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High throughput RNA sequencing utility for diagnosis and prognosis in colon diseases.
Abstract RNA sequencing is the use of high throughput next generation sequencing technology to survey, characterize, and quantify the transcriptome of a genome. RNA sequencing has been used to analyze the pathogenesis of several malignancies such melanoma, lung cancer, and colorectal cancer. RNA sequencing can identify differential expression of genes (DEG's), mutated genes, fusion genes, and gene isoforms in disease states. RNA sequencing has been used in the investigation of several colorectal diseases such as colorectal cancer, inflammatory bowel disease (ulcerative colitis and Crohn's disease), and irritable b...
Source: World Journal of Gastroenterology : WJG - April 28, 2017 Category: Gastroenterology Authors: Gao M, Zhong A, Patel N, Alur C, Vyas D Tags: World J Gastroenterol Source Type: research

Transition of early-phase treatment for acute pancreatitis: An analysis of nationwide epidemiological survey.
Abstract Treatment of acute pancreatitis (AP) is one of the critical challenges to the field of gastroenterology because of its high mortality rate and high medical costs associated with the treatment of severe cases. Early-phase treatments for AP have been optimized in Japan, and clinical guidelines have been provided. However, changes in early-phase treatments and the relationship between treatment strategy and clinical outcome remain unclear. Retrospective analysis of nationwide epidemiological data shows that time for AP diagnosis has shortened, and the amount of initial fluid resuscitation has increased over ...
Source: World Journal of Gastroenterology : WJG - April 28, 2017 Category: Gastroenterology Authors: Hamada S, Masamune A, Shimosegawa T Tags: World J Gastroenterol Source Type: research

Non-invasive evaluation of intestinal disorders: The role of elastographic techniques.
Abstract Over the recent years the non-invasive techniques for the evaluation of the small bowel have been playing a major role in the management of chronic intestinal diseases, such as inflammatory bowel diseases (IBD). The diagnostic performances of magnetic resonance imaging, computed tomography and ultrasound in the field of small bowel disorders, have been assessed and established for more than two decades. Newer sonographic techniques, such as strain elastography and shear wave elastography, have been put forward for the assessment of disease activity and characterization of IBD-related damage in the setting...
Source: World Journal of Gastroenterology : WJG - April 28, 2017 Category: Gastroenterology Authors: Branchi F, Caprioli F, Orlando S, Conte D, Fraquelli M Tags: World J Gastroenterol Source Type: research

Oxidative stress, antioxidants and intestinal calcium absorption.
Abstract The disequilibrium between the production of reactive oxygen (ROS) and nitrogen (RNS) species and their elimination by protective mechanisms leads to oxidative stress. Mitochondria are the main source of ROS as by-products of electron transport chain. Most of the time the intestine responds adequately against the oxidative stress, but with aging or under conditions that exacerbate the ROS and/or RNS production, the defenses are not enough and contribute to developing intestinal pathologies. The endogenous antioxidant defense system in gut includes glutathione (GSH) and GSH-dependent enzymes as major compo...
Source: World Journal of Gastroenterology : WJG - April 28, 2017 Category: Gastroenterology Authors: Diaz de Barboza G, Guizzardi S, Moine L, Tolosa de Talamoni N Tags: World J Gastroenterol Source Type: research

Importance of antimicrobial susceptibility testing for the management of eradication in Helicobacter pylori infection.
rbüz E Abstract The management of Helicobacter pylori (H. pylori) infection treatment differs from the common treatment protocol for other infectious diseases. Because culture- or molecular-guided approaches face several practical issues, such as the invasive procedures required to obtain gastric biopsy specimens and the lack of availability of routine laboratory testing in some places, H. pylori treatment includes the administration of two or three empirically selected antibiotics combined with a proton pump inhibitor rather than evidence-based eradication treatment. The efficacy of empirical therapy is decr...
Source: World Journal of Gastroenterology : WJG - April 28, 2017 Category: Gastroenterology Authors: Arslan N, Yılmaz Ö, Demiray-Gürbüz E Tags: World J Gastroenterol Source Type: research

Strategies used by helicobacter pylori to establish persistent infection.
Abstract Helicobacter pylori (H. pylori) is a Gram-negative and motile bacterium that colonizes the hostile microniche of the human stomach, then persists for the host's entire life, if not effectively treated. Clinically, H. pylori plays a causative role in the development of a wide spectrum of diseases including chronic active gastritis, peptic ulceration, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue lymphoma. Due to the global distribution of H. pylori, it is no exaggeration to conclude that smart strategies are contributing to adaptation of the bacterium to its permanent host. Thirty-f...
Source: World Journal of Gastroenterology : WJG - April 28, 2017 Category: Gastroenterology Authors: Abadi ATB Tags: World J Gastroenterol Source Type: research

