Intracavernous Schwannoma Characterized With 18F-FDG, 68Ga-DOTATOC, and 18F-Choline PET
We report the case of a 75-year-old man with history of prostate cancer whose left intracavernous lesion was successfully characterized by 3 PETs performed successively with different tracers. This poorly characterized tumor was initially discovered on an MRI conducted to investigate an acute diplopia and slowly growing during follow-up. On 18F-FDG PET, the lesion showed no significant uptake, and no extracranial lesion was found nor did it have increased 68Ga-DOTATOC uptake. Finally, this tumor displayed a high 18F-choline uptake, and no extracranial lesion was revealed with this tracer. The diagnosis of schwannoma withou...
Source: Clinical Prostate Cancer - October 18, 2021 Category: Cancer & Oncology Authors: Julien Farce Isabelle Lecouillard B éatrice Carsin Nicol Maxime Bretonnier Antoine Girard Source Type: research

Intrameningioma metastasis: A case-based literature review
We report a case of a 66-year-old female, with known Small Cell Lung Cancer, who presented with left-sided hemiparesis. The Magnetic Resonance Imaging scan revealed a right frontal extra-axial mass. The patient underwent a craniotomy and a gross total removal of the tumor. Histological examination of the excised mass revealed metastatic adenocarcinoma deposits inside a meningioma: tumor-to-tumor metastasis. Reviewing the available literature, it has been hypothesized that the following factors play a role in the pathophysiology of this phenomenon: progesterone and estrogen receptors, cell-to-cell adhesion molecules, rich v...
Source: Clinical Prostate Cancer - October 17, 2021 Category: Cancer & Oncology Authors: Benjamin Konstantinos Papadakis Eleftherios Vorrias Konstantin Br äutigam Nikolaos Chochlidakis Anastasios Koutsopoulos Dimitrios Mavroudis Antonis Vakis Christos Tsitsipanis Source Type: research

LncRNA FGF14-AS2 represses growth of prostate carcinoma cells via modulating miR-96-5p/AJAP1 axis
CONCLUSION: lncRNA FGF14-AS2 was a downregulated lncRNA in prostate carcinoma and influenced cell proliferation and metastasis. The influence relied on modulating miR-96-5p and its target gene AJAP1.PMID:34655124 | DOI:10.1002/jcla.24012 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - October 16, 2021 Category: Cancer & Oncology Authors: Rubing Li Yingcong Chen Jingwei Wu Xiaobo Cui Sinian Zheng Huaqing Yan Yiming Wu Feng Wang Source Type: research

LncRNA FGF14-AS2 represses growth of prostate carcinoma cells via modulating miR-96-5p/AJAP1 axis
CONCLUSION: lncRNA FGF14-AS2 was a downregulated lncRNA in prostate carcinoma and influenced cell proliferation and metastasis. The influence relied on modulating miR-96-5p and its target gene AJAP1.PMID:34655124 | DOI:10.1002/jcla.24012 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - October 16, 2021 Category: Cancer & Oncology Authors: Rubing Li Yingcong Chen Jingwei Wu Xiaobo Cui Sinian Zheng Huaqing Yan Yiming Wu Feng Wang Source Type: research

Stereotactic body radiotherapy to lymph nodes in oligoprogressive castration-resistant prostate cancer patients: a post hoc analysis from two phase I clinical trials
In conclusion, the efficacy in terms of LC of SBRT/SRS in patients with nodal metastases from PC was confirmed. Moreover, this analysis suggests the efficacy in terms of PFS and NEST-FS also in the setting of oligoprogressive PC. In fact, about one-third of patients were free from progressive disease and two-third of subjects did not require hormonal therapy switch or discontinuation three years after treatment.PMID:34651242 | DOI:10.1007/s10585-021-10126-7 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - October 15, 2021 Category: Cancer & Oncology Authors: D Pezzulla G Macchia S Cilla M Buwenge M Ferro P Bonome C Romano A Zamagni V Valentini A G Morganti F Deodato Source Type: research

Incidental [18F]PSMA-1007 Appendiceal Uptake Mimicking Nodal Disease
Clin Nucl Med. 2021 Oct 12. doi: 10.1097/RLU.0000000000003920. Online ahead of print.ABSTRACTWhen interpreting an [18F]prostate specific membrane antigen (PSMA)-1007 PET/CT, it is important to understand the normal biodistribution of the tracer. A 73-year-old man with prostate cancer underwent [18F]PSMA-1007 PET/CT for biochemical recurrence. There was no abnormal uptake in the prostatectomy bed, but PSMA-avid pelvic nodal disease was found. Incidental intense focal uptake was also noted corresponding to the tip of the appendix, which was concluded to be physiological. This is an example of an uncommon site of physiologica...
Source: Clinical Prostate Cancer - October 15, 2021 Category: Cancer & Oncology Authors: Ayah Adel Nawwar Julie Searle Iain Douglas Lyburn Source Type: research

