Role and mechanism of circ-PRKCI in hepatocellular carcinoma.
CONCLUSION: This study explores the role and mechanism of circ-PRKCI in HCC, which provides a new research direction and theoretical basis for the treatment of HCC. PMID: 31086464 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2019 Category: Gastroenterology Authors: Qi SX, Sun H, Liu H, Yu J, Jiang ZY, Yan P Tags: World J Gastroenterol Source Type: research

Comparison of decompression tubes with metallic stents for the management of right-sided malignant colonic obstruction.
CONCLUSION: The bridge to surgery using trans-nasal and trans-anal decompression tubes for right-sided malignant colonic obstruction is safe and may improve long-term outcomes. PMID: 31086465 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2019 Category: Gastroenterology Authors: Suzuki Y, Moritani K, Seo Y, Takahashi T Tags: World J Gastroenterol Source Type: research

Dual energy computed tomography for detection of metastatic lymph nodes in patients with hepatocellular carcinoma.
Abstract BACKGROUND: Regional lymph node metastasis in patients with hepatocellular carcinoma (HCC) is not uncommon, and is often under- or misdiagnosed. Regional lymph node metastasis is associated with a negative prognosis in patients with HCC, and surgical resection of lymph node metastasis is considered feasible and efficacious in improving the survival and prognosis. It is critical to characterize lymph node preoperatively. There is currently no consensus regarding the optimal method for the assessment of regional lymph nodes in patients with HCC. AIM: To evaluate the diagnostic value of single source du...
Source: World Journal of Gastroenterology : WJG - April 28, 2019 Category: Gastroenterology Authors: Zeng YR, Yang QH, Liu QY, Min J, Li HG, Liu ZF, Li JX Tags: World J Gastroenterol Source Type: research

Assessment of chronic radiation proctopathy and radiofrequency ablation treatment follow-up with optical coherence tomography angiography: A pilot study.
CONCLUSION: OCTA visualizes depth-resolved microvascular abnormalities in CRP, allowing assessment of superficial features which are endoscopically visible as well as deeper vasculature which cannot be seen endoscopically. OCTA/OCT of the rectum can be performed in conjunction with, or independently from endoscopy. Further studies are warranted to investigate if OCTA/OCT can elucidate pathophysiology of CRP or improve management. PMID: 31086467 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2019 Category: Gastroenterology Authors: Ahsen OO, Liang K, Lee HC, Wang Z, Fujimoto JG, Mashimo H Tags: World J Gastroenterol Source Type: research

Intra-abdominal desmoid tumors mimicking gastrointestinal stromal tumors - 8 cases: A case report.
CONCLUSION: Intra-abdominal DT should be a differential diagnosis for a new single lesion in patients with GIST. PMID: 31086468 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 28, 2019 Category: Gastroenterology Authors: Kim JH, Ryu MH, Park YS, Kim HJ, Park H, Kang YK Tags: World J Gastroenterol Source Type: research

Repurposing drugs to target nonalcoholic steatohepatitis.
Abstract Nonalcoholic fatty liver disease (NAFLD) is a complex disorder that has evolved in recent years as the leading global cause of chronic liver damage. The main obstacle to better disease management pertains to the lack of approved pharmacological interventions for the treatment of nonalcoholic steatohepatitis (NASH) and NASH-fibrosis-the severe histological forms. Over the past decade, tremendous advances have been made in NAFLD research, resulting in the discovery of disease mechanisms and novel therapeutic targets. Hence, a large number of pharmacological agents are currently being tested for safety and e...
Source: World Journal of Gastroenterology : WJG - April 21, 2019 Category: Gastroenterology Authors: Sookoian S, Pirola CJ Tags: World J Gastroenterol Source Type: research

Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development.
Abstract Pancreatic ductal adenocarcinoma (PDAC) remains a deadly disease with no efficacious treatment options. PDAC incidence is projected to increase, which may be caused at least partially by the obesity epidemic. Significantly enhanced efforts to prevent or intercept this cancer are clearly warranted. Oncogenic KRAS mutations are recognized initiating events in PDAC development, however, they are not entirely sufficient for the development of fully invasive PDAC. Additional genetic alterations and/or environmental, nutritional, and metabolic signals, as present in obesity, type-2 diabetes mellitus, and inflam...
Source: World Journal of Gastroenterology : WJG - April 21, 2019 Category: Gastroenterology Authors: Rozengurt E, Eibl G Tags: World J Gastroenterol Source Type: research

