Current understanding of the impact of COVID-19 on gastrointestinal disease: Challenges and openings
World J Gastroenterol. 2021 Feb 14;27(6):449-469. doi: 10.3748/wjg.v27.i6.449.ABSTRACTThe novel coronavirus disease-2019 (COVID-19) is caused by a positive-sense single-stranded RNA virus which belongs to the Coronaviridae family. In March 2019 the World Health Organization declared that COVID-19 was a pandemic. COVID-19 patients typically have a fever, dry cough, dyspnea, fatigue, and anosmia. Some patients also report gastrointestinal (GI) symptoms, including diarrhea, nausea, vomiting, and abdominal pain, as well as liver enzyme abnormalities. Surprisingly, many studies have found severe acute respiratory syndrome coron...
Source: World Journal of Gastroenterology : WJG - March 1, 2021 Category: Gastroenterology Authors: Tarun Sahu Arundhati Mehta Yashwant Kumar Ratre Akriti Jaiswal Naveen Kumar Vishvakarma Lakkakula Venkata Kameswara Subrahmanya Bhaskar Henu Kumar Verma Source Type: research

Demethylation of miR-34a upregulates expression of membrane palmitoylated proteins and promotes the apoptosis of liver cancer cells
CONCLUSION: miR-34a demethylation upregulates the expression level of MPP2 in liver cancer cells and promotes the apoptosis of liver cancer cells. miR-34a demethylation is a potential method for liver cancer treatment.PMID:33642822 | PMC:PMC7896437 | DOI:10.3748/wjg.v27.i6.470 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 1, 2021 Category: Gastroenterology Authors: Fu-Yong Li Ting-Yong Fan Hao Zhang Yu-Min Sun Source Type: research

Circular RNA circVAPA promotes chemotherapy drug resistance in gastric cancer progression by regulating miR-125b-5p/STAT3 axis
CONCLUSION: CircVAPA promotes chemotherapy resistance and malignant progression in GC by miR-125b-5p/STAT3 signaling. Our findings present novel insights into the mechanism by which circVAPA regulates chemotherapy resistance of GC cells. CircVAPA and miR-125b-5p may be considered as the potential targets for GC therapy.PMID:33642823 | PMC:PMC7896438 | DOI:10.3748/wjg.v27.i6.487 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 1, 2021 Category: Gastroenterology Authors: Peng Deng Ming Sun Wen-Yan Zhao Bin Hou Kai Li Tao Zhang Feng Gu Source Type: research

Validation of serum tumor biomarkers in predicting advanced cystic mucinous neoplasm of the pancreas
CONCLUSION: CA19-9 has a moderate ability, and CEA, CA125, and CA724 have a low ability to predict A-cMNs. The combination of STM testing could improve SE in predicting A-cMNs.PMID:33642824 | PMC:PMC7896439 | DOI:10.3748/wjg.v27.i6.501 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 1, 2021 Category: Gastroenterology Authors: Li-Qi Sun Li-Si Peng Jie-Fang Guo Fei Jiang Fang Cui Hao-Jie Huang Zhen-Dong Jin Source Type: research

Washed microbiota transplantation reduces proton pump inhibitor dependency in nonerosive reflux disease
CONCLUSION: This study is the first to demonstrate that WMT may be safe and effective for relieving NERD symptoms and reducing PPI dependency and recurrence.PMID:33642825 | PMC:PMC7896436 | DOI:10.3748/wjg.v27.i6.513 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 1, 2021 Category: Gastroenterology Authors: Ya-Mei Zheng Xian-Yun Chen Jie-Yi Cai Yu Yuan Wen-Rui Xie Jia-Ting Xu Harry Hua-Xiang Xia Min Zhang Xing-Xiang He Li-Hao Wu Source Type: research

Prevalence of advanced liver fibrosis and steatosis in type-2 diabetics with normal transaminases: A prospective cohort study
World J Gastroenterol. 2021 Feb 14;27(6):523-533. doi: 10.3748/wjg.v27.i6.523.ABSTRACTBACKGROUND: Nonalcoholic fatty liver disease (NAFLD) and type-2 diabetes mellitus (T2DM) have an intricate bidirectional relationship. Individuals with T2DM, not only have a higher prevalence of non-alcoholic steatosis, but also carry a higher risk of progression to nonalcoholic steatohepatitis. Experts still differ in their recommendations of screening for NAFLD among patients with T2DM.AIM: To study the prevalence of NAFLD and advanced fibrosis among our patient population with T2DM.METHODS: During the study period (November 2018 to Jan...
Source: World Journal of Gastroenterology : WJG - March 1, 2021 Category: Gastroenterology Authors: Jasbir Makker Hassan Tariq Kishore Kumar Madhavi Ravi Danial Haris Shaikh Vivien Leung Umar Hayat Muhammad T Hassan Harish Patel Suresh Nayudu Sridhar Chilimuri Source Type: research

