Dietary Intake and Content of Some Micronutrients and Toxic Elements in Two Algerian Spices (Coriandrum sativum L. and Cuminum cyminum L.).
This study presents the elemental concentration obtained in two Algerian spices (Coriandrum sativum L. and Cuminum cyminum L.) evaluated by instrumental neutron activation analysis (INAA), in order to highlight the importance of these spices as a potential source of micronutrients. The daily intake of micronutrients and potentially toxic elements were determined and compared with the recommended values (RDA) and were found to be well below the tolerance limits. Twenty-two elements were assessed, eight essential chemicals were quantified with tendency K > Ca > Na > Fe&thins...
Source: Biological Trace Element Research - June 17, 2018 Category: Biology Authors: Messaoudi M, Begaa S Tags: Biol Trace Elem Res Source Type: research

Heavy Metals in Indigenous Preparations Used for Sex Selection During Pregnancy in India.
Abstract Indigenous preparations (IPs) have evoked a considerable interest in alleviating infections and chronic diseases and improving wellbeing. While such formulations have been a part of traditional practice in several countries and many have been reviewed scientifically for their claims, several of them until date remain to be investigated. A class of IPs for sex selection by Indian pregnant women exists with an aim of begetting a male offspring. In view of the leads obtained from our previous studies on detrimental effects of the newborn, for instance stillbirths and congenital malformations, we attempted to...
Source: Biological Trace Element Research - June 16, 2018 Category: Biology Authors: Ganguli A, Rai P, Balachandran S, Gupta R, Sharma R, Neogi SB Tags: Biol Trace Elem Res Source Type: research

Blood Levels of Trace Elements in Children with Attention-Deficit Hyperactivity Disorder: Results from a Case-Control Study.
This study aimed to investigate the trace element status of zinc (Zn), copper (Cu), iron (Fe), magnesium (Mg), and lead (Pb) in children with ADHD, and to compare them with normal controls. Associations between examined elements and SNAP-IV rating scores of ADHD symptoms were also assessed. Four hundred nineteen children with ADHD (8.8 ± 2.1 years) and 395 matched normal controls (8.9 ± 1.7 years) were recruited in the study. The concentrations of Zn, Fe, Cu, Mg, and Pb in the whole blood were measured by atomic absorption spectrometry. Lower zinc levels (P 
Source: Biological Trace Element Research - June 16, 2018 Category: Biology Authors: Yang R, Zhang Y, Gao W, Lin N, Li R, Zhao Z Tags: Biol Trace Elem Res Source Type: research

Therapeutic Effect of Strontium Ranelate on Bone in Chemotherapy-Induced Osteopenic Rats via Increased Bone Volume and Reduced Bone Loss.
Abstract The purpose of this study was to determine whether treatment with strontium ranelate (SrR) can restore bone mass and strength at a skeletal site with established osteopenia in chemotherapy-induced rats. Forty-five Sprague-Dawley male rats were randomly assigned to three study groups (n = 15 rats per group): normal rats (control group), osteopenic rats (chemo group), and osteopenic rats with SrR (chemo-SrR group). We chose a male rat model that mimicked a clinical setting by weekly intravenous injection of cyclophosphamide at 20 mg/kg. The control and chemo groups were maintained without...
Source: Biological Trace Element Research - June 7, 2018 Category: Biology Authors: Pei Y, Zheng K, Shang G, Wang Y, Wang W, Qiu E, Li S, Zhang X Tags: Biol Trace Elem Res Source Type: research

Evaluation of Arsenic, Cadmium, Nickel and Lead in Common Spices in Pakistan.
Abstract The quantitative assessments and daily intake of arsenic (As), cadmium (Cd), nickel (Ni) and lead (Pb) were conducted in the 26 common spices collected from the market of Hyderabad, Pakistan. Conventional acid digestion procedure was applied for dissolution of common spices and the contents of toxic elemental were determined by graphite furnace atomic absorption spectrometry. The conventional acid digestion method was validated by certified reference materials and standard addition. A wide variability was observed in the levels of toxic elements in common spices. The toxic elements in common spices were f...
Source: Biological Trace Element Research - June 7, 2018 Category: Biology Authors: Baig JA, Bhatti S, Kazi TG, Afridi HI Tags: Biol Trace Elem Res Source Type: research

Lanthanum Chloride Impairs the Blood-Brain Barrier Integrity by Reduction of Junctional Proteins and Upregulation of MMP-9 in Rats.
Abstract Lanthanum could cause cognitive impairment in children and rodent animals. The normal blood-brain barrier (BBB) integrity is essential for protecting the brain from systemic toxins and maintaining the homeostasis for proper neuronal function. BBB dysfunction has been implicated as a potential mechanism of heavy metal-induced neurotoxicity. The present study was aimed to investigate effects of lanthanum on BBB integrity and endothelial junctional complexes in the cerebral cortex of young rats. Animals were exposed to lanthanum chloride (LaCl3) through drinking water under 0, 0.25, 0.5, and 1.0% concentrati...
Source: Biological Trace Element Research - June 6, 2018 Category: Biology Authors: Wu J, Yang J, Lu X, Jin C, Wu S, Zhang L, Hu X, Ma H, Cai Y Tags: Biol Trace Elem Res Source Type: research

