SARS-CoV-2: an imperative maternal-fetal concern
Iran J Microbiol. 2021 Aug;13(4):427-433. doi: 10.18502/ijm.v13i4.6963.ABSTRACTSevere acute respiratory syndrome corona virus 2 (SARS-CoV-2) is a newly emerged virus which belongs to Coronaviridae family within the betacoronavirus genus. Previous reports demonstrated that other betacoronaviruses were responsible for adverse outcomes during pregnancy in human. Due to inadequate data, the consequences of a SARS-CoV-2 infection during pregnancy is still a public health concern in the second year of SARS-CoV-2 circulation in human population. Herein, we aimed to review the probable risk of intrauterine vertical transmission of...
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Zahra Heydarifard Jila Yavarian Somayeh Shatizadeh Malekshahi Sevrin Zadheidar Talat Mokhtari-Azad Nazanin Zahra Shafiei-Jandaghi Source Type: research

Astaxanthin protective barrier and its ability to improve the health in patients with COVID-19
Iran J Microbiol. 2021 Aug;13(4):434-441. doi: 10.18502/ijm.v13i4.6965.ABSTRACTInflammation acts like a double-edged sword and can be harmful if not appropriately controlled. COVID-19 is created through a novel species of coronavirus SARS-CoV-2 (2019-nCoV). Elevated levels of inflammatory factors such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), etc. lead to Acute Respiratory Distress Syndrome (ARDS) and severe complications of infection in the lungs of coronavirus-infected patients. Astaxanthin is a natural and potent carotenoid with powerful antioxidant activity as well as an anti-inflammatory agen...
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Ali-Reza Ahmadi Roya Ayazi-Nasrabadi Source Type: research

Evaluation of < em > in vitro < /em > activity of ceftaroline on methicillin resistant < em > Staphylococcus aureus < /em > blood isolates from Iran
CONCLUSION: While resistance to CPT was not detected we found increased CPT MICs in 7.69% of MRSA isolates. Reduced susceptibility to CPT in the absence of mecA mutations is indicative of contribution of secondary chromosomal mutations in resistance development.PMID:34557271 | PMC:PMC8421581 | DOI:10.18502/ijm.v13i4.6967 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Negin Abdizadeh Mehri Haeili Hossein Samadi Kafil Amin Ahmadi Mohammad Mehdi Feizabadi Source Type: research

Genotypic and phenotypic characterization of < em > Streptococcus mutans < /em > strains isolated from patients with dental caries
This study evaluated the genotypic and phenotypic diversity of 209 S. mutans strains isolated from 336 patients with dental caries and compared with the universal reference strain, UA159.MATERIALS AND METHODS: Selective cultivation on mitis-salivaries-bacitracin agar and species-specific polymerase chain reaction (PCR) was carried out to isolate and identify the 209 S. mutans isolates from 336 patients with dental caries. Arbitrarily primed polymerase chain reaction (AP-PCR), PCR amplification of specific gene, acid production and biofilm formation capacity were performed to evaluate the genotypic and phenotypic variation....
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Mohammad Shahadat Hossain Sadab Alam Yead Morshed Nibir Tahrima Arman Tusty Sayyeed Mahmud Bulbul Mirajul Islam Mohammad Shahnoor Hossain Source Type: research

Biofilm formation and molecular analysis of intercellular adhesion gene cluster < em > (icaABCD) < /em > among < em > Staphylococcus aureus < /em > strains isolated from children with adenoiditis
CONCLUSION: Our findings indicated that icaABCD operon are associated with biofilm formation in S. aureus isolates, however the absence of these genes may not necessarily exclude this property.PMID:34557273 | PMC:PMC8421587 | DOI:10.18502/ijm.v13i4.6969 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Rasoul Ghaioumy Fatemehalsadat Tabatabaeifar Karamat Mozafarinia Aliasghar Arabi Mianroodi Elham Isaei Jos é Rubén Morones-Ramírez Setareh Agha Kuchak Afshari Davood Kalantar-Neyestanaki Source Type: research

Use of a new multiplex quantitative polymerase chain reaction based assay for simultaneous detection of < em > Neisseria meningitidis, Escherichia coli K < sub > 1 < /sub > < /em > , < em > Streptococcus agalactiae < /em > , and < em > Streptococcus pneumoniae < /em >
CONCLUSION: The remarkable benefit of this method is associated with the speed (up to 3 hours) at which the procedure could be completed. It is also worth noting that this method can reduce the personnel unintentional errors which may occur in the laboratory. On the other hand, as this method simultaneously identifies four common factors that cause bacterial meningitis, it could be used as an auxiliary method diagnostic technique in laboratories particularly in cases of emergency medicine.PMID:34557274 | PMC:PMC8421586 | DOI:10.18502/ijm.v13i4.6970 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Nastaran Hemmati Farhad Nikkhahi Amir Javadi Sahar Eskandarion Seyed Mahmoud Amin Marashi Source Type: research

