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Gastrointestinal stromal tumors: A multidisciplinary challenge.
o-Delgado J Abstract Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors located in the alimentary tract. Its usual manifestation is gastrointestinal bleeding. However, small asymptomatic lesions are frequently detected as incidental finding. Characteristically, most GISTs (> 95%) are positive for the KIT protein (CD117) by IHC staining and approximately 80%-90% of GISTs carry a mutation in the c-KIT or PDGFRA genes. Mutational analysis should be performed when planning adjuvant and neoadjuvant therapy, due to its possible resistance to conventional treatment. The arise of tyrosine ki...
Source: World Journal of Gastroenterology : WJG - May 14, 2018 Category: Gastroenterology Authors: Sanchez-Hidalgo JM, Duran-Martinez M, Molero-Payan R, Rufian-Peña S, Arjona-Sanchez A, Casado-Adam A, Cosano-Alvarez A, Briceño-Delgado J Tags: World J Gastroenterol Source Type: research

New therapeutic options opened by the molecular classification of gastric cancer.
This article highlights the molecular characteristics of each subtype of gastric cancer that could be considered in shaping a therapeutic decision, and also presents the completed and ongoing clinical trials addressed to those targets. The implementation of the novel molecular classification system will allow a preliminary patient selection for clinical trials, a mandatory issue if it is desired to test the efficacy of a certain inhibitor to the given target. This will represent a substantial advance as well as a powerful tool for targeted therapy. Nevertheless, translating the scientific results into new personalized trea...
Source: World Journal of Gastroenterology : WJG - May 14, 2018 Category: Gastroenterology Authors: Chivu-Economescu M, Matei L, Necula LG, Dragu DL, Bleotu C, Diaconu CC Tags: World J Gastroenterol Source Type: research

Ambiguous roles of innate lymphoid cells in chronic development of liver diseases.
Abstract Innate lymphoid cells (ILCs) are defined as a distinct arm of innate immunity. According to their profile of secreted cytokines and lineage-specific transcriptional factors, ILCs can be categorized into the following three groups: group 1 ILCs (including natural killer (NK) cells and ILC1s) are dependent on T-bet and can produce interferon-γ; group 2 ILCs (ILC2s) are dependent on GATA3 and can produce type 2 cytokines, including interleukin (IL)-5 and IL-13; and, group 3 ILCs (including lymphoid tissue-like cells and ILC3s) are dependent on RORγt and can produce IL-22 and IL-17. Collaborative ...
Source: World Journal of Gastroenterology : WJG - May 14, 2018 Category: Gastroenterology Authors: Shen Y, Li J, Wang SQ, Jiang W Tags: World J Gastroenterol Source Type: research

Laparoscopic gastrojejunostomy for gastric outlet obstruction in patients with unresectable hepatopancreatobiliary cancers: A personal series and systematic review of the literature.
lamas R, Ramia JM Abstract The major symptoms of advanced hepatopancreatic-biliary cancer are biliary obstruction, pain and gastric outlet obstruction (GOO). For obstructive jaundice, surgical treatment should de consider in recurrent stent complications. The role of surgery for pain relief is marginal nowadays. On the last, there is no consensus for treatment of malignant GOO. Endoscopic duodenal stents are associated with shorter length of stay and faster relief to oral intake with more recurrent symptoms. Surgical gastrojejunostomy shows better long-term results and lower re-intervention rates, but there are li...
Source: World Journal of Gastroenterology : WJG - May 14, 2018 Category: Gastroenterology Authors: Manuel-Vázquez A, Latorre-Fragua R, Ramiro-Pérez C, López-Marcano A, la Plaza-Llamas R, Ramia JM Tags: World J Gastroenterol Source Type: research

Mouse models for investigating the underlying mechanisms of nonalcoholic steatohepatitis-derived hepatocellular carcinoma.
Abstract As the incidence of hepatocellular carcinoma (HCC) caused by infection with the hepatotropic viruses hepatitis B and hepatitis C decreases, greater attention has become focused on HCC caused by nonalcoholic steatohepatitis (NASH), an advanced form of nonalcoholic fatty liver disease which has shown increasing prevalence in correspondence with the overall increase in metabolic syndrome over the recent decades. Several clinical population studies have shown a positive relationship between NASH and HCC, while also providing initial insights into the underlying mechanisms of HCC development from NASH. Researc...
Source: World Journal of Gastroenterology : WJG - May 14, 2018 Category: Gastroenterology Authors: Takakura K, Oikawa T, Tomita Y, Mizuno Y, Nakano M, Saeki C, Torisu Y, Saruta M Tags: World J Gastroenterol Source Type: research

Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice.
Abstract AIM: To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer (CAC). METHODS: C57BL/6 mice received an intraperitoneal injection of azoxymethane (10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water (5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacillus rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16S rRNA Illumina HiSeq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Rea...
Source: World Journal of Gastroenterology : WJG - May 14, 2018 Category: Gastroenterology Authors: Mendes MCS, Paulino DS, Brambilla SR, Camargo JA, Persinoti GF, Carvalheira JBC Tags: World J Gastroenterol Source Type: research

Ischemia/reperfusion injury in porcine intestine - Viability assessment.
CONCLUSION: Three hours of total ischemia of the small bowel followed by reperfusion appears to be the upper limit for viability in this porcine mesenteric ischemia model. PMID: 29760544 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2018 Category: Gastroenterology Authors: Strand-Amundsen RJ, Reims HM, Reinholt FP, Ruud TE, Yang R, Høgetveit JO, Tønnessen TI Tags: World J Gastroenterol Source Type: research

Quantitative assessment of hepatic fibrosis in chronic hepatitis B and C: T1 mapping on Gd-EOB-DTPA-enhanced liver magnetic resonance imaging.
Abstract AIM: To assess the accuracy of Look-Locker on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) for staging liver fibrosis in chronic hepatitis B/C (CHB/C). METHODS: We prospectively included 109 patients with CHB or CHC who underwent a 3.0-Tesla MRI examination, including T1-weighted and Look-Locker sequences for T1 mapping. Hepatocyte fractions (HeF) and relaxation time reduction rate (RE) were measured for staging liver fibrosis. A receiver operating characteristic analysis using the area under the receiver operating characteristic ...
Source: World Journal of Gastroenterology : WJG - May 14, 2018 Category: Gastroenterology Authors: Pan S, Wang XQ, Guo QY Tags: World J Gastroenterol Source Type: research

Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn's disease.
Abstract AIM: To determine the distribution of anthropometric parameter (AP)-z-scores and characterize associations between medications/serum biomarkers and AP-z-scores in pediatric Crohn's disease (CD). METHODS: CD patients [
Source: World Journal of Gastroenterology : WJG - May 14, 2018 Category: Gastroenterology Authors: Gupta N, Lustig RH, Chao C, Vittinghoff E, Andrews H, Leu CS Tags: World J Gastroenterol Source Type: research

Is it possible to stop nucleos(t)ide analogue treatment in chronic hepatitis B patients?
Larrubia JR Abstract Chronic hepatitis B (CHB) remains a challenging global health problem, with nearly one million related deaths per year. Nucleos(t)ide analogue (NA) treatment suppresses viral replication but does not provide complete cure of the hepatitis B virus (HBV) infection. The accepted endpoint for therapy is the loss of hepatitis B surface antigen (HBsAg), but this is hardly ever achieved. Therefore, indefinite treatment is usually required. Many different studies have evaluated NA therapy discontinuation after several years of NA treatment and before HBsAg loss. The results have indicated that the maj...
Source: World Journal of Gastroenterology : WJG - May 7, 2018 Category: Gastroenterology Authors: Moreno-Cubero E, Del Arco RTS, Peña-Asensio J, de Villalobos ES, Míquel J, Larrubia JR Tags: World J Gastroenterol Source Type: research

Emergence of immunotherapy as a novel way to treat hepatocellular carcinoma.
Abstract Tumor immunity proceeds through multiple processes, which consist of antigen presentation by antigen presenting cells (APCs) to educate effector cells and destruction by the effector cytotoxic cells. However, tumor immunity is frequently repressed at tumor sites. Malignantly transformed cells rarely survive the attack by the immune system, but cells that do survive change their phenotypes to reduce their immunogenicity. The resultant cells evade the attack by the immune system and form clinically discernible tumors. Tumor microenvironments simultaneously contain a wide variety of immune suppressive molecu...
Source: World Journal of Gastroenterology : WJG - May 7, 2018 Category: Gastroenterology Authors: Mukaida N, Nakamoto Y Tags: World J Gastroenterol Source Type: research

Endoscopic management of Crohn's strictures.
Abstract Symptomatic intestinal strictures develop in more than one third of patients with Crohn's disease (CD) within 10 years of disease onset. Strictures can be inflammatory, fibrotic or mixed and result in a significant decline in quality of life, frequently requiring surgery for palliation of symptoms. Patients under the age of 40 with perianal disease are more likely to suffer from disabling ileocolonic disease thus may have a greater risk for fibrostenotic strictures. Treatment options for fibrostenotic strictures are limited to endoscopic and surgical therapy. Endoscopic balloon dilatation (EBD) appears to...
Source: World Journal of Gastroenterology : WJG - May 7, 2018 Category: Gastroenterology Authors: Bessissow T, Reinglas J, Aruljothy A, Lakatos PL, Van Assche G Tags: World J Gastroenterol Source Type: research

