Efficacy and safety of anti-hepatic fibrosis drugs.
Abstract Recent progress in our understanding of the pathways linked to progression from hepatic insult to cirrhosis has led to numerous novel therapies being investigated as potential cures and inhibitors of hepatic fibrogenesis. Liver cirrhosis is the final result of prolonged fibrosis, which is an intimate balance between fibrogenesis and fibrinolysis. A number of these complex mechanisms are shared across the various etiologies of liver disease. Thankfully, investigation has yielded some promising results in regard to reversal of fibrosis, particularly the indirect benefits associated with antiviral therapy fo...
Source: World Journal of Gastroenterology : WJG - November 7, 2020 Category: Gastroenterology Authors: Damiris K, Tafesh ZH, Pyrsopoulos N Tags: World J Gastroenterol Source Type: research

Focus on gastroesophageal reflux disease in patients with cystic fibrosis.
rdi S Abstract Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder in cystic fibrosis (CF), and based on various studies, its prevalence is elevated since childhood. There are several pathogenetic mechanisms on the basis of association between CF and GERD. However, there are no specific guidelines for GERD in CF patients, so diagnosis is based on guidelines performed on patients not affected by CF. The aim of this review is to provide the pathophysiology, diagnostic and therapeutic options, complications, and future directions in the management of GERD patients with CF. PMID: 33244195...
Source: World Journal of Gastroenterology : WJG - November 7, 2020 Category: Gastroenterology Authors: Bongiovanni A, Manti S, Parisi GF, Papale M, Mulè E, Rotolo N, Leonardi S Tags: World J Gastroenterol Source Type: research

Origin and genomic characteristics of SARS-CoV-2 and its interaction with angiotensin converting enzyme type 2 receptors, focusing on the gastrointestinal tract.
Abstract The emergence of coronavirus disease-2019 induced by a newly identified b-coronavirus, namely severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has constituted a public health emergency. Even though it was considered a zoonotic disease, the virus has also spread among humans via respiratory secretions. The expression and distribution of angiotensin converting enzyme type 2 (ACE2) in various human organs might also show other possible infection routes. High ACE2 ribonucleic acid expression has been identified in the gastrointestinal tract (GI) indicating its importance as a possible infection pa...
Source: World Journal of Gastroenterology : WJG - November 7, 2020 Category: Gastroenterology Authors: Galanopoulos M, Doukatas A, Gazouli M Tags: World J Gastroenterol Source Type: research

Dihydromyricetin ameliorates chronic liver injury by reducing pyroptosis.
CONCLUSION: DHM improves CCl4-induced CLI and regulates the pyroptosis pathway in hepatocytes. DHM may be a potential therapeutic agent for CLI. PMID: 33244197 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 7, 2020 Category: Gastroenterology Authors: Cheng QC, Fan J, Deng XW, Liu HC, Ding HR, Fang X, Wang JW, Chen CH, Zhang WG Tags: World J Gastroenterol Source Type: research

P-selectin glycoprotein ligand 1 deficiency prevents development of acute pancreatitis by attenuating leukocyte infiltration.
CONCLUSION: PSGL-1 deficiency effectively inhibits the development of AP by preventing leukocyte-endothelial cell adhesion via IL-6 stimulation and may become a potential therapeutic target for treating AP. PMID: 33244198 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 7, 2020 Category: Gastroenterology Authors: Zhang X, Zhu M, Jiang XL, Liu X, Liu X, Liu P, Wu XX, Yang ZW, Qin T Tags: World J Gastroenterol Source Type: research

Associations of content and gene polymorphism of macrophage inhibitory factor-1 and chronic hepatitis C virus infection.
Abstract BACKGROUND: The expression of macrophage inhibitory factor-1 (MIC-1) is increased in peripheral blood of patients with chronic hepatitis and liver cirrhosis. However, whether MIC-1 gene polymorphism is correlated with relevant diseases is not yet reported. AIM: To explore the correlation between gene polymorphism in MIC-1 exon region and chronic hepatitis C virus (HCV) infection. METHODS: This case-control study enrolled 178 patients with chronic hepatitis C (CHC) in the case group, and 82 healthy subjects from the same region who had passed the screening examination comprised the control group....
Source: World Journal of Gastroenterology : WJG - November 7, 2020 Category: Gastroenterology Authors: Yang XJ, Wang XO, Chen Y, Ye SD Tags: World J Gastroenterol Source Type: research