Levels of Toxic Elements in Tea Brands Commercialized in Egypt Using Optimized Dual-Pulsed Laser-Induced Spectral Analysis Spectrometer.
We report on qualitative and quantitative analyses of the toxic metal content in a series of 13 various commercial tea brands available in Egypt utilizing optimized double-pulse laser ablation spectroscopy (DP-LAS) and inductively coupled plasma-optical emission spectrometry (ICP-OES). The compositional analysis study utilizing the calibration, DP-LAS system, is based on the recorded accumulation spectra of the laser-created plasma plume. The toxic elements like lead, aluminum, and zinc that exist in the tea brands were accurately identified. Our investigation remarkably revealed that the concentration of Pb, Al, and Zn el...
Source: Biological Trace Element Research - June 6, 2018 Category: Biology Authors: Khalil AAI, Labib OA Tags: Biol Trace Elem Res Source Type: research

Effect of Boron on the Repair of Osteochondral Defect and Oxidative Stress in Rats: an Experimental Study.
In conclusion, it was suggested that boron was not as effective as HA in the repair of osteochondral defect, but its antioxidant property was superior to HA. PMID: 29869015 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - June 4, 2018 Category: Biology Authors: Korkmaz M, Turkmen R, Demirel HH, Saritas ZK Tags: Biol Trace Elem Res Source Type: research

Hematobiochemical Disturbances and Oxidative Stress After Subacute Manganese Chloride Exposure and Potential Protective Effects of Ebselen in Rats.
Abstract The present study aimed to detect the possible disturbances induced by subacute exposure to manganese chloride (MnCl2) on some biomarkers of hematology, clinical chemistry and oxidative stress, serum iron homeostasis, and ferritin status beside the histopathological alterations in hepatic and renal tissues, and the potential protective effects of ebselen on the Mn toxicity were also evaluated. Forty-eight rats were divided into four groups: Group 1 was used as a control. Groups 2, 3, and 4 were administered of ebselen as a single protective dose (15 mg/kg BW) intraperitoneal, daily manganese chloride...
Source: Biological Trace Element Research - June 2, 2018 Category: Biology Authors: Ismail HTH Tags: Biol Trace Elem Res Source Type: research

Correction to: Effect of Selenium on Lipid and Amino Acid Metabolism in Yeast Cells.
ot AM Abstract The authors forgot to include the following information in Materials and Methods. PMID: 29858965 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - June 1, 2018 Category: Biology Authors: Kieliszek M, Błażejak S, Bzducha-Wróbel A, Kot AM Tags: Biol Trace Elem Res Source Type: research

Selenium Biofortification and Antioxidant Activity in Cordyceps militaris Supplied with Selenate, Selenite, or Selenomethionine.
Abstract Selenium (Se) is an essential trace element with multiple functions that may help mitigate adverse health conditions. Cordyceps militaris is an edible mushroom with medicinal properties. The experiment was conducted under artificial cultivation, with five Se concentrations (0, 5, 10, 20, and 40 μg g-1) and three forms of Se (selenate, selenite, and selenomethionine). C. militaris can absorb inorganic from the substrate and convert it to organic Se compounds (selenocystine, selenomethionine, and an unknown species) in fruiting bodies. Compared with the control treatment, Se applications (40&nb...
Source: Biological Trace Element Research - May 31, 2018 Category: Biology Authors: Hu T, Liang Y, Zhao G, Wu W, Li H, Guo Y Tags: Biol Trace Elem Res Source Type: research

Are There as Many Essential and Non-essential Minerals in Hydroponic Strawberry (Fragaria ananassa L.) Compared to Those Grown in Soil?
Abstract The present study aims to compare the contents of minerals (essential major-K, Ca, Mg, Na, P, S; essential trace-Fe, Mn, Zn, Cu, B, Mo, As, Se, Ni, V, Cr, Co; non-essential-Sn, Ga, Li, Be, Rb, Sr, Al, Pd, Cd, Hg, Pb, Ge) in strawberry (stem, leaf, and fruit) cultivated in two different cultivation systems, soil and hydroponic. The concentrations of 30 minerals in the acid-digested strawberry samples were determined by ICP-MS and ICP-OES. Hydroponic strawberry (leaf > fruit > stem) indicated higher values for most minerals which were below the plant toxicity levels. In lea...
Source: Biological Trace Element Research - May 30, 2018 Category: Biology Authors: Jeon SH, Kuppusamy S, Yoon YE, Kim HT, Lee YB Tags: Biol Trace Elem Res Source Type: research

Green Engineered Biomolecule-Capped Silver Nanoparticles Fabricated from Cichorium intybus Extract: In Vitro Assessment on Apoptosis Properties Toward Human Breast Cancer (MCF-7) Cells.
Abstract The current experiment reveals the anticancer properties of silver nanoparticles (AgNPs) synthesized using aqueous leaf extract of Cichorium intybus, a significant medicinal plant. The characteristics of AgNPs were continuously studied by powder X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), zeta potential, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and energy-dispersive spectroscopy (EDS) analysis. Current microscopic results show that produced AgNPs were spherical in shape with an average size of 17.17 nm. A strong peak between 2 and 4 ...
Source: Biological Trace Element Research - May 28, 2018 Category: Biology Authors: Behboodi S, Baghbani-Arani F, Abdalan S, Sadat Shandiz SA Tags: Biol Trace Elem Res Source Type: research