Anti-integrin therapy for inflammatory bowel disease.
Abstract In inflammatory bowel disease (IBD), tumor necrosis factor plays an important role in mediating inflammation, but several other pathways are also involved in eliciting an inflammatory response. One such pathway is the invasion of the intestinal mucosa by leukocytes. Leukocytes within the systemic circulation move to sites of inflammation, and blocking this pathway could be an important treatment strategy for IBD. Anti-integrin therapy blocks the action of integrin on the surface of circulating immune cells and endothelial cell adhesion molecules, thereby inhibiting the interactions between leukocytes and ...
Source: World Journal of Gastroenterology : WJG - May 7, 2018 Category: Gastroenterology Authors: Park SC, Jeen YT Tags: World J Gastroenterol Source Type: research

Olfactomedin-4 in digestive diseases: A mini-review.
Abstract Olfactomedin-4 (OLFM4, GW112, hGC-1) is a glycoprotein belonging to the olfactomedin family. The expression of OLFM4 is strong in the small intestine, colon and prostate, and moderate in the stomach and bone marrow. Previous studies have revealed that OLFM4 is closely associated with many digestive diseases. Up-regulation of OLFM4 has been detected in the Helicobacter pylori (H. pylori)-infected gastric mucosa, inflammatory bowel disease tissue and gastrointestinal malignancies, including gastric cancer, colorectal cancer, pancreatic cancer and gallbladder cancer. Down-regulation of OLFM4 has also been de...
Source: World Journal of Gastroenterology : WJG - May 7, 2018 Category: Gastroenterology Authors: Wang XY, Chen SH, Zhang YN, Xu CF Tags: World J Gastroenterol Source Type: research

Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models.
CONCLUSION: Our results suggest that activation of GC-C signaling might be involved in maintenance of barrier function, possibly through regulating normal localization of tight junction proteins. Consistent with these findings, plecanatide and dolcanatide showed potent anti-nociceptive activity in rat visceral hypersensitivity models. These results imply that activation of GC-C signaling may be an attractive therapeutic approach to treat functional constipation disorders and inflammatory gastrointestinal conditions. PMID: 29740204 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2018 Category: Gastroenterology Authors: Boulete IM, Thadi A, Beaufrand C, Patwa V, Joshi A, Foss JA, Eddy EP, Eutamene H, Palejwala VA, Theodorou V, Shailubhai K Tags: World J Gastroenterol Source Type: research

Mitochondrial pathway mediated by reactive oxygen species involvement in α-hederin-induced apoptosis in hepatocellular carcinoma cells.
Mitochondrial pathway mediated by reactive oxygen species involvement in α-hederin-induced apoptosis in hepatocellular carcinoma cells. World J Gastroenterol. 2018 May 07;24(17):1901-1910 Authors: Li J, Wu DD, Zhang JX, Wang J, Ma JJ, Hu X, Dong WG Abstract AIM: To investigate the antitumor activity of α-hederin in hepatocellular carcinoma (HCC) cells and its underlying mechanisms in vitro and in vivo. METHODS: SMMC-7721, HepG-2 and Huh-7 HCC cells were cultured in vitro and treated with α-hederin (0, 5 μmol/L, 10 μmol/L, 15 μmol/L, 20 μmol/L, 25 μmol/L, 30 μmo...
Source: World Journal of Gastroenterology : WJG - May 7, 2018 Category: Gastroenterology Authors: Li J, Wu DD, Zhang JX, Wang J, Ma JJ, Hu X, Dong WG Tags: World J Gastroenterol Source Type: research

Usefulness of three-dimensional visualization technology in minimally invasive treatment for infected necrotizing pancreatitis.
CONCLUSION: The 3D visualization technology could optimize the PCD puncture paths, improving the drainage effect in patients with INP. Moreover, it significantly increased the efficiency of necrosectomy through the rigid nephroscope. As a result, it decreased operation times and improved the prognosis. PMID: 29740206 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2018 Category: Gastroenterology Authors: Wang PF, Liu ZW, Cai SW, Su JJ, He L, Feng J, Xin XL, Lu SC Tags: World J Gastroenterol Source Type: research

Development of tenofovir disoproxil fumarate resistance after complete viral suppression in a patient with treatment-na ïve chronic hepatitis B: A case report and review of the literature.
Development of tenofovir disoproxil fumarate resistance after complete viral suppression in a patient with treatment-naïve chronic hepatitis B: A case report and review of the literature. World J Gastroenterol. 2018 May 07;24(17):1919-1924 Authors: Cho WH, Lee HJ, Bang KB, Kim SB, Song IH Abstract Tenofovir disoproxil fumarate (TDF) is a potent nucleotide analogue that is recommended as first-line therapy for patients with chronic hepatitis B. The results of a longitudinal study of TDF treatment demonstrated no development of resistance. We observed one treatment-naïve chronic hepatitis B (C...
Source: World Journal of Gastroenterology : WJG - May 7, 2018 Category: Gastroenterology Authors: Cho WH, Lee HJ, Bang KB, Kim SB, Song IH Tags: World J Gastroenterol Source Type: research

