of KBD in the internal and external environments, our team undertook a two-stage survey in some areas of Heilongjiang and Gansu Provinces, China. The selenium content in children's hair (293), cereal (192), and soil (46) samples were determined using the 2, 3-diamino-naphthalene fluorometric assay technique. The T-2 toxin contamination level in the cereal samples (704) was assayed using an ELISA kit. There were...
Source: Biological Trace Element Research - January 3, 2019 Category: Biology Authors: Sun L, Cui S, Deng Q, Liu H, Cao Y, Wang S, Yu J Tags: Biol Trace Elem Res Source Type: research

Selenium-Yeast Alleviated Inflammatory Damage Caused by Lead via Inhibiting Ras/ERK Pathway and Inflammatory Factors in Chicken Skeletal Muscles.
Abstract The aim of this study was to investigate the ameliorative effects of selenium-enriched yeast (Se-yeast) on the inflammatory damage induced by lead (Pb) in chicken skeletal muscles. A total of 108 1-day-old broiler chickens were randomly allocated into four groups (n = 27/group): the control group (C group), the Se-yeast-supplemented group (Se group), the lead-treated group (Pb group), and finally the Se- and Pb-combined group (Pb/Se group). The C group was fed with a basic diet comprising 0.049 mg/kg Se and 0.1 mg/kg Pb while the Se group was fed a Se-yeast diet containing 0.30&nbs...
Source: Biological Trace Element Research - January 2, 2019 Category: Biology Authors: Liu Z, Zhang F, Lu P, Zhao R, Zhang H, Song B, Li L, Wu Z, Wu R Tags: Biol Trace Elem Res Source Type: research

High Concentration of Sodium Metasilicate Impairs Autophagic Flux and Induces Apoptosis in Human Umbilical Vein Endothelial Cells.
This study aims to explore whether high level of sodium metasilicate can induce toxicity effect in human umbilical vein endothelial cells (HUVEC) and the role of autophagy and apoptosis in its toxic mechanism. HUVEC was treated with different level of high silicon and then investigated with respect to morphologic change, cell viability, immunofluorescence, the level of autophagy, and apoptosis-related protein. Moreover, bafilomycin A1 (Baf A1) was applied to detect whether autophagic flux is disrupted, and 3-methyladenine (3-MA, an autophagy inhibitor) was used to determine the relationship between autophagy and apoptosis....
Source: Biological Trace Element Research - January 2, 2019 Category: Biology Authors: Li Z, Liu S, Cao Y, Fu T, Jiang L, Zhang J Tags: Biol Trace Elem Res Source Type: research

Concentrations of Thirteen Trace Metals in Scales of Three Nototheniid Fishes from Antarctica (James Ross Island, Antarctic Peninsula).
In this study, we assessed concentrations of 13 trace metals in the scales of Notothenia coriiceps, Trematomus bernacchii and Gobionotothen gibberifrons caught off the coast of James Ross Island (Antarctic Peninsula). Overall, our results for scales broadly match those of previous studies using different fish and different organs, with most metals found at trace levels and manganese, aluminium, iron and zinc occurring at high levels in all species. This suggests that scales can serve as a useful, non-invasive bioindicator of long-term contamination in Antarctic fishes. High accumulation of manganese, aluminium, iron and zi...
Source: Biological Trace Element Research - January 2, 2019 Category: Biology Authors: Roche K, Kuta J, Sedláček I, Červenka R, Tomanová K, Jurajda P Tags: Biol Trace Elem Res Source Type: research

Nutritional Effects of Zinc on Metabolic Syndrome and Type 2 Diabetes: Mechanisms and Main Findings in Human Studies.
acute;rez A Abstract Zinc (Zn) plays crucial roles in mammalian metabolism. There is increasing interest about the potential beneficial effects of Zn on the prevention or treatment of non-communicable diseases. This review critically analyzes the information related to the role of Zn on the metabolic syndrome (MetS) as well as type 2 diabetes (T2D), and summarizes the biological basis of these potential effects of Zn. There are several mechanisms by which Zn may help to prevent the development or progression of MetS and T2D, respectively. Zn is involved in both insulin secretion and action in peripheral tissues. S...
Source: Biological Trace Element Research - January 2, 2019 Category: Biology Authors: Ruz M, Carrasco F, Rojas P, Basfi-Fer K, Hernández MC, Pérez A Tags: Biol Trace Elem Res Source Type: research

Nutraceutical Effect of Trace Elements as Additional Injectable Doses to Modulate Oxidant and Antioxidant Status, and Improves the Quality of Lamb Meat.
Abstract Our study aimed to evaluate whether zinc, copper, selenium, and manganese subcutaneous mineral application (trace elements) reduced mortality, improved performance, and modulated oxidant and antioxidant balance in lamb meat, thereby improving its quality. We divided the 110 newborn Lacaune lambs into two groups: non-treated (control), and treated (application of minerals) with three doses of 0.33 mL/kg of body weight mineral complex on days of life 1, 30, and 60. All animals were weighed on day of life 1, 30, 60, 90, and 150. At the end of the experiment, 12 animals were slaughtered for physical and ...
Source: Biological Trace Element Research - January 2, 2019 Category: Biology Authors: Cazarotto CJ, Boito JP, Glombowsky P, Baggio RA, Galli GM, Machado G, Bottari NB, Leal MLR, Kessler JD, Baldissera MD, da Silva AS Tags: Biol Trace Elem Res Source Type: research

Evaluation of Whole Blood Trace Element Levels in Chinese Children with Autism Spectrum Disorder.
The objective of the present study was to investigate whole blood levels of trace elements including zinc (Zn), copper (Cu), iron (Fe), and magnesium (Mg) in Chinese children with ASD. In total, 113 children diagnosed with ASD and 141 age-matched and gender-matched neurotypical children, divided into two gender and age groups of preschool age (2-5 years old) and school (6-10 years old) age, were examined. The quantitative analyses of whole blood trace element contents were performed by using flame atomic absorption spectroscopy. In the present study, the children with ASD generally had lower whole blood levels of...
Source: Biological Trace Element Research - January 2, 2019 Category: Biology Authors: Wu LL, Mao SS, Lin X, Yang RW, Zhu ZW Tags: Biol Trace Elem Res Source Type: research