Inositol 1,4,5-trisphosphate receptor in the liver: Expression and function.
Abstract The liver is a complex organ that performs several functions to maintain homeostasis. These functions are modulated by calcium, a second messenger that regulates several intracellular events. In hepatocytes and cholangiocytes, which are the epithelial cell types in the liver, inositol 1,4,5-trisphosphate (InsP3) receptors (ITPR) are the only intracellular calcium release channels. Three isoforms of the ITPR have been described, named type 1, type 2 and type 3. These ITPR isoforms are differentially expressed in liver cells where they regulate distinct physiological functions. Changes in the expression lev...
Source: World Journal of Gastroenterology : WJG - November 28, 2019 Category: Gastroenterology Authors: Lemos FO, Florentino RM, Lima Filho ACM, Dos Santos ML, Leite MF Tags: World J Gastroenterol Source Type: research

Reduced microRNA 375 in colorectal cancer upregulates metadherin-mediated signaling.
CONCLUSION: Our findings suggest that suppressing MIR375 expression in CRC regulates cell proliferation and angiogenesis by increasing MTDH expression. Thus, MIR375 may be of therapeutic value in treating human CRC. PMID: 31802830 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 28, 2019 Category: Gastroenterology Authors: Han SH, Mo JS, Park WC, Chae SC Tags: World J Gastroenterol Source Type: research

Long noncoding RNA NALT1-induced gastric cancer invasion and metastasis via NOTCH signaling pathway.
CONCLUSION: NALT1 is overexpressed and promotes invasion and metastasis of GC. The mechanism may be related to regulation of NOTCH1 by NALT1 and its effect on NOTCH signaling pathway expression. PMID: 31802831 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 28, 2019 Category: Gastroenterology Authors: Piao HY, Guo S, Wang Y, Zhang J Tags: World J Gastroenterol Source Type: research

Gasdermin D-mediated hepatocyte pyroptosis expands inflammatory responses that aggravate acute liver failure by upregulating monocyte chemotactic protein 1/CC chemokine receptor-2 to recruit macrophages.
Abstract BACKGROUND: Massive hepatocyte death is the core event in acute liver failure (ALF). Gasdermin D (GSDMD)-mediated pyroptosis is a type of highly inflammatory cell death. However, the role of hepatocyte pyroptosis and its mechanisms of expanding inflammatory responses in ALF are unclear. AIM: To investigate the role and mechanisms of GSDMD-mediated hepatocyte pyroptosis through in vitro and in vivo experiments. METHODS: The expression of pyroptosis pathway-associated proteins in liver tissues from ALF patients and a hepatocyte injury model was examined by Western blot. GSDMD short hairpin RNA (sh...
Source: World Journal of Gastroenterology : WJG - November 28, 2019 Category: Gastroenterology Authors: Li H, Zhao XK, Cheng YJ, Zhang Q, Wu J, Lu S, Zhang W, Liu Y, Zhou MY, Wang Y, Yang J, Cheng ML Tags: World J Gastroenterol Source Type: research

Cystic duct cancer: Should it be deemed as a type of gallbladder cancer?
CONCLUSION: Our study suggested that CC should be categorized as a type of EC, not GC. Aggressive surgical attitude might be considered in CC cases, to see whether long-term prognosis could be immensely improved like the situation in EC. PMID: 31802833 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 28, 2019 Category: Gastroenterology Authors: Yu TN, Mao YY, Wei FQ, Liu H Tags: World J Gastroenterol Source Type: research

Real life efficacy and safety of direct-acting antiviral therapy for treatment of patients infected with hepatitis C virus genotypes 1, 2 and 3 in northwest China.
This study included 366 patients infected with HCV genotypes 1, 2 and 3, with or without cirrhosis, who were observed between May 2015 and December 2018. They were treated with ledipasvir and sofosbuvir (SOF) (genotype 1) with or without ribavirin (RBV), SOF and RBV (genotype 2), or SOF and daclatasvir (genotype 3), with or without RBV, for 12 or more wk. The participants' sustained virological responses (SVR) at post-treatment week 12 (SVR12) was the primary endpoint. The occurrence of adverse events and drug-drug interactions were recorded. RESULTS: In the 366 patients, genotype 1 (59.0%) was the most common genotyp...
Source: World Journal of Gastroenterology : WJG - November 28, 2019 Category: Gastroenterology Authors: Yang Y, Wu FP, Wang WJ, Shi JJ, Li YP, Zhang X, Dang SS Tags: World J Gastroenterol Source Type: research

