Extended lymphadenectomy in hilar cholangiocarcinoma: What it will bring?
Abstract Lymph node dissection is always a hot issue in radical resection of hilar cholangiocarcinoma (HCCA). There are still controversies regarding whether some lymph nodes should be dissected, of which the para-aortic lymph nodes are the most controversial. This review synthesized findings in the literature using the PubMed database of articles in the English language published between 1990 and 2019 on the effectiveness of extended lymphadenectomy including para-aortic lymph nodes dissection in radical resection of HCCA. Hepatobiliary surgeons have basically achieved a consensus that enough lymph nodes should b...
Source: World Journal of Gastroenterology : WJG - June 28, 2020 Category: Gastroenterology Authors: Li J, Zhou MH, Ma WJ, Li FY, Deng YL Tags: World J Gastroenterol Source Type: research

Non-invasive tests for the prediction of primary hepatocellular carcinoma.
Abstract Hepatocellular carcinoma (HCC) is one of the most common malignancies in the world and it is one of the main complications of cirrhosis and portal hypertension. Even in the presence of a well-established follow-up protocol for cirrhotic patients, to date poor data are available on predictive markers for primary HCC occurrence in the setting of compensated advanced chronic liver disease patients (cACLD). The gold standard method to evaluate the prognosis of patients with cACLD, beyond liver fibrosis assessed with histology, is the measurement of the hepatic venous pressure gradient (HVPG). An HVPG ≥10 m...
Source: World Journal of Gastroenterology : WJG - June 28, 2020 Category: Gastroenterology Authors: Marasco G, Colecchia A, Silva G, Rossini B, Eusebi LH, Ravaioli F, Dajti E, Alemanni LV, Colecchia L, Renzulli M, Golfieri R, Festi D Tags: World J Gastroenterol Source Type: research

Intestinal Ca2+ absorption revisited: A molecular and clinical approach.
ez ME Abstract Ca2+ has an important role in the maintenance of the skeleton and is involved in the main physiological processes. Its homeostasis is controlled by the intestine, kidney, bone and parathyroid glands. The intestinal Ca2+ absorption occurs mainly via the paracellular and the transcellular pathways. The proteins involved in both ways are regulated by calcitriol and other hormones as well as dietary factors. Fibroblast growth factor 23 (FGF-23) is a strong antagonist of vitamin D action. Part of the intestinal Ca2+ movement seems to be vitamin D independent. Intestinal Ca2+ absorption changes according ...
Source: World Journal of Gastroenterology : WJG - June 28, 2020 Category: Gastroenterology Authors: Areco VA, Kohan R, Talamoni G, Tolosa de Talamoni NG, Peralta López ME Tags: World J Gastroenterol Source Type: research

Interventions of natural and synthetic agents in inflammatory bowel disease, modulation of nitric oxide pathways.
Abstract Inflammatory bowel disease (IBD) refers to a group of disorders characterized by chronic inflammation of the gastrointestinal (GI) tract. The elevated levels of nitric oxide (NO) in serum and affected tissues; mainly synthesized by the inducible nitric oxide synthase (iNOS) enzyme; can exacerbate GI inflammation and is one of the major biomarkers of GI inflammation. Various natural and synthetic agents are able to ameliorate GI inflammation and decrease iNOS expression to the extent comparable with some IBD drugs. Thereby, the purpose of this study was to gather a list of natural or synthetic mediators ca...
Source: World Journal of Gastroenterology : WJG - June 28, 2020 Category: Gastroenterology Authors: Kamalian A, Sohrabi Asl M, Dolatshahi M, Afshari K, Shamshiri S, Momeni Roudsari N, Momtaz S, Rahimi R, Abdollahi M, Abdolghaffari AH Tags: World J Gastroenterol Source Type: research

Long noncoding RNAs in gastric cancer: From molecular dissection to clinical application.
Abstract Long noncoding RNAs (lncRNAs) are important regulators of cell processes that are usually dysregulated in gastric cancer (GC). Based on their high specificity and ease of detection in tissues and body fluids, increasing attention has spurred the study of the roles of lncRNAs in GC patients. Thus, it is necessary to elucidate the molecular mechanisms and further explore the clinical applications of lncRNAs in GC. In this review, we summarize current knowledge to examine dysregulated lncRNAs in GC and their underlying molecular mechanisms and activities in GC, which involve microRNA sponging, mRNA stability...
Source: World Journal of Gastroenterology : WJG - June 28, 2020 Category: Gastroenterology Authors: Gao Y, Wang JW, Ren JY, Guo M, Guo CW, Ning SW, Yu S Tags: World J Gastroenterol Source Type: research