Beneficial effects of naringenin in liver diseases: Molecular mechanisms.
iel P Abstract Liver diseases are caused by different etiological agents, mainly alcohol consumption, viruses, drug intoxication or malnutrition. Frequently, liver diseases are initiated by oxidative stress and inflammation that lead to the excessive production of extracellular matrix (ECM), followed by a progression to fibrosis, cirrhosis and hepatocellular carcinoma (HCC). It has been reported that some natural products display hepatoprotective properties. Naringenin is a flavonoid with antioxidant, antifibrogenic, anti-inflammatory and anticancer properties that is capable of preventing liver damage caused by d...
Source: World Journal of Gastroenterology : WJG - April 28, 2018 Category: Gastroenterology Authors: Hernández-Aquino E, Muriel P Tags: World J Gastroenterol Source Type: research

Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression.
In conclusion, the presence of baseline RT mutations can affect drug treatment outcomes and disease progression in HBV-infected populations via modulation of viral fitness and host-immune responses. PMID: 29713126 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2018 Category: Gastroenterology Authors: Choi YM, Lee SY, Kim BJ Tags: World J Gastroenterol Source Type: research

Nucleotide-binding oligomerization domain 1 and Helicobacter pylori infection: A review.
Abstract Nucleotide-binding oligomerization domain 1 (NOD1) is an intracellular innate immune sensor for small molecules derived from bacterial cell components. NOD1 activation by its ligands leads to robust production of pro-inflammatory cytokines and chemokines by innate immune cells, thereby mediating mucosal host defense systems against microbes. Chronic gastric infection due to Helicobacter pylori (H. pylori) causes various upper gastrointestinal diseases, including atrophic gastritis, peptic ulcers, and gastric cancer. It is now generally accepted that detection of H. pylori by NOD1 expressed in gastric epit...
Source: World Journal of Gastroenterology : WJG - April 28, 2018 Category: Gastroenterology Authors: Minaga K, Watanabe T, Kamata K, Asano N, Kudo M Tags: World J Gastroenterol Source Type: research

Diversion colitis and pouchitis: A mini-review.
Abstract Diversion colitis is characterized by inflammation of the mucosa in the defunctioned segment of the colon after colostomy or ileostomy. Similar to diversion colitis, diversion pouchitis is an inflammatory disorder occurring in the ileal pouch, resulting from the exclusion of the fecal stream and a subsequent lack of nutrients from luminal bacteria. Although the vast majority of patients with surgically-diverted gastrointestinal tracts remain asymptomatic, it has been reported that diversion colitis and pouchitis might occur in almost all patients with diversion. Surgical closure of the stoma, with reest...
Source: World Journal of Gastroenterology : WJG - April 28, 2018 Category: Gastroenterology Authors: Tominaga K, Kamimura K, Takahashi K, Yokoyama J, Yamagiwa S, Terai S Tags: World J Gastroenterol Source Type: research

Nonalcoholic steatohepatitis severity is defined by a failure in compensatory antioxidant capacity in the setting of mitochondrial dysfunction.
CONCLUSION: Oxidative stress, and/or the capacity to compensate for increased oxidative stress, in the setting of mitochondrial dysfunction, is a key factor for development of hepatic injury and fibrosis in these mouse models. PMID: 29713129 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2018 Category: Gastroenterology Authors: Boland ML, Oldham S, Boland BB, Will S, Lapointe JM, Guionaud S, Rhodes CJ, Trevaskis JL Tags: World J Gastroenterol Source Type: research

Mucosa repair mechanisms of Tong-Xie-Yao-Fang mediated by CRH-R2 in murine, dextran sulfate sodium-induced colitis.
Abstract AIM: To explore the significance of corticotropin-releasing hormone (CRH)-receptor (R)2 in mucosal healing of dextran sulfate sodium (DSS)-induced colitis and the effect of Tong-Xie-Yao-Fang (TXYF) on CRH-R2 expression and regulation. METHODS: Ulcerative colitis was induced in mice by administration of 3% (w/v) DSS for 7 d. Once the model was established, mice were administered urocortin-2 (30 μg/kg), a peptide which binds exclusively to CRH-R2, or various doses of aqueous TXYF extracts (2.8-11.2 g/kg), a CRH-R2 antagonist Astressin (Ast)2B (20 μg/kg), Ast2B + Ucn2, or Ast2B with various doses ...
Source: World Journal of Gastroenterology : WJG - April 28, 2018 Category: Gastroenterology Authors: Gong SS, Fan YH, Wang SY, Han QQ, Lv B, Xu Y, Chen X, He YE Tags: World J Gastroenterol Source Type: research

