Prognostic Risk Classification for Biochemical Relapse-Free Survival in Oligometastatic Recurrent Prostate Cancer Determined by Choline PET
CONCLUSION: Prognostic group classifications were confirmed: PSA
Source: Clinical Prostate Cancer - April 14, 2021 Category: Cancer & Oncology Authors: Gwenaelle Gravis Aur élie Autret Morgane Guibert-Broudic Thomas Duberg é Christophe Zemmour Patricia Carrier Naji Salem Delphine Badinand Lysian Cartier Emmanuel Gross Jochen Walz G éraldine Pignot Isabelle Brenot-Rossi Source Type: research

Salvage Radical Prostatectomy: Baseline Prostate Cancer Characteristics and Survival Across SEER Registries
CONCLUSION: SRP is rarely performed. In most SEER registries, SRP use is very occasional. More than 2 average annual SRPs were reported in only 5 of all registries. Nonetheless, across all registries, SRP patients showed marginal to moderate differences in PSA, cT stage, and age at diagnosis. However, at 10 years of follow-up, 1 of 5 SRP patients died of other causes and observed overall mortality was higher than expected (36%).PMID:33849813 | DOI:10.1016/j.clgc.2021.03.015 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 14, 2021 Category: Cancer & Oncology Authors: Mike Wenzel Christoph W ürnschimmel Luigi Nocera Claudia Coll à Ruvolo Zhe Tian Shahrokh F Shariat Fred Saad Alberto Briganti Markus Graefen Andreas Becker Luis A Kluth Philipp Mandel Felix K H Chun Pierre I Karakiewicz Source Type: research

Phase 2 multicenter study of enzalutamide in metastatic castration resistant prostate cancer to identify mechanisms driving resistance
CONCLUSIONS: Our results demonstrate that a large proportion of enzalutamide-treated patients have baseline and progression alterations in the AR pathway and tumor suppressor genes. We demonstrate an increased number of BRCA2 alterations post-enzalutamide highlighting importance of serial tumor sampling in CRPC.PMID:33849963 | DOI:10.1158/1078-0432.CCR-20-4616 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 14, 2021 Category: Cancer & Oncology Authors: Rana R McKay Lucia Kwak Jett Crowdis Jamie M Sperger Shuang G Zhao Wanling Xie Lillian Werner Rosina T Lis Zhenwei Zhang Xiao X Wei Joshua M Lang Eliezer M Van Allen Rupal S Bhatt Evan Y Yu Peter S Nelson Glenn J Bubley Bruce Montgomery Mary-Ellen Taplin Source Type: research

Prognostic Risk Classification for Biochemical Relapse-Free Survival in Oligometastatic Recurrent Prostate Cancer Determined by Choline PET
CONCLUSION: Prognostic group classifications were confirmed: PSA
Source: Clinical Prostate Cancer - April 14, 2021 Category: Cancer & Oncology Authors: Gwenaelle Gravis Aur élie Autret Morgane Guibert-Broudic Thomas Duberg é Christophe Zemmour Patricia Carrier Naji Salem Delphine Badinand Lysian Cartier Emmanuel Gross Jochen Walz G éraldine Pignot Isabelle Brenot-Rossi Source Type: research

Salvage Radical Prostatectomy: Baseline Prostate Cancer Characteristics and Survival Across SEER Registries
CONCLUSION: SRP is rarely performed. In most SEER registries, SRP use is very occasional. More than 2 average annual SRPs were reported in only 5 of all registries. Nonetheless, across all registries, SRP patients showed marginal to moderate differences in PSA, cT stage, and age at diagnosis. However, at 10 years of follow-up, 1 of 5 SRP patients died of other causes and observed overall mortality was higher than expected (36%).PMID:33849813 | DOI:10.1016/j.clgc.2021.03.015 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 14, 2021 Category: Cancer & Oncology Authors: Mike Wenzel Christoph W ürnschimmel Luigi Nocera Claudia Coll à Ruvolo Zhe Tian Shahrokh F Shariat Fred Saad Alberto Briganti Markus Graefen Andreas Becker Luis A Kluth Philipp Mandel Felix K H Chun Pierre I Karakiewicz Source Type: research

Phase 2 multicenter study of enzalutamide in metastatic castration resistant prostate cancer to identify mechanisms driving resistance
CONCLUSIONS: Our results demonstrate that a large proportion of enzalutamide-treated patients have baseline and progression alterations in the AR pathway and tumor suppressor genes. We demonstrate an increased number of BRCA2 alterations post-enzalutamide highlighting importance of serial tumor sampling in CRPC.PMID:33849963 | DOI:10.1158/1078-0432.CCR-20-4616 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 14, 2021 Category: Cancer & Oncology Authors: Rana R McKay Lucia Kwak Jett Crowdis Jamie M Sperger Shuang G Zhao Wanling Xie Lillian Werner Rosina T Lis Zhenwei Zhang Xiao X Wei Joshua M Lang Eliezer M Van Allen Rupal S Bhatt Evan Y Yu Peter S Nelson Glenn J Bubley Bruce Montgomery Mary-Ellen Taplin Source Type: research