Ultrasound liver elastography beyond liver fibrosis assessment.
Abstract Several guidelines have indicated that liver stiffness (LS) assessed by means of shear wave elastography (SWE) can safely replace liver biopsy in several clinical scenarios, particularly in patients with chronic viral hepatitis. However, an increase of LS may be due to some other clinical conditions not related to fibrosis, such as liver inflammation, acute hepatitis, obstructive cholestasis, liver congestion, infiltrative liver diseases. This review analyzes the role that SWE can play in cases of liver congestion due to right-sided heart failure, congenital heart diseases or valvular diseases. In patient...
Source: World Journal of Gastroenterology : WJG - June 28, 2020 Category: Gastroenterology Authors: Ferraioli G, Barr RG Tags: World J Gastroenterol Source Type: research

Recent progress in pulsed electric field ablation for liver cancer.
Abstract The number of liver cancer patients is likely to continue to increase in the coming decades due to the aging of the population and changing risk factors. Traditional treatments cannot meet the needs of all patients. New treatment methods evolved from pulsed electric field ablation are expected to lead to breakthroughs in the treatment of liver cancer. This paper reviews the safety and efficacy of irreversible electroporation in clinical studies, the methods to detect and evaluate its ablation effect, the improvements in equipment and its antitumor effect, and animal and clinical trials on electrochemother...
Source: World Journal of Gastroenterology : WJG - June 28, 2020 Category: Gastroenterology Authors: Liu ZG, Chen XH, Yu ZJ, Lv J, Ren ZG Tags: World J Gastroenterol Source Type: research

Hepatoprotective effects of Hovenia dulcis seeds against alcoholic liver injury and related mechanisms investigated via network pharmacology.
CONCLUSION: The results of this study demonstrate that H. dulcis seeds could be a good natural antioxidant source with protective effects on oxidative diseases such as ALD. PMID: 32655267 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 28, 2020 Category: Gastroenterology Authors: Meng X, Tang GY, Zhao CN, Liu Q, Xu XY, Cao SY Tags: World J Gastroenterol Source Type: research

Comparison of operative link for gastritis assessment, operative link on gastric intestinal metaplasia assessment, and TAIM stagings among men with atrophic gastritis.
Abstract BACKGROUND: Gastric cancer is the world's third most lethal malignancy. Most gastric cancers develop through precancerous states of atrophic gastritis and intestinal metaplasia. Two staging systems, operative link for gastritis assessment (OLGA) and operative link on gastric intestinal metaplasia assessment (OLGIM), have been developed to detect high gastric cancer risk. European guidelines recommend surveillance for high-risk OLGA/OLGIM patients (stages III-IV), and for those with advanced stage of atrophic gastritis in the whole stomach mucosa. We hypothesize, that by combining atrophy and intestinal me...
Source: World Journal of Gastroenterology : WJG - June 28, 2020 Category: Gastroenterology Authors: Nieminen AA, Kontto J, Puolakkainen P, Virtamo J, Kokkola A Tags: World J Gastroenterol Source Type: research

Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy.
Abstract BACKGROUND: Intraductal papillary mucinous neoplasms (IPMNs) are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma. Currently, the International Consensus Guidelines (ICG) for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography (CT) imaging. Despite using the ICG, it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection. A supplementary quantitative radiological tool, radiomics, may improve diagnostic accuracy of radiological evaluati...
Source: World Journal of Gastroenterology : WJG - June 28, 2020 Category: Gastroenterology Authors: Polk SL, Choi JW, McGettigan MJ, Rose T, Ahmed A, Kim J, Jiang K, Balagurunathan Y, Qi J, Farah PT, Rathi A, Permuth JB, Jeong D Tags: World J Gastroenterol Source Type: research

Transjugular intrahepatic portosystemic shunt for pyrrolizidine alkaloid-related hepatic sinusoidal obstruction syndrome.
Abstract BACKGROUND: Treatments for hepatic sinusoidal obstruction syndrome (HSOS) are limited. AIM: To evaluate transjugular intrahepatic portosystemic shunting (TIPS) as a treatment for pyrrolidine alkaloid-related HSOS (PA-HSOS). METHODS: This retrospective analysis included patients with PA-HSOS admitted to the First Affiliated Hospital of the University of Science and Technology of China (June 2015 to January 2019). Baseline clinical characteristics and follow-up data were extracted from the medical records. All patients included in this study experienced failure of initial therapy. Patients were di...
Source: World Journal of Gastroenterology : WJG - June 28, 2020 Category: Gastroenterology Authors: Zhou CZ, Wang RF, Lv WF, Fu YQ, Cheng DL, Zhu YJ, Hou CL, Ye XJ Tags: World J Gastroenterol Source Type: research

Evaluation of characteristics of left-sided colorectal perfusion in elderly patients by angiography.
CONCLUSION: The IMA and its branches are prone to arteriosclerosis, and IMA perfusion may be interrupted at the splenic flexure in elderly patients. The applicability and precision of preoperative angiography for evaluating the IMA branching and perfusion patterns could facilitate geriatric laparoscopic left-sided colorectal cancer surgery with suspicion of poor IMA perfusion. PMID: 32655271 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 28, 2020 Category: Gastroenterology Authors: Zhang C, Li A, Luo T, Li Y, Li F, Li J Tags: World J Gastroenterol Source Type: research

