Log in to search using one of your social media accounts:

 

Defining and predicting deep remission in patients with perianal fistulizing Crohn's disease on anti-tumor necrosis factor therapy.
Abstract Perianal fistulas can occur to up to one-third of patients with Crohn's disease (CD) leading to significant disabling disease and morbidity. Fistulising perianal CD treatment often necessitates a combined pharmacological and surgical approach. Anti-tumor necrosis factor (anti-TNF) therapy, particularly infliximab, has been shown to be very effective for both perianal and internal fistulising CD. Nevertheless, current data suggest that sustained remission and long-term complete fistula healing can be achieved in only 30% to 50% of patients. Moreover, these percentages refer mostly to clinical rather than d...
Source: World Journal of Gastroenterology : WJG - September 14, 2017 Category: Gastroenterology Authors: Papamichael K, Cheifetz AS Tags: World J Gastroenterol Source Type: research

Evidences supporting the vascular etiology of post-double balloon enteroscopy pancreatitis: Study in porcine model.
drado-Martínez E Abstract Double balloon enteroscopy (DBE) is an endoscopic technique broadly used to diagnose and treat small bowel diseases. Among the associated complications of the oral DBE, post-procedure pancreatitis has taken the most attention due to its gravity and the thought that it might be associated to the technique itself and anatomical features of the pancreas. However, as the etiology has not been clarified yet, this paper aims to review the published literature and adds new results from a porcine animal model. Biochemical markers, histological sections and the vascular perfusion of the pan...
Source: World Journal of Gastroenterology : WJG - September 14, 2017 Category: Gastroenterology Authors: Latorre R, López-Albors O, Soria F, Morcillo E, Esteban P, Pérez-Cuadrado-Robles E, Pérez-Cuadrado-Martínez E Tags: World J Gastroenterol Source Type: research

Circulating inflammatory factors associated with worse long-term prognosis in colorectal cancer.
CONCLUSION: High plasma levels of inflammatory factors are associated with increased risk of mortality among CRC patients and could be potential biomarkers for revealing prognosis. PMID: 28974887 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 14, 2017 Category: Gastroenterology Authors: Olsen RS, Nijm J, Andersson RE, Dimberg J, Wågsäter D Tags: World J Gastroenterol Source Type: research

Moxibustion eases chronic inflammatory visceral pain through regulating MEK, ERK and CREB in rats.
Abstract AIM: To investigate the effects of herb-partitioned moxibustion (HPM) on phosphorylation of mitogen-activated extracellular signal-regulated kinase (MEK)1, extracellular signal-regulated kinase (ERK)1/2 and cAMP response element binding protein (CREB) in spinal cord of rats with chronic inflammatory visceral pain (CIVP), and to explore the central mechanism of HPM in treating CIVP. METHODS: Male Sprague-Dawley rats were randomized into normal, model, HPM, sham-HPM, MEK-inhibitor and dimethyl sulfoxide (DMSO) groups. The CIVP model was established using an enema mixture of trinitrobenzene sulfonic aci...
Source: World Journal of Gastroenterology : WJG - September 14, 2017 Category: Gastroenterology Authors: Li ZY, Huang Y, Yang YT, Zhang D, Zhao Y, Hong J, Liu J, Wu LJ, Zhang CH, Wu HG, Zhang J, Ma XP Tags: World J Gastroenterol Source Type: research

Changes of Ghrelin/GOAT axis and mTOR pathway in the hypothalamus after sleeve gastrectomy in obese type-2 diabetes rats.
Abstract AIM: To examine the changes of the ghrelin/ghrelin O-acyltransferase (GOAT) axis and the mammalian target of rapamycin (mTOR) pathway in the hypothalamus after sleeve gastrectomy. METHODS: A total of 30 obese type-2 diabetes Sprague-Dawley (SD) rats, 6 wk of age, fed with high-sugar and high-fat fodder for 2 mo plus intraperitoneal injection of streptozotocin were randomly divided into three groups: non-operation group (S0 group, n = 10), sham operation group (Sh group, n = 10) and sleeve gastrectomy group (SG group, n = 10). Data of body mass, food intake, oral glucose tolerance test (OGTT), acylate...
Source: World Journal of Gastroenterology : WJG - September 14, 2017 Category: Gastroenterology Authors: Wang Q, Tang W, Rao WS, Song X, Shan CX, Zhang W Tags: World J Gastroenterol Source Type: research