Sodium chloride exacerbates dextran sulfate sodium-induced colitis by tuning proinflammatory and antiinflammatory lamina propria mononuclear cells through p38/MAPK pathway in mice.
CONCLUSION: Proinflammatory macrophages may play an essential role in the onset and development of NaCl-promoted inflammation in DSS-induced colitis. The underlining mechanism involves up-regulation of the p38/MAPK axis. PMID: 29713131 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2018 Category: Gastroenterology Authors: Guo HX, Ye N, Yan P, Qiu MY, Zhang J, Shen ZG, He HY, Tian ZQ, Li HL, Li JT Tags: World J Gastroenterol Source Type: research

High tacrolimus intra-patient variability is associated with graft rejection, and de novo donor-specific antibodies occurrence after liver transplantation.
CONCLUSION: Tacrolimus-IPV could be a useful tool to identify patients with a greater risk of graft rejection and of developing a de novo DSA after liver transplantation. PMID: 29713132 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2018 Category: Gastroenterology Authors: Del Bello A, Congy-Jolivet N, Danjoux M, Muscari F, Lavayssière L, Esposito L, Hebral AL, Bellière J, Kamar N Tags: World J Gastroenterol Source Type: research

Papillary fistulotomy vs conventional cannulation for endoscopic biliary access: A prospective randomized trial.
CONCLUSION: Papillary fistulotomy was more effective than guidewire cannulation, and it was associated with a lower profile of amylase and lipase. Complications were similar in both groups. PMID: 29713133 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2018 Category: Gastroenterology Authors: Furuya CK, Sakai P, Marinho FRT, Otoch JP, Cheng S, Prudencio LL, de Moura EGH, Artifon ELA Tags: World J Gastroenterol Source Type: research

Compared efficacy of preservation solutions on the outcome of liver transplantation: Meta-analysis.
CONCLUSION: Alternative solutions for UW yield the same degree of safety and effectiveness for the preservation of DDLs, but further well-designed clinical trials are warranted. PMID: 29713134 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2018 Category: Gastroenterology Authors: Szilágyi ÁL, Mátrai P, Hegyi P, Tuboly E, Pécz D, Garami A, Solymár M, Pétervári E, Balaskó M, Veres G, Czopf L, Wobbe B, Szabó D, Wagner J, Hartmann P Tags: World J Gastroenterol Source Type: research

Ultrasound findings in autoimmune hepatitis.
Abstract Ultrasound findings in autoimmune hepatitis (AIH) have not been reported systematically so far. The use of reliable and accurate noninvasive methods for determining fibrosis stage is important in evaluation of treatment efficacy and fibrosis regression in AIH. Imaging plays an important role in detection of complications and ruling out other possible causes of chronic liver diseases. Ultrasound elastography cut-off values in AIH patients are not the same as those in patients with chronic viral hepatitis or non-alcoholic fatty liver disease. AIH is characterized by wide fluctuations in inflammatory activit...
Source: World Journal of Gastroenterology : WJG - April 21, 2018 Category: Gastroenterology Authors: Dong Y, Potthoff A, Klinger C, Barreiros AP, Pietrawski D, Dietrich CF Tags: World J Gastroenterol Source Type: research

Nutrition status and Helicobacter pylori infection in patients receiving hemodialysis.
Abstract Chronic kidney disease (CKD) patients receiving hemodialysis (HD) often develop gastrointestinal abnormalities over their long treatment period. In general, prognosis in such patients is poor due to the development of protein-energy wasting (PEW). Therefore, it is important to clarify the etiology of PEW and to establish better strategies to deal with this condition. Chronic Helicobacter pylori (H. pylori) infection in the gastric mucosa has a close association with not only the development of peptic ulcer disease and gastric cancer, but is also associated with abnormal plasma and gastric mucosal ghrelin ...
Source: World Journal of Gastroenterology : WJG - April 21, 2018 Category: Gastroenterology Authors: Sugimoto M, Yasuda H, Andoh A Tags: World J Gastroenterol Source Type: research

Multiomics biomarkers for the prediction of nonalcoholic fatty liver disease severity.
Abstract This review intends to uncover how information from large-scale genetic profiling (whole genome sequencing, and whole exome sequencing) of nonalcoholic fatty liver disease (NAFLD), as well as information from circulating transcriptomics (cell-free miRNAs) and metabolomics, contributes to the understanding of NAFLD pathogenesis. A further aim is to address the question of whether OMICs information is ready to be implemented in the clinics. The available evidence suggests that any new knowledge pertaining to molecular signatures associated with NAFLD and nonalcoholic steatohepatitis should be promptly trans...
Source: World Journal of Gastroenterology : WJG - April 21, 2018 Category: Gastroenterology Authors: Pirola CJ, Sookoian S Tags: World J Gastroenterol Source Type: research