Neuroendocrine cells of the prostate: Histology, biological functions, and molecular mechanisms
Precis Clin Med. 2021 Jan 28;4(1):25-34. doi: 10.1093/pcmedi/pbab003. eCollection 2021 Mar.ABSTRACTProstate cancer (PCa) is a common cause of cancer-related mortality in men worldwide. Although most men are diagnosed with low grade, indolent tumors that are potentially curable, a significant subset develops advanced disease where hormone therapy is required to target the androgen receptor (AR). Despite its initial effect, hormone therapy eventually fails and the tumor progresses to lethal stages even through continued inhibition of AR. This review article focuses on the role of PCa cellular heterogeneity in therapy resista...
Source: Clinical Prostate Cancer - April 12, 2021 Category: Cancer & Oncology Authors: William Butler Jiaoti Huang Source Type: research

Neuroendocrine cells of the prostate: Histology, biological functions, and molecular mechanisms
Precis Clin Med. 2021 Jan 28;4(1):25-34. doi: 10.1093/pcmedi/pbab003. eCollection 2021 Mar.ABSTRACTProstate cancer (PCa) is a common cause of cancer-related mortality in men worldwide. Although most men are diagnosed with low grade, indolent tumors that are potentially curable, a significant subset develops advanced disease where hormone therapy is required to target the androgen receptor (AR). Despite its initial effect, hormone therapy eventually fails and the tumor progresses to lethal stages even through continued inhibition of AR. This review article focuses on the role of PCa cellular heterogeneity in therapy resista...
Source: Clinical Prostate Cancer - April 12, 2021 Category: Cancer & Oncology Authors: William Butler Jiaoti Huang Source Type: research

Influence of repeated prostate-specific antigen screening on treatment pattern in a country with a limited social perception of prostate cancer: Korean national wide observational study
Investig Clin Urol. 2021 Mar 29. doi: 10.4111/icu.20200302. Online ahead of print.ABSTRACTPURPOSE: To investigate the real-world prevalence of repeated prostate-specific antigen (PSA) screening in Korea and its influence on the treatment pattern of the prostate cancer (PCa) over the last decade, during which PCa has become the 3rd most popular male cancer and PSA test has gained minimal social interest.MATERIALS AND METHODS: From Korean National Health Insurance Service data, men with newly diagnosed PCa from 2008 through 2016 were identified, then the treatment modalities between the repeated PSA screening (defined as at ...
Source: Clinical Prostate Cancer - April 9, 2021 Category: Cancer & Oncology Authors: Young Hwii Ko Sang Won Kim Source Type: research

Urinary microRNA-1913 to microRNA-3659 expression ratio as a non-invasive diagnostic biomarker for prostate cancer
CONCLUSIONS: The urinary miR-1913 to miR-3659 expression ratio was increased in PCa and may serve as a useful supplemental biomarker to PSA for the diagnosis of PCa, particularly in patients within the PSA gray zone.PMID:33834642 | DOI:10.4111/icu.20200488 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 9, 2021 Category: Cancer & Oncology Authors: Young Joon Byun Xuan Mei Piao Pildu Jeong Ho Won Kang Sung Phil Seo Sung Kwon Moon Jong Young Lee Yung Hyun Choi Hee Youn Lee Won Tae Kim Sang Cheol Lee Eun Jong Cha Seok Joong Yun Wun Jae Kim Source Type: research

A surgical Case of Synchronous Multiple Primary Lung Cancers with Small Cell Carcinoma and Squamous Cell Carcinoma
We report a rare case of synchronous multiple primary lung cancers, including small cell carcinoma.PMID:33835473 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 9, 2021 Category: Cancer & Oncology Authors: Hajime Watanabe Sakura Tomita Yoichiro Ikoma Mitsutomo Kohno Ryota Masuda Masayuki Iwazaki Source Type: research

Impact of a Genomic Test on Treatment Decision in a Predominantly African American Population With Favorable-Risk Prostate Cancer: A Randomized Trial
CONCLUSION: In contrast to other studies, the net effect of the GPS was to move patients away from AS, primarily among men with low health literacy. These findings have implications for our understanding of how prognostic molecular assays that generate probabilities of poor outcome can affect treatment decisions in diverse clinical populations.PMID:33835822 | DOI:10.1200/JCO.20.02997 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 9, 2021 Category: Cancer & Oncology Authors: Adam B Murphy Michael R Abern Li Liu Heidy Wang Courtney M P Hollowell Roohollah Sharifi Patricia Vidal Andre Kajdacsy-Balla Marin Sekosan Karen Ferrer Shoujin Wu Marlene Gallegos Patrice King-Lee Lisa K Sharp Carol E Ferrans Peter H Gann Source Type: research