Co-exposure to an Aryl Hydrocarbon Receptor Endogenous Ligand, 6-Formylindolo[3,2-b]carbazole (FICZ), and Cadmium Induces Cardiovascular Developmental Abnormalities in Mice.
Abstract 6-Formylindolo[3,2-b]carbazole (FICZ) is a signal substance and an endogenous activator of aryl hydrocarbon receptor (AHR). Cadmium (Cd) is an environmental pollutant that can activate both AHR and Wnt/β-catenin signaling pathways. We aimed to determine how dysregulated signaling through AHR-Wnt/β-catenin cross-talk can influence mice heart development. Mice fetuses were exposed to Cd alone or in combination with FICZ in gestation day (GD) 0. In GD18, fetuses were harvested and randomly divided into two parts for stereological and molecular studies. Stereological and tessellation results reveale...
Source: Biological Trace Element Research - May 28, 2018 Category: Biology Authors: Omidi M, Niknahad H, Noorafshan A, Fardid R, Nadimi E, Naderi S, Bakhtari A, Mohammadi-Bardbori A Tags: Biol Trace Elem Res Source Type: research

Trivalent Chromium Supplementation Ameliorates Oleic Acid-Induced Hepatic Steatosis in Mice.
This study aimed to investigate the beneficial effects and potential mechanisms of Cr(III) on hepatic steatosis in an oleic acid (OA) induced mice model. Mice were fed with high OA for 12 weeks to induce lipid accumulation, and co-administrated with Cr(III) supplementation. Indexes of liver lipid accumulation, associated lipid genes expression, fatty acids (FAs) profile and inflammatory cytokines were analyzed. The data showed that Cr(III) supplementation could attenuate disease progress of hepatic steatosis and protect liver from high OA. After Cr(III) supplementation, elevated body weight and liver injury in steatos...
Source: Biological Trace Element Research - May 24, 2018 Category: Biology Authors: Wang S, Wang J, Liu Y, Li H, Wang Q, Huang Z, Liu W, Shi P Tags: Biol Trace Elem Res Source Type: research

Influence of Chronic Toxicity, Lipid Metabolism, Learning and Memory Ability, and Related Enzyme in Sprague-Dawley Rats by Long-Term Chromium Malate Supplementation.
Abstract In our previous study, chromium malate is beneficial for type 2 diabetic rats in control glycometabolism and lipid metabolism. The present study was designed to observe the chronic toxicity, lipid metabolism, learning and memory ability, and related enzymes of chromium malate in rats during the year. The results showed that pathological, toxic, feces, and urine of chromium malate (at daily doses of 10.0, 15.0, and 20.0 μg Cr/kg bm) did not change measurably. Chromium malate (at daily doses of 15.0 and 20.0 μg Cr/kg bm) could significantly reduce the levels of total cholesterol (TC), LDL, a...
Source: Biological Trace Element Research - May 24, 2018 Category: Biology Authors: Feng W, Li Q, Wang W, Chen Y, Zhang W, Zhao T, Mao G, Wu X, Yang L Tags: Biol Trace Elem Res Source Type: research

Effects of Restoring the Primary Dentition with Stainless-Steel Crowns on Children's Salivary Nickel and Chromium Levels, and the Associations with Saliva pH: a Preliminary Before-After Clinical Trial.
Abstract Nickel and chromium existing in stainless-steel crowns (SSCs, used in pediatric dentistry) might be cytotoxic and allergenic. However, no in vivo studies have examined their salivary levels in children using SSCs, or in young children without SSCs. Also, the effect of acidity on metal ion release has not yet been evaluated in any previous in vivo studies in the whole literature. Therefore, this preliminary before-after clinical trial was conducted. Salivary nickel/chromium levels of 30 children before and after 2 months of placement of SSCs were measured using atomic absorption spectrophotometry. Sal...
Source: Biological Trace Element Research - May 23, 2018 Category: Biology Authors: Basir L, Meshki R, Behbudi A, Rakhshan V Tags: Biol Trace Elem Res Source Type: research

Calcium Channels, Rho-Kinase, Protein Kinase-C, and Phospholipase-C Pathways Mediate Mercury Chloride-Induced Myometrial Contractions in Rats.
Abstract Adverse effects of mercury on female reproduction are reported; however, its effect on myogenic activity of uterus and mechanism thereof is obscure. Present study was undertaken to unravel the mechanistic pathways of mercuric chloride (HgCl2)-induced myometrial contraction in rats. Isometric tension in myometrial strips of rats following in vitro exposure to HgCl2 was recorded using data acquisition system-based physiograph. HgCl2 produced concentration-dependent (10 nM-100 μM) uterotonic effect which was significantly (p 
Source: Biological Trace Element Research - May 21, 2018 Category: Biology Authors: Koli S, Prakash A, Choudhury S, Mandil R, Garg SK Tags: Biol Trace Elem Res Source Type: research

Mercury Involvement in Neuronal Damage and in Neurodegenerative Diseases.
zon E Abstract Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis are characterized by a chronic and selective process of neuronal cell death. Although the causes of neurodegenerative diseases remain still unknown, it is now a well-established idea that more factors, such as genetic, endogenous, and environmental, are involved. Among environmental causes, the accumulation of mercury, a heavy metal considered a toxic agent, was largely studied as a probable factor involved in neurodegenerative disease course. Mercury exists in three mai...
Source: Biological Trace Element Research - May 18, 2018 Category: Biology Authors: Cariccio VL, Samà A, Bramanti P, Mazzon E Tags: Biol Trace Elem Res Source Type: research

