Effect of Sheng-jiang powder on multiple-organ inflammatory injury in acute pancreatitis in rats fed a high-fat diet.
CONCLUSION: Obesity may aggravate the inflammatory reaction and pathological multiple-organ injury in AP rats, and SJP may alleviate multiple-organ inflammatory injury in AP in rats fed a high-fat diet. PMID: 30783372 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2019 Category: Gastroenterology Authors: Miao YF, Kang HX, Li J, Zhang YM, Ren HY, Zhu L, Chen H, Yuan L, Su H, Wan MH, Tang WF Tags: World J Gastroenterol Source Type: research

Preoperative rectosigmoid endoscopic ultrasonography predicts the need for bowel resection in endometriosis.
CONCLUSION: The presence of a rectosigmoid nodule of endometriosis greater than 5.20 mm thick on RS-EUS might predict the need for bowel resection. PMID: 30783373 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2019 Category: Gastroenterology Authors: Desplats V, Vitte RL, du Cheyron J, Roseau G, Fauconnier A, Moryoussef F Tags: World J Gastroenterol Source Type: research

Short- and long-term outcomes of endoscopically treated superficial non-ampullary duodenal epithelial tumors.
CONCLUSION: Our findings suggest that ER provides good long-term outcomes in the patients with SNADETs. EMR is likely to become the safe and reliable treatment for small SNADETs. PMID: 30783374 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 14, 2019 Category: Gastroenterology Authors: Hara Y, Goda K, Dobashi A, Ohya TR, Kato M, Sumiyama K, Mitsuishi T, Hirooka S, Ikegami M, Tajiri H Tags: World J Gastroenterol Source Type: research

Serum hepatitis B virus RNA is a predictor of HBeAg seroconversion and virological response with entecavir treatment in chronic hepatitis B patients.
Abstract BACKGROUND: Characteristics of alterations of serum hepatitis B virus (HBV) RNA in different chronic hepatitis B (CHB) patients still cannot be fully explained. Whether HBV RNA can predict HBeAg seroconversion is still controversial. AIM: To investigate whether HBV RNA can predict virological response or HBeAg seroconversion during entecavir (ETV) treatment when HBV DNA is undetectable. METHODS: The present study evaluated 61 individuals who were diagnosed and treated with long-term ETV monotherapy at the Department of Infectious Diseases of Peking University First Hospital (China) from Septembe...
Source: World Journal of Gastroenterology : WJG - February 14, 2019 Category: Gastroenterology Authors: Luo H, Zhang XX, Cao LH, Tan N, Kang Q, Xi HL, Yu M, Xu XY Tags: World J Gastroenterol Source Type: research

Body-mass index correlates with severity and mortality in acute pancreatitis: A meta-analysis.
gyi P, Hungarian Pancreatic Study Group Abstract BACKGROUND: Obesity rates have increased sharply in recent decades. As there is a growing number of cases in which acute pancreatitis (AP) is accompanied by obesity, we found it clinically relevant to investigate how body-mass index (BMI) affects the outcome of the disease. AIM: To quantify the association between subgroups of BMI and the severity and mortality of AP. METHODS: A meta-analysis was performed using the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Protocols. Three databases (PubMed, EMBASE and the Cochrane Library...
Source: World Journal of Gastroenterology : WJG - February 14, 2019 Category: Gastroenterology Authors: Dobszai D, Mátrai P, Gyöngyi Z, Csupor D, Bajor J, Erőss B, Mikó A, Szakó L, Meczker Á, Hágendorn R, Márta K, Szentesi A, Hegyi P, Hungarian Pancreatic Study Group Tags: World J Gastroenterol Source Type: research

Iron and liver fibrosis: Mechanistic and clinical aspects.
Abstract Liver fibrosis is characterised by excessive deposition of extracellular matrix that interrupts normal liver functionality. It is a pathological stage in several untreated chronic liver diseases such as the iron overload syndrome hereditary haemochromatosis, viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and diabetes. Interestingly, regardless of the aetiology, iron-loading is frequently observed in chronic liver diseases. Excess iron can feed the Fenton reaction to generate unquenchable amounts of free radicals that cause grave cellular and tiss...
Source: World Journal of Gastroenterology : WJG - February 7, 2019 Category: Gastroenterology Authors: Mehta KJ, Farnaud SJ, Sharp PA Tags: World J Gastroenterol Source Type: research