Excellent Response to Adapted Low-Dose 177Lu-PSMA-617 PSMA Therapy in Renal Compromise Patient
We report a case of a 74-year-old man with metastatic prostate cancer with comorbidities of diabetes mellitus, hypertension, and chronic kidney disease. In order to minimize radiation burden to kidneys, a lower dose of 4 GBq of 177Lu-PSMA-617 was prescribed instead of the usual 6 to 7 GBq. There was significant decrease in prostate-specific antigen levels and symptoms. Renal profile remained stable. This case highlights that compromised renal function is not a definite contraindication to radionuclide therapy, and doses can be modified based on risk versus benefits.PMID:34653057 | DOI:10.1097/RLU.0000000000003912 (Source: ...
Source: Clinical Prostate Cancer - October 15, 2021 Category: Cancer & Oncology Authors: Sharjeel Usmani Fareeda Al Kandari Ibrahim Alrekhais Shatha N Khalaf Najeeb Ahmed Source Type: research

Stereotactic body radiotherapy to lymph nodes in oligoprogressive castration-resistant prostate cancer patients: a post hoc analysis from two phase I clinical trials
In conclusion, the efficacy in terms of LC of SBRT/SRS in patients with nodal metastases from PC was confirmed. Moreover, this analysis suggests the efficacy in terms of PFS and NEST-FS also in the setting of oligoprogressive PC. In fact, about one-third of patients were free from progressive disease and two-third of subjects did not require hormonal therapy switch or discontinuation three years after treatment.PMID:34651242 | DOI:10.1007/s10585-021-10126-7 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - October 15, 2021 Category: Cancer & Oncology Authors: D Pezzulla G Macchia S Cilla M Buwenge M Ferro P Bonome C Romano A Zamagni V Valentini A G Morganti F Deodato Source Type: research

Incidental [18F]PSMA-1007 Appendiceal Uptake Mimicking Nodal Disease
Clin Nucl Med. 2021 Oct 12. doi: 10.1097/RLU.0000000000003920. Online ahead of print.ABSTRACTWhen interpreting an [18F]prostate specific membrane antigen (PSMA)-1007 PET/CT, it is important to understand the normal biodistribution of the tracer. A 73-year-old man with prostate cancer underwent [18F]PSMA-1007 PET/CT for biochemical recurrence. There was no abnormal uptake in the prostatectomy bed, but PSMA-avid pelvic nodal disease was found. Incidental intense focal uptake was also noted corresponding to the tip of the appendix, which was concluded to be physiological. This is an example of an uncommon site of physiologica...
Source: Clinical Prostate Cancer - October 15, 2021 Category: Cancer & Oncology Authors: Ayah Adel Nawwar Julie Searle Iain Douglas Lyburn Source Type: research

Excellent Response to Adapted Low-Dose 177Lu-PSMA-617 PSMA Therapy in Renal Compromise Patient
We report a case of a 74-year-old man with metastatic prostate cancer with comorbidities of diabetes mellitus, hypertension, and chronic kidney disease. In order to minimize radiation burden to kidneys, a lower dose of 4 GBq of 177Lu-PSMA-617 was prescribed instead of the usual 6 to 7 GBq. There was significant decrease in prostate-specific antigen levels and symptoms. Renal profile remained stable. This case highlights that compromised renal function is not a definite contraindication to radionuclide therapy, and doses can be modified based on risk versus benefits.PMID:34653057 | DOI:10.1097/RLU.0000000000003912 (Source: ...
Source: Clinical Prostate Cancer - October 15, 2021 Category: Cancer & Oncology Authors: Sharjeel Usmani Fareeda Al Kandari Ibrahim Alrekhais Shatha N Khalaf Najeeb Ahmed Source Type: research

Nomogram Incorporating Contrast-Enhanced Ultrasonography Predicting Time to the Development of Castration-Resistant Prostate Cancer
This study aimed to build and validate a nomogram incorporating the clinicopathologic characteristics and the parameters of contrast-enhanced ultrasonography (CEUS) to predict the time to CRPC after androgen deprivation therapy (ADT).METHODS: Patients with PCa were divided into the training (n = 183) and validation cohorts (n = 37) for nomogram construction and validation. The clinicopathologic characteristics and CEUS parameters were analyzed to determine the independent prognosis factors and serve as the basis of the nomogram to estimate the risk of 1-, 2-, and 3-year progress to CRPC.RESULTS: T stage, distant metastasis...
Source: Clinical Prostate Cancer - October 14, 2021 Category: Cancer & Oncology Authors: Yun-Xin Zhao Guang-Li Yao Jian Sun Xiao-Lian Wang Ying Wang Qiu-Qiong Cai Hui-Li Kang Li-Ping Gu Jia-Shun Yu Wen-Min Li Bei Zhang Jian Wang Jiang-Jun Mei Yi Jiang Source Type: research

Patterns of Prostate-Specific Antigen Testing and Prostate Biopsies During the COVID-19 Pandemic
CONCLUSION: The findings suggest that a substantial number of prostate screening opportunities and cancer diagnoses have been missed. Efforts are needed to bring such patients back for screening and diagnostic testing and to restore appropriate care for non-COVID-19-related medical conditions.PMID:34648367 | DOI:10.1200/CCI.21.00074 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - October 14, 2021 Category: Cancer & Oncology Authors: Harvey W Kaufman Zhen Chen Justin K Niles Jeff Radcliff Yuri Fesko Source Type: research