Pancreaticoduodenectomy after neoadjuvant chemotherapy for gastric cancer invading the pancreatic head: A case report
CONCLUSION: We suggest that radical resection with PD after neoadjuvant chemotherapy plus trastuzumab is an option for locally advanced HER2-positive gastric cancer invading the pancreatic head in the absence of non-curative factors.PMID:33642827 | PMC:PMC7896433 | DOI:10.3748/wjg.v27.i6.534 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 1, 2021 Category: Gastroenterology Authors: Masahiro Yura Kiminori Takano Kiyohiko Adachi Asuka Hara Keita Hayashi Yuki Tajima Yasushi Kaneko Yoichiro Ikoma Hiroto Fujisaki Akira Hirata Kumiko Hongo Kikuo Yo Kimiyasu Yoneyama Reiko Dehari Kazuo Koyanagi Motohito Nakagawa Source Type: research

< em > Helicobacter pylori < /em > : Commensal, symbiont or pathogen?
World J Gastroenterol. 2021 Feb 21;27(7):545-560. doi: 10.3748/wjg.v27.i7.545.ABSTRACTThis review considers the data on Helicobacter pylori (H. pylori), which have been accumulated over 40 years since its description as an etiological factor in gastrointestinal diseases. The majority of modern publications are devoted to the study of the pathogenic properties of the microorganism in the development of chronic gastritis, peptic ulcer disease, and gastric cancer, as well as methods for its eradication. However, in recent years, there have been more and more studies which have suggested that H. pylori has a beneficial, or pot...
Source: World Journal of Gastroenterology : WJG - March 1, 2021 Category: Gastroenterology Authors: Vasiliy Ivanovich Reshetnyak Alexandr Igorevich Burmistrov Igor Veniaminovich Maev Source Type: research

Digestive system involvement of infections with SARS-CoV-2 and other coronaviruses: Clinical manifestations and potential mechanisms
World J Gastroenterol. 2021 Feb 21;27(7):561-575. doi: 10.3748/wjg.v27.i7.561.ABSTRACTAlthough coronavirus (CoV) infection is often characterized by respiratory symptoms, the virus can also result in extrapulmonary symptoms, especially the symptoms related to the digestive system. The outbreak of coronavirus disease 2019 (COVID-19) is currently the world's most pressing public health threat and has a significant impact on civil societies and the global economy. The occurrence of digestive symptoms in patients with COVID-19 is closely related to the development and prognosis of the disease. Moreover, thus far, there are no ...
Source: World Journal of Gastroenterology : WJG - March 1, 2021 Category: Gastroenterology Authors: Gao-Feng Zhan Yue Wang Ning Yang Ai-Lin Luo Shi-Yong Li Source Type: research

Xiangbinfang granules enhance gastric antrum motility < em > via < /em > intramuscular interstitial cells of Cajal in mice
World J Gastroenterol. 2021 Feb 21;27(7):576-591. doi: 10.3748/wjg.v27.i7.576.ABSTRACTBACKGROUND: Interdigestive migrating motor complexes (MMC) produce periodic contractions in the gastrointestinal tract, but the exact mechanism of action still remains unclear. Intramuscular interstitial cells of Cajal (ICC-IM) participate in gastrointestinal hormone and neuromodulation, but the correlation between ICC-IM and MMC is also unclear. We found that xiangbinfang granules (XBF) mediated the phase III contraction of MMC. Here, the effects of XBF on gastric antrum motility in W/W v mice and the effects of ICC-IM on gastric antrum ...
Source: World Journal of Gastroenterology : WJG - March 1, 2021 Category: Gastroenterology Authors: Qi-Cheng Chen Zhi Jiang Jun-Hong Zhang Li-Xing Cao Zhi-Qiang Chen Source Type: research

Sinapic acid ameliorates D-galactosamine/lipopolysaccharide-induced fulminant hepatitis in rats: Role of nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways
CONCLUSION: In conclusion, SA offers significant protection against LPS/D-GalN-induced ALF in rats by upregulating Nrf2/HO-1 and downregulating NF-κB.PMID:33642831 | PMC:PMC7901048 | DOI:10.3748/wjg.v27.i7.592 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 1, 2021 Category: Gastroenterology Authors: Mushtaq Ahmad Ansari Mohammad Raish Yousef A Bin Jardan Ajaz Ahmad Mudassar Shahid Sheikh Fayaz Ahmad Nazrul Haq Mohammad Rashid Khan Saleh A Bakheet Source Type: research

Quantitative multiparametric magnetic resonance imaging can aid non-alcoholic steatohepatitis diagnosis in a Japanese cohort
CONCLUSION: Quantitative mpMRI is an effective alternative to liver biopsy for diagnosing NASH and non-alcoholic fatty liver, and thus may offer clinical utility in patient management.PMID:33642832 | PMC:PMC7901049 | DOI:10.3748/wjg.v27.i7.609 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 1, 2021 Category: Gastroenterology Authors: Kento Imajo Louise Tetlow Andrea Dennis Elizabeth Shumbayawonda Sofia Mouchti Timothy J Kendall Eve Fryer Shogi Yamanaka Yasushi Honda Takaomi Kessoku Yuji Ogawa Masato Yoneda Satoru Saito Catherine Kelly Matt D Kelly Rajarshi Banerjee Atsushi Nakajima Source Type: research

