Log in to search using one of your social media accounts:

 

Role of PTPN2/22 polymorphisms in pathophysiology of Crohn's disease.
Abstract AIM: To establish the relationship of protein tyrosine phosphatase non-receptor type 2 and 22 (PTPN2/22) polymorphisms and mycobacterial infections in Crohn's disease (CD). METHODS: All 133 subjects' blood samples were genotyped for nine single nucleotide polymorphisms (SNPs) in PTPN2/22 using TaqMan™ genotyping, while the effect of the SNPs on PTPN2/22 and IFN-γ gene expression was determined using RT-PCR. Detection of Mycobacterium avium subspecies paratuberculosis (MAP) IS900 gene was done by nPCR after DNA extraction from the isolated leukocytes of each subjects' blood samples. T-cell...
Source: World Journal of Gastroenterology : WJG - February 14, 2018 Category: Gastroenterology Authors: Sharp RC, Beg SA, Naser SA Tags: World J Gastroenterol Source Type: research

Health-related quality of life, anxiety, depression and impulsivity in patients with advanced gastroenteropancreatic neuroendocrine tumours.
Abstract AIM: To compare health-related quality of life (HRQoL), anxiety, depression, and impulsivity scores in patients with and without carcinoid syndrome (CS), and correlated them with serum 5-hydroxyindoleacetic acid (5-HIAA) levels. METHODS: Patients with advanced gastroenteropancreatic neuroendocrine tumours (GEPNET), with and without CS completed HRQoL QLQ-C30 and QLQ-GI.NET21, Hospital Anxiety and Depression Scale (HADS) and Barratt Impulsivity Scale (BIS) questionnaires. Two-sample Wilcoxon test was applied to assess differences in serum 5-HIAA levels, two-sample Mann-Whitney U test for HRQoL and BIS...
Source: World Journal of Gastroenterology : WJG - February 14, 2018 Category: Gastroenterology Authors: Lewis AR, Wang X, Magdalani L, D'Arienzo P, Bashir C, Mansoor W, Hubner R, Valle JW, McNamara MG Tags: World J Gastroenterol Source Type: research

Analysis of hepatitis B virus preS1 variability and prevalence of the rs2296651 polymorphism in a Spanish population.
CONCLUSION: In our CHB population, the NTCP-interacting domain was highly conserved, particularly the proline residues and essential amino acids related with the NTCP interaction, and the prevalence of rs2296651 was low/null. PMID: 29456407 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2018 Category: Gastroenterology Authors: Casillas R, Tabernero D, Gregori J, Belmonte I, Cortese MF, González C, Riveiro-Barciela M, López RM, Quer J, Esteban R, Buti M, Rodríguez-Frías F Tags: World J Gastroenterol Source Type: research

Inhibitory effects of patchouli alcohol on stress-induced diarrhea-predominant irritable bowel syndrome.
Abstract AIM: To elucidate the mechanism of patchouli alcohol (PA) in treatment of rat models of diarrhea-predominant irritable bowel syndrome (IBS-D). METHODS: We studied the effects of PA on colonic spontaneous motility using its cumulative log concentration (3 × 10-7 mol/L to 1 × 10-4 mol/L). We then determined the responses of the proximal and distal colon segments of rats to the following stimuli: (1) carbachol (1 × 10-9 mol/L to 1 × 10-5 mol/L); (2) neurotransmitter antagonists including Nω-nitro-L-arginine methyl ester hydrochloride (10 μmol/L) and (1R*, 2S*)-4-[2-Iodo-...
Source: World Journal of Gastroenterology : WJG - February 14, 2018 Category: Gastroenterology Authors: Zhou TR, Huang JJ, Huang ZT, Cao HY, Tan B Tags: World J Gastroenterol Source Type: research

Recombinant expressed vasoactive intestinal peptide analogue ameliorates TNBS-induced colitis in rats.
Abstract AIM: To investigate the modulatory effect of recombinant-expressed vasoactive intestinal peptide (VIP) analogue (rVIPa) on trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. METHODS: Forty-eight rats were randomized into six groups: normal control group (Control), model control group (TNBS), ethanol treatment group (ETOH), and VIP treatment groups with different dosage (rVIPa1nmol, rVIPa2nmol, rVIPa4nmol). Diarrhea and bloody stool were observed. Colonic damage was evaluated histologically. The levels of tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), myeloperoxidase (...
Source: World Journal of Gastroenterology : WJG - February 14, 2018 Category: Gastroenterology Authors: Xu CL, Guo Y, Qiao L, Ma L, Cheng YY Tags: World J Gastroenterol Source Type: research