High prevalence of multidrug-resistant non-fermentative Gram-negative bacilli harboring < em > bla < /em > < sub > IMP-1 < /sub > and < em > bla < /em > < sub > VIM-1 < /sub > metallo-beta-lactamase genes in Birjand, south-east Iran
Iran J Microbiol. 2021 Aug;13(4):470-479. doi: 10.18502/ijm.v13i4.6971.ABSTRACTBACKGROUND AND OBJECTIVES: Non-fermentative Gram-negative Bacilli (NFGNB) is known as a major cause of healthcare-associated infections with high levels of antibiotic resistance. The aim of this study was to investigate the antibiotic resistance profiles and molecular characteristics of metallo-beta-lactamase (MBL)-producing NFGNB.MATERIALS AND METHODS: In this cross-sectional study, the antibiotic resistance profile of 122 clinical NFGNB isolates was determined by the Kirby-Bauer disk diffusion and microdilution broth methods. Bacterial isolate...
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Mohammad Hasan Namaei Masoud Yousefi Parvin Askari Babak Roshanravan Ali Hashemi Yasaman Rezaei Source Type: research

Phylogenetic and molecular analysis based on genes 16S-rRNA, OMPA and POMP to identify < em > Chlamydia abortus < /em > infection occurrence at the milk samples of goats and sheep in west Azerbaijan of Iran
CONCLUSION: Phylogenetic analysis based on the gene of helicase showed that most of the isolates shared similarity> 99.97%.PMID:34557276 | PMC:PMC8421589 | DOI:10.18502/ijm.v13i4.6972 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Fariba Taheri Abdulghaffar Ownagh Karim Mardani Source Type: research

Role of biofilms in the survival of < em > Legionella pneumophila < /em > to sodium chloride treatment
CONCLUSION: Results from this study demonstrate that the sodium chloride disinfection strategy was effective on Legionella pneumophila planktonic cells but not on biofilms, which demonstrate the role of biofilms in the persistence and recolonization of L. pneumophila in water distribution systems.PMID:34557277 | PMC:PMC8421579 | DOI:10.18502/ijm.v13i4.6973 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Abdelwahid Assaidi Mostafa Ellouali Hassan Latrache Hafida Zahir El Mostafa Mliji Source Type: research

Mediastinal lymphadenopathy and prognosis of COVID-19 disease
This study aimed to investigate the mediastinal lymphadenopathy and the disease progression in COVID-19 patients.MATERIALS AND METHODS: In this case-control study, 195 COVID-19 patients were divided into two groups, with the mediastinal lymphadenopathy and without it. In these groups, demographic characteristics, underlying diseases, laboratory results, and outcomes were compared.RESULTS: The median age in the LAP group was higher than the opposite group (62 vs. 58.5; p= 0.037). SpO2 (85% vs. 90%; P
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Sanaz Pilechian Ali Pirsalehi Abolfazl Arabkoohi Source Type: research

First seroepidemiological investigation of human enterovirus 71 in Iran
This study, the first of this kind in Iran, aimed to find neutralizing antibodies against EV-A71 in serum of healthy individuals in different age groups based on neutralization test (NT).MATERIALS AND METHODS: In this cross-sectional study, 547 serum samples were collected from healthy individuals who were referring for routine checkup tests (aged from under 6 months to over 31 years old) to Imam-Khomeini Hospital in Tehran during January-December 2015. Serum samples were examined by NT in cell culture to detect neutralizing antibodies against EV-A71. In the next step, some of the positive samples were subjected to complet...
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Mahsa Javadi Ahmad Nejati Maryam Yousefi Mahmood Mahmoodi Zabihollah Shoja Shohreh Shahmahmoodi Source Type: research

Molecular epidemiology and phylogenetic analysis of human T-lymphotropic virus type 1 in the < em > tax < /em > gene and it association with adult t-cell leukemia/lymphoma disorders
CONCLUSION: Through phylogenetic and phylodynamic analyses HTLV-1 strain in Tehran were characterized in Iran. The appearance of HTLV-1 in Iran was probably happened by the ancient Silk Road which linked China to Antioch.PMID:34557280 | PMC:PMC8421578 | DOI:10.18502/ijm.v13i4.6976 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Samira Pourrezaei Shahrzad Shadabi Maryam Gheidishahran Abbas Rahimiforoushani Masoume Akhbari Mahnaz Tavakoli Mahshid Safavi Mobina Madihi Mehdi Norouzi Source Type: research