Clinicopathological features and prognostic factors associated with gastroenteropancreatic mixed neuroendocrine non-neuroendocrine neoplasms in Chinese patients
CONCLUSION: A poor prognosis is associated with rare, aggressive GEP-MiNEN. Ki-67 index, tumor composition, lymph node involvement, distant metastasis, and clinical stage are important factors for patient prognosis.PMID:33642833 | PMC:PMC7901054 | DOI:10.3748/wjg.v27.i7.624 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 1, 2021 Category: Gastroenterology Authors: Yu-Chen Huang Ning-Ning Yang Hong-Chun Chen Yuan-Li Huang Wen-Tian Yan Ru-Xue Yang Nan Li Shan Zhang Pan-Pan Yang Zhen-Zhong Feng Source Type: research

Effect of liver inflammation on accuracy of FibroScan device in assessing liver fibrosis stage in patients with chronic hepatitis B virus infection
World J Gastroenterol. 2021 Feb 21;27(7):641-653. doi: 10.3748/wjg.v27.i7.641.ABSTRACTBACKGROUND: Transient elastography (FibroScan) is a new and non-invasive test, which has been widely recommended by the guidelines of chronic hepatitis B virus (HBV) management for assessing hepatic fibrosis staging. However, some confounders may affect the diagnostic accuracy of the FibroScan device in fibrosis staging.AIM: To evaluate the diagnostic value of the FibroScan device and the effect of hepatic inflammation on the accuracy of FibroScan in assessing the stage of liver fibrosis in patients with HBV infection.METHODS: The data of...
Source: World Journal of Gastroenterology : WJG - March 1, 2021 Category: Gastroenterology Authors: Ling-Ling Huang Xue-Ping Yu Ju-Lan Li Hui-Ming Lin Na-Ling Kang Jia-Ji Jiang Yue-Yong Zhu Yu-Rui Liu Da-Wu Zeng Source Type: research

Simultaneous partial splenectomy during liver transplantation for advanced cirrhosis patients combined with severe splenomegaly and hypersplenism
CONCLUSION: Simultaneous PSLT is an effective treatment and should be performed in patients with advanced cirrhosis combined with severe splenomegaly and hypersplenism to prevent postoperative persistent hypersplenism.PMID:33642835 | PMC:PMC7901050 | DOI:10.3748/wjg.v27.i7.654 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 1, 2021 Category: Gastroenterology Authors: Wen-Tao Jiang Jian Yang Yan Xie Qing-Jun Guo Da-Zhi Tian Jun-Jie Li Zhong-Yang Shen Source Type: research

Pleiotropy within gene variants associated with nonalcoholic fatty liver disease and traits of the hematopoietic system
World J Gastroenterol. 2021 Jan 28;27(4):305-320. doi: 10.3748/wjg.v27.i4.305.ABSTRACTGenome-wide association studies of complex diseases, including nonalcoholic fatty liver disease (NAFLD), have demonstrated that a large number of variants are implicated in the susceptibility of multiple traits - a phenomenon known as pleiotropy that is increasingly being explored through phenome-wide association studies. We focused on the analysis of pleiotropy within variants associated with hematologic traits and NAFLD. We used information retrieved from large public National Health and Nutrition Examination Surveys, Genome-wide associ...
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Carlos Jose Pirola Adrian Salatino Silvia Sookoian Source Type: research

Preoperative maximal voluntary ventilation, hemoglobin, albumin, lymphocytes and platelets predict postoperative survival in esophageal squamous cell carcinoma
World J Gastroenterol. 2021 Jan 28;27(4):321-335. doi: 10.3748/wjg.v27.i4.321.ABSTRACTBACKGROUND: Preoperative pulmonary function plays an important role in selecting surgical candidates and assessing postoperative complications. Reduced pulmonary function is associated with poor survival in several cancers, but the prognostic value of preoperative pulmonary function in esophageal squamous cell carcinoma (ESCC) is unclear. Nutritional and systemic inflammation parameters are vital to cancer survival, and the combination of these parameters improves the prognostic value. The hemoglobin, albumin, lymphocytes and platelets (H...
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Shou-Jia Hu Xue-Ke Zhao Xin Song Ling-Ling Lei Wen-Li Han Rui-Hua Xu Ran Wang Fu-You Zhou Liang Wang Li-Dong Wang Source Type: research

