Surgical specimen extraction via a prophylactic ileostomy procedure: A minimally invasive technique for laparoscopic rectal cancer surgery.
CONCLUSION: Surgical specimen extraction via a prophylactic ileostomy procedure represents a secure and feasible approach to laparoscopic rectal cancer surgery, and embodies the principle of minimally invasive surgery. PMID: 29358887 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2018 Category: Gastroenterology Authors: Wang P, Liang JW, Zhou HT, Wang Z, Zhou ZX Tags: World J Gastroenterol Source Type: research

Characterization of biofilms in biliary stents and potential factors involved in occlusion.
Abstract AIM: To quantify the components in biofilms and analyze the predisposing factors involved in occlusion of biliary stents. METHODS: In a prospective study conducted from April 2011 to March 2014 at a tertiary care hospital, all consecutive patients who required endoscopic biliary stent exchange/removal were included. Etiology of the biliary disease was diagnosed by imaging, cytology and on follow-up. Clinical details of patients with biliary stent retrieval were noted. All extracted stents were collected in sterile containers and immediately processed for quantification of biofilm proteins and polysac...
Source: World Journal of Gastroenterology : WJG - January 7, 2018 Category: Gastroenterology Authors: Vaishnavi C, Samanta J, Kochhar R Tags: World J Gastroenterol Source Type: research

Systematic review of colorectal cancer screening guidelines for average-risk adults: Summarizing the current global recommendations.
CONCLUSION: Average risk individuals between 50 and 75 years should undergo CRC screening. Recommendations for optimal surveillance intervals, preferred tests/test cascade as well as the optimal timing when to start and stop screening differ regionally and should be considered for clinical decision making. Furthermore, local resource availability and patient preferences are important to increase CRC screening uptake, as any screening is better than none. PMID: 29358889 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2018 Category: Gastroenterology Authors: Bénard F, Barkun AN, Martel M, von Renteln D Tags: World J Gastroenterol Source Type: research

Probiotic monotherapy and Helicobacter pylori eradication: A systematic review with pooled-data analysis.
Abstract AIM: To define probiotic monotherapy effect on Helicobacter pylori (H. pylori) status by performing a systematic review. METHODS: Methods of analysis and inclusion criteria were based on PRISMA recommendations. Relevant publications were identified by searching PubMed, MEDLINE, Science Direct, and EMBASE. The end-point was to estimate eradication rate and urea breath test delta value before and after probiotic monotherapy across all studies and, overall, with a pooled data analysis. Adverse events of probiotic therapy were evaluated. The data were expressed as proportions/percentages, and 95%CIs were...
Source: World Journal of Gastroenterology : WJG - January 7, 2018 Category: Gastroenterology Authors: Losurdo G, Cubisino R, Barone M, Principi M, Leandro G, Ierardi E, Di Leo A Tags: World J Gastroenterol Source Type: research

Long-term survival after gastrectomy and metastasectomy for gastric cancer with synchronous bone metastasis.
We report herein the case of a 53-year-old man who presented with primary remnant gastric cancer with bone metastasis. The patient requested further investigations after detection of a metastatic lesion in the 2nd lumbar vertebra during evaluation for back pain that had persisted for 3 mo. No other metastatic lesions were detected. He underwent total gastrectomy and palliative metastasectomy to aid in reduction of symptoms, and he received combination chemotherapy with tegafur (S-1) and cisplatin. The patient survived for about 60 mo after surgery. Currently, there is no treatment guideline for gastric cancer with bone met...
Source: World Journal of Gastroenterology : WJG - January 7, 2018 Category: Gastroenterology Authors: Choi YJ, Kim DH, Han HS, Han JH, Son SM, Kim DS, Yun HY Tags: World J Gastroenterol Source Type: research

Emergent single-balloon enteroscopy for overt bleeding of small intestinal vascular malformation.
Abstract A 28-year-old man presented with anemia symptoms and intermittent tarry stool passage for three days. No stigmata of hemorrhage were identified using esophagogastroduodenoscopy, ileocolonoscopy, and contrast-enhanced computed tomography. He then developed massive tarry stool passage with profound hypovolemic shock and hypoxic respiratory failure. Emergent angiography revealed active bleeder, probably from the jejunal branches of the superior mesenteric artery, but embolization was not performed due to possible subsequent extensive bowel ischemia. His airway was secured via endotracheal intubation with ven...
Source: World Journal of Gastroenterology : WJG - January 7, 2018 Category: Gastroenterology Authors: Chung CS, Chen KC, Chou YH, Chen KH Tags: World J Gastroenterol Source Type: research