Chronic pancreatitis and the heart disease: Still terra incognita?
CONCLUSION: Current evidence implicates a possible association between PEI and malnutrition in patients with CHF. Chronic pancreatic tissue hypoxic injury driven by prolonged splanchnic hypoperfusion is likely to contribute to malnutrition and cachexia in patients with CHF. On the other hand, CP and PEI seem to be an independent risk factor associated with an increased risk of cardiovascular events. PMID: 31802835 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 28, 2019 Category: Gastroenterology Authors: Nikolic S, Dugic A, Steiner C, Tsolakis AV, Haugen Löfman IM, Löhr JM, Vujasinovic M Tags: World J Gastroenterol Source Type: research

Primary gastric melanoma: A case report with imaging findings and 5-year follow-up.
CONCLUSION: Certain imaging characteristics could be revealed in PGM. Imaging examination can be of great value in preoperative diagnosis, differential diagnosis, and follow-up of patients with PGM. PMID: 31802836 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 28, 2019 Category: Gastroenterology Authors: Wang J, Yang F, Ao WQ, Liu C, Zhang WM, Xu FY Tags: World J Gastroenterol Source Type: research

Current status of associating liver partition with portal vein ligation for staged hepatectomy: Comparison with two-stage hepatectomy and strategies for better outcomes.
Abstract Since its introduction in 2012, associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) has significantly expanded the pool of candidates for liver resection. It offers patients with insufficient liver function a chance of a cure. ALPPS is most controversial when its high morbidity and mortality is concerned. Operative mortality is usually a result of post-hepatectomy liver failure and can be minimized with careful patient selection. Elderly patients have limited reserve for tolerating the demanding operation. Patients with colorectal liver metastasis have normal liver and are...
Source: World Journal of Gastroenterology : WJG - November 21, 2019 Category: Gastroenterology Authors: Au KP, Chan ACY Tags: World J Gastroenterol Source Type: research

Ubiquitin-conjugating enzyme E2T knockdown suppresses hepatocellular tumorigenesis via inducing cell cycle arrest and apoptosis.
CONCLUSION: UBE2T plays an important role in cell cycle progression, apoptosis, and HCC development. PMID: 31798276 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 21, 2019 Category: Gastroenterology Authors: Guo J, Wang M, Wang JP, Wu CX Tags: World J Gastroenterol Source Type: research

Mitochondrial metabolomic profiling for elucidating the alleviating potential of Polygonatum kingianum against high-fat diet-induced nonalcoholic fatty liver disease.
CONCLUSION: PK can alleviate HFD-induced NAFLD by regulating the riboflavin metabolism and further improving the mitochondrial functions. Thus, PK is a promising mitochondrial regulator/nutrient for alleviating NAFLD-associated diseases. PMID: 31798277 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 21, 2019 Category: Gastroenterology Authors: Yang XX, Wei JD, Mu JK, Liu X, Li FJ, Li YQ, Gu W, Li JP, Yu J Tags: World J Gastroenterol Source Type: research

Altered profiles of fecal metabolites correlate with visceral hypersensitivity and may contribute to symptom severity of diarrhea-predominant irritable bowel syndrome.
Abstract BACKGROUND: Fecal metabolites are associated with gut visceral sensitivity, mucosal immune function and intestinal barrier function, all of which have critical roles in the pathogenesis of irritable bowel syndrome (IBS). However, the metabolic profile and pathophysiology of IBS are still unclear. We hypothesized that altered profiles of fecal metabolites might be involved in the pathogenesis of IBS with predominant diarrhea (IBS-D). AIM: To investigate the fecal metabolite composition and the role of metabolites in IBS-D pathophysiology. METHODS: Thirty IBS-D patients and 15 age- and sex-matched...
Source: World Journal of Gastroenterology : WJG - November 21, 2019 Category: Gastroenterology Authors: Zhang WX, Zhang Y, Qin G, Li KM, Wei W, Li SY, Yao SK Tags: World J Gastroenterol Source Type: research

Segmental intrahepatic cholestasis as a technical complication of the transjugular intrahepatic porto-systemic shunt.
CONCLUSION: SIC-T ads to (mostly late) complications in the interventional treatment of cirrhotic portal hypertensions and can lead to cholangitic abscesses. Patients, particularly with multiple interventions, should be screened for SIC-T. PMID: 31798279 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 21, 2019 Category: Gastroenterology Authors: Bucher JN, Hollenbach M, Strocka S, Gaebelein G, Moche M, Kaiser T, Bartels M, Hoffmeister A Tags: World J Gastroenterol Source Type: research