Clinic-pathological features of metabolic associated fatty liver disease with hepatitis B virus infection
World J Gastroenterol. 2021 Jan 28;27(4):336-344. doi: 10.3748/wjg.v27.i4.336.ABSTRACTBACKGROUND: Metabolic associated fatty liver disease (MAFLD) is a novel concept proposed in 2020.AIM: To compare the characteristics of MAFLD and MAFLD with hepatitis B virus (HBV) infection.METHODS: Patients with histopathologically proven MAFLD from a single medical center were included. Patients were divided into MAFLD group (without HBV infection) and HBV-MAFLD group (with HBV infection). Propensity score matching was utilized to balance the baseline characteristics between two groups.RESULTS: A total of 417 cases with MAFLD were incl...
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Ming-Fang Wang Bo Wan Yin-Lian Wu Jiao-Feng Huang Yue-Yong Zhu You-Bing Li Source Type: research

Effect of remote ischemic preconditioning among donors and recipients following pediatric liver transplantation: A randomized clinical trial
World J Gastroenterol. 2021 Jan 28;27(4):345-357. doi: 10.3748/wjg.v27.i4.345.ABSTRACTBACKGROUND: Studies suggested that remote ischemic preconditioning (RIPC) may effectively lessen the harmful effects of ischemia reperfusion injury during organ transplantation surgery.AIM: To investigate the protective effects of RIPC on living liver donors and recipients following pediatric liver transplantation.METHODS: From January 2016 to January 2019 at Renji Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, 208 donors were recruited and randomly assigned to four groups: S-RIPC group (no intervention; n = 55...
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Bo Qi Xiao-Qiang Wang Shu-Ting Pan Pei-Ying Li Ling-Ke Chen Qiang Xia Li-Qun Yang Wei-Feng Yu Source Type: research

Could saline irrigation clear all residual common bile duct stones after lithotripsy? A self-controlled prospective cohort study
CONCLUSION: Irrigation with 100 mL of saline may not clear all residual CBD stones after lithotripsy, especially in patients with PAD and/or a dilated (> 15 mm) CBD. Pigment residual stones are soft and commonly found in patients with PAD. Additional saline irrigation may be required to remove retained stones.PMID:33584068 | PMC:PMC7852583 | DOI:10.3748/wjg.v27.i4.358 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Yan-Yan Lin Yu-Dong Wang Ping Yue Xian-Zhuo Zhang Joseph W Leung Pan-Pan Jiao Man Yang Hai-Ping Wang Bing Bai Ying Liu Jin-Duo Zhang Hong-Bo Chen Wen-Bo Meng Xun Li Source Type: research

Duplication of the common bile duct manifesting as recurrent pyogenic cholangitis: A case report
CONCLUSION: In this article, we report an extremely rare case of DCBD manifesting as recurrent pyogenic cholangitis. This case highlights the importance of recognizing DCBD because stones in the unrecognized bile duct could make the patient's prognosis critical.PMID:33584069 | PMC:PMC7852585 | DOI:10.3748/wjg.v27.i4.371 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Jun Seong Hwang Sung Woo Ko Source Type: research

Liver injury in the era of COVID-19
World J Gastroenterol. 2021 Feb 7;27(5):377-390. doi: 10.3748/wjg.v27.i5.377.ABSTRACTSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has undoubtedly revolutionized the whole globe and given a new point of view on respiratory tract infections. Nevertheless, coronavirus disease 2019 (COVID-19) cannot be perceived as a disease limited only to pneumonia with diverse severity. More and more reports have demonstrated a wide range of possible systemic symptoms, including hepatic complications. Liver injury has been observed in a significant proportion of patients, especially in those with a severe or critical illness...
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Halina Cicho ż-Lach Agata Michalak Source Type: research

Changes in gut microbiota composition and diversity associated with post-cholecystectomy diarrhea
CONCLUSION: This study demonstrated that gut dysbiosis may play a critical role in PCD, which provides new insights into therapeutic options for PCD patients.PMID:33584071 | PMC:PMC7856843 | DOI:10.3748/wjg.v27.i5.391 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Yan-Dong Li Bao-Ning Liu Si-Hai Zhao Yong-Li Zhou Liang Bai En-Qi Liu Source Type: research

Histopathology and the predominantly progressive, indeterminate and predominately regressive score in hepatitis C virus patients after direct-acting antivirals therapy
CONCLUSION: Significant improvement of necroinflammation and partial remission of fibrosis in HCV patients occurred shortly after DAAs therapy. The P-I-R score has potential in predicting fibrosis in HCV patients.PMID:33584072 | PMC:PMC7856841 | DOI:10.3748/wjg.v27.i5.404 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Rui Huang Hui-Ying Rao Ming Yang Ying-Hui Gao Jian Wang Qian Jin Dan-Li Ma Lai Wei Source Type: research