Escalating complexity of endoscopic retrograde cholangiopancreatography over the last decade with increasing reliance on advanced cannulation techniques.
Abstract BACKGROUND: At our academic tertiary care medical center, we have noted patients referred for endoscopic retrograde cholangiopancreatography (ERCP) who increasingly require advanced cannulation techniques. This trend is noted despite increased endoscopist experience and annual ERCP volume over the same period. AIM: To evaluate this phenomenon of perceived escalation in complexity of cannulation at ERCP and assessed potential underlying factors. METHODS: Demographic/clinical variables and records of ERCP patients at the beginning (2008), middle (2013) and end (2018) of the last decade were review...
Source: World Journal of Gastroenterology : WJG - November 7, 2020 Category: Gastroenterology Authors: Barakat MT, Girotra M, Thosani N, Kothari S, Banerjee S Tags: World J Gastroenterol Source Type: research

Older age, longer procedures and tandem endoscopic-ultrasound as risk factors for post-endoscopic retrograde cholangiopancreatography bacteremia.
Abstract BACKGROUND: Clinically significant post-endoscopic retrograde cholangiopancreatography (ERCP) bacteremia (PEB) occurs in up to 5% of cases, while antibiotic prophylaxis is recommended only when an ERCP is unlikely to achieve complete biliary drainage. However, the current recommendations may not cover all potential risk factors for PEB. AIM: To identify novel risk factors for PEB and evaluate appropriateness of antibiotic prophylaxis. METHODS: A retrospective study of 1082 ERCP procedures performed between January 2012 - December 2013 in a single tertiary medical center. Data collection included...
Source: World Journal of Gastroenterology : WJG - November 7, 2020 Category: Gastroenterology Authors: Deutsch L, Matalon S, Phillips A, Leshno M, Shibolet O, Santo E Tags: World J Gastroenterol Source Type: research

Signature based on molecular subtypes of deoxyribonucleic acid methylation predicts overall survival in gastric cancer.
Abstract BACKGROUND: Gastric cancer (GC) ranks as the third leading cause of cancer-related death worldwide. Epigenetic alterations contribute to tumor heterogeneity in early stages. AIM: To identify the specific deoxyribonucleic acid (DNA) methylation sites that influence the prognosis of GC patients and explore the prognostic value of a model based on subtypes of DNA methylation. METHODS: Patients were randomly classified into training and test sets. Prognostic DNA methylation sites were identified by integrating DNA methylation profiles and clinical data from The Cancer Genome Atlas GC cohort. In the ...
Source: World Journal of Gastroenterology : WJG - November 7, 2020 Category: Gastroenterology Authors: Bian J, Long JY, Yang X, Yang XB, Xu YY, Lu X, Sang XT, Zhao HT Tags: World J Gastroenterol Source Type: research

Endoscopic gastric fenestration of debriding pancreatic walled-off necrosis: A pilot study.
CONCLUSION: EGF is an innovative and promising alternative intervention for WON adherent to the gastric wall. The challenge resides in the gauging of actual adherence and in selecting appropriate fenestration sites. PMID: 33244203 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 7, 2020 Category: Gastroenterology Authors: Liu F, Wu L, Wang XD, Xiao JG, Li W Tags: World J Gastroenterol Source Type: research

Ischemic colitis after enema administration: Incidence, timing, and clinical features.
CONCLUSION: The incidence of glycerin enema-related IC was 0.23% and occurred mostly in the elderly in the early period following enema administration. Glycerin enema-related IC was associated with the constipation score and leukocytosis. PMID: 33244204 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 7, 2020 Category: Gastroenterology Authors: Ahn Y, Hong GS, Lee JH, Lee CW, Kim SO Tags: World J Gastroenterol Source Type: research

Real-world cost-effectiveness associated with infliximab maintenance therapy for moderate to severe Crohn's disease in China.
CONCLUSION: IMT significantly improved real-world health outcomes and cost the Chinese public health insurance payers less than one GDPPC to gain one QALY in Chinese MS-CD patients. PMID: 33244205 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 7, 2020 Category: Gastroenterology Authors: Shi JH, Luo L, Chen XL, Pan YP, Zhang Z, Fang H, Chen Y, Chen WD, Cao Q Tags: World J Gastroenterol Source Type: research

Third-look endoscopy prevents delayed bleeding after endoscopic submucosal dissection under antithrombotic therapy.
Abstract BACKGROUND: Postoperative delayed bleeding (PDB) after gastric endoscopic submucosal dissection (ESD) is the most common adverse event in patients receiving antithrombotics even with second-look endoscopy. Moreover, with the increasing prevalence of cardiovascular and cerebrovascular diseases in an aging population with associated lifestyle-related diseases, an increasing number of patients receive antithrombotics. Several attempts have been made to prevent PDB in aging population; however, a consensus has yet to be reached. AIM: To examine the efficacy of third-look endoscopy (TLE) for PDB preventio...
Source: World Journal of Gastroenterology : WJG - November 7, 2020 Category: Gastroenterology Authors: Ikeda R, Hirasawa K, Sato C, Ozeki Y, Sawada A, Nishio M, Fukuchi T, Kobayashi R, Makazu M, Taguri M, Maeda S Tags: World J Gastroenterol Source Type: research