Serum levels of angiotensin converting enzyme as a biomarker of liver fibrosis.
va AC Abstract The renin angiotensin system (RAS) is classically conceived as a circulating hormonal system involved in blood pressure control and hydroelectrolyte balance. The discovery that RAS components are locally expressed in a wide range of organs and tissues, including the liver, pointed to a role for this system in the pathogenesis of several conditions including hepatic fibrosis and cirrhosis. It has been widely reported that the classical RAS axis composed by the angiotensin converting enzyme (ACE)-angiotensin (Ang) II-Ang type 1 (AT1) receptor mediates pro-inflammatory, pro-thrombotic, and pro-fibrotic...
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Miranda AS, Simões E Silva AC Tags: World J Gastroenterol Source Type: research

Mechanisms of autophagy activation in endothelial cell and their targeting during normothermic machine liver perfusion.
Abstract Ischaemia-reperfusion injury (IRI) is the leading cause of injury seen in the liver following transplantation. IRI also causes injury following liver surgery and haemodynamic shock. The first cells within the liver to be injured by IRI are the liver sinusoidal endothelial cells (LSEC). Recent evidence suggests that LSEC co-ordinate and regulates the livers response to a variety of injuries. It is becoming increasingly apparent that the cyto-protective cellular process of autophagy is a key regulator of IRI. In particular LSEC autophagy may be an essential gatekeeper to the development of IRI. The recent a...
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Boteon YL, Laing R, Mergental H, Reynolds GM, Mirza DF, Afford SC, Bhogal RH Tags: World J Gastroenterol Source Type: research

Human small intestine is capable of restoring barrier function after short ischemic periods.
Abstract AIM: To assess intestinal barrier function during human intestinal ischemia and reperfusion (IR). METHODS: In a human experimental model, 6 cm of jejunum was selectively exposed to 30 min of ischemia (I) followed by 30 and 120 min of reperfusion (R). A sham procedure was also performed. Blood and tissue was sampled at all-time points. Functional barrier function was assessed using dual-sugar absorption tests with lactulose (L) and rhamnose (R). Plasma concentrations of citrulline, an amino acid described as marker for enterocyte function were measured as marker of metabolic enterocytes restoration. D...
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Schellekens DH, Hundscheid IH, Leenarts CA, Grootjans J, Lenaerts K, Buurman WA, Dejong CH, Derikx JP Tags: World J Gastroenterol Source Type: research

Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights.
CONCLUSION: BPC 157 is a fundamental treatment that quickly restores blood supply to the ischemically injured area and rapidly activates collaterals. This effect involves the NO system. PMID: 29358856 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Duzel A, Vlainic J, Antunovic M, Malekinusic D, Vrdoljak B, Samara M, Gojkovic S, Krezic I, Vidovic T, Bilic Z, Knezevic M, Sever M, Lojo N, Kokot A, Kolovrat M, Drmic D, Vukojevic J, Kralj T, Kasnik K, Siroglavic M, Seiwerth S, Sikiric P Tags: World J Gastroenterol Source Type: research

Exploring pathogenesis of primary biliary cholangitis by proteomics: A pilot study.
Abstract AIM: To explore the pathogenesis of primary biliary cholangitis (PBC) by identifying candidate autoantibodies in serum samples by proteomics and bioinformatics. METHODS: Nine antimitochondrial antibody (AMA)-positive PBC patients and nine age- and sex-matched AMA-negative PBC patients were recruited. Antigen enrichment technology was applied to capture autoantigens of human intrahepatic biliary epithelial cells (HiBECs) that are recognized by autoantibodies from the sera of PBC patients. Candidate autoantigens were identified by label-free mass spectrometry. Bioinformatics analysis with MaxQuant soft...
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Deng CW, Wang L, Fei YY, Hu CJ, Yang YJ, Peng LY, Zeng XF, Zhang FC, Li YZ Tags: World J Gastroenterol Source Type: research

Influence of TBX21 T-1993C variant on autoimmune hepatitis development by Yin-Yang 1 binding.
CONCLUSION: The repression of TBX21 expression by high-affinity binding of YY1 to the -1993C allele may contribute to a decreased development of AIH-1 via suppression of type 1 immunity. PMID: 29358858 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Sun W, Wu HY, Chen S Tags: World J Gastroenterol Source Type: research

Astragaloside IV inhibits pathological functions of gastric cancer-associated fibroblasts.
Abstract AIM: To investigate the inhibitory effect of astragaloside IV on the pathological functions of cancer-associated fibroblasts, and to explore the underlying mechanism. METHODS: Paired gastric normal fibroblast (GNF) and gastric cancer-associated fibroblast (GCAF) cultures were established from resected tissues. GCAFs were treated with vehicle control or different concentrations of astragaloside IV. Conditioned media were prepared from GNFs, GCAFs, control-treated GCAFs, and astragaloside IV-treated GCAFs, and used to culture BGC-823 human gastric cancer cells. Proliferation, migration and invasion cap...
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Wang ZF, Ma DG, Zhu Z, Mu YP, Yang YY, Feng L, Yang H, Liang JQ, Liu YY, Liu L, Lu HW Tags: World J Gastroenterol Source Type: research