The mycological and molecular study of < em > Pneumocystis jiroveci < /em > pneumonia among HIV and non-HIV immunocompromised patients hospitalized in pulmonary units in Guilan, Northern Iran
CONCLUSION: Since PJP often causes symptoms that are similar to other illnesses, such as the flu or tuberculosis, clinical and laboratory findings should be used simultaneously for making the final decision on drug administration.PMID:34557281 | PMC:PMC8421585 | DOI:10.18502/ijm.v13i4.6977 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Zahra Rafat Keyhan Ashrafi Seyed Jamal Hashemi Elahe Sasani Alireza Naserani Hasti Kamali Sarvestani Farshid Hashemi Source Type: research

< em > CSU52 < /em > , a novel regulator functions as a repressor of L-sorbose utilization in < em > Candida albicans < /em >
CONCLUSION: This finding completes the identification of regulators in SUR1 pathway. This result paves the way to study the underlying molecular mechanisms of SOU1 gene regulation that in-turn helps to understand stress induced aneuploidy.PMID:34557282 | PMC:PMC8421577 | DOI:10.18502/ijm.v13i4.6978 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Dileep Pullepu Wasim Uddin Aswathy Narayanan M Anaul Kabir Source Type: research

Antibacterial activity of endosymbiotic bacterial compound from < em > Pheretima < /em > sp. earthworms inhibit the growth of < em > Salmonella < /em > Typhi and < em > Staphylococcus aureus < /em > : < em > in vitro < /em > and < em > in silico < /em > approach
CONCLUSION: Ten active compounds of endosymbiont bacteria, Cyclo (phenylalanyl-prolyl) and sedanolide were potential candidates for antibacterial compounds based on the inhibition test of the agar diffusion method and the results of reverse docking and Way2Drugs PASS.PMID:34557283 | PMC:PMC8421580 | DOI:10.18502/ijm.v13i4.6981 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Dirayah Rauf Husain Riuh Wardhani Source Type: research

Evaluation of cold atmospheric-pressure plasma against burn wound infections and gene silencing
CONCLUSION: Cold plasma showed pathogen inhibitory properties of P. aeruginosa and virulence alkaline protease and wound healing properties in animal models, so this inexpensive and suitable method can be presented to the medical community to disinfect burn wounds and improve wound healing.PMID:34557284 | PMC:PMC8421582 | DOI:10.18502/ijm.v13i4.6982 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Ensieh Abbasi Jalil Fallah Mehrabadi Mohamadreza Nourani Yasaman Nazar Namini Siamak Mohammadi Davoud Esmaeili Asieh Abbasi Source Type: research

Crude sulfated polysaccharides extracted from marine cyanobacterium < em > Oscillatoria simplicissima < /em > with evaluation antioxidant and cytotoxic activities
CONCLUSION: Microalgal polysaccharides have great therapeutically potential in drug development used as antitumor and antioxidant agents in near future.PMID:34557285 | PMC:PMC8421576 | DOI:10.18502/ijm.v13i4.6983 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Reham G Elkomy Mona M Ismail Source Type: research

Molecular characterization of healthcare and community-associated methicillin-resistant < em > Staphylococcus aureus < /em > using phage open-reading frame typing
Iran J Microbiol. 2021 Aug;13(4):560-564. doi: 10.18502/ijm.v13i4.6985.ABSTRACTThe polymerase chain reaction-based open reading frame typing (POT) method is a simple and rapid method for the strain-level discrimination of methicillin-resistant Staphylococcus aureus (MRSA). We investigated the molecular characteristics of S. aureus strains by multilocus sequencing typing (MLST) and POT and the profiles of antibiotic resistance and virulence genes of MRSA isolates in a single center of Tokyo, Japan. Five types by MLST and 19 types by POT were detected in the 25 MRSA isolates. ST5 and a POT1 score of 93 were associated with h...
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Takaaki Konuma Shunsuke Takahashi Masato Suzuki Arinobu Tojo Source Type: research

SARS-CoV-2: an imperative maternal-fetal concern
Iran J Microbiol. 2021 Aug;13(4):427-433. doi: 10.18502/ijm.v13i4.6963.ABSTRACTSevere acute respiratory syndrome corona virus 2 (SARS-CoV-2) is a newly emerged virus which belongs to Coronaviridae family within the betacoronavirus genus. Previous reports demonstrated that other betacoronaviruses were responsible for adverse outcomes during pregnancy in human. Due to inadequate data, the consequences of a SARS-CoV-2 infection during pregnancy is still a public health concern in the second year of SARS-CoV-2 circulation in human population. Herein, we aimed to review the probable risk of intrauterine vertical transmission of...
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Zahra Heydarifard Jila Yavarian Somayeh Shatizadeh Malekshahi Sevrin Zadheidar Talat Mokhtari-Azad Nazanin Zahra Shafiei-Jandaghi Source Type: research