Considerations of elderly factors to manage the complication of liver cirrhosis in elderly patients.
Abstract The aging of the organ function causes sensitivity to the disease progression and need careful consideration for the medical treatment. With the increase of aging population, the opportunity to provide medical treatment for people in very old age is rapidly increasing therefore, the understanding of the various physiological changes of cellular function, size and function of organs are essential for the decision of therapeutic options. Among the various chronic conditions seen in elderly people, we have focused on liver cirrhosis, since despite specific therapeutic options for many of liver diseases inclu...
Source: World Journal of Gastroenterology : WJG - April 21, 2019 Category: Gastroenterology Authors: Kamimura K, Sakamaki A, Kamimura H, Setsu T, Yokoo T, Takamura M, Terai S Tags: World J Gastroenterol Source Type: research

Lysyl oxidase and hypoxia-inducible factor 1 α: biomarkers of gastric cancer.
CONCLUSION: LOX and HIF1α can be used as prognostic and predictive biomarkers for GC. PMID: 31057297 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2019 Category: Gastroenterology Authors: Han YL, Chen L, Qin R, Wang GQ, Lin XH, Dai GH Tags: World J Gastroenterol Source Type: research

Predictive and prognostic implications of 4E-BP1, Beclin-1, and LC3 for cetuximab treatment combined with chemotherapy in advanced colorectal cancer with wild-type KRAS: Analysis from real-world data.
Abstract BACKGROUND: Colorectal cancer (CRC) is one of the main causes of cancer-related deaths in China and around the world. Advanced CRC (ACRC) patients suffer from a low cure rate though treated with targeted therapies. The response rate is about 50% to chemotherapy and cetuximab, a monoclonal antibody targeting epidermal growth factor receptor (EGFR) and used for ACRC with wild-type KRAS. It is important to identify more predictors of cetuximab efficacy to further improve precise treatment. Autophagy, showing a key role in the cancer progression, is influenced by the EGFR pathway. Whether autophagy can predic...
Source: World Journal of Gastroenterology : WJG - April 21, 2019 Category: Gastroenterology Authors: Guo GF, Wang YX, Zhang YJ, Chen XX, Lu JB, Wang HH, Jiang C, Qiu HQ, Xia LP Tags: World J Gastroenterol Source Type: research

Extract of Cycas revoluta Thunb. enhances the inhibitory effect of 5- fluorouracil on gastric cancer cells through the AKT-mTOR pathway.
CONCLUSION: The natural extract of Cycas revoluta Thunb. effectively inhibited gastric cancer cell growth and enhanced the anti-cancer effect of 5-Fu through the AKT-mTOR pathway. PMID: 31057299 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2019 Category: Gastroenterology Authors: Cui XL, Li KJ, Ren HX, Zhang YJ, Liu XD, Bu BG, Wang L Tags: World J Gastroenterol Source Type: research

Unconjugated bilirubin alleviates experimental ulcerative colitis by regulating intestinal barrier function and immune inflammation.
Abstract BACKGROUND: Unconjugated bilirubin (UCB) is generally considered toxic but has gained recent prominence for its anti-inflammatory properties. However, the effects of it on the interaction between intestinal flora and organisms and how it influences immune responses remain unresolved. AIM: To investigate the role of UCB in intestinal barrier function and immune inflammation in mice with dextran-sulfate-sodium-induced colitis. METHODS: Acute colitis was induced by 3% (w/v) dextran sulfate sodium salt in drinking water for 6 d followed by untreated water for 2 d. Concurrently, mice with colitis wer...
Source: World Journal of Gastroenterology : WJG - April 21, 2019 Category: Gastroenterology Authors: Zheng JD, He Y, Yu HY, Liu YL, Ge YX, Li XT, Li X, Wang Y, Guo MR, Qu YL, Qin XF, Jiang MS, Wang XH Tags: World J Gastroenterol Source Type: research

Value of pretransplant albumin-bilirubin score in predicting outcomes after liver transplantation.
Abstract BACKGROUND: Due to the significant shortage of organs and the increasing number of candidates on the transplant waiting list, there is an urgent need to identify patients who are most likely to benefit from liver transplantation. The albumin-bilirubin (ALBI) grading system was recently developed to identify patients at risk for adverse outcomes after hepatectomy. However, the value of the pretransplant ALBI score in predicting outcomes after liver transplantation has not been assessed. AIM: To retrospectively investigate the value of the pretransplant ALBI score in predicting outcomes after liver tra...
Source: World Journal of Gastroenterology : WJG - April 21, 2019 Category: Gastroenterology Authors: Ma T, Li QS, Wang Y, Wang B, Wu Z, Lv Y, Wu RQ Tags: World J Gastroenterol Source Type: research

Mechanism of exosomal microRNA-224 in development of hepatocellular carcinoma and its diagnostic and prognostic value.
CONCLUSION: Exosomal miR-224 is a tumor promotor and can be a marker of diagnosis and prognosis of HCC patients, however, its ability to distinguish liver diseases needs further verification. PMID: 31057302 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2019 Category: Gastroenterology Authors: Cui Y, Xu HF, Liu MY, Xu YJ, He JC, Zhou Y, Cang SD Tags: World J Gastroenterol Source Type: research