Prevalence and outcomes of pancreatic cystic neoplasms in liver transplant recipients.
CONCLUSION: The prevalence of PCNs in LT recipients was similar to the general population (3.6%, 31/872). Side-branch IPMNs do not appear to have accelerated malignant potential in post-LT patients, indicating the current surveillance guidelines are applicable to this group. PMID: 29358860 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Liu K, Joshi V, van Camp L, Yang QW, Baars JE, Strasser SI, McCaughan GW, Majumdar A, Saxena P, Kaffes AJ Tags: World J Gastroenterol Source Type: research

Analysis of 12 variants in the development of gastric and colorectal cancers.
CONCLUSION: These findings are important for the comprehension of gastric and CRC development, particularly in highly admixed populations, such as the Brazilian population. PMID: 29358861 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Cavalcante GC, Amador MA, Ribeiro Dos Santos AM, Carvalho DC, Andrade RB, Pereira EE, Fernandes MR, Costa DF, Santos NP, Assumpção PP, Ribeiro Dos Santos Â, Santos S Tags: World J Gastroenterol Source Type: research

Childhood-onset inflammatory bowel diseases associated with mutation of Wiskott-Aldrich syndrome protein gene.
CONCLUSION: Despite the lack of typical clinical manifestations of WAS, low expression of WASP could be associated with the pathogenesis of a subtype of IBD patients. PMID: 29358862 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Ohya T, Yanagimachi M, Iwasawa K, Umetsu S, Sogo T, Inui A, Fujisawa T, Ito S Tags: World J Gastroenterol Source Type: research

Comparison of totally laparoscopic total gastrectomy using an endoscopic linear stapler with laparoscopic-assisted total gastrectomy using a circular stapler in patients with gastric cancer: A single-center experience.
Abstract AIM: To evaluate the safety and efficacy of totally laparoscopic total gastrectomy (TLTG) with esophagojejunostomy using a linear stapler compared with laparoscopic-assisted total gastrectomy (LATG) using a circular stapler in gastric cancer patients. METHODS: We retrospectively reviewed 687 patients who underwent laparoscopic total gastrectomy for gastric cancer at a single institution from August 2008 to August 2014. The patients were divided into two groups according to the type of operation: 421 patients underwent TLTG and 266 underwent LATG. Clinicopathologic characteristics and surgical outcome...
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Gong CS, Kim BS, Kim HS Tags: World J Gastroenterol Source Type: research

Prognostic significance of pretreatment serum carcinoembryonic antigen levels in gastric cancer with pathological lymph node-negative: A large sample single-center retrospective study.
Abstract AIM: To assess whether elevated serum carcinoembryonic antigen (CEA) is in the inferior prognosis for pathological lymph node-negative (pN0) gastric cancer (GC) patients who underwent D2 gastrectomy. METHODS: About 469 pN0 GC patients, who received D2 radical gastrectomy were retrospectively analyzed. The X-tile plots cut-off point for CEA were 30.02 ng/mL using minimum P-value from log-rank χ2 statistics, and pN0 GC patients were assigned to two groups: those more than 30.02 ng/mL (n = 48; CEA-high group) and those less than 30.02 ng/mL (n = 421; CEA-low group). Clinicopathologic characteristics...
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Xiao J, Ye ZS, Wei SH, Zeng Y, Lin ZM, Wang Y, Teng WH, Chen LC Tags: World J Gastroenterol Source Type: research

Fecal microbiota transplantation induces remission of infantile allergic colitis through gut microbiota re-establishment.
CONCLUSION: FMT is a safe and effective method for treating pediatric patients with AC and restoring GM balance. PMID: 29358865 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Liu SX, Li YH, Dai WK, Li XS, Qiu CZ, Ruan ML, Zou B, Dong C, Liu YH, He JY, Huang ZH, Shu SN Tags: World J Gastroenterol Source Type: research

Prognostic value of lymph node metastasis in patients with T1-stage colorectal cancer from multiple centers in China.
Abstract AIM: To explore the features and prognostic value of lymph node metastasis in patients with T1-stage colorectal cancer (CRC). METHODS: In all, 321 cases of T1-stage CRC were selected from 10132 patients with CRC who received surgical therapy in six large-scale hospitals in China and were retrospectively analyzed. Univariate and multivariate analyses were performed to analyze the risk factors for lymphatic metastasis. A survival analysis was then performed to analyze the prognostic value of lymph node metastasis. RESULTS: The occurrence rate of T1 stage was 3.17% (321/10132); of these patients, t...
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Sun ZQ, Ma S, Zhou QB, Yang SX, Chang Y, Zeng XY, Ren WG, Han FH, Xie X, Zeng FY, Sun XT, Wang GX, Li Z, Zhang ZY, Song JM, Liu JB, Yuan WT Tags: World J Gastroenterol Source Type: research