Preconcentration and Determination of Trace Nickel and Cobalt in Milk-Based Samples by Ultrasound-Assisted Cloud Point Extraction Coupled with Flame Atomic Absorption Spectrometry.
In this study, ultrasound-assisted cloud point extraction (UA-CPE) method was developed for the determination of Ni(II) and Co(II) in milk-based products. After extraction and preconcentration, the Ni(II) and Co(II) contents of samples were determined by flame atomic absorption spectrometry (FAAS). After their complexation with hydroxy naphthol blue (HNB) in the presence of cationic surfactant, CTAB at pH 4.0, the Ni(II) and Co(II) were taken within the micellar phase of nonionic surfactant, TX-114. The micellar phase containing the analytes were diluted to a volume of 0.7 mL with 1.0-mol/L HNO3 in ethanol to reduce i...
Source: Biological Trace Element Research - May 18, 2018 Category: Biology Authors: Temel NK, Sertakan K, Gürkan R Tags: Biol Trace Elem Res Source Type: research

Dietary Intake and Content of Cu, Mn, Fe, and Zn in Selected Cereal Products Marketed in Poland.
ska W Abstract This paper aims to verify whether cereal products are a good source of Cu, Mn, Fe, and Zn in the diets of Poles. The study material comprised of 445 cereal products including baked goods, breakfast cereals and groats, pasta, and rice. Products that required culinary treatment (pasta, groats, rice) were boiled in drinking quality water as recommended by the producer. The content of Cu, Mn, Fe, and Zn was determined by using the FAAS method. The average content of microelements in the analyzed products can be represented as Fe (17.9 mg kg-1 ± 10.3) > Zn ...
Source: Biological Trace Element Research - May 18, 2018 Category: Biology Authors: Winiarska-Mieczan A, Kowalczuk-Vasilev E, Kwiatkowska K, Kwiecień M, Baranowska-Wójcik E, Kiczorowska B, Klebaniuk R, Samolińska W Tags: Biol Trace Elem Res Source Type: research

Selenium Ameliorates AFB1-Induced Excess Apoptosis in Chicken Splenocytes Through Death Receptor and Endoplasmic Reticulum Pathways.
Abstract Aflatoxin B1 (AFB1) can cause hepatotoxicity, genotoxicity, and immunosuppressive effects for a variety of organisms. Selenium (Se), as an essential nutrient element, plays important protective effects against cell apoptosis induced by AFB1. This research aimed to reveal the ameliorative effects of selenium on AFB1-induced excess apoptosis in chicken splenocytes through death receptor and endoplasmic reticulum pathways in vivo. Two hundred sixteen neonatal chickens, randomized into four treatments, were fed with basal diet (control treatment), 0.4 mg/kg Se supplement (+Se treatment), 0.6 mg/kg A...
Source: Biological Trace Element Research - May 16, 2018 Category: Biology Authors: Fang J, Zhu P, Yang Z, Peng X, Zuo Z, Cui H, Ouyang P, Shu G, Chen Z, Huang C, Liu W Tags: Biol Trace Elem Res Source Type: research

Heme and Non-heme Iron on Growth Performances, Blood Parameters, Tissue Mineral Concentration, and Intestinal Morphology of Weanling Pigs.
Abstract This experiment was conducted to evaluate the effects of heme and non-heme iron sources on growth performances, blood parameters, tissue mineral concentration, and intestinal morphology in weanling pigs. At 25 days of age, 32 newly weaned piglets (Duroc × Landrace × Yorkshire; 8.66 ± 0.59 kg) were allocated to one of the following dietary treatments: control group (basal diet with no extra iron addition), FeSO4 group (basal diet + 100 mg Fe/kg as FeSO4), Fe-Gly group (basal diet + 100 mg Fe/kg as Fe-Gly), and He...
Source: Biological Trace Element Research - May 16, 2018 Category: Biology Authors: Zhuo Z, Yu X, Li S, Fang S, Feng J Tags: Biol Trace Elem Res Source Type: research

Requirement of TGF β Signaling for Effect of Fluoride on Osteoblastic Differentiation.
Requirement of TGFβ Signaling for Effect of Fluoride on Osteoblastic Differentiation. Biol Trace Elem Res. 2018 May 16;: Authors: Zhang J, Jiang N, Yu H, Yu X, Guo F, Zhao Z, Xu H Abstract Research focused on transforming growth factor β (TGFβ) signaling in osteoblast is gradually increasing, whereas literature is rare in terms of fluorosis. This work aimed to investigate how TGFβ signaling participated in regulation of the osteoblast by different doses of fluoride treatment. Bone marrow stem cells (BMSCs) were developed into osteoblastic cells and exposed to 1, 4, and 16 mg/L...
Source: Biological Trace Element Research - May 16, 2018 Category: Biology Authors: Zhang J, Jiang N, Yu H, Yu X, Guo F, Zhao Z, Xu H Tags: Biol Trace Elem Res Source Type: research

