Yiguanjian decoction enhances fetal liver stem/progenitor cell-mediated repair of liver cirrhosis through regulation of macrophage activation state.
CONCLUSION: YGJ enhances FLSPC-mediated repair of liver cirrhosis through regulation of macrophage activation state, and YGJ in combination with stem cell transplantation may be a suitable treatment for end-stage liver cirrhosis. PMID: 30479463 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2018 Category: Gastroenterology Authors: Xu Y, Fan WW, Xu W, Jiang SL, Chen GF, Liu C, Chen JM, Zhang H, Liu P, Mu YP Tags: World J Gastroenterol Source Type: research

Ubiquitin-like modifier activating enzyme 2 promotes cell migration and invasion through Wnt/ β-catenin signaling in gastric cancer.
Ubiquitin-like modifier activating enzyme 2 promotes cell migration and invasion through Wnt/β-catenin signaling in gastric cancer. World J Gastroenterol. 2018 Nov 14;24(42):4773-4786 Authors: Li J, Sun X, He P, Liu WQ, Zou YB, Wang Q, Meng XW Abstract AIM: To investigate the function and mechanism of ubiquitin-like modifier activating enzyme 2 (Uba2) in progression of gastric cancer (GC) cells. METHODS: Uba2 level in patients with GC was analyzed by Western blotting and immunohistochemistry. MTT and colony formation assays were performed to examine cell proliferation. Flow cytometry was use...
Source: World Journal of Gastroenterology : WJG - November 14, 2018 Category: Gastroenterology Authors: Li J, Sun X, He P, Liu WQ, Zou YB, Wang Q, Meng XW Tags: World J Gastroenterol Source Type: research

Mode of delivery by an ulcerative colitis mother in a case of twins: Immunological differences in cord blood and placenta.
CONCLUSION: Mode of delivery impacted immune cells profile in cord blood/placenta. In particular frequency of immunosuppressive CD71+ erythroid cells was reduced in C-section delivered newborn. PMID: 30479465 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2018 Category: Gastroenterology Authors: Dunsmore G, Koleva P, Sutton RT, Ambrosio L, Huang V, Elahi S Tags: World J Gastroenterol Source Type: research

Increased end-stage renal disease risk in patients with inflammatory bowel disease: A nationwide population-based study.
Abstract AIM: To estimate the risk of end-stage renal disease (ESRD) in patients with inflammatory bowel disease (IBD). METHODS: From January 2010 to December 2013, patients with Crohn's disease (CD) and ulcerative colitis (UC) were identified, based on both the International Classification of Diseases, 10th revision (ICD-10) and the rare, intractable disease registration program codes from the National Health Insurance (NHI) database in South Korea. We compared 38812 patients with IBD to age- and sex-matched non-IBD controls with a ratio of 1:3. Patients newly diagnosed with ESRD were identified with the ICD...
Source: World Journal of Gastroenterology : WJG - November 14, 2018 Category: Gastroenterology Authors: Park S, Chun J, Han KD, Soh H, Choi K, Kim JH, Lee J, Lee C, Im JP, Kim JS Tags: World J Gastroenterol Source Type: research

Prediction of colorectal tumor grade and invasion depth through narrow-band imaging scoring.
Abstract AIM: To determine the usefulness of assigning narrow-band imaging (NBI) scores for predicting tumor grade and invasion depth in colorectal tumors. METHODS: A total of 161 colorectal lesions were analyzed from 138 patients who underwent endoscopic or surgical resection after conventional colonoscopy and magnifying endoscopy with NBI. The relationships between the surface and vascular patterns of the lesions, as visualized with NBI, and the tumor grade and depth of submucosa (SM) invasion were determined histopathologically. Scores were assigned to distinct features of the surface microstructures of tu...
Source: World Journal of Gastroenterology : WJG - November 14, 2018 Category: Gastroenterology Authors: Maeyama Y, Mitsuyama K, Noda T, Nagata S, Nagata T, Yoshioka S, Yoshida H, Mukasa M, Sumie H, Kawano H, Akiba J, Araki Y, Kakuma T, Tsuruta O, Torimura T Tags: World J Gastroenterol Source Type: research

Burden and outcomes for complex perianal fistulas in Crohn's disease: Systematic review.
CONCLUSION: Complex perianal fistulas in CD pose substantial clinical and humanistic burden. There is a need for effective treatments, especially for patients refractory to anti-tumour necrosis factor-α agents, as evidenced by high failure and relapse rates. PMID: 30479468 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 14, 2018 Category: Gastroenterology Authors: Panes J, Reinisch W, Rupniewska E, Khan S, Forns J, Khalid JM, Bojic D, Patel H Tags: World J Gastroenterol Source Type: research