Nomogram Incorporating Contrast-Enhanced Ultrasonography Predicting Time to the Development of Castration-Resistant Prostate Cancer
This study aimed to build and validate a nomogram incorporating the clinicopathologic characteristics and the parameters of contrast-enhanced ultrasonography (CEUS) to predict the time to CRPC after androgen deprivation therapy (ADT).METHODS: Patients with PCa were divided into the training (n = 183) and validation cohorts (n = 37) for nomogram construction and validation. The clinicopathologic characteristics and CEUS parameters were analyzed to determine the independent prognosis factors and serve as the basis of the nomogram to estimate the risk of 1-, 2-, and 3-year progress to CRPC.RESULTS: T stage, distant metastasis...
Source: Clinical Prostate Cancer - October 14, 2021 Category: Cancer & Oncology Authors: Yun-Xin Zhao Guang-Li Yao Jian Sun Xiao-Lian Wang Ying Wang Qiu-Qiong Cai Hui-Li Kang Li-Ping Gu Jia-Shun Yu Wen-Min Li Bei Zhang Jian Wang Jiang-Jun Mei Yi Jiang Source Type: research

Management of Urological Malignancy in Heart and Lung Transplant Recipients: An Irish National Cohort Study
CONCLUSIONS: Urological malignancies are not common in heart and lung transplant recipients; however, standard management options can be safely used, including radical surgery. Prospective monitoring of these patients and potential considerations for screening should be maintained.PMID:34641776 | DOI:10.6002/ect.2021.0206 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - October 13, 2021 Category: Cancer & Oncology Authors: Robert A Keenan Usman Haroon Paul Ryan Bronagh Harrington Andrew Jones Mohammed Aboelmagd Stephen Connolly Kiaran J O'Mally David Galvin Nicholas Hegarty Source Type: research

Health and life insurance-related problems in very long-term cancer survivors in Germany: a population-based study
CONCLUSION: Most cancer survivors did not change their HI nor tried to buy LI after cancer diagnosis. Problems with changing statutory HI were generally resolved with additional contribution while the main problem encountered when buying LI was rejection of request.PMID:34642793 | DOI:10.1007/s00432-021-03825-x (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - October 13, 2021 Category: Cancer & Oncology Authors: Melissa S Y Thong Daniela Doege Linda Wei ßer Lena Koch-Gallenkamp Heike Bertram Andrea Eberle Bernd Holleczek Alice Nennecke Annika Waldmann Sylke Ruth Zeissig Ron Pritzkuleit Michael Schlander Hermann Brenner Volker Arndt Source Type: research

The TRIM proteins in cancer: from expression to emerging regulatory mechanisms
Clin Transl Oncol. 2021 Oct 13. doi: 10.1007/s12094-021-02715-5. Online ahead of print.ABSTRACTNew clinical evidence suggests that dysregulation of the ubiquitin-mediated destruction of tumor suppressors or oncogene products is probably engaged in the etiology of leukemia and carcinoma. The superfamily of tripartite motif (TRIM)-containing protein family is among the biggest recognized single protein RING finger E3 ubiquitin ligases that are considered vital carcinogenesis regulators, which is not shocking since TRIM proteins are engaged in various biological processes, including cell growth, development, and differentiati...
Source: Clinical Prostate Cancer - October 13, 2021 Category: Cancer & Oncology Authors: A Mohammadi M S Pour Abbasi S Khorrami S Khodamoradi Z Mohammadi Goldar F Ebrahimzadeh Source Type: research

How quality of life can help guide selection of androgen receptor inhibitors in nonmetastatic castration-resistant prostate cancer
Clin Adv Hematol Oncol. 2021 Oct;19(10):627-630.NO ABSTRACTPMID:34637427 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - October 12, 2021 Category: Cancer & Oncology Authors: Matthew R Smith Source Type: research

TAXOMET: A French Prospective Multicentric Randomized Phase II Study of Docetaxel Plus Metformin Versus Docetaxel Plus Placebo in Metastatic Castration-Resistant Prostate Cancer
CONCLUSION: MET addition failed to improve the standard DOCE regimen in mCRPC. Further research targeting tumor cell metabolism should be performed.PMID:34629300 | DOI:10.1016/j.clgc.2021.08.008 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - October 11, 2021 Category: Cancer & Oncology Authors: Marc Pujalte Martin Delphine Borchiellini Brice Thamphya Aline Guillot Jean-Baptiste Paoli Dominique Besson Werner Hilgers Frank Priou Claude El Kouri Benjamin Hoch Jean-Laurent Deville Renaud Schiappa Sandrine Cheli G érard Milano Jean-Fran çois Tanti Source Type: research

Presence of serum RalA and serum p53 autoantibodies in 1833 patients with various types of cancers
This study aimed to evaluate the relationship between s-RalA-Abs and s-p53-Abs in various types of cancer.METHODS: A total of 1833 cancer patients (esophageal cancer, 172; hepatocellular carcinoma, 91; lung cancer, 269; gastric cancer, 317; colon cancer, 262; breast cancer, 364; and prostate cancer, 358) and 73 healthy subjects were enrolled in the study. The levels of s-RalA-Abs and s-p53-Abs were analyzed using enzyme-linked immunosorbent assay, and the positivity rates and relations between the two autoantibodies were evaluated. The cutoff values for s-RalA abs and s-p53 abs were set as mean + 2 standard deviation and t...
Source: Clinical Prostate Cancer - October 11, 2021 Category: Cancer & Oncology Authors: Tatsuki Nanami Isamu Hoshino Fumiaki Shiratori Satoshi Yajima Yoko Oshima Takashi Suzuki Masaaki Ito Takaki Hiwasa Akiko Kuwajima Hideaki Shimada Source Type: research