Clinical efficacy of the over-the-scope clip device: A systematic review.
CONCLUSION: This systematic review demonstrates that the OTSC system is a safe and effective endoscopic therapy to manage GI hemorrhage, perforations, anastomotic leaks, defects created by endoscopic resections and for stent fixation. Clinical success in fistula management appears limited. Further studies, including randomized controlled trials comparing OTSC with conventional and/or surgical therapies, are needed to determine which indication(s) are the most effective for its use. PMID: 32655272 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 28, 2020 Category: Gastroenterology Authors: Bartell N, Bittner K, Kaul V, Kothari TH, Kothari S Tags: World J Gastroenterol Source Type: research

Circulating exosomal miRNAs as potential biomarkers for Barrett's esophagus and esophageal adenocarcinoma.
Abstract Exosomes, a class of extracellular vesicles, are small membrane-bound vesicles derived from almost all cell types that can play important roles in intercellular communication. Exosomes contain proteins, lipids, and nucleic acids that are obtained from the parental cells and participate in various pathophysiological processes, including cell growth, migration, inflammation, immune regulation, and tumor pathogenesis. Moreover, exosomes might be applied in clinical settings, such as diagnosis, treatment, and outcome prediction of diseases, including various cancers. The incidence rates of Barrett's esophagus...
Source: World Journal of Gastroenterology : WJG - June 14, 2020 Category: Gastroenterology Authors: Lv J, Zhao HP, Dai K, Cheng Y, Zhang J, Guo L Tags: World J Gastroenterol Source Type: research

Ever-increasing diversity of drug-induced pancreatitis.
Abstract With over 100000 hospital admissions per annum, acute pancreatitis remains the leading gastrointestinal cause of hospitalization in the United States and has far-reaching impact well beyond. It has become increasingly recognized that drug-induced pancreatitis (DIP), despite accounting for less than 3% of all cases, represents an important and growing though often inconspicuous cause of acute pancreatitis. Nevertheless, knowledge of DIP is often curtailed by the limited availability of evidence needed to implicate given agents, especially for non-prescription medications. Indeed, the majority of available ...
Source: World Journal of Gastroenterology : WJG - June 14, 2020 Category: Gastroenterology Authors: Weissman S, Aziz M, Perumpail RB, Mehta TI, Patel R, Tabibian JH Tags: World J Gastroenterol Source Type: research

Nutrition in alcohol-related liver disease: Physiopathology and management.
Abstract Malnutrition encompassing both macro- and micro-nutrient deficiency, remains one of the most frequent complications of alcohol-related liver disease (ArLD). Protein-energy malnutrition can cause significant complications including sarcopenia, frailty and immunodepression in cirrhotic patients. Malnutrition reduces patient's survival and negatively affects the quality of life of individuals with ArLD. Moreover, nutritional deficit increases the likelihood of hepatic decompensation in cirrhosis. Prompt recognition of at-risk individuals, early diagnosis and treatment of malnutrition remains a key component ...
Source: World Journal of Gastroenterology : WJG - June 14, 2020 Category: Gastroenterology Authors: Kamran U, Towey J, Khanna A, Chauhan A, Rajoriya N, Holt A Tags: World J Gastroenterol Source Type: research

Liver-related effects of chronic hepatitis C antiviral treatment.
æk H Abstract More than five years ago, the treatment of hepatitis C virus infection was revolutionized with the introduction of all-oral direct-acting antiviral (DAA) drugs. They proved highly efficient in curing patients with chronic hepatitis C (CHC), including patients with cirrhosis. The new DAA treatments were alleged to induce significant improvements in clinical outcome and prognosis, but the exact cause of the expected benefit was unclear. Further, little was known about how the underlying liver disease would be affected during and after viral clearance. In this review, we describe and discuss the l...
Source: World Journal of Gastroenterology : WJG - June 14, 2020 Category: Gastroenterology Authors: Laursen TL, Sandahl TD, Kazankov K, George J, Grønbæk H Tags: World J Gastroenterol Source Type: research

Regenerative medicine of pancreatic islets.
Abstract The pancreas became one of the first objects of regenerative medicine, since other possibilities of dealing with the pancreatic endocrine insufficiency were clearly exhausted. The number of people living with diabetes mellitus is currently approaching half a billion, hence the crucial relevance of new methods to stimulate regeneration of the insulin-secreting β-cells of the islets of Langerhans. Natural restrictions on the islet regeneration are very tight; nevertheless, the islets are capable of physiological regeneration via β-cell self-replication, direct differentiation of multipotent progen...
Source: World Journal of Gastroenterology : WJG - June 14, 2020 Category: Gastroenterology Authors: Arutyunyan IV, Fatkhudinov TK, Makarov AV, Elchaninov AV, Sukhikh GT Tags: World J Gastroenterol Source Type: research