Chronic hepatitis C, atherosclerosis and cardiovascular disease: What impact of direct-acting antiviral treatments?
Abstract Hepatitis C virus (HCV) infection is associated with extrahepatic manifestations, among these there is an increased risk of atherosclerosis and cardiovascular disease as well as an increased cardiovascular mortality. Several direct and indirect HCV pro-atherogenic mechanisms have been proposed. HCV lives and replicates within carotid plaques, promoting a local environment of pro-atherogenic factors. In addition, it causes conditions such as insulin resistance, diabetes, hepatic steatosis, cryoglobulinemia and endotoxinemia that are associated with the development of atherosclerosis and cardiovascular dise...
Source: World Journal of Gastroenterology : WJG - November 7, 2018 Category: Gastroenterology Authors: Adinolfi LE, Rinaldi L, Nevola R Tags: World J Gastroenterol Source Type: research

Damage-associated molecular patterns in inflammatory bowel disease: From biomarkers to therapeutic targets.
Abstract The chronic inflammatory process underlying inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, derives from the interplay of several components in a genetically susceptible host. These components include environmental elements and gut microbiota a dysbiosis. For decades, immune abnormalities have been investigated as critically important in IBD pathogenesis, and attempts to develop effective therapies have predominantly targeted the immune system. Nevertheless, immune events represent only one of the constituents contributing to IBD pathogenesis within the context of the ...
Source: World Journal of Gastroenterology : WJG - November 7, 2018 Category: Gastroenterology Authors: Nanini HF, Bernardazzi C, Castro F, de Souza HSP Tags: World J Gastroenterol Source Type: research

Concept of histone deacetylases in cancer: Reflections on esophageal carcinogenesis and treatment.
Abstract Esophageal cancer (EC) presents a high mortality rate, mainly due to its aggressive nature. Squamous cell carcinoma is the most common histological type worldwide, though, a continuous increase in esophageal adenocarcinomas has been noted in the past decades. Common risk factors associated with EC include smoking, alcohol consumption, gastroesophageal reflux disease, Barrett's esophagus and obesity. In an effort to overcome chemotherapy resistance in oncology, it was discovered that histone acetylation/deacetylation equilibrium is altered in carcinogenesis, leading to changes in chromatin structure and al...
Source: World Journal of Gastroenterology : WJG - November 7, 2018 Category: Gastroenterology Authors: Schizas D, Mastoraki A, Naar L, Spartalis E, Tsilimigras DI, Karachaliou GS, Bagias G, Moris D Tags: World J Gastroenterol Source Type: research

Role of autophagy in tumorigenesis, metastasis, targeted therapy and drug resistance of hepatocellular carcinoma.
Abstract Autophagy is a "self-degradative" process and is involved in the maintenance of cellular homeostasis and the control of cellular components by facilitating the clearance or turnover of long-lived or misfolded proteins, protein aggregates, and damaged organelles. Autophagy plays a dual role in cancer, including in tumor progression and tumor promotion, suggesting that autophagy acts as a double-edged sword in cancer cells. Liver cancer is one of the greatest leading causes of cancer death worldwide due to its high recurrence rate and poor prognosis. Especially in China, liver cancer has become on...
Source: World Journal of Gastroenterology : WJG - November 7, 2018 Category: Gastroenterology Authors: Huang F, Wang BR, Wang YG Tags: World J Gastroenterol Source Type: research

Mucosal adhesion and anti-inflammatory effects of Lactobacillus rhamnosus GG in the human colonic mucosa: A proof-of-concept study.
Abstract AIM: To investigate the adhesion and anti-inflammatory effects of Lactobacillus rhamnosus GG (LGG) in the colonic mucosa of healthy and ulcerative colitis (UC) patients, both in vivo and ex vivo in an organ culture model. METHODS: For the ex vivo experiment, a total of 98 patients (68 UC patients and 30 normal subjects) were included. Endoscopic biopsies were collected and incubated with and without LGG or LGG-conditioned media to evaluate the mucosal adhesion and anti-inflammatory effects [reduction of tumor necrosis factor alpha (TNFα) and interleukin (IL)-17 expression] of the bacteria, and ...
Source: World Journal of Gastroenterology : WJG - November 7, 2018 Category: Gastroenterology Authors: Pagnini C, Corleto VD, Martorelli M, Lanini C, D'Ambra G, Di Giulio E, Delle Fave G Tags: World J Gastroenterol Source Type: research

Typing of pancreatic cancer-associated fibroblasts identifies different subpopulations.
CONCLUSION: Different immune phenotypic CAF subpopulations can be identified in PC, using markers such as cytoglobin, CD271, and miR-21. Future studies should determine whether CAF subpopulations have different functional properties. PMID: 30416314 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 7, 2018 Category: Gastroenterology Authors: Nielsen MFB, Mortensen MB, Detlefsen S Tags: World J Gastroenterol Source Type: research

