High Doses of Copper and Mercury Changed Cecal Microbiota in Female Mice.
Abstract The aim of the present study was to investigate the effects of high doses of copper (Cu) and mercury (Hg) on the cecal microbiota in female mice. Forty-eight Kunming mice were randomly divided into the control group (CCk group), the Cu group (CCu group), the Hg group (CHg group), and the Cu + Hg group (CCH group). At the 90th day, cecal tissues were prepared for histopathological analysis and cecal contents for analysis by 16S rRNA sequencing method. Cecal tissues from treatment groups had histopathological lesions including increased thickness of inner muscularis and outer muscularis, widen...
Source: Biological Trace Element Research - August 13, 2018 Category: Biology Authors: Ruan Y, Wu C, Guo X, Xu Z, Xing C, Cao H, Zhang C, Hu G, Liu P Tags: Biol Trace Elem Res Source Type: research

Evaluation of Essential and Toxic Elements in Amniotic Fluid and Maternal Serum at Birth.
This study was conducted among 175 healthy pregnant Caucasian European women aged 18-42. AF and maternal blood samples were collected during delivery. An inductively coupled plasma mass spectrometry (ICP-MS) technique was used to determine the levels of Mg, Co, Cu, Zn, Sr, Cd, Ba, Pb, U, Ca, Cr, Al, Mn, V, Fe, As, Se and Sb in AF and MS. The range of reference values was calculated for all analyzed elements in the serum and AF. The mean concentrations of elements, except Pb, were generally higher in MS than in AF. Multiple regression analysis showed that the maternal/newborn body mass (MBM/NBM) ratio was a strong negative ...
Source: Biological Trace Element Research - August 10, 2018 Category: Biology Authors: Kocyłowski R, Grzesiak M, Gaj Z, Lorenc W, Bakinowska E, Barałkiewicz D, von Kaisenberg CS, Suliburska J Tags: Biol Trace Elem Res Source Type: research

Mineral Composition of Amazonian Fruits by Flame Atomic Absorption Spectrometry Using Multivariate Analysis.
This study aimed to evaluate the mineral composition in native and non-native Amazonian fruits using flame atomic absorption spectrometry (FAAS) and multivariate methods, such as principal component analysis (PCA) and hierarchical cluster analysis (HCA), in order to conduct a more thorough evaluation of the original data. The accuracy was checked by certified reference material analysis (Poplar leaves) and spike experiments. The results of the analysis were in agreement with the certified values, with analytical recoveries for all analytes in an acceptable range from 82 to 113%, and relative standard deviations (RSD) were ...
Source: Biological Trace Element Research - August 10, 2018 Category: Biology Authors: Alves BSF, Pereira Junior JB, Carvalho FIM, Dantas Filho HA, Fernandes Dantas KG Tags: Biol Trace Elem Res Source Type: research

Transcriptional Study Revealed That Boron Supplementation May Alter the Immune-Related Genes Through MAPK Signaling in Ostrich Chick Thymus.
The objective of this study is to construct a digital gene expression tag profile to identify genes potentially related to immune response in the ostrich. Exposure to boron leads to an immune response in the ostrich, although the underlying mechanism remains obscure. Thus, a dire need of biological resource in the form of transcriptomic data for ostriches arises to key out genes and to gain insights into the function of boron on the immune response of thymus. For this purpose, RNA-Seq analysis was performed using the Illumina technique to investigate differentially expressed genes in ostrich thymuses treated with different...
Source: Biological Trace Element Research - August 9, 2018 Category: Biology Authors: Xiao K, Yang K, Wang J, Sun P, Huang H, Khaliq H, Naeem MA, Zhong J, Peng K Tags: Biol Trace Elem Res Source Type: research

The Relationship between Dietary, Serum and Hair Levels of Minerals (Fe, Zn, Cu) and Glucose Metabolism Indices in Obese Type 2 Diabetic Patients.
cio Z Abstract The aim of this study was to assess the levels of Zn, Fe and Cu in the serum and hair, and dietary intake of type 2 diabetic patients and their association with glucose and lipid indices. The study was conducted on 62 people aged 40-78 years (31 diabetic patients and 31 healthy subjects, who were the control group). The content of trace elements in the hair and serum was analysed with the AAS method. The serum insulin, HbA1c, glucose, total cholesterol and triacylglycerol concentrations were measured by means of RIA, HPLC and colorimetric methods, respectively. The diabetic patients were found ...
Source: Biological Trace Element Research - August 8, 2018 Category: Biology Authors: Król E, Bogdański P, Suliburska J, Krejpcio Z Tags: Biol Trace Elem Res Source Type: research

A Brief Overview from the Physiological and Detrimental Roles of Zinc Homeostasis via Zinc Transporters in the Heart.
Abstract Zinc (mostly as free/labile Zn2+) is an essential structural constituent of many proteins, including enzymes in cellular signaling pathways via functioning as an important signaling molecule in mammalian cells. In cardiomyocytes at resting condition, intracellular labile Zn2+ concentration ([Zn2+]i) is in the nanomolar range, whereas it can increase dramatically under pathological conditions, including hyperglycemia, but the mechanisms that affect its subcellular redistribution is not clear. Therefore, overall, very little is known about the precise mechanisms controlling the intracellular distribution of...
Source: Biological Trace Element Research - August 8, 2018 Category: Biology Authors: Turan B Tags: Biol Trace Elem Res Source Type: research

