Progress in elucidating the relationship between < em > Helicobacter pylori < /em > infection and intestinal diseases
World J Gastroenterol. 2021 Dec 21;27(47):8040-8046. doi: 10.3748/wjg.v27.i47.8040.ABSTRACTHelicobacter pylori (H. pylori) infection causes changes to the intestinal flora, such as small intestinal bacterial overgrowth, and increases gastric acid secretion-stimulating gastrointestinal hormones, mainly gastrin, due to a decrease in gastric acid caused by atrophic gastritis. In addition, the cellular components of H. pylori travel through the intestinal tract, so the bacterial infection affects the immune system. Therefore, the effects of H. pylori infection are observed not only in the stomach and the proximal duodenum but ...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Shunji Fujimori Source Type: research

Orphan patients with inflammatory bowel disease - when we treat beyond evidence
World J Gastroenterol. 2021 Dec 21;27(47):8047-8057. doi: 10.3748/wjg.v27.i47.8047.ABSTRACTInflammatory bowel disease (IBD) is a chronic condition that requires continuous medical treatment. To date, the medical management of patients with moderately-to-severely active IBD who develop dependence or resistance to corticosteroids is based on immunomodulator drugs. Such therapies are licenced after passing through three phases of randomized controlled trials (RCTs), and are subsequently adopted in clinical practice. However, the real-life population of IBD patients who require these therapies can significantly differ from tho...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Giuseppe Privitera Daniela Pugliese Loris Riccardo Lopetuso Franco Scaldaferri Alfredo Papa Gian Lodovico Rapaccini Antonio Gasbarrini Alessandro Armuzzi Source Type: research

Analogies between medusa and single port surgery in gastroenterology and hepatology: A review
World J Gastroenterol. 2021 Dec 21;27(47):8058-8068. doi: 10.3748/wjg.v27.i47.8058.ABSTRACTSingle port surgery (SPS) was introduced as an attractive, minimally invasive surgical technique that ensures esthetic results for many types of visceral surgery. Initially, surgeons immediately set about performing SPS without preliminary knowledge or training, which resulted in higher complication rates. Today, current studies conclusively show that SPS is scientifically rehabilitated and indicated for simple and complex laparoscopic procedures. We here describe the astonishing analogies between Greek mythology and modern surgery.P...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Christof Mittermair Helmut G Weiss Source Type: research

Chinese expert consensus on neoadjuvant and conversion therapies for hepatocellular carcinoma
World J Gastroenterol. 2021 Dec 21;27(47):8069-8080. doi: 10.3748/wjg.v27.i47.8069.ABSTRACTThe low resection and high recurrence rates in hepatocellular carcinoma (HCC) are the major challenges to improving prognosis. Neoadjuvant and conversion therapies are underlying strategies to overcome these challenges. To date, no guideline or consensus has been published on the neoadjuvant and conversion therapies in HCC. Recent studies showed that neoadjuvant therapy for resectable HCC and conversion therapy for unresectable HCC are safe, feasible, and effective. Neoadjuvant and conversion therapies have the following advantages i...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Hai-Tao Zhao Jian-Qiang Cai Source Type: research

Present and future management of viral hepatitis
World J Gastroenterol. 2021 Dec 21;27(47):8081-8102. doi: 10.3748/wjg.v27.i47.8081.ABSTRACTViral hepatitis can result in important morbidity and mortality, with its impact on health conditioned by the specific type of hepatitis, the geographical region of presentation and the development and access to new drugs, among other factors. Most acute presentation forms are self-limiting and may even go unnoticed, with just a small percentage of cases leading to acute liver failure that may necessitate transplantation or even cause the death of the patient. However, when they become chronic, as in the case of hepatitis B virus and...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Roc ío González Grande Inmaculada Santaella Leiva Susana L ópez Ortega Miguel Jim énez Pérez Source Type: research

Artificial intelligence-assisted colonoscopy: A review of current state of practice and research
This article takes a closer look at the current state of AI integration into the field of colonoscopy and offers suggestions for future research.PMID:35068857 | PMC:PMC8704267 | DOI:10.3748/wjg.v27.i47.8103 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Mahsa Taghiakbari Yuichi Mori Daniel von Renteln Source Type: research

Immunotherapies for well-differentiated grade 3 gastroenteropancreatic neuroendocrine tumors: A new category in the World Health Organization classification
World J Gastroenterol. 2021 Dec 21;27(47):8123-8137. doi: 10.3748/wjg.v27.i47.8123.ABSTRACTAccording to the 2019 World Health Organization (WHO) classification, well-differentiated grade 3 (G3) gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) are a new category of cancer of the digestive system. G3 GEP-NET research and treatment are not as robust as those of lower grade (G1/2) NETs and poorly differentiated neuroendocrine carcinomas (NECs). Previously, the management of high-grade NETs was mainly based on NEC therapies, as high-grade NETs were classified as NECs under the previous WHO classification. Despite this,...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Jun-Xi Xu De-Hao Wu Li-Wei Ying Han-Guang Hu Source Type: research