Dihydromyricetin-mediated inhibition of the Notch1 pathway induces apoptosis in QGY7701 and HepG2 hepatoma cells.
CONCLUSION: Notch1 is involved in the development of HCC and DHM inhibits cell proliferation and promotes apoptosis by down-regulating the expression of Notch1. PMID: 28974890 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 14, 2017 Category: Gastroenterology Authors: Lu CJ, He YF, Yuan WZ, Xiang LJ, Zhang J, Liang YR, Duan J, He YH, Li MY Tags: World J Gastroenterol Source Type: research

Curcumin inhibits hepatitis B virus infection by down-regulating cccDNA-bound histone acetylation.
Abstract AIM: To investigate the potential effect of curcumin on hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) and the underlying mechanism. METHODS: A HepG2.2.15 cell line stably transfected with HBV was treated with curcumin, and HBV surface antigen (HBsAg) and e antigen (HBeAg) expression levels were assessed by ELISA. Intracellular HBV DNA replication intermediates and cccDNA were detected by Southern blot and real-time PCR, respectively. The acetylation levels of histones H3 and H4 were measured by Western blot. H3/H4-bound cccDNA was detected by chromatin immunoprecipitation (ChIP) ass...
Source: World Journal of Gastroenterology : WJG - September 14, 2017 Category: Gastroenterology Authors: Wei ZQ, Zhang YH, Ke CZ, Chen HX, Ren P, He YL, Hu P, Ma DQ, Luo J, Meng ZJ Tags: World J Gastroenterol Source Type: research

Systemic immune-inflammation index for predicting prognosis of colorectal cancer.
Abstract AIM: To investigate the clinical significance of preoperative systemic immune-inflammation index (SII) in patients with colorectal cancer (CRC). METHODS: A retrospective analysis of 1383 cases with CRC was performed following radical surgery. SII was calculated with the formula SII = (P × N)/L, where P, N, and L refer to peripheral platelet, neutrophil, and lymphocyte counts, respectively. The clinicopathological features and follow-up data were evaluated to compare SII with other systemic inflammation-based prognostic indices such as the neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyt...
Source: World Journal of Gastroenterology : WJG - September 14, 2017 Category: Gastroenterology Authors: Chen JH, Zhai ET, Yuan YJ, Wu KM, Xu JB, Peng JJ, Chen CQ, He YL, Cai SR Tags: World J Gastroenterol Source Type: research

Predictive factors for the failure of endoscopic stent-in-stent self-expandable metallic stent placement to treat malignant hilar biliary obstruction.
CONCLUSION: A large angle was identified as a predictive factor for failure of stent-in-stent SEMS placement. PMID: 28974893 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 14, 2017 Category: Gastroenterology Authors: Sugimoto M, Takagi T, Suzuki R, Konno N, Asama H, Watanabe K, Nakamura J, Kikuchi H, Waragai Y, Takasumi M, Sato Y, Hikichi T, Ohira H Tags: World J Gastroenterol Source Type: research

Assessment of colon polyp morphology: Is education effective?
CONCLUSION: The education program used in this study can improve inter-observer agreement and diagnostic accuracy in assessing the morphology of colon polyps; it is especially effective when first learning endoscopy. PMID: 28974894 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 14, 2017 Category: Gastroenterology Authors: Kim JH, Nam KS, Kwon HJ, Choi YJ, Jung K, Kim SE, Moon W, Park MI, Park SJ Tags: World J Gastroenterol Source Type: research

Body mass index does not affect the survival of pancreatic cancer patients.
Abstract AIM: To evaluate the association of body mass index (BMI) with the overall survival of pancreatic ductal adenocarcinoma (PDAC) patients. METHODS: A retrospective analysis of PDAC patients diagnosed in the National Cancer Center of China between January 1999 and December 2014 was performed. These patients were categorized into four BMI groups (
Source: World Journal of Gastroenterology : WJG - September 14, 2017 Category: Gastroenterology Authors: Jiang QL, Wang CF, Tian YT, Huang H, Zhang SS, Zhao DB, Ma J, Yuan W, Sun YM, Che X, Zhang JW, Chu YM, Zhang YW, Chen YT Tags: World J Gastroenterol Source Type: research

Access to biologicals in Crohn's disease in ten European countries.
CONCLUSION: Substantial inequalities in access to biologicals were largely associated with GDP. To explain differences in access among countries with similar development needs further research on acceptance. PMID: 28974896 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 14, 2017 Category: Gastroenterology Authors: Péntek M, Lakatos PL, Oorsprong T, Gulácsi L, Pavlova M, Groot W, Rencz F, Brodszky V, Baji P, Crohn's Disease Research Group Tags: World J Gastroenterol Source Type: research

