Changes in expression of inhibitory substances in the intramural neurons of the stomach following streptozotocin- induced diabetes in the pig.
CONCLUSION: Our results support the hypothesis that in the course of diabetes, long term episodes of high glucose serum level may influence the chemical phenotyping of enteric neurons. PMID: 28970724 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Bulc M, Palus K, Zielonka Ł, Gajęcka M, Całka J Tags: World J Gastroenterol Source Type: research

HOX transcript antisense intergenic RNA represses E-cadherin expression by binding to EZH2 in gastric cancer.
Abstract AIM: To clarify the mechanisms of HOX transcript antisense intergenic RNA (HOTAIR) in gastric cancer (GC) migration and invasion. METHODS: Quantitative real-time polymerase chain reaction (qPCR) was used to detect the expression level of HOTAIR in GC tissues. The correlation of its expression with clinicopathological features was analyzed. Area under receiver operating characteristic curve (AUCROC) was constructed to evaluate the diagnostic value of HOTAIR. Wound-healing assay and Transwell assay were performed to detect the biological effects of HOTAIR in GC cells. qPCR, western blot and immunohisto...
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Chen WM, Chen WD, Jiang XM, Jia XF, Wang HM, Zhang QJ, Shu YQ, Zhao HB Tags: World J Gastroenterol Source Type: research

Ca(2+)/calmodulin-dependent protein kinase II regulates colon cancer proliferation and migration via ERK1/2 and p38 pathways.
CONCLUSION: Our findings highlight CaMKII as a potential critical mediator in human colon tumor development and metastasis. PMID: 28970726 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Chen W, An P, Quan XJ, Zhang J, Zhou ZY, Zou LP, Luo HS Tags: World J Gastroenterol Source Type: research

Aberrant DNA-PKcs and ERGIC1 expression may be involved in initiation of gastric cancer.
Abstract AIM: To investigate the molecular mechanisms of gastric carcinogenesis. METHODS: We used label-free quantification technology integrated with liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis to identify differentially expressed proteins in 160 specimens of normal gastric mucosa, gastric mucosa with mild dysplasia, moderate dysplasia, severe dysplasia, and early mucosal gastric cancer (GC) collected at the Second Hospital of Lanzhou University from 2010 to 2015. Immunohistochemistry was used to verify the differentially expressed proteins detected by LC-MS/MS. RESULTS: With a th...
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Wang FR, Wei YC, Han ZJ, He WT, Guan XY, Chen H, Li YM Tags: World J Gastroenterol Source Type: research

Real-world treatment patterns of gastrointestinal neuroendocrine tumors: A claims database analysis.
CONCLUSION: In this study, 60% of patients initiated treatment with SSA alone or in combination. The relatively long time to discontinuation suggests possible sustained effectiveness and tolerability. PMID: 28970728 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Benson Iii AB, Broder MS, Cai B, Chang E, Neary MP, Papoyan E Tags: World J Gastroenterol Source Type: research

Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases.
Abstract AIM: To investigate whether immune mediated diseases (IMD) are more frequent in patients with inflammatory bowel disease (IBD). METHODS: In this population based registry study, a total of 47325 patients with IBD were alive and registered in the Danish National Patient Registry on December 16, 2013. Controls were randomly selected from the Danish Civil Registration System (CRS) and matched for sex, age, and municipality. We used ICD 10 codes to identify the diagnoses of the included patients. The IBD population was divided into three subgroups: Ulcerative colitis (UC), Crohn's disease (CD) and Both t...
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Halling ML, Kjeldsen J, Knudsen T, Nielsen J, Hansen LK Tags: World J Gastroenterol Source Type: research

Suspicious brush cytology is an indication for liver transplantation evaluation in primary sclerosing cholangitis.
CONCLUSION: Repeated suspicion of neoplasia in brush cytology should be an indication for evaluations of liver transplantation prior to the development of CCA. PMID: 28970730 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Boyd S, Vannas M, Jokelainen K, Isoniemi H, Mäkisalo H, Färkkilä MA, Arola J Tags: World J Gastroenterol Source Type: research