Colon perforation due to antigenemia-negative cytomegalovirus gastroenteritis after liver transplantation: A case report and review of literature.
CONCLUSION: This case report suggests a monitoring method that could be useful for AG-negative CMV gastroenteritis after a solid-organ transplantation. PMID: 31057303 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 21, 2019 Category: Gastroenterology Authors: Yokose T, Obara H, Shinoda M, Nakano Y, Kitago M, Yagi H, Abe Y, Yamada Y, Matsubara K, Oshima G, Hori S, Ibuki S, Higashi H, Masuda Y, Hayashi M, Mori T, Kawaida M, Fujimura T, Hoshino K, Kameyama K, Kuroda T, Kitagawa Y Tags: World J Gastroenterol Source Type: research

Precision surgical approach with lymph-node dissection in early gastric cancer.
Abstract The gravest prognostic factor in early gastric cancer is lymph-node metastasis, with an incidence of about 10% overall. About two-thirds of early gastric cancer patients can be diagnosed as node-negative prior to treatment based on clinic-pathological data. Thus, the tumor can be resected by endoscopic submucosal dissection. In the remaining third, surgical resection is necessary because of the possibility of nodal metastasis. Nevertheless, almost all patients can be cured by gastrectomy with D1+ lymph-node dissection. Laparoscopic or robotic gastrectomy has become widespread in East Asia because perioper...
Source: World Journal of Gastroenterology : WJG - April 14, 2019 Category: Gastroenterology Authors: Kinami S, Nakamura N, Tomita Y, Miyata T, Fujita H, Ueda N, Kosaka T Tags: World J Gastroenterol Source Type: research

Update on hepatocellular carcinoma: Pathologists' review.
Abstract Histopathologic diversity and several distinct histologic subtypes of hepatocellular carcinoma (HCC) are well-recognized. Recent advances in molecular pathology and growing knowledge about the biology associated with distinct histologic features and immuno-profile in HCC allowed pathologists to update classifications. Improving sub-classification will allow for more clinically relevant diagnoses and may allow for stratification into biologically meaningful subgroups. Therefore, immuno-histochemical and molecular testing are not only diagnostically useful, but also are being incorporated as crucial compone...
Source: World Journal of Gastroenterology : WJG - April 14, 2019 Category: Gastroenterology Authors: El Jabbour T, Lagana SM, Lee H Tags: World J Gastroenterol Source Type: research

Application of artificial intelligence in gastroenterology.
Abstract Artificial intelligence (AI) using deep-learning (DL) has emerged as a breakthrough computer technology. By the era of big data, the accumulation of an enormous number of digital images and medical records drove the need for the utilization of AI to efficiently deal with these data, which have become fundamental resources for a machine to learn by itself. Among several DL models, the convolutional neural network showed outstanding performance in image analysis. In the field of gastroenterology, physicians handle large amounts of clinical data and various kinds of image devices such as endoscopy and ultras...
Source: World Journal of Gastroenterology : WJG - April 14, 2019 Category: Gastroenterology Authors: Yang YJ, Bang CS Tags: World J Gastroenterol Source Type: research

Clinical significance of programmed death 1/programmed death ligand 1 pathway in gastric neuroendocrine carcinomas.
CONCLUSION: Our data demonstrated for the first time that high expression of PD-L1 in G-NECs is associated with a poor prognosis, while the high expression may be due to the copy number variation of PD-L1 gene or stimulation of TILs. These results provide a basis for the immunotherapy targeting PD-1/PD-L1 pathway in G-NECs. PMID: 31011254 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 14, 2019 Category: Gastroenterology Authors: Yang MW, Fu XL, Jiang YS, Chen XJ, Tao LY, Yang JY, Huo YM, Liu W, Zhang JF, Liu PF, Liu Q, Hua R, Zhang ZG, Sun YW, Liu DJ Tags: World J Gastroenterol Source Type: research

Functional role of long non-coding RNA CASC19/miR-140-5p/CEMIP axis in colorectal cancer progression in vitro.
Abstract BACKGROUND: Long non-coding RNAs (lncRNAs) are widely involved in tumor regulation. Nevertheless, the role of the lncRNA cancer susceptibility 19 (CASC19) in colorectal cancer (CRC) has yet to be fully clarified. AIM: To explore the effect of CASC19 on proliferation and metastasizing ability of CRC cells. METHODS: CASC19 expression in human CRC tissues, pair-matched adjacent normal colon tissues, and CRC cells was detected using quantitative real-time PCR (qRT-PCR). CASC19 expression, as well as its relation to overall survival, was extrapolated by Kaplan-Meier survival analysis together with mu...
Source: World Journal of Gastroenterology : WJG - April 14, 2019 Category: Gastroenterology Authors: Wang XD, Lu J, Lin YS, Gao C, Qi F Tags: World J Gastroenterol Source Type: research