Comparative study of indocyanine green-R15, Child-Pugh score, and model for end-stage liver disease score for prediction of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt
CONCLUSION: The ICG-R15 has appreciated clinical value for predicting the occurrence of post-TIPS HE and is a choice for evaluating the prognosis of patients undergoing TIPS.PMID:33584073 | PMC:PMC7856842 | DOI:10.3748/wjg.v27.i5.416 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Zhong Wang Yi-Fan Wu Zhen-Dong Yue Hong-Wei Zhao Lei Wang Zhen-Hua Fan Yu Zhang Fu-Quan Liu Source Type: research

Noninferiority clinical trial comparing the bowel cleansing efficacy of sodium phosphate tablets (Quiklean < sup > ® < /sup > ) with a polyethylene glycol/bisacodyl kit
World J Gastroenterol. 2021 Feb 7;27(5):428-441. doi: 10.3748/wjg.v27.i5.428.ABSTRACTBACKGROUND: Efficient bowel cleansing is essential for a successful colonoscopy, but the ideal cleansing agent, volume, and pharmaceutical dosage form have yet to be determined. Small-volume cleansers enhance patient compliance.AIM: To compare the bowel cleansing efficacy of 32-tablet sodium phosphate (Quiklean®) with 2-L polyethylene glycol (PEG)/bisacodyl (Klean-Prep/ Dulcolax®) under identical dietary recommendations.METHODS: This multicenter, randomized, parallel-group, noninferiority clinical trial enrolled 472 outpatients, ra...
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Shih-Ya Hung Hung-Chang Chen Tao-Wei Ke Jiann-Hwa Chen Koung-Hung Hsiao Hwei-Ming Wang Hua-Che Chiang Sheng-Chi Chang Yi-Chang Chen Ming-Hao Hsieh Yuan-Yao Tsai Yo-Wen Hsieh William Tzu-Liang Chen Source Type: research

Vedolizumab in Crohn's disease with rectal fistulas and presacral abscess: A case report
CONCLUSION: Early vedolizumab and stool diversion are effective and safe in treating CD with complex rectal fistula with abscess formation.PMID:33584075 | PMC:PMC7856844 | DOI:10.3748/wjg.v27.i5.442 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Heng Yeh Chia-Jung Kuo Ren-Chin Wu Chien-Ming Chen Wen-Sy Tsai Ming-Yao Su Cheng-Tang Chiu Puo-Hsien Le Source Type: research

Pleiotropy within gene variants associated with nonalcoholic fatty liver disease and traits of the hematopoietic system
World J Gastroenterol. 2021 Jan 28;27(4):305-320. doi: 10.3748/wjg.v27.i4.305.ABSTRACTGenome-wide association studies of complex diseases, including nonalcoholic fatty liver disease (NAFLD), have demonstrated that a large number of variants are implicated in the susceptibility of multiple traits - a phenomenon known as pleiotropy that is increasingly being explored through phenome-wide association studies. We focused on the analysis of pleiotropy within variants associated with hematologic traits and NAFLD. We used information retrieved from large public National Health and Nutrition Examination Surveys, Genome-wide associ...
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Carlos Jose Pirola Adrian Salatino Silvia Sookoian Source Type: research

Preoperative maximal voluntary ventilation, hemoglobin, albumin, lymphocytes and platelets predict postoperative survival in esophageal squamous cell carcinoma
World J Gastroenterol. 2021 Jan 28;27(4):321-335. doi: 10.3748/wjg.v27.i4.321.ABSTRACTBACKGROUND: Preoperative pulmonary function plays an important role in selecting surgical candidates and assessing postoperative complications. Reduced pulmonary function is associated with poor survival in several cancers, but the prognostic value of preoperative pulmonary function in esophageal squamous cell carcinoma (ESCC) is unclear. Nutritional and systemic inflammation parameters are vital to cancer survival, and the combination of these parameters improves the prognostic value. The hemoglobin, albumin, lymphocytes and platelets (H...
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Shou-Jia Hu Xue-Ke Zhao Xin Song Ling-Ling Lei Wen-Li Han Rui-Hua Xu Ran Wang Fu-You Zhou Liang Wang Li-Dong Wang Source Type: research

Clinic-pathological features of metabolic associated fatty liver disease with hepatitis B virus infection
World J Gastroenterol. 2021 Jan 28;27(4):336-344. doi: 10.3748/wjg.v27.i4.336.ABSTRACTBACKGROUND: Metabolic associated fatty liver disease (MAFLD) is a novel concept proposed in 2020.AIM: To compare the characteristics of MAFLD and MAFLD with hepatitis B virus (HBV) infection.METHODS: Patients with histopathologically proven MAFLD from a single medical center were included. Patients were divided into MAFLD group (without HBV infection) and HBV-MAFLD group (with HBV infection). Propensity score matching was utilized to balance the baseline characteristics between two groups.RESULTS: A total of 417 cases with MAFLD were incl...
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Ming-Fang Wang Bo Wan Yin-Lian Wu Jiao-Feng Huang Yue-Yong Zhu You-Bing Li Source Type: research