Management of gastric mucosa-associated lymphoid tissue lymphoma in patients with extra copies of the MALT1 gene.
CONCLUSION: Patients with t(11;18) translocation should be treated differently from others. Patients with extra copies of MALT1 could be initially treated with H. pylori eradication, similar to patients without t(11;18) translocation or extra copies of MALT1. PMID: 28970731 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Iwamuro M, Takenaka R, Nakagawa M, Moritou Y, Saito S, Hori S, Inaba T, Kawai Y, Toyokawa T, Tanaka T, Yoshino T, Okada H Tags: World J Gastroenterol Source Type: research

Ketogenic diet poses a significant effect on imbalanced gut microbiota in infants with refractory epilepsy.
CONCLUSION: GM pattern in healthy infants differed dramatically from that of the epileptic group. KD could significantly modify symptoms of epilepsy and reshape the GM of epileptic infants. PMID: 28970732 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Xie G, Zhou Q, Qiu CZ, Dai WK, Wang HP, Li YH, Liao JX, Lu XG, Lin SF, Ye JH, Ma ZY, Wang WJ Tags: World J Gastroenterol Source Type: research

Definition of colorectal anastomotic leakage: A consensus survey among Dutch and Chinese colorectal surgeons.
CONCLUSION: There is no universally accepted definition of CAL in the Netherlands and China. Diagnosis of CAL based on clinical manifestations remains a point of discussion in both countries. Dutch surgeons are more likely to report 'subclinical' leaks as CAL, which partly explains the higher reported Dutch CAL rates. PMID: 28970733 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: van Rooijen SJ, Jongen AC, Wu ZQ, Ji JF, Slooter GD, Roumen RM, Bouvy ND Tags: World J Gastroenterol Source Type: research

How to treat intestinal obstruction due to malignant recurrence after Whipple's resection for pancreatic head cancer: Description of 2 new endoscopic techniques.
We describe two new endoscopic techniques to treat a malignant intestinal obstruction with the insertion of a SEMS into the afferent limb and the alimentary limb. A case of malignant gastric outlet obstruction after a Whipple's resection was treated by the creation of an endoscopic gastrojejunostomy by the insertion of a lumen apposing HotAxios stent in between the stomach and the alimentary limb under fluoroscopic and endoscopic ultrasound control. Biliary obstruction and jaundice caused by a malignant stricture of the afferent limb after a Roux-en-Y Whipple's resection was treated by the insertion of a SEMS by means of t...
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Mouradides C, Taha A, Borbath I, Deprez PH, Moreels TG Tags: World J Gastroenterol Source Type: research

Arterioportal shunt incidental to treatment with oxaliplatin that mimics recurrent gastric cancer.
Abstract Arterioportal shunt (APS) is an organic communication between the hepatic arterial system and the portal venous system. The APS is one of the major causes of transient hepatic attenuation differences on dynamic computed tomography (CT) or magnetic resonance imaging (MRI). This condition is usually associated with trauma, liver cirrhosis, and malignancies of the liver. However, there has been no report about oxaliplatin-induced APS. A 41-year-old male was diagnosed with Stage IIIB gastric cancer. The patient initially underwent neoadjuvant chemotherapy with capecitabine and oxaliplatin After 3 cycles of th...
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Kim HB, Park SG Tags: World J Gastroenterol Source Type: research

Comment on "Effect of biofilm formation by clinical isolates of Helicobacter pylori on the efflux-mediated resistance to commonly used antibiotics".
In conclusion, we provide additional data regarding the role of specific innate immune molecules in antibiotic cross-resistance mechanisms that may deepen our understanding in the context of the development of novel eradication regimens. PMID: 28970736 [PubMed - indexed for MEDLINE] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Kazakos EI, Dorrell N, Polyzos SA, Deretzi G, Kountouras J Tags: World J Gastroenterol Source Type: research

Role of tissue microenvironment resident adipocytes in colon cancer.
Abstract Colorectal cancer (CRC) is a multifactorial disease characterized by several genetic and epigenetic alterations occurring in epithelial cells. It is increasingly recognized that tumour progression is also regulated by tumour microenvironment (TME). The bidirectional cross-talk between tumour resident adipocytes and cancer cells within TME has been proposed as active contributor to carcinogenesis. Tumour resident adipocytes exhibit an activated phenotype characterized by increased secretion of pro-tumorigenic factors (angiogenic/inflammatory/immune) which contribute to cancer cell proliferation, invasion, ...
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Tabuso M, Homer-Vanniasinkam S, Adya R, Arasaradnam RP Tags: World J Gastroenterol Source Type: research