Overexpression of G protein-coupled receptor 31 as a poor prognosticator in human colorectal cancer.
We examined GPR31 expression levels in CRC tissues from two independent cohorts via immunohistochemical staining. All patients were categorized into either a GPR31 low expression group or a GPR31 high expression group. The clinicopathological factors and the prognosis of patients in the GPR31 low expression group and GPR31 high expression group were compared. RESULTS: We compared the clinicopathological factors and the prognosis of patients in the GPR31 low expression group and GPR31 high expression group. Significant differences were observed in the number of patients in pM classification between patients in the GPR3...
Source: World Journal of Gastroenterology : WJG - November 7, 2018 Category: Gastroenterology Authors: Rong YM, Huang XM, Fan DJ, Lin XT, Zhang F, Hu JC, Tan YX, Chen X, Zou YF, Lan P Tags: World J Gastroenterol Source Type: research

End-stage renal disease is associated with increased post endoscopic retrograde cholangiopancreatography adverse events in hospitalized patients.
Abstract AIM: To determine if end-stage renal disease (ESRD) is a risk factor for post endoscopic retrograde cholangiopancreatography (ERCP) adverse events (AEs). METHODS: We performed a retrospective cohort study using the Nationwide Inpatient Sample (NIS) 2011-2013. We identified adult patients who underwent ERCP using the International Classification of Diseases 9th Revision (ICD-9-CM). Included patients were divided into three groups: ESRD, chronic kidney disease (CKD), and control. The primary outcome was post-ERCP AEs including pancreatitis, bleeding, and perforation determined based on specific ICD-9-C...
Source: World Journal of Gastroenterology : WJG - November 7, 2018 Category: Gastroenterology Authors: Sawas T, Bazerbachi F, Haffar S, Cho WK, Levy MJ, Martin JA, Petersen BT, Topazian MD, Chandrasekhara V, Abu Dayyeh BK Tags: World J Gastroenterol Source Type: research

Risk of lymph node metastases in patients with T1b oesophageal adenocarcinoma: A retrospective single centre experience.
CONCLUSION: T1b tumours without histopathological high-risk markers of LNM can be treated endoscopically with good out-comes. In selected patients, endoscopic therapy may be appropriate for high-risk lesions. PMID: 30416317 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 7, 2018 Category: Gastroenterology Authors: Graham D, Sever N, Magee C, Waddingham W, Banks M, Sweis R, Al-Yousuf H, Mitchison M, Alzoubaidi D, Rodriguez-Justo M, Lovat L, Novelli M, Jansen M, Haidry R Tags: World J Gastroenterol Source Type: research

Willingness to pay for colorectal cancer screening in Guangzhou.
CONCLUSION: Willingness to pay for colorectal cancer screening in Guangzhou is high, but the amount of willing to pay is not much. PMID: 30416318 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 7, 2018 Category: Gastroenterology Authors: Zhou Q, Li Y, Liu HZ, Liang YR, Lin GZ Tags: World J Gastroenterol Source Type: research

Ductopenia and cirrhosis in a 32-year-old woman with progressive familial intrahepatic cholestasis type 3: A case report and review of the literature.
Abstract Progressive familial intrahepatic cholestasis type 3 is caused by a mutation in the ATP-binding cassette, subfamily B, member 4 (ABCB4) gene encoding multidrug resistance protein 3. A 32-year-old woman with a history of acute hepatitis at age 9 years was found to have jaundice during pregnancy in 2008, and was diagnosed as having intrahepatic cholestasis of pregnancy. In 2009, she underwent cholecystectomy for gallstones and chronic cholecystitis. However, itching and jaundice did not resolve postoperatively. She was admitted to our hospital with fatigue, jaundice, and a recently elevated γ-glutamyl...
Source: World Journal of Gastroenterology : WJG - November 7, 2018 Category: Gastroenterology Authors: Tan YW, Ji HL, Lu ZH, Ge GH, Sun L, Zhou XB, Sheng JH, Gong YH Tags: World J Gastroenterol Source Type: research

Extracellular vesicles in liver disease and beyond.
ro FJ Abstract Extracellular vesicles (EVs) are membrane-derived vesicles which can be released by different cell types, including hepatocytes, hepatic stellate cells and immune cells in normal and pathological conditions. EVs carry lipids, proteins, coding and non-coding RNAs and mitochondrial DNA causing modifications on the recipient cells. These vesicles are considered potential biomarkers and therapeutic agents for human diagnostic and prognostic due to their function as intercellular mediators of cell-cell communication within the liver and between other organs. However, the development and optimization of m...
Source: World Journal of Gastroenterology : WJG - October 28, 2018 Category: Gastroenterology Authors: Morán L, Cubero FJ Tags: World J Gastroenterol Source Type: research