Split-dose bowel preparation improves adequacy of bowel preparation and gastroenterologists' adherence to National Colorectal Cancer Screening and Surveillance Guidelines.
Abstract AIM: To quantify the impact of split-dose regimen on endoscopists' compliance with guideline recommendations for timing of repeat colonoscopy in patients with normal colonoscopy or 1-2 small polyps ( 50 years old with a normal screening colonoscopy and 1-2 small polyps. Data were abstracted from two time periods, pre and post-split-dose bowel preparation institution. Main outcome measurements were recommendation for timing of repeat colonoscopy and bowel preparation quality. Bivariate analysis by χ2 tests and Student's t-tests were performed to assess differences between the two cohorts. Multivariable...
Source: World Journal of Gastroenterology : WJG - February 14, 2018 Category: Gastroenterology Authors: Menees SB, Kim HM, Schoenfeld P Tags: World J Gastroenterol Source Type: research

Clinical utility of hepatitis B surface antigen kinetics in treatment-na ïve chronic hepatitis B patients during long-term entecavir therapy.
CONCLUSION: Baseline HBsAg can be used to predict treatment responses. HBsAg levels and decrease rates should be considered together according to disease status while interpreting HBsAg changes. PMID: 29456411 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2018 Category: Gastroenterology Authors: Lin TC, Chiu YC, Chiu HC, Liu WC, Cheng PN, Chen CY, Chang TT, Wu IC Tags: World J Gastroenterol Source Type: research

Performance of transient elastography in assessing liver fibrosis in patients with autoimmune hepatitis-primary biliary cholangitis overlap syndrome.
Abstract AIM: To investigate the performance of transient elastography (TE) for diagnosis of fibrosis in patients with autoimmune hepatitis-primary biliary cholangitis (AIH-PBC) overlap syndrome. METHODS: A total of 70 patients with biopsy-proven AIH-PBC overlap syndrome were included. Spearman correlation test was used to analyze the correlation of liver stiffness measurement (LSM) and fibrosis stage. Independent samples Student's t-test or one-way analysis of variance was used to compare quantitative variables. Receiver operating characteristics (ROC) curve was used to calculate the optimal cut-off values o...
Source: World Journal of Gastroenterology : WJG - February 14, 2018 Category: Gastroenterology Authors: Wu HM, Sheng L, Wang Q, Bao H, Miao Q, Xiao X, Guo CJ, Li H, Ma X, Qiu DK, Hua J Tags: World J Gastroenterol Source Type: research

Value of contrast-enhanced ultrasound in the differential diagnosis of gallbladder lesion.
CONCLUSION: CEUS may provide more useful information and improve the diagnosis efficiency for the diagnosis of gallbladder lesions than conventional ultrasound. PMID: 29456413 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2018 Category: Gastroenterology Authors: Zhang HP, Bai M, Gu JY, He YQ, Qiao XH, Du LF Tags: World J Gastroenterol Source Type: research

High prevalence of hepatitis B-antibody loss and a case report of de novo hepatitis B virus infection in a child after living-donor liver transplantation.
This study focused on children with chronic liver diseases who received primary hepatitis B immunization and had a complete dataset of anti-HBs before and after liver transplantation between May 2001 and June 2017. Medical records were retrospectively reviewed for potential factors relating to HBV immunity loss. RESULTS: In total, 50 children were recruited. The mean time from liver transplantation to anti-HBs testing was 2.53 ± 2.11 years. The mean anti-HBs levels before and after liver transplantation were 584.41 ± 415.45 and 58.56 ± 6.40 IU/L, respectively. The rate of non-immunity (anti-HBs th...
Source: World Journal of Gastroenterology : WJG - February 14, 2018 Category: Gastroenterology Authors: Sintusek P, Posuwan N, Wanawongsawad P, Jitraruch S, Poovorawan Y, Chongsrisawat V Tags: World J Gastroenterol Source Type: research

Gastroenteritis in an adult female revealing hemolytic uremic syndrome: Case report.
z O, Méndez-Sánchez N Abstract Nowadays acute gastroenteritis infection caused by Escherichia coli (E. coli) O157:H7 is frequently associated with hemolytic uremic syndrome (HUS), which usually developed after prodromal diarrhea that is often bloody. The abdominal pain accompanied by failure kidney is a suspicious symptom to develop this disorder. Their pathological characteristic is vascular damage which manifested as arteriolar and capillary thrombosis with abnormalities in the endothelium and vessel walls. The major etiological agent of HUS is enterohemorragic (E coli) strain belonging to serotype...
Source: World Journal of Gastroenterology : WJG - February 14, 2018 Category: Gastroenterology Authors: Chinchilla-López P, Cruz-Ramón V, Ramírez-Pérez O, Méndez-Sánchez N Tags: World J Gastroenterol Source Type: research