Efficacy and safety of non-pharmacological interventions for irritable bowel syndrome in adults.
CONCLUSION: This study confirmed the efficacy and safety of NPI for improving IBS symptoms, which to some extent recommended several interventions for clinical practice. PMID: 33244207 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 7, 2020 Category: Gastroenterology Authors: Dai YK, Wu YB, Li RL, Chen WJ, Tang CZ, Lu LM, Hu L Tags: World J Gastroenterol Source Type: research

Comment on "Updated meta-analysis of pancreatic stent placement in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis".
Comment on "Updated meta-analysis of pancreatic stent placement in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis". World J Gastroenterol. 2020 Nov 07;26(41):6510-6513 Authors: Chu JT Abstract I read with interest an article "Updated meta-analysis of pancreatic stent placement in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis" by Fan and colleagues in World J Gastroenterol 2015; 21(24): 7577-7583. Although I appreciate their work, I have found problems with the data extracted and analyzed by the authors, and will give my com...
Source: World Journal of Gastroenterology : WJG - November 7, 2020 Category: Gastroenterology Authors: Chu JT Tags: World J Gastroenterol Source Type: research

Cirrhotic portal hypertension: From pathophysiology to novel therapeutics.
Abstract Portal hypertension and bleeding from gastroesophageal varices is the major cause of morbidity and mortality in patients with cirrhosis. Portal hypertension is initiated by increased intrahepatic vascular resistance and a hyperdynamic circulatory state. The latter is characterized by a high cardiac output, increased total blood volume and splanchnic vasodilatation, resulting in increased mesenteric blood flow. Pharmacological manipulation of cirrhotic portal hypertension targets both the splanchnic and hepatic vascular beds. Drugs such as angiotensin converting enzyme inhibitors and angiotensin II type re...
Source: World Journal of Gastroenterology : WJG - October 28, 2020 Category: Gastroenterology Authors: Gunarathne LS, Rajapaksha H, Shackel N, Angus PW, Herath CB Tags: World J Gastroenterol Source Type: research

Role of gut microbiota via the gut-liver-brain axis in digestive diseases.
Abstract The gut-brain axis is a bidirectional information interaction system between the central nervous system (CNS) and the gastrointestinal tract, in which gut microbiota plays a key role. The gut microbiota forms a complex network with the enteric nervous system, the autonomic nervous system, and the neuroendocrine and neuroimmunity of the CNS, which is called the microbiota-gut-brain axis. Due to the close anatomical and functional interaction of the gut-liver axis, the microbiota-gut-liver-brain axis has attracted increased attention in recent years. The microbiota-gut-liver-brain axis mediates the occurren...
Source: World Journal of Gastroenterology : WJG - October 28, 2020 Category: Gastroenterology Authors: Ding JH, Jin Z, Yang XX, Lou J, Shan WX, Hu YX, Du Q, Liao QS, Xie R, Xu JY Tags: World J Gastroenterol Source Type: research

Imaging-based algorithmic approach to gallbladder wall thickening.
Abstract Gallbladder (GB) wall thickening is a frequent finding caused by a spectrum of conditions. It is observed in many extracholecystic as well as intrinsic GB conditions. GB wall thickening can either be diffuse or focal. Diffuse wall thickening is a secondary occurrence in both extrinsic and intrinsic pathologies of GB, whereas, focal wall thickening is mostly associated with intrinsic GB pathologies. In the absence of specific clinical features, accurate etiological diagnosis can be challenging. The survival rate in GB carcinoma (GBC) can be improved if it is diagnosed at an early stage, especially when the...
Source: World Journal of Gastroenterology : WJG - October 28, 2020 Category: Gastroenterology Authors: Gupta P, Marodia Y, Bansal A, Kalra N, Kumar-M P, Sharma V, Dutta U, Sandhu MS Tags: World J Gastroenterol Source Type: research