Carnosine and Histidine Supplementation Blunt Lead-Induced Reproductive Toxicity through Antioxidative and Mitochondria-Dependent Mechanisms.
This study was designed to investigate whether carnosine (CAR) and histidine (HIS) supplementation would mitigate the Pb-induced reproductive toxicity in male rats. Animals received Pb (20 mg/kg/day, oral, 14 consecutive days) alone or in combination with CAR (250 and 500 mg/kg/day, oral, 14 consecutive days) or HIS (250 and 500 mg/kg/day, oral, 14 consecutive days). Pb toxicity was evident in the reproductive system by a significant increase in tissue markers of oxidative stress along with severe histopathological changes, seminal tubule damage, tubular desquamation, low spermatogenesis index, poor sperm pa...
Source: Biological Trace Element Research - May 16, 2018 Category: Biology Authors: Ommati MM, Jamshidzadeh A, Heidari R, Sun Z, Zamiri MJ, Khodaei F, Mousapour S, Ahmadi F, Javanmard N, Shirazi Yeganeh B Tags: Biol Trace Elem Res Source Type: research

Zinc Supplementation Ameliorates Diabetic Cataract Through Modulation of Crystallin Proteins and Polyol Pathway in Experimental Rats.
Abstract Non-enzymatic glycation of lens proteins and elevated polyol pathway in the eye lens have been the characteristic features of a diabetic condition. We have previously reported the benefits of zinc supplementation in reducing hyperglycemia and associated metabolic abnormalities and oxidative stress in diabetic rats. The current study explored whether zinc supplementation protects against cataractogenesis through modulation of glycation of lens proteins, elevated polyol pathway, oxidative stress, and proportion of different heat shock proteins in the eye lens of diabetic rats. Streptozotocin-induced diabeti...
Source: Biological Trace Element Research - May 13, 2018 Category: Biology Authors: Barman S, Srinivasan K Tags: Biol Trace Elem Res Source Type: research

Association Between Selenium and Malondialdehyde as an Efficient Biomarker of Oxidative Stress in Infantile Cardiac Surgery.
to VA Abstract The present work describes a method to quantify the level of oxidative stress in infantile cardiac surgery. Fifteen patients, 6 girls and 9 boys, aged between 3 months and 16 years were divided into three groups. The first group sought to quantify the oxidative stress from differing concentrations of selenium. The second group used malondialdehyde as an indicator of oxidative stress. Finally, the third group quantified oxidative stress by normalizing the selenium concentration via malondialdehyde. Blood aliquots of 1.50 ml, drawn from the radial artery, were collected and centrifuged ...
Source: Biological Trace Element Research - May 12, 2018 Category: Biology Authors: de Oliveira Ulbrecht MO, Gonçalves DA, Zanoni LZG, do Nascimento VA Tags: Biol Trace Elem Res Source Type: research

Determination of Seasonal Vitamin and Mineral Contents of Sea Bream (Sparus aurata L., 1758) Cultured in Net Cages in Central Black Sea Region.
This study aimed to determine the seasonal vitamin and mineral contents of sea bream (Sparus aurata) cultured in net cages in Central Black Sea region. The average seasonal A, D3, and E vitamins values in fish meat were between 0.27 ± 0.02-0.60 ± 0.00, 0.98 ± 0.01-1.70 ± 0.00, and 3.10 ± 0.14-6.00 ± 0.21 mg/kg, respectively (p 
Source: Biological Trace Element Research - May 12, 2018 Category: Biology Authors: Öztürk DK, Baki B, Karayücel İ, Öztürk R, Gören GU, Karayücel S Tags: Biol Trace Elem Res Source Type: research

Ecological and Human Health Risk Assessment of Heavy Metal Content of Atmospheric Dry Deposition, a Case Study: Kermanshah, Iran.
Abstract The present study was intended to investigate the ecological and human health risk of cobalt, nickel, and vanadium in the atmospheric dry deposition of the Kermanshah city, Iran, in 2015. Totally 54 samples of atmospheric dry deposition were collected from the three regions of the city with different traffic intensity, and after acid digestion of the samples with ultrapure concentrated HNO3, the total contents of the metals were determined using inductively coupled plasma optical emission spectrometer (ICP-OES). Also, all statistical analyses were performed using the SPSS statistical package. The atmosphe...
Source: Biological Trace Element Research - May 12, 2018 Category: Biology Authors: Sobhanardakani S Tags: Biol Trace Elem Res Source Type: research

Selenium Nanoparticles Induce the Chemo-Sensitivity of Fluorouracil Nanoparticles in Breast and Colon Cancer Cells.
Abstract Drug resistance is a major challenge of breast and colon cancer therapies leading to treatment failure. The main objective of the current study is to investigate whether selenium nanoparticles (nano-Se) can induce the chemo-sensitivity of 5-fluorouracil (FU)-encapsulated poly (D, L-lactide-co-glycolide) nanoparticles (nano-FU) in breast and colon cancer cell lines. Nano-Se and nano-FU were synthesized and characterized, then applied individually or in combination upon MCF7, MDA-MB-231, HCT 116, and Caco-2 cancerous cell lines. Cytotoxicity, cellular glucose uptake, and apoptosis, as well as malondialdehyd...
Source: Biological Trace Element Research - May 11, 2018 Category: Biology Authors: Abd-Rabou AA, Shalby AB, Ahmed HH Tags: Biol Trace Elem Res Source Type: research