Contribution of ghrelin to functional gastrointestinal disorders' pathogenesis.
Abstract Functional gastrointestinal disorders (FGID) are heterogeneous disorders with a variety of clinical manifestations, primarily defined by signs and symptoms rather than a definite underlying cause. Their pathophysiology remains obscure and, although it is expected to differ according to the specific FGID, disruptions in the brain-gut axis are now thought to be a common denominator in their pathogenesis. The hormone ghrelin is an important component of this axis, exerting a wide repertoire of physiological actions, including regulation of gastrointestinal motility and protection of mucosal tissue. Ghrelin's...
Source: World Journal of Gastroenterology : WJG - February 7, 2019 Category: Gastroenterology Authors: Koutouratsas T, Kalli T, Karamanolis G, Gazouli M Tags: World J Gastroenterol Source Type: research

Functional gastrointestinal disorders and gut-brain axis: What does the future hold?
Abstract Despite their high prevalence, lack of understanding of the exact pathophysiology of the functional gastrointestinal disorders has restricted us to symptomatic diagnostic tools and therapies. Complex mechanisms underlying the disturbances in the bidirectional communication between the gastrointestinal tract and the brain have a vital role in the pathogenesis and are key to our understanding of the disease phenomenon. Although we have come a long way in our understanding of these complex disorders with the help of studies on animals especially rodents, there need to be more studies in humans, especially to...
Source: World Journal of Gastroenterology : WJG - February 7, 2019 Category: Gastroenterology Authors: Mukhtar K, Nawaz H, Abid S Tags: World J Gastroenterol Source Type: research

Effect of adipose-derived mesenchymal stem cells on hepatocellular carcinoma: In vitro inhibition of carcinogenesis.
CONCLUSION: These findings shed new light on a protective and therapeutic role for ADMSCs and their CM in controlling HCC invasiveness and carcinogenesis. PMID: 30774272 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2019 Category: Gastroenterology Authors: Serhal R, Saliba N, Hilal G, Moussa M, Hassan GS, El Atat O, Alaaeddine N Tags: World J Gastroenterol Source Type: research

Claudin-7 gene knockout causes destruction of intestinal structure and animal death in mice.
Abstract BACKGROUND: Claudin-7, one of the important components of cellular tight junctions, is currently considered to be expressed abnormally in colorectal inflammation and colorectal cancer. However, there is currently no effective animal model to study its specific mechanism. Therefore, we constructed three lines of Claudin-7 knockout mice using the Cre/LoxP system. AIM: To determine the function of the tumor suppressor gene Claudin-7 by generating three lines of Claudin-7 gene knockout mice. METHODS: We crossed Claudin-7-floxed mice with CMV-Cre, vil1-Cre, and villin-CreERT2 transgenic mice, and the...
Source: World Journal of Gastroenterology : WJG - February 7, 2019 Category: Gastroenterology Authors: Xu C, Wang K, Ding YH, Li WJ, Ding L Tags: World J Gastroenterol Source Type: research

Zinc deficiency in patients with chronic pancreatitis.
Haas SL Abstract BACKGROUND: Zinc is a key element in numerous proteins and plays an important role in essential cell functions such as defense against free radicals and DNA damage repair. Chronic pancreatitis (CP) is a chronic inflammation with progressive fibrosis of pancreas ultimately resulting in pancreatic exocrine insufficiency (PEI), which is associated with malnutrition. Studies analyzing zinc levels in patients with CP are sparse and lead to conflicting results. AIM: To investigate serum zinc levels in patients with CP of various etiologies. METHODS: Between October 2015 and March 2018, patient...
Source: World Journal of Gastroenterology : WJG - February 7, 2019 Category: Gastroenterology Authors: Vujasinovic M, Hedström A, Maisonneuve P, Valente R, von Horn H, Löhr JM, Haas SL Tags: World J Gastroenterol Source Type: research

Analysis of intrahepatic sarcomatoid cholangiocarcinoma: Experience from 11 cases within 17 years.
CONCLUSION: In patients with s-CCC, early diagnosis through biopsy and aggressive treatment, including surgical resection, are important. PMID: 30774275 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2019 Category: Gastroenterology Authors: Kim DK, Kim BR, Jeong JS, Baek YH Tags: World J Gastroenterol Source Type: research

Hepatocellular carcinoma: Can LI-RADS v2017 with gadoxetic-acid enhancement magnetic resonance and diffusion-weighted imaging improve diagnostic accuracy?
CONCLUSION: LI-RADS v2017 has been successfully applied with gadoxetate-enhanced MRI for patients at high risk for HCC. The addition of DWI significantly increases the diagnostic efficiency for HCC. PMID: 30774276 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2019 Category: Gastroenterology Authors: Zhang T, Huang ZX, Wei Y, Jiang HY, Chen J, Liu XJ, Cao LK, Duan T, He XP, Xia CC, Song B Tags: World J Gastroenterol Source Type: research

