Artificial intelligence in gastroenterology and hepatology: Status and challenges
World J Gastroenterol. 2021 Apr 28;27(16):1664-1690. doi: 10.3748/wjg.v27.i16.1664.ABSTRACTOriginally proposed by John McCarthy in 1955, artificial intelligence (AI) has achieved a breakthrough and revolutionized the processing methods of clinical medicine with the increasing workloads of medical records and digital images. Doctors are paying attention to AI technologies for various diseases in the fields of gastroenterology and hepatology. This review will illustrate AI technology procedures for medical image analysis, including data processing, model establishment, and model validation. Furthermore, we will summarize AI ...
Source: World Journal of Gastroenterology : WJG - May 10, 2021 Category: Gastroenterology Authors: Jia-Sheng Cao Zi-Yi Lu Ming-Yu Chen Bin Zhang Sarun Juengpanich Jia-Hao Hu Shi-Jie Li Win Topatana Xue-Yin Zhou Xu Feng Ji-Liang Shen Yu Liu Xiu-Jun Cai Source Type: research

From hepatitis A to E: A critical review of viral hepatitis
World J Gastroenterol. 2021 Apr 28;27(16):1691-1715. doi: 10.3748/wjg.v27.i16.1691.ABSTRACTViral infections affecting the liver have had an important impact on humanity, as they have led to significant morbidity and mortality in patients with acute and chronic infections. Once an unknown etiology, the discovery of the viral agents triggered interest of the scientific community to establish the pathogenesis and diagnostic modalities to identify the affected population. With the rapid scientific and technological advances in the last centuries, controlling and even curing the infections became a possibility, with a large foc...
Source: World Journal of Gastroenterology : WJG - May 10, 2021 Category: Gastroenterology Authors: Daniel Castaneda Adalberto Jose Gonzalez Mohammad Alomari Kanwarpreet Tandon Xaralambos Bobby Zervos Source Type: research

Paediatric gastrointestinal disorders in SARS-CoV-2 infection: Epidemiological and clinical implications
World J Gastroenterol. 2021 Apr 28;27(16):1716-1727. doi: 10.3748/wjg.v27.i16.1716.ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic is a threat worldwide for individuals of all ages, including children. Gastrointestinal manifestations could be the initial presenting manifestation in many patients, especially in children. These symptoms are more common in patients with severe disease than in patients with non-severe disease. Approximately 48.1% of patients had a stool sample that was positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral RNA. Children typically form 1%-8% of all laboratory-c...
Source: World Journal of Gastroenterology : WJG - May 10, 2021 Category: Gastroenterology Authors: Mohammed Al-Beltagi Nermin Kamal Saeed Adel Salah Bediwy Yasser El-Sawaf Source Type: research

Hepatitis C virus micro-elimination: Where do we stand?
World J Gastroenterol. 2021 Apr 28;27(16):1728-1737. doi: 10.3748/wjg.v27.i16.1728.ABSTRACTHepatitis C virus (HCV) elimination by 2030, using direct-acting antiviral treatments, has been promoted by the World Health Organization. This achievement is not attainable, however, particularly after the 2020 pandemic of the coronavirus disease 2019. Consequently, the more realistic objective of eliminating HCV from population segments for which targeted strategies of prevention and treatment are easily attained has been promoted in Europe, as a valid alternative. The underlying idea is that micro-elimination will ultimately lead ...
Source: World Journal of Gastroenterology : WJG - May 10, 2021 Category: Gastroenterology Authors: Alessandra Mangia Rosa Cotugno Giovanna Cocomazzi Maria Maddalena Squillante Valeria Piazzolla Source Type: research

Coronavirus disease 2019 severity in obesity: Metabolic dysfunction-associated fatty liver disease in the spotlight
In conclusion, MAFLD represents a higher risk than obesity for COVID-19 severity, resulting in poor outcomes and even progression to non-alcoholic steatohepatitis. Hepatologists should include MAFLD subjects in the high-risk group, intensify preventive measurements, and prioritize their vaccination.PMID:33967554 | PMC:PMC8072197 | DOI:10.3748/wjg.v27.i16.1738 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 10, 2021 Category: Gastroenterology Authors: Isabela Macedo Lopes Vasques-Monteiro Vanessa Souza-Mello Source Type: research