Temporal trends in the misdiagnosis rates between Crohn's disease and intestinal tuberculosis.
Abstract AIM: To investigate the temporal trends in the misdiagnosis rate between Crohn's disease (CD) and intestinal tuberculosis (ITB) in South Korea. METHODS: We retrospectively reviewed the medical records of patients managed for CD or ITB at Asan Medical Center, a tertiary referral hospital, Seoul, Korea between 1996 and 2014. The temporal trends in the misdiagnosis rates between the two diseases were analyzed. The demographic and clinical characteristics were compared between CD patients who were initially misdiagnosed as ITB (final CD group) and vice versa (final ITB group). Final diagnostic criteria f...
Source: World Journal of Gastroenterology : WJG - September 14, 2017 Category: Gastroenterology Authors: Seo H, Lee S, So H, Kim D, Kim SO, Soh JS, Bae JH, Lee SH, Hwang SW, Park SH, Yang DH, Kim KJ, Byeon JS, Myung SJ, Yang SK, Ye BD Tags: World J Gastroenterol Source Type: research

Detection of metastatic cancer cells in mesentery of colorectal cancer patients.
CONCLUSION: Metastasis V might be associated with a poor prognosis of CRC patients. PMID: 28974898 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 14, 2017 Category: Gastroenterology Authors: Luo XL, Xie DX, Wu JX, Wu AD, Ge ZQ, Li HJ, Hu JB, Cao ZX, Gong JP Tags: World J Gastroenterol Source Type: research

Natural history of covert hepatic encephalopathy: An observational study of 366 cirrhotic patients.
Abstract AIM: To explore the natural history of covert hepatic encephalopathy (CHE) in absence of medication intervention. METHODS: Consecutive outpatient cirrhotic patients in a Chinese tertiary care hospital were enrolled and evaluated for CHE diagnosis. They were followed up for a mean of 11.2 ± 1.3 mo. Time to the first cirrhosis-related complications requiring hospitalization, including overt HE (OHE), resolution of CHE and death/transplantation, were compared between CHE and no-CHE patients. Predictors for complication(s) and death/transplantation were also analyzed. RESULTS: A total of 366 ...
Source: World Journal of Gastroenterology : WJG - September 14, 2017 Category: Gastroenterology Authors: Wang AJ, Peng AP, Li BM, Gan N, Pei L, Zheng XL, Hong JB, Xiao HY, Zhong JW, Zhu X Tags: World J Gastroenterol Source Type: research

Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer.
Abstract AIM: To determine whether circular RNAs (circRNAs) are involved in pathological processes of gastric cancer (GC). METHODS: Three circRNAs with differential expression in GC and colorectal cancer were randomly selected for validation by quantitative reverse transcription-polymerase chain reaction (qRT-PCR), using 20 pairs of gastric tissues and normal tissues. Based on the predicted circRNA-miRNA network, we then focused on hsa_circ_0000745, which was found to be down-regulated in 20 GC tissues compared with normal tissues. The hsa_circ_0000745 levels were further analyzed by qRT-PCR in 60 GC tissues ...
Source: World Journal of Gastroenterology : WJG - September 14, 2017 Category: Gastroenterology Authors: Huang M, He YR, Liang LC, Huang Q, Zhu ZQ Tags: World J Gastroenterol Source Type: research

P2Y1R is involved in visceral hypersensitivity in rats with experimental irritable bowel syndrome.
Abstract AIM: To evaluate the role of P2Y1R in visceral hypersensitivity in rats with experimental irritable bowel syndrome. METHODS: A rat model of irritable bowel syndrome was generated by intra-colonic administration of acetic acid (AA) and assessed by histology and myeloperoxidase (MPO) activity assay. Then P2Y1R expression in the colonic tissue was detected by Western blot. In order to explore the regulatory role of P2Y1R in visceral hypersensitivity, an agonist (MRS2365) and an antagonist (MRS2179) of P2Y1R were intra-colonically administered and effects were tested through a colorectal distension test....
Source: World Journal of Gastroenterology : WJG - September 14, 2017 Category: Gastroenterology Authors: Wu J, Cheng Y, Zhang R, Liu D, Luo YM, Chen KL, Ren S, Zhang J Tags: World J Gastroenterol Source Type: research