Magnetic anchor guidance for endoscopic submucosal dissection and other endoscopic procedures.
Abstract Endoscopic submucosal dissection (ESD) is a well-established, minimally invasive treatment for superficial neoplasms of the gastrointestinal tract. The universal adoption of ESD has been limited by its slow learning curve, long procedure times, and high risk of complications. One technical challenge is the lack of a second hand that can provide traction, as in conventional surgery. Reliable tissue retraction that exposes the submucosal plane of dissection would allow for safer and more efficient dissection. Magnetic anchor guided endoscopic submucosal dissection (MAG-ESD) has potential benefits compared t...
Source: World Journal of Gastroenterology : WJG - April 28, 2017 Category: Gastroenterology Authors: Mortagy M, Mehta N, Parsi MA, Abe S, Stevens T, Vargo JJ, Saito Y, Bhatt A Tags: World J Gastroenterol Source Type: research

Droplet digital PCR for quantification of ITGA6 in a stool mRNA assay for the detection of colorectal cancers.
eu JF Abstract AIM: To investigate the use of droplet digital polymerase chain reaction (ddPCR) for detecting host mRNA markers in stools as a non-invasive test for colorectal cancer screening. METHODS: ddPCR and quantitative PCR were compared side by side for their performance in the detection of ITGA6 and ITGA6A transcripts in stool samples obtained from patients with various types of colorectal lesions (advanced adenomas and stage II-IV colorectal cancers) and control (patients displaying no pathological findings) using duplex TaqMan reactions for both methods. ITGA6 and ITGA6A were chosen for this proof-o...
Source: World Journal of Gastroenterology : WJG - April 28, 2017 Category: Gastroenterology Authors: Herring E, Kanaoka S, Tremblay É, Beaulieu JF Tags: World J Gastroenterol Source Type: research

Detection and characterization of murine colitis and carcinogenesis by molecularly targeted contrast-enhanced ultrasound.
worth D Abstract AIM: To study mucosal addressin cellular adhesion molecule-1 (MAdCAM-1) and vascular endothelial growth factor (VEGF)-targeted contrast enhanced ultrasound (CEUS) for the assessment of murine colitis and carcinogenesis. METHODS: C57BL/6 mice were challenged with 3% dextran sodium-sulfate (DSS) for three, six or nine days to study the development of acute colitis. Ultrasound was performed with and without the addition of unspecific contrast agents. MAdCAM-1-targeted contrast agent was used to detect and quantify MAdCAM-1 expression. Inflammatory driven colorectal azoxymethane (AOM)/DSS-induced...
Source: World Journal of Gastroenterology : WJG - April 28, 2017 Category: Gastroenterology Authors: Brückner M, Heidemann J, Nowacki TM, Cordes F, Stypmann J, Lenz P, Gohar F, Lügering A, Bettenworth D Tags: World J Gastroenterol Source Type: research

In vitro and in vivo antioxidative and hepatoprotective activity of aqueous extract of Cortex Dictamni.
Abstract AIM: To investigate the antioxidant and hepatoprotective effects of Cortex Dictamni aqueous extract (CDAE) in carbon tetrachloride (CCl4)-induced liver damage in rats. METHODS: The in vitro antioxidant effect of CDAE was investigated using α,α-diphenyl-β-picrylhydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), β-carotene bleaching, reducing power, and thiobarbituric acid reactive substance assays. A linoleic acid system, including ferric thiocyanate (FTC) and thiobarbituric acid (TBA) assays, was used to evaluate the inhibition of lipid peroxidation....
Source: World Journal of Gastroenterology : WJG - April 28, 2017 Category: Gastroenterology Authors: Li L, Zhou YF, Li YL, Wang LL, Arai H, Xu Y Tags: World J Gastroenterol Source Type: research

Comparison of the analgesic effects between electro-acupuncture and moxibustion with visceral hypersensitivity rats in irritable bowel syndrome.
Abstract AIM: To observe whether there are differences in the effects of electro-acupuncture (EA) and moxibustion (Mox) in rats with visceral hypersensitivity. METHODS: EA at 1 mA and 3 mA and Mox at 43 °C and 46 °C were applied to the Shangjuxu (ST37, bilateral) acupoints in model rats with visceral hypersensitivity. Responses of wide dynamic range neurons in dorsal horns of the spinal cord were observed through the extracellular recordings. Mast cells (MC) activity in the colons of rats were assessed, and 5-hydroxytryptamine (5-HT), 5-hydroxytryptamine 3 receptor (5-HT3R) and 5-HT4R expressions in t...
Source: World Journal of Gastroenterology : WJG - April 28, 2017 Category: Gastroenterology Authors: Zhao JM, Li L, Chen L, Shi Y, Li YW, Shang HX, Wu LY, Weng ZJ, Bao CH, Wu HG Tags: World J Gastroenterol Source Type: research