Seven-senescence-associated gene signature predicts overall survival for Asian patients with hepatocellular carcinoma.
CONCLUSION: We developed a seven-SAG signature, which could predict OS of Asian HCC patients. This risk model provides new clinical evidence for the accurate diagnosis and targeted treatment of HCC. PMID: 31011256 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 14, 2019 Category: Gastroenterology Authors: Xiang XH, Yang L, Zhang X, Ma XH, Miao RC, Gu JX, Fu YN, Yao Q, Zhang JY, Liu C, Lin T, Qu K Tags: World J Gastroenterol Source Type: research

Chronic functional constipation is strongly linked to vitamin D deficiency.
Abstract BACKGROUND: Few studies have examined intestinal motility disorders, which are disabling conditions associated with chronic functional constipation, whose pathogenesis is actually not well-defined. AIM: To investigate the relationship between serum 25-hydroxyvitamin D levels and functional chronic constipation associated to intestinal motility disorders. METHODS: We performed a prospective case-control study, from May-June to November 2017. Glucose/lactulose breath tests, radiopaque markers (multiple capsule techniques) and wireless motility capsule analysis were used to assess colonic and oro-c...
Source: World Journal of Gastroenterology : WJG - April 14, 2019 Category: Gastroenterology Authors: Panarese A, Pesce F, Porcelli P, Riezzo G, Iacovazzi PA, Leone CM, De Carne M, Rinaldi CM, Shahini E Tags: World J Gastroenterol Source Type: research

Clinical characteristics of non-alcoholic fatty liver disease in Chinese adult hypopituitary patients.
CONCLUSION: NAFLD is common in patients with hypopituitarism. Plasma osmolality and serum sodium levels of hypopituitary patients with cirrhosis are higher than those of subjects with NAFLD, and fasting insulin concentration is positively associated with plasma osmolality in patients with NAFLD, which suggests that hyperosmolality might be a contributor to the worsening of NAFLD in hypopituitary patients. PMID: 31011258 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 14, 2019 Category: Gastroenterology Authors: Yuan XX, Zhu HJ, Pan H, Chen S, Liu ZY, Li Y, Wang LJ, Lu L, Yang HB, Gong FY Tags: World J Gastroenterol Source Type: research

Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations.
Abstract BACKGROUND: We recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with SLCO2A1 gene (CEAS). Crohn's disease (CD) is a major differential diagnosis of CEAS, because these diseases share some clinical features. Therefore, there is a need to develop a convenient screening test to distinguish CEAS from CD. AIM: To examine whether prostaglandin E major urinary metabolites (PGE-MUM) can serve as a biomarker to distinguish CEAS from CD. METHODS: This was a transactional study of 20 patients with CEA...
Source: World Journal of Gastroenterology : WJG - April 14, 2019 Category: Gastroenterology Authors: Matsuno Y, Umeno J, Esaki M, Hirakawa Y, Fuyuno Y, Okamoto Y, Hirano A, Yasukawa S, Hirai F, Matsui T, Hosomi S, Watanabe K, Hosoe N, Ogata H, Hisamatsu T, Yanai S, Kochi S, Kurahara K, Yao T, Torisu T, Kitazono T, Matsumoto T Tags: World J Gastroenterol Source Type: research

Endoscopic response to tumor necrosis factor inhibitors predicts long term benefits in Crohn's disease.
ute;s J, Ordás I Abstract BACKGROUND: Identifying predictors of therapeutic response is the cornerstone of personalized medicine. AIM: To identify predictors of long-term mucosal healing (MH) in patients with Crohn's disease (CD) treated with tumor necrosis factor α (TNF-α) inhibitors. METHODS: Prospective single center study. Consecutive patients with clinically active CD requiring treatment with a TNF-α inhibitor were included. A baseline segmental CD Endoscopic Index of Severity (CDEIS) ≥ 10 in at least one segment or the presence of ulcerations were required for inclusion....
Source: World Journal of Gastroenterology : WJG - April 14, 2019 Category: Gastroenterology Authors: Alfaro I, Masamunt MC, Planell N, López-García A, Castro J, Gallego M, Barastegui R, Giner A, Vara A, Salas A, Ricart E, Panés J, Ordás I Tags: World J Gastroenterol Source Type: research