Preoperative physiological esophageal assessment for anti-reflux surgery: A guide for surgeons on high-resolution manometry and pH testing
World J Gastroenterol. 2021 Apr 28;27(16):1751-1769. doi: 10.3748/wjg.v27.i16.1751.ABSTRACTGastroesophageal reflux disease (GERD) is one of the most commonly encountered digestive diseases in the world, with the prevalence continuing to increase. Many patients are successfully treated with lifestyle modifications and proton pump inhibitor therapy, but a subset of patients require more aggressive intervention for control of their symptoms. Surgical treatment with fundoplication is a viable option for patients with GERD, as it attempts to improve the integrity of the lower esophageal sphincter (LES). While surgery can be as ...
Source: World Journal of Gastroenterology : WJG - May 10, 2021 Category: Gastroenterology Authors: Michael Yodice Alexandra Mignucci Virali Shah Christopher Ashley Micheal Tadros Source Type: research

Protective effect and mechanisms of action of Mongolian medicine Sulongga-4 on pyloric ligation-induced gastroduodenal ulcer in rats
World J Gastroenterol. 2021 Apr 28;27(16):1770-1784. doi: 10.3748/wjg.v27.i16.1770.ABSTRACTBACKGROUND: Sulongga-4 (SL-4) is a herbal formula used in traditional Mongolian medical clinics for the treatment of peptic ulcers and gastroenteritis, even though its pharmacological mechanism has not been well characterized.AIM: To evaluate the protective effect and identify the mechanisms of action of SL-4 on gastroduodenal ulcer induced by pyloric ligation (PL) in rats.METHODS: PL was performed to induce gastric and duodenal ulcers in rats, which were then treated with oral SL-4 (1.3, 2.6, or 3.9 g/kg per day) for 15 d. PL-induce...
Source: World Journal of Gastroenterology : WJG - May 10, 2021 Category: Gastroenterology Authors: Shan Tong Huan Wang Li-Sha A Ta-Na Bai Ju-Hua Gong Wen-Jie Jin Li-Li Dai Gen-Na Ba Sung-Bo Cho Ming-Hai Fu Source Type: research

Depletion of MRPL35 inhibits gastric carcinoma cell proliferation by regulating downstream signaling proteins
CONCLUSION: Collectively, our findings demonstrate that knockdown of MRPL35 inhibits GC cell proliferation through related proteins including PICK1, BCL-XL, and AGR2.PMID:33967557 | PMC:PMC8072187 | DOI:10.3748/wjg.v27.i16.1785 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 10, 2021 Category: Gastroenterology Authors: Ling Yuan Jia-Xin Li Yi Yang Yan Chen Ting-Ting Ma Shuang Liang Yang Bu Lei Yu Yi Nan Source Type: research

Mitochondrial pathway of the lysine demethylase 5C inhibitor CPI-455 in the Eca-109 esophageal squamous cell carcinoma cell line
CONCLUSION: CPI-455 inhibited Eca-109 cell proliferation via mitochondrial apoptosis by regulating the expression of related genes.PMID:33967558 | PMC:PMC8072195 | DOI:10.3748/wjg.v27.i16.1805 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 10, 2021 Category: Gastroenterology Authors: Xiao-Jie Xue Fei-Rong Li Jing Yu Source Type: research

Health-related quality of life after curative resection for gastric adenocarcinoma
CONCLUSION: Based on our results, Roux-en-Y reconstruction after subtotal distal gastrectomy should be preferred over Billroth II reconstruction. The data obtained from this study will help surgeons when preoperatively informing their patients about expected functional outcomes after gastrectomy and enable them to ensure proper supportive care of their patients in the postoperative period.PMID:33967559 | PMC:PMC8072188 | DOI:10.3748/wjg.v27.i16.1816 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 10, 2021 Category: Gastroenterology Authors: Jan Grosek Hana Zavrtanik Ale š Tomažič Source Type: research

Surrogate markers of mucosal healing in inflammatory bowel disease: A systematic review
CONCLUSION: Several promising biomarkers of MH are emerging but cannot yet substitute for endoscopy with biopsy due to issues with reproducibility and standardization.PMID:33967560 | PMC:PMC8072191 | DOI:10.3748/wjg.v27.i16.1828 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 10, 2021 Category: Gastroenterology Authors: Monica State Lucian Negreanu Theodor Voiosu Andrei Voiosu Paul Balanescu Radu Bogdan Mateescu Source Type: research

Managing esophagocutaneous fistula after secondary gastric pull-up: A case report
CONCLUSION: A multidisciplinary approach involving interventional endoscopists and surgeons successfully managed severe complications arising from a cervical esophagocutaneous fistula after GPU. Endoscopic treatment may have lowered the perioperative risk to promote primary wound healing after free-jejunal graft interposition.PMID:33967561 | PMC:PMC8072190 | DOI:10.3748/wjg.v27.i16.1841 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 10, 2021 Category: Gastroenterology Authors: Johan F Lock Stanislaus Reimer Sebastian Pietryga Rafael Jakubietz Sven Flemming Alexander Meining Christoph-Thomas Germer Florian Seyfried Source Type: research