Ophthalmic manifestations in patients with inflammatory bowel disease: A review.
Abstract Clinical manifestations of inflammatory bowel disease (IBD) are not locally restricted to the gastrointestinal tract, and a significant portion of patients have involvement of other organs and systems. The visual system is one of the most frequently affected, mainly by inflammatory disorders such as episcleritis, uveitis and scleritis. A critical review of available literature concerning ocular involvement in IBD, as it appears in PubMed, was performed. Episcleritis, the most common ocular extraintestinal manifestation (EIM), seems to be more associated with IBD activity when compared with other ocular EI...
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Troncoso LL, Biancardi AL, de Moraes HV, Zaltman C Tags: World J Gastroenterol Source Type: research

Laparoscopic appendectomy for acute appendicitis: How to discourage surgeons using inadequate therapy.
Abstract Acute appendicitis (AA) develops in a progressive and irreversible manner, even if the clinical course of AA can be temporarily modified by intentional medications. Reliable and real-time diagnosis of AA can be made based on findings of the white blood cell count and enhanced computed tomography. Emergent laparoscopic appendectomy (LA) is considered as the first therapeutic choice for AA. Interval/delayed appendectomy at 6-12 wk after disease onset is considered as unsafe with a high recurrent rate during the waiting time. However, this technique may have some advantages for avoiding unnecessary extended ...
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Hori T, Machimoto T, Kadokawa Y, Hata T, Ito T, Kato S, Yasukawa D, Aisu Y, Kimura Y, Sasaki M, Takamatsu Y, Kitano T, Hisamori S, Yoshimura T Tags: World J Gastroenterol Source Type: research

Long non-coding RNAs in hepatocellular carcinoma: Potential roles and clinical implications.
Abstract Long non-coding RNAs (lncRNAs) are a subgroup of non-coding RNA transcripts greater than 200 nucleotides in length with little or no protein-coding potential. Emerging evidence indicates that lncRNAs may play important regulatory roles in the pathogenesis and progression of human cancers, including hepatocellular carcinoma (HCC). Certain lncRNAs may be used as diagnostic or prognostic markers for HCC, a serious malignancy with increasing morbidity and high mortality rates worldwide. Therefore, elucidating the functional roles of lncRNAs in tumors can contribute to a better understanding of the molecular m...
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Niu ZS, Niu XJ, Wang WH Tags: World J Gastroenterol Source Type: research

Nano albumin bound-paclitaxel in pancreatic cancer: Current evidences and future directions.
Abstract Pancreatic cancer (PDAC) is an aggressive and chemoresistant disease, representing the fourth cause of cancer related deaths in western countries. Majority of patients have unresectable, locally advanced or metastatic disease at time of diagnosis and the 5-year survival rate in these conditions is extremely low. For more than a decade gemcitabine has been the cornerstone of metastatic PDAC treatment, although survival benefit was very poor. PDAC cells are surrounded by an intense desmoplastic reaction that may create a barrier to the drugs penetration within the tumor. Recently PDAC stroma has been addres...
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Giordano G, Pancione M, Olivieri N, Parcesepe P, Velocci M, Di Raimo T, Coppola L, Toffoli G, D'Andrea MR Tags: World J Gastroenterol Source Type: research

Comparison between tocotrienol and omeprazole on gastric growth factors in stress-exposed rats.
Abstract AIM: To investigate and compare the effects of tocotrienol and omeprazole on gastric growth factors in rats exposed to water-immersion restraint stress (WIRS). METHODS: Twenty-eight male Wistar rats were randomly assigned to four groups of seven rats. The two control groups were administered vitamin-free palm oil (vehicle) and the two treatment groups were given omeprazole (20 mg/kg) or tocotrienol (60 mg/kg) by oral gavage. After 28 d of treatment, rats from one control group and both treated groups were subjected to WIRS one time for 3.5 h. Gastric lesions were measured and gastric tissues were obt...
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Nur Azlina MF, Qodriyah HMS, Chua KH, Kamisah Y Tags: World J Gastroenterol Source Type: research