Astaxanthin protective barrier and its ability to improve the health in patients with COVID-19
Iran J Microbiol. 2021 Aug;13(4):434-441. doi: 10.18502/ijm.v13i4.6965.ABSTRACTInflammation acts like a double-edged sword and can be harmful if not appropriately controlled. COVID-19 is created through a novel species of coronavirus SARS-CoV-2 (2019-nCoV). Elevated levels of inflammatory factors such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), etc. lead to Acute Respiratory Distress Syndrome (ARDS) and severe complications of infection in the lungs of coronavirus-infected patients. Astaxanthin is a natural and potent carotenoid with powerful antioxidant activity as well as an anti-inflammatory agen...
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Ali-Reza Ahmadi Roya Ayazi-Nasrabadi Source Type: research

Evaluation of < em > in vitro < /em > activity of ceftaroline on methicillin resistant < em > Staphylococcus aureus < /em > blood isolates from Iran
CONCLUSION: While resistance to CPT was not detected we found increased CPT MICs in 7.69% of MRSA isolates. Reduced susceptibility to CPT in the absence of mecA mutations is indicative of contribution of secondary chromosomal mutations in resistance development.PMID:34557271 | PMC:PMC8421581 | DOI:10.18502/ijm.v13i4.6967 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Negin Abdizadeh Mehri Haeili Hossein Samadi Kafil Amin Ahmadi Mohammad Mehdi Feizabadi Source Type: research

Genotypic and phenotypic characterization of < em > Streptococcus mutans < /em > strains isolated from patients with dental caries
This study evaluated the genotypic and phenotypic diversity of 209 S. mutans strains isolated from 336 patients with dental caries and compared with the universal reference strain, UA159.MATERIALS AND METHODS: Selective cultivation on mitis-salivaries-bacitracin agar and species-specific polymerase chain reaction (PCR) was carried out to isolate and identify the 209 S. mutans isolates from 336 patients with dental caries. Arbitrarily primed polymerase chain reaction (AP-PCR), PCR amplification of specific gene, acid production and biofilm formation capacity were performed to evaluate the genotypic and phenotypic variation....
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Mohammad Shahadat Hossain Sadab Alam Yead Morshed Nibir Tahrima Arman Tusty Sayyeed Mahmud Bulbul Mirajul Islam Mohammad Shahnoor Hossain Source Type: research

Biofilm formation and molecular analysis of intercellular adhesion gene cluster < em > (icaABCD) < /em > among < em > Staphylococcus aureus < /em > strains isolated from children with adenoiditis
CONCLUSION: Our findings indicated that icaABCD operon are associated with biofilm formation in S. aureus isolates, however the absence of these genes may not necessarily exclude this property.PMID:34557273 | PMC:PMC8421587 | DOI:10.18502/ijm.v13i4.6969 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Rasoul Ghaioumy Fatemehalsadat Tabatabaeifar Karamat Mozafarinia Aliasghar Arabi Mianroodi Elham Isaei Jos é Rubén Morones-Ramírez Setareh Agha Kuchak Afshari Davood Kalantar-Neyestanaki Source Type: research

Use of a new multiplex quantitative polymerase chain reaction based assay for simultaneous detection of < em > Neisseria meningitidis, Escherichia coli K < sub > 1 < /sub > < /em > , < em > Streptococcus agalactiae < /em > , and < em > Streptococcus pneumoniae < /em >
CONCLUSION: The remarkable benefit of this method is associated with the speed (up to 3 hours) at which the procedure could be completed. It is also worth noting that this method can reduce the personnel unintentional errors which may occur in the laboratory. On the other hand, as this method simultaneously identifies four common factors that cause bacterial meningitis, it could be used as an auxiliary method diagnostic technique in laboratories particularly in cases of emergency medicine.PMID:34557274 | PMC:PMC8421586 | DOI:10.18502/ijm.v13i4.6970 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Nastaran Hemmati Farhad Nikkhahi Amir Javadi Sahar Eskandarion Seyed Mahmoud Amin Marashi Source Type: research