Benign gallbladder diseases: Imaging techniques and tips for differentiating with malignant gallbladder diseases.
Abstract Benign gallbladder diseases usually present with intraluminal lesions and localized or diffuse wall thickening. Intraluminal lesions of the gallbladder include gallstones, cholesterol polyps, adenomas, or sludge and polypoid type of gallbladder cancer must subsequently be excluded. Polyp size, stalk width, and enhancement intensity on contrast-enhanced ultrasound and degree of diffusion restriction may help differentiate cholesterol polyps and adenomas from gallbladder cancer. Localized gallbladder wall thickening is largely due to segmental or focal gallbladder adenomyomatosis, although infiltrative canc...
Source: World Journal of Gastroenterology : WJG - June 14, 2020 Category: Gastroenterology Authors: Yu MH, Kim YJ, Park HS, Jung SI Tags: World J Gastroenterol Source Type: research

COVID-19 pandemic: Its impact on liver disease and liver transplantation.
Abstract Severe pulmonary disease caused by the novel coronavirus [severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)], has devastated many countries around the world. It has overwhelmed the medical system. The priorities of many institutions have changed to manage critically ill corona virus infectious disease-2019 (COVID-19) patients, which affected the working style of many departments. Hepatologists and transplant surgeons look after a very sensitive patient group. Patients with liver disease need special attention and continuous follow-up. Similarly, transplant candidates also need special care. Hea...
Source: World Journal of Gastroenterology : WJG - June 14, 2020 Category: Gastroenterology Authors: Sahin TT, Akbulut S, Yilmaz S Tags: World J Gastroenterol Source Type: research

Diagnostic challenges in non-cirrhotic portal hypertension - porto sinusoidal vascular disease.
Abstract Non-cirrhotic portal hypertension consists of a group of diseases characterized by signs and complications of portal hypertension, which differ from cirrhosis through histological alterations, hemodynamic characterization and, clinical outcome. Because of the similarities in clinical presentation and imaging signs, frequently these patients, and particularly those with porto-sinusoidal vascular disease (PSVD), are misdiagnosed as having liver cirrhosis and thus raising difficulties in their diagnosis. The most challenging differentiation to be considered is between PSVD and cirrhosis and, although not pat...
Source: World Journal of Gastroenterology : WJG - June 14, 2020 Category: Gastroenterology Authors: Nicoară-Farcău O, Rusu I, Stefănescu H, Tanțău M, Badea RI, Procopeț B Tags: World J Gastroenterol Source Type: research

Extralevator abdominoperineal excision for advanced low rectal cancer: Where to go.
Abstract Since its introduction, extralevator abdominoperineal excision (ELAPE) in the prone position has gained significant attention and recognition as an important surgical procedure for the treatment of advanced low rectal cancer. Most studies suggest that because of adequate resection and precise anatomy, ELAPE could decrease the rate of positive circumferential resection margins, intraoperative perforation, and may further decrease local recurrence rate and improve survival. Some studies show that extensive resection of pelvic floor tissue may increase the incidence of wound complications and urogenital dysf...
Source: World Journal of Gastroenterology : WJG - June 14, 2020 Category: Gastroenterology Authors: Tao Y, Han JG, Wang ZJ Tags: World J Gastroenterol Source Type: research

High plasma levels of COL10A1 are associated with advanced tumor stage in gastric cancer patients.
Abstract BACKGROUND: Gastric cancer (GC) remains an aggressive malignancy with a high rate of mortality, being the third leading cause of cancer-related death. More than one million newly diagnosed cases and 782685 deaths due to GC were reported in 2018. GC is characterized by limited effective treatment options and the lack of consistent biomarkers for the diagnosis and prognosis of these patients. The discovery of new biomarkers useful in the early diagnosis of GC is mandatory. AIM: To evaluate the potential of COL10A1 as a circulating biomarker for the diagnosis and prognosis of gastric adenocarcinoma pati...
Source: World Journal of Gastroenterology : WJG - June 14, 2020 Category: Gastroenterology Authors: Necula L, Matei L, Dragu D, Pitica I, Neagu AI, Bleotu C, Dima S, Popescu I, Diaconu CC, Chivu-Economescu M Tags: World J Gastroenterol Source Type: research

Hsa_circRNA_102610 upregulation in Crohn's disease promotes transforming growth factor- β1-induced epithelial-mesenchymal transition via sponging of hsa-miR-130a-3p.
CONCLUSION: Hsa_circRNA_102610 upregulation in CD patients could promote the proliferation and EMT of intestinal epithelial cells via sponging of hsa-miR-130a-3p. PMID: 32587447 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2020 Category: Gastroenterology Authors: Yin J, Ye YL, Hu T, Xu LJ, Zhang LP, Ji RN, Li P, Chen Q, Zhu JY, Pang Z Tags: World J Gastroenterol Source Type: research