Fatigue in children and adolescents with inflammatory bowel disease.
CONCLUSION: Fatigue in pediatric IBD is related to a combination of biological, functional and behavioral factors, which should all be taken into account when managing fatigue. PMID: 30774277 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2019 Category: Gastroenterology Authors: Van de Vijver E, Van Gils A, Beckers L, Van Driessche Y, Moes ND, van Rheenen PF Tags: World J Gastroenterol Source Type: research

Human immunodeficiency virus and hepatotropic viruses co-morbidities as the inducers of liver injury progression.
Abstract Hepatotropic viruses induced hepatitis progresses much faster and causes more liver- related health problems in people co-infected with human immunodeficiency virus (HIV). Although treatment with antiretroviral therapy has extended the life expectancy of people with HIV, liver disease induced by hepatitis B virus (HBV) and hepatitis C virus (HCV) causes significant numbers of non-acquired immune deficiency syndrome (AIDS)-related deaths in co-infected patients. In recent years, new insights into the mechanisms of accelerated fibrosis and liver disease progression in HIV/HCV and HIV/HBV co-infections have ...
Source: World Journal of Gastroenterology : WJG - January 28, 2019 Category: Gastroenterology Authors: Ganesan M, Poluektova LY, Kharbanda KK, Osna NA Tags: World J Gastroenterol Source Type: research

Esophagogastric junction outflow obstruction: Where are we now in diagnosis and management?
Abstract Esophagogastric junction outflow obstruction (EGJOO) is a major motility disorder based on the Chicago Classification of esophageal motility disorders. This entity involves a heterogenous group of underlying etiologies. The diagnosis is reached by performing high-resolution manometry. This reveals evidence of obstruction at the esophagogastric junction, manifested by an elevated integrated relaxation pressure (IRP) above a cutoff value (IRP threshold varies by the manometric technology and catheter used), with preserved peristalsis. Further tests like endoscopy, timed barium esophagram, and cross-sectiona...
Source: World Journal of Gastroenterology : WJG - January 28, 2019 Category: Gastroenterology Authors: Samo S, Qayed E Tags: World J Gastroenterol Source Type: research

Differentiating Crohn's disease from intestinal tuberculosis.
Abstract Differentiating Crohn's disease (CD) and intestinal tuberculosis (ITB) has remained a dilemma for most of the clinicians in the developing world, which are endemic for ITB, and where the disease burden of inflammatory bowel disease is on the rise. Although, there are certain clinical (diarrhea/hematochezia/perianal disease common in CD; fever/night sweats common in ITB), endoscopic (longitudinal/aphthous ulcers common in CD; transverse ulcers/patulous ileocaecal valve common in ITB), histologic (caseating/confluent/large granuloma common in ITB; microgranuloma common in CD), microbiologic (positive stain/...
Source: World Journal of Gastroenterology : WJG - January 28, 2019 Category: Gastroenterology Authors: Kedia S, Das P, Madhusudhan KS, Dattagupta S, Sharma R, Sahni P, Makharia G, Ahuja V Tags: World J Gastroenterol Source Type: research

Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort.
CONCLUSION: In our colorectal cancer cohort, tumor tissue presents a differential COX-2 expression pattern with lower enzymatic activity that can be related to an altered metabolic and proteomic profile. PMID: 30700940 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2019 Category: Gastroenterology Authors: Prieto P, Jaén RI, Calle D, Gómez-Serrano M, Núñez E, Fernández-Velasco M, Martín-Sanz P, Alonso S, Vázquez J, Cerdán S, Peinado MÁ, Boscá L Tags: World J Gastroenterol Source Type: research

Adenoma and advanced neoplasia detection rates increase from 45 years of age.
Abstract BACKGROUND: Colonoscopy is considered a valid primary screening tool for colorectal cancer (CRC). The decreasing risk of CRC observed in patients undergoing colonoscopy is correlated with the adenoma detection rate (ADR). Due to the fact that screening programs usually start from the age of 50, very few data are available on the risk of adenoma between 40 and 49 years. However, the incidence of CRC is increasing in young populations and it is not uncommon in routine practice to detect adenomas or even advanced neoplasia during colonoscopy in patients under 50 years. AIM: To compare the ADR and advanc...
Source: World Journal of Gastroenterology : WJG - January 28, 2019 Category: Gastroenterology Authors: Karsenti D, Tharsis G, Burtin P, Venezia F, Tordjman G, Gillet A, Samama J, Nahon-Uzan K, Cattan P, Cavicchi M Tags: World J Gastroenterol Source Type: research

