Proton pump inhibitor use increases hepatic encephalopathy risk: A systematic review and meta-analysis.
CONCLUSION: The current evidence indicates that PPI use increases HE risk in patients with liver cirrhosis. Further studies with a large data set and well-designed models are needed to validate our findings. PMID: 31210718 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2019 Category: Gastroenterology Authors: Ma YJ, Cao ZX, Li Y, Feng SY Tags: World J Gastroenterol Source Type: research

Association of proton pump inhibitors with risk of hepatic encephalopathy in advanced liver disease: A meta-analysis.
CONCLUSION: In patients with advanced liver disease, PPI use is associated with an elevated risk of HE. Future large prospective studies are needed to confirm this association. PMID: 31210719 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 7, 2019 Category: Gastroenterology Authors: Tantai XX, Yang LB, Wei ZC, Xiao CL, Chen LR, Wang JH, Liu N Tags: World J Gastroenterol Source Type: research

From 2-dimensional to 3-dimensional: Overcoming dilemmas in intestinal mucosal interpretation.
Abstract The purpose of this review is to provide a definitive account of small intestinal mucosal structure and interpretation. The coeliac lesion has been well known, but not well described to date and this review aims to identify the interpretative difficulties which have arisen over time with the histological assessment of coeliac disease. In early coeliac interpretation, there were significant inaccuracies, particularly surrounding intraepithelial lymphocyte counts and the degree of villous flattening which occurred in the tissue. Many of these interpretive pitfalls are still encountered today, increasing the...
Source: World Journal of Gastroenterology : WJG - May 28, 2019 Category: Gastroenterology Authors: Charlesworth RP, Marsh MN Tags: World J Gastroenterol Source Type: research

Optimizing radiotherapy with immune checkpoint blockade in hepatocellular carcinoma.
Abstract Hepatocellular carcinoma (HCC) is the fifth most common cancer, and its incidence is rapidly increasing in North America and Western Europe as well as South-East Asia. Patients with advanced stage HCC have very poor outcomes; therefore, the discovery of new innovative approaches is urgently needed. Cancer immunotherapy has become a game-changer and revolutionized cancer treatment. A comprehensive understanding of tumor-immune interactions led to the development of immune checkpoint inhibitors (ICIs) as new therapeutic tools, which have been used with great success. Targeting immune checkpoint molecules su...
Source: World Journal of Gastroenterology : WJG - May 28, 2019 Category: Gastroenterology Authors: Choi C, Yoo GS, Cho WK, Park HC Tags: World J Gastroenterol Source Type: research

Contribution of pancreatic enzyme replacement therapy to survival and quality of life in patients with pancreatic exocrine insufficiency.
The objective of this study was to analyze the current evidence for the use of pancreatic enzyme replacement therapy (PERT) in affecting survival and quality of life in patients with pancreatic exocrine insufficiency (PEI). Systematic searches of the literature were performed using the PubMed database. Articles were selected for inclusion if they reported findings from trials assessing the effects of PERT on quality of life, survival, malabsorption, growth parameters (such as height, body weight and body mass index), or gastrointestinal symptoms (such as abdominal pain, stool consistency and flatulence). PERT improved PEI-...
Source: World Journal of Gastroenterology : WJG - May 28, 2019 Category: Gastroenterology Authors: Layer P, Kashirskaya N, Gubergrits N Tags: World J Gastroenterol Source Type: research

Hepatocellular adenoma: An unsolved diagnostic enigma.
Abstract Hepatocellular adenoma (HCA) is a rare benign liver tumour associated with the use of oral contraceptives or other steroid medications which occurs predominantly in young and middle-aged women. Unlike other benign liver tumours, an HCA may be complicated by bleeding and malignant transformation. HCAs have been divided into four subtypes based on molecular and pathological features: hepatocyte nuclear factor 1α-mutated HCA, inflammatory HCA, β-catenin-mutated HCA, and unclassified HCA. β-catenin-mutated HCA has the highest risk of haemorrhage or malignant transformation. In the latest upgra...
Source: World Journal of Gastroenterology : WJG - May 28, 2019 Category: Gastroenterology Authors: Renzulli M, Clemente A, Tovoli F, Cappabianca S, Bolondi L, Golfieri R Tags: World J Gastroenterol Source Type: research