Application of a 3D-printed "fistula stent" in plugging enteroatmospheric fistula with open abdomen: A case report.
CONCLUSION: Application of this novel "fistula stent" resulted in a drastic reduction in the amount of lost enteric effluent and greatly accelerated rehabilitation processes. PMID: 31011261 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 14, 2019 Category: Gastroenterology Authors: Xu ZY, Ren HJ, Huang JJ, Li ZA, Ren JA Tags: World J Gastroenterol Source Type: research

Comprehensive and innovative techniques for laparoscopic choledocholithotomy: A surgical guide to successfully accomplish this advanced manipulation.
Abstract Surgeries for benign diseases of the extrahepatic bile duct (EHBD) are classified as lithotomy (i.e., choledocholithotomy) or diversion (i.e., choledochojejunostomy). Because of technical challenges, laparoscopic approaches for these surgeries have not gained worldwide popularity. The right upper quadrant of the abdomen is advantageous for laparoscopic procedures, and laparoscopic choledochojejunostomy is safe and feasible. Herein, we summarize tips and pitfalls in the actual procedures of choledocholithotomy. Laparoscopic choledocholithotomy with primary closure of the transductal incision and transcysti...
Source: World Journal of Gastroenterology : WJG - April 7, 2019 Category: Gastroenterology Authors: Hori T Tags: World J Gastroenterol Source Type: research

Hepatocellular carcinoma surveillance: An evidence-based approach.
Abstract Hepatocellular carcinoma (HCC) makes up 75%-85% of all primary liver cancers and is the fourth most common cause of cancer related death worldwide. Chronic liver disease is the most significant risk factor for HCC with 80%-90% of new cases occurring in the background of cirrhosis. Studies have shown that early diagnosis of HCC through surveillance programs improve prognosis and availability of curative therapies. All patients with cirrhosis and high-risk hepatitis B patients are at risk for HCC and should undergo surveillance. The recommended surveillance modality is abdominal ultrasound (US) given that i...
Source: World Journal of Gastroenterology : WJG - April 7, 2019 Category: Gastroenterology Authors: Harris PS, Hansen RM, Gray ME, Massoud OI, McGuire BM, Shoreibah MG Tags: World J Gastroenterol Source Type: research

Cellular therapy: A promising tool in the future of colorectal surgery.
This article reviews the possible mechanisms of action and clinical utility of MSCs and BM-MNCs in promotion of healing and suppression of tumor growth in light of the published literature. Cellular therapy has a potentially important role in colorectal surgery, particularly in the promotion of wound healing and management of metastatic CRC. Future directions of cellular therapy in colorectal surgery were explored which may help stimulate futures studies on the role of cellular therapy in colorectal surgery. PMID: 30983816 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2019 Category: Gastroenterology Authors: El-Said MM, Emile SH Tags: World J Gastroenterol Source Type: research

Characterization of hepatitis B virus X gene quasispecies complexity in mono-infection and hepatitis delta virus superinfection.
M, Rodríguez-Frías F Abstract BACKGROUND: Hepatitis delta virus (HDV) seems to strongly suppress hepatitis B virus (HBV) replication, although little is known about the mechanism of this interaction. Both these viruses show a dynamic distribution of mutants, resulting in viral quasispecies. Next-generation sequencing is a viable approach for analyzing the composition of these mutant spectra. As the regulatory hepatitis B X protein (HBx) is essential for HBV replication, determination of HBV X gene (HBX) quasispecies complexity in HBV/HDV infection compared to HBV mono-infection may provide informati...
Source: World Journal of Gastroenterology : WJG - April 7, 2019 Category: Gastroenterology Authors: Godoy C, Tabernero D, Sopena S, Gregori J, Cortese MF, González C, Casillas R, Yll M, Rando A, López-Martínez R, Quer J, González-Aseguinolaza G, Esteban R, Riveiro-Barciela M, Buti M, Rodríguez-Frías F Tags: World J Gastroenterol Source Type: research

Plasma microRNAs as potential new biomarkers for early detection of early gastric cancer.
We examined the differentially expressed miRNAs in the plasma of 30 patients with EGC, AGC, and BG by miRNA chip analysis. Then, we analyzed and selected the significantly different miRNAs using bioinformatics. Reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) confirmed the relative transcription level of these miRNAs in another 122 patients, including patients with EGC, AGC, Helicobacter pylori (H. pylori)-negative gastritis (Control-1), and H. pylori-positive atrophic gastritis (Control-2). To establish a diagnostic model for the detection of plasma miRNA in EGC, we chose miRNAs that can be...
Source: World Journal of Gastroenterology : WJG - April 7, 2019 Category: Gastroenterology Authors: Zhu XL, Ren LF, Wang HP, Bai ZT, Zhang L, Meng WB, Zhu KX, Ding FH, Miao L, Yan J, Wang YP, Liu YQ, Zhou WC, Li X Tags: World J Gastroenterol Source Type: research