Optimal dosing time of Dachengqi decoction for protection of extrapancreatic organs in rats with experimental acute pancreatitis.
CONCLUSION: Delayed administration of DCQD might reduce pancreatic exocrine secretions and ameliorate pathological injury in the extrapancreatic organs of AP rats, demonstrating that the late time is the optimal dosing time. PMID: 32587448 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2020 Category: Gastroenterology Authors: Yao JQ, Zhu L, Miao YF, Zhu L, Chen H, Yuan L, Hu J, Yi XL, Wu QT, Yang XJ, Wan MH, Tang WF Tags: World J Gastroenterol Source Type: research

Single-nucleotide polymorphisms based genetic risk score in the prediction of pancreatic cancer risk.
Abstract BACKGROUND: Disease-related single nucleotide polymorphisms (SNPs) based genetic risk score (GRS) has been proven to provide independent inherited risk other than family history in multiple cancer types. AIM: To evaluate the potential of GRS in the prediction of pancreatic cancer risk. METHODS: In this case-control study (254 cases and 1200 controls), we aimed to evaluate the association between GRS and pancreatic ductal adenocarcinoma (PDAC) risk in the Chinese population. The GRS was calculated based on the genotype information of 18 PDAC-related SNPs for each study subject (personal genotypin...
Source: World Journal of Gastroenterology : WJG - June 14, 2020 Category: Gastroenterology Authors: Wang XY, Chen HT, Na R, Jiang DK, Lin XL, Yang F, Jin C, Fu DL, Xu JF Tags: World J Gastroenterol Source Type: research

Infection recurrence following minimally invasive treatment in patients with infectious pancreatic necrosis.
Abstract BACKGROUND: In recent decades, an increasing number of patients have received minimally invasive intervention for infected pancreatic necrosis (IPN) because of the benefits in reducing postoperative multiple organ failure and mortality. However, there are limited published data regarding infection recurrence after treatment of this patient population. AIM: To investigate the incidence and prediction of infection recurrence following successful minimally invasive treatment in IPN patients. METHODS: Medical records for 193 IPN patients, who underwent minimally invasive treatment between February 2...
Source: World Journal of Gastroenterology : WJG - June 14, 2020 Category: Gastroenterology Authors: Gao CC, Li J, Cao F, Wang XH, Li A, Wang Z, Li F Tags: World J Gastroenterol Source Type: research

Intestinal dysbiosis in pediatric Crohn's disease patients with IL10RA mutations.
CONCLUSION: In patients with IL10RA mutations and early onset inflammatory bowel disease, gut dysbiosis shows a moderate association with disease severity. PMID: 32587451 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2020 Category: Gastroenterology Authors: Xue AJ, Miao SJ, Sun H, Qiu XX, Wang SN, Wang L, Ye ZQ, Zheng CF, Huang ZH, Wang YH, Huang Y Tags: World J Gastroenterol Source Type: research

Giant splenic artery aneurysm presenting with massive upper gastrointestinal bleeding: A case report and review of literature.
CONCLUSION: The management of a ruptured giant SAA into the stomach can be successful with surgical approach. PMID: 32587452 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 14, 2020 Category: Gastroenterology Authors: Panzera F, Inchingolo R, Rizzi M, Biscaglia A, Schievenin MG, Tallarico E, Pacifico G, Di Venere B Tags: World J Gastroenterol Source Type: research

Cost of postoperative complications: How to avoid calculation errors.
This article describes how to quantify and classify PC using the Clavien-Dindo classification and the comprehensive complication index, discusses the perspectives from which economic evaluations are performed and the minimum postoperative follow-up established, and makes various recommendations. The availability of accurate and impartially audited data on PC will help reduce their incidence and bring down costs. Patients, the health authorities, and society as a whole are sure to benefit. PMID: 32550746 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2020 Category: Gastroenterology Authors: De la Plaza Llamas R, Ramia JM Tags: World J Gastroenterol Source Type: research

Tailored classification of portal vein thrombosis for liver transplantation: Focus on strategies for portal vein inflow reconstruction.
Abstract Portal vein thrombosis (PVT) is currently not considered a contraindication for liver transplantation (LT), but diffuse or complicated PVT remains a major surgical challenge. Here, we review the prevalence, natural course and current grading systems of PVT and propose a tailored classification of PVT in the setting of LT. PVT in liver transplant recipients is classified into three types, corresponding to three portal reconstruction strategies: Anatomical, physiological and non-physiological. Type I PVT can be removed via low dissection of the portal vein (PV) or thrombectomy; porto-portal anastomosis is t...
Source: World Journal of Gastroenterology : WJG - June 7, 2020 Category: Gastroenterology Authors: Teng F, Sun KY, Fu ZR Tags: World J Gastroenterol Source Type: research