Better surgical treatment method for hepatocellular carcinoma with portal vein tumor thrombus.
In this study, we review the efficacy and principles of current surgical treatments and introduce our new, more effective surgical technique named "thrombectomy first", which means the tumor thrombus in the main portal vein, the bifurcation or the contralateral portal vein should be removed prior to liver resection. Thus, compression and crushing of PVTT during the operation could be avoided and new intrahepatic metastases caused by tumor thrombus to the remnant liver minimized. The new technique is even beneficial to the prognosis of Cheng's classification Types III and IV PVTT. The vital tips and tricks for the...
Source: World Journal of Gastroenterology : WJG - October 28, 2018 Category: Gastroenterology Authors: Peng SY, Wang XA, Huang CY, Li JT, Hong DF, Wang YF, Xu B Tags: World J Gastroenterol Source Type: research

Dimensions of hepatocellular carcinoma phenotypic diversity.
sso O Abstract Hepatocellular carcinoma (HCC) is the 3rd leading cause of cancer-related death worldwide. More than 80% of HCCs arise within chronic liver disease resulting from viral hepatitis, alcohol, hemochromatosis, obesity and metabolic syndrome or genotoxins. Projections based on Western lifestyle and its metabolic consequences anticipate a further increase in incidence, despite recent breakthroughs in the management of viral hepatitis. HCCs display high heterogeneity of molecular phenotypes, which challenges clinical management. However, emerging molecular classifications of HCCs have not yet formed a unif...
Source: World Journal of Gastroenterology : WJG - October 28, 2018 Category: Gastroenterology Authors: Désert R, Nieto N, Musso O Tags: World J Gastroenterol Source Type: research

Second-line rescue treatment of Helicobacter pylori infection: Where are we now?
In conclusion, bismuth quadruple therapy, levofloxacin-amoxicillin triple/quadruple therapy, high-dose dual therapy and TL quadruple therapy can be used as second-line treatment for H. pylori infection. Current evidence suggests that 10-d TL quadruple therapy is a simple and effective regimen, and has the potential to become a universal rescue treatment following eradication failure by all first-line eradication regimens for H. pylori infection. PMID: 30386104 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 28, 2018 Category: Gastroenterology Authors: Lin TF, Hsu PI Tags: World J Gastroenterol Source Type: research

Recovery of natural killer cells is mainly in post-treatment period in chronic hepatitis C patients treated with sofosbuvir plus ledipasvir.
CONCLUSION: NK cells of CHC patients can be affected by DAAs, and phenotypes and function of NK cells recover not at early stage but mainly after the end of sofosbuvir/ledipasvir treatment. PMID: 30386105 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 28, 2018 Category: Gastroenterology Authors: Wang XX, Luo BF, Jiang HJ, Cong X, Jin Q, Ma DL, Wei L, Feng B Tags: World J Gastroenterol Source Type: research

Helicobacter pylori promotes invasion and metastasis of gastric cancer by enhancing heparanase expression.
Abstract AIM: To detect the mechanisms of Helicobacter pylori (H. pylori) infection in the invasion and metastasis of gastric cancer (GC). METHODS: Specimens from 99 patients with GC were collected. The correlation among H. pylori infection, heparanase (HPA) and mitogen-activated protein kinase (MAPK) expression, which was determined by immunohistochemistry, and the clinical features of GC was analysed using SPSS 22.0. Overall survival (OS) and relapse-free survival (RFS) of GC patients were estimated by the Kaplan-Meier method. Independent and multiple factors of HPA and MAPK with prognosis were determined w...
Source: World Journal of Gastroenterology : WJG - October 28, 2018 Category: Gastroenterology Authors: Liu LP, Sheng XP, Shuai TK, Zhao YX, Li B, Li YM Tags: World J Gastroenterol Source Type: research

Self-expandable metal stents in patients with postoperative delayed gastric emptying after distal gastrectomy.
CONCLUSION: Endoscopic stent placement provides prompt relief of obstructive symptoms. Thus, it can be considered an effective and safe salvage technique for post-operative DGE. PMID: 30386107 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 28, 2018 Category: Gastroenterology Authors: Kim SH, Keum B, Choi HS, Kim ES, Seo YS, Jeen YT, Lee HS, Chun HJ, Um SH, Kim CD, Park S Tags: World J Gastroenterol Source Type: research

Second primary malignancy risk after radiotherapy in rectal cancer survivors.
CONCLUSION: In this large population-based cohort study, we demonstrated that radiotherapy had no increase in SPM. PMID: 30386108 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 28, 2018 Category: Gastroenterology Authors: Wang TH, Liu CJ, Chao TF, Chen TJ, Hu YW Tags: World J Gastroenterol Source Type: research