Investigation and Comparison of In Vitro Genotoxic Potency of PM10 Collected in Rural and Urban Sites at Tehran in Different Metrological Conditions and Different Seasons.
Abstract The particulate matter has become a serious health problem in some large cities in the world. These particles are a complex mixture of chemical compounds which change based on location and time and, consequently, can cause different health-related effects. The exact mechanism of the effect of these particles is not yet known for certain. However, it seems that numerous mechanisms through the production of ROS and, eventually, DNA destruction, which are related to a wide range of diseases, are among the causes of particles' health-related effects. The present study is aimed to evaluate and compare the geno...
Source: Biological Trace Element Research - August 3, 2018 Category: Biology Authors: Ghanbarian M, Nicknam MH, Mesdaghinia A, Yunesian M, Hassanvand MS, Soleimanifar N, Rezaei S, Atafar Z, Ghanbarian M, Faraji M, Ghozikali MG, Naddafi K Tags: Biol Trace Elem Res Source Type: research

The Screening of Nails for Selected Essential and Toxic Elements in Normotensive and Pre-Eclamptic Women.
Abstract To compare the concentrations of 13 different elements in nail samples from pre-eclamptic and normotensive pregnant women. The study site was a regional hospital in Durban, KwaZulu Natal. Nail samples were collected from normotensive (n = 33) and pre-eclamptic (n = 33) pregnant women. Approximately 0.02 g of nail samples were digested in 70% nitric acid and analyzed using inductively coupled plasma-optical emission spectrometry. Analytes of interest were the following essential elements calcium (Ca), chromium (Cr), cobalt (Co), copper (Cu), iron (Fe), magnesium (Mg), manganese...
Source: Biological Trace Element Research - August 2, 2018 Category: Biology Authors: Soobramoney C, Maduray K, Moodley J, Moodley R, Naicker T Tags: Biol Trace Elem Res Source Type: research

Zinc-Enriched Yeast Improves Learning and Memory Impairments in Zinc-Deficient Rats.
Abstract Zinc (Zn) highly concentrates in the brain and plays a key role in memory formation and learning processes. Zn deficiency results in cognitive impairments, memory deficits, alterations of neuropsychological behavior, and motor development. Although Zn-enriched yeast (ZnY) is widely used for dietary fortification and supplementation of Zn, the effect of ZnY on cognition still remains unclear. The purpose of the study was to investigate the effect of ZnY on behavior in Zn-deficient and Zn-sufficient rats. Three-week-old rats were fed low Zn diets for 145 days to establish Zn-deficient rats. ZnY was ora...
Source: Biological Trace Element Research - August 1, 2018 Category: Biology Authors: Zhang SQ, Zhang HB, Cheng Q, Zhu YM, Xia CH, Zhu YH, Zhang Y Tags: Biol Trace Elem Res Source Type: research

Serum and Seminal Plasma Element Concentrations in Relation to Semen Quality in Duroc Boars.
Abstract Element concentrations in serum and seminal plasma were studied in Duroc boars with different semen quality characteristics. Based on the utilization rate of 2174 ejaculates from June to August in 2016, a total of 166 Duroc boars were allocated into three groups: low utilization rate group (LG, 0 to 60% utilization rate), medium utilization rate group (MG, 60 to 80%), and high utilization rate group (HG, 80 to 100%). Serum and seminal plasma samples were collected, and element levels were analyzed using inductively coupled plasma mass spectrometry. The results showed that LG boars had higher concentration...
Source: Biological Trace Element Research - August 1, 2018 Category: Biology Authors: Wu YH, Lai W, Liu ZH, Wei HK, Zhou YF, Tan JJ, Sun HQ, Li SQ, Peng J Tags: Biol Trace Elem Res Source Type: research

Copper or Magnesium Supplementation Endows the Peptic Hydrolysate from Bovine Lactoferrin with Enhanced Activity to Human Gastric Cancer AGS Cells.
Abstract A lactoferrin hydrolysate (LFH) was generated from bovine lactoferrin by pepsin, mixed with Cu2+ and Mn2+ at 0.64-1.28 and 0.28-0.56 mg/g protein, respectively; and then their in vitro effects on human gastric cancer AGS cells were assessed. With incubation times of 24 or 48 h, LFH and its Cu2+/Mn2+ mixtures at 10-30 mg/mL in dose-dependent manner inhibited cell growth; and more, these mixtures showed higher activities than LFH alone. Cell treatments of LFH and the mixtures (25 mg/mL) for 24 h could arrest cell cycle at G0/G1-phase, damage mitochondrial membrane integrity, and ind...
Source: Biological Trace Element Research - August 1, 2018 Category: Biology Authors: Bo LY, Li TJ, Zhao XH Tags: Biol Trace Elem Res Source Type: research

Protective Effect of Hesperidin on Sodium Arsenite-Induced Nephrotoxicity and Hepatotoxicity in Rats.
In this study, it was seen that HSP showed a protective effect against SA-induced kidney and liver toxicity. PMID: 30066062 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - July 31, 2018 Category: Biology Authors: Turk E, Kandemir FM, Yildirim S, Caglayan C, Kucukler S, Kuzu M Tags: Biol Trace Elem Res Source Type: research

Is Lithium a Micronutrient? From Biological Activity and Epidemiological Observation to Food Fortification.
Abstract Lithium compounds have been widely used in psychopharmacology, particularly in the treatment of bipolar disorder. Their normothymic and neuroprotective properties when used at high doses have been well established. However, a number of observations suggest that environmentally relevant lithium doses may also exert beneficial health effects, leading to a decrease in the rate of suicides and levels of violence. Despite the fact that this element is not officially considered to be a micronutrient, some authors have suggested provisional recommended intakes set at 1000 μg/day for a 70-kg adult (14.3&n...
Source: Biological Trace Element Research - July 31, 2018 Category: Biology Authors: Szklarska D, Rzymski P Tags: Biol Trace Elem Res Source Type: research