(-)-Epigallocatechin-3-gallate enhances poly I:C-induced interferon- λ1 production and inhibits hepatitis C virus replication in hepatocytes.
CONCLUSION: Our observations provide experimental evidence that EGCG has the ability to enhance poly I:C-induced intracellular antiviral innate immunity against HCV replication in hepatocytes. PMID: 28932081 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Wang YZ, Li JL, Wang X, Zhang T, Ho WZ Tags: World J Gastroenterol Source Type: research

Effects and mechanism of adenovirus-mediated phosphatase and tension homologue deleted on chromosome ten gene on collagen deposition in rat liver fibrosis.
Abstract AIM: To evaluate the effects of phosphatase and tension homologue deleted on chromosome ten (PTEN) gene on collagen metabolism in hepatic fibrosis and the underlying mechanisms. METHODS: Rat primary hepatic stellate cells (HSCs) and human LX-2 cells were transfected with adenovirus containing cDNA constructs encoding wild-type PTEN (Ad-PTEN), PTEN mutant G129E gene (Ad-G129E), and RNA interference constructs targeting the PTEN sequence PTEN short hairpin RNA to up-regulate and down-regulate the expression of PTEN. HSCs were assayed using fluorescent microscopy, real-time polymerase chain reaction, an...
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Xie SR, An JY, Zheng LB, Huo XX, Guo J, Shih D, Zhang XL Tags: World J Gastroenterol Source Type: research

Integrating TYMS, KRAS and BRAF testing in patients with metastatic colorectal cancer.
Abstract AIM: To investigate the impact of thymidylate synthase (TYMS), KRAS and BRAF in the survival of metastatic colorectal cancer (mCRC) patients treated with chemotherapy. METHODS: Clinical data were collected retrospectively from records of consecutive patients with mCRC treated with fluoropyrimidine-based chemotherapy from 1/2005 to 1/2007. Formalin-fixed paraffin-embedded tissues were retrieved for analysis. TYMS genotypes were identified with restriction fragment analysis PCR, while KRAS and BRAF mutation status was evaluated using real-time PCR assays. TYMS gene polymorphisms of each of the 3' untra...
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Ntavatzikos A, Spathis A, Patapis P, Machairas N, Peros G, Konstantoudakis S, Leventakou D, Panayiotides IG, Karakitsos P, Koumarianou A Tags: World J Gastroenterol Source Type: research

Characterizing gastrointestinal stromal tumors and evaluating neoadjuvant imatinib by sequencing of endoscopic ultrasound-biopsies.
k R Abstract AIM: To evaluate endoscopic ultrasound (EUS)-guided biopsies for the pretreatment characterization of gastrointestinal stromal tumors (GIST) to personalize the management of patients. METHODS: All patients with lesions suspected to be GIST who were referred for EUS-sampling at a tertiary Swedish center were eligible for inclusion 2006-2015. During the observational study phase (2006-2011), routine fine-needle-aspiration (EUS-FNA) was performed. In 2012-2015, we converted to an interventional, randomized protocol with dual sampling EUS-FNA and fine-needle-biopsy-sampling (EUS-FNB) for all lesions....
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Hedenström P, Nilsson B, Demir A, Andersson C, Enlund F, Nilsson O, Sadik R Tags: World J Gastroenterol Source Type: research

Novel predictors for lymph node metastasis in submucosal invasive colorectal carcinoma.
CONCLUSION: Our results indicate that the tumor budding and the depth multiplied by the width measurements of submucosal invasion can provide important information for patients with SICRC. PMID: 28932085 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Yim K, Won DD, Lee IK, Oh ST, Jung ES, Lee SH Tags: World J Gastroenterol Source Type: research

Changes with aging in gastric biomarkers levels and in biochemical factors associated with Helicobacter pylori infection in asymptomatic Chinese population.
Abstract AIM: To observe changes in gastric biomarker levels with age and effects of Helicobacter pylori (H. pylori) infection in a healthy population, and explore factors associated with gastric biomarkers. METHODS: Three hundred and ninety-five subjects were selected and underwent physical examinations, biochemical tests, and measurement of serum pepsinogen (PG) I and II, gastrin-17 (G-17) and H. pylori antibody levels. Analyses were made by Student's t-test, ANOVA, Pearson's correlation and multiple linear regressions. RESULTS: PGII levels were higher in the ≥ 65-years-old age group (P
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Shan JH, Bai XJ, Han LL, Yuan Y, Sun XF Tags: World J Gastroenterol Source Type: research