Impact of intrarectal chromofungin treatment on dendritic cells-related markers in different immune compartments in colonic inflammatory conditions
CONCLUSION: CHR has protective properties against intestinal inflammation via the regulation of DC-related markers and CD11c+ cells. CHR could be a potential therapy of UC.PMID:35068859 | PMC:PMC8704268 | DOI:10.3748/wjg.v27.i47.8138 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Kunal Kapoor Nour Eissa Diane Tshikudi Charles N Bernstein Jean-Eric Ghia Source Type: research

Multiparameter magnetic resonance imaging of liver fibrosis in a bile duct ligation mouse model
World J Gastroenterol. 2021 Dec 21;27(47):8156-8165. doi: 10.3748/wjg.v27.i47.8156.ABSTRACTBACKGROUND: Bile duct ligation (BDL) in animals is a classical method for mimicking cholestatic fibrosis. Although different surgical techniques have been described in rats and rabbits, mouse models can be more cost-effective and reproducible for investigating cholestatic fibrosis. Magnetic resonance imaging (MRI) has made great advances for noninvasive assessment of liver fibrosis. More comprehensive liver fibrotic features of BDL on MRI are important. However, the utility of multiparameter MRI to detect liver fibrosis in a BDL mous...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Jia-Yi Liu Zhu-Yuan Ding Zi-Yi Zhou Sheng-Zhen Dai Jie Zhang Hao Li Qiu Du Ye-Yu Cai Quan-Liang Shang Yong-Heng Luo En-Hua Xiao Source Type: research

Disease control and failure patterns of unresectable hepatocellular carcinoma following transarterial radioembolization with yttrium-90 microspheres and with/without sorafenib
World J Gastroenterol. 2021 Dec 21;27(47):8166-8181. doi: 10.3748/wjg.v27.i47.8166.ABSTRACTBACKGROUND: Impressive survival outcome of our previous study in unresectable hepatocellular carcinoma (HCC) patients undergoing yttrium-90 glass microspheres transarterial radioembolization (TARE) with/without sorafenib according to individuals' disease burden, i.e., intrahepatic tumor load (IHT) and adverse disease features (ADFs) might partly be confounded by other treatments and underlying hepatic function. Therefore, a dedicated study focusing on treatment response and assessment of failure patterns might be a way to improve tre...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Ajalaya Teyateeti Armeen Mahvash James Long Mohamed Abdelsalam Rony Avritscher Ahmed Kaseb Bruno Odisio Gregory Ravizzini Devaki Surasi Achiraya Teyateeti Homer Macapinlac Srinivas Cheenu Kappadath Source Type: research

Real-world local recurrence rate after cold polypectomy in colorectal polyps less than 10 mm using propensity score matching
CONCLUSION: Local recurrence after CP was equivalent to that following HP in clinical practice. CP is useful and safe in the treatment of non-pedunculated polyps of less than 10 mm.PMID:35068862 | PMC:PMC8704276 | DOI:10.3748/wjg.v27.i47.8182 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Masashi Saito Takeshi Yamamura Masanao Nakamura Keiko Maeda Tsunaki Sawada Eri Ishikawa Yasuyuki Mizutani Takuya Ishikawa Naomi Kakushima Kazuhiro Furukawa Eizaburo Ohno Hiroki Kawashima Masatoshi Ishigami Mitsuhiro Fujishiro Source Type: research

Microarray analysis to explore the effect of < em > CXCL12 < /em > isoforms in a pancreatic pre-tumor cell model
World J Gastroenterol. 2021 Dec 21;27(47):8194-8198. doi: 10.3748/wjg.v27.i47.8194.ABSTRACTCXCL12 expression was significantly lower in tumor samples than in corresponding normal samples. CXCL12 expression was significantly positively related to the infiltration levels of T cells, dendritic cells (DCs), immature DCs, cytotoxic cells, Tfh cells, mast cells, B cells, Th1 cells, natural killer (NK) cells, pDCs, neutrophils, and T helper cells (Spearman correlation coefficient> 0.5, P
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Yan-Dong Miao Jiang-Tao Wang Xiao-Long Tang Deng-Hai Mi Source Type: research

Progress on global hepatitis elimination targets
World J Gastroenterol. 2021 Dec 21;27(47):8199-8200. doi: 10.3748/wjg.v27.i47.8199.ABSTRACTIn 2016, the World Health Assembly adopted a Global Health Sector Strategy on viral hepatitis, with targets set for the years 2020 and 2030 to achieve hepatitis elimination. The main target of hepatitis elimination strategy is to reduce the incidence of hepatitis B virus (HBV) and hepatitis C virus (HCV) by 90% and mortality by 65% in 2030. In last 5 years, the number of people receiving HCV treatment has increased from 1 million to 9.4 million; however, this number is far from the 2030 target of 40 million people receiving HCV treat...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Yasir Waheed Source Type: research