Textbook outcomes in hepatobiliary and pancreatic surgery
World J Gastroenterol. 2021 Apr 21;27(15):1524-1530. doi: 10.3748/wjg.v27.i15.1524.ABSTRACTThe concept of textbook outcome (TO) has recently gained popularity in surgical research and has been used to evaluate the quality or success of different surgical procedures, including hepatopancreatobiliary (HPB) operations. TO consists of individual outcome parameters that each reflect different domains of care including structure, process, and individual outcomes; in turn, the composite TO metric represents the optimal course after a surgical episode. TO can be used to assess patient-level outcomes, hospital performance, center d...
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Diamantis I Tsilimigras Timothy Michael Pawlik Dimitrios Moris Source Type: research

Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2: Prospective therapeutic challenges
World J Gastroenterol. 2021 Apr 21;27(15):1531-1552. doi: 10.3748/wjg.v27.i15.1531.ABSTRACTCoronavirus disease 2019 (COVID-19) is a devastating worldwide pandemic infection caused by a severe acute respiratory syndrome namely coronavirus 2 (SARS-CoV-2) that is associated with a high spreading and mortality rate. On the date this review was written, SARS-CoV-2 infected about 96 million people and killed about 2 million people. Several arguments disclosed the high mortality of COVID-19 due to acute respiratory distress syndrome or change in the amount of angiotensin-converting enzyme 2 (ACE2) receptor expression or cytokine ...
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Fares E M Ali Zuhair M Mohammedsaleh Mahmoud M Ali Osama M Ghogar Source Type: research

Diagnostic approach to faecal incontinence: What test and when to perform?
World J Gastroenterol. 2021 Apr 21;27(15):1553-1562. doi: 10.3748/wjg.v27.i15.1553.ABSTRACTFaecal incontinence (FI) is a debilitating common end result of several diseases affecting the quality of life and leading to patient disability, morbidity, and increased societal burden. Given the various causes of FI, it is important to assess and identify the underlying pathomechanisms. Several investigatory tools are available including high-resolution anorectal manometry, transrectal ultrasound, magnetic resonance imaging, and electromyography. This review article provides an overview on the causes and pathophysiology of FI and ...
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Wisam Sbeit Tawfik Khoury Amir Mari Source Type: research

Prevention of late complications with coverage agents in endoscopic resection of colorectal lesions: Current landscape in gastrointestinal endoscopy
World J Gastroenterol. 2021 Apr 21;27(15):1563-1568. doi: 10.3748/wjg.v27.i15.1563.ABSTRACTEndoscopic removal of large (≥ 20 mm) non-pedunculated colorectal lesions (LNPCLs) may result in major adverse events, such as delayed bleeding (DB) and delayed perforation (DP), despite closure of the mucosal defects with clips. Topical application of a coverage agent refers to the creation of a shield with a biocompatible medical device (tissue or hydrogel) with proven bioactive properties. Coverage of the eschar after endoscopic resection provides shielding protection to prevent delayed complications. The aim of the present rev...
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Vicente Lorenzo-Z úñiga Marco Bustamante-Bal én Vicente Pons-Beltr án Source Type: research

Current status of diagnosis and therapy for intraductal papillary neoplasm of the bile duct
World J Gastroenterol. 2021 Apr 21;27(15):1569-1577. doi: 10.3748/wjg.v27.i15.1569.ABSTRACTBile duct epithelial tumours showing papillary neoplasm in the bile duct lumen are present in the intrahepatic and extrahepatic bile ducts. Clinicopathological images of these tumours are distinctive and diverse, including histological images with a low to high grade dysplasia, infiltrating and noninfiltrating characteristics, excessive mucus production, and similarity to intraductal papillary mucinous neoplasm (IPMN) of the pancreas. The World Health Organization Classification of Tumours of the Digestive System in 2010 named these ...
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Yuji Sakai Masayuki Ohtsuka Harutoshi Sugiyama Rintaro Mikata Shin Yasui Izumi Ohno Yotaro Iino Jun Kato Toshio Tsuyuguchi Naoya Kato Source Type: research

Leucine-rich repeat-containing G protein-coupled receptor 5 marks different cancer stem cell compartments in human Caco-2 and LoVo colon cancer lines
CONCLUSION: Our findings highlight the presence of a spectrum of different ISC-like compartments in different colon cancer cell lines. Their existence is an important consideration for their screening applications and should be taken into account when interpreting drug screening data. We have generated a portable LGR5-reporter that serves as a valuable tool for the identification and isolation of different colon cancer stem cell populations in colon cancer lines.PMID:33958845 | PMC:PMC8058648 | DOI:10.3748/wjg.v27.i15.1578 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Samah Abdulaali Alharbi Dmitry A Ovchinnikov Ernst Wolvetang Source Type: research