Lead and Mercury Levels in Preterm Infants Before and After Blood Transfusions.
This study aimed to determine pre-/post-transfusion erythrocyte lead and mercury levels in infants and to correlate these levels to heavy metal concentrations in pRBCs. VLBW infants (n = 80), needing pRBC transfusion for the first time, were enrolled. Erythrocyte heavy metal levels were determined in pre-/post-transfusion blood samples and also in pRBC units. Mean lead and mercury levels in the pRBCs were found to be 16.3 ± 10.8 and 3.75 ± 3.23 μg/L, respectively. Of the infants, 69.7% received lead above reference dose. Erythrocyte lead levels increased signi...
Source: Biological Trace Element Research - July 31, 2018 Category: Biology Authors: Takci S, Asci A, Erkekoglu P, Yiğit S, Kocer-Gumusel B, Yurdakök M Tags: Biol Trace Elem Res Source Type: research

Sodium Fluoride (NaF) Induces Inflammatory Responses Via Activating MAPKs/NF- κB Signaling Pathway and Reducing Anti-inflammatory Cytokine Expression in the Mouse Liver.
This study aimed to investigate the mRNA and protein levels of inflammatory cytokines and signaling molecules for evaluating the effect of different doses (0, 12, 24, and 48 mg/kg) of sodium fluoride (NaF) on inflammatory reaction in the mouse liver by using methods of experimental pathology, quantitative real-time polymerase chain reaction (qRT-PCR), and western blot analysis. We found that NaF in excess of 12 mg/kg caused the hepatic inflammatory responses, and the results showed that NaF activated the mitogen-activated protein kinases (MAPKs) signaling pathway by markedly increasing (p 
Source: Biological Trace Element Research - July 30, 2018 Category: Biology Authors: Chen L, Kuang P, Liu H, Wei Q, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L Tags: Biol Trace Elem Res Source Type: research

Comparison of Inorganic and Organically Bound Trace Minerals on Tissue Mineral Deposition and Fecal Excretion in Broiler Breeders.
This study investigated the effects of replacement of inorganic trace minerals (ITMs) by organic trace minerals (OTMs) on tissue mineral retention and fecal excretion in "Zhen Ning" yellow feather broiler breeders. Six hundred hens (initial BW: 1.70 ± 0.07 kg) aged 40 weeks were randomly divided into five treatments, with four replicates of 30 broiler breeders each. Experimental treatments were as follows: (1) ITM (Cu, Zn, Fe, Mn, Se providing commercially recommended concentrations), (2) L-ITM (50% of the ITM, except for Se), (3) VL-OTM (37.5% of the ITM, except for Se), (4) L-OTM ...
Source: Biological Trace Element Research - July 30, 2018 Category: Biology Authors: Wang G, Liu L, Wang Z, Pei X, Tao W, Xiao Z, Liu B, Wang M, Lin G, Ao T Tags: Biol Trace Elem Res Source Type: research

The Effect of Urbanization on Trace Element Concentration and Symmetry of Woodlice (Armadillidium vulgare Latreille, 1804).
ute;rész B Abstract Woodlice are top consumers of a three-trophic system (soil, leaf litter, woodlice), and they are closely related to pollutant absorbing surfaces such as soil, leaf litter, and organic matter. We studied the effects of urbanization on trace element concentrations and fluctuating asymmetry of Armadillidium vulgare (Crustacea: Isopoda) individuals in and around Debrecen city, Hungary. Along an urbanization gradient (urban, suburban, and rural areas), trace element concentrations (Ba, Cu, Fe, Mn, Pb, and Zn) of woodlice and bioconcentration factor (BCF) were analyzed. Asymmetry was also meas...
Source: Biological Trace Element Research - July 28, 2018 Category: Biology Authors: Papp D, Simon E, Nagy L, Mizser S, Tóthmérész B Tags: Biol Trace Elem Res Source Type: research

Detection of Se, Vit. E, Vit. A, MDA, 8-OHdG, and CoQ10 Levels and Histopathological Changes in Heart Tissue in Sheep with White Muscle Disease.
This study was carried out to determine vit. E, Se, vit. A, malondialdehyde (MDA), 8-hydroxy-2-deoxyguanosine (8-OHdG), and ubiquinone-10 (CoQ10) levels and histopathological changes in sheep with white muscle disease (WMD). A total of 30 sheep were used; 20 sheep with WMD were brought to our clinic for diagnosis and treatment at various times, and 10 healthy sheep were in the control group. The Se, vit. E, vit. A, MDA, 8-OHdG, and CoQ10 values of the healthy and WMD sheep were as follows: 0.917 ± 0.037, 0.790 ± 0.067; 1.190 ± 0.011, 1.090 ±&thins...
Source: Biological Trace Element Research - July 27, 2018 Category: Biology Authors: Yildirim S, Ozkan C, Huyut Z, Çınar A Tags: Biol Trace Elem Res Source Type: research

Metal Biomonitoring and Comparative Assessment in Urine of Workers in Lead-Zinc and Steel-Iron Mining and Smelting.
Abstract The exposure of heavy metals (lead (Pb), cadmium (Cd), copper (Cu), nickel (Ni), and metalloid arsenicals) and their effects on workers' health from a lead-zinc mine (145 workers) and a steel smelting plant (162 workers) was investigated. Information on subject characteristics was obtained through a questionnaire. We determined the urinary levels of Pb, Cd, Cu, Ni, and arsenicals (including inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA), as were 8-hydroxydeoxyguanosine (8-OHdG) and cystatin C. Lead-zinc mine foundry workers had significantly higher concentrations of ...
Source: Biological Trace Element Research - July 27, 2018 Category: Biology Authors: Wang X, Jin P, Zhou Q, Liu S, Wang F, Xi S Tags: Biol Trace Elem Res Source Type: research