Palmitoylation in Crohn's disease: Current status and future directions
World J Gastroenterol. 2021 Dec 28;27(48):8201-8215. doi: 10.3748/wjg.v27.i48.8201.ABSTRACTS-palmitoylation is one of the most common post-translational modifications in nature; however, its importance has been overlooked for decades. Crohn's disease (CD), a subtype of inflammatory bowel disease (IBD), is an autoimmune disease characterized by chronic inflammation involving the entire gastrointestinal tract. Bowel damage and subsequent disabilities caused by CD are a growing global health issue. Well-acknowledged risk factors for CD include genetic susceptibility, environmental factors, such as a westernized lifestyle, and...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Wei-Xin Cheng Yue Ren Miao-Miao Lu Ling-Ling Xu Jian-Guo Gao Dong Chen Farhin Shaheed Kalyani Zi-Yan Lv Chun-Xiao Chen Feng Ji He-Ning Lin Xi Jin Source Type: research

New era of electrochemotherapy in treatment of liver tumors in conjunction with immunotherapies
World J Gastroenterol. 2021 Dec 28;27(48):8216-8226. doi: 10.3748/wjg.v27.i48.8216.ABSTRACTElectrochemotherapy is a local ablative therapy that increases the cytotoxicity of either bleomycin or cisplatin by applying electric pulses (electroporation) to tumors. It has already been widely used throughout Europe for the treatment of various types of human and veterinary cutaneous tumors, with an objective response rate ranging from 70%-90%, depending on the tumor histotype. Recently, electrochemotherapy was introduced for the treatment of primary liver tumors, such as hepatocellular carcinoma (HCC). The complete response rate...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Bla ž Trotovšek Mihajlo Djoki ć Maja Čemažar Gregor Ser ša Source Type: research

Magnetic challenge against gastroesophageal reflux
World J Gastroenterol. 2021 Dec 28;27(48):8227-8241. doi: 10.3748/wjg.v27.i48.8227.ABSTRACTAlmost 15 years have passed since the first paper on the possibility of using magnets to prevent gastro-esophageal reflux (GER) was published and so it is time to assess the results obtained with the first magnetic device available on the market, the Linx magnetic sphincter augmentation (MSA) and to consider what other options are forthcoming. MSA demonstrated an anti-reflux activity similar to that of Nissen fundoplication, considered the "gold standard" surgical treatment for GER disease, and caused less gas-bloating and ...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Mauro Bortolotti Source Type: research

Emerging therapeutic options in inflammatory bowel disease
World J Gastroenterol. 2021 Dec 28;27(48):8242-8261. doi: 10.3748/wjg.v27.i48.8242.ABSTRACTInflammatory bowel disease (IBD) is a chronic disease that requires chronic treatment throughout the evolution of the disease, with a complex physiopathology that entails great challenges for the development of new and specific treatments for ulcerative colitis and Crohn´s disease. The anti-tumor necrosis factor alpha therapy has impacted the clinical course of IBD in those patients who do not respond to conventional treatment, so there is a need to develop new therapies and markers of treatment response. Various pathways invol...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Jesus K Yamamoto-Furusho Norma N Parra-Holgu ín Source Type: research

Issues of origin, morphology and clinical significance of tumor microvessels in gastric cancer
World J Gastroenterol. 2021 Dec 28;27(48):8262-8282. doi: 10.3748/wjg.v27.i48.8262.ABSTRACTGastric cancer (GC) remains a serious oncological problem, ranking third in the structure of mortality from malignant neoplasms. Improving treatment outcomes for this pathology largely depends on understanding the pathogenesis and biological characteristics of GC, including the identification and characterization of diagnostic, prognostic, predictive, and therapeutic biomarkers. It is known that the main cause of death from malignant neoplasms and GC, in particular, is tumor metastasis. Given that angiogenesis is a critical process f...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Marina A Senchukova Source Type: research

Reciprocal interactions between gut microbiota and autophagy
World J Gastroenterol. 2021 Dec 28;27(48):8283-8301. doi: 10.3748/wjg.v27.i48.8283.ABSTRACTA symbiotic relationship has set up between the gut microbiota and its host in the course of evolution, forming an interkingdom consortium. The gut offers a favorable ecological niche for microbial communities, with the whole body and external factors (e.g., diet or medications) contributing to modulating this microenvironment. Reciprocally, the gut microbiota is important for maintaining health by acting not only on the gut mucosa but also on other organs. However, failure in one or another of these two partners can lead to the brea...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Pierre Lapaquette Jean-Baptiste Bizeau Niyazi Acar Marie-Agn ès Bringer Source Type: research