TAXOMET: A French Prospective Multicentric Randomized Phase II Study of Docetaxel Plus Metformin Versus Docetaxel Plus Placebo in Metastatic Castration-Resistant Prostate Cancer
CONCLUSION: MET addition failed to improve the standard DOCE regimen in mCRPC. Further research targeting tumor cell metabolism should be performed.PMID:34629300 | DOI:10.1016/j.clgc.2021.08.008 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - October 11, 2021 Category: Cancer & Oncology Authors: Marc Pujalte Martin Delphine Borchiellini Brice Thamphya Aline Guillot Jean-Baptiste Paoli Dominique Besson Werner Hilgers Frank Priou Claude El Kouri Benjamin Hoch Jean-Laurent Deville Renaud Schiappa Sandrine Cheli G érard Milano Jean-Fran çois Tanti Source Type: research

Presence of serum RalA and serum p53 autoantibodies in 1833 patients with various types of cancers
This study aimed to evaluate the relationship between s-RalA-Abs and s-p53-Abs in various types of cancer.METHODS: A total of 1833 cancer patients (esophageal cancer, 172; hepatocellular carcinoma, 91; lung cancer, 269; gastric cancer, 317; colon cancer, 262; breast cancer, 364; and prostate cancer, 358) and 73 healthy subjects were enrolled in the study. The levels of s-RalA-Abs and s-p53-Abs were analyzed using enzyme-linked immunosorbent assay, and the positivity rates and relations between the two autoantibodies were evaluated. The cutoff values for s-RalA abs and s-p53 abs were set as mean + 2 standard deviation and t...
Source: Clinical Prostate Cancer - October 11, 2021 Category: Cancer & Oncology Authors: Tatsuki Nanami Isamu Hoshino Fumiaki Shiratori Satoshi Yajima Yoko Oshima Takashi Suzuki Masaaki Ito Takaki Hiwasa Akiko Kuwajima Hideaki Shimada Source Type: research

TAXOMET: A French Prospective Multicentric Randomized Phase II Study of Docetaxel Plus Metformin Versus Docetaxel Plus Placebo in Metastatic Castration-Resistant Prostate Cancer
CONCLUSION: MET addition failed to improve the standard DOCE regimen in mCRPC. Further research targeting tumor cell metabolism should be performed.PMID:34629300 | DOI:10.1016/j.clgc.2021.08.008 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - October 11, 2021 Category: Cancer & Oncology Authors: Marc Pujalte Martin Delphine Borchiellini Brice Thamphya Aline Guillot Jean-Baptiste Paoli Dominique Besson Werner Hilgers Frank Priou Claude El Kouri Benjamin Hoch Jean-Laurent Deville Renaud Schiappa Sandrine Cheli G érard Milano Jean-Fran çois Tanti Source Type: research

Presence of serum RalA and serum p53 autoantibodies in 1833 patients with various types of cancers
This study aimed to evaluate the relationship between s-RalA-Abs and s-p53-Abs in various types of cancer.METHODS: A total of 1833 cancer patients (esophageal cancer, 172; hepatocellular carcinoma, 91; lung cancer, 269; gastric cancer, 317; colon cancer, 262; breast cancer, 364; and prostate cancer, 358) and 73 healthy subjects were enrolled in the study. The levels of s-RalA-Abs and s-p53-Abs were analyzed using enzyme-linked immunosorbent assay, and the positivity rates and relations between the two autoantibodies were evaluated. The cutoff values for s-RalA abs and s-p53 abs were set as mean + 2 standard deviation and t...
Source: Clinical Prostate Cancer - October 11, 2021 Category: Cancer & Oncology Authors: Tatsuki Nanami Isamu Hoshino Fumiaki Shiratori Satoshi Yajima Yoko Oshima Takashi Suzuki Masaaki Ito Takaki Hiwasa Akiko Kuwajima Hideaki Shimada Source Type: research

Radical Cystectomy vs. Radiotherapy in Urothelial Bladder Cancer in Elderly and Very Elderly Patients
Clin Genitourin Cancer. 2021 Sep 1:S1558-7673(21)00160-9. doi: 10.1016/j.clgc.2021.08.003. Online ahead of print.ABSTRACTINTRODUCTION: Controversy regarding cancer-specific mortality (CSM) of elderly and very elderly patients with muscle-invasive, non-metastatic, urothelial carcinoma of the urinary bladder (UCUB) undergoing radical cystectomy (RC) vs radiotherapy (RT) still exists.MATERIALS AND METHODS: In the 2004-2016 Surveillance, Epidemiology and End Results (SEER) database, we identified 2663 UCUB patients aged 75-79 (1808 RC vs 855 RT) and 3569 UCUB patients aged 80-89 (1551 RC vs 2018 RT). After stratification for c...
Source: Clinical Prostate Cancer - October 8, 2021 Category: Cancer & Oncology Authors: Benedikt Horlemann Christoph W ürnschimmel Benedikt Hoeh Gabriele Sorce Francesco Chierigo Rocco Simone Flammia Zhe Tian Fred Saad Alberto Briganti Sharokh F Shariat Michele Galucci Felix K H Chun Markus Graefen Pierre I Karakiewicz Source Type: research