Autonomic nervous system network and liver regeneration.
Abstract To date, various signal transducers, cytokines, growth factors, and hormones have been reported to play an important role in homeostasis of various organs. Various cells and organs are involved in the hepatic regeneration process, which proceeds as a result of the coordination of many factors. While these factors are well known to be involved in the liver regeneration after the liver injury, however, as the details of such mechanisms have not been sufficiently elucidated, the practical applicability of hepatic regeneration based on the action of these and cytokines growth factors is still unclear. In term...
Source: World Journal of Gastroenterology : WJG - April 21, 2018 Category: Gastroenterology Authors: Kamimura K, Inoue R, Nagoya T, Sakai N, Goto R, Ko M, Niwa Y, Terai S Tags: World J Gastroenterol Source Type: research

Evaluation of safety for hepatectomy in a novel mouse model with nonalcoholic-steatohepatitis.
Abstract AIM: To investigate whether the liver resection volume in a newly developed nonalcoholic steatohepatitis (NASH) model influences surgical outcome. METHODS: For establishment of a NASH model, mice were fed a high-fat diet for 4 wk, administered CCl4 for the last 2 wk, and administered T0901317 for the last 5 d. We divided these mice into two groups: A 30% partial hepatectomy (PH) of NASH liver group and a 70% PH of NASH liver group. In addition, a 70% PH of normal liver group served as the control. Each group was evaluated for survival rate, regeneration, apoptosis, necrosis and DNA expression after P...
Source: World Journal of Gastroenterology : WJG - April 21, 2018 Category: Gastroenterology Authors: Ozawa Y, Tamura T, Owada Y, Shimizu Y, Kemmochi A, Hisakura K, Matsuzaka T, Shimano H, Isoda H, Ohkohchi N Tags: World J Gastroenterol Source Type: research

Endoscopic submucosal dissection for early esophageal neoplasms using the stag beetle knife.
CONCLUSION: ESD procedures using the SB knife are feasible, safe, and effective for treating early esophageal neoplasms, yielding favorable short- and long-term outcomes. PMID: 29686470 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2018 Category: Gastroenterology Authors: Kuwai T, Yamaguchi T, Imagawa H, Miura R, Sumida Y, Takasago T, Miyasako Y, Nishimura T, Iio S, Yamaguchi A, Kouno H, Kohno H, Ishaq S Tags: World J Gastroenterol Source Type: research

Analysis of aggressiveness factors in hepatocellular carcinoma patients undergoing transarterial chemoembolization.
Abstract AIM: To investigate novel predictors of survival in hepatocellular carcinoma (HCC) patients following transarterial chemoembolization (TACE). METHODS: One hundred sixty seven patients with un-resectable HCC were retrospectively analyzed to identify factors that might contribute to their HCC biology and aggressiveness. We correlated routine laboratory results (total bilirubin, AST, ALKP, GGTP, albumin etc.) to maximum tumor diameter, number of tumor nodules, portal vein thrombosis and blood alpha-fetoprotein levels. These 4 parameters were previously combined to form an aggressiveness index (AgI). We ...
Source: World Journal of Gastroenterology : WJG - April 21, 2018 Category: Gastroenterology Authors: Ventura Y, Carr BI, Kori I, Guerra V, Shibolet O Tags: World J Gastroenterol Source Type: research

Development and predictive validity of the cirrhosis-associated ascites symptom scale: A cohort study of 103 patients.
Abstract AIM: To develop a scale of domains associated with the health-related quality-of-life (HRQOL) in patients with cirrhosis-related ascites. METHODS: We initially undertook literature searches and a qualitative study in order to design a cirrhosis-associated ascites symptom (CAS) scale describing symptoms with a potential detrimental impact on health related quality of life (HRQL) (the higher the score, the worse the symptoms). Discriminatory validity was assessed in a validation cohort including cirrhotic patients with (1) tense/severe; (2) moderate/mild; or (3) no ascites (controls). Patients also com...
Source: World Journal of Gastroenterology : WJG - April 21, 2018 Category: Gastroenterology Authors: Riedel AN, Kimer N, Jensen AH, Dahl EK, Israelsen M, Aamann L, Gluud LL Tags: World J Gastroenterol Source Type: research

Platelet-to-lymphocyte ratio in the setting of liver transplantation for hepatocellular cancer: A systematic review and meta-analysis.
Abstract AIM: To perform a systematic review and meta-analysis on platelet-to-lymphocyte ratio (PLR) as a risk factor for post-transplant hepatocellular cancer (HCC) recurrence. METHODS: A systematic literature search was performed using PubMed. Participants of any age and sex, who underwent liver transplantation for HCC were considered following these criteria: (1) studies comparing pre-transplant low vs high PLR values; (2) studies reporting post-transplant recurrence rates; and (3) if more than one study was reported by the same institute, only the most recent was included. The primary outcome measure was ...
Source: World Journal of Gastroenterology : WJG - April 21, 2018 Category: Gastroenterology Authors: Lai Q, Melandro F, Larghi Laureiro Z, Giovanardi F, Ginanni Corradini S, Ferri F, Hassan R, Rossi M, Mennini G Tags: World J Gastroenterol Source Type: research