Study of the effects of nesfatin-1 on gastric function in obese rats.
CONCLUSION: Through this research, we provide a theoretical basis for further studies on nesfatin-1, a potential anti-obesity drug. PMID: 28522911 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2017 Category: Gastroenterology Authors: Yang GT, Zhao HY, Kong Y, Sun NN, Dong AQ Tags: World J Gastroenterol Source Type: research

Recent upper gastrointestinal panendoscopy increases the risk of pyogenic liver abscess.
CONCLUSION: An upper GI panendoscopy performed before 90 d may increase the risk of PLA. PMID: 28522912 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2017 Category: Gastroenterology Authors: Tsai MJ, Lu CL, Huang YC, Liu CH, Huang WT, Cheng KY, Chen SC Tags: World J Gastroenterol Source Type: research

Gutuo Jiejiu decoction improves survival of patients with severe alcoholic hepatitis: A retrospective cohort study.
Abstract AIM: To verify the value of Gutuo Jiejiu decoction in improving the survival of patients with severe alcoholic hepatitis (SAH). METHODS: We performed a retrospective cohort study in consecutive patients diagnosed with SAH at the Teaching Hospital of Chengdu University of Traditional Chinese Medicine and Shuguang Hospital, Shanghai University of Traditional Chinese Medicine. The traditional Chinese medicine formula Gutuo Jiejiu decoction was employed as an exposure factor. Patients from the Teaching Hospital of Chengdu University of Traditional Chinese Medicine who had been treated with Gutuo Jiejiu d...
Source: World Journal of Gastroenterology : WJG - April 28, 2017 Category: Gastroenterology Authors: Mou HY, Nie HM, Hu XY Tags: World J Gastroenterol Source Type: research

One year experience with computer-assisted propofol sedation for colonoscopy.
Abstract AIM: To report our one-year experience with computer assisted propofol sedation (CAPS) for colonoscopy as the first United States Medical Center to adopt CAPS technology for routine clinical use. METHODS: Between September 2014 and August 2015, 2677 patients underwent elective outpatient colonoscopy with CAPS at our center. All colonoscopies were performed by 1 of 17 gastroenterologists certified in the use of the CAPS system, with the assistance of a specially trained nurse. Procedural success rates, polyp detection rates, procedure times and recovery times were recorded and compared against corresp...
Source: World Journal of Gastroenterology : WJG - April 28, 2017 Category: Gastroenterology Authors: Lin OS, La Selva D, Kozarek RA, Tombs D, Weigel W, Beecher R, Koch J, McCormick S, Chiorean M, Drennan F, Gluck M, Venu N, Larsen M, Ross A Tags: World J Gastroenterol Source Type: research

Ninety-day readmissions after inpatient cholecystectomy: A 5-year analysis.
CONCLUSION: The use of 30-d cutoff point may underestimate the incidence of complications. The current tendency is to use 90 d as a limit to measure complications associated with any surgical procedure. PMID: 28522915 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2017 Category: Gastroenterology Authors: Manuel-Vázquez A, Latorre-Fragua R, Ramiro-Pérez C, López-Marcano A, Al-Shwely F, De la Plaza-Llamas R, Ramia JM Tags: World J Gastroenterol Source Type: research

Early hepatitis B viral DNA clearance predicts treatment response at week 96.
CONCLUSION: Hepatitis B viral DNA load at 24 wk of antiviral treatment in patients with chronic hepatitis B is a predictor of the viral load and response rate at 96 wk. PMID: 28522916 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2017 Category: Gastroenterology Authors: Fu XY, Tan DM, Liu CM, Gu B, Hu LH, Peng ZT, Chen B, Xie YL, Gong HY, Hu XX, Yao LH, Xu XP, Fu ZY, He LQ, Li SH, Long YZ, Li DH, Gu JL, Peng SF Tags: World J Gastroenterol Source Type: research

Effects of Chinese herbal medicine Xiangbin prescription on gastrointestinal motility.
Abstract AIM: To investigate the effects of Xiangbin prescription (XBP), a Chinese herbal concoction, on gastrointestinal motility. METHODS: Forty healthy volunteers were recruited for this randomized controlled trial of XBP. Antroduodenojejunal manometry was used to monitor gastrointestinal motility in these subjects. After the subjects had fasted for at least 12 h, XBP (n = 30) or placebo (n = 10) was orally administrated and gastrointestinal motility was recorded for 4 h. Plasma motilin and ghrelin were measured by enzyme-linked immunosorbent assay. RESULTS: Oral administration of XBP significantly in...
Source: World Journal of Gastroenterology : WJG - April 28, 2017 Category: Gastroenterology Authors: Jiang Z, Cao LX, Liu B, Chen QC, Shang WF, Zhou L, Li DY, Guo DA, Chen ZQ Tags: World J Gastroenterol Source Type: research

Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis: A global survey of physicians' practice.
Abstract AIM: To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates (5ASA) with corticosteroids (CS) versus corticosteroids alone for patients with active ulcerative colitis (UC). METHODS: A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characte...
Source: World Journal of Gastroenterology : WJG - April 28, 2017 Category: Gastroenterology Authors: Ben-Horin S, Andrews JM, Katsanos KH, Rieder F, Steinwurz F, Karmiris K, Cheon JH, Moran GW, Cesarini M, Stone CD, Schwartz D, Protic M, Roblin X, Roda G, Chen MH, Har-Noy O, Bernstein CN Tags: World J Gastroenterol Source Type: research

Protein-losing pseudomembranous colitis with cap polyposis-like features.
Abstract Protein-losing enteropathy (PLE) is characterized by loss of serum proteins into the gastrointestinal tract. It may lead to hypoproteinemia and clinically present as protein deficiency edema, ascites, pleural or pericardial effusion and/or malnutrition. In most cases the site of protein loss is the small intestine. Here we present an unusual case of severe PLE in a 55-year old female with a one-year history of recurrent diarrhea, crampy abdominal pain, and peripheral edema. Endoscopy and MRI showed a diffuse inflammatory thickening of the sigmoid colon and the rectum. Surgical resection of the involved co...
Source: World Journal of Gastroenterology : WJG - April 28, 2017 Category: Gastroenterology Authors: Kreisel W, Ruf G, Salm R, Lazaro A, Bengsch B, Globig AM, Fisch P, Lassmann S, Schmitt-Graeff A Tags: World J Gastroenterol Source Type: research

Dietary compliance in celiac disease.
Abstract Celiac disease is an immune-mediated disorder that causes severe architectural disturbance in the small intestinal mucosa of genetically-predisposed individuals. Impaired absorption of multiple nutrients results and diarrhea and weight loss develop. Evidence has accumulated that a strict gluten-free diet can result in resolution of diarrhea, weight gain and normalization of nutrient malabsorption. In addition, histopathological changes also normalize, but this histopathological response appears to be time-dependent, sex-dependent and age-dependent. Compliance to a gluten-free diet is difficult and costly ...
Source: World Journal of Gastroenterology : WJG - April 21, 2017 Category: Gastroenterology Authors: Freeman HJ Tags: World J Gastroenterol Source Type: research

Is there still a role for the hepatic locoregional treatment of metastatic neuroendocrine tumors in the era of systemic targeted therapies?
Abstract Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) frequently present with distant metastases at the time of diagnosis and the liver is the most frequent site of spreading. The early identification of metastatic disease represents a major prognostic factor for GEP-NENs patients. Radical surgical resection, which is feasible for a minority of patients, is considered the only curative option, while the best management for patients with unresectable liver metastases is still being debated. In the last few years, a number of locoregional and systemic treatments has become available for GEP-NEN patient...
Source: World Journal of Gastroenterology : WJG - April 21, 2017 Category: Gastroenterology Authors: Cavalcoli F, Rausa E, Conte D, Nicolini AF, Massironi S Tags: World J Gastroenterol Source Type: research

Hepatitis B virus infection and alcohol consumption.
Abstract Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, and the second most common cause of cancer deaths worldwide. The top three causes of HCC are hepatitis B virus (HBV), hepatitis C virus (HCV), and alcoholic liver disease. Owing to recent advances in direct-acting antiviral agents, HCV can now be eradicated in almost all patients. HBV infection and alcoholic liver disease are expected, therefore, to become the leading causes of HCC in the future. However, the association between alcohol consumption and chronic hepatitis B in the progression of liver disease is less well unders...
Source: World Journal of Gastroenterology : WJG - April 21, 2017 Category: Gastroenterology Authors: Iida-Ueno A, Enomoto M, Tamori A, Kawada N Tags: World J Gastroenterol Source Type: research

Endoscopic management of pancreatic fluid collections-revisited.
Abstract The development of pancreatic fluid collections (PFC) is one of the most common complications of acute severe pancreatitis. Most of the acute pancreatic fluid collections resolve and do not require endoscopic drainage. However, a substantial proportion of acute necrotic collections get walled off and may require drainage. Endoscopic drainage of PFC is now the preferred mode of drainage due to reduced morbidity and mortality as compared to surgical or percutaneous drainage. With the introduction of new metal stents, the efficiency of endoscopic drainage has improved and the task of direct endoscopic necros...
Source: World Journal of Gastroenterology : WJG - April 21, 2017 Category: Gastroenterology Authors: Nabi Z, Basha J, Reddy DN Tags: World J Gastroenterol Source Type: research

