Maternal depression and inflammation during pregnancy.
CONCLUSIONS: Depression is associated with a proinflammatory state during pregnancy. These associations are mediated by early pregnancy BMI, and depressive symptoms during pregnancy aggravate the inflammation related to obesity. PMID: 31439060 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - August 23, 2019 Category: Psychiatry Authors: Lahti-Pulkkinen M, Girchenko P, Robinson R, Lehto SM, Toffol E, Heinonen K, Reynolds RM, Kajantie E, Laivuori H, Villa PM, Hämäläinen E, Lahti J, Räikkönen K Tags: Psychol Med Source Type: research

Impulsivity in patients with borderline personality disorder: a comprehensive profile compared with healthy people and patients with ADHD.
CONCLUSIONS: Patients with BPD without ADHD comorbidity had increased self-reported impulsivity and impulsive choice, but intact impulsive action and cognitive functioning. Controlling for ADHD comorbidity in BPD samples is necessary. Negative urgency is the most diagnostically specific impulsivity dimension in BPD. PMID: 31439062 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - August 23, 2019 Category: Psychiatry Authors: Linhartová P, Látalová A, Barteček R, Širůček J, Theiner P, Ejova A, Hlavatá P, Kóša B, Jeřábková B, Bareš M, Kašpárek T Tags: Psychol Med Source Type: research

An update on the efficacy of anti-inflammatory agents for patients with schizophrenia: a meta-analysis.
CONCLUSIONS: Some, but not all agents with anti-inflammatory properties showed efficacy. Effective agents were aspirin, estrogens, minocycline, and NAC. We observed greater beneficial results on symptom severity in FEP or early-phase schizophrenia. PMID: 31439071 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - August 23, 2019 Category: Psychiatry Authors: Çakici N, van Beveren NJM, Judge-Hundal G, Koola MM, Sommer IEC Tags: Psychol Med Source Type: research

Early adulthood psychiatric diagnoses and the subsequent risk of life-time incarceration: a cohort study.
CONCLUSIONS: Results limited the prediction of future incarcerations to persons diagnosed with substance use and antisocial personality, and do not support an independent predictive association between additional psychiatric diagnoses and future incarceration. PMID: 31422774 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - August 19, 2019 Category: Psychiatry Authors: Walsh SD, Dohrenwend BP, Levav I, Weiser M, Gal G Tags: Psychol Med Source Type: research

Anhedonia in chronic pain and prescription opioid misuse.
CONCLUSIONS: Study results suggest that both chronic pain and opioid misuse contribute to anhedonia, which may, in turn, drive further pain and misuse. PMID: 31422776 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - August 19, 2019 Category: Psychiatry Authors: Garland EL, Trøstheim M, Eikemo M, Ernst G, Leknes S Tags: Psychol Med Source Type: research

Childhood trauma and being at-risk for psychosis are associated with higher peripheral endocannabinoids.
Abstract BACKGROUND: Evidence has been accumulating regarding alterations in components of the endocannabinoid system in patients with psychosis. Of all the putative risk factors associated with psychosis, being at clinical high-risk for psychosis (CHR) has the strongest association with the onset of psychosis, and exposure to childhood trauma has been linked to an increased risk of development of psychotic disorder. We aimed to investigate whether being at-risk for psychosis and exposure to childhood trauma were associated with altered endocannabinoid levels. METHOD: We compared 33 CHR participants with 58 h...
Source: Psychological Medicine - August 19, 2019 Category: Psychiatry Authors: Appiah-Kusi E, Wilson R, Colizzi M, Foglia E, Klamerus E, Caldwell A, Bossong MG, McGuire P, Bhattacharyya S Tags: Psychol Med Source Type: research