High prevalence of multidrug-resistant non-fermentative Gram-negative bacilli harboring < em > bla < /em > < sub > IMP-1 < /sub > and < em > bla < /em > < sub > VIM-1 < /sub > metallo-beta-lactamase genes in Birjand, south-east Iran
Iran J Microbiol. 2021 Aug;13(4):470-479. doi: 10.18502/ijm.v13i4.6971.ABSTRACTBACKGROUND AND OBJECTIVES: Non-fermentative Gram-negative Bacilli (NFGNB) is known as a major cause of healthcare-associated infections with high levels of antibiotic resistance. The aim of this study was to investigate the antibiotic resistance profiles and molecular characteristics of metallo-beta-lactamase (MBL)-producing NFGNB.MATERIALS AND METHODS: In this cross-sectional study, the antibiotic resistance profile of 122 clinical NFGNB isolates was determined by the Kirby-Bauer disk diffusion and microdilution broth methods. Bacterial isolate...
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Mohammad Hasan Namaei Masoud Yousefi Parvin Askari Babak Roshanravan Ali Hashemi Yasaman Rezaei Source Type: research

Phylogenetic and molecular analysis based on genes 16S-rRNA, OMPA and POMP to identify < em > Chlamydia abortus < /em > infection occurrence at the milk samples of goats and sheep in west Azerbaijan of Iran
CONCLUSION: Phylogenetic analysis based on the gene of helicase showed that most of the isolates shared similarity> 99.97%.PMID:34557276 | PMC:PMC8421589 | DOI:10.18502/ijm.v13i4.6972 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Fariba Taheri Abdulghaffar Ownagh Karim Mardani Source Type: research

Role of biofilms in the survival of < em > Legionella pneumophila < /em > to sodium chloride treatment
CONCLUSION: Results from this study demonstrate that the sodium chloride disinfection strategy was effective on Legionella pneumophila planktonic cells but not on biofilms, which demonstrate the role of biofilms in the persistence and recolonization of L. pneumophila in water distribution systems.PMID:34557277 | PMC:PMC8421579 | DOI:10.18502/ijm.v13i4.6973 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Abdelwahid Assaidi Mostafa Ellouali Hassan Latrache Hafida Zahir El Mostafa Mliji Source Type: research

Mediastinal lymphadenopathy and prognosis of COVID-19 disease
This study aimed to investigate the mediastinal lymphadenopathy and the disease progression in COVID-19 patients.MATERIALS AND METHODS: In this case-control study, 195 COVID-19 patients were divided into two groups, with the mediastinal lymphadenopathy and without it. In these groups, demographic characteristics, underlying diseases, laboratory results, and outcomes were compared.RESULTS: The median age in the LAP group was higher than the opposite group (62 vs. 58.5; p= 0.037). SpO2 (85% vs. 90%; P
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Sanaz Pilechian Ali Pirsalehi Abolfazl Arabkoohi Source Type: research

First seroepidemiological investigation of human enterovirus 71 in Iran
This study, the first of this kind in Iran, aimed to find neutralizing antibodies against EV-A71 in serum of healthy individuals in different age groups based on neutralization test (NT).MATERIALS AND METHODS: In this cross-sectional study, 547 serum samples were collected from healthy individuals who were referring for routine checkup tests (aged from under 6 months to over 31 years old) to Imam-Khomeini Hospital in Tehran during January-December 2015. Serum samples were examined by NT in cell culture to detect neutralizing antibodies against EV-A71. In the next step, some of the positive samples were subjected to complet...
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Mahsa Javadi Ahmad Nejati Maryam Yousefi Mahmood Mahmoodi Zabihollah Shoja Shohreh Shahmahmoodi Source Type: research

Molecular epidemiology and phylogenetic analysis of human T-lymphotropic virus type 1 in the < em > tax < /em > gene and it association with adult t-cell leukemia/lymphoma disorders
CONCLUSION: Through phylogenetic and phylodynamic analyses HTLV-1 strain in Tehran were characterized in Iran. The appearance of HTLV-1 in Iran was probably happened by the ancient Silk Road which linked China to Antioch.PMID:34557280 | PMC:PMC8421578 | DOI:10.18502/ijm.v13i4.6976 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Samira Pourrezaei Shahrzad Shadabi Maryam Gheidishahran Abbas Rahimiforoushani Masoume Akhbari Mahnaz Tavakoli Mahshid Safavi Mobina Madihi Mehdi Norouzi Source Type: research

The mycological and molecular study of < em > Pneumocystis jiroveci < /em > pneumonia among HIV and non-HIV immunocompromised patients hospitalized in pulmonary units in Guilan, Northern Iran
CONCLUSION: Since PJP often causes symptoms that are similar to other illnesses, such as the flu or tuberculosis, clinical and laboratory findings should be used simultaneously for making the final decision on drug administration.PMID:34557281 | PMC:PMC8421585 | DOI:10.18502/ijm.v13i4.6977 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Zahra Rafat Keyhan Ashrafi Seyed Jamal Hashemi Elahe Sasani Alireza Naserani Hasti Kamali Sarvestani Farshid Hashemi Source Type: research