Serum amyloid A levels in patients with liver diseases.
Abstract BACKGROUND: Serum amyloid A (SAA) is an acute phase protein mainly synthesized by the liver. SAA induces inflammatory phenotype and promotes cell proliferation in activated hepatic stellate cells, the major scar forming cells in the liver. However, few studies have reported on the serum levels of SAA in human liver disease and its clinical significance in various liver diseases. AIM: To investigate the serum levels of SAA in patients with different liver diseases and analyze the factors associated with the alteration of SAA levels in chronic hepatitis B (CHB) patients. METHODS: Two hundred and s...
Source: World Journal of Gastroenterology : WJG - November 21, 2019 Category: Gastroenterology Authors: Yuan ZY, Zhang XX, Wu YJ, Zeng ZP, She WM, Chen SY, Zhang YQ, Guo JS Tags: World J Gastroenterol Source Type: research

Application of preoperative artificial neural network based on blood biomarkers and clinicopathological parameters for predicting long-term survival of patients with gastric cancer.
Abstract BACKGROUND: Because of the powerful abilities of self-learning and handling complex biological information, artificial neural network (ANN) models have been widely applied to disease diagnosis, imaging analysis, and prognosis prediction. However, there has been no trained preoperative ANN (preope-ANN) model to preoperatively predict the prognosis of patients with gastric cancer (GC). AIM: To establish a neural network model that can predict long-term survival of GC patients before surgery to evaluate the tumor condition before the operation. METHODS: The clinicopathological data of 1608 GC patie...
Source: World Journal of Gastroenterology : WJG - November 21, 2019 Category: Gastroenterology Authors: Que SJ, Chen QY, Qing-Zhong, Liu ZY, Wang JB, Lin JX, Lu J, Cao LL, Lin M, Tu RH, Huang ZN, Lin JL, Zheng HL, Li P, Zheng CH, Huang CM, Xie JW Tags: World J Gastroenterol Source Type: research

Metabolic syndrome attenuates ulcerative colitis: Correlation with interleukin-10 and galectin-3 expression.
CONCLUSION: Local dominance of Gal-3 and IL-10 over pro-inflammatory mediators in patients with MetS may present a mechanism for limiting the inflammatory process and subsequent tissue damage in UC. PMID: 31798282 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 21, 2019 Category: Gastroenterology Authors: Jovanovic M, Simovic Markovic B, Gajovic N, Jurisevic M, Djukic A, Jovanovic I, Arsenijevic N, Lukic A, Zdravkovic N Tags: World J Gastroenterol Source Type: research

Helicobacter pylori in ancient human remains.
k A Abstract The bacterium Helicobacter pylori (H. pylori) infects the stomachs of approximately 50% of all humans. With its universal occurrence, high infectivity and virulence properties it is considered as one of the most severe global burdens of modern humankind. It has accompanied humans for many thousands of years, and due to its high genetic variability and vertical transmission, its population genetics reflects the history of human migrations. However, especially complex demographic events such as the colonisation of Europe cannot be resolved with population genetic analysis of modern H. pylori strains alo...
Source: World Journal of Gastroenterology : WJG - November 14, 2019 Category: Gastroenterology Authors: Maixner F, Thorell K, Granehäll L, Linz B, Moodley Y, Rattei T, Engstrand L, Zink A Tags: World J Gastroenterol Source Type: research

Knockdown of lncRNAXLOC_001659 inhibits proliferation and invasion of esophageal squamous cell carcinoma cells.
CONCLUSION: Knockdown of lncRNA XLOC_001659 inhibits proliferation and invasion of ESCC cells via regulation of miR-490-5p/PIK3CA, suggesting that it may play a role in ESCC tumorigenesis and progression. PMID: 31754291 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2019 Category: Gastroenterology Authors: Li FZ, Zang WQ Tags: World J Gastroenterol Source Type: research

MicroRNA-30c inhibits pancreatic cancer cell proliferation by targeting twinfilin 1 and indicates a poor prognosis.
CONCLUSION: Our results identified the role of the miR-30c/TWF1 axis in pancreatic cancer progression and demonstrated that miR-30c might serve as a prognostic biomarker and therapeutic target for pancreatic cancer. PMID: 31754292 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2019 Category: Gastroenterology Authors: Sun LL, Cheng M, Xu XD Tags: World J Gastroenterol Source Type: research