Arsenic-Induced Neurotoxicity by Dysfunctioning Cholinergic and Dopaminergic System in Brain of Developing Rats.
Abstract Chronic exposure to arsenic via drinking water throughout the globe is assumed to cause a developmental neurotoxicity. Here, we investigated the effect of perinatal arsenic exposure on the neurobehavioral and neurochemical changes in the corpus striatum, frontal cortex, and hippocampus that is critically involved in motor and cognition functions. In continuation of previous studies, this study demonstrates that perinatal exposures (GD6-PD21) to arsenic (2 or 4 mg/kg body weight, p.o.) cause hypo-activity in arsenic-exposed rats on PD22. The hypo-activity was found to be linked with a decrease in the ...
Source: Biological Trace Element Research - July 26, 2018 Category: Biology Authors: Chandravanshi LP, Gupta R, Shukla RK Tags: Biol Trace Elem Res Source Type: research

Serum Concentrations of Trace Elements Zinc, Copper, Selenium, and Manganese in Critically Ill Patients.
Abstract We measured serum concentrations of trace elements and evaluated their clinical significance in relation to treatment outcomes of critically ill patients. A total of 167 participants (105 men and 62 women; average age, 61.4 years; age range, 18-90 years) were enrolled. Arterial blood concentrations of the trace elements zinc, copper, selenium, and manganese were measured every 14 days. At the time of intensive care unit (ICU) admission, serum concentrations of zinc, selenium, copper, and manganese were lower than the normal values in 75.1, 1.8, 37.8, and 2.1% of patients, respectively. Seru...
Source: Biological Trace Element Research - July 25, 2018 Category: Biology Authors: Lee YH, Bang ES, Lee JH, Lee JD, Kang DR, Hong J, Lee JM Tags: Biol Trace Elem Res Source Type: research

Protective Effect of Nanoceria on Cisplatin-Induced Nephrotoxicity by Amelioration of Oxidative Stress and Pro-inflammatory Mechanisms.
Abstract Cisplatin (CP) is one of the most important anticancer compounds with its therapeutic usefulness in diverse types of solid cancer. However, its use is limited due to nephrotoxicity induced by it. Oxidative stress is an effective participant which contributes actively to pathogenesis of CP-induced nephrotoxicity. Nanoparticle form of a rare earth metal cerium, also known as nanoceria (NC), has come up as a potential antioxidant and anti-inflammatory agent. In the present study, administration of CP in Swiss mice resulted in reduction of body weight, increased oxidative stress and pro-inflammatory cytokine ...
Source: Biological Trace Element Research - July 25, 2018 Category: Biology Authors: Saifi MA, Sangomla S, Khurana A, Godugu C Tags: Biol Trace Elem Res Source Type: research

Trace Element Uptake and Accumulation in the Medicinal Herb Hypericum perforatum L. Across Different Geolithological Settings.
In this study, the concentrations of essential and non-essential trace elements-Co, Cr, Cu, Ni, Sr, and Zn-were determined in the roots and aerial parts of the worldwide distributed and economically important medicinal herb Hypericum perforatum L. (St. John's wort) and in its growing substrate. Most of the analyzed trace elements varied considerably in the plant parts according to edaphic conditions and soil geochemistry. However, uptake and retention in H. perforatum compartments of Co, Cr, and Ni, which markedly differentiated the investigated soils, were controlled by excluding mechanisms of the plant. Despite this, the...
Source: Biological Trace Element Research - July 25, 2018 Category: Biology Authors: Bonari G, Monaci F, Nannoni F, Angiolini C, Protano G Tags: Biol Trace Elem Res Source Type: research

Dispersed Solidified Fine Droplets Based on Sonication of a Low Melting Point Deep Eutectic Solvent: a Novel Concept for Fast and Efficient Determination of Cr(VI) in Urine Samples.
Abstract Cr(VI) has carcinogenic effects, so determination of trace amount of chromium in human body such as urine has a great deal of importance. In this work, a novel microextraction method was developed based on solidification of dispersed fine droplets (SDFD) of a low melting point deep eutectic solvent (DES), produced with the aid of sonication, for fast and efficient determination of Cr(VI) in urine samples. Cr(VI) contents of the human urine samples were first complexed using 1,5-diphenylcarbazone at pH ≈ 2.0 and then extracted by the method. A cloudy solution was achieved by the sonicat...
Source: Biological Trace Element Research - July 24, 2018 Category: Biology Authors: Seidi S, Alavi L, Jabbari A Tags: Biol Trace Elem Res Source Type: research

Differential Expression of miRNAs in the Hippocampi of Offspring Rats Exposed to Fluorine Combined with Aluminum during the Embryonic Stage and into Adulthood.
Abstract A previous study from our team found that continuous exposure to fluorine combined with aluminum (FA) impaired the neurobehavioral reflexes, spatial learning, and memory of offspring rats. To date, the specific mechanisms for these changes are unclear. Here, high-throughput sequencing was utilized to analyze the microRNA (miRNA) profile of the hippocampi in the offspring of rats exposed to FA during the embryonic stage and into adulthood through tap water supplemented with NaF and AlCl3 at concentrations of (0, 0); (60, 600); (120, 600); and (240, 600) mg/L, respectively. qRT-PCR was performed to val...
Source: Biological Trace Element Research - July 22, 2018 Category: Biology Authors: Ge QD, Xie C, Zhang H, Tan Y, Wan CW, Wang WJ, Jin TX Tags: Biol Trace Elem Res Source Type: research