< em > CSU52 < /em > , a novel regulator functions as a repressor of L-sorbose utilization in < em > Candida albicans < /em >
CONCLUSION: This finding completes the identification of regulators in SUR1 pathway. This result paves the way to study the underlying molecular mechanisms of SOU1 gene regulation that in-turn helps to understand stress induced aneuploidy.PMID:34557282 | PMC:PMC8421577 | DOI:10.18502/ijm.v13i4.6978 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Dileep Pullepu Wasim Uddin Aswathy Narayanan M Anaul Kabir Source Type: research

Antibacterial activity of endosymbiotic bacterial compound from < em > Pheretima < /em > sp. earthworms inhibit the growth of < em > Salmonella < /em > Typhi and < em > Staphylococcus aureus < /em > : < em > in vitro < /em > and < em > in silico < /em > approach
CONCLUSION: Ten active compounds of endosymbiont bacteria, Cyclo (phenylalanyl-prolyl) and sedanolide were potential candidates for antibacterial compounds based on the inhibition test of the agar diffusion method and the results of reverse docking and Way2Drugs PASS.PMID:34557283 | PMC:PMC8421580 | DOI:10.18502/ijm.v13i4.6981 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Dirayah Rauf Husain Riuh Wardhani Source Type: research

Evaluation of cold atmospheric-pressure plasma against burn wound infections and gene silencing
CONCLUSION: Cold plasma showed pathogen inhibitory properties of P. aeruginosa and virulence alkaline protease and wound healing properties in animal models, so this inexpensive and suitable method can be presented to the medical community to disinfect burn wounds and improve wound healing.PMID:34557284 | PMC:PMC8421582 | DOI:10.18502/ijm.v13i4.6982 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Ensieh Abbasi Jalil Fallah Mehrabadi Mohamadreza Nourani Yasaman Nazar Namini Siamak Mohammadi Davoud Esmaeili Asieh Abbasi Source Type: research

Crude sulfated polysaccharides extracted from marine cyanobacterium < em > Oscillatoria simplicissima < /em > with evaluation antioxidant and cytotoxic activities
CONCLUSION: Microalgal polysaccharides have great therapeutically potential in drug development used as antitumor and antioxidant agents in near future.PMID:34557285 | PMC:PMC8421576 | DOI:10.18502/ijm.v13i4.6983 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Reham G Elkomy Mona M Ismail Source Type: research

Molecular characterization of healthcare and community-associated methicillin-resistant < em > Staphylococcus aureus < /em > using phage open-reading frame typing
Iran J Microbiol. 2021 Aug;13(4):560-564. doi: 10.18502/ijm.v13i4.6985.ABSTRACTThe polymerase chain reaction-based open reading frame typing (POT) method is a simple and rapid method for the strain-level discrimination of methicillin-resistant Staphylococcus aureus (MRSA). We investigated the molecular characteristics of S. aureus strains by multilocus sequencing typing (MLST) and POT and the profiles of antibiotic resistance and virulence genes of MRSA isolates in a single center of Tokyo, Japan. Five types by MLST and 19 types by POT were detected in the 25 MRSA isolates. ST5 and a POT1 score of 93 were associated with h...
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Takaaki Konuma Shunsuke Takahashi Masato Suzuki Arinobu Tojo Source Type: research

SARS-CoV-2: an imperative maternal-fetal concern
Iran J Microbiol. 2021 Aug;13(4):427-433. doi: 10.18502/ijm.v13i4.6963.ABSTRACTSevere acute respiratory syndrome corona virus 2 (SARS-CoV-2) is a newly emerged virus which belongs to Coronaviridae family within the betacoronavirus genus. Previous reports demonstrated that other betacoronaviruses were responsible for adverse outcomes during pregnancy in human. Due to inadequate data, the consequences of a SARS-CoV-2 infection during pregnancy is still a public health concern in the second year of SARS-CoV-2 circulation in human population. Herein, we aimed to review the probable risk of intrauterine vertical transmission of...
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Zahra Heydarifard Jila Yavarian Somayeh Shatizadeh Malekshahi Sevrin Zadheidar Talat Mokhtari-Azad Nazanin Zahra Shafiei-Jandaghi Source Type: research

Astaxanthin protective barrier and its ability to improve the health in patients with COVID-19
Iran J Microbiol. 2021 Aug;13(4):434-441. doi: 10.18502/ijm.v13i4.6965.ABSTRACTInflammation acts like a double-edged sword and can be harmful if not appropriately controlled. COVID-19 is created through a novel species of coronavirus SARS-CoV-2 (2019-nCoV). Elevated levels of inflammatory factors such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), etc. lead to Acute Respiratory Distress Syndrome (ARDS) and severe complications of infection in the lungs of coronavirus-infected patients. Astaxanthin is a natural and potent carotenoid with powerful antioxidant activity as well as an anti-inflammatory agen...
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Ali-Reza Ahmadi Roya Ayazi-Nasrabadi Source Type: research