Hepatitis B core antigen modulates exosomal miR-135a to target vesicle-associated membrane protein 2 promoting chemoresistance in hepatocellular carcinoma
CONCLUSION: These data suggested that HBc upregulated the expression of exosomal miR-135a-5p and promoted anti-apoptosis, cell proliferation, and chemical resistance through miR-135a-5p/VAMP2. Thus, our work indicated an essential role of the miR-135a-5p/VAMP2 regulatory axis in chemotherapy resistance of HCC and a potential molecular therapeutic target for HCC.PMID:35068871 | PMC:PMC8717014 | DOI:10.3748/wjg.v27.i48.8302 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Xiao-Cui Wei Ya-Ru Xia Ping Zhou Xing Xue Shuang Ding Li-Juan Liu Fan Zhu Source Type: research

Dual therapy with zinc acetate and rifaximin prevents from ethanol-induced liver fibrosis by maintaining intestinal barrier integrity
CONCLUSION: Dual therapy with zinc acetate and rifaximin may serve as a strategy to prevent ALD-related fibrosis by maintaining intestinal barrier integrity.PMID:35068872 | PMC:PMC8717023 | DOI:10.3748/wjg.v27.i48.8323 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Yuki Fujimoto Kosuke Kaji Norihisa Nishimura Masahide Enomoto Koji Murata Soichi Takeda Hiroaki Takaya Hideto Kawaratani Kei Moriya Tadashi Namisaki Takemi Akahane Hitoshi Yoshiji Source Type: research

Combination of squamous cell carcinoma antigen immunocomplex and alpha-fetoprotein in mid- and long-term prediction of hepatocellular carcinoma among cirrhotic patients
CONCLUSION: We have constructed a predictive model based on the combination of SCCA-IgM and AFP that provides a new HCC screening method, which could be followed by tailored HCC surveillance for individual patients, especially for those cirrhotic patients belonging to the subgroup identified as low-risk of HCC development.PMID:35068873 | PMC:PMC8717022 | DOI:10.3748/wjg.v27.i48.8343 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Antonio Gil-G ómez Ángela Rojas Chang-Hai Liu Rocio Gallego-Duran Rocio Mu ñoz-Hernandez Giorgio Fassina Patrizia Pontisso Javier Ampuero Manuel Romero-G ómez Source Type: research

New prognostic model for patients with advanced gastric cancer: Fluoropyrimidine/platinum doublet for first-line chemotherapy
World J Gastroenterol. 2021 Dec 28;27(48):8357-8369. doi: 10.3748/wjg.v27.i48.8357.ABSTRACTBACKGROUND: New prognostic factors have been reported in patients with metastatic or recurrent gastric cancer (MRGC), necessitating modifications to the previous prognostic model.AIM: To develop a new model, MRGC patients who received fluoropyrimidines/ platinum doublet chemotherapy between 2008 and 2015 were analyzed.METHODS: A total of 1883 patients was divided into a training set (n = 937) and an independent validation set (n = 946).RESULTS: Multivariate analysis showed that the following six factors were associated with poor over...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Dong-Hoe Koo Min-Hee Ryu Mi-Yeon Lee Mee-Sun Moon Yoon-Koo Kang Source Type: research

Strategy for the control of drug-induced liver injury due to investigational treatments/drugs for COVID-19
World J Gastroenterol. 2021 Dec 28;27(48):8370-8373. doi: 10.3748/wjg.v27.i48.8370.ABSTRACTInvestigational treatments/drugs for coronavirus disease 2019 (COVID-19) have been applied, with repurposed or newly developed drugs, and their effectiveness has been evaluated. Some of these drugs may be hepatotoxic, and each monotherapy or combination therapy may increase the risk of drug-induced liver injury (DILI). We should aim to control dysregulation of liver function, as well as the progression of COVID-19, as much as possible. We discussed the potential risks of investigational treatments/drugs and promising drugs for both C...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Ken Sato Yuichi Yamazaki Toshio Uraoka Source Type: research

Use of oral contraceptives and risk of pancreatic cancer in women: A recalculated meta-analysis of prospective cohort studies
World J Gastroenterol. 2021 Dec 28;27(48):8374-8377. doi: 10.3748/wjg.v27.i48.8374.ABSTRACTIn a recent systematic review and meta-analysis of observational studies, the author found potential errors in the selection and extraction processes. The recalculated summary relative risks and the results of a dose-response meta-analysis showed that oral contraceptive use may not be associated with the risk of pancreatic cancer in women.PMID:35068876 | PMC:PMC8717024 | DOI:10.3748/wjg.v27.i48.8374 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Jong-Myon Bae Source Type: research