Overlooked risk for needle tract seeding following endoscopic ultrasound-guided minimally invasive tissue acquisition.
Abstract Endoscopic ultrasound-guided minimally invasive tissue acquisition can be performed by two approaches as follows: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB). These have been evolved into leading approaches and widely used for the histological diagnosis of tumors in the gastrointestinal tract and adjacent organs. However, the role of EUS-FNA and EUS-FNB in disease diagnosis and evaluation remains controversial. Although the incidence of surgery-associated complications remains low, the consequences of needle tract seeding can ...
Source: World Journal of Gastroenterology : WJG - October 28, 2020 Category: Gastroenterology Authors: Gao RY, Wu BH, Shen XY, Peng TL, Li DF, Wei C, Yu ZC, Luo MH, Xiong F, Wang LS, Yao J Tags: World J Gastroenterol Source Type: research

Prevalence, diagnosis, and treatment of primary hepatic gastrointestinal stromal tumors.
Abstract Gastrointestinal stromal tumors (GIST), which is the most common mesenchymal tumor of the digestive tract, account for 1%-3% of gastrointestinal tumors. Primary stromal tumors outside the gastrointestinal tract are collectively referred to as extra GISTs, and stromal tumors in different regions often have different prognoses. A primary hepatic GIST is a rare tumor with an unknown origin, which may be related to interstitial Cajal-like cells. Although primary hepatic GIST has certain characteristics on imaging, it lacks specific symptoms and signs; thus, the final diagnosis depends on pathological and gene...
Source: World Journal of Gastroenterology : WJG - October 28, 2020 Category: Gastroenterology Authors: Qian XH, Yan YC, Gao BQ, Wang WL Tags: World J Gastroenterol Source Type: research

Prediction of clinically actionable genetic alterations from colorectal cancer histopathology images using deep learning.
CONCLUSION: APC, KRAS, PIK3CA, SMAD4, and TP53 mutations can be predicted from H&E pathology images using deep learning-based classifiers, demonstrating the potential for deep learning-based mutation prediction in the CRC tissue slides. PMID: 33177794 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 28, 2020 Category: Gastroenterology Authors: Jang HJ, Lee A, Kang J, Song IH, Lee SH Tags: World J Gastroenterol Source Type: research

New strain of Pediococcus pentosaceus alleviates ethanol-induced liver injury by modulating the gut microbiota and short-chain fatty acid metabolism.
CONCLUSION: Based on these results, the new strain of P. pentosaceus alleviated ethanol-induced liver injury by reversing gut microbiota dysbiosis, regulating intestinal SCFA metabolism, improving intestinal barrier function, and reducing circulating levels of endotoxin and proinflammatory cytokines and chemokines. Thus, this strain is a potential probiotic treatment for ALD. PMID: 33177795 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 28, 2020 Category: Gastroenterology Authors: Jiang XW, Li YT, Ye JZ, Lv LX, Yang LY, Bian XY, Wu WR, Wu JJ, Shi D, Wang Q, Fang DQ, Wang KC, Wang QQ, Lu YM, Xie JJ, Li LJ Tags: World J Gastroenterol Source Type: research

Predicting cholecystocholedochal fistulas in patients with Mirizzi syndrome undergoing endoscopic retrograde cholangiopancreatography.
Abstract BACKGROUND: Mirizzi syndrome (MS) is defined as an extrinsic compression of the extrahepatic biliary system by an impacted stone in the gallbladder or the cystic duct leading to obstructive jaundice. Endoscopic retrograde cholangiopancreatography (ERCP) could serve diagnostic and therapeutic purposes in patients with MS in addition to revealing the relationships between the cystic duct, the gallbladder, and the common bile duct (CBD). Cholecystectomy is a challenging procedure for a laparoscopic surgeon in patients with MS, and the presence of a cholecystocholedochal fistula renders preoperative diagnosis...
Source: World Journal of Gastroenterology : WJG - October 28, 2020 Category: Gastroenterology Authors: Wu CH, Liu NJ, Yeh CN, Wang SY, Jan YY Tags: World J Gastroenterol Source Type: research

Novel endoscopic papillectomy for reducing postoperative adverse events (with videos).
CONCLUSION: Patients who underwent the novel procedure had lower postoperative adverse event rates. This study demonstrates the potential efficacy and safety of the novel endoscopic papillectomy in reducing postoperative adverse events. PMID: 33177797 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 28, 2020 Category: Gastroenterology Authors: Jiang L, Ling-Hu EQ, Chai NL, Li W, Cai FC, Li MY, Guo X, Meng JY, Wang XD, Tang P, Zhu J, Du H, Wang HB Tags: World J Gastroenterol Source Type: research