Trimethylamine N-oxide attenuates high-fat high-cholesterol diet-induced steatohepatitis by reducing hepatic cholesterol overload in rats.
CONCLUSION: These data suggest that TMAO may modulate the gut microbiota, inhibit intestinal cholesterol absorption, and ameliorate hepatic ER stress and cell death under cholesterol overload, thereby attenuating HFHC diet-induced steatohepatitis in rats. Further studies are needed to evaluate the influence on CVD and define the safe does of TMAO treatment. PMID: 31171889 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 28, 2019 Category: Gastroenterology Authors: Zhao ZH, Xin FZ, Zhou D, Xue YQ, Liu XL, Yang RX, Pan Q, Fan JG Tags: World J Gastroenterol Source Type: research

Brucea javanica oil emulsion improves the effect of radiotherapy on esophageal cancer cells by inhibiting cyclin D1-CDK4/6 axis.
CONCLUSION: BJOE has a strong anti-cancer effect on esophageal cancer and can be used as a radiosensitizer to promote apoptosis in cancerous esophageal cells via the cyclin D1-cyclin-dependent kinase 4/6 axis. PMID: 31171890 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 28, 2019 Category: Gastroenterology Authors: Qiu ZH, Zhang WW, Zhang HH, Jiao GH Tags: World J Gastroenterol Source Type: research

Interleukin-22 receptor 1 is expressed in multinucleated giant cells: A study on intestinal tuberculosis and Crohn's disease.
Abstract BACKGROUND: It is challenging to distinguish intestinal tuberculosis from Crohn's disease due to dynamic changes in epidemiology and similar clinical characteristics. Recent studies have shown that polymorphisms in genes involved in the interleukin (IL)-23/IL-17 axis may affect intestinal mucosal immunity by affecting the differentiation of Th17 cells. AIM: To investigate the specific single-nucleotide polymorphisms (SNPs) in genes involved in the IL-23/IL-17 axis and possible pathways that affect susceptibility to intestinal tuberculosis and Crohn's disease. METHODS: We analysed 133 patients wi...
Source: World Journal of Gastroenterology : WJG - May 28, 2019 Category: Gastroenterology Authors: Yu ZQ, Wang WF, Dai YC, Chen XC, Chen JY Tags: World J Gastroenterol Source Type: research

Prognostic significance of lymphovascular invasion in colorectal cancer and its association with genomic alterations.
Abstract BACKGROUND: Lymphovascular invasion (LVI) is suggested to be an early and important step in tumor progression toward metastasis, but its prognostic value and genetic mechanisms in colorectal cancer (CRC) have not been well investigated. AIM: To investigate the prognostic value of LVI in CRC and identify the associated genomic alterations. METHODS: We performed a retrospective analysis of 1219 CRC patients and evaluated the prognostic value of LVI for overall survival by the Kaplan-Meier method and multivariate Cox regression analysis. We also performed an array-based comparative genomic hybridiz...
Source: World Journal of Gastroenterology : WJG - May 28, 2019 Category: Gastroenterology Authors: Jiang HH, Zhang ZY, Wang XY, Tang X, Liu HL, Wang AL, Li HG, Tang EJ, Lin MB Tags: World J Gastroenterol Source Type: research

Rational arrangement of measuring shear wave speed in the liver.
Abstract BACKGROUND: Shear wave speed has been widely applied to quantify a degree of liver fibrosis. However, there is no standardized procedure, which makes it difficult to utilize the speed universally. AIM: To provide procedural standardization of shear wave speed measurement. METHODS: Point shear wave elastography (pSWE) was measured in 781 patients, and two-dimensional shear wave elastography (2dSWE) was measured on the same day in 18 cases. Regions-of-interest were placed at 12 sites, and the median and robust coefficient-of-variation (CVR) were calculated. A residual sum-of-square (Σdi 2) w...
Source: World Journal of Gastroenterology : WJG - May 28, 2019 Category: Gastroenterology Authors: Yokoo T, Kanefuji T, Suda T, Nagayama I, Hoshi T, Abe S, Morita S, Kamimura H, Kamimura K, Tsuchiya A, Takamura M, Yagi K, Terai S Tags: World J Gastroenterol Source Type: research

Effect of Blumgart anastomosis in reducing the incidence rate of pancreatic fistula after pancreatoduodenectomy.
CONCLUSION: Surgical method should be a key factor in reducing pancreatic fistula, and Blumgart anastomosis needs further promotion. PMID: 31171894 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 28, 2019 Category: Gastroenterology Authors: Li YT, Zhang HY, Xing C, Ding C, Wu WM, Liao Q, Zhang TP, Zhao YP, Dai MH Tags: World J Gastroenterol Source Type: research