Equivalency of the diagnostic accuracy of the PHQ-8 and PHQ-9: a systematic review and individual participant data meta-analysis - ERRATUM.
er G, Chagas MH, Chan JCN, Cholera R, Conwell Y, de Manvan Ginkel JM, Fann JR, Fischer FH, Fung D, Gelaye B, Goodyear-Smith F, Greeno CG, Hall BJ, Harrison PA, Härter M, Hegerl U, Hides L, Hobfoll SE, Hudson M, Hyphantis T, Inagaki M, Jetté N, Khamseh ME, Kiely KM, Kwan Y, Lamers F, Liu SI, Lotrakul M, Loureiro SR, Löwe B, McGuire A, Mohd-Sidik S, Munhoz TN, Muramatsu K, Osório FL, Patel V, Pence BW, Persoons P, Picardi A, Reuter K, Rooney AG, Santos IS, Shaaban J, Sidebottom A, Simning A, Stafford L, Sung S, Tan PLL, Turner A, van Weert HC, White J, Whooley MA, Winkley K, Yamada M, Benedetti A, Tho...
Source: Psychological Medicine - August 19, 2019 Category: Psychiatry Authors: Wu Y, Levis B, Riehm KE, Saadat N, Levis AW, Azar M, Rice DB, Boruff J, Cuijpers P, Gilbody S, Ioannidis JPA, Kloda LA, McMillan D, Patten SB, Shrier I, Ziegelstein RC, Akena DH, Arroll B, Ayalon L, Baradaran HR, Baron M, Bombardier CH, Butterworth P, Car Tags: Psychol Med Source Type: research

Social context and the real-world consequences of social anxiety.
CONCLUSIONS: These findings provide a framework for understanding the deleterious consequences of social anxiety in emerging adulthood and set the stage for developing improved intervention strategies. PMID: 31423954 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - August 19, 2019 Category: Psychiatry Authors: Hur J, DeYoung KA, Islam S, Anderson AS, Barstead MG, Shackman AJ Tags: Psychol Med Source Type: research

Using discordant twin methods to investigate an environmentally mediated pathway between social support and the reduced likelihood of adolescent psychotic experiences.
CONCLUSIONS: The protective effects of social support on adolescent psychotic experiences cannot be accounted for by shared environmental or genetic factors, nor by earlier psychopathology. Our findings suggest that early intervention programmes focused on increasing perceptions of social support have the potential to prevent the emergence of psychotic experiences amongst adolescents. PMID: 31414649 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - August 15, 2019 Category: Psychiatry Authors: Crush E, Arseneault L, Danese A, Jaffee SR, Fisher HL Tags: Psychol Med Source Type: research

Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene-environment interaction. The EUGEI study.
CONCLUSIONS: The degree of endophenotypic expression of schizophrenia polygenic risk depends on having a sibling with psychotic disorder, suggestive of underlying gene-environment interaction. Cognitive biases may better index genetic risk of disorder than traditional measures of neurocognition, which instead may reflect the population distribution of cognitive ability impacting the prognosis of psychotic disorder. PMID: 31414981 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - August 15, 2019 Category: Psychiatry Authors: van Os J, Pries LK, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran EŞ, Kaymak SU, Mihaljevic MM, Petrovic SA, Mirjanic T, Bernardo M, Cabre Tags: Psychol Med Source Type: research

The emergence of sex differences in PTSD symptoms across development: evidence from the ALSPAC cohort.
CONCLUSIONS: Results indicate that females show higher levels of PTSS in adolescence but not during childhood. The emergence of this sex difference does not seem to be explained by overlap with depressive symptoms, while the influence of pubertal status requires further investigation. PMID: 31409434 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - August 14, 2019 Category: Psychiatry Authors: Haag K, Fraser A, Hiller R, Seedat S, Zimmerman A, Halligan SL Tags: Psychol Med Source Type: research

Association of a priori dietary patterns with depressive symptoms: a harmonised meta-analysis of observational studies.
CONCLUSION: Population-scale observational evidence indicates that adults following a healthy dietary pattern have fewer depressive symptoms and lower risk of developing depressive symptoms. PMID: 31409435 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - August 14, 2019 Category: Psychiatry Authors: Nicolaou M, Colpo M, Vermeulen E, Elstgeest LEM, Cabout M, Gibson-Smith D, Knuppel A, Sini G, Schoenaker DAJM, Mishra GD, Lok A, Penninx BWJH, Bandinelli S, Brunner EJ, Zwinderman AH, Brouwer IA, Visser M Tags: Psychol Med Source Type: research