Feasibility of gastric endoscopic submucosal dissection with continuous low-dose aspirin for patients receiving dual antiplatelet therapy.
CONCLUSION: The bleeding rate with continuous LDA in patients receiving DAPT was not statistically different from that with discontinuous LDA in patients receiving DAPT. Therefore, continuous LDA administration may be acceptable for ESD in patients receiving DAPT, although patients should be carefully monitored for possible bleeding. PMID: 30700942 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2019 Category: Gastroenterology Authors: Harada H, Suehiro S, Murakami D, Nakahara R, Nagasaka T, Ujihara T, Sagami R, Katsuyama Y, Hayasaka K, Amano Y Tags: World J Gastroenterol Source Type: research

Treatment for gastric 'indefinite for neoplasm/dysplasia' lesions based on predictive factors.
Abstract BACKGROUND: Gastric 'indefinite for neoplasm/dysplasia' (IFND) is a borderline lesion that is difficult to diagnose as either regenerative or neoplastic. There is a need for guidance in the identification of a subset of patients, who have an IFND lesion with a higher risk of malignant potential, to enable risk stratification and optimal management. AIM: To determine the clinical and pathologic factors for the accurate diagnosis of gastric IFND lesions. METHODS: In total, 461 gastric lesions diagnosed via biopsy as IFND lesions were retrospectively evaluated. Endoscopic resection (n = 134), surge...
Source: World Journal of Gastroenterology : WJG - January 28, 2019 Category: Gastroenterology Authors: Kwon MJ, Kang HS, Kim HT, Choo JW, Lee BH, Hong SE, Park KH, Jung DM, Lim H, Soh JS, Moon SH, Kim JH, Park HR, Min SK, Seo JW, Choe JY Tags: World J Gastroenterol Source Type: research

Outcomes of endoscopic sphincterotomy vs open choledochotomy for common bile duct stones.
Abstract BACKGROUND: Endoscopic sphincterotomy (EST) for the management of common bile duct stones (CBDS) is used increasingly widely because it is a minimally invasive procedure. However, some clinical practitioners argued that EST may be complicated by post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) and accompanied by a higher recurrence of CBDS than open choledochotomy (OCT). Whether any differences in outcomes exist between these two approaches for treating CBDS has not been thoroughly elucidated to date. AIM: To compare the outcomes of EST vs OCT for the management of CBDS a...
Source: World Journal of Gastroenterology : WJG - January 28, 2019 Category: Gastroenterology Authors: Zhou XD, Chen QF, Zhang YY, Yu MJ, Zhong C, Liu ZJ, Li GH, Zhou XJ, Hong JB, Chen YX Tags: World J Gastroenterol Source Type: research

Endoscopic identification of endoluminal esophageal landmarks for radial and longitudinal orientation and lesion location.
CONCLUSION: This study provides an endoscopic characterization of esophageal landmarks corresponding to the left main bronchus and left atrium, to permit radial and longitudinal orientation and accurate lesion location. PMID: 30700945 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2019 Category: Gastroenterology Authors: Emura F, Gomez-Esquivel R, Rodriguez-Reyes C, Benias P, Preciado J, Wallace M, Giraldo-Cadavid L Tags: World J Gastroenterol Source Type: research

Intestinal permeability after Mediterranean diet and low-fat diet in non-alcoholic fatty liver disease.
CONCLUSION: Mediterranean diet is an effective strategy for treating overweight, visceral obesity and serum transaminase in patients with NAFLD. If the Mediterranean diet can improve intestinal permeability in patients with NAFLD, it deserves further investigation. PMID: 30700946 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2019 Category: Gastroenterology Authors: Biolato M, Manca F, Marrone G, Cefalo C, Racco S, Miggiano GA, Valenza V, Gasbarrini A, Miele L, Grieco A Tags: World J Gastroenterol Source Type: research

Chronic hepatitis B and metabolic risk factors: A call for rigorous longitudinal studies.
Abstract Long-term nucleos(t)ide analogue therapy in chronic hepatitis B virus (HBV) infection is effective in suppressing viral replication and reducing liver-related complications. However, HBV-related liver events can still occur in different patient sub-groups. There is emerging evidence that, similar to chronic hepatitis C virus infection, metabolic risk factors may play a role in the disease process of chronic HBV. While the mechanistic nature of metabolic-HBV interactions remains uncertain, studies in different HBV-infected populations have demonstrated that hepatic steatosis, increased body-mass index, dia...
Source: World Journal of Gastroenterology : WJG - January 21, 2019 Category: Gastroenterology Authors: Seto WK Tags: World J Gastroenterol Source Type: research