Evaluation of < em > in vitro < /em > activity of ceftaroline on methicillin resistant < em > Staphylococcus aureus < /em > blood isolates from Iran
CONCLUSION: While resistance to CPT was not detected we found increased CPT MICs in 7.69% of MRSA isolates. Reduced susceptibility to CPT in the absence of mecA mutations is indicative of contribution of secondary chromosomal mutations in resistance development.PMID:34557271 | PMC:PMC8421581 | DOI:10.18502/ijm.v13i4.6967 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Negin Abdizadeh Mehri Haeili Hossein Samadi Kafil Amin Ahmadi Mohammad Mehdi Feizabadi Source Type: research

Genotypic and phenotypic characterization of < em > Streptococcus mutans < /em > strains isolated from patients with dental caries
This study evaluated the genotypic and phenotypic diversity of 209 S. mutans strains isolated from 336 patients with dental caries and compared with the universal reference strain, UA159.MATERIALS AND METHODS: Selective cultivation on mitis-salivaries-bacitracin agar and species-specific polymerase chain reaction (PCR) was carried out to isolate and identify the 209 S. mutans isolates from 336 patients with dental caries. Arbitrarily primed polymerase chain reaction (AP-PCR), PCR amplification of specific gene, acid production and biofilm formation capacity were performed to evaluate the genotypic and phenotypic variation....
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Mohammad Shahadat Hossain Sadab Alam Yead Morshed Nibir Tahrima Arman Tusty Sayyeed Mahmud Bulbul Mirajul Islam Mohammad Shahnoor Hossain Source Type: research

Biofilm formation and molecular analysis of intercellular adhesion gene cluster < em > (icaABCD) < /em > among < em > Staphylococcus aureus < /em > strains isolated from children with adenoiditis
CONCLUSION: Our findings indicated that icaABCD operon are associated with biofilm formation in S. aureus isolates, however the absence of these genes may not necessarily exclude this property.PMID:34557273 | PMC:PMC8421587 | DOI:10.18502/ijm.v13i4.6969 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Rasoul Ghaioumy Fatemehalsadat Tabatabaeifar Karamat Mozafarinia Aliasghar Arabi Mianroodi Elham Isaei Jos é Rubén Morones-Ramírez Setareh Agha Kuchak Afshari Davood Kalantar-Neyestanaki Source Type: research

Use of a new multiplex quantitative polymerase chain reaction based assay for simultaneous detection of < em > Neisseria meningitidis, Escherichia coli K < sub > 1 < /sub > < /em > , < em > Streptococcus agalactiae < /em > , and < em > Streptococcus pneumoniae < /em >
CONCLUSION: The remarkable benefit of this method is associated with the speed (up to 3 hours) at which the procedure could be completed. It is also worth noting that this method can reduce the personnel unintentional errors which may occur in the laboratory. On the other hand, as this method simultaneously identifies four common factors that cause bacterial meningitis, it could be used as an auxiliary method diagnostic technique in laboratories particularly in cases of emergency medicine.PMID:34557274 | PMC:PMC8421586 | DOI:10.18502/ijm.v13i4.6970 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Nastaran Hemmati Farhad Nikkhahi Amir Javadi Sahar Eskandarion Seyed Mahmoud Amin Marashi Source Type: research

High prevalence of multidrug-resistant non-fermentative Gram-negative bacilli harboring < em > bla < /em > < sub > IMP-1 < /sub > and < em > bla < /em > < sub > VIM-1 < /sub > metallo-beta-lactamase genes in Birjand, south-east Iran
Iran J Microbiol. 2021 Aug;13(4):470-479. doi: 10.18502/ijm.v13i4.6971.ABSTRACTBACKGROUND AND OBJECTIVES: Non-fermentative Gram-negative Bacilli (NFGNB) is known as a major cause of healthcare-associated infections with high levels of antibiotic resistance. The aim of this study was to investigate the antibiotic resistance profiles and molecular characteristics of metallo-beta-lactamase (MBL)-producing NFGNB.MATERIALS AND METHODS: In this cross-sectional study, the antibiotic resistance profile of 122 clinical NFGNB isolates was determined by the Kirby-Bauer disk diffusion and microdilution broth methods. Bacterial isolate...
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Mohammad Hasan Namaei Masoud Yousefi Parvin Askari Babak Roshanravan Ali Hashemi Yasaman Rezaei Source Type: research