Detecting schizophrenia at the level of the individual: relative diagnostic value of whole-brain images, connectome-wide functional connectivity and graph-based metrics.
CONCLUSION: These results were replicated across the three employed ML approaches. Connectome-wide functional connectivity permits differentiation of patients with schizophrenia from healthy controls at single-subject level with greater accuracy; this pattern of results is consistent with the 'dysconnectivity hypothesis' of schizophrenia, which states that the neural basis of the disorder is best understood in terms of system-level functional connectivity alterations. PMID: 31391132 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - August 8, 2019 Category: Psychiatry Authors: Lei D, Pinaya WHL, van Amelsvoort T, Marcelis M, Donohoe G, Mothersill DO, Corvin A, Gill M, Vieira S, Huang X, Lui S, Scarpazza C, Young J, Arango C, Bullmore E, Qiyong G, McGuire P, Mechelli A Tags: Psychol Med Source Type: research

Global deficits in executive functioning are transdiagnostic mediators between severe childhood neglect and psychopathology in adolescence.
CONCLUSIONS: We conclude that stable, global deficits in EF serve as a cognitive endophenotype that increases transdiagnostic vulnerability to psychopathology in adolescence among those who have experienced profound early neglect. PMID: 31391139 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - August 8, 2019 Category: Psychiatry Authors: Wade M, Zeanah CH, Fox NA, Nelson CA Tags: Psychol Med Source Type: research

The relationship between childhood trauma and schizophrenia in the Genomics of Schizophrenia in the Xhosa people (SAX) study in South Africa.
CONCLUSION: Childhood trauma is common in this population. Among many other benefits, interventions to prevent childhood trauma may contribute to a decreasing occurrence of schizophrenia. PMID: 31387660 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - August 7, 2019 Category: Psychiatry Authors: Mall S, Platt JM, Temmingh H, Musenge E, Campbell M, Susser E, Stein DJ Tags: Psychol Med Source Type: research

The dynamic relationship between pain, depression and cognitive function in a sample of newly diagnosed arthritic adults: a cross-lagged panel model.
CONCLUSIONS: The results indicate that better cognitive function might be protective against the emergence of pain prior to an arthritis diagnosis, but cognitive function is subsequently impaired by pain and depression. Furthermore, higher depression predicts lower cognitive function, but not vice versa. This is discussed in the context of the emerging importance of inflammation in depression. PMID: 31387661 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - August 7, 2019 Category: Psychiatry Authors: James RJE, Ferguson E Tags: Psychol Med Source Type: research

Emotional instability as a trait risk factor for eating disorder behaviors in adolescents: Sex differences in a large-scale prospective study.
CONCLUSIONS: Binge eating and purging are common in female and male adolescents. Early temperament/personality factors related to difficulty regulating emotions were predictive of later adolescent eating disorder behaviors. Results have important clinical implications for eating disorder prevention and intervention. PMID: 31379310 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - August 5, 2019 Category: Psychiatry Authors: Brown M, Hochman A, Micali N Tags: Psychol Med Source Type: research

Evidence of shared familial factors influencing neurocognitive endophenotypes in adult- and childhood-onset schizophrenia.
CONCLUSIONS: By comprehensively assessing a wide range of neurocognitive domains in adult- and childhood-onset schizophrenia families, we provide additional support for specific neurocognitive domains as schizophrenia endophenotypes. Whereas comparable estimates of familial transmission for certain dimensions of cognitive functioning support a shared etiology of adult- and childhood-onset neurocognitive function, observed differences may be taken as preliminary evidence of partially divergent multifactorial architectures. PMID: 31362798 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 31, 2019 Category: Psychiatry Authors: Bigdeli TB, Nuechterlein KH, Sugar CA, Subotnik KL, Kubarych T, Neale MC, Kendler KS, Asarnow RF Tags: Psychol Med Source Type: research