Perinatal Exposure to Arsenic in Drinking Water Alters Glutamatergic Neurotransmission in the Striatum of C57BL/6 Mice.
In this study, the body weight, glutamate content, and expression of vesicular glutamate transporter 2 (VGLUT2) and metabotropic glutamate receptors mGluR2 and mGluR3 was examined in the striatum of offspring following treatment of the dams with As (10 or 100 mg/L NaAsO2 in drinking water). At postnatal day 21, body weight was decreased significantly, whereas the glutamate content in the striatum of offspring in the 100-mg/L As group were not significantly different from those in the control group. Although mGluR3 expression was not significantly different, VGLUT2 and mGluR2 expression was significantly lower in the s...
Source: Biological Trace Element Research - May 10, 2018 Category: Biology Authors: Sung K, Kim M, Kim H, Hwang GW, Kim K Tags: Biol Trace Elem Res Source Type: research

Effects of Humic Acids in Chronic Lead Poisoning.
nská G, Vaško L Abstract Chronic exposure to lead causes disruption to energy production mechanisms and tissue damage, in particular through its binding to thiol groups and competition for zinc binding sites. We investigated the possibility of preventing the consequences of chronic lead poisoning by administration of three different doses of humic acids (HAs) into feed with the aim of establishing an effective HA dose. During the 10-week experiment, a sub-lethal dose of lead acetate was given to rats during the first 5 weeks, with continuous administration of HA over 10 weeks. Measurements ...
Source: Biological Trace Element Research - May 10, 2018 Category: Biology Authors: Vašková J, Krempaská K, Žatko D, Mudroň P, Glinská G, Vaško L Tags: Biol Trace Elem Res Source Type: research

Toxicological Aspect of Some Selected Medicinal Plant Samples Collected from Djelfa, Algeria Region.
Abstract Instrumental neutron activation analysis (INAA) has been used to determine the concentration of some toxic chemical elements in a variety of aromatic plants samples collected from Djelfa region. In the present work, eight medicinal plants were examined, such as Artemisia herba-alba Asso., Artemisia compestris L., Laurus nobilis L., Origanum vulgare L., Mentha spicata L., Rosmarinus officinalis L., Mentha pulegium L., and Pistacia lentiscus L. The levels of toxic elements were compared to their daily total intake; Arsenic was present in all plant species examined, with a concentration ranging from 0.18 to ...
Source: Biological Trace Element Research - May 10, 2018 Category: Biology Authors: Begaa S, Messaoudi M Tags: Biol Trace Elem Res Source Type: research

Positive PCNA and Ki-67 Expression in the Testis Correlates with Spermatogenesis Dysfunction in Fluoride-Treated Rats.
Abstract The present study aimed to evaluate the effect of fluoride (F) on spermatogenesis in male rats. F- at 50 and 100 mg/L was administered for 70 days, after which the testicular and epididymis tissues were collected to observe the histopathological structure under a light microscope. The ultrastructure of the testis and sperm was also examined via transmission electron microscopy. The apoptosis of spermatogenic cells was measured through terminal deoxynucleotidyl transferase dUTP nick end labeling staining. The expression of proliferation factors, namely, proliferating cell nuclear antigen (PCNA) a...
Source: Biological Trace Element Research - May 10, 2018 Category: Biology Authors: Zhao WP, Wang HW, Liu J, Tan PP, Luo XL, Zhu SQ, Chen XL, Zhou BH Tags: Biol Trace Elem Res Source Type: research

Zinc and Metallothionein in the Development and Progression of Dental Caries.
Abstract Chronic oxidative stress and reactive oxygen species (ROS) in oral cavity as well as acidic pH on dental enamel surface due to the metabolic activities of bacterial plaque are the major contributors in the development and progression of dental caries. Along with other factors, deposition or dissolution Ca and Mg mostly determines the re- or demineralization of dental enamel. Zn plays an important role for both Ca and Mg bioavailability in oral cavity. Metallothionein (MT), a group of small molecular weight, cysteine-rich proteins (~ 7 kDa), is commonly induced by ROS, bacterial infection, and ...
Source: Biological Trace Element Research - May 9, 2018 Category: Biology Authors: Rahman MT, Hossain A, Pin CH, Yahya NA Tags: Biol Trace Elem Res Source Type: research

Du-Zhong (Eucommia ulmoides Oliv.) Cortex Extract Alleviates Lead Acetate-Induced Bone Loss in Rats.
Abstract The purpose of this study was to evaluate the protective effect of Du-Zhong cortex extract (DZCE) on lead acetate-induced bone loss in rats. Forty female Sprague-Dawley rats were randomly divided into four groups: group I (control) was provided with distilled water. Group II (PbAc) received 500 ppm lead acetate in drinking water for 60 days. Group III (PbAc+DZCE) received 500 ppm lead acetate in drinking water, and given intragastric DZCE (100 mg/kg body weight) for 60 days. Group IV (DZCE) was given intragastric DZCE (100 mg/kg body weight) for 60 days. The bone mineral...
Source: Biological Trace Element Research - May 9, 2018 Category: Biology Authors: Qi S, Zheng H, Chen C, Jiang H Tags: Biol Trace Elem Res Source Type: research