Systematic review: Renin-angiotensin system inhibitors in chemoprevention of hepatocellular carcinoma.
CONCLUSION: In humans, RAS inhibitors - alone or in combination - significantly suppressed the cumulative HCC recurrence, without prolonging patient survival, but some limitations intrinsic to these studies prompt further investigations. PMID: 31171895 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 28, 2019 Category: Gastroenterology Authors: Barone M, Viggiani MT, Losurdo G, Principi M, Leo AD Tags: World J Gastroenterol Source Type: research

Cyst fluid glucose: An alternative to carcinoembryonic antigen for pancreatic mucinous cysts.
Abstract Pancreatic cystic lesions (PCLs) have been increasingly recognized in clinical practice. Although inflammatory cysts (pseudocysts) are the most common PCLs detected by cross-sectional imaging modalities in symptomatic patients in a setting of acute or chronic pancreatitis, incidental pancreatic cysts with no symptoms or history of pancreatitis are usually neoplastic cysts. For these lesions, it is imperative to identify mucinous cysts (intraductal papillary mucinous neoplasms and mucinous cystic neoplasms) due to the risk of their progression to malignancy. However, no single imaging modality alone is suf...
Source: World Journal of Gastroenterology : WJG - May 21, 2019 Category: Gastroenterology Authors: Lopes CV Tags: World J Gastroenterol Source Type: research

Mechanisms of hepatocellular carcinoma progression.
Abstract Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver. It is the second leading cause of cancer-related deaths worldwide, with a very poor prognosis. In the United States, there has been only minimal improvement in the prognosis for HCC patients over the past 15 years. Details of the molecular mechanisms and other mechanisms of HCC progression remain unclear. Consequently, there is an urgent need for better understanding of these mechanisms. HCC is often diagnosed at advanced stages, and most patients will therefore need systemic therapy, with sorafenib being the most common at...
Source: World Journal of Gastroenterology : WJG - May 21, 2019 Category: Gastroenterology Authors: Ogunwobi OO, Harricharran T, Huaman J, Galuza A, Odumuwagun O, Tan Y, Ma GX, Nguyen MT Tags: World J Gastroenterol Source Type: research

Congenital peritoneal encapsulation: A review and novel classification system.
Abstract Congenital peritoneal encapsulation (CPE) is a very rare, congenital condition characterised by the presence of an accessory peritoneal membrane which encases a variable extent of the small bowel. It is unclear how CPE develops, however it is currently understood to be a result of an aberrant adhesion in the peritoneal lining of the physiological hernia in foetal mid-gut development. The condition was first described in 1868, and subsequently there have been only 45 case reports of the phenomenon. No formal, systematised review of CPE has yet been performed, meaning the condition remains poorly understood...
Source: World Journal of Gastroenterology : WJG - May 21, 2019 Category: Gastroenterology Authors: Dave A, McMahon J, Zahid A Tags: World J Gastroenterol Source Type: research

Autoimmune hepatitis and IgG4-related disease.
Abstract IgG4-related disease (IgG4-RD) is a chronic-fibroinflammatory disorder affecting a wide range of organs. Elevation of serum IgG4 concentrations and abundant infiltration of IgG4-expressing plasma cells are key diagnostic features of this autoimmune disease. Although common organ involvement of IgG4-RD includes the salivary glands, pancreas, and bile duct, hepatic involvement is less well established. Recently, five studies identified a subtype of autoimmune hepatitis (AIH), called IgG4-associated AIH (IgG4-AIH). IgG4-AIH is diagnosed based on significant accumulation of IgG4-expressing plasmacytes in the ...
Source: World Journal of Gastroenterology : WJG - May 21, 2019 Category: Gastroenterology Authors: Minaga K, Watanabe T, Chung H, Kudo M Tags: World J Gastroenterol Source Type: research

Electroacupuncture at ST36 modulates gastric motility via vagovagal and sympathetic reflexes in rats.
CONCLUSION: These data suggest that EA at ST36 modulates gastric motility via vagovagal and sympathetic reflexes mediated through M2/3 and β1/2 receptors, respectively. Sympathetic nerve activity mediated through β1/2 receptors is associated with an early delay in modulation of gastric motility by EA at ST36. PMID: 31148903 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 21, 2019 Category: Gastroenterology Authors: Lu MJ, Yu Z, He Y, Yin Y, Xu B Tags: World J Gastroenterol Source Type: research