Behind the curtain of non-coding RNAs; long non-coding RNAs regulating hepatocarcinogenesis.
Abstract Hepatocellular carcinoma (HCC) is one of the most common and aggressive cancers worldwide. HCC is the fifth common malignancy in the world and the second leading cause of cancer death in Asia. Long non-coding RNAs (lncRNAs) are RNAs with a length greater than 200 nucleotides that do not encode proteins. lncRNAs can regulate gene expression and protein synthesis in several ways by interacting with DNA, RNA and proteins in a sequence specific manner. They could regulate cellular and developmental processes through either gene inhibition or gene activation. Many studies have shown that dysregulation of lncRN...
Source: World Journal of Gastroenterology : WJG - February 7, 2018 Category: Gastroenterology Authors: El Khodiry A, Afify M, El Tayebi HM Tags: World J Gastroenterol Source Type: research

Hsa-miR-202-3p, up-regulated in type 1 gastric neuroendocrine neoplasms, may target DUSP1.
CONCLUSION: miR-202-3p is upregulated in type 1 g-NEN lesions and might play important roles in the pathogenesis of type 1 g-NENs by targeting DUSP1. PMID: 29434446 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2018 Category: Gastroenterology Authors: Dou D, Shi YF, Liu Q, Luo J, Liu JX, Liu M, Liu YY, Li YL, Qiu XD, Tan HY Tags: World J Gastroenterol Source Type: research

Enteral nutrition combined with glutamine promotes recovery after ileal pouch-anal anastomosis in rats.
Abstract AIM: To assess the effect of enteral nutrition (EN) supplemented with glutamine on recovery after ileal pouch-anal anastomosis (IPAA) in rats, to provide an experimental basis for nutritional support in patients with ulcerative colitis (UC) after IPAA. METHODS: Male Sprague-Dawley (SD) rats were randomly divided into three groups (n = 8) after IPAA operation using a microsurgical technique. From the third postoperative day, rats in the control group, EN group, and immune nutrition (IN) group were fed standard rat chow, short peptide EN, and short peptide EN combined with glutamine ad libitum, respect...
Source: World Journal of Gastroenterology : WJG - February 7, 2018 Category: Gastroenterology Authors: Xu YY, He AQ, Liu G, Li KY, Liu J, Liu T Tags: World J Gastroenterol Source Type: research

Promotion of Sema4D expression by tumor-associated macrophages: Significance in gastric carcinoma.
Abstract AIM: To study the role of semaphorin 4D (Sema4D) expression promoted by tumor-associated macrophages (TAMs) in gastric carcinoma cells and its clinical significance in the invasion and metastasis of gastric carcinoma. METHODS: CD68 and Sema4D expression was analyzed in gastric carcinoma and adjacent normal tissues from 290 patients using the immunohistochemical streptavidin-peroxidase method, and their relationships with clinicopathological features were evaluated. Human M2 macrophages were induced in vitro and co-cultured in non-contact with gastric carcinoma SGC-7901 cells. Changes in the secretory...
Source: World Journal of Gastroenterology : WJG - February 7, 2018 Category: Gastroenterology Authors: Li H, Wang JS, Mu LJ, Shan KS, Li LP, Zhou YB Tags: World J Gastroenterol Source Type: research

Impact of SNP-SNP interactions of DNA repair gene ERCC5 and metabolic gene GSTP1 on gastric cancer/atrophic gastritis risk in a Chinese population.
CONCLUSION: There is a multifarious interaction between the DNA repair gene ERCC5 SNPs (rs2094258 and rs873601) and the metabolic gene GSTP1 rs1695, which may form the basis for various inter-individual susceptibilities to AG. PMID: 29434449 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2018 Category: Gastroenterology Authors: Sang L, Lv Z, Sun LP, Xu Q, Yuan Y Tags: World J Gastroenterol Source Type: research

Incidence of hepatocellular carcinoma in patients with chronic liver disease due to hepatitis B or C and coinfected with the human immunodeficiency virus: A retrospective cohort study.
Abstract AIM: To assess the incidence of hepatocellular carcinoma (HCC) in chronic liver disease due to hepatitis B virus (HBV) or hepatitis C virus (HCV) coinfected with human immunodeficiency virus (HIV). METHODS: A retrospective cohort study was performed, including patients with chronic liver disease due to HBV or HCV, with and without HIV coinfection. Patients were selected in the largest tertiary public hospital complex in southern Brazil between January 2007 and June 2014. We assessed demographic and clinical data, including lifestyle habits such as illicit drug use or alcohol abuse, in addition to fre...
Source: World Journal of Gastroenterology : WJG - February 7, 2018 Category: Gastroenterology Authors: Marcon PDS, Tovo CV, Kliemann DA, Fisch P, de Mattos AA Tags: World J Gastroenterol Source Type: research