Identification of Biomarkers of Mercury Contamination in Brachyplatystoma filamentosum of the Madeira River, Brazil, Using Metalloproteomic Strategies.
s Padilha P Abstract Predator fish can accumulate high levels of mercury, which qualifies them as potential indicators of this toxic metal. The predatory species Brachyplatystoma filamentosum, popularly known as filhote, is among the most consumed species in the Brazilian Amazon. Continuing the metalloproteomic studies of mercury in Amazonian fishes that have been developed in the last 5 years, the present paper provides the data of protein characterization associated with mercury in muscle and liver samples of filhote (Brachyplatystoma filamentosum) collected in the Madeira River, Brazilian Amazon. The mercu...
Source: Biological Trace Element Research - May 8, 2018 Category: Biology Authors: de Queiroz JV, Vieira JCS, de Oliveira G, Braga CP, da Cunha Bataglioli I, da Silva JM, de Paula Araújo WL, de Magalhães Padilha P Tags: Biol Trace Elem Res Source Type: research

Role of Melatonin in Aluminum-Related Neurodegenerative Disorders: a Review.
go JL Abstract Aluminum (Al), a potentially neurotoxic element, provokes various adverse effects on human health such as dialysis dementia, osteomalacia, and microcytic anemia. It has been also associated with serious neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic lateral sclerosis, and Parkinsonism dementia of Guam. The "aluminum hypothesis" of AD assumes that the metal complexes can potentiate the rate of aggregation of amyloid-β (Aβ), enhancing the toxicity of this peptide, and being able of contributing to the pathogenesis of AD. It has been supported by a number o...
Source: Biological Trace Element Research - May 7, 2018 Category: Biology Authors: Esparza JL, Gómez M, Domingo JL Tags: Biol Trace Elem Res Source Type: research

The Safety Assessment of Toxic Metals in Commonly Used Pharmaceutical Herbal Products and Traditional Herbs for Infants in Jordanian Market.
The objective of this study was to assess the levels of contamination by toxic metals (Pb, Al, Ni, Cd and As) that may be present in 25 infant pharmaceutical herbal products and 15 traditional herbs in Jordan. Both products and medicinal herbs are currently prescribed by paediatricians. They are available as over-the-counter medicines and are sold the in herbal market, ensuring easy accessibility for parents. Inductively coupled plasma-optical emission spectroscopy (ICP-OES), with limit of detections (LODs) of 0.10, 1.00, 0.20, 0.15 and 2.00 mg.kg-1 for Pb, Al, Ni, Cd and As respectively, was employed to measure the l...
Source: Biological Trace Element Research - May 5, 2018 Category: Biology Authors: Alhusban AA, Ata SA, Shraim SA Tags: Biol Trace Elem Res Source Type: research

A Comparative Study of Iodized Salt Programs: Shanghai and Switzerland.
Abstract Both Shanghai and Switzerland are developed regions with long-standing salt iodization programs and periodic monitoring. However, the two regions have their own approach to the implementation of the iodized salt policy. In Shanghai, monitoring was carried out every few years, using probability-proportional-to-size sampling technique to select 30 sampling units. Each unit consisted of more than 12 pregnant women and one randomly selected primary school. Urine samples were then taken from the chosen pregnant women and randomly recruited students of that school for iodine test. Data of Switzerland used in th...
Source: Biological Trace Element Research - May 5, 2018 Category: Biology Authors: Wang Z, Liu P, Su X, Zou S, Song J, Liu S Tags: Biol Trace Elem Res Source Type: research

Effect of Selenium Nanoparticle Supplementation on Tissue Inflammation, Blood Cell Count, and IGF-1 Levels in Spinal Cord Injury-Induced Rats.
In conclusion, we speculate that the decrease in the number of inflammatory cells after oral administration of the selenium nanoparticles is due to the neuroprotective effects of this nanoparticle. PMID: 29730750 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - May 5, 2018 Category: Biology Authors: Javdani M, Habibi A, Shirian S, Kojouri GA, Hosseini F Tags: Biol Trace Elem Res Source Type: research

Moringa oleifera Leaves Extract Protects Titanium Dioxide Nanoparticles-Induced Nephrotoxicity via Nrf2/HO-1 Signaling and Amelioration of Oxidative Stress.
In conclusion, MO can inhibit nephrotoxicity by suppressing oxidative stress and inflammation. These effects are suggested to be mediated by activating Nrf2/HO-1.The biochemical analysis and histopathological finding reinforced these results. These data support the antioxidant properties' nutraceutical role of MO against TiO2NPs-induced toxicity. PMID: 29728821 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - May 4, 2018 Category: Biology Authors: Abdou KH, Moselhy WA, Mohamed HM, El-Nahass ES, Khalifa AG Tags: Biol Trace Elem Res Source Type: research

Effect of Cooking on Speciation and In Vitro Bioaccessibility of Hg and As from Rice, Using Ordinary and Pressure Cookers.
This study provides novel insights into Hg and As exposure due to rice cooking. PMID: 29725934 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - May 3, 2018 Category: Biology Authors: Liao W, Wang G, Li K, Zhao W, Wu Y Tags: Biol Trace Elem Res Source Type: research

Health Risk Assessment and Urinary Excretion of Children Exposed to Arsenic through Drinking Water and Soils in Sonora, Mexico.
ntenegro MM Abstract Environmental arsenic exposure is associated with increased risk of non-cancerous chronic diseases and a variety of cancers in humans. The aims of this study were to carry out for the first time a health risk assessment for two common arsenic exposure routes (drinking water and soil ingestion) in children living in the most important agricultural areas in the Yaqui and Mayo valleys in Sonora, Mexico. Drinking water sampling was conducted in the wells of 57 towns. A cross-sectional study was done in 306 children from 13 villages in the valleys. First morning void urine samples were analyzed for...
Source: Biological Trace Element Research - May 2, 2018 Category: Biology Authors: García-Rico L, Meza-Figueroa D, Jay Gandolfi A, Del Rivero CI, Martínez-Cinco MA, Meza-Montenegro MM Tags: Biol Trace Elem Res Source Type: research