Outcomes of furazolidone- and amoxicillin-based quadruple therapy for Helicobacter pylori infection and predictors of failed eradication.
CONCLUSION: Furazolidone- and amoxicillin-based quadruple therapy for H. pylori infection in an area with a high prevalence of clarithromycin resistance demonstrated high eradication rates as primary and rescue therapies with a favorable safety profile. Patient education targeting abstinence from alcohol during therapy and strict medication adherence may further optimize H. pylori eradication. PMID: 30386109 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 28, 2018 Category: Gastroenterology Authors: Zhang YW, Hu WL, Cai Y, Zheng WF, Du Q, Kim JJ, Kao JY, Dai N, Si JM Tags: World J Gastroenterol Source Type: research

Long term outcome of antiviral therapy in patients with hepatitis B associated decompensated cirrhosis.
CONCLUSION: Long term outcome of decompensated cirrhosis treated with antiviral agent improved much, and incidence of hepatocellular carcinoma and mortality sharply decreased after one year treatment. PMID: 30386110 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 28, 2018 Category: Gastroenterology Authors: Ju YC, Jun DW, Choi J, Saeed WK, Lee HY, Oh HW Tags: World J Gastroenterol Source Type: research

Postoperative survival analysis and prognostic nomogram model for patients with portal hypertension.
CONCLUSION: SSPD achieves or surpasses the long-term survival effect of traditional pericardial devascularisation and is worthy of clinical promotion and application. Nomograms are effective at predicting prognosis. PMID: 30356927 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2018 Category: Gastroenterology Authors: Zhang YF, Ji H, Lu HW, Lu L, Wang L, Wang JL, Li YM Tags: World J Gastroenterol Source Type: research

Fungal dysbiosis predicts the diagnosis of pediatric Crohn's disease.
Abstract AIM: To investigate the accuracy of fungal dysbiosis in mucosa and stool for predicting the diagnosis of Crohn's disease (CD). METHODS: Children were prospectively enrolled in two medical centers: one university hospital and one private gastroenterology clinic in the city of Riyadh, Kingdom of Saudi Arabia. The children with confirmed diagnosis of CD by standard guidelines were considered cases, and the others were considered non-inflammatory bowel disease controls. Mucosal and stool samples were sequenced utilizing Illumina MiSeq chemistry following the manufacturer's protocols, and abundance and di...
Source: World Journal of Gastroenterology : WJG - October 21, 2018 Category: Gastroenterology Authors: El Mouzan MI, Korolev KS, Al Mofarreh MA, Menon R, Winter HS, Al Sarkhy AA, Dowd SE, Al Barrag AM, Assiri AA Tags: World J Gastroenterol Source Type: research

Sheng-jiang powder ameliorates obesity-induced pancreatic inflammatory injury via stimulating activation of the AMPK signalling pathway in rats.
Abstract AIM: To investigate the mechanisms by which Sheng-jiang powder (SJP) ameliorates obesity-induced pancreatic inflammatory injury. METHODS: Sprague-Dawley rats were randomized into three groups: normal group (NG), obese group (HLG), or SJP treatment group (HSG). Obesity was induced by feeding a high-fat diet in the HLG and HSG, while the NG received standard chow. Rats were euthanized after 12 wk, and blood and pancreatic tissues were collected for histopathological analyses. Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and transforming growth factor beta (TGF-β) ex...
Source: World Journal of Gastroenterology : WJG - October 21, 2018 Category: Gastroenterology Authors: Miao YF, Li J, Zhang YM, Zhu L, Chen H, Yuan L, Hu J, Yi XL, Wu QT, Wan MH, Tang WF Tags: World J Gastroenterol Source Type: research

Molecular evaluation of glutathione S transferase family genes in patients with sporadic colorectal cancer.
lo EM Abstract AIM: To evaluate the association between polymorphisms in glutathione S transferases (GSTs) and the risk of sporadic colorectal cancer (SCRC), tumor progression and the survival of patients. METHODS: A case-control study of 970 individuals from the Brazilian population was conducted (232 individuals from the case group with colorectal cancer and 738 individuals from the control group without a history of cancer). PCR multiplex and PCR-RFLP techniques were used to genotype the GST polymorphisms. The tumors were categorized according to the TNM classification: tumor extension (T), affected lymph ...
Source: World Journal of Gastroenterology : WJG - October 21, 2018 Category: Gastroenterology Authors: Rodrigues-Fleming GH, Fernandes GMM, Russo A, Biselli-Chicote PM, Netinho JG, Pavarino ÉC, Goloni-Bertollo EM Tags: World J Gastroenterol Source Type: research

Correction to "Maturity of associating liver partition and portal vein ligation for staged hepatectomy-derived liver regeneration in a rat model [World J Gastroenterol 2018 March 14; 24(10): 1107-1119]".
Correction to "Maturity of associating liver partition and portal vein ligation for staged hepatectomy-derived liver regeneration in a rat model [World J Gastroenterol 2018 March 14; 24(10): 1107-1119]". World J Gastroenterol. 2018 Oct 21;24(39):4517-4518 Authors: Tong YF, Cai XJ Abstract [This corrects the article on p. 1107 in vol. 21, PMID: 26640344.]. PMID: 30356980 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2018 Category: Gastroenterology Authors: Tong YF, Cai XJ Tags: World J Gastroenterol Source Type: research