Algorithm for an automatic treatment planning system using a single-arc VMAT for prostate cancer
J Appl Clin Med Phys. 2021 Oct 8. doi: 10.1002/acm2.13442. Online ahead of print.ABSTRACTOptimization process in treatment planning for intensity-modulated radiation therapy varies with the treatment planner. Therefore, a large variation in the quality of dose distribution is usually observed. To reduce variation, an automatic optimizing toolkit was developed for the Monaco treatment planning system (Elekta AB, Stockholm, Sweden) for prostate cancer using volumetric-modulated arc therapy (VMAT). This toolkit was able to create plans automatically. However, most plans needed two arcs per treatment to ensure the dose coverag...
Source: Clinical Prostate Cancer - October 8, 2021 Category: Cancer & Oncology Authors: Takumi Kodama Shigehiro Kudo Shogo Hatanaka Masatsugu Hariu Munefumi Shimbo Takeo Takahashi Source Type: research

Deep learning-based classification and structure name standardization for organ at risk and target delineations in prostate cancer radiotherapy
J Appl Clin Med Phys. 2021 Oct 8. doi: 10.1002/acm2.13446. Online ahead of print.ABSTRACTRadiotherapy (RT) datasets can suffer from variations in annotation of organ at risk (OAR) and target structures. Annotation standards exist, but their description for prostate targets is limited. This restricts the use of such data for supervised machine learning purposes as it requires properly annotated data. The aim of this work was to develop a modality independent deep learning (DL) model for automatic classification and annotation of prostate RT DICOM structures. Delineated prostate organs at risk (OAR), support- and target stru...
Source: Clinical Prostate Cancer - October 8, 2021 Category: Cancer & Oncology Authors: Christian Jamtheim Gustafsson Michael Lempart Johan Sw ärd Emilia Persson Tufve Nyholm Camilla Thellenberg Karlsson Jonas Scherman Source Type: research

Radical Cystectomy vs. Radiotherapy in Urothelial Bladder Cancer in Elderly and Very Elderly Patients
Clin Genitourin Cancer. 2021 Sep 1:S1558-7673(21)00160-9. doi: 10.1016/j.clgc.2021.08.003. Online ahead of print.ABSTRACTINTRODUCTION: Controversy regarding cancer-specific mortality (CSM) of elderly and very elderly patients with muscle-invasive, non-metastatic, urothelial carcinoma of the urinary bladder (UCUB) undergoing radical cystectomy (RC) vs radiotherapy (RT) still exists.MATERIALS AND METHODS: In the 2004-2016 Surveillance, Epidemiology and End Results (SEER) database, we identified 2663 UCUB patients aged 75-79 (1808 RC vs 855 RT) and 3569 UCUB patients aged 80-89 (1551 RC vs 2018 RT). After stratification for c...
Source: Clinical Prostate Cancer - October 8, 2021 Category: Cancer & Oncology Authors: Benedikt Horlemann Christoph W ürnschimmel Benedikt Hoeh Gabriele Sorce Francesco Chierigo Rocco Simone Flammia Zhe Tian Fred Saad Alberto Briganti Sharokh F Shariat Michele Galucci Felix K H Chun Markus Graefen Pierre I Karakiewicz Source Type: research

Algorithm for an automatic treatment planning system using a single-arc VMAT for prostate cancer
J Appl Clin Med Phys. 2021 Oct 8. doi: 10.1002/acm2.13442. Online ahead of print.ABSTRACTOptimization process in treatment planning for intensity-modulated radiation therapy varies with the treatment planner. Therefore, a large variation in the quality of dose distribution is usually observed. To reduce variation, an automatic optimizing toolkit was developed for the Monaco treatment planning system (Elekta AB, Stockholm, Sweden) for prostate cancer using volumetric-modulated arc therapy (VMAT). This toolkit was able to create plans automatically. However, most plans needed two arcs per treatment to ensure the dose coverag...
Source: Clinical Prostate Cancer - October 8, 2021 Category: Cancer & Oncology Authors: Takumi Kodama Shigehiro Kudo Shogo Hatanaka Masatsugu Hariu Munefumi Shimbo Takeo Takahashi Source Type: research

Deep learning-based classification and structure name standardization for organ at risk and target delineations in prostate cancer radiotherapy
J Appl Clin Med Phys. 2021 Oct 8. doi: 10.1002/acm2.13446. Online ahead of print.ABSTRACTRadiotherapy (RT) datasets can suffer from variations in annotation of organ at risk (OAR) and target structures. Annotation standards exist, but their description for prostate targets is limited. This restricts the use of such data for supervised machine learning purposes as it requires properly annotated data. The aim of this work was to develop a modality independent deep learning (DL) model for automatic classification and annotation of prostate RT DICOM structures. Delineated prostate organs at risk (OAR), support- and target stru...
Source: Clinical Prostate Cancer - October 8, 2021 Category: Cancer & Oncology Authors: Christian Jamtheim Gustafsson Michael Lempart Johan Sw ärd Emilia Persson Tufve Nyholm Camilla Thellenberg Karlsson Jonas Scherman Source Type: research