Protective Effect of Ganoderma Triterpenoids on Cadmium-Induced Testicular Toxicity in Chickens.
Abstract Studies have shown that cadmium can cause chicken testicular damage, but a protective effect of Ganoderma triterpenoids on cadmium-induced testicular damage in chickens has not yet been reported. The present study was designed to research the protective effect of Ganoderma triterpenoids on cadmium-induced testicular damage in chicken. Eighty healthy 7-day-old Hyline egg laying chickens were randomly divided into four groups with 20 in each group. The control group was fed with normal full-fodder, the model group was fed with normal full-fodder with 140 mg/kg of CdCl2, the Ganoderma triterpenoid treat...
Source: Biological Trace Element Research - May 2, 2018 Category: Biology Authors: Wang H, Zhang R, Song Y, Li T, Ge M Tags: Biol Trace Elem Res Source Type: research

Liver Proteome of Mice with Distinct Genetic Susceptibilities to Fluorosis Treated with Different Concentrations of F in the Drinking Water.
This study evaluated the effects of F on the liver proteome of mice susceptible (A/J) or resistant (129P3/J) to the effects of F. Weanling male A/J (n = 12) and 129P3/J (n = 12) mice were housed in pairs and assigned to two groups given low-F food and drinking water containing 15 or 50 ppm F for 6 weeks. Liver proteome profiles were examined using nano-LC-ESI-MS/MS. Difference in expression among the groups was determined using the PLGS software. Treatment with the lower F concentration provoked more pronounced alterations in fold change in liver proteins in comparison to the treatment wit...
Source: Biological Trace Element Research - April 29, 2018 Category: Biology Authors: Khan ZN, Sabino IT, de Souza Melo CG, Martini T, da Silva Pereira HAB, Buzalaf MAR Tags: Biol Trace Elem Res Source Type: research

Chronic Cadmium Exposure Accelerates the Development of Atherosclerosis and Induces Vascular Dysfunction in the Aorta of ApoE-/- Mice.
Abstract Cadmium exposure is related to cardiovascular diseases, including hypertension, atherosclerosis, increased oxidative stress, endothelial dysfunction, and specific biochemical changes induced by this metal. Thus, we aimed to investigate whether cadmium exposure induces endothelial dysfunction, accelerates atherosclerotic plaque formation in the aorta, and enhances oxidative stress in apolipoprotein E knockout (ApoE-/-) mice. Experiments were performed in 14-week-old male wild-type and ApoE-/- mice. ApoE-/- mice received cadmium (CdCl2 100 mg/L in drinking water for 28 days) or vehicle (distilled ...
Source: Biological Trace Element Research - April 29, 2018 Category: Biology Authors: Oliveira TF, Batista PR, Leal MA, Campagnaro BP, Nogueira BV, Vassallo DV, Meyrelles SS, Padilha AS Tags: Biol Trace Elem Res Source Type: research

Improved Magnesium Levels in Morbidly Obese Diabetic and Non-diabetic Patients After Modest Weight Loss.
eth J Abstract Serum magnesium (Mg) is reported to be reduced in individuals with obesity, hypertension, and diabetes mellitus and has been suggested as a marker for metabolic syndrome. We have studied changes in serum Mg concentrations in a group of obese patients (n = 92) with and without diabetes mellitus after weight loss induced by dieting and bariatric surgery. At inclusion, 11% (10/92) of the population had severe Mg deficiency (
Source: Biological Trace Element Research - April 28, 2018 Category: Biology Authors: Mikalsen SM, Bjørke-Monsen AL, Whist JE, Aaseth J Tags: Biol Trace Elem Res Source Type: research

Tissue Trace Elements and Lipid Peroxidation in Breeding Female Bank Voles Myodes glareolus.
Abstract Recent studies have demonstrated that reproduction reduces oxidative damage in various tissues of small mammal females. The present work was designed to determine whether the reduction of oxidative stress in reproductive bank vole females was associated with changes in tissue trace elements (iron, copper, zinc) that play an essential role in the production of reactive oxygen species. Lipid peroxidation (a marker of oxidative stress) and iron concentration in liver, kidneys, and skeletal muscles of reproducing bank vole females that weaned one litter were significantly lower than in non-reproducing females...
Source: Biological Trace Element Research - April 27, 2018 Category: Biology Authors: Bonda-Ostaszewska E, Włostowski T, Łaszkiewicz-Tiszczenko B Tags: Biol Trace Elem Res Source Type: research

Analysis of the Relationship Between Hemorheologic Parameters, Aluminum, Manganese, and Selenium in Smokers.
In conclusion, increased Al, Mn, and hemorheological parameters and decreased Se and ODI45 might result from inflammatory response in defense mechanism in smokers without diagnosis of COPD. Our results point out that serum Al, Mn, and Se with hemorheological parameters may be beneficial markers of tissue oxygenation and defense mechanism before the clinic onset of COPD in smokers. PMID: 29704205 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - April 27, 2018 Category: Biology Authors: Ates Alkan F, Karis D, Cakmak G, Ercan AM Tags: Biol Trace Elem Res Source Type: research