Symptom remission at 12-weeks strongly predicts long-term recovery from the first episode of psychosis.
CONCLUSIONS: Symptom remission at 12 weeks is an important predictor of both symptom and functional recovery at 10 years, with implications for illness management. The concepts of clinical and functional recovery overlap but should be considered separately. PMID: 31364523 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 31, 2019 Category: Psychiatry Authors: Dazzan P, Lappin JM, Heslin M, Donoghue K, Lomas B, Reininghaus U, Onyejiaka A, Croudace T, Jones PB, Murray RM, Fearon P, Doody GA, Morgan C Tags: Psychol Med Source Type: research

Interaction of maternal choline levels and prenatal Marijuana's effects on the offspring.
CONCLUSIONS: Prenatal marijuana use adversely affects fetal brain development and subsequent behavioral self-regulation, a precursor to later, more serious problems in childhood. Stopping marijuana use before 10 weeks gestational age prevented these effects. Many mothers refuse to cease use because of familiarity with marijuana and belief in its safety. Higher maternal choline mitigates some of marijuana's adverse effects on the fetus. PMID: 31364525 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 31, 2019 Category: Psychiatry Authors: Hoffman MC, Hunter SK, D'Alessandro A, Noonan K, Wyrwa A, Freedman R Tags: Psychol Med Source Type: research

Multivariate patterns of gray matter volume in thalamic nuclei are associated with positive schizotypy in healthy individuals.
CONCLUSIONS: These findings strengthen the relevance of thalamic structural abnormalities to SCZ and suggest that multivariate thalamic patterns are correlates of the continuum between schizotypy in HC and the full-blown disease. PMID: 31358071 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 30, 2019 Category: Psychiatry Authors: Di Carlo P, Pergola G, Antonucci LA, Bonvino A, Mancini M, Quarto T, Rampino A, Popolizio T, Bertolino A, Blasi G Tags: Psychol Med Source Type: research

Design choices when estimating the treated incidence of schizophrenia.
PMID: 31347479 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 26, 2019 Category: Psychiatry Authors: Hogerzeil SJ, van Hemert AM Tags: Psychol Med Source Type: research

Four reasons why early detection centers for psychosis should be renamed and their treatment targets reconsidered: we should not catastrophize a future we can neither reliably predict nor change.
Abstract Since the 1990s, facilities for individuals at putative risk for psychosis have mushroomed and within a very short time have become part of the standard psychiatric infrastructure in many countries. The idea of preventing a severe mental disorder before its exacerbation is laudable, and early data indeed strongly suggested that the sooner the intervention, the better the outcome. In this paper, the authors provide four reasons why they think that early detection or prodromal facilities should be renamed and their treatment targets reconsidered. First, the association between the duration of untreated psyc...
Source: Psychological Medicine - July 24, 2019 Category: Psychiatry Authors: Moritz S, Gawęda Ł, Heinz A, Gallinat J Tags: Psychol Med Source Type: research

New/emerging psychoactive substances and associated psychopathological consequences.
CONCLUSIONS: The ever-increasing changes in terms of recreational psychotropics' availability represent a relatively new challenge for psychiatry, as the pharmacodynamics and pharmacokinetics of many NPS have not been thoroughly understood. Health/mental health professionals should be informed about the range of NPS; their intake modalities; their psychoactive sought-after effects; the idiosyncratic psychotropics' combinations and finally, their medical and psychopathological risks. PMID: 31327332 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 22, 2019 Category: Psychiatry Authors: Schifano F, Napoletano F, Chiappini S, Guirguis A, Corkery JM, Bonaccorso S, Ricciardi A, Scherbaum N, Vento A Tags: Psychol Med Source Type: research