Roles of Na+/Ca2+ exchanger 1 in digestive system physiology and pathophysiology.
Abstract The Na+/Ca2+ exchanger (NCX) protein family is a part of the cation/Ca2+ exchanger superfamily and participates in the regulation of cellular Ca2+ homeostasis. NCX1, the most important subtype in the NCX family, is expressed widely in various organs and tissues in mammals and plays an especially important role in the physiological and pathological processes of nerves and the cardiovascular system. In the past few years, the function of NCX1 in the digestive system has received increasing attention; NCX1 not only participates in the healing process of gastric ulcer and gastric mucosal injury but also media...
Source: World Journal of Gastroenterology : WJG - January 21, 2019 Category: Gastroenterology Authors: Liao QS, Du Q, Lou J, Xu JY, Xie R Tags: World J Gastroenterol Source Type: research

Endoscopic resection techniques for colorectal neoplasia: Current developments.
Abstract Endoscopic polypectomy and endoscopic mucosal resection (EMR) are the established treatment standards for colorectal polyps. Current research aims at the reduction of both complication and recurrence rates as well as on shortening procedure times. Cold snare resection is the emerging standard for the treatment of smaller (
Source: World Journal of Gastroenterology : WJG - January 21, 2019 Category: Gastroenterology Authors: Dumoulin FL, Hildenbrand R Tags: World J Gastroenterol Source Type: research

Elastography-based screening for esophageal varices in patients with advanced chronic liver disease.
Abstract Elastography-based liver stiffness measurement (LSM) is a non-invasive tool for estimating liver fibrosis but also provides an estimate for the severity of portal hypertension in patients with advanced chronic liver disease (ACLD). The presence of varices and especially of varices needing treatment (VNT) indicates distinct prognostic stages in patients with compensated ACLD (cACLD). The Baveno VI guidelines suggested a simple algorithm based on LSM 150 G/L for ruling-out VNT in patients with cACLD. These (and other) TE-based LSM cut-offs have been evaluated for VNT screening in different liver disease eti...
Source: World Journal of Gastroenterology : WJG - January 21, 2019 Category: Gastroenterology Authors: Paternostro R, Reiberger T, Bucsics T Tags: World J Gastroenterol Source Type: research

NKX6.3 protects against gastric mucosal atrophy by downregulating β-amyloid production.
CONCLUSION: NKX6.3 inhibits gastric mucosal atrophy by regulating Aβ accumulation and inflammatory reaction in gastric epithelial cells. PMID: 30686901 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 21, 2019 Category: Gastroenterology Authors: Yoon JH, Lee YS, Kim O, Ashktorab H, Smoot DT, Nam SW, Park WS Tags: World J Gastroenterol Source Type: research

Effects of positive acceleration (+Gz stress) on liver enzymes, energy metabolism, and liver histology in rats.
CONCLUSION: Repeated +Gz exposures transiently cause hepatocyte injury and affect liver metabolism and morphological structure. PMID: 30686902 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 21, 2019 Category: Gastroenterology Authors: Shi B, Wang XQ, Duan WD, Tan GD, Gao HJ, Pan YW, Guo QJ, Zhang HY Tags: World J Gastroenterol Source Type: research

Incidence and treatment of mediastinal leakage after esophagectomy: Insights from the multicenter study on mediastinal leaks.
CONCLUSION: The incidence of ML after esophagectomy was high mainly in the TMIE group. However, the general and specific (leak-related) mortality rates were low. Early treatment (surgical or endoscopic) of severe leaks is mandatory to limit related mortality. PMID: 30686903 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 21, 2019 Category: Gastroenterology Authors: Fumagalli U, Baiocchi GL, Celotti A, Parise P, Cossu A, Bonavina L, Bernardi D, de Manzoni G, Weindelmayer J, Verlato G, Santi S, Pallabazzer G, Portolani N, Degiuli M, Reddavid R, de Pascale S Tags: World J Gastroenterol Source Type: research

Predicting gastroesophageal varices through spleen magnetic resonance elastography in pediatric liver fibrosis.
Abstract BACKGROUND: A recent retrospective study confirmed that hepatic stiffness and splenic stiffness measured with magnetic resonance elastography (MRE) are strongly associated with the presence of esophageal varices. In addition, strong correlations have been reported between splenic stiffness values measured with MRE and hepatic venous pressure gradients in animal models. However, most studies have been conducted on adult populations, and previous pediatric MRE studies have only demonstrated the feasibility of MRE in pediatric populations, while the actual clinical application of spleen MRE has been limited....
Source: World Journal of Gastroenterology : WJG - January 21, 2019 Category: Gastroenterology Authors: Yoon H, Shin HJ, Kim MJ, Han SJ, Koh H, Kim S, Lee MJ Tags: World J Gastroenterol Source Type: research