Overexpression of fibrinogen-like protein 2 protects against T cell-induced colitis.
CONCLUSION: Here we show that fgl2(Tg) Teff are hypoproliferative and do not induce colitis. We further demonstrate that fgl2(Tg) Treg prevent colitis in contrast to fgl2(+/+) Treg, which were only partially protective. These studies collectively provide a rationale for exploring the use of FGL2 or Treg expressing high levels of FGL2 in the treatment of inflammatory bowel disease. PMID: 28487604 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2017 Category: Gastroenterology Authors: Bartczak A, Zhang J, Adeyi O, Amir A, Grant D, Gorczynski R, Selzner N, Chruscinski A, Levy GA Tags: World J Gastroenterol Source Type: research

Changes in human hepatic metabolism in steatosis and cirrhosis.
CONCLUSION: Our high throughput, non-destructive technique for multiple analyte quantification in human liver specimens has potential for identification of biomarkers with prognostic and diagnostic significance. PMID: 28487605 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2017 Category: Gastroenterology Authors: Schofield Z, Reed MA, Newsome PN, Adams DH, Günther UL, Lalor PF Tags: World J Gastroenterol Source Type: research

Effect of Lactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 on the healthy gut microbiota composition at phyla and species level: A preliminary study.
CONCLUSION: B. longum BB536 and L. rhamnosus HN001 showed the ability to modulate the gut microbiota composition, leading to a significant reduction of potentially harmful bacteria and an increase of beneficial ones. Further studies are needed to better understand the specific mechanisms involved in gut microbiota modulation. PMID: 28487606 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2017 Category: Gastroenterology Authors: Toscano M, De Grandi R, Stronati L, De Vecchi E, Drago L Tags: World J Gastroenterol Source Type: research

Effects of Hwangryunhaedok-tang on gastrointestinal motility function in mice.
CONCLUSION: These results suggest that HHT is a novel candidate for the development of a gastroprokinetic agent for the GI tract. PMID: 28487607 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2017 Category: Gastroenterology Authors: Kim H, Kim I, Lee MC, Kim HJ, Lee GS, Kim H, Kim BJ Tags: World J Gastroenterol Source Type: research

Role of Δ133p53 isoform in NF-κB inhibitor PDTC-mediated growth inhibition of MKN45 gastric cancer cells.
Role of Δ133p53 isoform in NF-κB inhibitor PDTC-mediated growth inhibition of MKN45 gastric cancer cells. World J Gastroenterol. 2017 Apr 21;23(15):2716-2722 Authors: Zhang HM, Sang XG, Wang YZ, Cui C, Zhang L, Ji WS Abstract AIM: To investigate the role of Δ133p53 isoform in nuclear factor-κB (NF-κB) inhibitor pyrrolidine dithiocarbamate (PDTC)-mediated growth inhibition of MKN45 gastric cancer cells. METHODS: The growth rate of MKN45 cells after treatment with different concentrations of only PDTC or PTDC in combination with cisplatin was detected by the CCK-8 assa...
Source: World Journal of Gastroenterology : WJG - April 21, 2017 Category: Gastroenterology Authors: Zhang HM, Sang XG, Wang YZ, Cui C, Zhang L, Ji WS Tags: World J Gastroenterol Source Type: research

Optimal treatment for Siewert type II and III adenocarcinoma of the esophagogastric junction: A retrospective cohort study with long-term follow-up.
CONCLUSION: LN along the lesser curvature, right and left paracardial LN, and LN along the left gastric artery should be dissected in patients with Siewert type II or III adenocarcinoma of the esophagogastric junction. Patients with vigorous venous invasion and LNR of> 0.16 should be treated with aggressive adjuvant chemotherapy to improve survival outcomes. PMID: 28487609 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2017 Category: Gastroenterology Authors: Hosoda K, Yamashita K, Moriya H, Mieno H, Watanabe M Tags: World J Gastroenterol Source Type: research

Colorectal and interval cancers of the Colorectal Cancer Screening Program in the Basque Country (Spain).
zea I Abstract AIM: To assess proportions, related conditions and survival of interval cancer (IC). METHODS: The programme has a linkage with different clinical databases and cancer registers to allow suitable evaluation. This evaluation involves the detection of ICs after a negative faecal inmunochemical test (FIT), interval cancer FIT (IC-FIT) prior to a subsequent invitation, and the detection of ICs after a positive FIT and confirmatory diagnosis without colorectal cancer (CRC) detected and before the following recommended colonoscopy, IC-colonoscopy. We conducted a retrospective observational study analy...
Source: World Journal of Gastroenterology : WJG - April 21, 2017 Category: Gastroenterology Authors: Portillo I, Arana-Arri E, Idigoras I, Bilbao I, Martínez-Indart L, Bujanda L, Gutierrez-Ibarluzea I Tags: World J Gastroenterol Source Type: research