Abelson interactor 1 splice isoform-L plays an anti-oncogenic role in colorectal carcinoma through interactions with WAVE2 and full-length Abelson interactor 1
CONCLUSION: These results support a model in which ABI1-SiL plays an anti-oncogenic role by competitively binding to WAVE2 and directly interacting with phosphorylated and non-phosphorylated ABI1-p65, functioning as a dominant-negative form of ABI1-p65.PMID:33958846 | PMC:PMC8058658 | DOI:10.3748/wjg.v27.i15.1595 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Kun Li Yi-Fan Peng Jing-Zhu Guo Mei Li Yu Zhang Jing-Yi Chen Ting-Ru Lin Xin Yu Wei-Dong Yu Source Type: research

Effects of CXCL12 isoforms in a pancreatic pre-tumour cellular model: Microarray analysis
CONCLUSION: Our data suggests an involvement and different roles of CXCL12 isoforms in PDAC onset. However, more investigations are needed to confirm these preliminary observations.PMID:33958847 | PMC:PMC8058651 | DOI:10.3748/wjg.v27.i15.1616 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Monia Cecati Matteo Giulietti Alessandra Righetti Berina Sabanovic Francesco Piva Source Type: research

Resection of pancreatic cystic neoplasms in recurrent acute pancreatitis prevents recurrent pancreatitis but does not identify more malignancies
World J Gastroenterol. 2021 Apr 21;27(15):1630-1642. doi: 10.3748/wjg.v27.i15.1630.ABSTRACTBACKGROUND: Recurrent acute pancreatitis (RAP) may be a presenting feature of and an indication for resection of pancreatic cysts, including intra-ductal papillary mucinous neoplasm (IPMN). Few data are available regarding the prevalence of malignancy and post-operative RAP in this population.AIM: To study the role of resection to help prevent RAP and analyze if presentation as RAP would be a predictor for malignancy.METHODS: This retrospective study assessed 172 patients who underwent surgical resection of pancreatic cystic neoplasm...
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Thiruvengadam Muniraj Harry R Aslanian Loren Laine Priya A Jamidar James F Farrell Kisha A Mitchell Ronald R Salem Source Type: research

Intestinal bacterial overgrowth in the early stage of severe acute pancreatitis is associated with acute respiratory distress syndrome
CONCLUSION: Intestinal bacterial overgrowth in the early stage of SAP is correlated with ARDS.PMID:33958849 | PMC:PMC8058650 | DOI:10.3748/wjg.v27.i15.1643 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Xue-Ying Liang Tian-Xu Jia Mei Zhang Source Type: research

Gastrointestinal cytomegalovirus disease secondary to measles in an immunocompetent infant: A case report
CONCLUSION: Extensive gastrointestinal CMV lesions can be induced by the immune suppression secondary to measles infection. Rational, fast, and effective laboratory examinations are essential for suspected patients.PMID:33958850 | PMC:PMC8058656 | DOI:10.3748/wjg.v27.i15.1655 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Qing-Hua Yang Xiao-Peng Ma Dong-Ling Dai Da-Ming Bai Yu Zou Si-Xi Liu Jian-Ming Song Source Type: research

Textbook outcomes in hepatobiliary and pancreatic surgery
World J Gastroenterol. 2021 Apr 21;27(15):1524-1530. doi: 10.3748/wjg.v27.i15.1524.ABSTRACTThe concept of textbook outcome (TO) has recently gained popularity in surgical research and has been used to evaluate the quality or success of different surgical procedures, including hepatopancreatobiliary (HPB) operations. TO consists of individual outcome parameters that each reflect different domains of care including structure, process, and individual outcomes; in turn, the composite TO metric represents the optimal course after a surgical episode. TO can be used to assess patient-level outcomes, hospital performance, center d...
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Diamantis I Tsilimigras Timothy Michael Pawlik Dimitrios Moris Source Type: research

Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2: Prospective therapeutic challenges
World J Gastroenterol. 2021 Apr 21;27(15):1531-1552. doi: 10.3748/wjg.v27.i15.1531.ABSTRACTCoronavirus disease 2019 (COVID-19) is a devastating worldwide pandemic infection caused by a severe acute respiratory syndrome namely coronavirus 2 (SARS-CoV-2) that is associated with a high spreading and mortality rate. On the date this review was written, SARS-CoV-2 infected about 96 million people and killed about 2 million people. Several arguments disclosed the high mortality of COVID-19 due to acute respiratory distress syndrome or change in the amount of angiotensin-converting enzyme 2 (ACE2) receptor expression or cytokine ...
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Fares E M Ali Zuhair M Mohammedsaleh Mahmoud M Ali Osama M Ghogar Source Type: research