Association between acute pancreatitis and small intestinal bacterial overgrowth assessed by hydrogen breath test.
Abstract AIM: To elucidate the effects of small intestinal bacterial overgrowth (SIBO) on the severity and complications of acute pancreatitis (AP). METHODS: In total, 208 patients with AP as defined by the revised Atlanta classification were admitted to Xuanwu Hospital of Capital Medical University from 2013 to 2016. All patients were admitted within 72 h of AP onset. The hydrogen breath test was performed 7 d after AP onset to detect hydrogen production and evaluate the development of SIBO. The incidence of SIBO was analyzed in patients with AP of three different severity grades. The association between SIB...
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Zhang M, Zhu HM, He F, Li BY, Li XC Tags: World J Gastroenterol Source Type: research

Endoscopic papillary large balloon dilatation with sphincterotomy is safe and effective for biliary stone removal independent of timing and size of sphincterotomy.
Abstract AIM: To describe the efficacy and safety of endoscopic papillary large balloon dilatation (EPLBD) in the management of bile duct stones in a Western population. METHODS: Data was collected from the endoscopic retrograde cholangiopancreatography (ERCP) and Radiology electronic database along with a review of case notes over a period of six years from 1st August 2009 to 31st July 2015 and incorporated into Microsoft excel. Statistical analyses were performed using MedCalc for Windows, version 12.5 (MedCalc Software, Ostend, Belgium). Simple statistical applications were applied in order to determine wh...
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Aujla UI, Ladep N, Dwyer L, Hood S, Stern N, Sturgess R Tags: World J Gastroenterol Source Type: research

Person-centered endoscopy safety checklist: Development, implementation, and evaluation.
Abstract AIM: To describe the development and implementation of a person-centered endoscopy safety checklist and to evaluate the effects of a "checklist intervention". METHODS: The checklist, based on previously published safety checklists, was developed and locally adapted, taking patient safety aspects into consideration and using a person-centered approach. This novel checklist was introduced to the staff of an endoscopy unit at a Stockholm University Hospital during half-day seminars and team training sessions. Structured observations of the endoscopy team's performance were conducted before and...
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Dubois H, Schmidt PT, Creutzfeldt J, Bergenmar M Tags: World J Gastroenterol Source Type: research

Multicenter, randomized study to optimize bowel preparation for colon capsule endoscopy.
Abstract AIM: To assess the cleansing efficacy and safety of a new Colon capsule endoscopy (CCE) bowel preparation regimen. METHODS: This was a multicenter, prospective, randomized, controlled study comparing two CCE regimens. Subjects were asymptomatic and average risk for colorectal cancer. The second generation CCE system (PillCam® COLON 2; Medtronic, Yoqneam, Israel) was utilized. Preparation regimens differed in the 1st and 2nd boosts with the Study regimen using oral sulfate solution (89 mL) with diatrizoate meglumine and diatrizoate sodium solution ("diatrizoate solution") (boost 1 = 60 m...
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Kastenberg D, Jr WCB, Romeo DP, Kashyap PK, Pound DC, Papageorgiou N, Sainz IF, Sokach CE, Rex DK Tags: World J Gastroenterol Source Type: research

Fusobacterium's link to colorectal neoplasia sequenced: A systematic review and future insights.
CONCLUSION: Evidence suggests a potential active role of Fusobacterium, specifically F. nucleatum, in CRC. Future prospective and experimental human studies would fill an important gap in this literature. PMID: 29358871 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Hussan H, Clinton SK, Roberts K, Bailey MT Tags: World J Gastroenterol Source Type: research

Psychiatric morbidity after surgery for inflammatory bowel disease: A systematic review.
CONCLUSION: The review cannot give any clear answer to the risks of psychiatric morbidity after surgery for IBD studies with the lowest risk of bias indicated an increased risk of depression among surgical patients with Crohn's disease and increased risk of anxiety among patients with ulcerative colitis. PMID: 29358872 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Zangenberg MS, El-Hussuna A Tags: World J Gastroenterol Source Type: research

Stricturing Crohn's disease-like colitis in a patient treated with belatacept.
run G Abstract Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) modifying agents have been involved in the development of intestinal inflammation, especially therapeutic monoclonal antibodies directed against CTLA-4. Here we report the appearance of a severe stricturing Crohn's disease-like colitis in a patient with a kidney allograft who was treated with belatacept, a recombinant CTLA-4-Ig fusion protein. PMID: 29358873 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Bozon A, Jeantet G, Rivière B, Funakoshi N, Dufour G, Combes R, Valats JC, Delmas S, Serre JE, Bismuth M, Ramos J, Le Quintrec M, Blanc P, Pineton de Chambrun G Tags: World J Gastroenterol Source Type: research