Differential hepatic features presenting in Wilson disease-associated cirrhosis and hepatitis B-associated cirrhosis.
Abstract BACKGROUND: Cirrhosis is a chronic late stage liver disease associated with hepatitis viruses, alcoholism, and metabolic disorders, such as Wilson disease (WD). There are no clear markers or clinical features that define cirrhosis originating from these disparate origins. We hypothesized that cirrhosis is not one disease and cirrhosis of different etiology may have differential clinical hepatic features. AIM: To delineate the liver features between WD-associated cirrhosis and hepatitis B-associated cirrhosis in the Chinese population. METHODS: In this observational study, we reviewed the medical...
Source: World Journal of Gastroenterology : WJG - January 21, 2019 Category: Gastroenterology Authors: Zhong HJ, Sun HH, Xue LF, McGowan EM, Chen Y Tags: World J Gastroenterol Source Type: research

Do patients with gastroesophageal reflux disease and somatoform tendencies benefit from antireflux surgery?
Abstract BACKGROUND: The clinical presentation of gastroesophageal reflux disease (GERD) shows a large symptom variation also in different intensities among patients. As several studies have shown, there is a large overlap in the symptomatic spectrum between proven GERD and other disorders such as dyspepsia, functional heartburn and/or somatoform disorders. AIM: To prospectively evaluate the GERD patients with and without somatoform disorders before and after laparoscopic antireflux surgery. METHODS: In a tertiary referral center for foregut surgery over a period of 3 years patients with GERD, qualifying...
Source: World Journal of Gastroenterology : WJG - January 21, 2019 Category: Gastroenterology Authors: Fuchs HF, Babic B, Fuchs KH, Breithaupt W, Varga G, Musial F Tags: World J Gastroenterol Source Type: research

Role of diet and gut microbiota on colorectal cancer immunomodulation.
Abstract Colorectal cancer (CRC) is one of the most commonly diagnosed cancers, and it is characterized by genetic and epigenetic alterations, as well as by inflammatory cell infiltration among malignant and stromal cells. However, this dynamic infiltration can be influenced by the microenvironment to promote tumor proliferation, survival and metastasis or cancer inhibition. In particular, the cancer microenvironment metabolites can regulate the inflammatory cells to induce a chronic inflammatory response that can be a predisposing condition for CRC retention. In addition, some nutritional components might contrib...
Source: World Journal of Gastroenterology : WJG - January 14, 2019 Category: Gastroenterology Authors: De Almeida CV, de Camargo MR, Russo E, Amedei A Tags: World J Gastroenterol Source Type: research

Current status, problems, and perspectives of non-alcoholic fatty liver disease research.
Abstract Non-alcoholic fatty liver disease (NAFLD) is a major chronic liver disease that can lead to liver cirrhosis, liver cancer, and ultimately death. NAFLD is pathologically classified as non-alcoholic fatty liver (NAFL) or non-alcoholic steatohepatitis (NASH) based on the existence of ballooned hepatocytes, although the states have been known to transform into each other. Moreover, since the detection of ballooned hepatocytes may be difficult with limited biopsied specimens, its clinical significance needs reconsideration. Repeated liver biopsy to assess histological NAFLD activity for therapeutic response is...
Source: World Journal of Gastroenterology : WJG - January 14, 2019 Category: Gastroenterology Authors: Tanaka N, Kimura T, Fujimori N, Nagaya T, Komatsu M, Tanaka E Tags: World J Gastroenterol Source Type: research

Prevention of overuse: A view on upper gastrointestinal endoscopy.
Abstract Many upper gastrointestinal (GI) endoscopies worldwide are performed for inappropriate indications. This overuse of healthcare negatively affects healthcare quality and puts pressure on endoscopy services. Dyspepsia is one of the most common inappropriate indications for upper GI endoscopy as diagnostic yield is low. Reasons for untimely referral are: unfamiliarity with dyspepsia guidelines, uncertainty about etiology of symptoms, and therapy failure. Unfiltered open-access referrals feed upper GI endoscopy overuse. This review highlights strategies applied to diminish use of upper GI endoscopies for dysp...
Source: World Journal of Gastroenterology : WJG - January 14, 2019 Category: Gastroenterology Authors: de Jong JJ, Lantinga MA, Drenth JP Tags: World J Gastroenterol Source Type: research

Adverse events related to colonoscopy: Global trends and future challenges.
Abstract Colonoscopy is a widely used method for diagnosing and treating colonic disease. The number of colonoscopies is increasing worldwide, and concerns about associated adverse events are growing. Large-scale studies using big data for post-colonoscopy complications have been reported. A colon perforation is a severe complication with a relatively high mortality rate. The perforation rate, as reported in large studies (≥ 50,000 colonoscopies) published since 2000, ranges from 0.005-0.085%. The trend in the overall perforation rate in the past 15 years has not changed significantly. Bleeding is a more common...
Source: World Journal of Gastroenterology : WJG - January 14, 2019 Category: Gastroenterology Authors: Kim SY, Kim HS, Park HJ Tags: World J Gastroenterol Source Type: research