Diagnostic approach to faecal incontinence: What test and when to perform?
World J Gastroenterol. 2021 Apr 21;27(15):1553-1562. doi: 10.3748/wjg.v27.i15.1553.ABSTRACTFaecal incontinence (FI) is a debilitating common end result of several diseases affecting the quality of life and leading to patient disability, morbidity, and increased societal burden. Given the various causes of FI, it is important to assess and identify the underlying pathomechanisms. Several investigatory tools are available including high-resolution anorectal manometry, transrectal ultrasound, magnetic resonance imaging, and electromyography. This review article provides an overview on the causes and pathophysiology of FI and ...
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Wisam Sbeit Tawfik Khoury Amir Mari Source Type: research

Prevention of late complications with coverage agents in endoscopic resection of colorectal lesions: Current landscape in gastrointestinal endoscopy
World J Gastroenterol. 2021 Apr 21;27(15):1563-1568. doi: 10.3748/wjg.v27.i15.1563.ABSTRACTEndoscopic removal of large (≥ 20 mm) non-pedunculated colorectal lesions (LNPCLs) may result in major adverse events, such as delayed bleeding (DB) and delayed perforation (DP), despite closure of the mucosal defects with clips. Topical application of a coverage agent refers to the creation of a shield with a biocompatible medical device (tissue or hydrogel) with proven bioactive properties. Coverage of the eschar after endoscopic resection provides shielding protection to prevent delayed complications. The aim of the present rev...
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Vicente Lorenzo-Z úñiga Marco Bustamante-Bal én Vicente Pons-Beltr án Source Type: research

Current status of diagnosis and therapy for intraductal papillary neoplasm of the bile duct
World J Gastroenterol. 2021 Apr 21;27(15):1569-1577. doi: 10.3748/wjg.v27.i15.1569.ABSTRACTBile duct epithelial tumours showing papillary neoplasm in the bile duct lumen are present in the intrahepatic and extrahepatic bile ducts. Clinicopathological images of these tumours are distinctive and diverse, including histological images with a low to high grade dysplasia, infiltrating and noninfiltrating characteristics, excessive mucus production, and similarity to intraductal papillary mucinous neoplasm (IPMN) of the pancreas. The World Health Organization Classification of Tumours of the Digestive System in 2010 named these ...
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Yuji Sakai Masayuki Ohtsuka Harutoshi Sugiyama Rintaro Mikata Shin Yasui Izumi Ohno Yotaro Iino Jun Kato Toshio Tsuyuguchi Naoya Kato Source Type: research

Leucine-rich repeat-containing G protein-coupled receptor 5 marks different cancer stem cell compartments in human Caco-2 and LoVo colon cancer lines
CONCLUSION: Our findings highlight the presence of a spectrum of different ISC-like compartments in different colon cancer cell lines. Their existence is an important consideration for their screening applications and should be taken into account when interpreting drug screening data. We have generated a portable LGR5-reporter that serves as a valuable tool for the identification and isolation of different colon cancer stem cell populations in colon cancer lines.PMID:33958845 | PMC:PMC8058648 | DOI:10.3748/wjg.v27.i15.1578 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Samah Abdulaali Alharbi Dmitry A Ovchinnikov Ernst Wolvetang Source Type: research

Abelson interactor 1 splice isoform-L plays an anti-oncogenic role in colorectal carcinoma through interactions with WAVE2 and full-length Abelson interactor 1
CONCLUSION: These results support a model in which ABI1-SiL plays an anti-oncogenic role by competitively binding to WAVE2 and directly interacting with phosphorylated and non-phosphorylated ABI1-p65, functioning as a dominant-negative form of ABI1-p65.PMID:33958846 | PMC:PMC8058658 | DOI:10.3748/wjg.v27.i15.1595 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Kun Li Yi-Fan Peng Jing-Zhu Guo Mei Li Yu Zhang Jing-Yi Chen Ting-Ru Lin Xin Yu Wei-Dong Yu Source Type: research

Effects of CXCL12 isoforms in a pancreatic pre-tumour cellular model: Microarray analysis
CONCLUSION: Our data suggests an involvement and different roles of CXCL12 isoforms in PDAC onset. However, more investigations are needed to confirm these preliminary observations.PMID:33958847 | PMC:PMC8058651 | DOI:10.3748/wjg.v27.i15.1616 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Monia Cecati Matteo Giulietti Alessandra Righetti Berina Sabanovic Francesco Piva Source Type: research