Randomized controlled trial of uncut Roux-en-Y vs Billroth II reconstruction after distal gastrectomy for gastric cancer: Which technique is better for avoiding biliary reflux and gastritis?
CONCLUSION: Compared with Billroth II reconstruction, uncut Roux-en-Y reconstruction is secure and feasible, and can effectively reduce the incidence of alkaline reflux, residual gastritis, and heartburn. Despite the incidence of recanalization, uncut Roux-en-Y should be widely applied. PMID: 28974902 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 14, 2017 Category: Gastroenterology Authors: Yang D, He L, Tong WH, Jia ZF, Su TR, Wang Q Tags: World J Gastroenterol Source Type: research

Drainage fluid and serum amylase levels accurately predict development of postoperative pancreatic fistula.
Abstract AIM: To investigate potential biomarkers for predicting postoperative pancreatic fistula (POPF) after pancreaticoduodenectomy (PD). METHODS: We prospectively recruited 83 patients to this study. All patients underwent PD (Child's procedure) at the Division of Hepatobiliary and Pancreas Surgery at the First Bethune Hospital of Jilin University between June 2011 and April 2015. Data pertaining to demographic variables, clinical characteristics, texture of pancreas, surgical approach, histopathological results, white blood cell count, amylase and choline levels in the serum, pancreatic/gastric drainage ...
Source: World Journal of Gastroenterology : WJG - September 14, 2017 Category: Gastroenterology Authors: Jin S, Shi XJ, Wang SY, Zhang P, Lv GY, Du XH, Wang GY Tags: World J Gastroenterol Source Type: research

Interventional endoscopic ultrasound for a symptomatic pseudocyst secondary to gastric heterotopic pancreas.
Abstract Heterotopic pancreas (HP) is a relatively uncommon entity that is defined as pancreatic tissue without a true anatomical or vascular connection to the pancreas. HP does not cause symptoms in most cases but can occasionally produce various manifestations, including nausea, vomiting, abdominal pain, and even heterotopic pancreatitis. Here, we report an unusual case in which heterotopic pancreatitis complicated by the formation of a pseudocyst that caused gastric outlet obstruction was diagnosed based on serum hyperamylasemia and findings from endoscopic ultrasonography (EUS)-guided fine needle aspiration (E...
Source: World Journal of Gastroenterology : WJG - September 14, 2017 Category: Gastroenterology Authors: Jin HB, Lu L, Yang JF, Lou QF, Yang J, Shen HZ, Tang XW, Zhang XF Tags: World J Gastroenterol Source Type: research

Helminths as an alternative therapy for intestinal diseases.
Abstract Animal models and clinical studies have shown that helminth infections exert immunomodulatory activity, altering intestinal permeability and providing a potential beneficial action on autoimmune and inflammatory disorders in human beings, such as inflammatory bowel disease (IBD) and celiac disease. This is consistent with the theory that intestinal microbiota is responsible for shaping human immunological responses. With the arrival of the immunobiologic era and the use of antibodies, we propose a distinctive pathway for treating patients with IBD and celiac disease. We have some evidence about the safety...
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Sipahi AM, Baptista DM Tags: World J Gastroenterol Source Type: research

Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis.
Abstract Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are complex diseases that result from the chronic dysregulated immune response in the gastrointestinal tract. The exact etiology is not fully understood, but it is accepted that it occurs when an inappropriate aggressive inflammatory response in a genetically susceptible host due to inciting environmental factors occurs. To investigate the pathogenesis and etiology of human IBD, various animal models of IBD have been developed that provided indispensable insights into the histopathological and morphological changes as wel...
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Eichele DD, Kharbanda KK Tags: World J Gastroenterol Source Type: research

Autoimmune hepatitis: Standard treatment and systematic review of alternative treatments.
Abstract Autoimmune hepatitis is a rare chronic inflammatory liver disease, affecting all ages, characterised by elevated transaminase and immunoglobulin G levels, positive autoantibodies, interface hepatitis at liver histology and good response to immunosuppressive treatment. If untreated, it has a poor prognosis. The aim of this review is to summarize the evidence for standard treatment and to provide a systematic review on alternative treatments for adults and children. Standard treatment is based on steroids and azathioprine, and leads to disease remission in 80%-90% of patients. Alternative first line treatme...
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Terziroli Beretta-Piccoli B, Mieli-Vergani G, Vergani D Tags: World J Gastroenterol Source Type: research