Comparison of Hemospray ® and Endoclot™ for the treatment of gastrointestinal bleeding.
CONCLUSION: Both HP allow for effective hemostasis with no differences in ST, LT success and re-bleeding. PMID: 30983819 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2019 Category: Gastroenterology Authors: Vitali F, Naegel A, Atreya R, Zopf S, Neufert C, Siebler J, Neurath MF, Rath T Tags: World J Gastroenterol Source Type: research

Performance of tacrolimus in hospitalized patients with steroid-refractory acute severe ulcerative colitis.
CONCLUSION: The short-term outcome of tacrolimus in steroid-refractory acute severe ulcerative colitis was beneficial, and side effects were rare. In all, tacrolimus therapy appears to be a viable option for short-term treatment of steroid-refractory acute severe ulcerative colitis besides ciclosporin and anti-tumor necrosis factor α treatment. PMID: 30983820 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2019 Category: Gastroenterology Authors: Hoffmann P, Wehling C, Krisam J, Pfeiffenberger J, Belling N, Gauss A Tags: World J Gastroenterol Source Type: research

Efficacy and complications of argon plasma coagulation for hemorrhagic chronic radiation proctitis.
CONCLUSION: The long-term efficacy of APC for hemorrhagic CRP is uncertain in patients with telangiectasias present on> 50% of the surface area and ulceration> 1 cm2. PMID: 30983821 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 7, 2019 Category: Gastroenterology Authors: Zhong QH, Liu ZZ, Yuan ZX, Ma TH, Huang XY, Wang HM, Chen DC, Wang JP, Wang L Tags: World J Gastroenterol Source Type: research

Systematic review with meta-analysis on transplantation for alcohol-related liver disease: Very low evidence of improved outcomes.
We report the quality of the evidence according to the GRADE criteria. RESULTS: We analyzed data from 10 studies. Of 1332 participants, 34.2% (456/1332) had undergone liver transplantation, while 65.8% (876/1332) had not. While random effects meta-analysis suggested transplant in comparison to no-transplant had an association of reduced mortality that did not reach statistical significance, relative risk (RR) = 0.51 (0.25-1.05), but not relapse risk, RR = 0.52 (0.18-1.53), significant heterogeneity limited these findings. When restricted to prospective data, transplant compared to no-transplant significantly reduced m...
Source: World Journal of Gastroenterology : WJG - April 7, 2019 Category: Gastroenterology Authors: Shen NT, Londono C, Gold S, Wu A, Mages KC, Brown RSJ Tags: World J Gastroenterol Source Type: research

International consensus statement on robotic hepatectomy surgery in 2018.
Abstract The robotic surgical system has been applied in liver surgery. However, controversies concerns exist regarding a variety of factors including the safety, feasibility, efficacy, and cost-effectiveness of robotic surgery. To promote the development of robotic hepatectomy, this study aimed to evaluate the current status of robotic hepatectomy and provide sixty experts' consensus and recommendations to promote its development. Based on the World Health Organization Handbook for Guideline Development, a Consensus Steering Group and a Consensus Development Group were established to determine the topics, prepare...
Source: World Journal of Gastroenterology : WJG - March 28, 2019 Category: Gastroenterology Authors: Liu R, Wakabayashi G, Kim HJ, Choi GH, Yiengpruksawan A, Fong Y, He J, Boggi U, Troisi RI, Efanov M, Azoulay D, Panaro F, Pessaux P, Wang XY, Zhu JY, Zhang SG, Sun CD, Wu Z, Tao KS, Yang KH, Fan J, Chen XP Tags: World J Gastroenterol Source Type: research

Growing burden of alcoholic liver disease in China: A review.
Abstract Explosive economic growth and increasing social openness in China over the last 30 years have significantly boosted alcohol consumption, and consequently, the incidence of alcoholic liver disease (ALD) in China has increased. Because the epidemiologic and clinical features of ALD in the Chinese population may differ from those of the Caucasian population, this review describes the epidemiology, pathogenesis, genetic polymorphisms, diagnosis, and treatment of ALD in the Chinese population. This updated knowledge of ALD in China provides information needed for a global understanding of ALD and may help in t...
Source: World Journal of Gastroenterology : WJG - March 28, 2019 Category: Gastroenterology Authors: Wang WJ, Xiao P, Xu HQ, Niu JQ, Gao YH Tags: World J Gastroenterol Source Type: research