Pediatric bowel preparation: Sodium picosulfate, magnesium oxide, citric acid vs polyethylene glycol, a randomized trial.
CONCLUSION: SPMC was an efficacious and safe for bowel preparation in children 9-16 years, with comparable efficacy to PEG. Tolerability for SPMC was higher compared to PEG. PMID: 33177798 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 28, 2020 Category: Gastroenterology Authors: Cuffari C, Ciciora SL, Ando M, Boules M, Croffie JM Tags: World J Gastroenterol Source Type: research

Insufficient etiological workup of COVID-19-associated acute pancreatitis: A systematic review.
CONCLUSION: We strongly highlight the need for adherence to the guidelines during a diagnostic and etiological workup, which could alter therapy. PMID: 33177799 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 28, 2020 Category: Gastroenterology Authors: Juhász MF, Ocskay K, Kiss S, Hegyi P, Párniczky A Tags: World J Gastroenterol Source Type: research

Diagnostic efficacy of the Japan Narrow-band-imaging Expert Team and Pit pattern classifications for colorectal lesions: A meta-analysis.
CONCLUSION: This meta-analysis suggests that the diagnostic efficacy of the JNET classification may be equivalent to that of the Pit pattern classification. However, due to its simpler and clearer clinical application, the JNET classification should be promoted for the classification of colorectal lesions, and to guide the treatment strategy. PMID: 33177800 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 28, 2020 Category: Gastroenterology Authors: Zhang Y, Chen HY, Zhou XL, Pan WS, Zhou XX, Pan HH Tags: World J Gastroenterol Source Type: research

Compromised therapeutic value of pediatric liver transplantation in ethylmalonic encephalopathy: A case report.
CONCLUSION: LT may bring about a partial but not complete cure to EE. Given its definite role in defending against the devastating natural progression of EE, LT should still be considered for patients with EE in the absence of other superior therapeutic options. Early establishment of diagnosis and initiation of conventional treatment pre-transplant, timely LT, and continuous administration of metabolism-correcting medications post-transplant may be helpful in minimizing the neurologic impairment and maximizing the therapeutic value of LT in EE. PMID: 33177801 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 28, 2020 Category: Gastroenterology Authors: Zhou GP, Qu W, Zhu ZJ, Sun LY, Wei L, Zeng ZG, Liu Y Tags: World J Gastroenterol Source Type: research

Use of artificial intelligence in improving adenoma detection rate during colonoscopy: Might both endoscopists and pathologists be further helped.
Abstract Colonoscopy remains the standard strategy for screening for colorectal cancer around the world due to its efficacy in both detecting adenomatous or pre-cancerous lesions and the capacity to remove them intra-procedurally. Computer-aided detection and diagnosis (CAD), thanks to the brand new developed innovations of artificial intelligence, and especially deep-learning techniques, leads to a promising solution to human biases in performance by guarantying decision support during colonoscopy. The application of CAD on real-time colonoscopy helps increasing the adenoma detection rate, and therefore contribut...
Source: World Journal of Gastroenterology : WJG - October 21, 2020 Category: Gastroenterology Authors: Sinagra E, Badalamenti M, Maida M, Spadaccini M, Maselli R, Rossi F, Conoscenti G, Raimondo D, Pallio S, Repici A, Anderloni A Tags: World J Gastroenterol Source Type: research

Clinical assessment and management of liver fibrosis in non-alcoholic fatty liver disease.
iacute;as-Rodríguez RU Abstract Non-alcoholic fatty liver disease (NAFLD) is among the most frequent etiologies of cirrhosis worldwide, and it is associated with features of metabolic syndrome; the key factor influencing its prognosis is the progression of liver fibrosis. This review aimed to propose a practical and stepwise approach to the evaluation and management of liver fibrosis in patients with NAFLD, analyzing the currently available literature. In the assessment of NAFLD patients, it is important to identify clinical, genetic, and environmental determinants of fibrosis development and its progressio...
Source: World Journal of Gastroenterology : WJG - October 21, 2020 Category: Gastroenterology Authors: Campos-Murguía A, Ruiz-Margáin A, González-Regueiro JA, Macías-Rodríguez RU Tags: World J Gastroenterol Source Type: research

Enteroscopy in children and adults with inflammatory bowel disease.
Abstract Inflammatory bowel disease (IBD) includes Crohn's disease (CD), ulcerative colitis and unclassified entities. CD commonly involves the terminal ileum and colon but at the time of diagnosis it can be confined to the small bowel (SB) in about 30% of the patients, especially in the young ones. Management of isolated SB-CD can be challenging and objective evaluation of the SB mucosa is essential in differentiating CD from other enteropathies to achieve therapeutic decisions and to plan the follow-up. The introduction of cross-sectional imaging techniques and capsule endoscopy (CE) have significantly expanded ...
Source: World Journal of Gastroenterology : WJG - October 21, 2020 Category: Gastroenterology Authors: Nardo GD, Esposito G, Ziparo C, Micheli F, Masoni L, Villa MP, Parisi P, Manca MB, Baccini F, Corleto VD Tags: World J Gastroenterol Source Type: research