Influence of repeated prostate-specific antigen screening on treatment pattern in a country with a limited social perception of prostate cancer: Korean national wide observational study
Investig Clin Urol. 2021 Mar 29. doi: 10.4111/icu.20200302. Online ahead of print.ABSTRACTPURPOSE: To investigate the real-world prevalence of repeated prostate-specific antigen (PSA) screening in Korea and its influence on the treatment pattern of the prostate cancer (PCa) over the last decade, during which PCa has become the 3rd most popular male cancer and PSA test has gained minimal social interest.MATERIALS AND METHODS: From Korean National Health Insurance Service data, men with newly diagnosed PCa from 2008 through 2016 were identified, then the treatment modalities between the repeated PSA screening (defined as at ...
Source: Clinical Prostate Cancer - April 9, 2021 Category: Cancer & Oncology Authors: Young Hwii Ko Sang Won Kim Source Type: research

Urinary microRNA-1913 to microRNA-3659 expression ratio as a non-invasive diagnostic biomarker for prostate cancer
CONCLUSIONS: The urinary miR-1913 to miR-3659 expression ratio was increased in PCa and may serve as a useful supplemental biomarker to PSA for the diagnosis of PCa, particularly in patients within the PSA gray zone.PMID:33834642 | DOI:10.4111/icu.20200488 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 9, 2021 Category: Cancer & Oncology Authors: Young Joon Byun Xuan Mei Piao Pildu Jeong Ho Won Kang Sung Phil Seo Sung Kwon Moon Jong Young Lee Yung Hyun Choi Hee Youn Lee Won Tae Kim Sang Cheol Lee Eun Jong Cha Seok Joong Yun Wun Jae Kim Source Type: research

A surgical Case of Synchronous Multiple Primary Lung Cancers with Small Cell Carcinoma and Squamous Cell Carcinoma
We report a rare case of synchronous multiple primary lung cancers, including small cell carcinoma.PMID:33835473 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 9, 2021 Category: Cancer & Oncology Authors: Hajime Watanabe Sakura Tomita Yoichiro Ikoma Mitsutomo Kohno Ryota Masuda Masayuki Iwazaki Source Type: research

Impact of a Genomic Test on Treatment Decision in a Predominantly African American Population With Favorable-Risk Prostate Cancer: A Randomized Trial
CONCLUSION: In contrast to other studies, the net effect of the GPS was to move patients away from AS, primarily among men with low health literacy. These findings have implications for our understanding of how prognostic molecular assays that generate probabilities of poor outcome can affect treatment decisions in diverse clinical populations.PMID:33835822 | DOI:10.1200/JCO.20.02997 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 9, 2021 Category: Cancer & Oncology Authors: Adam B Murphy Michael R Abern Li Liu Heidy Wang Courtney M P Hollowell Roohollah Sharifi Patricia Vidal Andre Kajdacsy-Balla Marin Sekosan Karen Ferrer Shoujin Wu Marlene Gallegos Patrice King-Lee Lisa K Sharp Carol E Ferrans Peter H Gann Source Type: research

Influence of repeated prostate-specific antigen screening on treatment pattern in a country with a limited social perception of prostate cancer: Korean national wide observational study
Investig Clin Urol. 2021 Mar 29. doi: 10.4111/icu.20200302. Online ahead of print.ABSTRACTPURPOSE: To investigate the real-world prevalence of repeated prostate-specific antigen (PSA) screening in Korea and its influence on the treatment pattern of the prostate cancer (PCa) over the last decade, during which PCa has become the 3rd most popular male cancer and PSA test has gained minimal social interest.MATERIALS AND METHODS: From Korean National Health Insurance Service data, men with newly diagnosed PCa from 2008 through 2016 were identified, then the treatment modalities between the repeated PSA screening (defined as at ...
Source: Clinical Prostate Cancer - April 9, 2021 Category: Cancer & Oncology Authors: Young Hwii Ko Sang Won Kim Source Type: research

Urinary microRNA-1913 to microRNA-3659 expression ratio as a non-invasive diagnostic biomarker for prostate cancer
CONCLUSIONS: The urinary miR-1913 to miR-3659 expression ratio was increased in PCa and may serve as a useful supplemental biomarker to PSA for the diagnosis of PCa, particularly in patients within the PSA gray zone.PMID:33834642 | DOI:10.4111/icu.20200488 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 9, 2021 Category: Cancer & Oncology Authors: Young Joon Byun Xuan Mei Piao Pildu Jeong Ho Won Kang Sung Phil Seo Sung Kwon Moon Jong Young Lee Yung Hyun Choi Hee Youn Lee Won Tae Kim Sang Cheol Lee Eun Jong Cha Seok Joong Yun Wun Jae Kim Source Type: research

A surgical Case of Synchronous Multiple Primary Lung Cancers with Small Cell Carcinoma and Squamous Cell Carcinoma
We report a rare case of synchronous multiple primary lung cancers, including small cell carcinoma.PMID:33835473 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 9, 2021 Category: Cancer & Oncology Authors: Hajime Watanabe Sakura Tomita Yoichiro Ikoma Mitsutomo Kohno Ryota Masuda Masayuki Iwazaki Source Type: research