Phylogenetic and molecular analysis based on genes 16S-rRNA, OMPA and POMP to identify < em > Chlamydia abortus < /em > infection occurrence at the milk samples of goats and sheep in west Azerbaijan of Iran
CONCLUSION: Phylogenetic analysis based on the gene of helicase showed that most of the isolates shared similarity> 99.97%.PMID:34557276 | PMC:PMC8421589 | DOI:10.18502/ijm.v13i4.6972 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Fariba Taheri Abdulghaffar Ownagh Karim Mardani Source Type: research

Role of biofilms in the survival of < em > Legionella pneumophila < /em > to sodium chloride treatment
CONCLUSION: Results from this study demonstrate that the sodium chloride disinfection strategy was effective on Legionella pneumophila planktonic cells but not on biofilms, which demonstrate the role of biofilms in the persistence and recolonization of L. pneumophila in water distribution systems.PMID:34557277 | PMC:PMC8421579 | DOI:10.18502/ijm.v13i4.6973 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Abdelwahid Assaidi Mostafa Ellouali Hassan Latrache Hafida Zahir El Mostafa Mliji Source Type: research

Mediastinal lymphadenopathy and prognosis of COVID-19 disease
This study aimed to investigate the mediastinal lymphadenopathy and the disease progression in COVID-19 patients.MATERIALS AND METHODS: In this case-control study, 195 COVID-19 patients were divided into two groups, with the mediastinal lymphadenopathy and without it. In these groups, demographic characteristics, underlying diseases, laboratory results, and outcomes were compared.RESULTS: The median age in the LAP group was higher than the opposite group (62 vs. 58.5; p= 0.037). SpO2 (85% vs. 90%; P
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Sanaz Pilechian Ali Pirsalehi Abolfazl Arabkoohi Source Type: research

First seroepidemiological investigation of human enterovirus 71 in Iran
This study, the first of this kind in Iran, aimed to find neutralizing antibodies against EV-A71 in serum of healthy individuals in different age groups based on neutralization test (NT).MATERIALS AND METHODS: In this cross-sectional study, 547 serum samples were collected from healthy individuals who were referring for routine checkup tests (aged from under 6 months to over 31 years old) to Imam-Khomeini Hospital in Tehran during January-December 2015. Serum samples were examined by NT in cell culture to detect neutralizing antibodies against EV-A71. In the next step, some of the positive samples were subjected to complet...
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Mahsa Javadi Ahmad Nejati Maryam Yousefi Mahmood Mahmoodi Zabihollah Shoja Shohreh Shahmahmoodi Source Type: research

Molecular epidemiology and phylogenetic analysis of human T-lymphotropic virus type 1 in the < em > tax < /em > gene and it association with adult t-cell leukemia/lymphoma disorders
CONCLUSION: Through phylogenetic and phylodynamic analyses HTLV-1 strain in Tehran were characterized in Iran. The appearance of HTLV-1 in Iran was probably happened by the ancient Silk Road which linked China to Antioch.PMID:34557280 | PMC:PMC8421578 | DOI:10.18502/ijm.v13i4.6976 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Samira Pourrezaei Shahrzad Shadabi Maryam Gheidishahran Abbas Rahimiforoushani Masoume Akhbari Mahnaz Tavakoli Mahshid Safavi Mobina Madihi Mehdi Norouzi Source Type: research

The mycological and molecular study of < em > Pneumocystis jiroveci < /em > pneumonia among HIV and non-HIV immunocompromised patients hospitalized in pulmonary units in Guilan, Northern Iran
CONCLUSION: Since PJP often causes symptoms that are similar to other illnesses, such as the flu or tuberculosis, clinical and laboratory findings should be used simultaneously for making the final decision on drug administration.PMID:34557281 | PMC:PMC8421585 | DOI:10.18502/ijm.v13i4.6977 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Zahra Rafat Keyhan Ashrafi Seyed Jamal Hashemi Elahe Sasani Alireza Naserani Hasti Kamali Sarvestani Farshid Hashemi Source Type: research

< em > CSU52 < /em > , a novel regulator functions as a repressor of L-sorbose utilization in < em > Candida albicans < /em >
CONCLUSION: This finding completes the identification of regulators in SUR1 pathway. This result paves the way to study the underlying molecular mechanisms of SOU1 gene regulation that in-turn helps to understand stress induced aneuploidy.PMID:34557282 | PMC:PMC8421577 | DOI:10.18502/ijm.v13i4.6978 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 24, 2021 Category: Microbiology Authors: Dileep Pullepu Wasim Uddin Aswathy Narayanan M Anaul Kabir Source Type: research