Impaired granulocyte-macrophage colony-stimulating factor bioactivity accelerates surgical recurrence in ileal Crohn's disease.
CONCLUSION: GM-CSF bioavailability plays a critical role in maintaining intestinal homeostasis. Decreased bioavailability coupled with the genetic risk markers and/or smoking results in aggressive CD behavior. PMID: 29434451 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2018 Category: Gastroenterology Authors: Gathungu G, Zhang Y, Tian X, Bonkowski E, Rowehl L, Krumsiek J, Nix B, Chalk C, Trapnell B, Zhu W, Newberry R, Denson L, Li E Tags: World J Gastroenterol Source Type: research

PIK3CA and TP53 mutations predict overall survival of stage II/III colorectal cancer patients.
CONCLUSION: Double mutation of PIK3CA and TP53 is correlated with a shorter OS in stage II/III CRC patients treated with 5-fluorouracil-based therapy. PMID: 29434452 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2018 Category: Gastroenterology Authors: Li AJ, Li HG, Tang EJ, Wu W, Chen Y, Jiang HH, Lin MB, Yin L Tags: World J Gastroenterol Source Type: research

Faecal calprotectin and magnetic resonance imaging in detecting Crohn's disease endoscopic postoperative recurrence.
CONCLUSION: Faecal calprotectin and MRI are two reliable tools to detect endoscopic POR in patients with CD. PMID: 29434453 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2018 Category: Gastroenterology Authors: Baillet P, Cadiot G, Goutte M, Goutorbe F, Brixi H, Hoeffel C, Allimant C, Reymond M, Obritin-Guilhen H, Magnin B, Bommelaer G, Pereira B, Hordonneau C, Buisson A Tags: World J Gastroenterol Source Type: research

Sequential spinal and intracranial dural metastases in gastric adenocarcinoma: A case report.
Abstract Dural metastasis from primary gastric adenocarcinoma has been rarely reported, and its prognosis is very poor because it frequently leads to acute subdural hematoma. Here, we describe a case with sequential spinal and cranial dural metastases from gastric adenocarcinoma without subdural hematoma. A 43-year-old woman with gastric adenocarcinoma and well-controlled peritoneal carcinomatosis presented with back pain, right radiating leg pain, left facial palsy, and hearing loss. Magnetic resonance imaging of the spine and brain revealed dural masses at the lumbosacral junction with invasion to the L5 and S1 ...
Source: World Journal of Gastroenterology : WJG - February 7, 2018 Category: Gastroenterology Authors: Kim H, Yi KS, Kim WD, Son SM, Yang Y, Kwon J, Han HS Tags: World J Gastroenterol Source Type: research

Vitamin D deficiency and hepatitis viruses-associated liver diseases: A literature review.
Abstract The secosteroid hormone vitamin D has, in addition to its effects in bone metabolism also functions in the modulation of immune responses against infectious agents and in inhibiting tumorigenesis. Thus, deficiency of vitamin D is associated with several malignancies, but also with a plethora of infectious diseases. Among other communicable diseases, vitamin D deficiency is involved in the pathogenesis of chronic liver diseases caused by hepatitis B and C viruses (HBV, HCV) and high prevalence of vitamin D deficiency with serum levels below 20 mg/mL in patients with HBV and HCV infection are found worldwid...
Source: World Journal of Gastroenterology : WJG - January 28, 2018 Category: Gastroenterology Authors: Hoan NX, Tong HV, Song LH, Meyer CG, Velavan TP Tags: World J Gastroenterol Source Type: research

Diet switch and omega-3 hydroxy-fatty acids display differential hepatoprotective effects in an obesity/nonalcoholic fatty liver disease model in mice.
CONCLUSION: 18-HEPE and 17-HDHA differentially exert hepatoprotective effects through up-regulation of nuclear receptors PPARα/γ and amelioration of serum adipokines profile. PMID: 29398867 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2018 Category: Gastroenterology Authors: Rodriguez-Echevarria R, Macias-Barragan J, Parra-Vargas M, Davila-Rodriguez JR, Amezcua-Galvez E, Armendariz-Borunda J Tags: World J Gastroenterol Source Type: research

Overexpression of CREPT confers colorectal cancer sensitivity to fluorouracil.
CONCLUSION: Aberrant overexpression of CREPT contributes to tumorigenesis of CRC by promoting cell proliferation and accelerating the cell cycle, and confers sensitivity to 5-FU. CREPT is a potential prognostic biomarker for 5-FU in CRC. PMID: 29398868 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2018 Category: Gastroenterology Authors: Kuang YS, Wang Y, Ding LD, Yang L, Wang Y, Liu SH, Zhu BT, Wang XN, Liu HY, Li J, Chang ZJ, Wang YY, Jia BQ Tags: World J Gastroenterol Source Type: research

Early prediction of survival in hepatocellular carcinoma patients treated with transarterial chemoembolization plus sorafenib.
CONCLUSION: The first follow-up 4-6 wk after TACE-S can be used as the earliest time point to assess the response to TACE-S, and patients with mRECIST-evaluated early disease control, no previous TACE, and no PVTT had better survival. PMID: 29398869 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2018 Category: Gastroenterology Authors: Meng XC, Chen BH, Huang JJ, Huang WS, Cai MY, Zhou JW, Guo YJ, Zhu KS Tags: World J Gastroenterol Source Type: research