Resection of pancreatic cystic neoplasms in recurrent acute pancreatitis prevents recurrent pancreatitis but does not identify more malignancies
World J Gastroenterol. 2021 Apr 21;27(15):1630-1642. doi: 10.3748/wjg.v27.i15.1630.ABSTRACTBACKGROUND: Recurrent acute pancreatitis (RAP) may be a presenting feature of and an indication for resection of pancreatic cysts, including intra-ductal papillary mucinous neoplasm (IPMN). Few data are available regarding the prevalence of malignancy and post-operative RAP in this population.AIM: To study the role of resection to help prevent RAP and analyze if presentation as RAP would be a predictor for malignancy.METHODS: This retrospective study assessed 172 patients who underwent surgical resection of pancreatic cystic neoplasm...
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Thiruvengadam Muniraj Harry R Aslanian Loren Laine Priya A Jamidar James F Farrell Kisha A Mitchell Ronald R Salem Source Type: research

Intestinal bacterial overgrowth in the early stage of severe acute pancreatitis is associated with acute respiratory distress syndrome
CONCLUSION: Intestinal bacterial overgrowth in the early stage of SAP is correlated with ARDS.PMID:33958849 | PMC:PMC8058650 | DOI:10.3748/wjg.v27.i15.1643 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Xue-Ying Liang Tian-Xu Jia Mei Zhang Source Type: research

Gastrointestinal cytomegalovirus disease secondary to measles in an immunocompetent infant: A case report
CONCLUSION: Extensive gastrointestinal CMV lesions can be induced by the immune suppression secondary to measles infection. Rational, fast, and effective laboratory examinations are essential for suspected patients.PMID:33958850 | PMC:PMC8058656 | DOI:10.3748/wjg.v27.i15.1655 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Qing-Hua Yang Xiao-Peng Ma Dong-Ling Dai Da-Ming Bai Yu Zou Si-Xi Liu Jian-Ming Song Source Type: research

Textbook outcomes in hepatobiliary and pancreatic surgery
World J Gastroenterol. 2021 Apr 21;27(15):1524-1530. doi: 10.3748/wjg.v27.i15.1524.ABSTRACTThe concept of textbook outcome (TO) has recently gained popularity in surgical research and has been used to evaluate the quality or success of different surgical procedures, including hepatopancreatobiliary (HPB) operations. TO consists of individual outcome parameters that each reflect different domains of care including structure, process, and individual outcomes; in turn, the composite TO metric represents the optimal course after a surgical episode. TO can be used to assess patient-level outcomes, hospital performance, center d...
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Diamantis I Tsilimigras Timothy Michael Pawlik Dimitrios Moris Source Type: research

Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2: Prospective therapeutic challenges
World J Gastroenterol. 2021 Apr 21;27(15):1531-1552. doi: 10.3748/wjg.v27.i15.1531.ABSTRACTCoronavirus disease 2019 (COVID-19) is a devastating worldwide pandemic infection caused by a severe acute respiratory syndrome namely coronavirus 2 (SARS-CoV-2) that is associated with a high spreading and mortality rate. On the date this review was written, SARS-CoV-2 infected about 96 million people and killed about 2 million people. Several arguments disclosed the high mortality of COVID-19 due to acute respiratory distress syndrome or change in the amount of angiotensin-converting enzyme 2 (ACE2) receptor expression or cytokine ...
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Fares E M Ali Zuhair M Mohammedsaleh Mahmoud M Ali Osama M Ghogar Source Type: research

Diagnostic approach to faecal incontinence: What test and when to perform?
World J Gastroenterol. 2021 Apr 21;27(15):1553-1562. doi: 10.3748/wjg.v27.i15.1553.ABSTRACTFaecal incontinence (FI) is a debilitating common end result of several diseases affecting the quality of life and leading to patient disability, morbidity, and increased societal burden. Given the various causes of FI, it is important to assess and identify the underlying pathomechanisms. Several investigatory tools are available including high-resolution anorectal manometry, transrectal ultrasound, magnetic resonance imaging, and electromyography. This review article provides an overview on the causes and pathophysiology of FI and ...
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Wisam Sbeit Tawfik Khoury Amir Mari Source Type: research

Prevention of late complications with coverage agents in endoscopic resection of colorectal lesions: Current landscape in gastrointestinal endoscopy
World J Gastroenterol. 2021 Apr 21;27(15):1563-1568. doi: 10.3748/wjg.v27.i15.1563.ABSTRACTEndoscopic removal of large (≥ 20 mm) non-pedunculated colorectal lesions (LNPCLs) may result in major adverse events, such as delayed bleeding (DB) and delayed perforation (DP), despite closure of the mucosal defects with clips. Topical application of a coverage agent refers to the creation of a shield with a biocompatible medical device (tissue or hydrogel) with proven bioactive properties. Coverage of the eschar after endoscopic resection provides shielding protection to prevent delayed complications. The aim of the present rev...
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Vicente Lorenzo-Z úñiga Marco Bustamante-Bal én Vicente Pons-Beltr án Source Type: research