MicroRNA signature in patients with hepatocellular carcinoma associated with type 2 diabetes.
CONCLUSION: This study validates a panel of serum miRNAs that can be used as a reliable noninvasive screening biomarker of HCC among T2DM cirrhotic and noncirrhotic patients. The study recommends further research to shed light on a possible role of c-Met in T2DM-associated HCC via the miRNA regulatory pathway. PMID: 31754293 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2019 Category: Gastroenterology Authors: Elemeery MN, Mohamed MA, Madkour MA, Shamseya MM, Issa NM, Badr AN, Ghareeb DA, Pan CH Tags: World J Gastroenterol Source Type: research

Changes of gastric ulcer bleeding in the metropolitan area of Japan.
Abstract BACKGROUND: The two main causes of gastric ulcer bleeding are Helicobacter pylori (H. pylori) infection and ulcerogenic medicines, although the number of cases caused by each may vary with age. In Japan, the rate of H. pylori infection has fallen over the last decade and the number of prescriptions for non-steroidal anti-inflammatory drugs (NSAIDs) and antithrombotic drugs is increasing as the population ages. Methods of treatment for gastric ulcer bleeding have advanced with the advent of hemostatic forceps and potassium-competitive acid blocker (P-CAB). Thus, causes and treatments for gastric ulcer blee...
Source: World Journal of Gastroenterology : WJG - November 14, 2019 Category: Gastroenterology Authors: Kubosawa Y, Mori H, Kinoshita S, Nakazato Y, Fujimoto A, Kikuchi M, Nishizawa T, Suzuki M, Suzuki H Tags: World J Gastroenterol Source Type: research

Risk of inflammatory bowel disease in patients with chronic obstructive pulmonary disease: A nationwide, population-based study.
Abstract BACKGROUND: There is a growing evidence regarding an increased risk of inflammatory bowel disease (IBD) among patients with airway diseases. AIM: To investigate the influence of chronic obstructive pulmonary disease (COPD) on the risk of IBD. METHODS: A nationwide, population-based study was conducted using data from the National Health Insurance Service database. A total of 1303021 patients with COPD and 6515105 non-COPD controls were identified. The COPD group was divided into the severe and the mild COPD group according to diagnostic criteria. The risk of IBD in patients with COPD compared to...
Source: World Journal of Gastroenterology : WJG - November 14, 2019 Category: Gastroenterology Authors: Lee J, Im JP, Han K, Park S, Soh H, Choi K, Kim J, Chun J, Kim JS Tags: World J Gastroenterol Source Type: research

Epidemiologic characteristics of Helicobacter pylori infection in southeast Hungary.
CONCLUSION: Although the prevalence of H. pylori infection decreased in recent decades in Southeast Hungary, it remains high in middle-aged rural populations. Generally accepted risk factors for H. pylori positivity appeared to be valid for the studied population. PMID: 31754296 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2019 Category: Gastroenterology Authors: Bálint L, Tiszai A, Kozák G, Dóczi I, Szekeres V, Inczefi O, Ollé G, Helle K, Róka R, Rosztóczy A Tags: World J Gastroenterol Source Type: research

Therapeutic potential of menstrual blood stem cells in treating acute liver failure.
Abstract BACKGROUND: Acute liver failure (ALF) is a significant and complex hepatic insult that may rapidly progress to life-threatening conditions. Recently, menstrual blood stem cells (MenSCs) have been identified as a group of easily accessible mesenchymal stem cells with the advantages of non-invasive acquisition, low immunogenicity, a greater capacity of self-renewal and multi-lineage differentiation, making them promising candidates for stem cell-based therapy to revolutionize the treatment strategies for liver failure. AIM: To investigate the therapeutic potential of MenSCs for treating ALF in pigs and...
Source: World Journal of Gastroenterology : WJG - November 7, 2019 Category: Gastroenterology Authors: Cen PP, Fan LX, Wang J, Chen JJ, Li LJ Tags: World J Gastroenterol Source Type: research

Disease monitoring strategies in inflammatory bowel diseases: What do we mean by "tight control"?
Disease monitoring strategies in inflammatory bowel diseases: What do we mean by "tight control"? World J Gastroenterol. 2019 Nov 07;25(41):6172-6189 Authors: Gonczi L, Bessissow T, Lakatos PL Abstract In recent years, there has been a critical change in treatment paradigms in inflammatory bowel diseases (IBD) triggered by the arrival of new effective treatments aiming to prevent disease progression, bowel damage and disability. The insufficiency of symptomatic disease control and the well-known discordance between symptoms and objective measures of disease activity lead to the need of revie...
Source: World Journal of Gastroenterology : WJG - November 7, 2019 Category: Gastroenterology Authors: Gonczi L, Bessissow T, Lakatos PL Tags: World J Gastroenterol Source Type: research