Emphysematous pancreatitis associated with penetrating duodenal ulcer.
Abstract In the "proton pump inhibitors era", a penetrating peptic ulcer (PPU) represents an exceptional cause of abdominal pain, and was more frequently observed in the past where there was not an effective antacid treatment. Ulcer-induced pancreatitis is very rare, too, and manifests with persistent, intense pain radiating to the back. A mild to severe pancreatitis with peripancreatic fluid collection can be observed at imaging. However, only a few cases of association between PPU and emphysematous pancreatitis (EP) have been published in the literature. EP is a rare but potentially fatal form of acute...
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Tana C, Silingardi M, Giamberardino MA, Cipollone F, Meschi T, Schiavone C Tags: World J Gastroenterol Source Type: research

Infiltrative xanthogranulomatous cholecystitis mimicking aggressive gallbladder carcinoma: A diagnostic and therapeutic dilemma.
Fondevila C Abstract Xanthogranulomatous cholecystitis (XGC) is an uncommon variant of chronic cholecystitis. The perioperative findings in aggressive cases may be indistinguishable from those of gallbladder or biliary tract carcinomas. Three patients presented mass lesions that infiltrated the hepatic hilum, provoked biliary dilatation and jaundice, and were indicative of malignancy. Surgical excision was performed following oncological principles and included extirpation of the gallbladder, extrahepatic bile duct, and hilar lymph nodes, as well as partial hepatectomy. Postoperative morbidity was minimal. Surgica...
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Nacif LS, Hessheimer AJ, Rodríguez Gómez S, Montironi C, Fondevila C Tags: World J Gastroenterol Source Type: research

Clinical epidemiology and disease burden of nonalcoholic fatty liver disease.
Abstract Nonalcoholic fatty liver disease (NAFLD) is defined as the presence of hepatic fat accumulation after the exclusion of other causes of hepatic steatosis, including other causes of liver disease, excessive alcohol consumption, and other conditions that may lead to hepatic steatosis. NAFLD encompasses a broad clinical spectrum ranging from nonalcoholic fatty liver to nonalcoholic steatohepatitis (NASH), advanced fibrosis, cirrhosis, and finally hepatocellular carcinoma (HCC). NAFLD is the most common liver disease in the world and NASH may soon become the most common indication for liver transplantation. On...
Source: World Journal of Gastroenterology : WJG - December 21, 2017 Category: Gastroenterology Authors: Perumpail BJ, Khan MA, Yoo ER, Cholankeril G, Kim D, Ahmed A Tags: World J Gastroenterol Source Type: research

Obese children with fatty liver: Between reality and disease mongering.
Abstract Following the current epidemic of obesity, the worldwide prevalence of nonalcoholic fatty liver disease (NAFLD) has increased with potential serious health implications. While it is established that in adults NAFLD can progress to end-stage liver disease in many cases, the risk of progression during childhood is less well defined. Since most obese children are not adherent to lifestyle modifications and hypocaloric diets, there is a growing number of studies on pharmacological interventions with the risk of disease mongering, the practice of widening the boundaries of illness in order to expand the market...
Source: World Journal of Gastroenterology : WJG - December 21, 2017 Category: Gastroenterology Authors: Ranucci G, Spagnuolo MI, Iorio R Tags: World J Gastroenterol Source Type: research

Procalcitonin in inflammatory bowel disease: Drawbacks and opportunities.
Abstract The measurement of procalcitonin has recently become a mainstay for the diagnosis and therapeutic management of severe bacterial infections, especially those sustained by Gram-negative bacteria. Therefore, the aim of this article is to provide a narrative overview on the potential role of procalcitonin measurement in patients with inflammatory bowel disease (IBD). According to the available scientific literature, the clinical significance of procalcitonin for diagnosing IBD or monitoring disease activity remains elusive, and its association with disease severity is confined to a limited number of case-con...
Source: World Journal of Gastroenterology : WJG - December 21, 2017 Category: Gastroenterology Authors: Lippi G, Sanchis-Gomar F Tags: World J Gastroenterol Source Type: research

Gene mutations in stool from gastric and colorectal neoplasia patients by next-generation sequencing.
CONCLUSION: Our results show that in addition to colorectal neoplasms, mutations can also be assayed from stool specimens of patients with gastric neoplasms. PMID: 29307989 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - December 21, 2017 Category: Gastroenterology Authors: Youssef O, Sarhadi V, Ehsan H, Böhling T, Carpelan-Holmström M, Koskensalo S, Puolakkainen P, Kokkola A, Knuutila S Tags: World J Gastroenterol Source Type: research