Impact of a Genomic Test on Treatment Decision in a Predominantly African American Population With Favorable-Risk Prostate Cancer: A Randomized Trial
CONCLUSION: In contrast to other studies, the net effect of the GPS was to move patients away from AS, primarily among men with low health literacy. These findings have implications for our understanding of how prognostic molecular assays that generate probabilities of poor outcome can affect treatment decisions in diverse clinical populations.PMID:33835822 | DOI:10.1200/JCO.20.02997 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 9, 2021 Category: Cancer & Oncology Authors: Adam B Murphy Michael R Abern Li Liu Heidy Wang Courtney M P Hollowell Roohollah Sharifi Patricia Vidal Andre Kajdacsy-Balla Marin Sekosan Karen Ferrer Shoujin Wu Marlene Gallegos Patrice King-Lee Lisa K Sharp Carol E Ferrans Peter H Gann Source Type: research

GC-MS-based metabolomics reveals new biomarkers to assist the differentiation of prostate cancer and benign prostatic hyperplasia
In this study, we aimed to improve the diagnostic capability of the existing noninvasive biomarkers for PCa. GC-MS-based untargeted metabolomics was employed to analyze plasma samples for 41 PCa patients and 38 BPH controls. Both univariate and multivariate statistical analyses were performed to screen for differential metabolites between PCa and BPH, followed by the selection of potential biomarkers through machine learning. The chosen candidate biomarkers were then verified by targeted analysis and transcriptome data. The results showed that twelve metabolites were significantly dysregulated between PCa and BPH, three me...
Source: Clinical Prostate Cancer - April 8, 2021 Category: Cancer & Oncology Authors: Wenyu Wang Zhuoru He Yu Kong Zhongqiu Liu Lingzhi Gong Source Type: research

GC-MS-based metabolomics reveals new biomarkers to assist the differentiation of prostate cancer and benign prostatic hyperplasia
In this study, we aimed to improve the diagnostic capability of the existing noninvasive biomarkers for PCa. GC-MS-based untargeted metabolomics was employed to analyze plasma samples for 41 PCa patients and 38 BPH controls. Both univariate and multivariate statistical analyses were performed to screen for differential metabolites between PCa and BPH, followed by the selection of potential biomarkers through machine learning. The chosen candidate biomarkers were then verified by targeted analysis and transcriptome data. The results showed that twelve metabolites were significantly dysregulated between PCa and BPH, three me...
Source: Clinical Prostate Cancer - April 8, 2021 Category: Cancer & Oncology Authors: Wenyu Wang Zhuoru He Yu Kong Zhongqiu Liu Lingzhi Gong Source Type: research

Efficacy of Neoadjuvant Chemohormonal Therapy in Oligometastatic Hormone-Sensitive Prostate Cancer: A Prospective, Three-Arm, Comparative Propensity Score Match Analysis
Clin Genitourin Cancer. 2021 Feb 24:S1558-7673(21)00048-3. doi: 10.1016/j.clgc.2021.02.004. Online ahead of print.ABSTRACTBACKGROUND: The study aimed to investigate the efficacy and safety outcomes in hormone-sensitive oligometastatic prostate cancer (OMPC) patients treated with docetaxel-based neoadjuvant chemohormonal therapy (NCHT) prior to radical prostatectomy (RP) compared with direct RP and standard androgen deprivation therapy (ADT) alone using propensity score match (PSM) analysis.PATIENTS AND METHODS: A single-center, prospective, three-arm study was conducted with hormone-sensitive OMPC patients. Eligible patien...
Source: Clinical Prostate Cancer - April 7, 2021 Category: Cancer & Oncology Authors: Chenfei Chi Liancheng Fan Baijun Dong Yinjie Zhu Zhixiang Xin Jiahua Pan Wei Xue Source Type: research

Efficacy of Neoadjuvant Chemohormonal Therapy in Oligometastatic Hormone-Sensitive Prostate Cancer: A Prospective, Three-Arm, Comparative Propensity Score Match Analysis
Clin Genitourin Cancer. 2021 Feb 24:S1558-7673(21)00048-3. doi: 10.1016/j.clgc.2021.02.004. Online ahead of print.ABSTRACTBACKGROUND: The study aimed to investigate the efficacy and safety outcomes in hormone-sensitive oligometastatic prostate cancer (OMPC) patients treated with docetaxel-based neoadjuvant chemohormonal therapy (NCHT) prior to radical prostatectomy (RP) compared with direct RP and standard androgen deprivation therapy (ADT) alone using propensity score match (PSM) analysis.PATIENTS AND METHODS: A single-center, prospective, three-arm study was conducted with hormone-sensitive OMPC patients. Eligible patien...
Source: Clinical Prostate Cancer - April 7, 2021 Category: Cancer & Oncology Authors: Chenfei Chi Liancheng Fan Baijun Dong Yinjie Zhu Zhixiang Xin Jiahua Pan Wei Xue Source Type: research