Colorectal cancer, screening and primary care: A mini literature review.
Abstract Colorectal cancer (CRC) is a common health problem, representing the third most commonly diagnosed cancer worldwide and causing a significant burden in terms of morbidity and mortality, with annual deaths estimated at 700000. The western way of life, that is being rapidly adopted in many regions of the world, is a well discussed risk factor for CRC and could be targeted in terms of primary prevention. Furthermore, the relatively slow development of this cancer permits drastic reduction of incidence and mortality through secondary prevention. These facts underlie primary care physicians (PCPs) being assign...
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Hadjipetrou A, Anyfantakis D, Galanakis CG, Kastanakis M, Kastanakis S Tags: World J Gastroenterol Source Type: research

Behavioral gastroenterology: An emerging system and new frontier of action.
Abstract Behavioral gastroenterology is a new interdisciplinary science that explores the influence of unhealthy lifestyles and psychological factors on the digestive system and addresses the prevention, diagnosis, treatment, and rehabilitation of digestive diseases. Moreover, the concept of whole-course intervention with a focus on disease prevention and a new model of integrated therapy based on alterations of lifestyle and psychology are being gradually established. This paradigm may substantively impact the prevention and treatment of digestive diseases. PMID: 28970721 [PubMed - in process] (Source: World...
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Jia L, Jiang SM, Liu J Tags: World J Gastroenterol Source Type: research

Pharmacological evaluation of NSAID-induced gastropathy as a "Translatable" model of referred visceral hypersensitivity.
CONCLUSION: Together, these findings implicate opioid receptors, GC-C, and sodium and TRP channel activation as possible mechanisms associated with visceral hypersensitivity. More importantly, these findings also validate NSAID-induced gastropathy as a sensitive and clinically predictive mouse model suitable for assessing novel molecules with potential pain-attenuating properties. PMID: 28970722 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Hummel M, Knappenberger T, Reilly M, Whiteside GT Tags: World J Gastroenterol Source Type: research

High yield reproducible rat model recapitulating human Barrett's carcinogenesis.
CONCLUSION: Esophagojejunostomy was successfully replicated in rats with low mortality and a high tumor burden, which may facilitate broader adoption to study EAC development, progression, and therapeutics. PMID: 28970723 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Matsui D, Omstead AN, Kosovec JE, Komatsu Y, Lloyd EJ, Raphael H, Kelly RJ, Zaidi AH, Jobe BA Tags: World J Gastroenterol Source Type: research

Changes in expression of inhibitory substances in the intramural neurons of the stomach following streptozotocin- induced diabetes in the pig.
CONCLUSION: Our results support the hypothesis that in the course of diabetes, long term episodes of high glucose serum level may influence the chemical phenotyping of enteric neurons. PMID: 28970724 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Bulc M, Palus K, Zielonka Ł, Gajęcka M, Całka J Tags: World J Gastroenterol Source Type: research

HOX transcript antisense intergenic RNA represses E-cadherin expression by binding to EZH2 in gastric cancer.
Abstract AIM: To clarify the mechanisms of HOX transcript antisense intergenic RNA (HOTAIR) in gastric cancer (GC) migration and invasion. METHODS: Quantitative real-time polymerase chain reaction (qPCR) was used to detect the expression level of HOTAIR in GC tissues. The correlation of its expression with clinicopathological features was analyzed. Area under receiver operating characteristic curve (AUCROC) was constructed to evaluate the diagnostic value of HOTAIR. Wound-healing assay and Transwell assay were performed to detect the biological effects of HOTAIR in GC cells. qPCR, western blot and immunohisto...
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Chen WM, Chen WD, Jiang XM, Jia XF, Wang HM, Zhang QJ, Shu YQ, Zhao HB Tags: World J Gastroenterol Source Type: research

Ca(2+)/calmodulin-dependent protein kinase II regulates colon cancer proliferation and migration via ERK1/2 and p38 pathways.
CONCLUSION: Our findings highlight CaMKII as a potential critical mediator in human colon tumor development and metastasis. PMID: 28970726 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Chen W, An P, Quan XJ, Zhang J, Zhou ZY, Zou LP, Luo HS Tags: World J Gastroenterol Source Type: research

Aberrant DNA-PKcs and ERGIC1 expression may be involved in initiation of gastric cancer.
Abstract AIM: To investigate the molecular mechanisms of gastric carcinogenesis. METHODS: We used label-free quantification technology integrated with liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis to identify differentially expressed proteins in 160 specimens of normal gastric mucosa, gastric mucosa with mild dysplasia, moderate dysplasia, severe dysplasia, and early mucosal gastric cancer (GC) collected at the Second Hospital of Lanzhou University from 2010 to 2015. Immunohistochemistry was used to verify the differentially expressed proteins detected by LC-MS/MS. RESULTS: With a th...
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Wang FR, Wei YC, Han ZJ, He WT, Guan XY, Chen H, Li YM Tags: World J Gastroenterol Source Type: research