Effect of Different Sources of Supplemental Zinc on Performance, Nutrient Digestibility, and Antioxidant Enzyme Activities in Lambs.
Abstract Zinc (Zn) is an essential element in the growth of all animals and plays structural and catalytic roles in many enzymes and functional proteins. Two completely randomized trials were conducted to evaluate the effects of different sources of zinc on performance, nutrient digestibility, blood mineral profile, and antioxidant enzyme activities in male growing lambs on a barley-based diet. The first trial was conducted for 70 days and consisted of 30 lambs (30.8 ± 2.8 kg mean body weight, 4-5 months of age) which were randomly allocated to five treatments consisting of a ba...
Source: Biological Trace Element Research - July 21, 2018 Category: Biology Authors: Alimohamady R, Aliarabi H, Bruckmaier RM, Christensen RG Tags: Biol Trace Elem Res Source Type: research

Study of Bioaccumulation, Hematological Parameters, and Antioxidant Responses of Carassius auratus gibelio Exposed to Dietary Lead and Bacillus subtilis.
Abstract Lead (Pb) is one of the most ubiquitous and toxic elements in the aquatic environment. Bacillus subtilis (B. subtilis) is a widely used probiotic in aquaculture. The aim of this study was to explore the toxic effects on bioaccumulation, hematological parameters, and antioxidant responses of Carassius auratus gibelio (C. gibelio) exposed to dietary lead at 0, 120, and 240 mg/kg and/or B. subtilis at 109 cfu/g. At 15 and 30 days, the fish were sampled and bioaccumulation, hematological parameters, and antioxidant responses were assessed. The result showed that B. subtilis administration can p...
Source: Biological Trace Element Research - July 21, 2018 Category: Biology Authors: Yin Y, Yue X, Zhang D, Zhang P, Abdallah A, Yin Y, Cai Y, Li Y Tags: Biol Trace Elem Res Source Type: research

Determination of Trace Elements in Adipose Tissue of Obese People by Microwave-Assisted Digestion and Inductively Coupled Plasma Optical Emission Spectrometry.
Abstract In the present work, analytical method for the determination of trace elements in adipose tissue by means of inductively coupled plasma optical emission spectrometry (ICP-OES) was developed. Adipose tissue from two groups of the patients with obesity (with and without metabolic syndrome) was investigated. The main aim of this study was to reveal some differences and regularities in concentrations of trace elements in adipose tissue between these two groups of the individuals. Moreover, different types of adipose tissue (subcutaneous, preperitoneal, and visceral) were analyzed separately in order to invest...
Source: Biological Trace Element Research - July 21, 2018 Category: Biology Authors: Kizalaite A, Brimiene V, Brimas G, Kiuberis J, Tautkus S, Zarkov A, Kareiva A Tags: Biol Trace Elem Res Source Type: research

Dietary Iron Modulates Glucose and Lipid Homeostasis in Diabetic Mice.
Abstract Imbalance of iron homeostasis has been involved in clinical courses of metabolic diseases such as type 2 diabetes mellitus, obesity, and nonalcoholic fatty liver, through mechanisms not yet fully elucidated. Herein, we evaluated the effect of dietary iron on the development of diabetic syndromes in genetically obese db/db mice. Mice (aged 7 weeks) were fed with high-iron (HI) diets (1000 mg/kg chow) or low-iron (LI) diets (12 mg/kg) for 9 weeks. HI diets increased hepatic iron threefold and led to fourfold higher mRNA levels of hepcidin. HI also induced a 60% increase in fasting glucos...
Source: Biological Trace Element Research - July 19, 2018 Category: Biology Authors: Ma W, Feng Y, Jia L, Li S, Li J, Wang Z, Chen X, Du H Tags: Biol Trace Elem Res Source Type: research

Zinc Chelator Inhibits Zinc-Induced Islet Amyloid Polypeptide Deposition and Apoptosis in INS-1 Cells.
In this study, we aimed to investigate whether chelating zinc could inhibit zinc-induced amyloid deposits and apoptosis of islet beta cell. N, N, N', N'-Tetrakis (2-pyridylmethyl) ethylenediamine (TPEN) is a specific chelator of zinc, with membrane permeability. It could effectively reduce the concentration of intracellular zinc. So, we used TPEN to treat hIAPP-transfected INS-1 cells. By MTT assay, the concentration (1 μM) and incubation time (12 h) of TPEN without affecting cell viability were determined. The results showed that TPEN reduced zinc-induced IAPP deposition in the culture system. Furthermore, we...
Source: Biological Trace Element Research - July 19, 2018 Category: Biology Authors: Tian H, Wang ZY Tags: Biol Trace Elem Res Source Type: research

Iron Deficiency Reduces Synapse Formation in the Drosophila Clock Circuit.
Abstract Iron serves as a critical cofactor for proteins involved in a host of biological processes. In most animals, dietary iron is absorbed in enterocytes and then disseminated for use in other tissues in the body. The brain is particularly dependent on iron. Altered iron status correlates with disorders ranging from cognitive dysfunction to disruptions in circadian activity. The exact role iron plays in producing these neurological defects, however, remains unclear. Invertebrates provide an attractive model to study the effects of iron on neuronal development since many of the genes involved in iron metabolism...
Source: Biological Trace Element Research - July 18, 2018 Category: Biology Authors: Rudisill SS, Martin BR, Mankowski KM, Tessier CR Tags: Biol Trace Elem Res Source Type: research