Esophageal diverticulum: New perspectives in the era of minimally invasive endoscopic treatment.
Abstract Esophageal diverticula are rare conditions that cause esophageal symptoms, such as dysphagia, regurgitation, and chest pain. They are classified according to their location and characteristic pathophysiology into three types: epiphrenic diverticulum, Zenker's diverticulum, and Rokitansky diverticulum. The former two disorders take the form of protrusions, and symptomatic cases require interventional treatment. However, the esophageal anatomy presents distinct challenges to surgical resection of the diverticulum, particularly when it is located closer to the oral orifice. Since the condition itself is not ...
Source: World Journal of Gastroenterology : WJG - March 28, 2019 Category: Gastroenterology Authors: Sato H, Takeuchi M, Hashimoto S, Mizuno KI, Furukawa K, Sato A, Yokoyama J, Terai S Tags: World J Gastroenterol Source Type: research

Anti-tumor necrosis factor α therapy associates to type 17 helper T lymphocytes immunological shift and significant microbial changes in dextran sodium sulphate colitis.
CONCLUSION: Anti-TNFα treatment in experimental model of colitis improves disease activity but it is associated to an increase in Th17 pathway together with gut microbiota alteration. PMID: 30948910 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 28, 2019 Category: Gastroenterology Authors: Petito V, Graziani C, Lopetuso LR, Fossati M, Battaglia A, Arena V, Scannone D, Quaranta G, Quagliariello A, Del Chierico F, Putignani L, Masucci L, Sanguinetti M, Sgambato A, Gasbarrini A, Scaldaferri F Tags: World J Gastroenterol Source Type: research

Gut microbiota profile in healthy Indonesians.
Abstract BACKGROUND: Recently, gut microbiota has been associated with various diseases other than intestinal disease. Thus, there has been rapid growth in the study of gut microbiota. Considering the numerous factors influencing gut microbiota such as age, diet, etc., area-based research is required. Indonesia has numerous different tribes and each of these tribes have different lifestyles. Hence, it is expected that each tribe has a specific gut microbiota. A deeper insight into the composition of gut microbiota can be used to determine the condition of gut microbiota in Indonesians and to consider which treatme...
Source: World Journal of Gastroenterology : WJG - March 28, 2019 Category: Gastroenterology Authors: Rahayu ES, Utami T, Mariyatun M, Hasan PN, Kamil RZ, Setyawan RH, Pamungkaningtyas FH, Harahap IA, Wiryohanjoyo DV, Pramesi PC, Cahyanto MN, Sujaya IN, Juffrie M Tags: World J Gastroenterol Source Type: research

Ursodeoxycholic acid ameliorates hepatic lipid metabolism in LO2 cells by regulating the AKT/mTOR/SREBP-1 signaling pathway.
CONCLUSION: Our findings demonstrate the effect of UDCA in improving NAFLD. UDCA attenuates OA-induced hepatic steatosis mainly by regulation of AKT/mTOR/SREBP-1 signal transduction. PMID: 30948912 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 28, 2019 Category: Gastroenterology Authors: Hu J, Hong W, Yao KN, Zhu XH, Chen ZY, Ye L Tags: World J Gastroenterol Source Type: research

Risk factors for local recurrence and appropriate surveillance interval after endoscopic resection.
Abstract BACKGROUND: Risk factors for local recurrence after polypectomy, endoscopic mucosal resection (EMR), and endoscopic submucosal dissection (ESD) have not been identified. Additionally, the appropriate interval for endoscopic surveillance of colorectal tumors at high-risk of local recurrence has not been established. AIM: To clarify the clinicopathological characteristics of recurrent lesions after endoscopic colorectal tumor resection and determine the appropriate interval. METHODS: Three hundred and sixty patients (1412 colorectal tumors) who underwent polypectomy, EMR, or ESD and received endos...
Source: World Journal of Gastroenterology : WJG - March 28, 2019 Category: Gastroenterology Authors: Komeda Y, Watanabe T, Sakurai T, Kono M, Okamoto K, Nagai T, Takenaka M, Hagiwara S, Matsui S, Nishida N, Tsuji N, Kashida H, Kudo M Tags: World J Gastroenterol Source Type: research

Accuracy of multi-echo Dixon sequence in quantification of hepatic steatosis in Chinese children and adolescents.
Abstract BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is currently the outstanding cause of chronic liver disease in children and adolescents, especially in overweight and obese groups. Liver biopsy is the reference standard to diagnose NAFLD but invasive, thus it is not the best choice in clinical diagnosis and follow-up. Magnetic resonance (MR) is widely used in clinical trials to noninvasively quantify liver fat content in adults and children in foreign countries. While currently, it is rarely used in Chinese children and adolescents. We postulated that quantifying hepatic steatosis by MR could be exten...
Source: World Journal of Gastroenterology : WJG - March 28, 2019 Category: Gastroenterology Authors: Zhao YZ, Gan YG, Zhou JL, Liu JQ, Cao WG, Cheng SM, Bai DM, Wang MZ, Gao FQ, Zhou SM Tags: World J Gastroenterol Source Type: research