Real-world treatment patterns of gastrointestinal neuroendocrine tumors: A claims database analysis.
CONCLUSION: In this study, 60% of patients initiated treatment with SSA alone or in combination. The relatively long time to discontinuation suggests possible sustained effectiveness and tolerability. PMID: 28970728 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Benson Iii AB, Broder MS, Cai B, Chang E, Neary MP, Papoyan E Tags: World J Gastroenterol Source Type: research

Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases.
Abstract AIM: To investigate whether immune mediated diseases (IMD) are more frequent in patients with inflammatory bowel disease (IBD). METHODS: In this population based registry study, a total of 47325 patients with IBD were alive and registered in the Danish National Patient Registry on December 16, 2013. Controls were randomly selected from the Danish Civil Registration System (CRS) and matched for sex, age, and municipality. We used ICD 10 codes to identify the diagnoses of the included patients. The IBD population was divided into three subgroups: Ulcerative colitis (UC), Crohn's disease (CD) and Both t...
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Halling ML, Kjeldsen J, Knudsen T, Nielsen J, Hansen LK Tags: World J Gastroenterol Source Type: research

Suspicious brush cytology is an indication for liver transplantation evaluation in primary sclerosing cholangitis.
CONCLUSION: Repeated suspicion of neoplasia in brush cytology should be an indication for evaluations of liver transplantation prior to the development of CCA. PMID: 28970730 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Boyd S, Vannas M, Jokelainen K, Isoniemi H, Mäkisalo H, Färkkilä MA, Arola J Tags: World J Gastroenterol Source Type: research

Management of gastric mucosa-associated lymphoid tissue lymphoma in patients with extra copies of the MALT1 gene.
CONCLUSION: Patients with t(11;18) translocation should be treated differently from others. Patients with extra copies of MALT1 could be initially treated with H. pylori eradication, similar to patients without t(11;18) translocation or extra copies of MALT1. PMID: 28970731 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Iwamuro M, Takenaka R, Nakagawa M, Moritou Y, Saito S, Hori S, Inaba T, Kawai Y, Toyokawa T, Tanaka T, Yoshino T, Okada H Tags: World J Gastroenterol Source Type: research

Ketogenic diet poses a significant effect on imbalanced gut microbiota in infants with refractory epilepsy.
CONCLUSION: GM pattern in healthy infants differed dramatically from that of the epileptic group. KD could significantly modify symptoms of epilepsy and reshape the GM of epileptic infants. PMID: 28970732 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Xie G, Zhou Q, Qiu CZ, Dai WK, Wang HP, Li YH, Liao JX, Lu XG, Lin SF, Ye JH, Ma ZY, Wang WJ Tags: World J Gastroenterol Source Type: research

Definition of colorectal anastomotic leakage: A consensus survey among Dutch and Chinese colorectal surgeons.
CONCLUSION: There is no universally accepted definition of CAL in the Netherlands and China. Diagnosis of CAL based on clinical manifestations remains a point of discussion in both countries. Dutch surgeons are more likely to report 'subclinical' leaks as CAL, which partly explains the higher reported Dutch CAL rates. PMID: 28970733 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: van Rooijen SJ, Jongen AC, Wu ZQ, Ji JF, Slooter GD, Roumen RM, Bouvy ND Tags: World J Gastroenterol Source Type: research

How to treat intestinal obstruction due to malignant recurrence after Whipple's resection for pancreatic head cancer: Description of 2 new endoscopic techniques.
We describe two new endoscopic techniques to treat a malignant intestinal obstruction with the insertion of a SEMS into the afferent limb and the alimentary limb. A case of malignant gastric outlet obstruction after a Whipple's resection was treated by the creation of an endoscopic gastrojejunostomy by the insertion of a lumen apposing HotAxios stent in between the stomach and the alimentary limb under fluoroscopic and endoscopic ultrasound control. Biliary obstruction and jaundice caused by a malignant stricture of the afferent limb after a Roux-en-Y Whipple's resection was treated by the insertion of a SEMS by means of t...
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Mouradides C, Taha A, Borbath I, Deprez PH, Moreels TG Tags: World J Gastroenterol Source Type: research