Low glucose metabolism in hepatocellular carcinoma with GPC3 expression.
Abstract AIM: To investigate the relationship between glucose metabolism and glypican-3 (GPC3) expression in hepatocellular carcinoma (HCC). METHODS: Immunohistochemical staining of pathological samples for GPC3 and glucose transporter 1 (GLUT1), and whole-body 18F-FDG PET/CT for measuring tumour glucose uptake were performed in 55 newly diagnosed HCC patients. The maximum standard uptake value (SUVmax) and tumour-to-non-tumourous liver uptake (T/NT) ratio were used to quantify 18F-FDG uptake. In vitro18F-FDG uptake assay of GPC3-expressing HepG2 and non-GPC3-expressing RH7777 cells was used to examine the ef...
Source: World Journal of Gastroenterology : WJG - January 28, 2018 Category: Gastroenterology Authors: Li YC, Yang CS, Zhou WL, Li HS, Han YJ, Wang QS, Wu HB Tags: World J Gastroenterol Source Type: research

Application value of enhanced recovery after surgery for total laparoscopic uncut Roux-en-Y gastrojejunostomy after distal gastrectomy.
Abstract AIM: To evaluate the safety and feasibility of enhanced recovery after surgery (ERAS) for total laparoscopic uncut Roux-en-Y gastrojejunostomy after distal gastrectomy. METHODS: The clinical data of 42 patients who were divided into an ERAS group (n = 20) and a control group (n = 22) were collected. The observed indicators included operation conditions, postoperative clinical indexes, and postoperative serum stress indexes. Measurement data following a normal distribution are presented as mean ± SD and were analyzed by t-test. Count data were analyzed by χ2 test. RESULTS: The operativ...
Source: World Journal of Gastroenterology : WJG - January 28, 2018 Category: Gastroenterology Authors: Zang YF, Li FZ, Ji ZP, Ding YL Tags: World J Gastroenterol Source Type: research

Influence of NUDT15 variants on hematological pictures of patients with inflammatory bowel disease treated with thiopurines.
CONCLUSION: Mutations in exon 1 of NUDT15 also affect thiopurine-induced leukopenia in patients with IBD. To discuss thiopurine-induced leukopenia in more detail, investigation of SNPs in both exon 1 and exon 3 of NUDT15 is needed. PMID: 29398872 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2018 Category: Gastroenterology Authors: Kojima Y, Hirotsu Y, Omata W, Sugimori M, Takaoka S, Ashizawa H, Nakagomi K, Yoshimura D, Hosoda K, Suzuki Y, Mochizuki H, Omata M Tags: World J Gastroenterol Source Type: research

Impact of mechanical bowel preparation in elective colorectal surgery: A meta-analysis.
CONCLUSION: In the most comprehensive meta-analysis of mechanical bowel preparation in elective colorectal surgery to date, this study has suggested that the use of mechanical bowel preparation does not affect the incidence of postoperative complications when compared with no preparation. Hence, mechanical bowel preparation should not be administered routinely prior to elective colorectal surgery. PMID: 29398873 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2018 Category: Gastroenterology Authors: Rollins KE, Javanmard-Emamghissi H, Lobo DN Tags: World J Gastroenterol Source Type: research

Intraductal papillary bile duct adenocarcinoma and gastrointestinal stromal tumor in a case of neurofibromatosis type 1.
We report our experience with a synchronous case of gastrointestinal stromal tumor (GIST) and intraductal papillary neoplasm of the bile duct (IPNB) in an elderly woman with neurofibromatosis type 1 (NF-1). A 72-year-old woman presented with a 2-mo history of right upper abdominal pain unrelated to diet and indigestion. Fourteen years earlier, she had been diagnosed with NF-1, which manifested as café au lait spots and multiple nodules on the skin. Computed tomography (CT) revealed a multilocular low-density mass with septation, and mural nodules in the right hepatic lobe, as well as a 1.7-cm-sized well-demarcated e...
Source: World Journal of Gastroenterology : WJG - January 28, 2018 Category: Gastroenterology Authors: Lee JM, Lee JM, Hyun JJ, Choi HS, Kim ES, Keum B, Jeen YT, Chun HJ, Lee HS, Kim CD, Kim DS, Kim JY Tags: World J Gastroenterol Source Type: research