Progress in elucidating the relationship between < em > Helicobacter pylori < /em > infection and intestinal diseases
World J Gastroenterol. 2021 Dec 21;27(47):8040-8046. doi: 10.3748/wjg.v27.i47.8040.ABSTRACTHelicobacter pylori (H. pylori) infection causes changes to the intestinal flora, such as small intestinal bacterial overgrowth, and increases gastric acid secretion-stimulating gastrointestinal hormones, mainly gastrin, due to a decrease in gastric acid caused by atrophic gastritis. In addition, the cellular components of H. pylori travel through the intestinal tract, so the bacterial infection affects the immune system. Therefore, the effects of H. pylori infection are observed not only in the stomach and the proximal duodenum but ...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Shunji Fujimori Source Type: research

Orphan patients with inflammatory bowel disease - when we treat beyond evidence
World J Gastroenterol. 2021 Dec 21;27(47):8047-8057. doi: 10.3748/wjg.v27.i47.8047.ABSTRACTInflammatory bowel disease (IBD) is a chronic condition that requires continuous medical treatment. To date, the medical management of patients with moderately-to-severely active IBD who develop dependence or resistance to corticosteroids is based on immunomodulator drugs. Such therapies are licenced after passing through three phases of randomized controlled trials (RCTs), and are subsequently adopted in clinical practice. However, the real-life population of IBD patients who require these therapies can significantly differ from tho...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Giuseppe Privitera Daniela Pugliese Loris Riccardo Lopetuso Franco Scaldaferri Alfredo Papa Gian Lodovico Rapaccini Antonio Gasbarrini Alessandro Armuzzi Source Type: research

Analogies between medusa and single port surgery in gastroenterology and hepatology: A review
World J Gastroenterol. 2021 Dec 21;27(47):8058-8068. doi: 10.3748/wjg.v27.i47.8058.ABSTRACTSingle port surgery (SPS) was introduced as an attractive, minimally invasive surgical technique that ensures esthetic results for many types of visceral surgery. Initially, surgeons immediately set about performing SPS without preliminary knowledge or training, which resulted in higher complication rates. Today, current studies conclusively show that SPS is scientifically rehabilitated and indicated for simple and complex laparoscopic procedures. We here describe the astonishing analogies between Greek mythology and modern surgery.P...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Christof Mittermair Helmut G Weiss Source Type: research

Chinese expert consensus on neoadjuvant and conversion therapies for hepatocellular carcinoma
World J Gastroenterol. 2021 Dec 21;27(47):8069-8080. doi: 10.3748/wjg.v27.i47.8069.ABSTRACTThe low resection and high recurrence rates in hepatocellular carcinoma (HCC) are the major challenges to improving prognosis. Neoadjuvant and conversion therapies are underlying strategies to overcome these challenges. To date, no guideline or consensus has been published on the neoadjuvant and conversion therapies in HCC. Recent studies showed that neoadjuvant therapy for resectable HCC and conversion therapy for unresectable HCC are safe, feasible, and effective. Neoadjuvant and conversion therapies have the following advantages i...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Hai-Tao Zhao Jian-Qiang Cai Source Type: research

Present and future management of viral hepatitis
World J Gastroenterol. 2021 Dec 21;27(47):8081-8102. doi: 10.3748/wjg.v27.i47.8081.ABSTRACTViral hepatitis can result in important morbidity and mortality, with its impact on health conditioned by the specific type of hepatitis, the geographical region of presentation and the development and access to new drugs, among other factors. Most acute presentation forms are self-limiting and may even go unnoticed, with just a small percentage of cases leading to acute liver failure that may necessitate transplantation or even cause the death of the patient. However, when they become chronic, as in the case of hepatitis B virus and...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Roc ío González Grande Inmaculada Santaella Leiva Susana L ópez Ortega Miguel Jim énez Pérez Source Type: research

Artificial intelligence-assisted colonoscopy: A review of current state of practice and research
This article takes a closer look at the current state of AI integration into the field of colonoscopy and offers suggestions for future research.PMID:35068857 | PMC:PMC8704267 | DOI:10.3748/wjg.v27.i47.8103 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Mahsa Taghiakbari Yuichi Mori Daniel von Renteln Source Type: research

Immunotherapies for well-differentiated grade 3 gastroenteropancreatic neuroendocrine tumors: A new category in the World Health Organization classification
World J Gastroenterol. 2021 Dec 21;27(47):8123-8137. doi: 10.3748/wjg.v27.i47.8123.ABSTRACTAccording to the 2019 World Health Organization (WHO) classification, well-differentiated grade 3 (G3) gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) are a new category of cancer of the digestive system. G3 GEP-NET research and treatment are not as robust as those of lower grade (G1/2) NETs and poorly differentiated neuroendocrine carcinomas (NECs). Previously, the management of high-grade NETs was mainly based on NEC therapies, as high-grade NETs were classified as NECs under the previous WHO classification. Despite this,...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Jun-Xi Xu De-Hao Wu Li-Wei Ying Han-Guang Hu Source Type: research