Modified Helicobacter test using a new test meal and a (13)C-urea breath test in Helicobacter pylori positive and negative dyspepsia patients on proton pump inhibitors.
CONCLUSION: The new test meal based (13)C-UBT is highly accurate in patients on PPIs and can be used in those unable to stop their PPI treatment. PMID: 28932087 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Tepeš B, Malfertheiner P, Labenz J, Aygen S Tags: World J Gastroenterol Source Type: research

Real time endoscopic ultrasound elastography and strain ratio in the diagnosis of solid pancreatic lesions.
CONCLUSION: Combining elastography to strain ratio increases the accuracy of the differentiation of benign from malignant SPL. PMID: 28932088 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Okasha H, Elkholy S, El-Sayed R, Wifi MN, El-Nady M, El-Nabawi W, El-Dayem WA, Radwan MI, Farag A, El-Sherif Y, Al-Gemeie E, Salman A, El-Sherbiny M, El-Mazny A, Mahdy RE Tags: World J Gastroenterol Source Type: research

Efficacy and safety of sofosbuvir and daclatasvir in treatment of kidney transplantation recipients with hepatitis C virus infection.
CONCLUSION: Sofosbuvir and daclatasvir for treatment of KT recipients with HCV infection are highly efficient and safe. Patients tolerated the medications well, and no serious AEs were observed. Larger prospective cohort studies are needed to validate these results. PMID: 28932089 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Xue Y, Zhang LX, Wang L, Li T, Qu YD, Liu F Tags: World J Gastroenterol Source Type: research

New botanical drug, HL tablet, reduces hepatic fat as measured by magnetic resonance spectroscopy in patients with nonalcoholic fatty liver disease: A placebo-controlled, randomized, phase II trial.
CONCLUSION: HL tablet is effective in reducing HFC without any negative lipid profiles, BMI changes and adverse effects. PMID: 28932090 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Jeong JY, Sohn JH, Baek YH, Cho YK, Kim Y, Kim H Tags: World J Gastroenterol Source Type: research

Randomized clinical trial comparing fixed-time split dosing and split dosing of oral Picosulfate regimen for bowel preparation.
CONCLUSION: A fixed-time split dose regimen with sodium picosulfate is not inferior to a split dose regimen for bowel preparation and equally effective for afternoon colonoscopy. PMID: 28932091 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Jun JH, Han KH, Park JK, Seo HI, Kim YD, Lee SJ, Jun BG, Hwang MS, Park YK, Kim MJ, Cheon GJ Tags: World J Gastroenterol Source Type: research

Systematic review and meta-analysis of colon cleansing preparations in patients with inflammatory bowel disease.
CONCLUSION: In inflammatory bowel disease population, PEG low-volume regimen seems not inferior to PEG high-volume to clean the colon, and yields improved willingness-to-repeat. Further additional research is urgently required to compare contemporary products in this population. PMID: 28932092 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Restellini S, Kherad O, Bessissow T, Ménard C, Martel M, Taheri Tanjani M, Lakatos PL, Barkun AN Tags: World J Gastroenterol Source Type: research

Postoperative inflammation as a possible cause of portal vein thrombosis after irreversible electroporation for locally advanced pancreatic cancer.
We report a case of postoperative PVT in a 54-year-old woman who underwent IRE for locally advanced pancreatic cancer. Drain removal and discharge of the patient from the hospital were scheduled on postoperative day (POD) 7; however, a magnetic resonance imaging scan revealed the presence of PVT. We suspected postoperative inflammation in the pancreas as the main cause of PVT. However, the patient did not undergo any medical treatment because she did not have any clinical symptoms, and she was discharged on POD 8. PMID: 28932093 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Su JJ, Su M, Xu K, Wang PF, Yan L, Lu SC, Gu WQ, Chen YL Tags: World J Gastroenterol Source Type: research

Comment on "Efficacy and adverse events of cold vs hot polypectomy: A meta-analysis".
Comment on "Efficacy and adverse events of cold vs hot polypectomy: A meta-analysis". World J Gastroenterol. 2017 Aug 28;23(32):6007-6008 Authors: Sun HH, Huang SL, Bai Y Abstract This is a comment on a meta-analysis of published studies comparing cold vs hot polypectomy. We believe that the conclusion of this meta-analysis that "cold polypectomy is a time-saving procedure for removing small polyps with markedly similar curability and safety to hot polypectomy" needs more rigorous evidence. PMID: 28932094 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Sun HH, Huang SL, Bai Y Tags: World J Gastroenterol Source Type: research