Yinchenhao decoction attenuates obstructive jaundice-induced liver injury and hepatocyte apoptosis by suppressing protein kinase RNA-like endoplasmic reticulum kinase-induced pathway.
CONCLUSION: OJ-induced liver injury and hepatocyte apoptosis are associated with the activation of the PERK-CHOP-GADD34 pathway and increased Bax/Bcl-2 ratio. YCHD can attenuate these changes. PMID: 31749592 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 7, 2019 Category: Gastroenterology Authors: Wu YL, Li ZL, Zhang XB, Liu H Tags: World J Gastroenterol Source Type: research

MiR-32-5p aggravates intestinal epithelial cell injury in pediatric enteritis induced by Helicobacter pylori.
CONCLUSION: Our work uncovered the crucial role of aberrant expression of miR-32-5p in H. pylori-related pediatric enteritis, and suggested that the TAK1-p38 pathway is involved in it. PMID: 31749593 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 7, 2019 Category: Gastroenterology Authors: Feng J, Guo J, Wang JP, Chai BF Tags: World J Gastroenterol Source Type: research

Bacterobilia in pancreatic surgery-conclusions for perioperative antibiotic prophylaxis.
r H Abstract BACKGROUND: Jaundice or preoperative cholestasis (PC) are typical symptoms of pancreatic masses. Approximately 50% of patients undergo preoperative biliary drainage (PBD) placement. PBD is a common cause of bacterobilia (BB) and is a known surgical site infection risk factor. An adjustment of preoperative antibiotic prophylaxis (PAP) may be reasonable according to the profile of BB. For this, we examined the microbiological findings in routine series of patients. AIM: To investigate the incidence and profile of biliary bacterial colonization in patients undergoing pancreatic head resections. ...
Source: World Journal of Gastroenterology : WJG - November 7, 2019 Category: Gastroenterology Authors: Krüger CM, Adam U, Adam T, Kramer A, Heidecke CD, Makowiec F, Riediger H Tags: World J Gastroenterol Source Type: research

Tumor-infiltrating platelets predict postoperative recurrence and survival in resectable pancreatic neuroendocrine tumor.
CONCLUSION: TIPs are a useful prognostic biomarker for patients with resectable pNET, and their detection represents a promising tool for pNET treatment strategy decisions. PMID: 31749595 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 7, 2019 Category: Gastroenterology Authors: Xu SS, Xu HX, Wang WQ, Li S, Li H, Li TJ, Zhang WH, Liu L, Yu XJ Tags: World J Gastroenterol Source Type: research

Blood parameters score predicts long-term outcomes in stage II-III gastric cancer patients.
CONCLUSION: The BPM score provides more accurate prognosis prediction in stage II-III GC patients and is an effective complement to the TNM staging system. PMID: 31749596 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 7, 2019 Category: Gastroenterology Authors: Lin JX, Tang YH, Wang JB, Lu J, Chen QY, Cao LL, Lin M, Tu RH, Huang CM, Li P, Zheng CH, Xie JW Tags: World J Gastroenterol Source Type: research

Increased circulating circular RNA_103516 is a novel biomarker for inflammatory bowel disease in adult patients.
Abstract BACKGROUND: Increasing evidence demonstrates that by acting as microRNA sponges modulating gene expression at the transcriptional or post-transcriptional level, circular RNAs (circRNAs) participate in the pathogenesis of a variety of diseases and are considered ideal biomarkers of human disease. AIM: To examine the expression of circRNA_103516 in inflammatory bowel disease (IBD) and its associations with clinical phenotypes and inflammatory cytokines. METHODS: Peripheral blood mononuclear cells (PBMCs) were obtained from patients with IBD, healthy controls (HCs), and patient controls (PCs). Expr...
Source: World Journal of Gastroenterology : WJG - November 7, 2019 Category: Gastroenterology Authors: Ye YL, Yin J, Hu T, Zhang LP, Wu LY, Pang Z Tags: World J Gastroenterol Source Type: research

Role of liver biopsy in hepatocellular carcinoma.
Abstract The role of liver biopsy in the diagnosis of hepatocellular carcinoma (HCC) has been challenged over time by the ability of imaging techniques to characterize liver lesions in patients with known cirrhosis. In fact, in the diagnostic algorithm for this tumor, histology is currently relegated to controversial cases. Furthermore, the risk of complications, such as tumor seeding and bleeding, as well as inadequate sampling have further limited the use of liver biopsy for HCC management. However, there is growing evidence of prognostic and therapeutic information available from microscopic and molecular analy...
Source: World Journal of Gastroenterology : WJG - October 28, 2019 Category: Gastroenterology Authors: Di Tommaso L, Spadaccini M, Donadon M, Personeni N, Elamin A, Aghemo A, Lleo A Tags: World J Gastroenterol Source Type: research