Impact of intrarectal chromofungin treatment on dendritic cells-related markers in different immune compartments in colonic inflammatory conditions
CONCLUSION: CHR has protective properties against intestinal inflammation via the regulation of DC-related markers and CD11c+ cells. CHR could be a potential therapy of UC.PMID:35068859 | PMC:PMC8704268 | DOI:10.3748/wjg.v27.i47.8138 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Kunal Kapoor Nour Eissa Diane Tshikudi Charles N Bernstein Jean-Eric Ghia Source Type: research

Multiparameter magnetic resonance imaging of liver fibrosis in a bile duct ligation mouse model
World J Gastroenterol. 2021 Dec 21;27(47):8156-8165. doi: 10.3748/wjg.v27.i47.8156.ABSTRACTBACKGROUND: Bile duct ligation (BDL) in animals is a classical method for mimicking cholestatic fibrosis. Although different surgical techniques have been described in rats and rabbits, mouse models can be more cost-effective and reproducible for investigating cholestatic fibrosis. Magnetic resonance imaging (MRI) has made great advances for noninvasive assessment of liver fibrosis. More comprehensive liver fibrotic features of BDL on MRI are important. However, the utility of multiparameter MRI to detect liver fibrosis in a BDL mous...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Jia-Yi Liu Zhu-Yuan Ding Zi-Yi Zhou Sheng-Zhen Dai Jie Zhang Hao Li Qiu Du Ye-Yu Cai Quan-Liang Shang Yong-Heng Luo En-Hua Xiao Source Type: research

Disease control and failure patterns of unresectable hepatocellular carcinoma following transarterial radioembolization with yttrium-90 microspheres and with/without sorafenib
World J Gastroenterol. 2021 Dec 21;27(47):8166-8181. doi: 10.3748/wjg.v27.i47.8166.ABSTRACTBACKGROUND: Impressive survival outcome of our previous study in unresectable hepatocellular carcinoma (HCC) patients undergoing yttrium-90 glass microspheres transarterial radioembolization (TARE) with/without sorafenib according to individuals' disease burden, i.e., intrahepatic tumor load (IHT) and adverse disease features (ADFs) might partly be confounded by other treatments and underlying hepatic function. Therefore, a dedicated study focusing on treatment response and assessment of failure patterns might be a way to improve tre...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Ajalaya Teyateeti Armeen Mahvash James Long Mohamed Abdelsalam Rony Avritscher Ahmed Kaseb Bruno Odisio Gregory Ravizzini Devaki Surasi Achiraya Teyateeti Homer Macapinlac Srinivas Cheenu Kappadath Source Type: research

Real-world local recurrence rate after cold polypectomy in colorectal polyps less than 10 mm using propensity score matching
CONCLUSION: Local recurrence after CP was equivalent to that following HP in clinical practice. CP is useful and safe in the treatment of non-pedunculated polyps of less than 10 mm.PMID:35068862 | PMC:PMC8704276 | DOI:10.3748/wjg.v27.i47.8182 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Masashi Saito Takeshi Yamamura Masanao Nakamura Keiko Maeda Tsunaki Sawada Eri Ishikawa Yasuyuki Mizutani Takuya Ishikawa Naomi Kakushima Kazuhiro Furukawa Eizaburo Ohno Hiroki Kawashima Masatoshi Ishigami Mitsuhiro Fujishiro Source Type: research

Microarray analysis to explore the effect of < em > CXCL12 < /em > isoforms in a pancreatic pre-tumor cell model
World J Gastroenterol. 2021 Dec 21;27(47):8194-8198. doi: 10.3748/wjg.v27.i47.8194.ABSTRACTCXCL12 expression was significantly lower in tumor samples than in corresponding normal samples. CXCL12 expression was significantly positively related to the infiltration levels of T cells, dendritic cells (DCs), immature DCs, cytotoxic cells, Tfh cells, mast cells, B cells, Th1 cells, natural killer (NK) cells, pDCs, neutrophils, and T helper cells (Spearman correlation coefficient> 0.5, P
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Yan-Dong Miao Jiang-Tao Wang Xiao-Long Tang Deng-Hai Mi Source Type: research

Progress on global hepatitis elimination targets
World J Gastroenterol. 2021 Dec 21;27(47):8199-8200. doi: 10.3748/wjg.v27.i47.8199.ABSTRACTIn 2016, the World Health Assembly adopted a Global Health Sector Strategy on viral hepatitis, with targets set for the years 2020 and 2030 to achieve hepatitis elimination. The main target of hepatitis elimination strategy is to reduce the incidence of hepatitis B virus (HBV) and hepatitis C virus (HCV) by 90% and mortality by 65% in 2030. In last 5 years, the number of people receiving HCV treatment has increased from 1 million to 9.4 million; however, this number is far from the 2030 target of 40 million people receiving HCV treat...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Yasir Waheed Source Type: research