Role of regenerating islet-derived proteins in inflammatory bowel disease.
Abstract Inflammatory bowel disease (IBD) is an inflammatory disorder of the gastrointestinal tract that affects millions of patients worldwide. It has a complex and multifactorial etiology leading to excessive exposure of intestinal epithelium to microbial antigens, inappropriate activation of the immune system and ultimately to the damage of intestinal tissues. Although numerous efforts have been made to improve the disease management, IBD remains persistently recurring and beyond cure. This is due largely to the gaps in our understanding of the pathogenesis of IBD that hamper the development of timely diagnoses...
Source: World Journal of Gastroenterology : WJG - June 7, 2020 Category: Gastroenterology Authors: Edwards JA, Tan N, Toussaint N, Ou P, Mueller C, Stanek A, Zinsou V, Roudnitsky S, Sagal M, Dresner L, Schwartzman A, Huan C Tags: World J Gastroenterol Source Type: research

Alternative uses of lumen apposing metal stents.
Abstract The advent of lumen apposing metal stents (LAMS) has revolutionized the management of many complex gastroenterological conditions that previously required surgical or radiological interventions. These procedures have garnered popularity due to their minimally invasive nature, higher technical and clinical success rate and lower rate of adverse events. By virtue of their unique design, LAMS provide more efficient drainage, serve as conduit for endoscopic access, are associated with lower rates of leakage and are easy to be removed. Initially used for drainage of pancreatic fluid collections, the use of LAM...
Source: World Journal of Gastroenterology : WJG - June 7, 2020 Category: Gastroenterology Authors: Sharma P, McCarty TR, Chhoda A, Costantino A, Loeser C, Muniraj T, Ryou M, Thompson CC Tags: World J Gastroenterol Source Type: research

Importance of investigating high-risk human papillomavirus in lymph node metastasis of esophageal adenocarcinoma.
Abstract High-risk human papillomavirus has been suggested as a risk factor for esophageal adenocarcinoma. Tumor human papillomavirus status has been reported to confer a favorable prognosis in esophageal adenocarcinoma. The size of the primary tumor and degree of lymphatic spread determines the prognosis of esophageal carcinomas. Lymph node status has been found to be a predictor of recurrent disease as well as 5-year survival in esophageal malignancies. In human papillomavirus driven cancers, e.g. cervical, anogenital, head and neck cancers, associated lymph nodes with a high viral load suggest metastatic lymph ...
Source: World Journal of Gastroenterology : WJG - June 7, 2020 Category: Gastroenterology Authors: Sharma P, Gautam SD, Rajendra S Tags: World J Gastroenterol Source Type: research

Post-transplant diabetes mellitus and preexisting liver disease - a bidirectional relationship affecting treatment and management.
Abstract Liver cirrhosis and diabetes mellitus (DM) are both common conditions with significant socioeconomic burden and impact on morbidity and mortality. A bidirectional relationship exists between DM and liver cirrhosis regarding both etiology and disease-related complications. Type 2 DM (T2DM) is a well-recognized risk factor for chronic liver disease and vice-versa, DM may develop as a complication of cirrhosis, irrespective of its etiology. Liver transplantation (LT) represents an important treatment option for patients with end-stage liver disease due to non-alcoholic fatty liver disease (NAFLD), which repr...
Source: World Journal of Gastroenterology : WJG - June 7, 2020 Category: Gastroenterology Authors: Cigrovski Berkovic M, Virovic-Jukic L, Bilic-Curcic I, Mrzljak A Tags: World J Gastroenterol Source Type: research

Vaccine therapy for dysbiosis-related diseases.
Abstract Progress in genomic analysis has resulted in the proposal that the intestinal microbiota is a crucial environmental factor in the development of multifactorial diseases, such as obesity, diabetes, rheumatoid arthritis, and inflammatory bowel diseases represented by Crohn's disease and ulcerative colitis. Dysregulated gut microbiome contributes to the pathogenesis of such disorders; however, there are few effective treatments for controlling only disease-mediating bacteria. Here, we review current knowledge about the intestinal microbiome in health and disease, and discuss a regulatory strategy using a par...
Source: World Journal of Gastroenterology : WJG - June 7, 2020 Category: Gastroenterology Authors: Fujimoto K, Uematsu S Tags: World J Gastroenterol Source Type: research

Gut microbiome in primary sclerosing cholangitis: A review.
Abstract Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by biliary inflammation and stricturing. Exploration of the pathogenesis of PSC in light of its association with inflammatory bowel disease (IBD) and the "gut-liver" axis is an emerging area of interest. A growing number of studies have begun to elucidate the role of the gut microbiota, its metabolites and its influence on host immune responses in the development of PSC and PSC-IBD. Studies of the fecal microbiota have highlighted enriched levels of certain species, including Veillonella, Streptococcus and ...
Source: World Journal of Gastroenterology : WJG - June 7, 2020 Category: Gastroenterology Authors: Little R, Wine E, Kamath BM, Griffiths AM, Ricciuto A Tags: World J Gastroenterol Source Type: research