Risk factors for progression to acute-on-chronic liver failure during severe acute exacerbation of chronic hepatitis B virus infection.
Abstract BACKGROUND: Acute exacerbation in patients with chronic hepatitis B virus (HBV) infection results in different severities of liver injury. The risk factors related to progression to hepatic decompensation (HD) and acute-on-chronic liver failure (ACLF) in patients with severe acute exacerbation (SAE) of chronic HBV infection remain unknown. AIM: To identify risk factors related to progression to HD and ACLF in compensated patients with SAE of chronic HBV infection. METHODS: The baseline characteristics of 164 patients with SAE of chronic HBV infection were retrospectively reviewed. Independent ri...
Source: World Journal of Gastroenterology : WJG - May 21, 2019 Category: Gastroenterology Authors: Yuan L, Zeng BM, Liu LL, Ren Y, Yang YQ, Chu J, Li Y, Yang FW, He YH, Lin SD Tags: World J Gastroenterol Source Type: research

Role of D2 gastrectomy in gastric cancer with clinical para-aortic lymph node metastasis.
CONCLUSION: For gastric cancer patients with radiologically suspicious PALM that responds well to chemotherapy, D2 gastrectomy could be a safe and effective treatment and should be adopted in a MDT approach for gastric cancer with clinical PALM. PMID: 31148905 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 21, 2019 Category: Gastroenterology Authors: Zheng XH, Zhang W, Yang L, Du CX, Li N, Xing GS, Tian YT, Xie YB Tags: World J Gastroenterol Source Type: research

Combined evaluation of biomarkers as predictor of maintained remission in Crohn's disease.
Abstract BACKGROUND: The individual performances and the complementarity of Crohn's disease (CD) activity index (CDAI), C-reactive protein (CRP) and faecal calprotectin (Fcal) to monitor patients with CD remain poorly investigated in the era of "tight control" and "treat to target" strategies. AIM: To assess CDAI, CRP and Fcal variation, alone or combined, after 12 wk (W12) of anti-tumor necrosis factor (TNF) therapy to predict corticosteroids-free remission (CFREM = CDAI 250 μg/g were prospectively enrolled. RESULTS: Among the 40 included patients, 13 patients (32.5%) achieved CFR...
Source: World Journal of Gastroenterology : WJG - May 21, 2019 Category: Gastroenterology Authors: Sollelis E, Quinard RM, Bouguen G, Goutte M, Goutorbe F, Bouvier D, Pereira B, Bommelaer G, Buisson A Tags: World J Gastroenterol Source Type: research

Change in arterial tumor perfusion is an early biomarker of lenvatinib efficacy in patients with unresectable hepatocellular carcinoma.
CONCLUSION: CEUS may be useful for the early prediction of tumor response to lenvatinib therapy in patients with unresectable HCC. PMID: 31148907 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 21, 2019 Category: Gastroenterology Authors: Kuorda H, Abe T, Fujiwara Y, Okamoto T, Yonezawa M, Sato H, Endo K, Oikawa T, Sawara K, Takikawa Y Tags: World J Gastroenterol Source Type: research

New antireflux plastic stent for patients with distal malignant biliary obstruction.
CONCLUSION: The new ARPS is safe and effective for the palliation of unresectable distal MBO, and has a significantly longer stent patency than a TPS. PMID: 31148908 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 21, 2019 Category: Gastroenterology Authors: Yuan XL, Wei B, Ye LS, Wu CC, Tan QH, Yao MH, Zhang YH, Zeng XH, Li Y, Zhang YY, Hu B Tags: World J Gastroenterol Source Type: research

High-risk symptoms and quantitative faecal immunochemical test accuracy: Systematic review and meta-analysis.
lla J Abstract BACKGROUND: The quantitative faecal immunochemical test for haemoglobin (FIT) has been revealed to be highly accurate for colorectal cancer (CRC) detection not only in a screening setting, but also in the assessment of patients presenting lower bowel symptoms. Therefore, the National Institute for Health and Care Excellence has recommended the adoption of FIT in primary care to guide referral for suspected CRC in low-risk symptomatic patients using a 10 µg Hb/g faeces threshold. Nevertheless, it is unknown whether FIT´s accuracy remains stable throughout the broad spectrum of possible sy...
Source: World Journal of Gastroenterology : WJG - May 21, 2019 Category: Gastroenterology Authors: Pin Vieito N, Zarraqui├▒os S, Cubiella J Tags: World J Gastroenterol Source Type: research

Alteration of the esophageal microbiota in Barrett's esophagus and esophageal adenocarcinoma.
Abstract The incidence of esophageal adenocarcinoma (EAC) has increased in recent decades, and its 5-year survival rate is less than 20%. As a well-established precursor, patients with Barrett's esophagus (BE) have a persistent risk of progression to EAC. Many researchers have already identified some factors that may contribute to the development of BE and EAC, and the identified risks include gastroesophageal reflux (GER), male sex, older age, central obesity, tobacco smoking, Helicobacter pylori (H. pylori) eradication, and the administration of proton pump inhibitors (PPIs) and antibiotics. The human gut harbor...
Source: World Journal of Gastroenterology : WJG - May 14, 2019 Category: Gastroenterology Authors: Lv J, Guo L, Liu JJ, Zhao HP, Zhang J, Wang JH Tags: World J Gastroenterol Source Type: research