Effect of remote ischemic preconditioning among donors and recipients following pediatric liver transplantation: A randomized clinical trial
World J Gastroenterol. 2021 Jan 28;27(4):345-357. doi: 10.3748/wjg.v27.i4.345.ABSTRACTBACKGROUND: Studies suggested that remote ischemic preconditioning (RIPC) may effectively lessen the harmful effects of ischemia reperfusion injury during organ transplantation surgery.AIM: To investigate the protective effects of RIPC on living liver donors and recipients following pediatric liver transplantation.METHODS: From January 2016 to January 2019 at Renji Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, 208 donors were recruited and randomly assigned to four groups: S-RIPC group (no intervention; n = 55...
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Bo Qi Xiao-Qiang Wang Shu-Ting Pan Pei-Ying Li Ling-Ke Chen Qiang Xia Li-Qun Yang Wei-Feng Yu Source Type: research

Could saline irrigation clear all residual common bile duct stones after lithotripsy? A self-controlled prospective cohort study
CONCLUSION: Irrigation with 100 mL of saline may not clear all residual CBD stones after lithotripsy, especially in patients with PAD and/or a dilated (> 15 mm) CBD. Pigment residual stones are soft and commonly found in patients with PAD. Additional saline irrigation may be required to remove retained stones.PMID:33584068 | PMC:PMC7852583 | DOI:10.3748/wjg.v27.i4.358 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Yan-Yan Lin Yu-Dong Wang Ping Yue Xian-Zhuo Zhang Joseph W Leung Pan-Pan Jiao Man Yang Hai-Ping Wang Bing Bai Ying Liu Jin-Duo Zhang Hong-Bo Chen Wen-Bo Meng Xun Li Source Type: research

Duplication of the common bile duct manifesting as recurrent pyogenic cholangitis: A case report
CONCLUSION: In this article, we report an extremely rare case of DCBD manifesting as recurrent pyogenic cholangitis. This case highlights the importance of recognizing DCBD because stones in the unrecognized bile duct could make the patient's prognosis critical.PMID:33584069 | PMC:PMC7852585 | DOI:10.3748/wjg.v27.i4.371 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Jun Seong Hwang Sung Woo Ko Source Type: research

Liver injury in the era of COVID-19
World J Gastroenterol. 2021 Feb 7;27(5):377-390. doi: 10.3748/wjg.v27.i5.377.ABSTRACTSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has undoubtedly revolutionized the whole globe and given a new point of view on respiratory tract infections. Nevertheless, coronavirus disease 2019 (COVID-19) cannot be perceived as a disease limited only to pneumonia with diverse severity. More and more reports have demonstrated a wide range of possible systemic symptoms, including hepatic complications. Liver injury has been observed in a significant proportion of patients, especially in those with a severe or critical illness...
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Halina Cicho ż-Lach Agata Michalak Source Type: research

Changes in gut microbiota composition and diversity associated with post-cholecystectomy diarrhea
CONCLUSION: This study demonstrated that gut dysbiosis may play a critical role in PCD, which provides new insights into therapeutic options for PCD patients.PMID:33584071 | PMC:PMC7856843 | DOI:10.3748/wjg.v27.i5.391 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Yan-Dong Li Bao-Ning Liu Si-Hai Zhao Yong-Li Zhou Liang Bai En-Qi Liu Source Type: research

Histopathology and the predominantly progressive, indeterminate and predominately regressive score in hepatitis C virus patients after direct-acting antivirals therapy
CONCLUSION: Significant improvement of necroinflammation and partial remission of fibrosis in HCV patients occurred shortly after DAAs therapy. The P-I-R score has potential in predicting fibrosis in HCV patients.PMID:33584072 | PMC:PMC7856841 | DOI:10.3748/wjg.v27.i5.404 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Rui Huang Hui-Ying Rao Ming Yang Ying-Hui Gao Jian Wang Qian Jin Dan-Li Ma Lai Wei Source Type: research

Comparative study of indocyanine green-R15, Child-Pugh score, and model for end-stage liver disease score for prediction of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt
CONCLUSION: The ICG-R15 has appreciated clinical value for predicting the occurrence of post-TIPS HE and is a choice for evaluating the prognosis of patients undergoing TIPS.PMID:33584073 | PMC:PMC7856842 | DOI:10.3748/wjg.v27.i5.416 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Zhong Wang Yi-Fan Wu Zhen-Dong Yue Hong-Wei Zhao Lei Wang Zhen-Hua Fan Yu Zhang Fu-Quan Liu Source Type: research