Impact of enhanced recovery after surgery programs on pancreatic surgery: A meta-analysis.
This study included the ERAS group (n = 1886) and the control group (n = 1808), which adopted the traditional perioperative management. Compared to the control group, the ERAS group had lower delayed gastric emptying rates [odds ratio (OR) = 0.58, 95% confidence interval (CI): 0.48-0.72, P
Source: World Journal of Gastroenterology : WJG - April 21, 2018 Category: Gastroenterology Authors: Ji HB, Zhu WT, Wei Q, Wang XX, Wang HB, Chen QP Tags: World J Gastroenterol Source Type: research

Nonalcoholic fatty liver disease and liver transplantation - Where do we stand?
Abstract Nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH) is a challenging and multisystem disease that has a high socioeconomic impact. NAFLD/NASH is a main cause of macrovesicular steatosis and has multiple impacts on liver transplantation (LT), on patients on the waiting list for transplant, on post-transplant setting as well as on organ donors. Current data indicate new trends in the area of chronic liver disease. Due to the increased incidence of metabolic syndrome (MetS) and its components, NASH cirrhosis and hepatocellular carcinoma caused by NASH will soon become a major indicatio...
Source: World Journal of Gastroenterology : WJG - April 14, 2018 Category: Gastroenterology Authors: Mikolasevic I, Filipec-Kanizaj T, Mijic M, Jakopcic I, Milic S, Hrstic I, Sobocan N, Stimac D, Burra P Tags: World J Gastroenterol Source Type: research

Hepatitis B virus pre-S/S variants in liver diseases.
Abstract Chronic hepatitis B is a global health problem. The clinical outcomes of chronic hepatitis B infection include asymptomatic carrier state, chronic hepatitis (CH), liver cirrhosis (LC), and hepatocellular carcinoma (HCC). Because of the spontaneous error rate inherent to viral reverse transcriptase, the hepatitis B virus (HBV) genome evolves during the course of infection under the antiviral pressure of host immunity. The clinical significance of pre-S/S variants has become increasingly recognized in patients with chronic HBV infection. Pre-S/S variants are often identified in hepatitis B carriers with CH,...
Source: World Journal of Gastroenterology : WJG - April 14, 2018 Category: Gastroenterology Authors: Chen BF Tags: World J Gastroenterol Source Type: research

Extra-intestinal manifestations of non-celiac gluten sensitivity: An expanding paradigm.
In conclusion, the novelty of this matter has generated an expansion of literature data with the unavoidable consequence that some reports are often based on low levels of evidence. Therefore, only studies performed on large samples with the inclusion of control groups will be able to clearly establish whether the large information from the literature regarding extra-intestinal NCGS manifestations could be supported by evidence-based agreements. PMID: 29662290 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 14, 2018 Category: Gastroenterology Authors: Losurdo G, Principi M, Iannone A, Amoruso A, Ierardi E, Di Leo A, Barone M Tags: World J Gastroenterol Source Type: research

Punctual mutations in 23S rRNA gene of clarithromycin-resistant Helicobacter pylori in Colombian populations.
CONCLUSION: The therapeutic failure of eradication treatment in the two populations from Colombia was associated with mutations of the 23S rRNA gene in clarithromycin-resistant H. pylori. PMID: 29662291 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 14, 2018 Category: Gastroenterology Authors: Matta AJ, Zambrano DC, Pazos AJ Tags: World J Gastroenterol Source Type: research

Post-polypectomy bleeding and thromboembolism risks associated with warfarin vs direct oral anticoagulants.
Abstract AIM: To verify the validity of the endoscopy guidelines for patients taking warfarin or direct oral anticoagulants (DOAC). METHODS: We collected data from 218 patients receiving oral anticoagulants (73 DOAC users, 145 warfarin users) and 218 patients not receiving any antithrombotics (age- and sex-matched controls) who underwent polypectomy. (1) We evaluated post-polypectomy bleeding (PPB) risk in patients receiving warfarin or DOAC compared with controls; (2) we assessed the risks of PPB and thromboembolism between three AC management methods: Discontinuing AC with heparin bridge (HPB) (endoscopy gu...
Source: World Journal of Gastroenterology : WJG - April 14, 2018 Category: Gastroenterology Authors: Yanagisawa N, Nagata N, Watanabe K, Iida T, Hamada M, Kobayashi S, Shimbo T, Akiyama J, Uemura N Tags: World J Gastroenterol Source Type: research