Palmitoylation in Crohn's disease: Current status and future directions
World J Gastroenterol. 2021 Dec 28;27(48):8201-8215. doi: 10.3748/wjg.v27.i48.8201.ABSTRACTS-palmitoylation is one of the most common post-translational modifications in nature; however, its importance has been overlooked for decades. Crohn's disease (CD), a subtype of inflammatory bowel disease (IBD), is an autoimmune disease characterized by chronic inflammation involving the entire gastrointestinal tract. Bowel damage and subsequent disabilities caused by CD are a growing global health issue. Well-acknowledged risk factors for CD include genetic susceptibility, environmental factors, such as a westernized lifestyle, and...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Wei-Xin Cheng Yue Ren Miao-Miao Lu Ling-Ling Xu Jian-Guo Gao Dong Chen Farhin Shaheed Kalyani Zi-Yan Lv Chun-Xiao Chen Feng Ji He-Ning Lin Xi Jin Source Type: research

New era of electrochemotherapy in treatment of liver tumors in conjunction with immunotherapies
World J Gastroenterol. 2021 Dec 28;27(48):8216-8226. doi: 10.3748/wjg.v27.i48.8216.ABSTRACTElectrochemotherapy is a local ablative therapy that increases the cytotoxicity of either bleomycin or cisplatin by applying electric pulses (electroporation) to tumors. It has already been widely used throughout Europe for the treatment of various types of human and veterinary cutaneous tumors, with an objective response rate ranging from 70%-90%, depending on the tumor histotype. Recently, electrochemotherapy was introduced for the treatment of primary liver tumors, such as hepatocellular carcinoma (HCC). The complete response rate...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Bla ž Trotovšek Mihajlo Djoki ć Maja Čemažar Gregor Ser ša Source Type: research

Magnetic challenge against gastroesophageal reflux
World J Gastroenterol. 2021 Dec 28;27(48):8227-8241. doi: 10.3748/wjg.v27.i48.8227.ABSTRACTAlmost 15 years have passed since the first paper on the possibility of using magnets to prevent gastro-esophageal reflux (GER) was published and so it is time to assess the results obtained with the first magnetic device available on the market, the Linx magnetic sphincter augmentation (MSA) and to consider what other options are forthcoming. MSA demonstrated an anti-reflux activity similar to that of Nissen fundoplication, considered the "gold standard" surgical treatment for GER disease, and caused less gas-bloating and ...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Mauro Bortolotti Source Type: research

Emerging therapeutic options in inflammatory bowel disease
World J Gastroenterol. 2021 Dec 28;27(48):8242-8261. doi: 10.3748/wjg.v27.i48.8242.ABSTRACTInflammatory bowel disease (IBD) is a chronic disease that requires chronic treatment throughout the evolution of the disease, with a complex physiopathology that entails great challenges for the development of new and specific treatments for ulcerative colitis and Crohn´s disease. The anti-tumor necrosis factor alpha therapy has impacted the clinical course of IBD in those patients who do not respond to conventional treatment, so there is a need to develop new therapies and markers of treatment response. Various pathways invol...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Jesus K Yamamoto-Furusho Norma N Parra-Holgu ín Source Type: research

Issues of origin, morphology and clinical significance of tumor microvessels in gastric cancer
World J Gastroenterol. 2021 Dec 28;27(48):8262-8282. doi: 10.3748/wjg.v27.i48.8262.ABSTRACTGastric cancer (GC) remains a serious oncological problem, ranking third in the structure of mortality from malignant neoplasms. Improving treatment outcomes for this pathology largely depends on understanding the pathogenesis and biological characteristics of GC, including the identification and characterization of diagnostic, prognostic, predictive, and therapeutic biomarkers. It is known that the main cause of death from malignant neoplasms and GC, in particular, is tumor metastasis. Given that angiogenesis is a critical process f...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Marina A Senchukova Source Type: research

Reciprocal interactions between gut microbiota and autophagy
World J Gastroenterol. 2021 Dec 28;27(48):8283-8301. doi: 10.3748/wjg.v27.i48.8283.ABSTRACTA symbiotic relationship has set up between the gut microbiota and its host in the course of evolution, forming an interkingdom consortium. The gut offers a favorable ecological niche for microbial communities, with the whole body and external factors (e.g., diet or medications) contributing to modulating this microenvironment. Reciprocally, the gut microbiota is important for maintaining health by acting not only on the gut mucosa but also on other organs. However, failure in one or another of these two partners can lead to the brea...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Pierre Lapaquette Jean-Baptiste Bizeau Niyazi Acar Marie-Agn ès Bringer Source Type: research