Circulating tumor cell chromosomal instability and neuroendocrine phenotype by immunomorphology and poor outcomes in men with mCRPC treated with abiraterone or enzalutamide
CONCLUSIONS: A high chromosomal instability and neuroendocrine CTC phenotype is independently associated with worse survival in men with mCRPC treated with abi/enza, warranting further prospective controlled predictive studies to inform treatment decisions.PMID:33820782 | DOI:10.1158/1078-0432.CCR-20-3471 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 6, 2021 Category: Cancer & Oncology Authors: Landon C Brown Susan Halabi Joseph D Schonhoft Qian Yang Jun Luo David M Nanus Paraskevi Giannakakou Russell Z Szmulewitz Daniel C Danila Ethan S Barnett Emily A Carbone Jimmy L Zhao Patrick Healy Monika Anand Audrey Gill Adam Jendrisak William R Berry Sa Source Type: research

Natural Language Processing to Identify Cancer Treatments With Electronic Medical Records
CONCLUSION: Our results show that treatment identification using free-text clinical notes greatly improves upon the performance using billing codes and simple structured data. The approach can be used for treatment cohort identification and adapted for longitudinal cancer treatment identification.PMID:33822653 | DOI:10.1200/CCI.20.00173 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 6, 2021 Category: Cancer & Oncology Authors: Jiaming Zeng Imon Banerjee A Solomon Henry Douglas J Wood Ross D Shachter Michael F Gensheimer Daniel L Rubin Source Type: research

Predicting Outcomes in Men With Metastatic Nonseminomatous Germ Cell Tumors (NSGCT): Results From the IGCCCG Update Consortium
CONCLUSION: The IGCCCG Update model improves individual prognostication in metastatic nonseminomatous germ cell tumors. Increasing age and lung metastases add granularity to the original IGCCCG classification as adverse prognostic factors.PMID:33822655 | DOI:10.1200/JCO.20.03296 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 6, 2021 Category: Cancer & Oncology Authors: Silke Gillessen Nicolas Sauv é Laurence Collette Gedske Daugaard Ronald de Wit Costantine Albany Alexey Tryakin Karim Fizazi Olof Stahl Jourik A Gietema Ugo De Giorgi Fay H Cafferty Aaron R Hansen Torgrim Tandstad Robert A Huddart Andrea Necchi Christoph Source Type: research

Clinical characteristics, etiology, management and outcome of hematospermia: a systematic review
CONCLUSIONS: Hematospermia is relatively an innocent symptom. Malignancies are rare and occurred in men over 40 years. Clinical assessment including a rectal examination and a PSA level would be sufficient to identify most causes. Urogenital infections/inflammation and prostatic calculi are the commonly found etiologies. There was no identifiable cause in almost half of those with hematospermia. The majority has a benign course.PMID:33816690 | PMC:PMC8012833 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 5, 2021 Category: Cancer & Oncology Authors: Madhawa Madhushankha Umesh Jayarajah Anuruddha M Abeygunasekera Source Type: research

Platelet TSP-1 controls prostate cancer-induced osteoclast differentiation and bone marrow-derived cell mobilization through TGFbeta-1
Am J Clin Exp Urol. 2021 Feb 15;9(1):18-31. eCollection 2021.ABSTRACTThe development of distant metastasis is the leading cause of prostate cancer (CaP)-related death, with the skeleton being the primary site of metastasis. While the progression of primary tumors and the growth of bone metastatic tumors are well described, the mechanisms controlling pre-metastatic niche formation and homing of CaP to bone remain unclear. Through prior studies, we demonstrated that platelet secretion was required for ongoing tumor growth and pre-metastatic tumor-induced bone formation. Platelets stimulated bone marrow-derived cell (BMDC) mo...
Source: Clinical Prostate Cancer - April 5, 2021 Category: Cancer & Oncology Authors: Bethany A Kerr Koran S Harris Lihong Shi Jeffrey S Willey David R Soto-Pantoja Tatiana V Byzova Source Type: research

Claudin-1 down-regulation in the prostate is associated with aging and increased infiltration of inflammatory cells in BPH
CONCLUSIONS: These findings suggest that aging is associated with down-regulation of claudin-1 and claudin-1 is further decreased in BPH. Claudin-1 down-regulation was associated with increased infiltration of inflammatory cells in both NAP and BPH tissues. Claudin-1 down-regulation in the aging prostate could contribute to increased prostatic inflammation, subsequently contributing to BPH pathogenesis.PMID:33816694 | PMC:PMC8012836 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 5, 2021 Category: Cancer & Oncology Authors: Laura E Pascal Rajiv Dhir Goundappa K Balasubramani Wei Chen Chandler N Hudson Pooja Srivastava Anthony Green Donald B DeFranco Naoki Yoshimura Zhou Wang Source Type: research

The role of Trop2 in prostate cancer: an oncogene, biomarker, and therapeutic target
Am J Clin Exp Urol. 2021 Feb 15;9(1):73-87. eCollection 2021.ABSTRACTProstate cancer remains the second leading cause of cancer-associated deaths amongst American men. Trop2, a cell surface glycoprotein, correlates with poor clinical outcome and is highly expressed in metastatic, treatment-resistant prostate cancer. High levels of Trop2 are prognostic for biochemical recurrence. Trop2 regulates tumor growth and metastatic ability of prostate cancer. Moreover, overexpression of Trop2 drives the transdifferentiation to neuroendocrine phenotype in prostate cancer. In addition, Trop2 is overexpressed across epithelial cancers ...
Source: Clinical Prostate Cancer - April 5, 2021 Category: Cancer & Oncology Authors: Michelle Shen Shiqin Liu Tanya Stoyanova Source Type: research