Radical Cystectomy vs. Radiotherapy in Urothelial Bladder Cancer in Elderly and Very Elderly Patients
Clin Genitourin Cancer. 2021 Sep 1:S1558-7673(21)00160-9. doi: 10.1016/j.clgc.2021.08.003. Online ahead of print.ABSTRACTINTRODUCTION: Controversy regarding cancer-specific mortality (CSM) of elderly and very elderly patients with muscle-invasive, non-metastatic, urothelial carcinoma of the urinary bladder (UCUB) undergoing radical cystectomy (RC) vs radiotherapy (RT) still exists.MATERIALS AND METHODS: In the 2004-2016 Surveillance, Epidemiology and End Results (SEER) database, we identified 2663 UCUB patients aged 75-79 (1808 RC vs 855 RT) and 3569 UCUB patients aged 80-89 (1551 RC vs 2018 RT). After stratification for c...
Source: Clinical Prostate Cancer - October 8, 2021 Category: Cancer & Oncology Authors: Benedikt Horlemann Christoph W ürnschimmel Benedikt Hoeh Gabriele Sorce Francesco Chierigo Rocco Simone Flammia Zhe Tian Fred Saad Alberto Briganti Sharokh F Shariat Michele Galucci Felix K H Chun Markus Graefen Pierre I Karakiewicz Source Type: research

Algorithm for an automatic treatment planning system using a single-arc VMAT for prostate cancer
J Appl Clin Med Phys. 2021 Oct 8. doi: 10.1002/acm2.13442. Online ahead of print.ABSTRACTOptimization process in treatment planning for intensity-modulated radiation therapy varies with the treatment planner. Therefore, a large variation in the quality of dose distribution is usually observed. To reduce variation, an automatic optimizing toolkit was developed for the Monaco treatment planning system (Elekta AB, Stockholm, Sweden) for prostate cancer using volumetric-modulated arc therapy (VMAT). This toolkit was able to create plans automatically. However, most plans needed two arcs per treatment to ensure the dose coverag...
Source: Clinical Prostate Cancer - October 8, 2021 Category: Cancer & Oncology Authors: Takumi Kodama Shigehiro Kudo Shogo Hatanaka Masatsugu Hariu Munefumi Shimbo Takeo Takahashi Source Type: research

Deep learning-based classification and structure name standardization for organ at risk and target delineations in prostate cancer radiotherapy
J Appl Clin Med Phys. 2021 Oct 8. doi: 10.1002/acm2.13446. Online ahead of print.ABSTRACTRadiotherapy (RT) datasets can suffer from variations in annotation of organ at risk (OAR) and target structures. Annotation standards exist, but their description for prostate targets is limited. This restricts the use of such data for supervised machine learning purposes as it requires properly annotated data. The aim of this work was to develop a modality independent deep learning (DL) model for automatic classification and annotation of prostate RT DICOM structures. Delineated prostate organs at risk (OAR), support- and target stru...
Source: Clinical Prostate Cancer - October 8, 2021 Category: Cancer & Oncology Authors: Christian Jamtheim Gustafsson Michael Lempart Johan Sw ärd Emilia Persson Tufve Nyholm Camilla Thellenberg Karlsson Jonas Scherman Source Type: research

Circulating phosphorus level and risk of prostate cancer: a Mendelian randomization study
CONCLUSIONS: Our study suggested a potential causal relationship between circulating phosphorus and risk of prostate cancer. Further studies are warranted to elucidate the underlying mechanism of phosphorus in the development of prostate cancer.PMID:34617559 | DOI:10.1093/ajcn/nqab342 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - October 7, 2021 Category: Cancer & Oncology Authors: Linshuoshuo Lv Ding Ye Jie Chen Yu Qian Alan Nuo Fu Jie Song Hong Yang Bin Liu Xiaohui Sun Lingbin Du Yingying Mao Source Type: research

Stereotactic Body Radiotherapy for Prostate Cancer: Where, When, and Who? A Bibliometric Analysis
Am J Clin Oncol. 2021 Oct 6. doi: 10.1097/COC.0000000000000869. Online ahead of print.ABSTRACTOBJECTIVES: To provide an overview of the achievements and future research with stereotactic body radiotherapy (SBRT) in prostate cancer.METHODS: SBRT publications for prostate cancer were retrieved from the Web of Science and Dimension database. Bibliometric analyses were performed using VOSviewer and Prism graph. Analysis of variance test was used to compare the publication, citation, and the mean citation between specialty journals. Network maps were produced to identify authors' and countries' collaboration clusters.RESULTS: B...
Source: Clinical Prostate Cancer - October 7, 2021 Category: Cancer & Oncology Authors: Gustavo A Viani Andre G Gouveia Alexandre A Jacinto Fabio Y Moraes Source Type: research

Inhibitory effect of polyphenols (phenolic acids, lignans, and stilbenes) on cancer by regulating signal transduction pathways: a review
Clin Transl Oncol. 2021 Oct 5. doi: 10.1007/s12094-021-02709-3. Online ahead of print.ABSTRACTNatural products, especially polyphenols (phenolic acids, lignans, and stilbenes) are suggested to be more potent anticancer drugs because of their no or less adverse effects, excess availability, high accuracy, and secure mode of action. In the present review, potential anticancer mechanisms of action of some polyphenols including phenolic acids, lignans, and stilbenes are discussed based on clinical, epidemiological, in vivo, and in vitro studies. The emerging evidence revealed that phenolic acids, lignans, and stilbenes induced...
Source: Clinical Prostate Cancer - October 5, 2021 Category: Cancer & Oncology Authors: A Hazafa M O Iqbal U Javaid M B K Tareen D Amna A Ramzan S Piracha M Naeem Source Type: research