Inflammatory bowel diseases and spondyloarthropathies: From pathogenesis to treatment.
Abstract Spondyloarthropathies (SpA) include many different forms of inflammatory arthritis and can affect the spine (axial SpA) and/or peripheral joints (peripheral SpA) with Ankylosing spondylitis (AS) being the prototype of the former. Extra-articular manifestations, like uveitis, psoriasis and inflammatory bowel disease (IBD) are frequently observed in the setting of SpA and are, in fact, part of the SpA classification criteria. Bowel involvement seems to be the most common of these manifestations. Clinically evident IBD is observed in 6%-14% of AS patients, which is significantly more frequent compared to the...
Source: World Journal of Gastroenterology : WJG - May 14, 2019 Category: Gastroenterology Authors: Fragoulis GE, Liava C, Daoussis D, Akriviadis E, Garyfallos A, Dimitroulas T Tags: World J Gastroenterol Source Type: research

Harnessing the potential of gene editing technology using CRISPR in inflammatory bowel disease.
Abstract The molecular scalpel of clustered regularly interspersed short palindromic repeats/CRISPR associated protein 9 (CRISPR/Cas9) technology may be sharp enough to begin cutting the genes implicated in inflammatory bowel disease (IBD) and consequently decrease the 6.3 billion dollar annual financial healthcare burden in the treatment of IBD. For the past few years CRISPR technology has drastically revolutionized DNA engineering and biomedical research field. We are beginning to see its application in gene manipulation of sickle cell disease, human immunodeficiency virus resistant embryologic twin gene modific...
Source: World Journal of Gastroenterology : WJG - May 14, 2019 Category: Gastroenterology Authors: Limanskiy V, Vyas A, Chaturvedi LS, Vyas D Tags: World J Gastroenterol Source Type: research

Diversity of Saccharomyces boulardii CNCM I-745 mechanisms of action against intestinal infections.
Abstract The yeast Saccharomyces boulardii CNCM I-745 is one of the probiotics recommended for the prevention of antibiotic-associated diarrhea. Studies conducted in vivo and in vitro demonstrated that in the case of infectious diseases there are two potential sites of action of Saccharomyces boulardii CNCM I-745: (1) An action on enteropathogenic microorganisms (adhesion of bacteria and their elimination or an effect on their virulence factors: Toxins, lipopolysaccharide, etc.); and (2) a direct action on the intestinal mucosa (trophic effects, effects on epithelial reconstitution, anti-secretory effects, anti-in...
Source: World Journal of Gastroenterology : WJG - May 14, 2019 Category: Gastroenterology Authors: Czerucka D, Rampal P Tags: World J Gastroenterol Source Type: research

Characteristics of mucosa-associated gut microbiota during treatment in Crohn's disease.
CONCLUSION: The dysbiosis of mucosa-associated microbiota was associated with the disease phenotype and may become a potential diagnostic tool for the recurrence of disease. PMID: 31143071 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2019 Category: Gastroenterology Authors: He C, Wang H, Liao WD, Peng C, Shu X, Zhu X, Zhu ZH Tags: World J Gastroenterol Source Type: research

Role of abdominal ultrasound for the surveillance follow-up of pancreatic cystic neoplasms: a cost-effective safe alternative to the routine use of magnetic resonance imaging.
In this study, we report on our clinical experience of a follow-up strategy of image-based surveillance with US, and restricted use of MRI every two years and for urgent evaluation whenever suspicious changes are detected by US. AIM: To report the results and cost-efficacy of a US-based surveillance follow-up for known PCNs, with restricted use of MRI. METHODS: We retrospectively evaluated the records of all the patients treated in our institution with non-surgical PCN who received follow-up abdominal US and restricted MRI from the time of diagnosis, between January 2012 and January 2017. After US diagnosis and M...
Source: World Journal of Gastroenterology : WJG - May 14, 2019 Category: Gastroenterology Authors: Morelli L, Guadagni S, Borrelli V, Pisano R, Di Franco G, Palmeri M, Furbetta N, Gambaccini D, Marchi S, Boraschi P, Bastiani L, Campatelli A, Mosca F, Di Candio G Tags: World J Gastroenterol Source Type: research