The effect of the type of surgery performed due to prostate cancer on preoperative patient anxiety, a prospective study
CONCLUSION: Preoperative information about the surgical procedure was found to be an effective factor in reducing anxiety. Regardless of the type of surgery we recommend that patients' anxiety should be reduced by explaining the surgical procedure to patients enough and in a way that they can understand.PMID:33816697 | PMC:PMC8012827 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 5, 2021 Category: Cancer & Oncology Authors: Batuhan Ergani Mert Hamza Ozbilen Mehmet Yigit Yalc ın Hayal Boyac ıoglu Yusuf Ozlem Ilbey Source Type: research

Targeting treatment options for castration-resistant prostate cancer
Am J Clin Exp Urol. 2021 Feb 15;9(1):101-120. eCollection 2021.ABSTRACTProstate cancer (PCa) is the most commonly diagnosed solid tumor and the second leading cause of cancer-related deaths in U.S. men in 2020. Androgen-deprivation therapy (ADT) is the standard of care for metastatic PCa. Unfortunately, PCa relapse often occurs one to two years after initiation of ADT, resulting in the development of castration-resistant PCa (CRPCa), a lethal disease. While several anticancer agents such as docetaxel, abiraterone acetate, and enzalutamide are currently utilized to extend a patient's life after development of CRPCa, patient...
Source: Clinical Prostate Cancer - April 5, 2021 Category: Cancer & Oncology Authors: Dannah R Miller Matthew A Ingersoll Benjamin A Teply Ming-Fong Lin Source Type: research

E-cadherin expression is inversely correlated with aging and inflammation in the prostate
CONCLUSIONS: These findings suggest that aging is associated with down-regulation of E-cadherin and up-regulation of stromal COX-2 immunostaining in the prostate. E-cadherin immunostaining was inversely associated with age and inflammation, while stromal COX-2 immunostaining was positively associated with age and inflammation in the prostate. These findings suggest that the prostate epithelial barrier is altered and inflammation is increased with age in the prostate. These changes are further exacerbated in BPH, and may be involved in BPH pathogenesis.PMID:33816702 | PMC:PMC8012829 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 5, 2021 Category: Cancer & Oncology Authors: Laura E Pascal Rajiv Dhir Goundappa K Balasubramani Wei Chen Chandler N Hudson Pooja Srivastava Anthony Green Donald B DeFranco Naoki Yoshimura Zhou Wang Source Type: research

Transrectal ultrasound guided prostate biopsy performed by supervised junior and senior residents is safe and does not result in inferior outcomes
CONCLUSIONS: TRUSBx performed by residents and attending physicians yielded equivalent rates of cancer detection with no significant difference in 30-day complications or 30-day hospitalizations rates. There was no difference in outcomes between junior and senior residents suggesting that with adequate faculty supervision, it is safe for trainees at all levels to perform prostate biopsies.PMID:33816703 | PMC:PMC8012825 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 5, 2021 Category: Cancer & Oncology Authors: Jesse F Wang Margaret A Knoedler Kimberly A Maciolek Natasza M Posielski Vania Lopez Wade A Bushman Sara L Best Dan R Gralnek Kyle A Richards Source Type: research

Transrectal ultrasound guided prostate biopsy in university of Benin teaching hospital: effect of prostate volume on pain amongst Nigerian patients
This study assessed the effect of prostate volume on pain during TRUS guided prostate biopsy when apical peri-prostatic block is compared with intra-rectal xylocaine gel. This was a prospective randomized study which involved 90 patients. Group (A) had 2% intra-rectal plain xylocaine gel instillation, while Group (B) had peri-prostatic block with 1% plain xylocaine infiltration. Both groups were further stratified into prostate volume of
Source: Clinical Prostate Cancer - April 5, 2021 Category: Cancer & Oncology Authors: Ehiremhen Ozah Ekene V Ezenwa Jude O Agbugui Emmanuel O Osaigbovo Source Type: research

Clinical characteristics, etiology, management and outcome of hematospermia: a systematic review
CONCLUSIONS: Hematospermia is relatively an innocent symptom. Malignancies are rare and occurred in men over 40 years. Clinical assessment including a rectal examination and a PSA level would be sufficient to identify most causes. Urogenital infections/inflammation and prostatic calculi are the commonly found etiologies. There was no identifiable cause in almost half of those with hematospermia. The majority has a benign course.PMID:33816690 | PMC:PMC8012833 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 5, 2021 Category: Cancer & Oncology Authors: Madhawa Madhushankha Umesh Jayarajah Anuruddha M Abeygunasekera Source Type: research