Barrett's esophagus with high grade dysplasia is associated with non-esophageal cancer.
Abstract AIM: To study factors associated with esophageal and non-esophageal cancer morbidity among Barrett's esophagus (BE) patients. METHODS: A cohort study within a single tertiary center included 386 consecutive patients with biopsy proven BE, who were recruited between 2004-2014. Endoscopic and histologic data were prospectively recorded. Cancer morbidity was obtained from the national cancer registry. Main outcomes were BE related (defined as esophagus and cardia) and non-BE related cancers (all other cancers). Cancer incidence and all-cause mortality were compared between patients with high-grade dyspl...
Source: World Journal of Gastroenterology : WJG - October 21, 2018 Category: Gastroenterology Authors: Bar N, Schwartz N, Nissim M, Fliss-Isacov N, Zelber-Sagi S, Kariv R Tags: World J Gastroenterol Source Type: research

Portal vein thrombosis in cirrhotic patients - it is always the small pieces that make the big picture.
ti C Abstract Portal vein thrombosis (PVT) is a frequent and serious complication in patients with liver cirrhosis (LC). Recently, a new classification of PVT was proposed, although the functional component was not completed included. The status of liver disease (compensated/decompensated) should be added to this classification. Reduced portal flow velocity and the acquired hypercoagulable status associated with LC are the main risk factors for PVT development, although endothelial dysfunction may play an important role that needs to be further evaluated. The European Association for the Study of the Liver and the...
Source: World Journal of Gastroenterology : WJG - October 21, 2018 Category: Gastroenterology Authors: Gîrleanu I, Trifan A, Stanciu C, Sfarti C Tags: World J Gastroenterol Source Type: research

Ursodeoxycholic acid combined with percutaneous transhepatic balloon dilation for management of gallstones after elimination of common bile duct stones.
CONCLUSION: For patients with concomitant CBD stones and gallstones, after percutaneous transhepatic removal of primary CBD stones, oral ursodeoxycholic acid and a high-fat diet followed by percutaneous transhepatic removal of secondary CBD stones appear to be a feasible and effective option for management of gallstones. PMID: 30356997 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 21, 2018 Category: Gastroenterology Authors: Chang HY, Wang CJ, Liu B, Wang YZ, Wang WJ, Wang W, Li D, Li YL Tags: World J Gastroenterol Source Type: research

Agitation thrombolysis combined with catheter-directed thrombolysis for the treatment of non-cirrhotic acute portal vein thrombosis.
Abstract AIM: To evaluate the safety and efficacy of agitation thrombolysis (AT) combined with catheter-directed thrombolysis (CDT) for the treatment of non-cirrhotic acute portal vein thrombosis (PVT). METHODS: Nine patients with non-cirrhotic acute PVT who underwent AT combined with CDT were analyzed retrospectively. Portography was carried out via the transjugular intrahepatic portosystemic (commonly known as TIP) or percutaneous transhepatic (commonly known as PT) route, followed by AT combined with CDT. Complications of the procedure, and the changes in clinical symptoms, hemodynamics of the portal vein ...
Source: World Journal of Gastroenterology : WJG - October 21, 2018 Category: Gastroenterology Authors: Wang CY, Wei LQ, Niu HZ, Gao WQ, Wang T, Chen SJ Tags: World J Gastroenterol Source Type: research

Novel targeting approaches and signaling pathways of colorectal cancer: An insight.
Abstract Colorectal cancer (CRC) is the third most common cancer of mortality in the world. Chemotherapy based treatment leads to innumerable side effects as it delivers the anticancer drug to both normal cells besides cancer cells. Sonic Hedgehog (SHH), Wnt wingless-type mouse mammary tumor virus/β-catenin, transforming growth factor-β/SMAD, epidermal growth factor receptor and Notch are the main signaling pathways involved in the progression of CRC. Targeted therapies necessitate information regarding the particular aberrant pathways. Advancements in gene therapies have resulted in the recognition of n...
Source: World Journal of Gastroenterology : WJG - October 21, 2018 Category: Gastroenterology Authors: Tiwari A, Saraf S, Verma A, Panda PK, Jain SK Tags: World J Gastroenterol Source Type: research

Carcinogenesis on the background of liver fibrosis: Implications for the management of hepatocellular cancer.
Abstract Hepatocellular carcinoma (HCC) is now the second leading cause of cancer-related deaths globally and many patients have incurable disease. HCC predominantly occurs in the setting of liver cirrhosis and is a paradigm for inflammation-induced cancer. The causes of chronic liver disease promote the development of transformed or premalignant hepatocytes and predisposes to the development of HCC. For HCC to grow and progress it is now clear that it requires an immunosuppressive niche within the fibrogenic microenvironment of cirrhosis. The rationale for targeting this immunosuppression is supported by response...
Source: World Journal of Gastroenterology : WJG - October 21, 2018 Category: Gastroenterology Authors: O'Rourke JM, Sagar VM, Shah T, Shetty S Tags: World J Gastroenterol Source Type: research