Vitamin D concentration and psychotic disorder: associations with disease status, clinical variables and urbanicity.
CONCLUSIONS: Lower vitamin D levels in patients with psychotic disorder may in part reflect the effect of psychosis risk mediated by early environmental adversity. The data also suggest that lower vitamin D and psychopathology may be related through direct or indirect mechanisms. PMID: 31327333 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 22, 2019 Category: Psychiatry Authors: van der Leeuw C, de Witte LD, Stellinga A, van der Ley C, Bruggeman R, Kahn RS, van Os J, Marcelis M, for G.R.O.U.P. Tags: Psychol Med Source Type: research

Impaired cognitive self-awareness mediates the association between alexithymia and excitation/inhibition balance in the pgACC.
CONCLUSION: Our results corroborate the importance of the pgACC as a mediating region of alexithymia, reflected in an altered E/I balance. Furthermore, we could specify that this altered balance is linked to a GABA-related modulation of cognitive self-awareness of emotions. PMID: 31328716 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 22, 2019 Category: Psychiatry Authors: Kühnel A, Widmann A, Colic L, Herrmann L, Demenescu LR, Leutritz AL, Li M, Grimm S, Nolte T, Fonagy P, Walter M Tags: Psychol Med Source Type: research

Synaptic and brain-expressed gene sets relate to the shared genetic risk across five psychiatric disorders.
CONCLUSIONS: We obtained novel evidence for shared biological mechanisms that act across psychiatric disorders and we showed that several gene sets that have been related to individual disorders play a role in a broader range of psychiatric disorders. PMID: 31328717 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 22, 2019 Category: Psychiatry Authors: Hammerschlag AR, de Leeuw CA, Middeldorp CM, Polderman TJC Tags: Psychol Med Source Type: research

Comorbidity of substance misuse with anxiety-related and depressive disorders: a genetically informative population study of 3 million individuals in Sweden.
CONCLUSIONS: Substance misuse and anxiety/depression are associated at the population level, and these associations are partially explained by familial liabilities. Our findings indicate a common genetic etiology but are also compatible with a potential partially causal relationship between substance misuse and anxiety/depression. PMID: 31328718 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 22, 2019 Category: Psychiatry Authors: Virtanen S, Kuja-Halkola R, Mataix-Cols D, Jayaram-Lindström N, D'Onofrio BM, Larsson H, Rück C, Suvisaari J, Lichtenstein P, Latvala A Tags: Psychol Med Source Type: research

Meditation techniques v. relaxation therapies when treating anxiety: a meta-analytic review.
ers P Abstract To what extent meditation techniques (which incorporate practices to regulate attention, construct individual values, or deconstruct self-related assumptions), are more or less effective than relaxation therapy in the treatment of anxiety, is not clear. The aim of this study was to examine the effectiveness of meditation compared to relaxation in reducing anxiety. A systematic review from PubMed, Embase, PsycInfo and the Cochrane Central was conducted. A meta-analysis of 14 RCTs (n = 862 participants suffering from anxiety disorders or high trait anxiety) was performed. Effect sizes (ESs) were deter...
Source: Psychological Medicine - July 19, 2019 Category: Psychiatry Authors: Montero-Marin J, Garcia-Campayo J, Pérez-Yus MC, Zabaleta-Del-Olmo E, Cuijpers P Tags: Psychol Med Source Type: research

Familial factors and the risk of borderline personality pathology: genetic and environmental transmission.
CONCLUSIONS: Parental externalizing psychopathology and father's BPD traits contribute genetic risk for offspring BPD traits, but mothers' BPD traits and parents' poor parenting constitute environmental risks for the development of these offspring traits. PMID: 31317840 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 18, 2019 Category: Psychiatry Authors: Fatimah H, Wiernik BM, Gorey C, McGue M, Iacono WG, Bornovalova MA Tags: Psychol Med Source Type: research

Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures.
CONCLUSIONS: Our significant results indicate that MDD case-control differences in RACC thickness vary as a function of SCZ PRS. Although this was not the case for most other brain measures assessed, our specific findings still provide some further evidence that MDD in the presence of high genetic risk for SCZ is subtly neurobiologically distinct from MDD in general. PMID: 31317844 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 18, 2019 Category: Psychiatry Authors: Harris MA, Shen X, Cox SR, Gibson J, Adams MJ, Clarke TK, Deary IJ, Lawrie SM, McIntosh AM, Whalley HC Tags: Psychol Med Source Type: research