Current status of diagnosis and therapy for intraductal papillary neoplasm of the bile duct
World J Gastroenterol. 2021 Apr 21;27(15):1569-1577. doi: 10.3748/wjg.v27.i15.1569.ABSTRACTBile duct epithelial tumours showing papillary neoplasm in the bile duct lumen are present in the intrahepatic and extrahepatic bile ducts. Clinicopathological images of these tumours are distinctive and diverse, including histological images with a low to high grade dysplasia, infiltrating and noninfiltrating characteristics, excessive mucus production, and similarity to intraductal papillary mucinous neoplasm (IPMN) of the pancreas. The World Health Organization Classification of Tumours of the Digestive System in 2010 named these ...
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Yuji Sakai Masayuki Ohtsuka Harutoshi Sugiyama Rintaro Mikata Shin Yasui Izumi Ohno Yotaro Iino Jun Kato Toshio Tsuyuguchi Naoya Kato Source Type: research

Leucine-rich repeat-containing G protein-coupled receptor 5 marks different cancer stem cell compartments in human Caco-2 and LoVo colon cancer lines
CONCLUSION: Our findings highlight the presence of a spectrum of different ISC-like compartments in different colon cancer cell lines. Their existence is an important consideration for their screening applications and should be taken into account when interpreting drug screening data. We have generated a portable LGR5-reporter that serves as a valuable tool for the identification and isolation of different colon cancer stem cell populations in colon cancer lines.PMID:33958845 | PMC:PMC8058648 | DOI:10.3748/wjg.v27.i15.1578 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Samah Abdulaali Alharbi Dmitry A Ovchinnikov Ernst Wolvetang Source Type: research

Abelson interactor 1 splice isoform-L plays an anti-oncogenic role in colorectal carcinoma through interactions with WAVE2 and full-length Abelson interactor 1
CONCLUSION: These results support a model in which ABI1-SiL plays an anti-oncogenic role by competitively binding to WAVE2 and directly interacting with phosphorylated and non-phosphorylated ABI1-p65, functioning as a dominant-negative form of ABI1-p65.PMID:33958846 | PMC:PMC8058658 | DOI:10.3748/wjg.v27.i15.1595 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Kun Li Yi-Fan Peng Jing-Zhu Guo Mei Li Yu Zhang Jing-Yi Chen Ting-Ru Lin Xin Yu Wei-Dong Yu Source Type: research

Effects of CXCL12 isoforms in a pancreatic pre-tumour cellular model: Microarray analysis
CONCLUSION: Our data suggests an involvement and different roles of CXCL12 isoforms in PDAC onset. However, more investigations are needed to confirm these preliminary observations.PMID:33958847 | PMC:PMC8058651 | DOI:10.3748/wjg.v27.i15.1616 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Monia Cecati Matteo Giulietti Alessandra Righetti Berina Sabanovic Francesco Piva Source Type: research

Resection of pancreatic cystic neoplasms in recurrent acute pancreatitis prevents recurrent pancreatitis but does not identify more malignancies
World J Gastroenterol. 2021 Apr 21;27(15):1630-1642. doi: 10.3748/wjg.v27.i15.1630.ABSTRACTBACKGROUND: Recurrent acute pancreatitis (RAP) may be a presenting feature of and an indication for resection of pancreatic cysts, including intra-ductal papillary mucinous neoplasm (IPMN). Few data are available regarding the prevalence of malignancy and post-operative RAP in this population.AIM: To study the role of resection to help prevent RAP and analyze if presentation as RAP would be a predictor for malignancy.METHODS: This retrospective study assessed 172 patients who underwent surgical resection of pancreatic cystic neoplasm...
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Thiruvengadam Muniraj Harry R Aslanian Loren Laine Priya A Jamidar James F Farrell Kisha A Mitchell Ronald R Salem Source Type: research

Intestinal bacterial overgrowth in the early stage of severe acute pancreatitis is associated with acute respiratory distress syndrome
CONCLUSION: Intestinal bacterial overgrowth in the early stage of SAP is correlated with ARDS.PMID:33958849 | PMC:PMC8058650 | DOI:10.3748/wjg.v27.i15.1643 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Xue-Ying Liang Tian-Xu Jia Mei Zhang Source Type: research