Ombitasvir/paritaprevir/ritonavir + dasabuvir +/- ribavirin in real world hepatitis C patients.
CONCLUSION: In an all-comers HCV GT1 population, 12 or 24-wk of OBV/PTV/r + DSV +/- RBV is highly effective and tolerable and results in better mental and physical health following treatment. PMID: 31143073 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2019 Category: Gastroenterology Authors: Loo N, Lawitz E, Alkhouri N, Wells J, Landaverde C, Coste A, Salcido R, Scott M, Poordad F Tags: World J Gastroenterol Source Type: research

Nested case-control study on risk factors for opportunistic infections in patients with inflammatory bowel disease.
CONCLUSION: Factors such as severe IBD, elevated levels of fecal calprotectin, and the use of immunosuppressive medications, especially when used in combination, are major risk factors for opportunistic infections in IBD patients. The use of IFX alone does not increase the risk of opportunistic infection. PMID: 31143074 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2019 Category: Gastroenterology Authors: Gong SS, Fan YH, Han QQ, Lv B, Xu Y Tags: World J Gastroenterol Source Type: research

Effect of prophylactic clip placement following endoscopic mucosal resection of large colorectal lesions on delayed polypectomy bleeding: A meta-analysis.
Abstract BACKGROUND: The role of prophylactic clipping for the prevention of delayed polypectomy bleeding (DPB) remains unclear and conclusions from prior meta-analyses are limited due to the inclusion of variety of resection techniques and polyp sizes. AIM: To conduct a meta-analysis on the effect of clipping on DPB following endoscopic mucosal resection (EMR) of colorectal lesions ≥ 20 mm. METHODS: We performed a search of PubMed and the Cochrane library for studies comparing the effect of clipping vs no clipping on DPB following endoscopic resection. The Cochran Q test and I 2 were used to test for...
Source: World Journal of Gastroenterology : WJG - May 14, 2019 Category: Gastroenterology Authors: Ayoub F, Westerveld DR, Forde JJ, Forsmark CE, Draganov PV, Yang D Tags: World J Gastroenterol Source Type: research

Recurrent renal cell carcinoma leading to a misdiagnosis of polycystic liver disease: A case report.
CONCLUSION: This case demonstrates the importance of excluding the cystic metastasis of a cancer when liver cysts are observed. PMID: 31143076 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 14, 2019 Category: Gastroenterology Authors: Liang C, Takahashi K, Kurata M, Sakashita S, Oda T, Ohkohchi N Tags: World J Gastroenterol Source Type: research

Microbial metabolites in non-alcoholic fatty liver disease.
Abstract The prevalence of non-alcoholic fatty liver disease (NAFLD) is rising exponentially worldwide. The spectrum of NAFLD includes non-alcoholic fatty liver, non-alcoholic steatohepatitis, liver cirrhosis, and even hepatocellular carcinoma. Evidence shows that microbial metabolites play pivotal roles in the onset and progression of NAFLD. In this review, we discuss how microbe-derived metabolites, such as short-chain fatty acids, endogenous ethanol, bile acids and so forth, contribute to the pathogenesis of NAFLD. PMID: 31114130 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2019 Category: Gastroenterology Authors: Zhou D, Fan JG Tags: World J Gastroenterol Source Type: research

Recent advances in gastric cancer early diagnosis.
Abstract Gastric cancer (GC) remains an important cause of cancer death worldwide with a high mortality rate due to the fact that the majority of GC cases are diagnosed at an advanced stage when the prognosis is poor and the treatment options are limited. Unfortunately, the existing circulating biomarkers for GC diagnosis and prognosis display low sensitivity and specificity and the GC diagnosis is based only on the invasive procedures such as upper digestive endoscopy. There is a huge need for less invasive or non-invasive tests but also highly specific biomarkers in case of GC. Body fluids such as peripheral blo...
Source: World Journal of Gastroenterology : WJG - May 7, 2019 Category: Gastroenterology Authors: Necula L, Matei L, Dragu D, Neagu AI, Mambet C, Nedeianu S, Bleotu C, Diaconu CC, Chivu-Economescu M Tags: World J Gastroenterol Source Type: research

Evolving screening and surveillance techniques for Barrett's esophagus.
Abstract Barrett's esophagus (BE) is a change in the esophageal lining and is known to be the major precursor lesion for most cases of esophageal adenocarcinoma (EAC). Despite an understanding of its association with BE for many years and the falling incidence rates of squamous cell carcinoma of the esophagus, the incidence for EAC continues to rise exponentially. In association with this rising incidence, if the delay in diagnosis of EAC occurs after the onset of symptoms, then the mortality at 5 years is greater than 80%. Appropriate diagnosis and surveillance strategies are therefore vital for BE. Multiple nove...
Source: World Journal of Gastroenterology : WJG - May 7, 2019 Category: Gastroenterology Authors: Steele D, Baig KKK, Peter S Tags: World J Gastroenterol Source Type: research