Long-term survival of a patient with advanced pancreatic cancer under adjunct treatment with Viscum album extracts: A case report.
CONCLUSION: We present the case of a patient with aPC with R1-resection with development of liver metastasis during the course of treatment who showed an overall survival of 63 mo and a relapse-free survival of 39 mo under increasing VAE therapy. The possible synergistic effect on tumor control of RFA treatment and immune-stimulatory effects of VAE should be further investigated. PMID: 30948915 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 28, 2019 Category: Gastroenterology Authors: Werthmann PG, Kempenich R, Lang-Avérous G, Kienle GS Tags: World J Gastroenterol Source Type: research

Emerging role of 18F-fluorodeoxyglucose positron emission tomography for guiding management of hepatocellular carcinoma.
Abstract Hepatocellular carcinoma (HCC) is one of major causes of cancer mortality worldwide. For decades, 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) has been widely used for staging, predicting prognosis, and detecting cancer recurrence in various types of malignant diseases. Due to low sensitivity of FDG PET for detecting intrahepatic HCC lesions, the clinical value of FDG PET in HCC patients has been limited. However, recent studies with diverse analytic methods have shown that FDG PET has promising role in aiding management of HCC patients. In this review, we will discuss the clinical role...
Source: World Journal of Gastroenterology : WJG - March 21, 2019 Category: Gastroenterology Authors: Lee SM, Kim HS, Lee S, Lee JW Tags: World J Gastroenterol Source Type: research

Noninvasive evaluation of nonalcoholic fatty liver disease: Current evidence and practice.
Abstract With the increasing number of individuals with diabetes and obesity, nonalcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent, affecting one-quarter of adults worldwide. The spectrum of NAFLD ranges from simple steatosis or nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH). NAFLD, especially NASH, may progress to fibrosis, leading to cirrhosis and hepatocellular carcinoma. NAFLD can impose a severe economic burden, and patients with NAFLD-related terminal or deteriorative liver diseases have become one of the main groups receiving liver transplantation. The increasi...
Source: World Journal of Gastroenterology : WJG - March 21, 2019 Category: Gastroenterology Authors: Zhou JH, Cai JJ, She ZG, Li HL Tags: World J Gastroenterol Source Type: research

Economic evaluation of the hepatitis C elimination strategy in Greece in the era of affordable direct-acting antivirals.
CONCLUSION: Without large screening programs, elimination of HCV cannot be achieved. The HCV elimination strategy is feasible and cost-saving despite the uncertainty of the future cost of DAAs in Greece. PMID: 30918426 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2019 Category: Gastroenterology Authors: Gountas I, Sypsa V, Papatheodoridis G, Souliotis K, Athanasakis K, Razavi H, Hatzakis A Tags: World J Gastroenterol Source Type: research

Clinical assessment and identification of immuno-oncology markers concerning the 19-gene based risk classifier in stage IV colorectal cancer.
CONCLUSION: The TCA19 score might be prognostic for target-regimen-specific PFS in stage IV CRC. Down-regulation of SLAMF7 and up-regulation of TREM1 occur in primary and metastatic tumor tissues. PMID: 30918427 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2019 Category: Gastroenterology Authors: Lee JL, Roh SA, Kim CW, Kwon YH, Ha YJ, Kim SK, Kim SY, Cho DH, Kim YS, Kim JC Tags: World J Gastroenterol Source Type: research

Hemodynamic changes in hepatic sinusoids of hepatic steatosis mice.
CONCLUSION: The inner diameter of the hepatic sinusoids decreases along with the decrease in the blood flow velocity within the sinusoids and the changes in the systemic hemorheology. PMID: 30918428 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2019 Category: Gastroenterology Authors: Fan J, Chen CJ, Wang YC, Quan W, Wang JW, Zhang WG Tags: World J Gastroenterol Source Type: research

Diffusion-weighted magnetic resonance imaging and micro-RNA in the diagnosis of hepatic fibrosis in chronic hepatitis C virus.
CONCLUSION: Combining ADC and miRs offers an alternative surrogate non-invasive diagnostic tool for diagnosing and staging hepatic fibrosis in patients with chronic hepatitis C. PMID: 30918429 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 21, 2019 Category: Gastroenterology Authors: Besheer T, Elalfy H, Abd El-Maksoud M, Abd El-Razek A, Taman S, Zalata K, Elkashef W, Zaghloul H, Elshahawy H, Raafat D, Elemshaty W, Elsayed E, El-Gilany AH, El-Bendary M Tags: World J Gastroenterol Source Type: research