Direct-acting antiviral agents against hepatitis C virus and lipid metabolism.
Abstract Hepatitis C virus (HCV) infection induces steatosis and is accompanied by multiple metabolic alterations including hyperuricemia, reversible hypocholesterolemia and insulin resistance. Total cholesterol, low-density lipoprotein-cholesterol and triglyceride levels are increased by peginterferon and ribavirin combination therapy when a sustained virologic response (SVR) is achieved in patients with HCV. Steatosis is significantly more common in patients with HCV genotype 3 but interferon-free regimens are not always effective for treating HCV genotype 3 infections. HCV infection increases fatty acid synthas...
Source: World Journal of Gastroenterology : WJG - August 21, 2017 Category: Gastroenterology Authors: Kanda T, Moriyama M Tags: World J Gastroenterol Source Type: research

Liquid biopsy in patients with hepatocellular carcinoma: Circulating tumor cells and cell-free nucleic acids.
Abstract Hepatocellular carcinoma (HCC), with its high incidence and mortality rate, is one of the most common malignant tumors. Despite recent development of a diagnostic and treatment method, the prognosis of HCC remains poor. Therefore, to provide optimal treatment for each patient with HCC, more precise and effective biomarkers are urgently needed which could facilitate a more detailed individualized decision-making during HCC treatment, including the following; risk assessment, early cancer detection, prediction of treatment or prognostic outcome. In the blood of cancer patients, accumulating evidence about c...
Source: World Journal of Gastroenterology : WJG - August 21, 2017 Category: Gastroenterology Authors: Okajima W, Komatsu S, Ichikawa D, Miyamae M, Ohashi T, Imamura T, Kiuchi J, Nishibeppu K, Arita T, Konishi H, Shiozaki A, Morimura R, Ikoma H, Okamoto K, Otsuji E Tags: World J Gastroenterol Source Type: research

Fluctuation of zonulin levels in blood vs stability of antibodies.
This study was conducted to assess the variability or stability of zonulin levels vs IgA and IgG antibodies against zonulin in blood samples from 18 controls at 0, 6, 24 and 30 h after blood draw. We also measured zonulin level as well as zonulin, occludin, vinculin, aquaporin 4 and glial fibrillary acidic protein antibodies in the sera of 30 patients with celiac disease and 30 controls using enzyme-linked immunosorbent assay methodology. RESULTS: The serum zonulin level in 6 out of 18 subjects was low or 2.8 ng/mL and showed significant fluctuation from sample to sample. Comparatively, zonulin antibody measured in al...
Source: World Journal of Gastroenterology : WJG - August 21, 2017 Category: Gastroenterology Authors: Vojdani A, Vojdani E, Kharrazian D Tags: World J Gastroenterol Source Type: research

Effects of albumin/glutaraldehyde glue on healing of colonic anastomosis in rats.
CONCLUSION: Albumin/glutaraldehyde, when applied on colonic anastomoses, promotes their healing in rats. Therefore, the application of protective local agents in colonic anastomoses leads to better outcomes. PMID: 28883693 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 21, 2017 Category: Gastroenterology Authors: Despoudi K, Mantzoros I, Ioannidis O, Cheva A, Antoniou N, Konstantaras D, Symeonidis S, Pramateftakis MG, Kotidis E, Angelopoulos S, Tsalis K Tags: World J Gastroenterol Source Type: research

Cytoplasmic domain of tissue factor promotes liver fibrosis in mice.
CONCLUSION: Tissue factor cytoplasmic domain is involved in TF-PAR-2 signalling initiating hepatic fibrosis and is a potential therapeutic target, as its deletion would not impact coagulation. PMID: 28883694 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 21, 2017 Category: Gastroenterology Authors: Knight V, Lourensz D, Tchongue J, Correia J, Tipping P, Sievert W Tags: World J Gastroenterol Source Type: research