Polymorphisms in oxidative pathway related genes and susceptibility to inflammatory bowel disease.
CONCLUSION: Our results suggest that the NOS2A_ (CCTTT)n gene variations may influence IBD susceptibility in the Moroccan population. PMID: 29307990 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - December 21, 2017 Category: Gastroenterology Authors: Senhaji N, Nadifi S, Zaid Y, Serrano A, Rodriguez DAL, Serbati N, Karkouri M, Badre W, Martín J Tags: World J Gastroenterol Source Type: research

Effects of initiating time and dosage of Panax notoginseng on mucosal microvascular injury in experimental colitis.
CONCLUSION: PN repairs vascular injury in experimental colitis via attenuating inflammation and oxidative stress in the colonic mucosa. Efficacy is related to initial administration time and dose. PMID: 29307991 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - December 21, 2017 Category: Gastroenterology Authors: Wang SY, Tao P, Hu HY, Yuan JY, Zhao L, Sun BY, Zhang WJ, Lin J Tags: World J Gastroenterol Source Type: research

Fructo-oligosaccharide intensifies visceral hypersensitivity and intestinal inflammation in a stress-induced irritable bowel syndrome mouse model.
Abstract AIM: To determine whether fructo-oligosaccharide (FOS) affects visceral sensitivity, inflammation, and production of intestinal short-chain fatty acids (SCFA) in an irritable bowel syndrome (IBS) mouse model. METHODS: Mice were randomly assigned to daily oral gavage of saline solution with or without FOS (8 g/kg body weight) for 14 d. Mice were further assigned to receive either daily one-hour water avoidance stress (WAS) or sham-WAS for the first 10 d. After 2 wk, visceral sensitivity was measured by abdominal withdrawal reflex in response to colorectal distension and mucosal inflammation was evalua...
Source: World Journal of Gastroenterology : WJG - December 21, 2017 Category: Gastroenterology Authors: Chen BR, Du LJ, He HQ, Kim JJ, Zhao Y, Zhang YW, Luo L, Dai N Tags: World J Gastroenterol Source Type: research

Morin enhances hepatic Nrf2 expression in a liver fibrosis rat model.
Abstract AIM: To investigate whether morin can reduce hepatic fibrosis by activating the NF-E2-related factor 2 (Nrf2) signaling pathway. METHODS: Twenty male Sprague-Dawley rats were randomly divided into four groups: control group, morin group, carbon tetrachloride (CCl4) group, and morin + CCl4 group. Rats in both the CCl4 and morin + CCl4 groups were injected intraperitoneally with CCl4 at a dose of 2 mL/kg twice a week. Rats in both the morin and morin + CCl4 groups were treated orally with morin at a dose of 50 mg/kg twice a week. Control rats were treated with vehicle only twice a week. At the end-poin...
Source: World Journal of Gastroenterology : WJG - December 21, 2017 Category: Gastroenterology Authors: Sang L, Wang XM, Xu DY, Sang LX, Han Y, Jiang LY Tags: World J Gastroenterol Source Type: research

Circular RNA circ-LDLRAD3 as a biomarker in diagnosis of pancreatic cancer.
Abstract AIM: To analyze the diagnostic value of a circular RNA (circRNA), circ-LDLRAD3, in pancreatic cancer. METHODS: Expression levels of circ-LDLRAD3 were tested in both cells and clinical samples; the latter included 30 paired pancreatic cancer tissues and adjacent non-tumorous tissues, 31 plasma samples from patients with pancreatic cancer, and 31 plasma samples from healthy volunteers. Real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) was performed to measure expression levels of circ-LDLRAD3 in cells and clinical samples; then, the relationship between clinicopathologica...
Source: World Journal of Gastroenterology : WJG - December 21, 2017 Category: Gastroenterology Authors: Yang F, Liu DY, Guo JT, Ge N, Zhu P, Liu X, Wang S, Wang GX, Sun SY Tags: World J Gastroenterol Source Type: research

Rifaximin ameliorates hepatic encephalopathy and endotoxemia without affecting the gut microbiome diversity.
Abstract AIM: To determine the efficacy of rifaximin for hepatic encephalopathy (HE) with the linkage of gut microbiome in decompensated cirrhotic patients. METHODS: Twenty patients (12 men and 8 women; median age, 66.8 years; range, 46-81 years) with decompensated cirrhosis (Child-pugh score> 7) underwent cognitive neuropsychological testing, endotoxin analysis, and fecal microbiome assessment at baseline and after 4 wk of treatment with rifaximin 400 mg thrice a day. HE was determined by serum ammonia level and number connection test (NCT)-A. Changes in whole blood endotoxin activity (EA) was analyzed by...
Source: World Journal of Gastroenterology : WJG - December 21, 2017 Category: Gastroenterology Authors: Kaji K, Takaya H, Saikawa S, Furukawa M, Sato S, Kawaratani H, Kitade M, Moriya K, Namisaki T, Akahane T, Mitoro A, Yoshiji H Tags: World J Gastroenterol Source Type: research