Proton pump inhibitor: The dual role in gastric cancer.
Abstract Proton pump inhibitors (PPIs) are one of the most frequently used medications for upper gastrointestinal diseases. However, a number of physicians have raised concern about the serious side effects of long-term use of PPIs, including the development of gastric cancer. Recent epidemiological studies have reported a significant association between long-term PPI intake and the risk of gastric cancer, even after successful Helicobacter pylori eradication. However, the effects of PPIs on the development of pre-malignant conditions such as atrophic gastritis or intestinal metaplasia are not fully known, suggest...
Source: World Journal of Gastroenterology : WJG - May 7, 2019 Category: Gastroenterology Authors: Joo MK, Park JJ, Chun HJ Tags: World J Gastroenterol Source Type: research

Herbs-partitioned moxibustion alleviates aberrant intestinal epithelial cell apoptosis by upregulating A20 expression in a mouse model of Crohn's disease.
In this study, mice with A20 deletion in intestinal epithelial cells (A20IEC-KO) were utilized to establish a Crohn's disease mouse model with 2,4,6-trinitrobenzene sulfonic acid (TNBS) administration, as well as wild-type mice. Mice were randomly divided into normal control (NC), model control (MC), mesalazine (MESA), and HPM groups. The morphology of the colonic mucosa was observed by hematoxylin-eosin staining, and serum endotoxin and apoptosis of epithelial cells were evaluated by enzyme-linked immunosorbent assay and terminal dUTP nick-end labeling assay accordingly. The protein expression levels of A20 and tumor necr...
Source: World Journal of Gastroenterology : WJG - May 7, 2019 Category: Gastroenterology Authors: Zhou J, Wu LY, Chen L, Guo YJ, Sun Y, Li T, Zhao JM, Bao CH, Wu HG, Shi Y Tags: World J Gastroenterol Source Type: research

Analysis of the autophagy gene expression profile of pancreatic cancer based on autophagy-related protein microtubule-associated protein 1A/1B-light chain 3.
CONCLUSION: Three hundred and forty-seven genes associated with autophagy in human pancreatic cancer were concentrated, and a key gene ubiquitin C which is closely related to the occurrence of PNI was determined, suggesting that LC3 may influence the PNI and prognosis of pancreatic cancer through ubiquitin C. PMID: 31114135 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2019 Category: Gastroenterology Authors: Yang YH, Zhang YX, Gui Y, Liu JB, Sun JJ, Fan H Tags: World J Gastroenterol Source Type: research

Clinical value of preoperative methylated septin 9 in Chinese colorectal cancer patients.
CONCLUSION: MSEPT9 analysis may add valuable information to current tumor staging. Serum mSEPT9 in Chinese CRC patients appears to offer promising novel prognostic markers and might be considered for monitoring CRC recurrence. PMID: 31114136 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2019 Category: Gastroenterology Authors: Yang X, Xu ZJ, Chen X, Zeng SS, Qian L, Wei J, Peng M, Wang X, Liu WL, Ma HY, Gong ZC, Yan YL Tags: World J Gastroenterol Source Type: research

Beneficial effect of probiotics supplements in reflux esophagitis treated with esomeprazole: A randomized controlled trial.
CONCLUSION: Esomeprazole combined with probiotics (B. subtilis and E. faecium) have a beneficial effect on RE treatment and patient management. PMID: 31114137 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2019 Category: Gastroenterology Authors: Sun QH, Wang HY, Sun SD, Zhang X, Zhang H Tags: World J Gastroenterol Source Type: research

Transitions of care across hospital settings in patients with inflammatory bowel disease.
CONCLUSION: Transitions of care between secondary care settings are common for patients with IBD. Effective systems of data-sharing and care integration are essential to providing safe and effective care for patients. Geographic and age-related patterns of care transitions identified in this study may be used to guide interventions aimed at improving continuity of care. PMID: 31114138 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2019 Category: Gastroenterology Authors: Warren LR, Clarke JM, Arora S, Barahona M, Arebi N, Darzi A Tags: World J Gastroenterol Source Type: research