Human antigen R mediated post-transcriptional regulation of inhibitors of apoptosis proteins in pancreatic cancer.
Abstract AIM: To determine the association of human antigen R (HuR) and inhibitors of apoptosis proteins (IAP1, IAP2) and prognosis in pancreatic cancer. METHODS: Protein and mRNA expression levels of IAP1, IAP2 and HuR in pancreatic ductal adenocarcinoma (PDAC) were compared with normal pancreatic tissue. The correlations among IAP1/IAP2 and HuR as well as their respective correlations with clinicopathological parameters were analyzed. The Kaplan-Meier method and log-rank tests were used for survival analysis. Immunoprecipitation assay was performed to demonstrate HuR binding to IAP1, IAP2 mRNA. PANC1 cells ...
Source: World Journal of Gastroenterology : WJG - January 14, 2019 Category: Gastroenterology Authors: Lukosiute-Urboniene A, Jasukaitiene A, Silkuniene G, Barauskas V, Gulbinas A, Dambrauskas Z Tags: World J Gastroenterol Source Type: research

Six-long non-coding RNA signature predicts recurrence-free survival in hepatocellular carcinoma.
Abstract BACKGROUND: Recent evidence shows that long non-coding RNAs (lncRNAs) are closely related to hepatogenesis and a few aggressive features of hepatocellular carcinoma (HCC). Increasing studies demonstrate that lncRNAs are potential prognostic factors for HCC. Moreover, several studies reported the combination of lncRNAs for predicting the overall survival (OS) of HCC, but the results varied. Thus, more effort including more accurate statistical approaches is needed for exploring the prognostic value of lncRNAs in HCC. AIM: To develop a robust lncRNA signature associated with HCC recurrence to improve p...
Source: World Journal of Gastroenterology : WJG - January 14, 2019 Category: Gastroenterology Authors: Gu JX, Zhang X, Miao RC, Xiang XH, Fu YN, Zhang JY, Liu C, Qu K Tags: World J Gastroenterol Source Type: research

Biomarker identification and trans-regulatory network analyses in esophageal adenocarcinoma and Barrett's esophagus.
CONCLUSION: After the construction and analyses of the trans-regulatory networks in EAC and BE, the results indicate that COL1A1 and MMP1 could be potential biomarkers for EAC and BE, respectively. PMID: 30670912 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 14, 2019 Category: Gastroenterology Authors: Lv J, Guo L, Wang JH, Yan YZ, Zhang J, Wang YY, Yu Y, Huang YF, Zhao HP Tags: World J Gastroenterol Source Type: research

Submucosal tunneling endoscopic resection: An effective and safe therapy for upper gastrointestinal submucosal tumors originating from the muscularis propria layer.
CONCLUSION: STER is an effective and safe therapy for GI SMTs of the MP layer. Its effectiveness and safety are comparable between SMTs of the esophagus and cardia. PMID: 30670913 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 14, 2019 Category: Gastroenterology Authors: Du C, Chai NL, Ling-Hu EQ, Li ZJ, Li LS, Zou JL, Jiang L, Lu ZS, Meng JY, Tang P Tags: World J Gastroenterol Source Type: research

Novel abdominal negative pressure lavage-drainage system for anastomotic leakage after R0 resection for gastric cancer.
CONCLUSION: Our experience demonstrates that ANPLDS is a feasible management for AL after RG for GC. PMID: 30670914 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 14, 2019 Category: Gastroenterology Authors: Zheng ZF, Lu J, Zhang PY, Xu BB, Zheng CH, Li P, Xie JW, Wang JB, Lin JX, Chen QY, Huang CM Tags: World J Gastroenterol Source Type: research

Increased expression of brain-derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrhea-predominant irritable bowel syndrome.
Abstract BACKGROUND: Visceral hypersensitivity is considered to play a vital role in the pathogenesis of irritable bowel syndrome (IBS). Neurotrophins have drawn much attention in IBS recently. Brain-derived neurotrophic factor (BDNF) was found to mediate visceral hypersensitivity via facilitating sensory nerve growth in pre-clinical studies. We hypothesized that BDNF might play a role in the pathogenesis of diarrhea-predominant IBS (IBS-D). AIM: To investigate BDNF levels in IBS-D patients and its role in IBS-D pathophysiology. METHODS: Thirty-one IBS-D patients meeting the Rome IV diagnostic criteria a...
Source: World Journal of Gastroenterology : WJG - January 14, 2019 Category: Gastroenterology Authors: Zhang Y, Qin G, Liu DR, Wang Y, Yao SK Tags: World J Gastroenterol Source Type: research