Arterioportal shunt incidental to treatment with oxaliplatin that mimics recurrent gastric cancer.
Abstract Arterioportal shunt (APS) is an organic communication between the hepatic arterial system and the portal venous system. The APS is one of the major causes of transient hepatic attenuation differences on dynamic computed tomography (CT) or magnetic resonance imaging (MRI). This condition is usually associated with trauma, liver cirrhosis, and malignancies of the liver. However, there has been no report about oxaliplatin-induced APS. A 41-year-old male was diagnosed with Stage IIIB gastric cancer. The patient initially underwent neoadjuvant chemotherapy with capecitabine and oxaliplatin After 3 cycles of th...
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Kim HB, Park SG Tags: World J Gastroenterol Source Type: research

Comment on "Effect of biofilm formation by clinical isolates of Helicobacter pylori on the efflux-mediated resistance to commonly used antibiotics".
In conclusion, we provide additional data regarding the role of specific innate immune molecules in antibiotic cross-resistance mechanisms that may deepen our understanding in the context of the development of novel eradication regimens. PMID: 28970736 [PubMed - indexed for MEDLINE] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Kazakos EI, Dorrell N, Polyzos SA, Deretzi G, Kountouras J Tags: World J Gastroenterol Source Type: research

Role of tissue microenvironment resident adipocytes in colon cancer.
Abstract Colorectal cancer (CRC) is a multifactorial disease characterized by several genetic and epigenetic alterations occurring in epithelial cells. It is increasingly recognized that tumour progression is also regulated by tumour microenvironment (TME). The bidirectional cross-talk between tumour resident adipocytes and cancer cells within TME has been proposed as active contributor to carcinogenesis. Tumour resident adipocytes exhibit an activated phenotype characterized by increased secretion of pro-tumorigenic factors (angiogenic/inflammatory/immune) which contribute to cancer cell proliferation, invasion, ...
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Tabuso M, Homer-Vanniasinkam S, Adya R, Arasaradnam RP Tags: World J Gastroenterol Source Type: research

Ophthalmic manifestations in patients with inflammatory bowel disease: A review.
Abstract Clinical manifestations of inflammatory bowel disease (IBD) are not locally restricted to the gastrointestinal tract, and a significant portion of patients have involvement of other organs and systems. The visual system is one of the most frequently affected, mainly by inflammatory disorders such as episcleritis, uveitis and scleritis. A critical review of available literature concerning ocular involvement in IBD, as it appears in PubMed, was performed. Episcleritis, the most common ocular extraintestinal manifestation (EIM), seems to be more associated with IBD activity when compared with other ocular EI...
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Troncoso LL, Biancardi AL, de Moraes HV, Zaltman C Tags: World J Gastroenterol Source Type: research

Laparoscopic appendectomy for acute appendicitis: How to discourage surgeons using inadequate therapy.
Abstract Acute appendicitis (AA) develops in a progressive and irreversible manner, even if the clinical course of AA can be temporarily modified by intentional medications. Reliable and real-time diagnosis of AA can be made based on findings of the white blood cell count and enhanced computed tomography. Emergent laparoscopic appendectomy (LA) is considered as the first therapeutic choice for AA. Interval/delayed appendectomy at 6-12 wk after disease onset is considered as unsafe with a high recurrent rate during the waiting time. However, this technique may have some advantages for avoiding unnecessary extended ...
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Hori T, Machimoto T, Kadokawa Y, Hata T, Ito T, Kato S, Yasukawa D, Aisu Y, Kimura Y, Sasaki M, Takamatsu Y, Kitano T, Hisamori S, Yoshimura T Tags: World J Gastroenterol Source Type: research

Long non-coding RNAs in hepatocellular carcinoma: Potential roles and clinical implications.
Abstract Long non-coding RNAs (lncRNAs) are a subgroup of non-coding RNA transcripts greater than 200 nucleotides in length with little or no protein-coding potential. Emerging evidence indicates that lncRNAs may play important regulatory roles in the pathogenesis and progression of human cancers, including hepatocellular carcinoma (HCC). Certain lncRNAs may be used as diagnostic or prognostic markers for HCC, a serious malignancy with increasing morbidity and high mortality rates worldwide. Therefore, elucidating the functional roles of lncRNAs in tumors can contribute to a better understanding of the molecular m...
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Niu ZS, Niu XJ, Wang WH Tags: World J Gastroenterol Source Type: research