Efficacy of Detoxsan ® powder on diarrhea caused by gastrointestinal neuroendocrine tumors.
CONCLUSION: Detoxsan® powder is able to reduce significantly symptoms of NET-related diarrhea in the majority of patients. The duration of taking Detoxsan® powder and its dosage vary individually. PMID: 31114139 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2019 Category: Gastroenterology Authors: Langbein T, Dathe W, Deuerling A, Baum RP Tags: World J Gastroenterol Source Type: research

Tuberculous esophagomediastinal fistula with concomitant mediastinal bronchial artery aneurysm-acute upper gastrointestinal bleeding: A case report.
CONCLUSION: We successfully treated a patient with acute upper GI bleeding due to tuberculous esophagomediastinal fistula and mediastinal bronchial artery aneurysm using transcatheter coil embolization. PMID: 31114140 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 7, 2019 Category: Gastroenterology Authors: Alharbi SR Tags: World J Gastroenterol Source Type: research

Development of Helicobacter pylori treatment: How do we manage antimicrobial resistance?
Abstract Helicobacter pylori (H. pylori) antimicrobial resistance is an urgent, global issue. In 2017, the World Health Organization designated clarithromycin-resistant H. pylori as a high priority bacterium for antibiotic research and development. In addition to clarithromycin, resistance to metronidazole and fluoroquinolones has also increased worldwide. Recent international guidelines for management of H. pylori infection recommend bismuth or non-bismuth quadruple therapy for 14 d as a first-line treatment for H. pylori in areas of high clarithromycin and/or metronidazole resistance. Although these treatment re...
Source: World Journal of Gastroenterology : WJG - April 28, 2019 Category: Gastroenterology Authors: Suzuki S, Esaki M, Kusano C, Ikehara H, Gotoda T Tags: World J Gastroenterol Source Type: research

Organoids of liver diseases: From bench to bedside.
Abstract Understanding the occurrence, development, and treatment of liver diseases is the main goal of hepatopathology research. Liver diseases are not only diverse but also highly heterogeneous among individuals. At present, research on liver diseases is conducted mainly through cell culture, animal models, pathological specimens, etc. However, these methods cannot fully reveal the pathogenic mechanism and therapeutic characteristics of individualized liver diseases. Recent advances in three-dimensional cell culture technology (organoid culture techniques) include pluripotent stem cells and adult stem cells that...
Source: World Journal of Gastroenterology : WJG - April 28, 2019 Category: Gastroenterology Authors: Wu LJ, Chen ZY, Wang Y, Zhao JG, Xie XZ, Chen G Tags: World J Gastroenterol Source Type: research

Upper gastrointestinal tract involvement of pediatric inflammatory bowel disease: A pathological review.
Abstract Upper gastrointestinal (UGI) tract involvement of inflammatory bowel disease (IBD) is commonly seen in pediatric patients. Upper endoscopy is included in the routine workup of children with suspected IBD to enhance the diagnosis and management of these patients. Currently, childhood IBD is classified into ulcerative colitis (UC), atypical UC, Crohn's disease (CD) and IBD unclassified. Histologic confirmation of UGI tract involvement, in particular the presence of epithelioid (non-caseating) granulomas, is helpful in confirming the diagnosis of IBD and its classification. Herein, we reviewed selected IBD-a...
Source: World Journal of Gastroenterology : WJG - April 28, 2019 Category: Gastroenterology Authors: Abuquteish D, Putra J Tags: World J Gastroenterol Source Type: research

Signal transducer and activator of transcription 3 promotes the Warburg effect possibly by inducing pyruvate kinase M2 phosphorylation in liver precancerous lesions.
CONCLUSION: The Warburg effect is initiated in liver precancerous lesions in rats. STAT3 activation promotes the Warburg effect by enhancing the phosphorylation of PKM2 in transformed WB-F344 cells. PMID: 31086462 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2019 Category: Gastroenterology Authors: Bi YH, Han WQ, Li RF, Wang YJ, Du ZS, Wang XJ, Jiang Y Tags: World J Gastroenterol Source Type: research

Immune response pattern varies with the natural history of chronic hepatitis B.
CONCLUSION: Our findings demonstrate the changes in immune response pattern during the natural history of HBV infection. Both NK and T cells are functionally impaired in the IT and IA phases. With the spontaneous clearance of HBeAg and hepatitis B surface antigen decline, NK cell cytokine production and HBV-specific T responses are partially restored in IC phase, and the ENEG phase is dominated by nonantigen-specific T cell responses. PMID: 31086463 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2019 Category: Gastroenterology Authors: Wang WT, Zhao XQ, Li GP, Chen YZ, Wang L, Han MF, Li WN, Chen T, Chen G, Xu D, Ning Q, Zhao XP Tags: World J Gastroenterol Source Type: research