Ultrasound-based techniques for the diagnosis of liver steatosis.
Abstract Non-alcoholic fatty liver disease (NAFLD) is the leading cause of diffuse liver disease. An accurate estimate of the fat in the liver is important in the diagnostic work-up of patients with NAFLD because the degree of liver steatosis is linked to the metabolic syndrome and the cardiovascular risk. Ultrasound (US) B-mode imaging allows to subjectively estimate the fatty infiltration in the liver; however, it has a low performance for the detection of mild steatosis. Quantitative US is based on the analysis of the radiofrequency echoes detected by an US system, and it allows to calculate a backscatter coeff...
Source: World Journal of Gastroenterology : WJG - October 28, 2019 Category: Gastroenterology Authors: Ferraioli G, Soares Monteiro LB Tags: World J Gastroenterol Source Type: research

Insulin-like growth factor 2 mRNA-binding protein 1 promotes cell proliferation via activation of AKT and is directly targeted by microRNA-494 in pancreatic cancer.
CONCLUSION: Our results revealed that upregulated IGF2BP1 promotes the proliferation of pancreatic cancer cells via the AKT signaling pathway and confirmed that the activation of IGF2BP1 is partly due to the silencing of miR-494. PMID: 31686763 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 28, 2019 Category: Gastroenterology Authors: Wan BS, Cheng M, Zhang L Tags: World J Gastroenterol Source Type: research

Nucleus tractus solitarius mediates hyperalgesia induced by chronic pancreatitis in rats.
Abstract BACKGROUND: Central sensitization plays a pivotal role in the maintenance of chronic pain induced by chronic pancreatitis (CP). We hypothesized that the nucleus tractus solitarius (NTS), a primary central site that integrates pancreatic afferents apart from the thoracic spinal dorsal horn, plays a key role in the pathogenesis of visceral hypersensitivity in a rat model of CP. AIM: To investigate the role of the NTS in the visceral hypersensitivity induced by chronic pancreatitis. METHODS: CP was induced by the intraductal injection of trinitrobenzene sulfonic acid (TNBS) in rats. Pancreatic hype...
Source: World Journal of Gastroenterology : WJG - October 28, 2019 Category: Gastroenterology Authors: Bai Y, Chen YB, Qiu XT, Chen YB, Ma LT, Li YQ, Sun HK, Zhang MM, Zhang T, Chen T, Fan BY, Li H, Li YQ Tags: World J Gastroenterol Source Type: research

Sustained virologic response to direct-acting antiviral agents predicts better outcomes in hepatitis C virus-infected patients: A retrospective study.
Abstract BACKGROUND: Direct-acting antiviral agents (DAAs) are extremely effective in eradicating hepatitis C virus (HCV) in chronically infected patients. However, the protective role of the sustained virologic response (SVR) achieved by second- and third-generation DAAs against the onset of hepatocellular carcinoma (HCC) and mortality is less well established. AIM: To examine the occurrence of HCC or death from any cause in a retrospective-prospective study of patients treated with DAAs. METHODS: Patients were enrolled from a tertiary academic hospital center for liver disease management that collects ...
Source: World Journal of Gastroenterology : WJG - October 28, 2019 Category: Gastroenterology Authors: Colussi G, Donnini D, Brizzi RF, Maier S, Valenti L, Catena C, Cavarape A, Sechi LA, Soardo G Tags: World J Gastroenterol Source Type: research

Endoscopic retrograde cholangiopancreatography in children with symptomatic pancreaticobiliary maljunction: A retrospective multicenter study.
CONCLUSION: ERCP is a safe and effective treatment option to relieve biliary or pancreatic obstruction in symptomatic PBM, with the characteristics of minor trauma, fewer complications, and repeatability. PMID: 31686766 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 28, 2019 Category: Gastroenterology Authors: Zeng JQ, Deng ZH, Yang KH, Zhang TA, Wang WY, Ji JM, Hu YB, Xu CD, Gong B Tags: World J Gastroenterol Source Type: research

Apparent diffusion coefficient-based histogram analysis differentiates histological subtypes of periampullary adenocarcinoma.
Abstract BACKGROUND: For periampullary adenocarcinoma, the histological subtype is a better prognostic predictor than the site of tumor origin. Intestinal-type periampullary adenocarcinoma (IPAC) is reported to have a better prognosis than the pan-creatobiliary-type periampullary adenocarcinoma (PPAC). However, the classification of histological subtypes is difficult to determine before surgery. Apparent diffusion coefficient (ADC) histogram analysis is a noninvasive, non-enhanced method with high reproducibility that could help differentiate the two subtypes. AIM: To investigate whether volumetric ADC histog...
Source: World Journal of Gastroenterology : WJG - October 28, 2019 Category: Gastroenterology Authors: Lu JY, Yu H, Zou XL, Li Z, Hu XM, Shen YQ, Hu DY Tags: World J Gastroenterol Source Type: research