Neuroendocrine carcinoma of the gastric stump: A case report and literature review.
Abstract We herein report a case of neuroendocrine carcinoma of the gastric stump found 47 years after Billroth II gastric resection for a benign gastric ulcer. A 74-year-old man was referred to another hospital with melena. Endoscopic examination revealed a localized ulcerative lesion at the gastrojejunal anastomosis. The diagnosis by endoscopic biopsy was neuroendocrine carcinoma. A total gastrectomy of the remnant stomach with D2 lymphadenectomy was performed at our hospital. The lesion invaded the subserosa, and metastasis was found in two of nine the lymph nodes retrieved. The lesion was positive for synaptop...
Source: World Journal of Gastroenterology : WJG - January 28, 2018 Category: Gastroenterology Authors: Ma FH, Xue LY, Chen YT, Xie YB, Zhong YX, Xu Q, Tian YT Tags: World J Gastroenterol Source Type: research

Use of direct-acting antiviral agents in hepatitis C virus-infected liver transplant candidates.
Abstract Since the advent of direct acting antiviral (DAA) agents, chronic hepatitis C virus (HCV) treatment has evolved at a rapid pace. In contrast to prior regimen involving ribavirin and pegylated interferon, these newer agents are highly effective, well-tolerated, have shorter course of therapy and safer essentially in all HCV patients including those with advanced liver disease and following liver transplantation. Clinicians caring for HCV-infected patients on the liver transplant (LT) waitlist are often faced with a dilemma whether to treat HCV infection before or after liver transplantation. Sustained viro...
Source: World Journal of Gastroenterology : WJG - January 21, 2018 Category: Gastroenterology Authors: Gadiparthi C, Cholankeril G, Perumpail BJ, Yoo ER, Satapathy SK, Nair S, Ahmed A Tags: World J Gastroenterol Source Type: research

circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling.
CONCLUSION: Dysregulation of circRNA_0046366/miR-34a/PPARα signaling may be a novel epigenetic mechanism underlying hepatocellular steatosis. circRNA_0046366 serves as a potential target for the treatment of hepatic steatosis. PMID: 29391755 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 21, 2018 Category: Gastroenterology Authors: Guo XY, Sun F, Chen JN, Wang YQ, Pan Q, Fan JG Tags: World J Gastroenterol Source Type: research

Effect of Lactobacillus rhamnosus GG supernatant on serotonin transporter expression in rats with post-infectious irritable bowel syndrome.
CONCLUSION: LGG-s can up-regulate SERT mRNA and protein levels in intestinal tissue but has no influence in brain tissue in rats with PI-IBS. PMID: 29391756 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 21, 2018 Category: Gastroenterology Authors: Cao YN, Feng LJ, Liu YY, Jiang K, Zhang MJ, Gu YX, Wang BM, Gao J, Wang ZL, Wang YM Tags: World J Gastroenterol Source Type: research

Epidermal growth factor receptor-targeted immune magnetic liposomes capture circulating colorectal tumor cells efficiently.
CONCLUSION: EGFR antibody-coated magnetic liposomes show high efficiency and specificity in capturing colorectal CTCs. PMID: 29391757 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 21, 2018 Category: Gastroenterology Authors: Kuai JH, Wang Q, Zhang AJ, Zhang JY, Chen ZF, Wu KK, Hu XZ Tags: World J Gastroenterol Source Type: research

Hypoxia preconditioning protects Ca2+-ATPase activation of intestinal mucosal cells against R/I injury in a rat liver transplantation model.
CONCLUSION: Hypoxia-induced HIF-1α could protect intestinal mucosal cells against mitochondrial damage after I/R injury. HP could improve hypoxia tolerance in small intestinal mucosal cells and increase Ca2+-ATPase activity to reduce the apoptosis of and pathological damage to intestinal cells. HP could be a useful way to promote the earlier recovery of intestinal function after graft procedure. PMID: 29391758 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 21, 2018 Category: Gastroenterology Authors: Ji ZP, Li YX, Shi BX, Zhuang ZN, Yang JY, Guo S, Xu XZ, Xu KS, Li HL Tags: World J Gastroenterol Source Type: research

Multi-parameter gene expression profiling of peripheral blood for early detection of hepatocellular carcinoma.
CONCLUSION: Multi-parameter analysis methods may increase the diagnostic value compared to single factor analysis and they may be a trend of the clinical diagnosis in the future. PMID: 29391759 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 21, 2018 Category: Gastroenterology Authors: Xie H, Xue YQ, Liu P, Zhang PJ, Tian ST, Yang Z, Guo Z, Wang HM Tags: World J Gastroenterol Source Type: research

Clinical advantages of single port laparoscopic hepatectomy.
Abstract AIM: To evaluate the clinical advantages of single-port laparoscopic hepatectomy (SPLH) compare to multi-port laparoscopic hepatectomy (MPLH). METHODS: We retrospectively reviewed the medical records of 246 patients who underwent laparoscopic liver resection between January 2008 and December 2015 at our hospital. We divided the surgical technique into two groups; SPLH and MPLH. We performed laparoscopic liver resection for both benign and malignant disease. Major hepatectomy such as right and left hepatectomy was also done with sufficient disease-free margin. The operative time, the volume of blood l...
Source: World Journal of Gastroenterology : WJG - January 21, 2018 Category: Gastroenterology Authors: Han JH, You YK, Choi HJ, Hong TH, Kim DG Tags: World J Gastroenterol Source Type: research