Who will benefit from computerized cognitive remediation therapy? Evidence from a multisite randomized controlled study in schizophrenia.
CONCLUSIONS: CCRT can improve the cognitive function of patients with schizophrenia. Changes in cognitive outcomes also contributed to improvements in functional outcomes either directly or solely in the context of CCRT. Age and the basic cognitive level of the participants seem to affect the cognitive benefits from CCRT. PMID: 31298171 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 12, 2019 Category: Psychiatry Authors: Tan S, Zhu X, Fan H, Tan Y, Yang F, Wang Z, Zhao Y, Fan F, Guo J, Li Z, Quan W, Wang X, Reeder C, Zhou D, Zou Y, Wykes T Tags: Psychol Med Source Type: research

Self-harm in women with postpartum mental disorders.
CONCLUSIONS: Women with PPMD had a high risk of self-harm, although lower than risks observed in other psychiatric patients. However, PPMD women who had self-harmed constituted a vulnerable group at significantly increased risk of later suicide. PMID: 31298172 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 12, 2019 Category: Psychiatry Authors: Johannsen BM, Larsen JT, Laursen TM, Ayre K, Howard LM, Meltzer-Brody S, Bech BH, Munk-Olsen T Tags: Psychol Med Source Type: research

Investigating patterns of neural response associated with childhood abuse v. childhood neglect - Corrigendum.
PMID: 31298173 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 12, 2019 Category: Psychiatry Authors: Puetz VB, Viding E, Gerin MI, Pingault JB, Sethi A, Knodt AR, Radtke SR, Brigidi BD, Hariri AR, McCrory E Tags: Psychol Med Source Type: research

Transdiagnostic validity of the MATRICS Consensus Cognitive Battery across the autism-schizophrenia spectrum.
CONCLUSIONS: To our knowledge, this study is the first to establish the validity of a standard cognitive battery in adults with ASD and furthermore the first to establish a cognitive battery's comparability across ASD and schizophrenia. Cognitive domain scores can be compared across new samples using weighted sums of MCCB scores resulting from this study. These findings highlight MCCB's applicability to ASD and support its utility for standardizing treatment evaluation of cognitive outcomes across the autism-schizophrenia spectrum. PMID: 31298174 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 12, 2019 Category: Psychiatry Authors: Kuo SS, Wojtalik JA, Mesholam-Gately RI, Keshavan MS, Eack SM Tags: Psychol Med Source Type: research

Equivalency of the diagnostic accuracy of the PHQ-8 and PHQ-9: a systematic review and individual participant data meta-analysis.
CONCLUSIONS: PHQ-8 and PHQ-9 total scores were similar. Sensitivity may be minimally reduced with the PHQ-8, but specificity is similar. PMID: 31298180 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 12, 2019 Category: Psychiatry Authors: Wu Y, Levis B, Riehm KE, Saadat N, Levis AW, Azar M, Rice DB, Boruff J, Cuijpers P, Gilbody S, Ioannidis JPA, Kloda LA, McMillan D, Patten SB, Shrier I, Ziegelstein RC, Akena DH, Arroll B, Ayalon L, Baradaran HR, Baron M, Bombardier CH, Butterworth P, Car Tags: Psychol Med Source Type: research

Demographic, psychological, behavioral, and cognitive correlates of BMI in youth: Findings from the Adolescent Brain Cognitive Development (ABCD) study.
CONCLUSIONS: Beyond demographics and stimulant use, this study highlights abstract reasoning as an important cognitive variable and reaffirms social problems and screen time as significant correlates of BMI and as modifiable therapeutic targets. Prospective data are needed to understand the predictive power of these variables for BMI gain. PMID: 31288867 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 10, 2019 Category: Psychiatry Authors: Gray JC, Schvey NA, Tanofsky-Kraff M Tags: Psychol Med Source Type: research