Prebiotic UG1601 mitigates constipation-related events in association with gut microbiota: A randomized placebo-controlled intervention study.
Abstract BACKGROUND: Constipation is a common functional gastrointestinal disorder and its etiology is multifactorial. Growing evidence suggests that intestinal dysbiosis is associated with the development of constipation. Prebiotics are subjected to bacterial fermentation in the gut to produce short-chain fatty acids (SCFAs), which can help relieve constipation symptoms. The prebiotic UG1601 consists of inulin, lactitol, and aloe vera gel, which are known laxatives, but randomized, controlled clinical trials that examine the effects of this supplement on gut microbiota composition are lacking. AIM: To assess...
Source: World Journal of Gastroenterology : WJG - October 28, 2019 Category: Gastroenterology Authors: Chu JR, Kang SY, Kim SE, Lee SJ, Lee YC, Sung MK Tags: World J Gastroenterol Source Type: research

Ethnic differences in inflammatory bowel disease: Results from the United Kingdom inception cohort epidemiology study.
Abstract BACKGROUND: The current epidemiology of inflammatory bowel disease (IBD) in the multi-ethnic United Kingdom is unknown. The last incidence study in the United Kingdom was carried out over 20 years ago. AIM: To describe the incidence and phenotype of IBD and distribution within ethnic groups. METHODS: Adult patients (> 16 years) with newly diagnosed IBD (fulfilling Copenhagen diagnostic criteria) were prospectively recruited over one year in 5 urban catchment areas with high South Asian population. Patient demographics, ethnic codes, disease phenotype (Montreal classification), disease activit...
Source: World Journal of Gastroenterology : WJG - October 28, 2019 Category: Gastroenterology Authors: Misra R, Limdi J, Cooney R, Sakuma S, Brookes M, Fogden E, Pattni S, Sharma N, Iqbal T, Munkholm P, Burisch J, Arebi N Tags: World J Gastroenterol Source Type: research

Individualized home-monitoring of disease activity in adult patients with inflammatory bowel disease can be recommended in clinical practice: A randomized-clinical trial.
CONCLUSION: The two eHealth screening procedures are equally good in capturing a relapse and bringing about remission. However, the OD group used fewer FC home test-kits per patient. Individualized screening procedures can be recommended for adult IBD patients in clinical web-practice. PMID: 31686770 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 28, 2019 Category: Gastroenterology Authors: Ankersen DV, Weimers P, Marker D, Bennedsen M, Saboori S, Paridaens K, Burisch J, Munkholm P Tags: World J Gastroenterol Source Type: research

Gut-liver axis signaling in portal hypertension.
Abstract Portal hypertension (PHT) in advanced chronic liver disease (ACLD) results from increased intrahepatic resistance caused by pathologic changes of liver tissue composition (structural component) and intrahepatic vasoconstriction (functional component). PHT is an important driver of hepatic decompensation such as development of ascites or variceal bleeding. Dysbiosis and an impaired intestinal barrier in ACLD facilitate translocation of bacteria and pathogen-associated molecular patterns (PAMPs) that promote disease progression via immune system activation with subsequent induction of proinflammatory and pr...
Source: World Journal of Gastroenterology : WJG - October 21, 2019 Category: Gastroenterology Authors: Simbrunner B, Mandorfer M, Trauner M, Reiberger T Tags: World J Gastroenterol Source Type: research

Role of tristetraprolin phosphorylation in paediatric patients with inflammatory bowel disease.
CONCLUSION: In this work, for the first time, we describe a relation between phospho-TTP/14-3-3 complex and IBD. Indeed, a higher expression of TTP/14-3-3 was recorded in IBD samples in comparison to controls. PMID: 31660029 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2019 Category: Gastroenterology Authors: Di Silvestre A, Lucafò M, Pugnetti L, Bramuzzo M, Stocco G, Barbi E, Decorti G Tags: World J Gastroenterol Source Type: research