Gastrointestinal cytomegalovirus disease secondary to measles in an immunocompetent infant: A case report
CONCLUSION: Extensive gastrointestinal CMV lesions can be induced by the immune suppression secondary to measles infection. Rational, fast, and effective laboratory examinations are essential for suspected patients.PMID:33958850 | PMC:PMC8058656 | DOI:10.3748/wjg.v27.i15.1655 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Qing-Hua Yang Xiao-Peng Ma Dong-Ling Dai Da-Ming Bai Yu Zou Si-Xi Liu Jian-Ming Song Source Type: research

Textbook outcomes in hepatobiliary and pancreatic surgery
World J Gastroenterol. 2021 Apr 21;27(15):1524-1530. doi: 10.3748/wjg.v27.i15.1524.ABSTRACTThe concept of textbook outcome (TO) has recently gained popularity in surgical research and has been used to evaluate the quality or success of different surgical procedures, including hepatopancreatobiliary (HPB) operations. TO consists of individual outcome parameters that each reflect different domains of care including structure, process, and individual outcomes; in turn, the composite TO metric represents the optimal course after a surgical episode. TO can be used to assess patient-level outcomes, hospital performance, center d...
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Diamantis I Tsilimigras Timothy Michael Pawlik Dimitrios Moris Source Type: research

Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2: Prospective therapeutic challenges
World J Gastroenterol. 2021 Apr 21;27(15):1531-1552. doi: 10.3748/wjg.v27.i15.1531.ABSTRACTCoronavirus disease 2019 (COVID-19) is a devastating worldwide pandemic infection caused by a severe acute respiratory syndrome namely coronavirus 2 (SARS-CoV-2) that is associated with a high spreading and mortality rate. On the date this review was written, SARS-CoV-2 infected about 96 million people and killed about 2 million people. Several arguments disclosed the high mortality of COVID-19 due to acute respiratory distress syndrome or change in the amount of angiotensin-converting enzyme 2 (ACE2) receptor expression or cytokine ...
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Fares E M Ali Zuhair M Mohammedsaleh Mahmoud M Ali Osama M Ghogar Source Type: research

Diagnostic approach to faecal incontinence: What test and when to perform?
World J Gastroenterol. 2021 Apr 21;27(15):1553-1562. doi: 10.3748/wjg.v27.i15.1553.ABSTRACTFaecal incontinence (FI) is a debilitating common end result of several diseases affecting the quality of life and leading to patient disability, morbidity, and increased societal burden. Given the various causes of FI, it is important to assess and identify the underlying pathomechanisms. Several investigatory tools are available including high-resolution anorectal manometry, transrectal ultrasound, magnetic resonance imaging, and electromyography. This review article provides an overview on the causes and pathophysiology of FI and ...
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Wisam Sbeit Tawfik Khoury Amir Mari Source Type: research

Prevention of late complications with coverage agents in endoscopic resection of colorectal lesions: Current landscape in gastrointestinal endoscopy
World J Gastroenterol. 2021 Apr 21;27(15):1563-1568. doi: 10.3748/wjg.v27.i15.1563.ABSTRACTEndoscopic removal of large (≥ 20 mm) non-pedunculated colorectal lesions (LNPCLs) may result in major adverse events, such as delayed bleeding (DB) and delayed perforation (DP), despite closure of the mucosal defects with clips. Topical application of a coverage agent refers to the creation of a shield with a biocompatible medical device (tissue or hydrogel) with proven bioactive properties. Coverage of the eschar after endoscopic resection provides shielding protection to prevent delayed complications. The aim of the present rev...
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Vicente Lorenzo-Z úñiga Marco Bustamante-Bal én Vicente Pons-Beltr án Source Type: research

Current status of diagnosis and therapy for intraductal papillary neoplasm of the bile duct
World J Gastroenterol. 2021 Apr 21;27(15):1569-1577. doi: 10.3748/wjg.v27.i15.1569.ABSTRACTBile duct epithelial tumours showing papillary neoplasm in the bile duct lumen are present in the intrahepatic and extrahepatic bile ducts. Clinicopathological images of these tumours are distinctive and diverse, including histological images with a low to high grade dysplasia, infiltrating and noninfiltrating characteristics, excessive mucus production, and similarity to intraductal papillary mucinous neoplasm (IPMN) of the pancreas. The World Health Organization Classification of Tumours of the Digestive System in 2010 named these ...
Source: World Journal of Gastroenterology : WJG - May 7, 2021 Category: Gastroenterology Authors: Yuji Sakai Masayuki Ohtsuka Harutoshi Sugiyama Rintaro Mikata Shin Yasui Izumi Ohno Yotaro Iino Jun Kato Toshio Tsuyuguchi Naoya Kato Source Type: research