Artificial intelligence technique in detection of early esophageal cancer.
Abstract Due to the rapid progression and poor prognosis of esophageal cancer (EC), the early detection and diagnosis of early EC are of great value for the prognosis improvement of patients. However, the endoscopic detection of early EC, especially Barrett's dysplasia or squamous epithelial dysplasia, is difficult. Therefore, the requirement for more efficient methods of detection and characterization of early EC has led to intensive research in the field of artificial intelligence (AI). Deep learning (DL) has brought about breakthroughs in processing images, videos, and other aspects, whereas convolutional neura...
Source: World Journal of Gastroenterology : WJG - October 21, 2020 Category: Gastroenterology Authors: Huang LM, Yang WJ, Huang ZY, Tang CW, Li J Tags: World J Gastroenterol Source Type: research

Polyethylene glycol 35 ameliorates pancreatic inflammatory response in cerulein-induced acute pancreatitis in rats.
CONCLUSION: PEG35 ameliorates pancreatic damage in cerulein-induced AP and AR42J-treated cells through the attenuation of the inflammatory response and associated cell death. PEG35 may be a valuable option in the management of AP. PMID: 33132648 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2020 Category: Gastroenterology Authors: Ferrero-Andrés A, Panisello-Roselló A, Roselló-Catafau J, Folch-Puy E Tags: World J Gastroenterol Source Type: research

Identification of differentially expressed genes in ulcerative colitis and verification in a colitis mouse model by bioinformatics analyses.
CONCLUSION: Core DEGs identified in UC are related to inflammation and immunity inflammation, indicating that these reactions are core features of the pathogenesis of UC. CXCR2 may reflect the degree of inflammation in patients with UC. PMID: 33132649 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2020 Category: Gastroenterology Authors: Shi L, Han X, Li JX, Liao YT, Kou FS, Wang ZB, Shi R, Zhao XJ, Sun ZM, Hao Y Tags: World J Gastroenterol Source Type: research

Herbal cake-partitioned moxibustion inhibits colonic autophagy in Crohn's disease via signaling involving distinct classes of phosphatidylinositol 3-kinases.
Abstract BACKGROUND: Autophagy is an evolutionarily conserved biological process in eukaryotic cells that involves lysosomal-mediated degradation and recycling of related cellular components. Recent studies have shown that autophagy plays an important role in the pathogenesis of Crohn's disease (CD). Herbal cake-partitioned moxibustion (HM) has been historically practiced to treat CD. However, the mechanism by which HM regulates colonic autophagy in CD remains unclear. AIM: To observe whether HM can alleviate CD by regulating colonic autophagy and to elucidate the underlying mechanism. METHODS: Rats were...
Source: World Journal of Gastroenterology : WJG - October 21, 2020 Category: Gastroenterology Authors: Wang SY, Zhao JM, Zhou CL, Zheng HD, Huang Y, Zhao M, Zhang ZY, Wu LY, Wu HG, Liu HR Tags: World J Gastroenterol Source Type: research

Single access laparoscopic total colectomy for severe refractory ulcerative colitis.
CONCLUSION: Single port total colectomy proved useful in planned and acute settings for patients with medically refractory colitis. Assumptions regarding duration and cost should not be barriers to its implementation. PMID: 33132651 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2020 Category: Gastroenterology Authors: Burke J, Toomey D, Reilly F, Cahill R Tags: World J Gastroenterol Source Type: research

Real-world treatment attrition rates in advanced esophagogastric cancer.
Abstract BACKGROUND: Over the last decade, multiple agents have demonstrated efficacy for advanced esophagogastric cancer (EGC). Despite the availability of later lines of therapy, there remains limited real-world data about the treatment attrition rates between lines of therapy. AIM: To characterize the use and attrition rates between lines of therapy for patients with advanced EGC. METHODS: We identified patients who received at least one cycle of chemotherapy for advanced EGC between July 1, 2017 and July 31, 2018 across six regional centers in British Columbia (BC), Canada. Clinicopathologic, treatme...
Source: World Journal of Gastroenterology : WJG - October 21, 2020 Category: Gastroenterology Authors: Tsang ES, Lim HJ, Renouf DJ, Davies JM, Loree JM, Gill S Tags: World J Gastroenterol Source Type: research