Hepatitis B core antigen modulates exosomal miR-135a to target vesicle-associated membrane protein 2 promoting chemoresistance in hepatocellular carcinoma
CONCLUSION: These data suggested that HBc upregulated the expression of exosomal miR-135a-5p and promoted anti-apoptosis, cell proliferation, and chemical resistance through miR-135a-5p/VAMP2. Thus, our work indicated an essential role of the miR-135a-5p/VAMP2 regulatory axis in chemotherapy resistance of HCC and a potential molecular therapeutic target for HCC.PMID:35068871 | PMC:PMC8717014 | DOI:10.3748/wjg.v27.i48.8302 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Xiao-Cui Wei Ya-Ru Xia Ping Zhou Xing Xue Shuang Ding Li-Juan Liu Fan Zhu Source Type: research

Dual therapy with zinc acetate and rifaximin prevents from ethanol-induced liver fibrosis by maintaining intestinal barrier integrity
CONCLUSION: Dual therapy with zinc acetate and rifaximin may serve as a strategy to prevent ALD-related fibrosis by maintaining intestinal barrier integrity.PMID:35068872 | PMC:PMC8717023 | DOI:10.3748/wjg.v27.i48.8323 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Yuki Fujimoto Kosuke Kaji Norihisa Nishimura Masahide Enomoto Koji Murata Soichi Takeda Hiroaki Takaya Hideto Kawaratani Kei Moriya Tadashi Namisaki Takemi Akahane Hitoshi Yoshiji Source Type: research

Combination of squamous cell carcinoma antigen immunocomplex and alpha-fetoprotein in mid- and long-term prediction of hepatocellular carcinoma among cirrhotic patients
CONCLUSION: We have constructed a predictive model based on the combination of SCCA-IgM and AFP that provides a new HCC screening method, which could be followed by tailored HCC surveillance for individual patients, especially for those cirrhotic patients belonging to the subgroup identified as low-risk of HCC development.PMID:35068873 | PMC:PMC8717022 | DOI:10.3748/wjg.v27.i48.8343 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Antonio Gil-G ómez Ángela Rojas Chang-Hai Liu Rocio Gallego-Duran Rocio Mu ñoz-Hernandez Giorgio Fassina Patrizia Pontisso Javier Ampuero Manuel Romero-G ómez Source Type: research

New prognostic model for patients with advanced gastric cancer: Fluoropyrimidine/platinum doublet for first-line chemotherapy
World J Gastroenterol. 2021 Dec 28;27(48):8357-8369. doi: 10.3748/wjg.v27.i48.8357.ABSTRACTBACKGROUND: New prognostic factors have been reported in patients with metastatic or recurrent gastric cancer (MRGC), necessitating modifications to the previous prognostic model.AIM: To develop a new model, MRGC patients who received fluoropyrimidines/ platinum doublet chemotherapy between 2008 and 2015 were analyzed.METHODS: A total of 1883 patients was divided into a training set (n = 937) and an independent validation set (n = 946).RESULTS: Multivariate analysis showed that the following six factors were associated with poor over...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Dong-Hoe Koo Min-Hee Ryu Mi-Yeon Lee Mee-Sun Moon Yoon-Koo Kang Source Type: research

Strategy for the control of drug-induced liver injury due to investigational treatments/drugs for COVID-19
World J Gastroenterol. 2021 Dec 28;27(48):8370-8373. doi: 10.3748/wjg.v27.i48.8370.ABSTRACTInvestigational treatments/drugs for coronavirus disease 2019 (COVID-19) have been applied, with repurposed or newly developed drugs, and their effectiveness has been evaluated. Some of these drugs may be hepatotoxic, and each monotherapy or combination therapy may increase the risk of drug-induced liver injury (DILI). We should aim to control dysregulation of liver function, as well as the progression of COVID-19, as much as possible. We discussed the potential risks of investigational treatments/drugs and promising drugs for both C...
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Ken Sato Yuichi Yamazaki Toshio Uraoka Source Type: research

Use of oral contraceptives and risk of pancreatic cancer in women: A recalculated meta-analysis of prospective cohort studies
World J Gastroenterol. 2021 Dec 28;27(48):8374-8377. doi: 10.3748/wjg.v27.i48.8374.ABSTRACTIn a recent systematic review and meta-analysis of observational studies, the author found potential errors in the selection and extraction processes. The recalculated summary relative risks and the results of a dose-response meta-analysis showed that oral contraceptive use may not be associated with the risk of pancreatic cancer in women.PMID:35068876 | PMC:PMC8717024 | DOI:10.3748/wjg.v27.i48.8374 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 24, 2022 Category: Gastroenterology Authors: Jong-Myon Bae Source Type: research