Platelet TSP-1 controls prostate cancer-induced osteoclast differentiation and bone marrow-derived cell mobilization through TGFbeta-1
Am J Clin Exp Urol. 2021 Feb 15;9(1):18-31. eCollection 2021.ABSTRACTThe development of distant metastasis is the leading cause of prostate cancer (CaP)-related death, with the skeleton being the primary site of metastasis. While the progression of primary tumors and the growth of bone metastatic tumors are well described, the mechanisms controlling pre-metastatic niche formation and homing of CaP to bone remain unclear. Through prior studies, we demonstrated that platelet secretion was required for ongoing tumor growth and pre-metastatic tumor-induced bone formation. Platelets stimulated bone marrow-derived cell (BMDC) mo...
Source: Clinical Prostate Cancer - April 5, 2021 Category: Cancer & Oncology Authors: Bethany A Kerr Koran S Harris Lihong Shi Jeffrey S Willey David R Soto-Pantoja Tatiana V Byzova Source Type: research

Claudin-1 down-regulation in the prostate is associated with aging and increased infiltration of inflammatory cells in BPH
CONCLUSIONS: These findings suggest that aging is associated with down-regulation of claudin-1 and claudin-1 is further decreased in BPH. Claudin-1 down-regulation was associated with increased infiltration of inflammatory cells in both NAP and BPH tissues. Claudin-1 down-regulation in the aging prostate could contribute to increased prostatic inflammation, subsequently contributing to BPH pathogenesis.PMID:33816694 | PMC:PMC8012836 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 5, 2021 Category: Cancer & Oncology Authors: Laura E Pascal Rajiv Dhir Goundappa K Balasubramani Wei Chen Chandler N Hudson Pooja Srivastava Anthony Green Donald B DeFranco Naoki Yoshimura Zhou Wang Source Type: research

The role of Trop2 in prostate cancer: an oncogene, biomarker, and therapeutic target
Am J Clin Exp Urol. 2021 Feb 15;9(1):73-87. eCollection 2021.ABSTRACTProstate cancer remains the second leading cause of cancer-associated deaths amongst American men. Trop2, a cell surface glycoprotein, correlates with poor clinical outcome and is highly expressed in metastatic, treatment-resistant prostate cancer. High levels of Trop2 are prognostic for biochemical recurrence. Trop2 regulates tumor growth and metastatic ability of prostate cancer. Moreover, overexpression of Trop2 drives the transdifferentiation to neuroendocrine phenotype in prostate cancer. In addition, Trop2 is overexpressed across epithelial cancers ...
Source: Clinical Prostate Cancer - April 5, 2021 Category: Cancer & Oncology Authors: Michelle Shen Shiqin Liu Tanya Stoyanova Source Type: research

The effect of the type of surgery performed due to prostate cancer on preoperative patient anxiety, a prospective study
CONCLUSION: Preoperative information about the surgical procedure was found to be an effective factor in reducing anxiety. Regardless of the type of surgery we recommend that patients' anxiety should be reduced by explaining the surgical procedure to patients enough and in a way that they can understand.PMID:33816697 | PMC:PMC8012827 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 5, 2021 Category: Cancer & Oncology Authors: Batuhan Ergani Mert Hamza Ozbilen Mehmet Yigit Yalc ın Hayal Boyac ıoglu Yusuf Ozlem Ilbey Source Type: research

Targeting treatment options for castration-resistant prostate cancer
Am J Clin Exp Urol. 2021 Feb 15;9(1):101-120. eCollection 2021.ABSTRACTProstate cancer (PCa) is the most commonly diagnosed solid tumor and the second leading cause of cancer-related deaths in U.S. men in 2020. Androgen-deprivation therapy (ADT) is the standard of care for metastatic PCa. Unfortunately, PCa relapse often occurs one to two years after initiation of ADT, resulting in the development of castration-resistant PCa (CRPCa), a lethal disease. While several anticancer agents such as docetaxel, abiraterone acetate, and enzalutamide are currently utilized to extend a patient's life after development of CRPCa, patient...
Source: Clinical Prostate Cancer - April 5, 2021 Category: Cancer & Oncology Authors: Dannah R Miller Matthew A Ingersoll Benjamin A Teply Ming-Fong Lin Source Type: research

E-cadherin expression is inversely correlated with aging and inflammation in the prostate
CONCLUSIONS: These findings suggest that aging is associated with down-regulation of E-cadherin and up-regulation of stromal COX-2 immunostaining in the prostate. E-cadherin immunostaining was inversely associated with age and inflammation, while stromal COX-2 immunostaining was positively associated with age and inflammation in the prostate. These findings suggest that the prostate epithelial barrier is altered and inflammation is increased with age in the prostate. These changes are further exacerbated in BPH, and may be involved in BPH pathogenesis.PMID:33816702 | PMC:PMC8012829 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 5, 2021 Category: Cancer & Oncology Authors: Laura E Pascal Rajiv Dhir Goundappa K Balasubramani Wei Chen Chandler N Hudson Pooja Srivastava Anthony Green Donald B DeFranco Naoki Yoshimura Zhou Wang Source Type: research