Performance of 18-fluoro-2-deoxyglucose positron emission tomography for esophageal cancer screening.
CONCLUSION: This study is the first to clarify the FDG-PET performance for EC screening. Based on the low screen sensitivity, FDG-PET is considered to be difficult to use as a screening modality for ECs. PMID: 28487611 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2017 Category: Gastroenterology Authors: Sekiguchi M, Terauchi T, Kakugawa Y, Shimada N, Saito Y, Matsuda T Tags: World J Gastroenterol Source Type: research

Association of obesity with Helicobacter pylori infection: A retrospective study.
CONCLUSION: H. pylori infection was not associated with overweight/obesity observed from the retrospective study in this Chinese population. PMID: 28487612 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2017 Category: Gastroenterology Authors: Xu MY, Liu L, Yuan BS, Yin J, Lu QB Tags: World J Gastroenterol Source Type: research

Outcomes and prognostic factors of patients with stage IB and IIA pancreatic cancer according to the 8(th) edition American Joint Committee on Cancer criteria.
CONCLUSION: The prognostic factors for stage IB and IIA patients are different, but age is the independent prognostic factor for all patients. The survival time of stage IB and IIA patients has no significant difference. PMID: 28487613 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2017 Category: Gastroenterology Authors: Li Y, Tang CG, Zhao Y, Cao WY, Qu GF Tags: World J Gastroenterol Source Type: research

Patients with non-viral liver disease have a greater tumor burden and less curative treatment options when diagnosed with hepatocellular carcinoma.
Abstract AIM: To assess the impact of underlying liver disease etiology on the presenting features and outcomes in a large cohort of patients with hepatocellular carcinoma (HCC). METHODS: A prospective database of all patients with HCC was established from 1998 to March 2012. One thousand and seventy-eight patients were categorized into three groups, based on the etiology of their liver disease: hepatitis B virus (HBV), hepatitis C virus (HCV) and non-viral liver disease (NVLD). Overall survival was determined by Kaplan Meier analysis to time of death or last follow-up. RESULTS: HCC patients with HCV (85...
Source: World Journal of Gastroenterology : WJG - April 21, 2017 Category: Gastroenterology Authors: Mohsen W, Rodov M, Prakoso E, Charlton B, Bowen DG, Koorey DJ, Shackel NA, McCaughan GW, Strasser SI Tags: World J Gastroenterol Source Type: research

Urinary metabolomics analysis identifies key biomarkers of different stages of nonalcoholic fatty liver disease.
CONCLUSION: These findings suggested that a panel of biomarkers could distinguish between NAFLD and NASH, and could help to determine the molecular mechanism involved in the process of developing NASH from NAFLD. Urinary biomarkers may be diagnostic in these patients and could be used to assess responses to therapeutic interventions. PMID: 28487615 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2017 Category: Gastroenterology Authors: Dong S, Zhan ZY, Cao HY, Wu C, Bian YQ, Li JY, Cheng GH, Liu P, Sun MY Tags: World J Gastroenterol Source Type: research

Age-related impairment of esophagogastric junction relaxation and bolus flow time.
Abstract AIM: To investigate the functional effects of abnormal esophagogastric (EGJ) measurements in asymptomatic healthy volunteers over eighty years of age. METHODS: Data from 30 young controls (11 M, mean age 37 ± 11 years) and 15 aged subjects (9 M, 85 ± 4 years) were compared for novel metrics of EGJ-function: EGJ-contractile integral (EGJ-CI), "total" EGJ-CI and bolus flow time (BFT). Data were acquired using a 3.2 mm, 25 pressure (1 cm spacing) and 12 impedance segment (2 cm) solid-state catheter (Unisensor and MMS Solar GI system) across the EGJ. Five swallows each of 5 mL liq...
Source: World Journal of Gastroenterology : WJG - April 21, 2017 Category: Gastroenterology Authors: Cock C, Besanko LK, Burgstad CM, Thompson A, Kritas S, Heddle R, Fraser RJ, Omari TI Tags: World J Gastroenterol Source Type: research

Endoscopic ultrasound-guided cutting of holes and deep biopsy for diagnosis of gastric infiltrative tumors and gastrointestinal submucosal tumors using a novel vertical diathermic loop.
CONCLUSION: EUS-CHDB may be a technically feasible and safe option for patients with gastric infiltrative tumors or gastrointestinal submucosal tumors. EUS-CHDB may be used as a remedial or even preferred biopsy method for submucosal lesions. PMID: 28487617 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2017 Category: Gastroenterology Authors: Liu YM, Yang XJ Tags: World J Gastroenterol Source Type: research