Maintenance for healed erosive esophagitis: Phase III comparison of vonoprazan with lansoprazole.
Abstract AIM: To compare vonoprazan 10 and 20 mg vs lansoprazole 15 mg as maintenance therapy in healed erosive esophagitis (EE). METHODS: A total of 607 patients aged ≥ 20 years, with endoscopically-confirmed healed EE following 8 wk of treatment with vonoprazan 20 mg once daily, were randomized 1:1:1 to receive lansoprazole 15 mg (n = 201), vonoprazan 10 mg (n = 202), or vonoprazan 20 mg (n = 204), once daily. The primary endpoint of the study was the rate of endoscopically-confirmed EE recurrence during a 24-wk maintenance period. The secondary endpoint was the EE recurrence rate at Week 12 during maint...
Source: World Journal of Gastroenterology : WJG - April 14, 2018 Category: Gastroenterology Authors: Ashida K, Iwakiri K, Hiramatsu N, Sakurai Y, Hori T, Kudou K, Nishimura A, Umegaki E Tags: World J Gastroenterol Source Type: research

Application of enhanced recovery after gastric cancer surgery: An updated meta-analysis.
Abstract AIM: To provide an updated assessment of the safety and efficacy of enhanced recovery after surgery (ERAS) protocols in elective gastric cancer (GC) surgery. METHODS: PubMed, Medline, EMBASE, World Health Organization International Trial Register, and Cochrane Library were searched up to June 2017 for all available randomized controlled trials (RCTs) comparing ERAS protocols and standard care (SC) in GC surgery. Thirteen RCTs, with a total of 1092 participants, were analyzed in this study, of whom 545 underwent ERAS protocols and 547 received SC treatment. RESULTS: No significant difference was ...
Source: World Journal of Gastroenterology : WJG - April 14, 2018 Category: Gastroenterology Authors: Wang LH, Zhu RF, Gao C, Wang SL, Shen LZ Tags: World J Gastroenterol Source Type: research

Should hot biopsy forceps be abandoned for polypectomy of diminutive colorectal polyps?
This article discusses the usefulness and contemporary practical applicability of hot biopsy forceps and provides well-intentioned criticism of the new European guidelines for the treatment of DCPs. Diminutive colorectal polyps are a source of frustration for the endoscopist since their small size is accompanied by a considerable risk of premalignant neoplasia and a small but non-negligible risk of advanced neoplasia and even cancer. Since the proportion of diminutive colorectal polyps is substantial and exceeds that of larger polyps, their effective removal poses a considerable workload and a therapeutic challenge. During...
Source: World Journal of Gastroenterology : WJG - April 14, 2018 Category: Gastroenterology Authors: Panteris V, Vezakis A, Triantafillidis JK Tags: World J Gastroenterol Source Type: research

Review article: Update on current and emergent data on hepatopulmonary syndrome.
Abstract Hepatopulmonary syndrome (HPS) is a frequent pulmonary complication of end-stage liver disease, characterized by impaired arterial oxygenation induced by intrapulmonary vascular dilatation. Its prevalence ranges from 4% to 47% in patients with cirrhosis due to the different diagnostic criteria applied among different studies. Nitric oxide overproduction and angiogenesis seem to be the hallmarks of a complicated pathogenetic mechanism, leading to intrapulmonary shunting and ventilation-perfusion mismatch. A classification of HPS according to the severity of hypoxemia has been suggested. Contrast-enhanced e...
Source: World Journal of Gastroenterology : WJG - March 28, 2018 Category: Gastroenterology Authors: Soulaidopoulos S, Cholongitas E, Giannakoulas G, Vlachou M, Goulis I Tags: World J Gastroenterol Source Type: research

Cell culture-adaptive mutations in hepatitis C virus promote viral production by enhancing viral replication and release.
CONCLUSION: In this study, we generated infectious HCV particles with a robust titer of 1.61 × 106 FFUs/mL, and found that the viral replication and release levels could be enhanced by some of the adaptive mutations. PMID: 29599605 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 28, 2018 Category: Gastroenterology Authors: Wang Q, Li Y, Liu SA, Xie W, Cheng J Tags: World J Gastroenterol Source Type: research

Serum interleukin-34 level can be an indicator of liver fibrosis in patients with chronic hepatitis B virus infection.
CONCLUSION: Our results indicate that IL-34, a cytokine involved in the induction of activation of profibrogenic macrophages, can be an indicator of liver inflammation and fibrosis in patients with chronic HBV infection. PMID: 29599606 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 28, 2018 Category: Gastroenterology Authors: Wang YQ, Cao WJ, Gao YF, Ye J, Zou GZ Tags: World J Gastroenterol Source Type: research

Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models.
CONCLUSION: BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter (S-LAD). PMID: 29599607 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 28, 2018 Category: Gastroenterology Authors: Wongjarupong N, Negron-Ocasio GM, Chaiteerakij R, Addissie BD, Mohamed EA, Mara KC, Harmsen WS, Theobald JP, Peters BE, Balsanek JG, Ward MM, Giama NH, Venkatesh SK, Harnois DM, Charlton MR, Yamada H, Algeciras-Schimnich A, Snyder MR, Therneau TM, Roberts Tags: World J Gastroenterol Source Type: research