Noninferiority clinical trial comparing the bowel cleansing efficacy of sodium phosphate tablets (Quiklean < sup > ® < /sup > ) with a polyethylene glycol/bisacodyl kit
World J Gastroenterol. 2021 Feb 7;27(5):428-441. doi: 10.3748/wjg.v27.i5.428.ABSTRACTBACKGROUND: Efficient bowel cleansing is essential for a successful colonoscopy, but the ideal cleansing agent, volume, and pharmaceutical dosage form have yet to be determined. Small-volume cleansers enhance patient compliance.AIM: To compare the bowel cleansing efficacy of 32-tablet sodium phosphate (Quiklean®) with 2-L polyethylene glycol (PEG)/bisacodyl (Klean-Prep/ Dulcolax®) under identical dietary recommendations.METHODS: This multicenter, randomized, parallel-group, noninferiority clinical trial enrolled 472 outpatients, ra...
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Shih-Ya Hung Hung-Chang Chen Tao-Wei Ke Jiann-Hwa Chen Koung-Hung Hsiao Hwei-Ming Wang Hua-Che Chiang Sheng-Chi Chang Yi-Chang Chen Ming-Hao Hsieh Yuan-Yao Tsai Yo-Wen Hsieh William Tzu-Liang Chen Source Type: research

Vedolizumab in Crohn's disease with rectal fistulas and presacral abscess: A case report
CONCLUSION: Early vedolizumab and stool diversion are effective and safe in treating CD with complex rectal fistula with abscess formation.PMID:33584075 | PMC:PMC7856844 | DOI:10.3748/wjg.v27.i5.442 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Heng Yeh Chia-Jung Kuo Ren-Chin Wu Chien-Ming Chen Wen-Sy Tsai Ming-Yao Su Cheng-Tang Chiu Puo-Hsien Le Source Type: research

Pleiotropy within gene variants associated with nonalcoholic fatty liver disease and traits of the hematopoietic system
World J Gastroenterol. 2021 Jan 28;27(4):305-320. doi: 10.3748/wjg.v27.i4.305.ABSTRACTGenome-wide association studies of complex diseases, including nonalcoholic fatty liver disease (NAFLD), have demonstrated that a large number of variants are implicated in the susceptibility of multiple traits - a phenomenon known as pleiotropy that is increasingly being explored through phenome-wide association studies. We focused on the analysis of pleiotropy within variants associated with hematologic traits and NAFLD. We used information retrieved from large public National Health and Nutrition Examination Surveys, Genome-wide associ...
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Carlos Jose Pirola Adrian Salatino Silvia Sookoian Source Type: research

Preoperative maximal voluntary ventilation, hemoglobin, albumin, lymphocytes and platelets predict postoperative survival in esophageal squamous cell carcinoma
World J Gastroenterol. 2021 Jan 28;27(4):321-335. doi: 10.3748/wjg.v27.i4.321.ABSTRACTBACKGROUND: Preoperative pulmonary function plays an important role in selecting surgical candidates and assessing postoperative complications. Reduced pulmonary function is associated with poor survival in several cancers, but the prognostic value of preoperative pulmonary function in esophageal squamous cell carcinoma (ESCC) is unclear. Nutritional and systemic inflammation parameters are vital to cancer survival, and the combination of these parameters improves the prognostic value. The hemoglobin, albumin, lymphocytes and platelets (H...
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Shou-Jia Hu Xue-Ke Zhao Xin Song Ling-Ling Lei Wen-Li Han Rui-Hua Xu Ran Wang Fu-You Zhou Liang Wang Li-Dong Wang Source Type: research

Clinic-pathological features of metabolic associated fatty liver disease with hepatitis B virus infection
World J Gastroenterol. 2021 Jan 28;27(4):336-344. doi: 10.3748/wjg.v27.i4.336.ABSTRACTBACKGROUND: Metabolic associated fatty liver disease (MAFLD) is a novel concept proposed in 2020.AIM: To compare the characteristics of MAFLD and MAFLD with hepatitis B virus (HBV) infection.METHODS: Patients with histopathologically proven MAFLD from a single medical center were included. Patients were divided into MAFLD group (without HBV infection) and HBV-MAFLD group (with HBV infection). Propensity score matching was utilized to balance the baseline characteristics between two groups.RESULTS: A total of 417 cases with MAFLD were incl...
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Ming-Fang Wang Bo Wan Yin-Lian Wu Jiao-Feng Huang Yue-Yong Zhu You-Bing Li Source Type: research

Effect of remote ischemic preconditioning among donors and recipients following pediatric liver transplantation: A randomized clinical trial
World J Gastroenterol. 2021 Jan 28;27(4):345-357. doi: 10.3748/wjg.v27.i4.345.ABSTRACTBACKGROUND: Studies suggested that remote ischemic preconditioning (RIPC) may effectively lessen the harmful effects of ischemia reperfusion injury during organ transplantation surgery.AIM: To investigate the protective effects of RIPC on living liver donors and recipients following pediatric liver transplantation.METHODS: From January 2016 to January 2019 at Renji Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, 208 donors were recruited and randomly assigned to four groups: S-RIPC group (no intervention; n = 55...
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Bo Qi Xiao-Qiang Wang Shu-Ting Pan Pei-Ying Li Ling-Ke Chen Qiang Xia Li-Qun Yang Wei-Feng Yu Source Type: research