Nano albumin bound-paclitaxel in pancreatic cancer: Current evidences and future directions.
Abstract Pancreatic cancer (PDAC) is an aggressive and chemoresistant disease, representing the fourth cause of cancer related deaths in western countries. Majority of patients have unresectable, locally advanced or metastatic disease at time of diagnosis and the 5-year survival rate in these conditions is extremely low. For more than a decade gemcitabine has been the cornerstone of metastatic PDAC treatment, although survival benefit was very poor. PDAC cells are surrounded by an intense desmoplastic reaction that may create a barrier to the drugs penetration within the tumor. Recently PDAC stroma has been addres...
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Giordano G, Pancione M, Olivieri N, Parcesepe P, Velocci M, Di Raimo T, Coppola L, Toffoli G, D'Andrea MR Tags: World J Gastroenterol Source Type: research

Comparison between tocotrienol and omeprazole on gastric growth factors in stress-exposed rats.
Abstract AIM: To investigate and compare the effects of tocotrienol and omeprazole on gastric growth factors in rats exposed to water-immersion restraint stress (WIRS). METHODS: Twenty-eight male Wistar rats were randomly assigned to four groups of seven rats. The two control groups were administered vitamin-free palm oil (vehicle) and the two treatment groups were given omeprazole (20 mg/kg) or tocotrienol (60 mg/kg) by oral gavage. After 28 d of treatment, rats from one control group and both treated groups were subjected to WIRS one time for 3.5 h. Gastric lesions were measured and gastric tissues were obt...
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Nur Azlina MF, Qodriyah HMS, Chua KH, Kamisah Y Tags: World J Gastroenterol Source Type: research

(-)-Epigallocatechin-3-gallate enhances poly I:C-induced interferon- λ1 production and inhibits hepatitis C virus replication in hepatocytes.
CONCLUSION: Our observations provide experimental evidence that EGCG has the ability to enhance poly I:C-induced intracellular antiviral innate immunity against HCV replication in hepatocytes. PMID: 28932081 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Wang YZ, Li JL, Wang X, Zhang T, Ho WZ Tags: World J Gastroenterol Source Type: research

Effects and mechanism of adenovirus-mediated phosphatase and tension homologue deleted on chromosome ten gene on collagen deposition in rat liver fibrosis.
Abstract AIM: To evaluate the effects of phosphatase and tension homologue deleted on chromosome ten (PTEN) gene on collagen metabolism in hepatic fibrosis and the underlying mechanisms. METHODS: Rat primary hepatic stellate cells (HSCs) and human LX-2 cells were transfected with adenovirus containing cDNA constructs encoding wild-type PTEN (Ad-PTEN), PTEN mutant G129E gene (Ad-G129E), and RNA interference constructs targeting the PTEN sequence PTEN short hairpin RNA to up-regulate and down-regulate the expression of PTEN. HSCs were assayed using fluorescent microscopy, real-time polymerase chain reaction, an...
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Xie SR, An JY, Zheng LB, Huo XX, Guo J, Shih D, Zhang XL Tags: World J Gastroenterol Source Type: research

Integrating TYMS, KRAS and BRAF testing in patients with metastatic colorectal cancer.
Abstract AIM: To investigate the impact of thymidylate synthase (TYMS), KRAS and BRAF in the survival of metastatic colorectal cancer (mCRC) patients treated with chemotherapy. METHODS: Clinical data were collected retrospectively from records of consecutive patients with mCRC treated with fluoropyrimidine-based chemotherapy from 1/2005 to 1/2007. Formalin-fixed paraffin-embedded tissues were retrieved for analysis. TYMS genotypes were identified with restriction fragment analysis PCR, while KRAS and BRAF mutation status was evaluated using real-time PCR assays. TYMS gene polymorphisms of each of the 3' untra...
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Ntavatzikos A, Spathis A, Patapis P, Machairas N, Peros G, Konstantoudakis S, Leventakou D, Panayiotides IG, Karakitsos P, Koumarianou A Tags: World J Gastroenterol Source Type: research

Characterizing gastrointestinal stromal tumors and evaluating neoadjuvant imatinib by sequencing of endoscopic ultrasound-biopsies.
k R Abstract AIM: To evaluate endoscopic ultrasound (EUS)-guided biopsies for the pretreatment characterization of gastrointestinal stromal tumors (GIST) to personalize the management of patients. METHODS: All patients with lesions suspected to be GIST who were referred for EUS-sampling at a tertiary Swedish center were eligible for inclusion 2006-2015. During the observational study phase (2006-2011), routine fine-needle-aspiration (EUS-FNA) was performed. In 2012-2015, we converted to an interventional, randomized protocol with dual sampling EUS-FNA and fine-needle-biopsy-sampling (EUS-FNB) for all lesions....
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Hedenström P, Nilsson B, Demir A, Andersson C, Enlund F, Nilsson O, Sadik R Tags: World J Gastroenterol Source Type: research