STW 5 is effective against nonsteroidal anti-inflammatory drugs induced gastro-duodenal lesions in rats.
CONCLUSION: The findings support the therapeutic usefulness of STW 5 and its superiority over omeprazole as adjuvant therapy to NSAIDs to protect against their possible gastro-duodenal side effects. PMID: 31660030 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2019 Category: Gastroenterology Authors: Khayyal MT, Wadie W, Abd El-Haleim EA, Ahmed KA, Kelber O, Ammar RM, Abdel-Aziz H Tags: World J Gastroenterol Source Type: research

Superior gallstone dissolubility and safety of tert-amyl ethyl ether over methyl-tertiary butyl ether.
CONCLUSION: We demonstrated that TAEE has higher gallstone dissolubility properties and safety than those of MTBE. As such, TAEE could present an attractive alternative to MTBE if our findings regarding its efficacy and safety can be consistently reproduced in further subclinical and clinical studies. PMID: 31660031 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2019 Category: Gastroenterology Authors: You DD, Cho SJ, Kim OH, Song JS, Hwang KS, Lee SC, Kim KH, Choi HJ, Hong HE, Seo H, Hong TH, Park JH, Lee TY, Ahn J, Jung JK, Jung KY, Kim SJ Tags: World J Gastroenterol Source Type: research

Gender differences in vascular reactivity of mesenteric arterioles in portal hypertensive and non-portal hypertensive rats.
Abstract BACKGROUND: Portal hypertension (PHT) is primarily caused by an increase in resistance to portal outflow and secondarily by an increase in splanchnic blood flow. Vascular hyporeactivity both in systemic circulation and in the mesenteric artery plays a role in the hyperdynamic circulatory syndrome. AIM: To explore gender differences and the role of endogenous sex hormones in PHT and vascular reactivity of mesenteric arterioles in rats. METHODS: Cirrhosis and PHT were established by subcutaneous injection of carbon tetrachloride (CCl4) in both male and female integral and castrated rats (ovariecto...
Source: World Journal of Gastroenterology : WJG - October 21, 2019 Category: Gastroenterology Authors: Zhang B, Ji LH, Zhang CG, Zhao G, Wu ZY Tags: World J Gastroenterol Source Type: research

Construction of a replication-competent hepatitis B virus vector carrying secreted luciferase transgene and establishment of new hepatitis B virus replication and expression cell lines.
CONCLUSION: Our research demonstrated that a replication-competent HBV vector carrying a secreted luciferase transgene possesses replication and expression ability, and the established HBV replication and expression cell lines could stably secrete viral particles carrying secNluc reporter gene. More importantly, the cell line and the secreted recombinant viral particles could be used to trace HBV replication or infection. PMID: 31660033 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2019 Category: Gastroenterology Authors: Ruan J, Ping CY, Sun S, Cheng X, Han PY, Zhang YG, Sun DX Tags: World J Gastroenterol Source Type: research

Differentially expressed long noncoding RNAs and regulatory mechanism of LINC02407 in human gastric adenocarcinoma.
CONCLUSION: LINC02407 plays a role in GC through the LINC02407-miR-6845-5p/miR-4455-ADGRD1 pathways, and thus, it may be an important oncogene and has potential value in GC diagnosis and treatment. PMID: 31660034 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2019 Category: Gastroenterology Authors: Zhou LL, Jiao Y, Chen HM, Kang LH, Yang Q, Li J, Guan M, Zhu G, Liu FQ, Wang S, Bai X, Song YQ Tags: World J Gastroenterol Source Type: research

Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres.
Abstract BACKGROUND: Mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN) is a rare diagnosis, mainly encountered in the gastro-entero-pancreatic tract. There is limited knowledge of its epidemiology, prognosis and biology, and the best management for affected patients is still to be defined. AIM: To investigate clinical-pathological characteristics, treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN. METHODS: Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres. Patient data were retrospecti...
Source: World Journal of Gastroenterology : WJG - October 21, 2019 Category: Gastroenterology Authors: Frizziero M, Wang X, Chakrabarty B, Childs A, Luong TV, Walter T, Khan MS, Morgan M, Christian A, Elshafie M, Shah T, Minicozzi A, Mansoor W, Meyer T, Lamarca A, Hubner RA, Valle JW, McNamara MG Tags: World J Gastroenterol Source Type: research

Recurrence and survival after surgery for pancreatic cancer with or without acute pancreatitis.
CONCLUSION: Patients with moderate or severe acute pancreatitis developed recurrences earlier than those without. Moderate or severe AP is associated with shorter overall and disease-free survival of patients with PDAC. PMID: 31660036 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2019 Category: Gastroenterology Authors: Feng Q, Li C, Zhang S, Tan CL, Mai G, Liu XB, Chen YH Tags: World J Gastroenterol Source Type: research