Long-term disability in major depressive disorder: a 6-year follow-up study.
CONCLUSIONS: Symptomatic remission is a prerequisite for improvements in disability. However, disability persists despite symptom remission. Therefore, treatment of MDD should include an explicit focus on disability, especially on the more complex domains. To this end, treatments should promote behavioural activation and address subthreshold depressive symptoms in patients with remitted MDD. PMID: 31284881 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 9, 2019 Category: Psychiatry Authors: Iancu SC, Wong YM, Rhebergen D, van Balkom AJLM, Batelaan NM Tags: Psychol Med Source Type: research

Peripheral inflammatory and neurotrophic biomarkers of cognitive impairment in schizophrenia: a meta-analysis.
CONCLUSIONS: Current findings suggest that cognitive impairment in schizophrenia is significantly related to elevated CRP and reduced BDNF levels in schizophrenia, particularly in chronic samples. However, small effect sizes of these correlations suggest that inflammation and decreased BDNF levels do not play a major role in cognitive dysfunction in most patients with schizophrenia. Further studies are needed to investigate the potential intermediating and confounding factors which can influence the level of relationship between inflammation, neurotrophic factors and cognition in schizophrenia. PMID: 31284882 [PubMed ...
Source: Psychological Medicine - July 9, 2019 Category: Psychiatry Authors: Bora E Tags: Psychol Med Source Type: research

Examining belief and confidence in schizophrenia - ADDENDUM.
PMID: 31280731 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 8, 2019 Category: Psychiatry Authors: Joyce DW, Averbeck BB, Frith CD, Shergill SS Tags: Psychol Med Source Type: research

Associations between negative life experiences and the mental health of trans and gender diverse young people in Australia: findings from Trans Pathways.
CONCLUSIONS: The current results highlight the urgent need for better mental health care and provide insight into areas for targeted mental health interventions. These findings are pertinent for clinicians working with trans young people and wider society. PMID: 31280740 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 8, 2019 Category: Psychiatry Authors: Strauss P, Cook A, Winter S, Watson V, Wright Toussaint D, Lin A Tags: Psychol Med Source Type: research

Dissecting the impact of depression on decision-making.
CONCLUSIONS: Depressed adults responded slower than controls in both studies, and poorer performance led the MDD group to receive fewer rewards than controls in Study 1. These results did not reflect a sensorimotor deficit but were instead due to sluggish evidence accumulation. Thus, slowed decision-making-not slowed perception or response execution-caused the performance deficit in MDD. If these results generalize to other tasks, they may help explain the broad cognitive deficits seen in depression. PMID: 31280757 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 8, 2019 Category: Psychiatry Authors: Lawlor VM, Webb CA, Wiecki TV, Frank MJ, Trivedi M, Pizzagalli DA, Dillon DG Tags: Psychol Med Source Type: research

Impairment in the goal-directed corticostriatal learning system as a biomarker for obsessive-compulsive disorder.
CONCLUSIONS: The same changes in EC were present in both OCD patients and their unaffected first-degree relatives suggest that impairment in the goal-directed learning system may be a biomarker for OCD. PMID: 31272523 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 5, 2019 Category: Psychiatry Authors: Dong C, Yang Q, Liang J, Seger CA, Han H, Ning Y, Chen Q, Peng Z Tags: Psychol Med Source Type: research

Cognitive reserve attenuates age-related cognitive decline in the context of putatively accelerated brain ageing in schizophrenia-spectrum disorders.
CONCLUSIONS: In schizophrenia-spectrum illness, CR may negate ageing effects on fluid reasoning by buffering against pathologically exaggerated structural brain deterioration through some form of compensation. CR may represent an important modifier that could explain inconsistencies in brain structure - cognition outcomes in the extant literature. PMID: 31274065 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 5, 2019 Category: Psychiatry Authors: Van Rheenen TE, Cropley V, Fagerlund B, Wannan C, Bruggemann J, Lenroot RK, Sundram S, Weickert CS, Weickert TW, Zalesky A, Bousman CA, Pantelis C Tags: Psychol Med Source Type: research