Metastatic pattern in esophageal and gastric cancer: Influenced by site and histology.
CONCLUSION: This study showed differences in metastatic patterns of patients with esophageal and gastric cancer according to the primary tumor location and histological subtype. PMID: 33132653 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2020 Category: Gastroenterology Authors: Verstegen MH, Harker M, van de Water C, van Dieren J, Hugen N, Nagtegaal ID, Rosman C, van der Post RS Tags: World J Gastroenterol Source Type: research

Relationships of early esophageal cancer with human papillomavirus and alcohol metabolism.
CONCLUSION: In the present situation, HPV status is considered to be less important than other risk factors, such as alcohol consumption, smoking habit, ADH1B/ALDH2 polymorphisms, and HPV status would therefore have no effect on ESCC risk management. PMID: 33132654 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2020 Category: Gastroenterology Authors: Inoue M, Shimizu Y, Ishikawa M, Abiko S, Shimoda Y, Tanaka I, Kinowaki S, Ono M, Yamamoto K, Ono S, Sakamoto N Tags: World J Gastroenterol Source Type: research

Dynamic contrast-enhanced magnetic resonance imaging and diffusion-weighted imaging in the activity staging of terminal ileum Crohn's disease.
Abstract BACKGROUND: The activity staging of Crohn's disease (CD) in the terminal ileum is critical in developing an accurate clinical treatment plan. The activity of terminal ileum CD is associated with the microcirculation of involved bowel walls. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging (DWI) can reflect perfusion and permeability of bowel walls by providing microcirculation information. As such, we hypothesize that DCE-MRI and DWI parameters can assess terminal ileum CD, thereby providing an opportunity to stage CD activity. AIM: To evaluate the value o...
Source: World Journal of Gastroenterology : WJG - October 21, 2020 Category: Gastroenterology Authors: Wu YC, Xiao ZB, Lin XH, Zheng XY, Cao DR, Zhang ZS Tags: World J Gastroenterol Source Type: research

Relationship of meteorological factors and air pollutants with medical care utilization for gastroesophageal reflux disease in urban area.
CONCLUSION: Using five MFAPs, the final model significantly predicted GERD-related medical utilization. In particular, PM2.5 and CO were identified as risk or aggravating factors for GERD. PMID: 33132656 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2020 Category: Gastroenterology Authors: Seo HS, Hong J, Jung J Tags: World J Gastroenterol Source Type: research

Acute gastrointestinal injury in critically ill patients with COVID-19 in Wuhan, China.
Abstract BACKGROUND: The coronavirus disease 2019 (COVID-19) is spreading rapidly around the world. Most critically ill patients have organ injury, including acute respiratory distress syndrome, acute kidney injury, cardiac injury, or liver dysfunction. However, few studies on acute gastrointestinal injury (AGI) have been reported in critically ill patients with COVID-19. AIM: To investigate the prevalence and outcomes of AGI in critically ill patients with COVID-19. METHODS: In this retrospective study, demographic data, laboratory parameters, AGI grades, clinical severity and outcomes were collected. T...
Source: World Journal of Gastroenterology : WJG - October 21, 2020 Category: Gastroenterology Authors: Sun JK, Liu Y, Zou L, Zhang WH, Li JJ, Wang Y, Kan XH, Chen JD, Shi QK, Yuan ST Tags: World J Gastroenterol Source Type: research

Impact of cap-assisted colonoscopy during transendoscopic enteral tubing: A randomized controlled trial.
Abstract BACKGROUND: Colonic transendoscopic enteral tubing (TET) requires double cecal intubation, raising a common concern of how to save cecal intubation time and make the tube stable. We hypothesized that cap-assisted colonoscopy (CC) might reduce the second cecal intubation time and bring potential benefits during the TET procedure. AIM: To investigate if CC can decrease the second cecal intubation time compared with regular colonoscopy (RC). METHODS: This prospective multicenter, randomized controlled trial was performed at four centers. Subjects ≥ 7 years needing colonic TET were recruited from...
Source: World Journal of Gastroenterology : WJG - October 21, 2020 Category: Gastroenterology Authors: Wen Q, Liu KJ, Cui BT, Li P, Wu X, Zhong M, Wei L, Tu H, Yuan Y, Lin D, Hsu WH, Wu DC, Yin H, Zhang FM Tags: World J Gastroenterol Source Type: research