Health Risk Assessment for Human Exposure to Trace Metals and Arsenic via Consumption of Hen Egg Collected from Largest Poultry Industry in Iran.
Abstract The relative contribution of foodstuffs to intake of heavy metal is still equivocal, and thus, available data are rare. Here, the concentration of ten heavy metals and arsenic were measured in the content of hen egg from five strains of commercial laying hens to evaluate contamination level and potential health risk among local and international consumers in Iran. The estimated daily intake (EDI) of all heavy metals was significantly lower than the provisional tolerable daily intake (PTDI) and respective tolerable daily intake (TDI). The non-carcinogenic and carcinogenic risk values for eating eggs were i...
Source: Biological Trace Element Research - July 17, 2018 Category: Biology Authors: Hashemi M, Sadeghi A, Saghi M, Aminzare M, Raeisi M, Rezayi M, Sany SBT Tags: Biol Trace Elem Res Source Type: research

Assessing Essential Trace Elements in Cave Nectar Bat (Eonycteris spelaea): A Study in Barak Valley of Assam, India.
This study investigated trace elements in the different organs of Eonycteris spelaea, a hill cave from the Bhuban Hills of Sonai Reserve Forest, Cachar, Assam (India). Six bats were collected from the site and concentrations of four trace elements (Cu, Zn, Fe, and Mn) were examined from the tissues of liver, lungs, kidney, and patagium using graphite furnace atomic absorption spectrometer (graphite furnace model-Analytic Jena Vario-6). The results of the study revealed that concentration of essential trace elements in the body tissues of E. spelaea were less than the maximum permissible limit. During the study, it was foun...
Source: Biological Trace Element Research - July 17, 2018 Category: Biology Authors: Rahman A, Choudhury P, Talukdar NR Tags: Biol Trace Elem Res Source Type: research

Sources and Levels of Trace Elements Influence Some Blood Parameters in Murrah Buffalo (Bubalus bubalis) Calves.
Abstract Sources of supplemental minerals in the diet of animals are of important significance. Bio-availability of organic sources is believed to be more in the body as compared to regularly used inorganic sources and hence environment-friendly due to reduced mineral excretion, which in turn reduces their requirements in the diet as well. Twenty-four male Murrah buffalo (Bubalus bubalis) calves (about 18-20 months of age and 318.54 ± 8.85 kg body weight) were divided randomly into four groups of six animals each. In the control group (C, InOrg100) zinc (Zn), copper (Cu), and mangane...
Source: Biological Trace Element Research - July 16, 2018 Category: Biology Authors: Mudgal V, Saxena N, Kumar K, Dahiya SS, Punia BS, Sharma ML Tags: Biol Trace Elem Res Source Type: research

The Effect of Zinc Sulfate on miR-122, miR-34a, Atioxidants, Biochemical and Histopathological Parameters Following Hepatic Ischemia/Reperfusion Injury in Rats.
Abstract Liver ischemia-reperfusion (IR) injury is a situation which occurs in various conditions such as pringle maneuver and liver transplantation. The regulatory effect of zinc sulfate (ZnSO4) is an important trace element on several liver disorders well known, but its effects on microRNAS (miR-122 and miR-34a) have not been evaluated. The goal of this study was to identify the protective effects of ZnSO4 on IR-induced liver injury, in particular, microRNAS in rats. Thirty-two male Wistar rats were randomly assigned into four groups (eight each group): sham, IR, ZnSO4 pretreatment, and ZnSO4 + IR groups. In sha...
Source: Biological Trace Element Research - July 16, 2018 Category: Biology Authors: Mard SA, Akbari G, Dianat M, Mansouri E Tags: Biol Trace Elem Res Source Type: research

Genistein and Silicon Synergistically Protects Against Ovariectomy-Induced Bone Loss Through Upregulating OPG/RANKL Ratio.
This study was performed to evaluate the bone protective mechanisms of concomitant intake of genistein and silicon in ovariectomized rat by OPG/RANKL axis. Three-month-old Sprague-Dawley female rats were subjected to ovariectomy (OVX) or sham surgery; after surgery, the OVX rats were randomly divided into five groups: OVX-Gen, OVX-Si, OVX-Gen-Si, OVX-E, and OVX. Genistein, silicon, and 17β-estradiol supplementation were started after ovariectomy and continued for 10 weeks. The results showed that genistein and silicon treatment increased the bone mineral density (BMD) of ovariectomized rats. In addition, the BMD ...
Source: Biological Trace Element Research - July 16, 2018 Category: Biology Authors: Chen C, Zheng H, Qi S Tags: Biol Trace Elem Res Source Type: research

Evaluation of Plasma Trace Elements in Different Stages of Nonalcoholic Fatty Liver Disease.
Abstract Nonalcoholic fatty liver disease (NAFLD) is considered as the hepatic manifestation of metabolic syndrome. Its global prevalence is estimated between 25 and 45%, occurring mainly in overweight individuals with unhealthy dietary habits and low levels of physical activity. Many studies have investigated the association of trace elements with liver diseases, though not with NAFLD. In this work, we investigated trace element levels in plasma of patients and not-patients and their possible association with various stages of the disease. Inductively coupled plasma mass spectrometry (ICP-MS) was employed for the...
Source: Biological Trace Element Research - July 16, 2018 Category: Biology Authors: Asprouli E, Kalafati I, Sakellari A, Karavoltsos S, Vlachogiannakos J, Revenas K, Kokkinos A, Dassenakis M, Dedoussis GV, Kalogeropoulos N Tags: Biol Trace Elem Res Source Type: research