Association between white opaque substance under magnifying colonoscopy and lipid droplets in colorectal epithelial neoplasms.
CONCLUSION: The distribution of lipid droplets may be closely associated with the visibility of WOS under M-NBI colonoscopy, and with histologic grade and depth of tumor invasion. PMID: 29307996 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - December 21, 2017 Category: Gastroenterology Authors: Kawasaki K, Eizuka M, Nakamura S, Endo M, Yanai S, Akasaka R, Toya Y, Fujita Y, Uesugi N, Ishida K, Sugai T, Matsumoto T Tags: World J Gastroenterol Source Type: research

Nomogram based on tumor-associated neutrophil-to-lymphocyte ratio to predict survival of patients with gastric neuroendocrine neoplasms.
Abstract AIM: To assess the predictive value of the tumor-associated neutrophil-to-lymphocyte ratio in terms of the clinical outcomes of patients with gastric neuroendocrine neoplasms after radical surgery. METHODS: Data were retrospectively collected from 142 patients who were diagnosed with gastric neuroendocrine neoplasms and who underwent radical gastrectomy at our department from March 2006 to March 2015. These data were retrospectively analyzed, and a receiver operating characteristic curve analysis was used to identify the optimal value of the tumor-associated neutrophil-to-lymphocyte ratio. Univariate...
Source: World Journal of Gastroenterology : WJG - December 21, 2017 Category: Gastroenterology Authors: Cao LL, Lu J, Lin JX, Zheng CH, Li P, Xie JW, Wang JB, Chen QY, Lin M, Tu RH, Huang CM Tags: World J Gastroenterol Source Type: research

Impact of cigarette smoking on recurrence of hyperlipidemic acute pancreatitis.
CONCLUSION: Smoking is associated with worse RFS and an increased rate of HLAP recurrence. Continued smoking correlates with a compromised survival and smoking cessation should be recommended. PMID: 29307998 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - December 21, 2017 Category: Gastroenterology Authors: Xiang JX, Hu LS, Liu P, Tian BY, Su Q, Ji YC, Zhang XF, Liu XM, Wu Z, Lv Y Tags: World J Gastroenterol Source Type: research

First-week clinical responses to dexlansoprazole 60 mg and esomeprazole 40 mg for the treatment of grades A and B gastroesophageal reflux disease.
CONCLUSION: The overall CSR for GERD patients was similar at days 1-7 for both the dexlansoprazole and esomeprazole groups, although a higher incidence of CSR was observed on day 3 in female patients who received a single dose of dexlansoprazole. PMID: 29307999 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - December 21, 2017 Category: Gastroenterology Authors: Liang CM, Kuo MT, Hsu PI, Kuo CH, Tai WC, Yang SC, Wu KL, Wang HM, Yao CC, Tsai CE, Wang YK, Wang JW, Huang CF, Wu DC, Chuah SK, Taiwan Acid-Related Disease Study Group Tags: World J Gastroenterol Source Type: research

Rate of adverse events of gastroduodenal snare polypectomy for non-flat polyp is low: A prospective and multicenter study.
CONCLUSION: Gastroduodenal polypectomy using prophylactic measures has a rate of AEs small enough to consider this procedure a safe and effective method for polyp resection independently of the polyp size and location. PMID: 29308000 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - December 21, 2017 Category: Gastroenterology Authors: Córdova H, Argüello L, Loras C, Naranjo Rodríguez A, Riu Pons F, Gornals JB, Nicolás-Pérez D, Andújar Murcia X, Hernández L, Santolaria S, Leal C, Pons C, Pérez-Cuadrado-Robles E, García-Bosch O, Papo Berger M, Ulla Rocha JL, Sánchez-Montes C, F Tags: World J Gastroenterol Source Type: research

Chronic kidney disease severely deteriorates the outcome of gastrointestinal bleeding: A meta-analysis.
zapáry L, Hegyi P, Mikó A Abstract AIM: To understand the influence of chronic kidney disease (CKD) on mortality, need for transfusion and rebleeding in gastrointestinal (GI) bleeding patients. METHODS: A systematic search was conducted in three databases for studies on GI bleeding patients with CKD or end-stage renal disease (ESRD) with data on outcomes of mortality, transfusion requirement, rebleeding rate and length of hospitalization (LOH). Calculations were performed with Comprehensive Meta-Analysis software using the random effects model. Heterogeneity was tested by using Cochrane's Q and ...
Source: World Journal of Gastroenterology : WJG - December 21, 2017 Category: Gastroenterology Authors: Hágendorn R, Farkas N, Vincze Á, Gyöngyi Z, Csupor D, Bajor J, Erőss B, Csécsei P, Vasas A, Szakács Z, Szapáry L, Hegyi P, Mikó A Tags: World J Gastroenterol Source Type: research