Innate immune recognition and modulation in hepatitis D virus infection.
Abstract Hepatitis D virus (HDV) is a global health threat with more than 15 million humans affected. Current treatment options are largely unsatisfactory leaving chronically infected humans at high risk to develop liver cirrhosis and hepatocellular carcinoma. HDV is the only human satellite virus known. It encodes only two proteins, and requires Hepatitis B virus (HBV) envelope protein expression for productive virion release and spread of the infection. How HDV could evolve and why HBV was selected as a helper virus remains unknown. Since the discovery of Na+-taurocholate co-transporting polypeptide as the essen...
Source: World Journal of Gastroenterology : WJG - June 7, 2020 Category: Gastroenterology Authors: Jung S, Altstetter SM, Protzer U Tags: World J Gastroenterol Source Type: research

Use of zebrafish embryos as avatar of patients with pancreatic cancer: A new xenotransplantation model towards personalized medicine.
CONCLUSION: Our model seems to be effective for the xenotransplantation of PDAC tissue and evaluation of the effect of each chemotherapy scheme on the xenotransplanted tumor tissue. PMID: 32550755 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2020 Category: Gastroenterology Authors: Di Franco G, Usai A, Funel N, Palmeri M, Montesanti IER, Bianchini M, Gianardi D, Furbetta N, Guadagni S, Vasile E, Falcone A, Pollina LE, Raffa V, Morelli L Tags: World J Gastroenterol Source Type: research

Gan Shen Fu Fang ameliorates liver fibrosis in vitro and in vivo by inhibiting the inflammatory response and extracellular signal-regulated kinase phosphorylation.
CONCLUSION: GSFF inhibited liver fibrosis progression in vivo and HSC-T6 cell activation in vitro. These effects may be related to an alleviated inflammatory response and downregulated ERK phosphorylation. PMID: 32550756 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2020 Category: Gastroenterology Authors: Du QH, Zhang CJ, Li WH, Mu Y, Xu Y, Lowe S, Han L, Yu X, Wang SY, Li Y, Li J Tags: World J Gastroenterol Source Type: research

Periportal thickening on magnetic resonance imaging for hepatic fibrosis in infantile cholestasis.
Abstract BACKGROUND: Untreated neonatal cholestasis can progress to liver cirrhosis and end stage liver disease in infancy due to prolonged hepatocyte and biliary tree injury and may require liver transplantation. Therefore, non-invasive evaluation of hepatic fibrosis is important in infants with cholestasis. AIM: To investigate the usefulness of periportal thickening (PT) measured on liver magnetic resonance imaging (MRI) for the assessment of hepatic fibrosis in infants with cholestasis including biliary atresia (BA). METHODS: This retrospective study included infants less than 6 mo who underwent liver...
Source: World Journal of Gastroenterology : WJG - June 7, 2020 Category: Gastroenterology Authors: Lee MH, Shin HJ, Yoon H, Han SJ, Koh H, Lee MJ Tags: World J Gastroenterol Source Type: research

Successful robotic radical resection of hepatic echinococcosis located in posterosuperior liver segments.
CONCLUSION: Robotic radical surgery for cystic and selected alveolar echinococcosis in posterosuperior liver segments is safe and feasible. PMID: 32550758 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2020 Category: Gastroenterology Authors: Zhao ZM, Yin ZZ, Meng Y, Jiang N, Ma ZG, Pan LC, Tan XL, Chen X, Liu R Tags: World J Gastroenterol Source Type: research

Non-invasive prediction model for high-risk esophageal varices in the Chinese population.
CONCLUSION: The non-invasive prediction model for predicting HEVs in patients with viral cirrhosis was successfully established. The new model is reliable for predicting HEVs and has clinical applicability. PMID: 32550759 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2020 Category: Gastroenterology Authors: Yang LB, Xu JY, Tantai XX, Li H, Xiao CL, Yang CF, Zhang H, Dong L, Zhao G Tags: World J Gastroenterol Source Type: research

Golimumab in real-world practice in patients with ulcerative colitis: Twelve-month results.
erger S Abstract BACKGROUND: The introduction of biologics has revolutionized the management of the chronic inflammatory bowel disease, ulcerative colitis (UC), with many patients experiencing significant improvements not only in their symptoms but in other outcomes relevant to individuals and society as a whole. In Germany, there are no prospective data> 3 mo that assess the work productivity, daily activities and quality of life (QoL) of patients with moderate-to-severe UC treated with golimumab. AIM: To assess change in work productivity, capacity for daily activities and QoL in UC patients treated with...
Source: World Journal of Gastroenterology : WJG - June 7, 2020 Category: Gastroenterology Authors: Teich N, Grümmer H, Jörgensen E, Liceni T, Holtkamp-Endemann F, Fischer T, Hohenberger S Tags: World J Gastroenterol Source Type: research