Could saline irrigation clear all residual common bile duct stones after lithotripsy? A self-controlled prospective cohort study
CONCLUSION: Irrigation with 100 mL of saline may not clear all residual CBD stones after lithotripsy, especially in patients with PAD and/or a dilated (> 15 mm) CBD. Pigment residual stones are soft and commonly found in patients with PAD. Additional saline irrigation may be required to remove retained stones.PMID:33584068 | PMC:PMC7852583 | DOI:10.3748/wjg.v27.i4.358 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Yan-Yan Lin Yu-Dong Wang Ping Yue Xian-Zhuo Zhang Joseph W Leung Pan-Pan Jiao Man Yang Hai-Ping Wang Bing Bai Ying Liu Jin-Duo Zhang Hong-Bo Chen Wen-Bo Meng Xun Li Source Type: research

Duplication of the common bile duct manifesting as recurrent pyogenic cholangitis: A case report
CONCLUSION: In this article, we report an extremely rare case of DCBD manifesting as recurrent pyogenic cholangitis. This case highlights the importance of recognizing DCBD because stones in the unrecognized bile duct could make the patient's prognosis critical.PMID:33584069 | PMC:PMC7852585 | DOI:10.3748/wjg.v27.i4.371 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Jun Seong Hwang Sung Woo Ko Source Type: research

Liver injury in the era of COVID-19
World J Gastroenterol. 2021 Feb 7;27(5):377-390. doi: 10.3748/wjg.v27.i5.377.ABSTRACTSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has undoubtedly revolutionized the whole globe and given a new point of view on respiratory tract infections. Nevertheless, coronavirus disease 2019 (COVID-19) cannot be perceived as a disease limited only to pneumonia with diverse severity. More and more reports have demonstrated a wide range of possible systemic symptoms, including hepatic complications. Liver injury has been observed in a significant proportion of patients, especially in those with a severe or critical illness...
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Halina Cicho ż-Lach Agata Michalak Source Type: research

Changes in gut microbiota composition and diversity associated with post-cholecystectomy diarrhea
CONCLUSION: This study demonstrated that gut dysbiosis may play a critical role in PCD, which provides new insights into therapeutic options for PCD patients.PMID:33584071 | PMC:PMC7856843 | DOI:10.3748/wjg.v27.i5.391 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Yan-Dong Li Bao-Ning Liu Si-Hai Zhao Yong-Li Zhou Liang Bai En-Qi Liu Source Type: research

Histopathology and the predominantly progressive, indeterminate and predominately regressive score in hepatitis C virus patients after direct-acting antivirals therapy
CONCLUSION: Significant improvement of necroinflammation and partial remission of fibrosis in HCV patients occurred shortly after DAAs therapy. The P-I-R score has potential in predicting fibrosis in HCV patients.PMID:33584072 | PMC:PMC7856841 | DOI:10.3748/wjg.v27.i5.404 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Rui Huang Hui-Ying Rao Ming Yang Ying-Hui Gao Jian Wang Qian Jin Dan-Li Ma Lai Wei Source Type: research

Comparative study of indocyanine green-R15, Child-Pugh score, and model for end-stage liver disease score for prediction of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt
CONCLUSION: The ICG-R15 has appreciated clinical value for predicting the occurrence of post-TIPS HE and is a choice for evaluating the prognosis of patients undergoing TIPS.PMID:33584073 | PMC:PMC7856842 | DOI:10.3748/wjg.v27.i5.416 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Zhong Wang Yi-Fan Wu Zhen-Dong Yue Hong-Wei Zhao Lei Wang Zhen-Hua Fan Yu Zhang Fu-Quan Liu Source Type: research

Noninferiority clinical trial comparing the bowel cleansing efficacy of sodium phosphate tablets (Quiklean < sup > ® < /sup > ) with a polyethylene glycol/bisacodyl kit
World J Gastroenterol. 2021 Feb 7;27(5):428-441. doi: 10.3748/wjg.v27.i5.428.ABSTRACTBACKGROUND: Efficient bowel cleansing is essential for a successful colonoscopy, but the ideal cleansing agent, volume, and pharmaceutical dosage form have yet to be determined. Small-volume cleansers enhance patient compliance.AIM: To compare the bowel cleansing efficacy of 32-tablet sodium phosphate (Quiklean®) with 2-L polyethylene glycol (PEG)/bisacodyl (Klean-Prep/ Dulcolax®) under identical dietary recommendations.METHODS: This multicenter, randomized, parallel-group, noninferiority clinical trial enrolled 472 outpatients, ra...
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Shih-Ya Hung Hung-Chang Chen Tao-Wei Ke Jiann-Hwa Chen Koung-Hung Hsiao Hwei-Ming Wang Hua-Che Chiang Sheng-Chi Chang Yi-Chang Chen Ming-Hao Hsieh Yuan-Yao Tsai Yo-Wen Hsieh William Tzu-Liang Chen Source Type: research