Autoimmune liver disease-related autoantibodies in patients with biliary atresia.
Abstract AIM: To investigate the prevalence and clinical significance of autoimmune liver disease (ALD)-related autoantibodies in patients with biliary atresia (BA). METHODS: Sera of 124 BA patients and 140 age-matched non-BA controls were assayed for detection of the following autoantibodies: ALD profile and specific anti-nuclear antibodies (ANAs), by line-blot assay; ANA and anti-neutrophil cytoplasmic antibody (ANCA), by indirect immunofluorescence assay; specific ANCAs and anti-M2-3E, by enzyme linked immunosorbent assay. Associations of these autoantibodies with the clinical features of BA (i.e., cytomeg...
Source: World Journal of Gastroenterology : WJG - January 21, 2018 Category: Gastroenterology Authors: Pang SY, Dai YM, Zhang RZ, Chen YH, Peng XF, Fu J, Chen ZR, Liu YF, Yang LY, Wen Z, Yu JK, Liu HY Tags: World J Gastroenterol Source Type: research

Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin.
CONCLUSION: H. pylori infection and severity of gastric corpus pathology are associated with lower serum ghrelin. Further studies could confirm a lower ghrelin prevalence in cagA-positive patients. PMID: 29391762 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 21, 2018 Category: Gastroenterology Authors: Mantero P, Matus GS, Corti RE, Cabanne AM, Zerbetto de Palma GG, Marchesi Olid L, Piskorz MM, Zubillaga MB, Janjetic MA, Goldman CG Tags: World J Gastroenterol Source Type: research

Metal stents placement for refractory pancreatic duct stricture in children.
Abstract AIM: To evaluate the use of fully covered self-expandable metal stents (FCSEMSs) for pancreatic duct strictures in children with chronic pancreatitis. METHODS: Eight patients with refractory benign dominant stricture of the main pancreatic duct (MPD) were enrolled through chart reviews between December 2014 and June 2017 in a single center. Endoscopic retrograde cholangiopancreatography (ERCP) with placement of a 6-mm FCSEMS with dual flaps was performed. Endoscopic removal of FCSEMSs was performed with a snare or rat-tooth forceps. All procedures were performed by a pediatric gastroenterologist. For...
Source: World Journal of Gastroenterology : WJG - January 21, 2018 Category: Gastroenterology Authors: Jeong IS, Lee SH, Oh SH, Park DH, Kim KM Tags: World J Gastroenterol Source Type: research

Optimization of hepatobiliary phase delay time of Gd-EOB-DTPA-enhanced magnetic resonance imaging for identification of hepatocellular carcinoma in patients with cirrhosis of different degrees of severity.
Abstract AIM: To optimize the hepatobiliary phase delay time (HBP-DT) of Gd-EOB-DTPA-enhanced magnetic resonance imaging (GED-MRI) for more efficient identification of hepatocellular carcinoma (HCC) occurring in different degrees of cirrhosis assessed by Child-Pugh (CP) score. METHODS: The liver parenchyma signal intensity (LPSI), the liver parenchyma (LP)/HCC signal ratios, and the visibility of HCC at HBP-DT of 5, 10, 15, 20, and 25 min (i.e., DT-5, DT-10, DT-15, DT-20, and DT-25 ) after injection of Gd-EOB-DTPA were collected and analyzed in 73 patients with cirrhosis of different degrees of severity (incl...
Source: World Journal of Gastroenterology : WJG - January 21, 2018 Category: Gastroenterology Authors: Wu JW, Yu YC, Qu XL, Zhang Y, Gao H Tags: World J Gastroenterol Source Type: research

Epidemiology of inflammatory bowel disease in racial and ethnic migrant groups.
CONCLUSION: This review suggests that migration and race influence the risk of developing inflammatory bowel disease. This may be due to different inherent responses upon exposure to an environmental trigger in the adopted country. Further prospective studies on homogenous migrant populations are needed to validate these observations, with a parallel arm for in-depth investigation of putative drivers. PMID: 29391765 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 21, 2018 Category: Gastroenterology Authors: Misra R, Faiz O, Munkholm P, Burisch J, Arebi N Tags: World J Gastroenterol Source Type: research