Calculation of an Adequate Intake (AI) Value and Safe Range of Selenium (Se) for Chinese Infants 0-3  Months Old Based on Se Concentration in the Milk of Lactating Chinese Women with Optimal Se Intake.
This study assessed the current selenium nutritional status of 264 lactating Chinese women from three geographical locations with different Se levels (Liangshan in Sichuan province, Enshi in Hubei province, and Xicheng District in Beijing), to screen mothers with optimal Se intake, and to modify the AI value of Se for Chinese infants 0-3 months old. Milk and plasma Se concentrations were determined by inductively coupled plasma mass spectrometry (ICP-MS) and glutathione peroxidase 3 (GPx3), and plasma selenoprotein P (SEPP1) was measured by ELISA. Daily Se intake (Y, μg/day) in lactating Chinese woman was calculate...
Source: Biological Trace Element Research - July 16, 2018 Category: Biology Authors: Han F, Liu L, Lu J, Chai Y, Zhang J, Wang S, Sun L, Wang Q, Liu Y, He M, Mu W, Huang Z Tags: Biol Trace Elem Res Source Type: research

Prevalence and Factors Associated with High Levels of Aluminum, Arsenic, Cadmium, Lead, and Mercury in Hair Samples of Well-Nourished Thai Children in Bangkok and Perimeters.
Abstract Toxic element exposure increases risk of neurodevelopmental disorders. However, hair element profiles of well-nourished urban resident children were largely unknown. We identified prevalence and the contributing factors of high hair aluminum (Al), arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg) levels in 111 Thai children (aged 3-7 years old). Most participants were well-nourished with high socioeconomic status. Since ROC curve of hair element data showed inadequate sensitivity for cutoff set-up, US reference hair levels were used to categorize high and low level groups. Nevertheless, compare...
Source: Biological Trace Element Research - July 13, 2018 Category: Biology Authors: Tippairote T, Temviriyanukul P, Benjapong W, Trachootham D Tags: Biol Trace Elem Res Source Type: research

Effects of Different Forms and Levels of Selenomethionine on Productive Performance and Antioxidant Status of Broiler Breeders and Its Offspring.
This study was conducted to investigate the effects of different selenomethionine (SM) forms and levels on productive performance and antioxidant status of broiler breeders and its offspring. Four hundred eighty 48-week-old Lingnan Yellow broiler breeders were randomly divided into four groups, provided basal diet with 0.15 or 0.30 mg/kg Se coming from two SM forms of DL-SM and L-SM. The experiment included a 4-week pretreatment period and an 8-week trial period. During the trial period, eggs were incubated once a week under standard conditions. The broiler breeders were slaughtered after the trial period. At the same...
Source: Biological Trace Element Research - July 9, 2018 Category: Biology Authors: Zhao R, Li K, Wang J, Wang Y, Wu R, Zhan X Tags: Biol Trace Elem Res Source Type: research

The Resveratrol Alleviates the Hepatic Toxicity of CuSO4 in the Rat.
Abstract Cu is toxic to humans and other animals. Oxidative stress is an important mechanism involved in Cu toxicity. Resveratrol (RSV) is an antioxidative compound, so could counteract Cu toxicity. The aim of this study was to determine whether RSV protects the liver from the effects of CuSO4. Forty male Sprague-Dawley rats (5 weeks old, 110-120 g) were divided into four groups (n = 10 per group), a control group and groups treated with CuSO4 at a dose of 200 mg/kg body weight (BW), RSV at a dose of 15 mg/kg BW, and CuSO4 at a dose of 200 mg/kg BW and RSV at a dose of 15&nbs...
Source: Biological Trace Element Research - July 6, 2018 Category: Biology Authors: Tian Y, Wu B, Li X, Jin X, Zhang F, Jiang C, Xu W, Li H, Wang H Tags: Biol Trace Elem Res Source Type: research

Suppressive Role of Boron on Adipogenic Differentiation and Fat Deposition in Human Mesenchymal Stem Cells.
In this report, a striking suppressive activity of boron on adipogenic differentiation of hADSCs is observed in a dose-dependent manner. Higher concentrations of NaB (20, 50, and 100 μg/mL (68, 170 and 340 μM)) resulted in a progressive decrease of lipid deposition, suppressed master regulators of adipogenesis transcriptional programming at the mRNA and protein levels, while having no evident cytotoxicity on the cells. The findings of this study are encouraging to undertake further investigations on potential beneficial effects boron in terms of its impact on normal and dysfunctional adipose biology. In tha...
Source: Biological Trace Element Research - July 6, 2018 Category: Biology Authors: Abdik EA, Abdik H, Taşlı PN, Deniz AAH, Şahin F Tags: Biol Trace Elem Res Source Type: research

Copper-Mediated Mitochondrial Fission/Fusion Is Associated with Intrinsic Apoptosis and Autophagy in the Testis Tissues of Chicken.
In conclusion, CuSO4 exposure can influence the mitochondrial dynamics balance and lead to mitochondria-initiated intrinsic pathway of apoptosis and autophagy, which triggers the testicular poisoning in chickens. What is more, there is a correlation among mitochondrial dynamics, apoptosis, and autophagy. PMID: 29974384 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - July 4, 2018 Category: Biology Authors: Shao Y, Zhao H, Wang Y, Liu J, Zong H, Xing M Tags: Biol Trace Elem Res Source Type: research