Disabling portosystemic encephalopathy in a non-cirrhotic patient: Successful endovascular treatment of a giant inferior mesenteric-caval shunt via the left internal iliac vein.
Abstract Hepatic encephalopathy is suspected in non-cirrhotic cases of encephalopathy because the symptoms are accompanied by hyperammonaemia. Some cases have been misdiagnosed as psychiatric diseases and consequently patients hospitalized in psychiatric institutions or geriatric facilities. Therefore, the importance of accurate diagnosis of this disease should be strongly emphasized. A 68-year-old female patient presented to the Emergency Room with confusion, lethargy, nausea and vomiting. Examination disclosed normal vital signs. Neurological examination revealed a minimally responsive woman without apparent foc...
Source: World Journal of Gastroenterology : WJG - December 21, 2017 Category: Gastroenterology Authors: de Martinis L, Groppelli G, Corti R, Moramarco LP, Quaretti P, De Cata P, Rotondi M, Chiovato L Tags: World J Gastroenterol Source Type: research

Wernicke encephalopathy in a patient after liver transplantation: A case report.
Abstract Wernicke encephalopathy (WE) is an acute neurological disorder resulting from vitamin B1 deficiency, which is common in chronic alcoholism and is rare in acute liver failure. So far, there are 2 cases of WE reported after liver transplantation. Here, we report a case of a 45-year-old nonalcoholic male patient who developed psychiatric and neurological disturbance 15 d after receiving orthotopic liver transplantation because of hepatitis B-related cirrhosis and portal hypertension. Brain magnetic resonance imaging (MRI) showed symmetric high-signal intensities in the periaqueductal area. The patient was di...
Source: World Journal of Gastroenterology : WJG - December 21, 2017 Category: Gastroenterology Authors: Xie B, Si ZZ, Tang WT, Qi HZ, Li T Tags: World J Gastroenterol Source Type: research

Silymarin: An option to treat non-alcoholic fatty liver disease.
Abstract We have read with a great interest the review published by Singh et al, on the treatment options in alcoholic and non-alcoholic fatty liver disease, including various new targeted therapies that are currently under investigation. Recently, we described the health effects of the Mediterranean diet associated to an antioxidant complex rich in silymarin, to improve in overweight patients anthropometric parameters, glucose and lipid metabolism and intra-hepatic fat accumulation. PMID: 29309065 [PubMed - indexed for MEDLINE] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - December 21, 2017 Category: Gastroenterology Authors: Colica C, Boccuto L, Abenavoli L Tags: World J Gastroenterol Source Type: research

Relation of the IGF/IGF1R system to autophagy in colitis and colorectal cancer.
zes G Abstract Metabolic syndrome (MetS), as a chronic inflammatory disorder has a potential role in the development of inflammatory and cancerous complications of the colonic tissue. The interaction of DNA damage and inflammation is affected by the insulin-like growth factor 1 receptor (IGF1R) signaling pathway. The IGF1R pathway has been reported to regulate autophagy, as well, but sometimes through a bidirectional context. Targeting the IGF1R-autophagy crosstalk could represent a promising strategy for the development of new antiinflammatory and anticancer therapies, and may help for subjects suffering from Met...
Source: World Journal of Gastroenterology : WJG - December 14, 2017 Category: Gastroenterology Authors: Sipos F, Székely H, Kis ID, Tulassay Z, Műzes G Tags: World J Gastroenterol Source Type: research

Retreatment of patients with treatment failure of direct-acting antivirals: Focus on hepatitis C virus genotype 1b.
Abstract The recent development of direct-acting antiviral agents (DAAs) against hepatitis C virus (HCV) infection could lead to higher sustained virological response (SVR) rates, with shorter treatment durations and fewer adverse events compared with regimens that include interferon. However, a relatively small proportion of patients cannot achieve SVR in the first treatment, including DAAs with or without peginterferon and/or ribavirin. Although retreatment with a combination of DAAs should be conducted for these patients, it is more difficult to achieve SVR when retreating these patients because of resistance-a...
Source: World Journal of Gastroenterology : WJG - December 14, 2017 Category: Gastroenterology Authors: Kanda T, Nirei K, Matsumoto N, Higuchi T, Nakamura H, Yamagami H, Matsuoka S, Moriyama M Tags: World J Gastroenterol Source Type: research