Transrectal ultrasound guided prostate biopsy performed by supervised junior and senior residents is safe and does not result in inferior outcomes
CONCLUSIONS: TRUSBx performed by residents and attending physicians yielded equivalent rates of cancer detection with no significant difference in 30-day complications or 30-day hospitalizations rates. There was no difference in outcomes between junior and senior residents suggesting that with adequate faculty supervision, it is safe for trainees at all levels to perform prostate biopsies.PMID:33816703 | PMC:PMC8012825 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 5, 2021 Category: Cancer & Oncology Authors: Jesse F Wang Margaret A Knoedler Kimberly A Maciolek Natasza M Posielski Vania Lopez Wade A Bushman Sara L Best Dan R Gralnek Kyle A Richards Source Type: research

Transrectal ultrasound guided prostate biopsy in university of Benin teaching hospital: effect of prostate volume on pain amongst Nigerian patients
This study assessed the effect of prostate volume on pain during TRUS guided prostate biopsy when apical peri-prostatic block is compared with intra-rectal xylocaine gel. This was a prospective randomized study which involved 90 patients. Group (A) had 2% intra-rectal plain xylocaine gel instillation, while Group (B) had peri-prostatic block with 1% plain xylocaine infiltration. Both groups were further stratified into prostate volume of
Source: Clinical Prostate Cancer - April 5, 2021 Category: Cancer & Oncology Authors: Ehiremhen Ozah Ekene V Ezenwa Jude O Agbugui Emmanuel O Osaigbovo Source Type: research

Nomograms in Urologic Oncology: Lights and Shadows
J Clin Med. 2021 Mar 2;10(5):980. doi: 10.3390/jcm10050980.ABSTRACTDecision-making in urologic oncology involves integrating multiple clinical data to provide an answer to the needs of a single patient. Although the practice of medicine has always been an "art" involving experience, clinical data, scientific evidence and judgment, the creation of specialties and subspecialties has multiplied the challenges faced every day by physicians. In the last decades, with the field of urologic oncology becoming more and more complex, there has been a rise in tools capable of compounding several pieces of information and su...
Source: Clinical Prostate Cancer - April 3, 2021 Category: Cancer & Oncology Authors: Alessandro Morlacco Daniele Modonutti Giovanni Motterle Francesca Martino Fabrizio Dal Moro Giacomo Novara Source Type: research

Head-to-Head Comparison of Two Nomograms Predicting Probability of Lymph Node Invasion in Prostate Cancer and the Therapeutic Impact of Higher Nomogram Threshold
Conclusions: Both analysed nomograms demonstrated high accuracy for prediction of LNI. Using a 7% nomogram cut-off would allow the avoidance up to 47% of PLNDs, while missing less than 4% of patients with LNI.PMID:33801231 | DOI:10.3390/jcm10050999 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 3, 2021 Category: Cancer & Oncology Authors: Zilvinas Venclovas Tim Muilwijk Aivaras J Matjosaitis Mindaugas Jievaltas Steven Joniau Daimantas Milonas Source Type: research

Tau oligomers accumulation sensitizes prostate cancer cells to docetaxel treatment
CONCLUSIONS: Our data indicate that autophagy could exert a promoting role in cancer growth and during chemotherapy facilitating degradation of tau protein and thus blocking the antimitotic effect of accumulated tau oligomers. Thus, therapeutic strategies aimed at stimulating tau oligomers formation, such as autophagy inhibition, could be an effective adjuvant in cancer therapy.PMID:33811272 | DOI:10.1007/s00432-021-03598-3 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 3, 2021 Category: Cancer & Oncology Authors: Stefano Martellucci Letizia Clementi Samantha Sabetta Paola Muzi Vincenzo Mattei Mauro Bologna Adriano Angelucci Source Type: research

Nomograms in Urologic Oncology: Lights and Shadows
J Clin Med. 2021 Mar 2;10(5):980. doi: 10.3390/jcm10050980.ABSTRACTDecision-making in urologic oncology involves integrating multiple clinical data to provide an answer to the needs of a single patient. Although the practice of medicine has always been an "art" involving experience, clinical data, scientific evidence and judgment, the creation of specialties and subspecialties has multiplied the challenges faced every day by physicians. In the last decades, with the field of urologic oncology becoming more and more complex, there has been a rise in tools capable of compounding several pieces of information and su...
Source: Clinical Prostate Cancer - April 3, 2021 Category: Cancer & Oncology Authors: Alessandro Morlacco Daniele Modonutti Giovanni Motterle Francesca Martino Fabrizio Dal Moro Giacomo Novara Source Type: research

Head-to-Head Comparison of Two Nomograms Predicting Probability of Lymph Node Invasion in Prostate Cancer and the Therapeutic Impact of Higher Nomogram Threshold
Conclusions: Both analysed nomograms demonstrated high accuracy for prediction of LNI. Using a 7% nomogram cut-off would allow the avoidance up to 47% of PLNDs, while missing less than 4% of patients with LNI.PMID:33801231 | DOI:10.3390/jcm10050999 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 3, 2021 Category: Cancer & Oncology Authors: Zilvinas Venclovas Tim Muilwijk Aivaras J Matjosaitis Mindaugas Jievaltas Steven Joniau Daimantas Milonas Source Type: research