Possibility of paclitaxel to induce the stemness-related characteristics of prostate cancer cells
CONCLUSIONS: The results of the current study indicate that paclitaxel exposure may increase the stem cell-like properties of PC-3 prostate cancer cells.PMID:34610216 | DOI:10.17219/acem/140590 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - October 5, 2021 Category: Cancer & Oncology Authors: Fadime Mutlu I çduygu Hale Samli Asuman Özgöz Buse Vatansever Kuyas Hekimler Ozt ürk Egemen Akg ün Source Type: research

Inhibitory effect of polyphenols (phenolic acids, lignans, and stilbenes) on cancer by regulating signal transduction pathways: a review
Clin Transl Oncol. 2021 Oct 5. doi: 10.1007/s12094-021-02709-3. Online ahead of print.ABSTRACTNatural products, especially polyphenols (phenolic acids, lignans, and stilbenes) are suggested to be more potent anticancer drugs because of their no or less adverse effects, excess availability, high accuracy, and secure mode of action. In the present review, potential anticancer mechanisms of action of some polyphenols including phenolic acids, lignans, and stilbenes are discussed based on clinical, epidemiological, in vivo, and in vitro studies. The emerging evidence revealed that phenolic acids, lignans, and stilbenes induced...
Source: Clinical Prostate Cancer - October 5, 2021 Category: Cancer & Oncology Authors: A Hazafa M O Iqbal U Javaid M B K Tareen D Amna A Ramzan S Piracha M Naeem Source Type: research

Possibility of paclitaxel to induce the stemness-related characteristics of prostate cancer cells
CONCLUSIONS: The results of the current study indicate that paclitaxel exposure may increase the stem cell-like properties of PC-3 prostate cancer cells.PMID:34610216 | DOI:10.17219/acem/140590 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - October 5, 2021 Category: Cancer & Oncology Authors: Fadime Mutlu I çduygu Hale Samli Asuman Özgöz Buse Vatansever Kuyas Hekimler Ozt ürk Egemen Akg ün Source Type: research

Inhibitory effect of polyphenols (phenolic acids, lignans, and stilbenes) on cancer by regulating signal transduction pathways: a review
Clin Transl Oncol. 2021 Oct 5. doi: 10.1007/s12094-021-02709-3. Online ahead of print.ABSTRACTNatural products, especially polyphenols (phenolic acids, lignans, and stilbenes) are suggested to be more potent anticancer drugs because of their no or less adverse effects, excess availability, high accuracy, and secure mode of action. In the present review, potential anticancer mechanisms of action of some polyphenols including phenolic acids, lignans, and stilbenes are discussed based on clinical, epidemiological, in vivo, and in vitro studies. The emerging evidence revealed that phenolic acids, lignans, and stilbenes induced...
Source: Clinical Prostate Cancer - October 5, 2021 Category: Cancer & Oncology Authors: A Hazafa M O Iqbal U Javaid M B K Tareen D Amna A Ramzan S Piracha M Naeem Source Type: research

Possibility of paclitaxel to induce the stemness-related characteristics of prostate cancer cells
CONCLUSIONS: The results of the current study indicate that paclitaxel exposure may increase the stem cell-like properties of PC-3 prostate cancer cells.PMID:34610216 | DOI:10.17219/acem/140590 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - October 5, 2021 Category: Cancer & Oncology Authors: Fadime Mutlu I çduygu Hale Samli Asuman Özgöz Buse Vatansever Kuyas Hekimler Ozt ürk Egemen Akg ün Source Type: research

Oncosexology: Sexual Issues in the Male Cancer Survivor
Urol Clin North Am. 2021 Nov;48(4):591-602. doi: 10.1016/j.ucl.2021.07.001. Epub 2021 Aug 21.ABSTRACTOncosexology is a multidisciplinary field composed of physicians, nurses, psychologists, and other health care professionals focusing on sexual issues in patients with cancer. Although any cancer diagnosis or treatment can be associated with sexual dysfunction, pelvic malignancies (such as prostate, bladder, or colorectal cancer) have the highest rates of sexual dysfunction in men. This includes erectile dysfunction, testosterone deficiency, ejaculatory dysfunction, orgasmic dysfunction, sexual incontinence, and penile shor...
Source: Clinical Prostate Cancer - October 4, 2021 Category: Cancer & Oncology Authors: Carolyn A Salter John P Mulhall Source Type: research

Assessing concordance between patient-reported and investigator-reported CTCAE after proton beam therapy for prostate cancer
CONCLUSIONS: Our study shows a low agreement between IR-CTCAE and PRO-CTCAE in the setting of proton therapy for prostate cancer. Compared to patient-reported outcomes, physicians underestimated the frequency and severity of urinary symptoms and diarrhea at the end of treatment. Continued use of PROs should be strongly encouraged.PMID:34604551 | PMC:PMC8463742 | DOI:10.1016/j.ctro.2021.09.003 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - October 4, 2021 Category: Cancer & Oncology Authors: Roman O Kowalchuk David Hillman Thomas B Daniels Carlos E Vargas Jean-Claude M Rwigema William W Wong Bradley J Stish Amylou C Dueck Richard Choo Source Type: research

Bladder filling volume variation between the first and second day of planning computed tomography for prostate cancer radiation therapy and correlation with renal function
CONCLUSION: Patients with a higher eGFR show greater variation in bladder filling volume, and caution should be exercised when applying RT in these patients.PMID:34605179 | DOI:10.1111/ajco.13603 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - October 4, 2021 Category: Cancer & Oncology Authors: Naoya Ishibashi Toshiya Maebayashi Masakuni Sakaguchi Takuya Aizawa Masahiro Okada Source Type: research