Non-ALT biomarkers for markedly abnormal liver histology among Chinese persistently normal alanine aminotransferase-chronic hepatitis B patients.
CONCLUSION: A considerable proportion of marked histological abnormalities existed in our cohort, who will benefit from optimal therapeutic strategies administered according to predictive indication by AST, PLT and GGT levels. PMID: 28487618 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2017 Category: Gastroenterology Authors: Cheng JL, Wang XL, Yang SG, Zhao H, Wu JJ, Li LJ Tags: World J Gastroenterol Source Type: research

One step minilaparotomy-assisted transmesenteric portal vein recanalization combined with transjugular intrahepatic portosystemic shunt placement: A novel surgical proposal in pediatrics.
Abstract Transjugular intrahepatic portosystemic shunt (TIPS) placement is a standard procedure for the treatment of portal hypertension complications. When this conventional approach is not feasible, alternative procedures for systemic diversion of portal blood have been proposed. A one-step interventional approach, combining minilaparotomy-assisted transmesenteric (MAT) antegrade portal recanalization and TIPS, is described in an adolescent with recurrent esophageal varice bleeding and portal cavernoma (PC). A 16-year-old girl was admitted to our Unit because of repeated bleeding episodes over a short period of ...
Source: World Journal of Gastroenterology : WJG - April 21, 2017 Category: Gastroenterology Authors: Pelizzo G, Quaretti P, Moramarco LP, Corti R, Maestri M, Iacob G, Calcaterra V Tags: World J Gastroenterol Source Type: research

Noninvasive molecular analysis of Helicobacter pylori: Is it time for tailored first-line therapy?
In conclusion, despite poor validation, there is increasing evidence of a potential availability of noninvasive investigations able to detect H. pylori resistances to antibiotics. These kinds of analysis are currently at a very early phase of development and caution should be paid about their clinical application. Only further studies aimed to evaluate their sensitivity and specificity will afford novel data for solid considerations. Nevertheless, noninvasive molecular tests may improve patient compliance, time/cost of infection management and therapeutic outcome. Moreover, the potential risk of a future increase of resist...
Source: World Journal of Gastroenterology : WJG - April 14, 2017 Category: Gastroenterology Authors: Ierardi E, Giorgio F, Iannone A, Losurdo G, Principi M, Barone M, Pisani A, Di Leo A Tags: World J Gastroenterol Source Type: research

Pathogenesis and clinical spectrum of primary sclerosing cholangitis.
Abstract Primary sclerosing cholangitis (PSC) is a disease of the biliary tract, which has been documented in the literature since 1867. This disease has a strong predilection for affecting men and can be seen in individuals as young as 2 years of age. PSC has a strong associated with inflammatory bowel disease, more commonly with ulcerative colitis, and is also part of the clinical spectrum of IgG4-related diseases. Small-duct PSC, a variant of PSC, also has an association with inflammatory bowel disease. The exact pathogenesis of PSC is not well understood at present, however, is likely a combination of a geneti...
Source: World Journal of Gastroenterology : WJG - April 14, 2017 Category: Gastroenterology Authors: Gidwaney NG, Pawa S, Das KM Tags: World J Gastroenterol Source Type: research

Biliary tract cancer stem cells - translational options and challenges.
Abstract Management of biliary tract cancer remains challenging. Tumors show high recurrence rates and therapeutic resistance, leading to dismal prognosis and short survival. The cancer stem cell model states that a tumor is a heterogeneous conglomerate of cells, in which a certain subpopulation of cells - the cancer stem cells - possesses stem cell properties. Cancer stem cells have high clinical relevance due to their potential contributions to development, progression and aggressiveness as well as recurrence and metastasis of malignant tumors. Consequently, reliable identification of as well as pharmacological ...
Source: World Journal of Gastroenterology : WJG - April 14, 2017 Category: Gastroenterology Authors: Mayr C, Ocker M, Ritter M, Pichler M, Neureiter D, Kiesslich T Tags: World J Gastroenterol Source Type: research

Potential role of nutraceutical compounds in inflammatory bowel disease.
Abstract Conventional therapies for inflammatory bowel diseases (IBD) involve combinations of pharmacologic agents such as aminosalicylates, azathioprine, and corticosteroids. Recently, the therapeutic scenario has been heavily increased by the introduction of agents including monoclonal antibodies targeted to specific proinflammatory cytokines, to adhesion molecules, and the induction of anti-inflammatory cytokines and T-cell activation. However, the use of these drugs is accompanied by a certain number of side effects, with some of them being quite severe, rising concerns about the safety profile. Furthermore, t...
Source: World Journal of Gastroenterology : WJG - April 14, 2017 Category: Gastroenterology Authors: Larussa T, Imeneo M, Luzza F Tags: World J Gastroenterol Source Type: research