Role of betaine in liver disease-worth revisiting or has the die been cast?
Abstract Nonalcoholic steatohepatitis (NASH) is an important indication for liver transplantation in many Western countries due to the epidemic of obesity and insulin resistance. Unfortunately, no medication is approved for NASH and risk factor modification is often advised. Over the last decade, several clinical trials on NASH have been conducted with several ongoing and the future looks promising. Although betaine (trimethyl glycine) was evaluated for NASH, results were mixed in the clinical trials in large part due to the quality of the studies. It seems reasonable to re-evaluate betaine in clinical trials for ...
Source: World Journal of Gastroenterology : WJG - October 14, 2020 Category: Gastroenterology Authors: Mukherjee S Tags: World J Gastroenterol Source Type: research

Management of an endoscopy center during the outbreak of COVID-19: Experience from West China Hospital.
We describe our management of the environment, endoscope, patients, and medical staff, and our self-made masks. PMID: 33132632 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2020 Category: Gastroenterology Authors: Gao Y, Ye LS, Du J, Zhang QY, Hu B Tags: World J Gastroenterol Source Type: research

Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma.
Abstract Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis, cancer, and liver failure. Liver cancer is the third leading cause of cancer-associated mortality, of which hepatocellular carcinoma (HCC) represents 90% of all primary liver cancers. Solid tumors like HCC are complex and have heterogeneous tumor genomic profiles contributing to complexity in diagnosis and management. Chronic infection with hepatitis B virus (HBV), hepatitis delta virus (HDV), and hepatitis C virus (HCV) are the greatest etiological risk factors for HCC. Due to the significant ro...
Source: World Journal of Gastroenterology : WJG - October 14, 2020 Category: Gastroenterology Authors: D'souza S, Lau KC, Coffin CS, Patel TR Tags: World J Gastroenterol Source Type: research

Role of artificial intelligence in the diagnosis of oesophageal neoplasia: 2020 an endoscopic odyssey.
dry R Abstract The past decade has seen significant advances in endoscopic imaging and optical enhancements to aid early diagnosis. There is still a treatment gap due to the underdiagnosis of lesions of the oesophagus. Computer aided diagnosis may play an important role in the coming years in providing an adjunct to endoscopists in the early detection and diagnosis of early oesophageal cancers, therefore curative endoscopic therapy can be offered. Research in this area of artificial intelligence is expanding and the future looks promising. In this review article we will review current advances in artificial intell...
Source: World Journal of Gastroenterology : WJG - October 14, 2020 Category: Gastroenterology Authors: Hussein M, González-Bueno Puyal J, Mountney P, Lovat LB, Haidry R Tags: World J Gastroenterol Source Type: research

Gastrointestinal complications after kidney transplantation.
Abstract Gastrointestinal complications are common after renal transplantation, and they have a wide clinical spectrum, varying from diarrhoea to post-transplant inflammatory bowel disease (IBD). Chronic immunosuppression may increase the risk of post-transplant infection and medication-related injury and may also be responsible for IBD in kidney transplant re-cipients despite immunosuppression. Differentiating the various forms of post-transplant colitis is challenging, since most have similar clinical and histological features. Drug-related colitis are the most frequently encountered colitis after kidney transpl...
Source: World Journal of Gastroenterology : WJG - October 14, 2020 Category: Gastroenterology Authors: Gioco R, Corona D, Ekser B, Puzzo L, Inserra G, Pinto F, Schipa C, Privitera F, Veroux P, Veroux M Tags: World J Gastroenterol Source Type: research

Is vitamin D receptor a druggable target for non-alcoholic steatohepatitis?
Abstract Nonalcoholic steatohepatitis (NASH) is a progressed stage of non-alcoholic fatty liver disease, and available therapeutic strategies for NASH are limited. Vitamin D receptor (VDR) is proposed as a druggable target for NASH due to the discovery of vitamin D deficiency in NASH patients. To date, vitamin D supplementation has not consistently conferred expected therapeutic benefits, raising the question of whether VDR can serve as a proper drug target for NASH. It is known that VDR can interact with other ligands such as bile acids in addition to vitamin D, and its expression can be induced by fatty acids, a...
Source: World Journal of Gastroenterology : WJG - October 14, 2020 Category: Gastroenterology Authors: Cao Y, Shu XB, Yao Z, Ji G, Zhang L Tags: World J Gastroenterol Source Type: research

Acetyl-11-keto- β-boswellic acid inhibits proliferation and induces apoptosis of gastric cancer cells through the phosphatase and tensin homolog /Akt/ cyclooxygenase-2 signaling pathway.
CONCLUSION: AKBA inhibits the proliferation and migration and promotes the apoptosis of gastric cancer cells through the PTEN/Akt/COX-2 signaling pathway. PMID: 33132637 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2020 Category: Gastroenterology Authors: Sun MX, He XP, Huang PY, Qi Q, Sun WH, Liu GS, Hua J Tags: World J Gastroenterol Source Type: research