Circadian rhythms in the pathogenesis of gastrointestinal diseases.
ert M Abstract The etiology of digestive pathologies such as irritable bowel syndrome (IBS), inflammatory bowel diseases (IBD) and cancer is not yet fully understood. In recent years, several studies have evidenced circadian variations in mechanisms involved in digestive health. In situations of disturbed circadian rhythms (chronodisruption) where the central clock and the peripheral clocks receive incoherent signals, the synchronicity is lost producing implications for health. This lack of coordination could alter the tissue function and cause long term damage to the organs. Life habits such as sleep, physical ex...
Source: World Journal of Gastroenterology : WJG - October 14, 2018 Category: Gastroenterology Authors: Codoñer-Franch P, Gombert M Tags: World J Gastroenterol Source Type: research

Challenge to overcome: Nonstructural protein 5A-P32 deletion in direct-acting antiviral-based therapy for hepatitis C virus.
Abstract Interferon (IFN)-based therapy for hepatitis C virus (HCV) infection has recently been replaced by IFN-free direct-acting antiviral (DAA)-based therapy, which has been established as a 1st line therapy with high efficacy and tolerability due to its reasonable safety profile. Resistance-associated substitutions (RASs) have been a weakness of DAA-based therapy. For example, combination therapy with daclatasvir and asunaprevir (DCV/ASV) is less effective for HCV genotype 1-infected patients with Y93H as a nonstructural protein 5A RAS. However, the problem regarding RASs has been gradually overcome with the a...
Source: World Journal of Gastroenterology : WJG - October 14, 2018 Category: Gastroenterology Authors: Sato K, Uraoka T Tags: World J Gastroenterol Source Type: research

Management of bacterial and fungal infections in end stage liver disease and liver transplantation: Current options and future directions.
Abstract Patients with liver cirrhosis are susceptible to infections due to various mechanisms, including abnormalities of humoral and cell-mediated immunity and occurrence of bacterial translocation from the intestine. Bacterial infections are common and represent a reason for progression to liver failure and increased mortality. Fungal infections, mainly caused by Candida spp., are often associated to delayed diagnosis and high mortality rates. High level of suspicion along with prompt diagnosis and treatment of infections are warranted. Bacterial and fungal infections negatively affect the outcomes of liver tra...
Source: World Journal of Gastroenterology : WJG - October 14, 2018 Category: Gastroenterology Authors: Righi E Tags: World J Gastroenterol Source Type: research

Towards hepatitis C virus elimination: Egyptian experience, achievements and limitations.
Abstract Worldwide, more than one million people die each year from hepatitis C virus (HCV) related diseases, and over 300 million people are chronically infected with hepatitis B or C. Egypt used to be on the top of the countries with heavy HCV burden. Some countries are making advances in elimination of HCV, yet multiple factors preventing progress; remain for the majority. These factors include lack of global funding sources for treatment, late diagnosis, poor data, and inadequate screening. Treatment of HCV in Egypt has become one of the top national priorities since 2007. Egypt started a national treatment pr...
Source: World Journal of Gastroenterology : WJG - October 14, 2018 Category: Gastroenterology Authors: Omran D, Alboraie M, Zayed RA, Wifi MN, Naguib M, Eltabbakh M, Abdellah M, Sherief AF, Maklad S, Eldemellawy HH, Saad OK, Khamiss DM, El Kassas M Tags: World J Gastroenterol Source Type: research

Temporal clinical, proteomic, histological and cellular immune responses of dextran sulfate sodium-induced acute colitis.
CONCLUSION: These results demonstrate that the severity of experimental colitis is dependent on DSS concentration, correlated with clinical, proteomic, histological and cellular immune response on 3% DSS. PMID: 30344419 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2018 Category: Gastroenterology Authors: Nunes NS, Kim S, Sundby M, Chandran P, Burks SR, Paz AH, Frank JA Tags: World J Gastroenterol Source Type: research

Analysis of the nitric oxide-cyclic guanosine monophosphate pathway in experimental liver cirrhosis suggests phosphodiesterase-5 as potential target to treat portal hypertension.
CONCLUSION: Overexpression and abrogated zonation of PDE-5 likely contribute to the pathogenesis of cirrhotic portal hypertension. PDE-5 inhibition may therefore be a reasonable therapeutic approach for portal hypertension. PMID: 30344420 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2018 Category: Gastroenterology Authors: Schaffner D, Lazaro A, Deibert P, Hasselblatt P, Stoll P, Fauth L, Baumstark MW, Merfort I, Schmitt-Graeff A, Kreisel W Tags: World J Gastroenterol Source Type: research

Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats.
CONCLUSION: In gastric ulcers, HEEP-induced healing (modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. PMID: 30344421 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2018 Category: Gastroenterology Authors: Périco LL, Rodrigues VP, Ohara R, Bueno G, Nunes VVA, Dos Santos RC, Camargo ACL, Justulin Júnior LA, de Andrade SF, Steimbach VMB, da Silva LM, da Rocha LRM, Vilegas W, Dos Santos C, Hiruma-Lima CA Tags: World J Gastroenterol Source Type: research

Practical fecal calprotectin cut-off value for Japanese patients with ulcerative colitis.
Abstract AIM: To determine appropriate fecal calprotectin cut-off values for the prediction of endoscopic and histologic remission in Japanese patients with ulcerative colitis (UC). METHODS: We performed a cross-sectional observational study of 131 Japanese patients with UC and measured fecal calprotectin levels by fluorescence enzyme immunoassay. The clinical activity of UC was assessed with the partial Mayo score (PMS). Relapse was defined as increase of PMS by 2 points or more in stool frequency or rectal bleeding subscore. The endoscopic and histologic activities of UC were evaluated in 50 patients within...
Source: World Journal of Gastroenterology : WJG - October 14, 2018 Category: Gastroenterology Authors: Urushikubo J, Yanai S, Nakamura S, Kawasaki K, Akasaka R, Sato K, Toya Y, Asakura K, Gonai T, Sugai T, Matsumoto T Tags: World J Gastroenterol Source Type: research

Liver stiffness reversibly increases during pregnancy and independently predicts preeclampsia.
Abstract AIM: To study liver stiffness (LS) during pregnancy and its association with complications during pregnancy. METHODS: In this observational, diagnostic study, 537 pregnant women were prospectively enrolled at the Department of Obstetrics and Gynecology, University hospital Heidelberg and Salem Medical Center. LS was measured using the Fibroscan device (Echosens, Paris) in all women and in 41 cases 24 h after delivery. Clinical and morphological data were recorded and abdominal ultrasound and standard laboratory tests were performed. No complications were observed in 475 women (controls) while preecla...
Source: World Journal of Gastroenterology : WJG - October 14, 2018 Category: Gastroenterology Authors: Ammon FJ, Kohlhaas A, Elshaarawy O, Mueller J, Bruckner T, Sohn C, Fluhr G, Fluhr H, Mueller S Tags: World J Gastroenterol Source Type: research

Hepatitis C virus related cirrhosis decreased as indication to liver transplantation since the introduction of direct-acting antivirals: A single-center study.
CONCLUSION: Introduction of DAAs significantly reduced WL registrations for HCV related cirrhosis, especially in the setting of decompensated cirrhosis. PMID: 30344424 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2018 Category: Gastroenterology Authors: Ferrarese A, Germani G, Gambato M, Russo FP, Senzolo M, Zanetto A, Shalaby S, Cillo U, Zanus G, Angeli P, Burra P Tags: World J Gastroenterol Source Type: research

FANCA D1359Y mutation in a patient with gastric polyposis and cancer susceptibility: A case report and review of literature.
Abstract Gastric polyposis is a rare disease. Not all polyps progress to cancer. Monoallelic mutation in Fanconi anemia (FA) genes, unlike biallelic gene mutations that causes typical FA phenotype, can increase risks of cancers in a sporadic manner. Aberrations in the FA pathway were reported in all molecular subtypes of gastric cancer. We studied a patient with synchronous gastric cancer from gastric polyposis by conducting a 13-year long-term follow up. Via pathway-driven massive parallel genomic sequencing, a germline mutation at FANCA D1359Y was identified. We identified several recurrent mutations in DNA meth...
Source: World Journal of Gastroenterology : WJG - October 14, 2018 Category: Gastroenterology Authors: Huang JP, Lin J, Tzen CY, Huang WY, Tsai CC, Chen CJ, Lu YJ, Chou KF, Su YW Tags: World J Gastroenterol Source Type: research

Focus on the gut-brain axis: Multiple sclerosis, the intestinal barrier and the microbiome.
Abstract The brain-gut axis serves as the bidirectional connection between the gut microbiome, the intestinal barrier and the immune system that might be relevant for the pathophysiology of inflammatory demyelinating diseases. People with multiple sclerosis have been shown to have an altered microbiome, increased intestinal permeability and changes in bile acid metabolism. Experimental evidence suggests that these changes can lead to profound alterations of peripheral and central nervous system immune regulation. Besides being of pathophysiological interest, the brain-gut axis could also open new avenues of therap...
Source: World Journal of Gastroenterology : WJG - October 7, 2018 Category: Gastroenterology Authors: Camara-Lemarroy CR, Metz LM, Yong VW Tags: World J Gastroenterol Source Type: research