Prostate cancer nomenclature at diagnosis can affect treatment decisions
CA Cancer J Clin. 2021 Oct 4. doi: 10.3322/caac.21700. Online ahead of print.NO ABSTRACTPMID:34606088 | DOI:10.3322/caac.21700 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - October 4, 2021 Category: Cancer & Oncology Authors: Mike Fillon Source Type: research

Distinguishing Meningioma From Metastasis of Prostate Cancer on 68Ga-PSMA PET/CT
We present a case of a metastatic prostate adenocarcinoma with PSMA-avid lesion in the right frontal lobe on 68Ga-PSMA PET/CT. Later, MRI confirmed the brain lesion as meningioma.PMID:34606488 | DOI:10.1097/RLU.0000000000003629 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - October 4, 2021 Category: Cancer & Oncology Authors: Nuh Filizoglu Kevser Oksuzoglu Salih Ozguven Source Type: research

Oncosexology: Sexual Issues in the Male Cancer Survivor
Urol Clin North Am. 2021 Nov;48(4):591-602. doi: 10.1016/j.ucl.2021.07.001. Epub 2021 Aug 21.ABSTRACTOncosexology is a multidisciplinary field composed of physicians, nurses, psychologists, and other health care professionals focusing on sexual issues in patients with cancer. Although any cancer diagnosis or treatment can be associated with sexual dysfunction, pelvic malignancies (such as prostate, bladder, or colorectal cancer) have the highest rates of sexual dysfunction in men. This includes erectile dysfunction, testosterone deficiency, ejaculatory dysfunction, orgasmic dysfunction, sexual incontinence, and penile shor...
Source: Clinical Prostate Cancer - October 4, 2021 Category: Cancer & Oncology Authors: Carolyn A Salter John P Mulhall Source Type: research

Assessing concordance between patient-reported and investigator-reported CTCAE after proton beam therapy for prostate cancer
CONCLUSIONS: Our study shows a low agreement between IR-CTCAE and PRO-CTCAE in the setting of proton therapy for prostate cancer. Compared to patient-reported outcomes, physicians underestimated the frequency and severity of urinary symptoms and diarrhea at the end of treatment. Continued use of PROs should be strongly encouraged.PMID:34604551 | PMC:PMC8463742 | DOI:10.1016/j.ctro.2021.09.003 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - October 4, 2021 Category: Cancer & Oncology Authors: Roman O Kowalchuk David Hillman Thomas B Daniels Carlos E Vargas Jean-Claude M Rwigema William W Wong Bradley J Stish Amylou C Dueck Richard Choo Source Type: research

Bladder filling volume variation between the first and second day of planning computed tomography for prostate cancer radiation therapy and correlation with renal function
CONCLUSION: Patients with a higher eGFR show greater variation in bladder filling volume, and caution should be exercised when applying RT in these patients.PMID:34605179 | DOI:10.1111/ajco.13603 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - October 4, 2021 Category: Cancer & Oncology Authors: Naoya Ishibashi Toshiya Maebayashi Masakuni Sakaguchi Takuya Aizawa Masahiro Okada Source Type: research

Imaging features of the evolving patterns of metastatic prostate cancer
Clin Radiol. 2021 Sep 28:S0009-9260(21)00430-X. doi: 10.1016/j.crad.2021.09.005. Online ahead of print.ABSTRACTThe pattern of metastases in prostate cancer (PC) is evolving. Increased use of imaging, newer imaging techniques with higher sensitivity for disease detection and patients receiving multiple lines of novel therapies with increased life expectancy are likely to be contributory. Awareness of metastatic disease patterns improves early diagnosis, accurate staging, and initiation of appropriate therapy, and can inform prognostic information and anticipate potential disease complications. The aim of this review is to d...
Source: Clinical Prostate Cancer - October 2, 2021 Category: Cancer & Oncology Authors: A Curcean S Curcean P Rescigno D Ap Dafydd A Tree A Reid D-M Koh A Sohaib N Tunariu J Shur Source Type: research

Pattern of Recurrence After Stereotactic Radiotherapy in Prostate Cancer Patients With Nodal Pelvic Relapse. A Multi-Institutional Retrospective Analysis
Clin Oncol (R Coll Radiol). 2021 Sep 28:S0936-6555(21)00349-6. doi: 10.1016/j.clon.2021.09.014. Online ahead of print.ABSTRACTAIMS: Currently, when nodal pelvic oligorecurrent disease is detected, no standard treatment option is recommended. One possible salvage option is nodal stereotactic body radiotherapy (SBRT). Here we analysed recurrence patterns after nodal SBRT in patients affected by pelvic oligometastatic relapse after radical prostatectomy, and androgen deprivation therapy (ADT)-free survival in this population.MATERIALS AND METHODS: Data on 93 patients consecutively treated in five different institutions for pe...
Source: Clinical Prostate Cancer - October 2, 2021 Category: Cancer & Oncology Authors: G Francolini C Bellini V Di Cataldo B Detti A Bruni G Alicino L Triggiani S La Mattina R M D'Angelillo C Demofonti R Mazzola F Cuccia F Alongi M Aquilano A G Allegra L P Ciccone L Burchini V Salvestrini I Morelli G Frosini I Desideri L Livi Source Type: research