Beneficial long term effect of a phosphodiesterase-5-inhibitor in cirrhotic portal hypertension: A case report with 8 years follow-up.
l W Abstract Non-selective beta-blockers are the mainstay of medical therapy for portal hypertension in liver cirrhosis. Inhibitors of phosphodiesterase-5 (PDE-5-inhibitors) reduce portal pressure in the acute setting by> 10% which may suggest a long-term beneficial effect. Currently, there is no available data on long-term treatment of portal hypertension with PDE-5-inhibitors. This case of a patient with liver cirrhosis secondary to autoimmune liver disease with episodes of bleeding from esophageal varices is the first documented case in which a treatment with a PDE-5-inhibitor for eight years was monitored. ...
Source: World Journal of Gastroenterology : WJG - January 21, 2018 Category: Gastroenterology Authors: Deibert P, Lazaro A, Stankovic Z, Schaffner D, Rössle M, Kreisel W Tags: World J Gastroenterol Source Type: research

Drug-eluting beads transarterial chemoembolization for hepatocellular carcinoma: Current state of the art.
Abstract Transarterial chemoembolization (TACE) represents the current gold standard for hepatocellular carcinoma (HCC) patients in intermediate stage. Conventional TACE (cTACE) is performed with the injection of an emulsion of a chemotherapeutic drug with lipiodol into the artery feeding the tumoral nodules, followed by embolization of the same vessel to obtain a synergistic effect of drug cytotoxic activity and ischemia. Aim of this review is to summarize the main characteristics of drug-eluting beads (DEB)-TACE and the clinical results reported so far in the literature. A literature search was conducted using P...
Source: World Journal of Gastroenterology : WJG - January 14, 2018 Category: Gastroenterology Authors: Facciorusso A Tags: World J Gastroenterol Source Type: research

Antifibrogenic effects of vitamin D derivatives on mouse pancreatic stellate cells.
r R Abstract AIM: To study the molecular effects of three different D-vitamins, vitamin D2, vitamin D3 and calcipotriol, in pancreatic stellate cells (PSCs). METHODS: Quiescent PSCs were isolated from mouse pancreas and activated in vitro by seeding on plastic surfaces. The cells were exposed to D-vitamins as primary cultures (early-activated PSCs) and upon re-culturing (fully-activated cells). Exhibition of vitamin A-containing lipid droplets was visualized by oil-red staining. Expression of α-smooth muscle actin (α-SMA), a marker of PSC activation, was monitored by immunofluorescence and immunob...
Source: World Journal of Gastroenterology : WJG - January 14, 2018 Category: Gastroenterology Authors: Wallbaum P, Rohde S, Ehlers L, Lange F, Hohn A, Bergner C, Schwarzenböck SM, Krause BJ, Jaster R Tags: World J Gastroenterol Source Type: research

Metabolic and hepatic effects of liraglutide, obeticholic acid and elafibranor in diet-induced obese mouse models of biopsy-confirmed nonalcoholic steatohepatitis.
CONCLUSION: DIO-NASH and ob/ob-NASH mouse models show distinct treatment effects of liraglutide, OCA, and elafibranor, being in general agreement with corresponding findings in clinical trials for NASH. The present data therefore further supports the clinical translatability and utility of DIO-NASH and ob/ob-NASH mouse models of NASH for probing the therapeutic efficacy of compounds in preclinical drug development for NASH. PMID: 29375204 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 14, 2018 Category: Gastroenterology Authors: Tølbøl KS, Kristiansen MN, Hansen HH, Veidal SS, Rigbolt KT, Gillum MP, Jelsing J, Vrang N, Feigh M Tags: World J Gastroenterol Source Type: research

INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis.
CONCLUSION: These findings confirm the potential utility of FXR and dual FXR/TGR5 activation as disease intervention strategies in NASH. PMID: 29375205 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 14, 2018 Category: Gastroenterology Authors: Roth JD, Feigh M, Veidal SS, Fensholdt LK, Rigbolt KT, Hansen HH, Chen LC, Petitjean M, Friley W, Vrang N, Jelsing J, Young M Tags: World J Gastroenterol Source Type: research

Novel concept of endoscopic device delivery station system for rapid and tight attachment of polyglycolic acid sheet.
CONCLUSION: DDSS was very useful for rapid delivering and tight attachment of PGAs, and has potentials of multi-purpose delivery station system. PMID: 29375206 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 14, 2018 Category: Gastroenterology Authors: Mori H, Kobara H, Nishiyama N, Masaki T Tags: World J Gastroenterol Source Type: research

β-arrestin 2 attenuates lipopolysaccharide-induced liver injury via inhibition of TLR4/NF-κB signaling pathway-mediated inflammation in mice.
CONCLUSION: β-arrestin 2 can protect liver tissue from LPS-induced injury via inhibition of TLR4/NF-κB signaling pathway-mediated inflammation. PMID: 29375207 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 14, 2018 Category: Gastroenterology Authors: Jiang MP, Xu C, Guo YW, Luo QJ, Li L, Liu HL, Jiang J, Chen HX, Wei XQ Tags: World J Gastroenterol Source Type: research