M2BPGi for assessing liver fibrosis in patients with hepatitis C treated with direct-acting antivirals.
Abstract BACKGROUND: Assessing liver fibrosis is important for predicting the efficacy of direct-acting antivirals (DAAs) and patient prognosis. Non-invasive techniques to assess liver fibrosis are becoming important. Recently, serum Mac-2 binding protein glycosylation isomer (M2BPGi) was identified as a non-invasive marker of liver fibrosis. AIM: To investigate the diagnostic accuracy of M2BPGi in assessing liver fibrosis in patients with chronic hepatitis C (CHC) treated with DAAs. METHODS: From December 2017 to August 2018, 80 treatment-naïve adult patients with CHC who were eligible for DAAs the...
Source: World Journal of Gastroenterology : WJG - June 7, 2020 Category: Gastroenterology Authors: Saleh SA, Salama MM, Alhusseini MM, Mohamed GA Tags: World J Gastroenterol Source Type: research

Selective lateral lymph node dissection after neoadjuvant chemoradiotherapy in rectal cancer.
CONCLUSION: NCRT is not sufficient as a stand-alone therapy to eradicate LLN metastasis in lower rectal cancer patients and surgeons should consider performing selective LLND in patients with greater LLN SA diameter, poorer histological differentiation, or advanced T stage. Selective LLND for NCRT patients can have a favorable oncological outcome. PMID: 32550762 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2020 Category: Gastroenterology Authors: Chen JN, Liu Z, Wang ZJ, Mei SW, Shen HY, Li J, Pei W, Wang Z, Wang XS, Yu J, Liu Q Tags: World J Gastroenterol Source Type: research

Percutaneous endoscopic gastrostomy - Too often? Too late? Who are the right patients for gastrostomy?
Abstract Percutaneous endoscopic gastrostomy is an established method to provide nutrition to patients with restricted oral uptake of fluids and calories. Here, we review the methods, indications and complications of this procedure. While gastrostomy can be safely and easily performed during gastroscopy, the right patients and timing for this intervention are not always chosen. Especially in patients with dementia, the indication for and timing of gastrostomies are often improper. In this patient group, clear data for enteral nutrition are lacking; however, some evidence suggests that patients with advanced dement...
Source: World Journal of Gastroenterology : WJG - May 28, 2020 Category: Gastroenterology Authors: Dietrich CG, Schoppmeyer K Tags: World J Gastroenterol Source Type: research

Can adiponectin have an additional effect on the regulation of food intake by inducing gastric motor changes?
Abstract The regulation of food intake is a complex mechanism, and the hypothalamus is the main central structure implicated. In particular, the arcuate nucleus appears to be the most critical area in the integration of multiple peripheral signals. Among these signals, those originating from the white adipose tissue and the gastrointestinal tract are known to be involved in the regulation of food intake. The present paper focuses on adiponectin, an adipokine secreted by white adipose tissue, which is reported to have a role in the control of feeding by acting centrally. The recent observation that adiponectin is a...
Source: World Journal of Gastroenterology : WJG - May 28, 2020 Category: Gastroenterology Authors: Idrizaj E, Garella R, Squecco R, Baccari MC Tags: World J Gastroenterol Source Type: research

Diet in neurogenic bowel management: A viewpoint on spinal cord injury.
Abstract The aim of this review is to offer dietary advice for individuals with spinal cord injury (SCI) and neurogenic bowel dysfunction. With this in mind, we consider health conditions that are dependent on the level of lesion including skeletal muscle atrophy, autonomic dysreflexia and neurogenic bladder. In addition, SCI is often associated with a sedentary lifestyle, which increases risk for osteoporosis and diseases associated with chronic low-grade inflammation, including cardiovascular and chronic kidney diseases. The Mediterranean diet, along with exercise and dietary supplements, has been suggested as a...
Source: World Journal of Gastroenterology : WJG - May 28, 2020 Category: Gastroenterology Authors: Bernardi M, Fedullo AL, Bernardi E, Munzi D, Peluso I, Myers J, Lista FR, Sciarra T Tags: World J Gastroenterol Source Type: research

Role of gut microbiota-immunity axis in patients undergoing surgery for colorectal cancer: Focus on short and long-term outcomes.
Abstract Human body is colonized by a huge amount of microorganisms mostly located in the gastrointestinal tract. These dynamic communities, the environment and their metabolites constitute the microbiota. Growing data suggests a causal role of a dysbiotic microbiota in several pathologies, such as metabolic and neurological disorders, immunity dysregulations and cancer, especially the well-studied colorectal cancer development. However, many were preclinical studies and a complete knowledge of the pathogenetic mechanisms in humans is still absent. The gut microbiota can exert direct or indirect effects in differe...
Source: World Journal of Gastroenterology : WJG - May 28, 2020 Category: Gastroenterology Authors: Bartolini I, Risaliti M, Ringressi MN, Melli F, Nannini G, Amedei A, Muiesan P, Taddei A Tags: World J Gastroenterol Source Type: research