Schistosoma japonicum attenuates dextran sodium sulfate-induced colitis in mice via reduction of endoplasmic reticulum stress.
CONCLUSION: Exposure to S. japonicum attenuated inflammatory response in a DSS-induced colitis model. In addition to the Th1/Th2/Th17 pathway and NF-κB pathway, ER stress was shown to be involved in mitigating inflammation and decreasing apoptosis. Thus, ER stress is a new aspect in elucidating the relationship between helminth infection and inflammatory bowel disease (IBD), which may offer new therapeutic methods for IBD. PMID: 28883695 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 21, 2017 Category: Gastroenterology Authors: Liu Y, Ye Q, Liu YL, Kang J, Chen Y, Dong WG Tags: World J Gastroenterol Source Type: research

Metabolomic profiling for identification of metabolites and relevant pathways for taurine in hepatic stellate cells.
CONCLUSION: This study showed that there were distinct changes in biological metabolites of taurine in HSCs and three differential metabolic pathways including sphingolipid pathway, glutathione pathway and thiamine metabolism pathway might be of key importance in mediating the mechanism of action of taurine in HSCs. PMID: 28883696 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 21, 2017 Category: Gastroenterology Authors: Deng X, Liang XQ, Lu FG, Zhao XF, Fu L, Liang J Tags: World J Gastroenterol Source Type: research

Protective effects of Foeniculum vulgare root bark extract against carbon tetrachloride-induced hepatic fibrosis in mice.
CONCLUSION: Our results indicate that FVRB may be a promising agent against hepatic fibrosis and its possible mechanisms are inhibiting lipid peroxidation and reducing collagen formation in liver tissue of liver fibrosis mice. PMID: 28883697 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 21, 2017 Category: Gastroenterology Authors: Zhang C, Tian X, Zhang K, Li GY, Wang HY, Wang JH Tags: World J Gastroenterol Source Type: research

Hypothesized summative anal physiology score correlates but poorly predicts incontinence severity.
Abstract AIM: To explore the relationship between such a construct and an existing continence score. METHODS: A retrospective study of incontinent patients who underwent anal physiology (AP) was performed. AP results and Cleveland Clinic Continence Scores (CCCS) were extracted. An anal physiology score (APS) was developed using maximum resting pressures (MRP), anal canal length (ACL), internal and external sphincter defects and pudendal terminal motor latency. Univariate associations between each variable, APS and CCCS were assessed. Multiple regression analyses were performed. RESULTS: Of 508 (419 women...
Source: World Journal of Gastroenterology : WJG - August 21, 2017 Category: Gastroenterology Authors: Young CJ, Zahid A, Koh CE, Young JM Tags: World J Gastroenterol Source Type: research

Minor endoscopic sphincterotomy followed by large balloon dilation for large choledocholith treatment.
CONCLUSION: EPLBD with mEST is more effective than EST alone for difficult CBD stone removal, with shorter procedure time and fewer early complications. PMID: 28883699 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 21, 2017 Category: Gastroenterology Authors: Xu XD, Chen B, Dai JJ, Qian JQ, Xu CF Tags: World J Gastroenterol Source Type: research

Diagnostic value of FIB-4, aspartate aminotransferase-to-platelet ratio index and liver stiffness measurement in hepatitis B virus-infected patients with persistently normal alanine aminotransferase.
Abstract AIM: To assess the diagnostic value of FIB-4, aspartate aminotransferase-to-platelet ratio index (APRI), and liver stiffness measurement (LSM) in patients with hepatitis B virus infection who have persistently normal alanine transaminase (PNALT). METHODS: We enrolled 245 patients with chronic hepatitis B: 95 in PNALT group, 86 in intermittently elevated alanine transaminase (PIALT1) group [alanine transaminase (ALT) within 1-2 × upper limit of normal value (ULN)], and 64 in PIALT2 group (ALT> 2 × ULN). All the patients received a percutaneous liver biopsy guided by ultrasonography. LSM...
Source: World Journal of Gastroenterology : WJG - August 21, 2017 Category: Gastroenterology Authors: Tan YW, Zhou XB, Ye Y, He C, Ge GH Tags: World J Gastroenterol Source Type: research

Accuracy of endoscopic ultrasound-guided tissue acquisition in the evaluation of lymph nodes enlargement in the absence of on-site pathologist.
CONCLUSION: EUS-guided tissue acquisition is a highly accurate technique for assessing lymph node enlargement. None of the variables evaluated were associated with diagnostic accuracy. PMID: 28883701 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 21, 2017 Category: Gastroenterology Authors: Chin YK, Iglesias-Garcia J, de la Iglesia D, Lariño-Noia J, Abdulkader-Nallib I, Lázare H, Rebolledo Olmedo S, Dominguez-Muñoz JE Tags: World J Gastroenterol Source Type: research