Endoscopic foregut surgery and interventions: The future is now. The state-of-the-art and my personal journey.
Abstract In this paper, I reviewed the emerging field of endoscopic surgery and present data supporting the contention that endoscopy can now be used to treat many foregut diseases that have been traditionally treated surgically. Within each topic, the content will progress as follows: "lessons learned", "technical considerations" and "future opportunities". Lessons learned will provide a brief background and update on the most current literature. Technical considerations will include my personal experience, including tips and tricks that I have learned over the years. Finally, future...
Source: World Journal of Gastroenterology : WJG - January 7, 2019 Category: Gastroenterology Authors: Chang KJ Tags: World J Gastroenterol Source Type: research

Hepatitis C virus core protein modulates several signaling pathways involved in hepatocellular carcinoma.
Abstract Hepatocellular carcinoma (HCC) is the fifth most common cancer, and hepatitis C virus (HCV) infection plays a major role in HCC development. The molecular mechanisms by which HCV infection leads to HCC are varied. HCV core protein is an important risk factor in HCV-associated liver pathogenesis and can modulate several signaling pathways involved in cell cycle regulation, cell growth promotion, cell proliferation, apoptosis, oxidative stress and lipid metabolism. The dysregulation of signaling pathways such as transforming growth factor β (TGF-β), vascular endothelial growth factor (VEGF), Wnt/&...
Source: World Journal of Gastroenterology : WJG - January 7, 2019 Category: Gastroenterology Authors: Mahmoudvand S, Shokri S, Taherkhani R, Farshadpour F Tags: World J Gastroenterol Source Type: research

Role of surveillance imaging and endoscopy in colorectal cancer follow-up: Quality over quantity?
Abstract Colorectal cancer (CRC) is a prevalent disease and represents a major cause of morbidity and mortality in the developed world. Intensive post-treatment surveillance is routinely recommended by major expert groups for early stage (II and III) CRC survivors because previous meta-analyses showed a modest, but significant survival benefit. This practice has been recently challenged based on data emerging from several large phase III randomized trials that demonstrated a lack of survival benefit from intensive surveillance strategies. In addition, findings from cost-effectiveness analyses of such an approach a...
Source: World Journal of Gastroenterology : WJG - January 7, 2019 Category: Gastroenterology Authors: Liu SL, Cheung WY Tags: World J Gastroenterol Source Type: research

Initial management for acute lower gastrointestinal bleeding.
Abstract Acute lower gastrointestinal bleeding (LGIB) is a common indication for hospital admission. Patients with LGIB often experience persistent or recurrent bleeding and require blood transfusions and interventions, such as colonoscopic, radiological, and surgical treatments. Appropriate decision-making is needed to initially manage acute LGIB, including emergency hospitalization, timing of colonoscopy, and medication use. In this literature review, we summarize the evidence for initial management of acute LGIB. Assessing various clinical factors, including comorbidities, medication use, presenting symptoms, v...
Source: World Journal of Gastroenterology : WJG - January 7, 2019 Category: Gastroenterology Authors: Aoki T, Hirata Y, Yamada A, Koike K Tags: World J Gastroenterol Source Type: research

Endoscopic trans-esophageal submucosal tunneling surgery: A new therapeutic approach for diseases located around the aorta ventralis.
CONCLUSION: EESTS is a feasible and safe technique for diseases located around the aorta ventralis. PMID: 30643360 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 7, 2019 Category: Gastroenterology Authors: Xiong Y, Chen QQ, Chai NL, Jiao SC, Ling Hu EQ Tags: World J Gastroenterol Source Type: research

Autonomic functions and gastric motility in children with functional abdominal pain disorders.
Abstract BACKGROUND: Abdominal pain-predominant functional gastrointestinal disorders (AP-FGIDs) are the most common cause of recurrent abdominal pain in children. Despite its high prevalence, the underlying pathophysiology of this condition is poorly understood. AIM: To assess the role of gastric dysmotility and autonomic nervous system dysfunction in the pathophysiology of AP-FGIDs. METHODS: One hundred children, fulfilling Rome III criteria for AP-FGIDs, and 50 healthy controls, aged 5 to 12 years, were recruited after obtaining parental consent. All patients were investigated for underlying organic d...
Source: World Journal of Gastroenterology : WJG - January 7, 2019 Category: Gastroenterology Authors: Karunanayake A, Rajindrajith S, de Silva HA, Gunawardena S, Devanarayana NM Tags: World J Gastroenterol Source Type: research