Stressful life events moderate the effect of neural reward responsiveness in childhood on depressive symptoms in adolescence.
CONCLUSIONS: These results suggest that the RewP reflects a vulnerability for depression that is activated by stress. PMID: 31274066 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 5, 2019 Category: Psychiatry Authors: Goldstein BL, Kessel EM, Kujawa A, Finsaas MC, Davila J, Hajcak G, Klein DN Tags: Psychol Med Source Type: research

Neural signatures of conditioning, extinction learning, and extinction recall in posttraumatic stress disorder: a meta-analysis of functional magnetic resonance imaging studies.
CONCLUSION: Findings from this metanalysis suggest that PTSD is characterized by increased activation in areas related to salience and threat, and lower activation in the thalamus, a key relay hub between subcortical areas. If replicated, these fear network alterations may serve as objective diagnostic markers for PTSD, and potential targets for novel treatment development, including pharmacological and brain stimulation interventions. Future longitudinal studies are needed to examine whether these observed network alteration in PTSD are the cause or the consequence of PTSD. PMID: 31258096 [PubMed - as supplied by pub...
Source: Psychological Medicine - July 1, 2019 Category: Psychiatry Authors: Suarez-Jimenez B, Albajes-Eizagirre A, Lazarov A, Zhu X, Harrison BJ, Radua J, Neria Y, Fullana MA Tags: Psychol Med Source Type: research

Do neighborhood social processes moderate the etiology of youth conduct problems?
CONCLUSIONS: The neighborhood social processes evaluated here do not appear to exert their effects on child CP via etiologic moderation. The documented links between neighborhood social processes and child CP are thus likely to reflect a different etiologic process. Possibilities include environmental main effects of neighborhood social processes on child CP, or genotype-environment correlations. PMID: 31258102 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 1, 2019 Category: Psychiatry Authors: Burt SA, Clark DA, Pearson AL, Klump KL, Neiderhiser JM Tags: Psychol Med Source Type: research

Internalizing and externalizing psychopathology in middle age: genetic and environmental architecture and stability of symptoms over 15 to 20 years.
CONCLUSIONS: These findings demonstrate the considerable stability of internalizing and externalizing psychopathology symptoms across middle age, especially their genetic influences. Diagnostic interviews effectively predict self-reported symptoms and behaviors 15-20 years later. PMID: 31258104 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 1, 2019 Category: Psychiatry Authors: Gustavson DE, Franz CE, Panizzon MS, Lyons MJ, Kremen WS Tags: Psychol Med Source Type: research

Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels.
CONCLUSIONS: About a quarter of patients with depression show evidence of low-grade inflammation, and over half of patients show mildly elevated CRP levels. There are significant differences in the prevalence of low-grade inflammation between patients and matched healthy controls. These findings suggest that inflammation could be relevant to a large number of patients with depression. PMID: 31258105 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 1, 2019 Category: Psychiatry Authors: Osimo EF, Baxter LJ, Lewis G, Jones PB, Khandaker GM Tags: Psychol Med Source Type: research

Association of PTSD symptom groups with functional impairment and distress in trauma-exposed disaster survivors.
CONCLUSIONS: In this and other studies, group C and numbing specifically have been shown to be associated with criterion F, which is consistent with the demonstration that group C and the numbing component specifically are central to the psychopathology of PTSD. The addition of the distress/impairment requirement broadly across the psychiatric diagnoses in DSM-IV added little value to PTSD symptom criteria. Future revisions of diagnostic criteria may benefit by carefully considering these findings to possibly re-include a prominent numbing symptom section. PMID: 31258106 [PubMed - as supplied by publisher] (Source: Ps...
Source: Psychological Medicine - July 1, 2019 Category: Psychiatry Authors: North CS, Van Enkevort E, Hong BA, Surís AM Tags: Psychol Med Source Type: research