Unusual gastric tumors and tumor-like lesions: Radiological with pathological correlation and literature review.
Abstract Although gastric tumors have overlapping radiologic appearances, some unusual tumors may present specific imaging features. Using multidetector computed tomography (MDCT), with water as a negative oral contrast agent and intravenous contrast medium, can provide critical information for the diagnosis of gastric diseases. In addition, MDCT can evaluate the involvement of the gastric wall and extragastric extent of the disease, as compared with gastroenteroscopy and double-contrast upper gastrointestinal study. Regarding lesion location and size, enhancing and growth patterns, presence of calcification or fa...
Source: World Journal of Gastroenterology : WJG - April 14, 2017 Category: Gastroenterology Authors: Lin YM, Chiu NC, Li AF, Liu CA, Chou YH, Chiou YY Tags: World J Gastroenterol Source Type: research

New progress in roles of nitric oxide during hepatic ischemia reperfusion injury.
Abstract Hepatic ischemia reperfusion injury (HIRI) is a clinical condition which may lead to cellular injury and organ dysfunction. The role of nitric oxide (NO) in HIRI is complicated and inconclusive. NO produced by endothelial nitric oxide synthase (eNOS) activation plays a protective role during early HIRI. But eNOS overexpression and the resulting excessive NO bioavailability can aggravate liver injury. NO induced by inducible nitric oxide synthase (iNOS) may have either a protective or a deleterious effect during the early phase of HIRI, but it may protect the liver during late HIRI. Here, we reviewed the l...
Source: World Journal of Gastroenterology : WJG - April 14, 2017 Category: Gastroenterology Authors: Zhang YQ, Ding N, Zeng YF, Xiang YY, Yang MW, Hong FF, Yang SL Tags: World J Gastroenterol Source Type: research

Berberine displays antitumor activity in esophageal cancer cells in vitro.
Abstract AIM: To investigate the effects of berberine on esophageal cancer (EC) cells and its molecular mechanisms. METHODS: Human esophageal squamous cell carcinoma cell line KYSE-70 and esophageal adenocarcinoma cell line SKGT4 were used. The effects of berberine on cell proliferation were evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. For cell cycle progression, KYSE-70 cells were stained with propidium iodide (PI) staining buffer (10 mg/mL PI and 100 mg/mL RNase A) for 30 min and cell cycle was analyzed using a BD FACSCalibur flow cytometer. For apoptosis ass...
Source: World Journal of Gastroenterology : WJG - April 14, 2017 Category: Gastroenterology Authors: Jiang SX, Qi B, Yao WJ, Gu CW, Wei XF, Zhao Y, Liu YZ, Zhao BS Tags: World J Gastroenterol Source Type: research

Clinical utility of the platelet-lymphocyte ratio as a predictor of postoperative complications after radical gastrectomy for clinical T2-4 gastric cancer.
Abstract AIM: To identify simple and sensitive markers for postoperative complications after gastrectomy, the predictive values were compared among candidate preoperative factors. METHODS: Three-hundred and twelve patients with previously untreated clinical T2-4 gastric cancer who underwent a D2 standard gastrectomy (distal gastrectomy or total gastrectomy) were included in the analysis. Correlations between 21 parameters that can be determined by preoperative routine blood tests and clinically relevant postoperative complications (grade II or higher according to the Clavien-Dindo classification) were evaluat...
Source: World Journal of Gastroenterology : WJG - April 14, 2017 Category: Gastroenterology Authors: Inaoka K, Kanda M, Uda H, Tanaka Y, Tanaka C, Kobayashi D, Takami H, Iwata N, Hayashi M, Niwa Y, Yamada S, Fujii T, Sugimoto H, Murotani K, Fujiwara M, Kodera Y Tags: World J Gastroenterol Source Type: research

Colors of vegetables and fruits and the risks of colorectal cancer.
CONCLUSION: Vegetables and fruits intake from various color groups may protect against colorectal cancer. PMID: 28465637 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 14, 2017 Category: Gastroenterology Authors: Lee J, Shin A, Oh JH, Kim J Tags: World J Gastroenterol Source Type: research

Impact of vitamin D on the hospitalization rate of Crohn's disease patients seen at a tertiary care center.
Abstract AIM: To study the association between vitamin D level and hospitalization rate in Crohn's disease (CD) patients. METHODS: We designed a retrospective cohort study using adult patients (> 19 years) with CD followed for at least one year at our inflammatory bowel disease center. Vitamin D levels were divided into: low mean vitamin D level (
Source: World Journal of Gastroenterology : WJG - April 14, 2017 Category: Gastroenterology Authors: Venkata KVR, Arora SS, Xie FL, Malik TA Tags: World J Gastroenterol Source Type: research