Health Effects of Trace Metals in Electronic Cigarette Aerosols-a Systematic Review.
Abstract Electronic cigarettes (ECs) are essentially nicotine delivery devices that mimic the appearance of a conventional cigarette (CC). Lately, they have been marketed as tools for quitting smoking. Even though they are promoted as safe alternatives to CC, they are not devoid of hazardous components. Literature reveals that the EC aerosols and e-liquids are a potential source of elements that induce and promote development of chronic conditions. These include trace metals which are leached from their core assembly. Some of these metals like nickel, chromium, cadmium, tin, aluminum, and lead are potential carcin...
Source: Biological Trace Element Research - July 4, 2018 Category: Biology Authors: Gaur S, Agnihotri R Tags: Biol Trace Elem Res Source Type: research

Effect of Vanadium Supplementation on Production Performance, Nutrient Utilization, Plasma Mineral Concentration, and Mineral Balance in Lactating Goats.
The objective of this study was to determine the effect of V supplementation on production performance, milk composition, and mineral profile in lactating goats. Twenty-four crossbred goats (body weight 34.83 ± 0.25 kg) were blocked in four groups and randomly assigned to four treatment groups (n = 6) on body weight and milk yield basis. All the animals were kept on similar feeding regimen except that different treatment groups were supplemented with 0, 2, 4, and 6 ppm inorganic V/kg DM. Feed intake, milk yield, milk composition, nutrient utilization, minerals in plasma and milk, ...
Source: Biological Trace Element Research - July 3, 2018 Category: Biology Authors: Tripathi D, Mani V, Pal RP Tags: Biol Trace Elem Res Source Type: research

Levels of Essential and Xenobiotic Elements and Their Relationships in Milk Available on the Slovak Market with the Estimation of Consumer Exposure.
Abstract The monitoring of various elements in the cow milk is important in the agricultural sector. The goal of this study was to determine the concentrations of calcium (Ca), cadmium (Cd), copper (Cu), iron (Fe), mercury (Hg), potassium (K), magnesium (Mg), sodium (Na), nickel (Ni), lead (Pb), and zinc (Zn) in the milk samples coming from different origins (local region in Nitra, nationwide sample represents the common Slovak brands of milk and common brands of milk from Czech Republic widely available in Slovakia). The samples were analyzed using atomic absorption spectrometry. A high level of variability in th...
Source: Biological Trace Element Research - July 3, 2018 Category: Biology Authors: Capcarova M, Binkowski LJ, Stawarz R, Schwarczova L, Massanyi P Tags: Biol Trace Elem Res Source Type: research

Trace Metals in the Freshwater Fish Cyprinus carpio: Effect to Serum Biochemistry and Oxidative Status Markers.
Abstract Interactions between trace metals, serum biochemical parameters, and oxidative status markers were observed. Freshwater fish Cyprinus carpio blood samples (n = 38) were collected at the beginning of May (n = 19) and at the end of July (n = 19) of 2015. The concentrations of metals (As, Cd, Cr, Cu, Fe, Mn, Ni, Pb, Se, Sr, and Zn) were analyzed in blood serum samples of fishes by inductively coupled plasma optical emission spectrometry (ICP-OES), and Hg was determined by cold-vapor atomic absorption spectroscopy (CV-AAS). The general scheme of descending concentrati...
Source: Biological Trace Element Research - July 2, 2018 Category: Biology Authors: Kovacik A, Tvrda E, Miskeje M, Arvay J, Tomka M, Zbynovska K, Andreji J, Hleba L, Kovacikova E, Fik M, Cupka P, Nahacky J, Massanyi P Tags: Biol Trace Elem Res Source Type: research

Is There Any Role of Arsenic Toxicity in HPV Related Oral Squamous Cell Carcinoma?
Abstract Arsenic is a potent human carcinogen affecting the rate of cancer deaths worldwide. In India, West Bengal is the worst affected state by arsenic. To our best knowledge, this is the first study relating arsenic toxicity with oral carcinoma, along with HPV infection, the latter being well established in western countries. To find out a possible correlation between arsenic toxicity and oral carcinoma in the population of West Bengal, in or without any association with human papilloma virus infection. Ethical clearance of this study was obtained from the institutional committee. One hundred and four malignant...
Source: Biological Trace Element Research - June 29, 2018 Category: Biology Authors: Pal P, Halder A Tags: Biol Trace Elem Res Source Type: research

Assessment of the Health Risk Induced by Accumulated Heavy Metals from Anaerobic Digestion of Biological Sludge of the Lettuce.
This study showed that application of anaerobically digested sludge can increase the bioaccumulation rate of heavy metals in the crops and induce more human health risk. PMID: 29959646 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - June 29, 2018 Category: Biology Authors: Shamsollahi HR, Alimohammadi M, Momeni S, Naddafi K, Nabizadeh R, Khorasgani FC, Masinaei M, Yousefi M Tags: Biol Trace Elem Res Source Type: research

Human Sperm Characteristics with Regard to Cobalt, Chromium, and Lead in Semen and Activity of Catalase in Seminal Plasma.
We examined relationships and differences between Co, Cr, and Pb concentrations in seminal plasma, CAT activity, and semen parameters. We did not establish differences in Co, Cr, and Pb concentrations and CAT activity from men between normozoospermic and those with pathological spermiogram. We found a significantly lower Co concentration and CAT activity in males with normal sperm motility than in asthenozoospermic males. We found significantly lower Co and a higher Pb concentration in males with normal morphology of spermatozoa than in teratozoospermic males. We found a significantly higher Pb concentration in the individ...
Source: Biological Trace Element Research - June 29, 2018 Category: Biology Authors: Marzec-Wróblewska U, Kamiński P, Łakota P, Szymański M, Wasilow K, Ludwikowski G, Jerzak L, Stuczyński T, Woźniak A, Buciński A Tags: Biol Trace Elem Res Source Type: research