Doublecortin and CaM kinase-like-1 as an independent prognostic factor in patients with resected pancreatic carcinoma.
Abstract AIM: To elucidate the effect of expression of doublecortin and CaM kinase-like-1 (DCLK1) in patients with pancreatic ductal adenocarcinoma (PDAC). METHODS: Tumor specimens were obtained from 136 patients with pancreatic cancer who had undergone resection without preoperative therapy between January 2000 and December 2013 at the Department of Surgical Oncology, Osaka City University. The resected specimens were analyzed for associations with clinicopathological data, including DCLK1 expression, epithelial mesenchymal transition (EMT) marker expression, and cancer stem cell (CSC) marker expression. Uni...
Source: World Journal of Gastroenterology : WJG - August 21, 2017 Category: Gastroenterology Authors: Nishio K, Kimura K, Amano R, Nakata B, Yamazoe S, Ohira G, Miura K, Kametani N, Tanaka H, Muguruma K, Hirakawa K, Ohira M Tags: World J Gastroenterol Source Type: research

Study to determine guidelines for pediatric colonoscopy.
CONCLUSION: Colonoscopy offers a high diagnostic capability for pediatric patients with gastrointestinal symptoms. The selection of appropriate management the performance of colonoscopy is important in pediatric patients. PMID: 28883703 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 21, 2017 Category: Gastroenterology Authors: Yoshioka S, Takedatsu H, Fukunaga S, Kuwaki K, Yamasaki H, Yamauchi R, Mori A, Kawano H, Yanagi T, Mizuochi T, Ushijima K, Mitsuyama K, Tsuruta O, Torimura T Tags: World J Gastroenterol Source Type: research

Postoperative changes of manometry after restorative proctocolectomy in Korean ulcerative colitis patients.
Abstract AIM: To investigate the changes of postoperative anal sphincter function and bowel frequency in Korean patients with ulcerative colitis (UC). METHODS: A total of 127 patients with UC who underwent restorative proctocolectomy (RPC) during 20 years were retrospectively analyzed. The parameters of anal manometry and bowel frequency were compared according to the 6-mo intervals until 24 mo postoperatively. Manometry was used to measure the maximal squeezing pressure (MSP) and maximal resting pressure (MRP). RESULTS: MSP decreased after surgery until 6 mo (157 to 142 mmHg); thereafter, it improved an...
Source: World Journal of Gastroenterology : WJG - August 21, 2017 Category: Gastroenterology Authors: Oh SH, Yoon YS, Lee JL, Kim CW, Park IJ, Lim SB, Yu CS, Kim JC Tags: World J Gastroenterol Source Type: research

Threonine and tyrosine kinase may serve as a prognostic biomarker for gallbladder cancer.
Abstract AIM: To detect the expression of threonine and tyrosine kinase (TTK) in gallbladder cancer (GBC) specimens and analyze the associations between TTK expression and clinicopathological parameters and clinical prognosis. METHODS: A total of 68 patients with GBC who underwent surgical resection were enrolled in this study. The expression of TTK in GBC tissues was detected by immunohistochemistry. The assessment of TTK expression was conducted using the H-scoring system. H-score was calculated by the multiplication of the overall staining intensity with the percentage of positive cells. The expression of ...
Source: World Journal of Gastroenterology : WJG - August 21, 2017 Category: Gastroenterology Authors: Xie Y, Lin JZ, Wang AQ, Xu WY, Long JY, Luo YF, Shi J, Liang ZY, Sang XT, Zhao HT Tags: World J Gastroenterol Source Type: research

Simple instruments facilitating achievement of transanal total mesorectal excision in male patients.
CONCLUSION: Retrograde taTME with simple customized instruments can achieve high-quality TME, and it might be an effective and economical alternative for male patients with bulky tumors. PMID: 28883706 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 21, 2017 Category: Gastroenterology Authors: Xu C, Song HY, Han SL, Ni SC, Zhang HX, Xing CG Tags: World J Gastroenterol Source Type: research