Changes in peripheral blood compounds following psychopharmacological treatment in drug-na ïve first-episode patients with either schizophrenia or major depressive disorder: a meta-analysis
Psychol Med. 2021 Mar 3:1-12. doi: 10.1017/S0033291721000155. Online ahead of print.ABSTRACTBACKGROUND: This meta-analysis on peripheral blood compounds in drug-naïve first-episode patients with either schizophrenia or major depressive disorder (MDD) examined which compounds change following psychopharmacological treatment.METHODS: The Embase, PubMed and PsycINFO databases were systematically searched for longitudinal studies reporting measurements of blood compounds in drug-naïve first-episode schizophrenia or MDD.RESULTS: For this random-effects meta-analysis, we retrieved a total of 31 studies comprising 1818 ...
Source: Psychological Medicine - March 3, 2021 Category: Psychiatry Authors: Nuray Çakici Arjen L Sutterland Brenda W J H Penninx Lieuwe de Haan Nico J M van Beveren Source Type: research

Mediators of the longitudinal relationship between childhood adversity and late adolescent psychopathology
CONCLUSIONS: Parent-child conflict explains more than a third of the relationship between CA and later psychopathology. Self-concept and physical activity explain the additional proportion of the relationship between CA and internalizing problems. This suggests that these factors may be good targets for intervention in young people who have experienced CA to prevent subsequent psychopathology.PMID:33653424 | DOI:10.1017/S0033291721000477 (Source: Psychological Medicine)
Source: Psychological Medicine - March 3, 2021 Category: Psychiatry Authors: Colm Healy Aisling Eaton Isabel Cotter Ellen Carter Niamh Dhondt Mary Cannon Source Type: research

Understanding different trajectories of mental health across the general population during the COVID-19 pandemic
Psychol Med. 2021 Mar 3:1-17. doi: 10.1017/S0033291721000957. Online ahead of print.NO ABSTRACTPMID:33653426 | DOI:10.1017/S0033291721000957 (Source: Psychological Medicine)
Source: Psychological Medicine - March 3, 2021 Category: Psychiatry Authors: Rob Saunders Joshua E J Buckman Peter Fonagy Daisy Fancourt Source Type: research

Depression and worry symptoms predict future executive functioning impairment via inflammation
CONCLUSIONS: Inflammation can function as a mechanism of the T1 MDD or GAD-T3 EF associations. Interventions that successfully treat depression, anxiety, and inflammation-linked disorders may avert EF decrements.PMID:33653430 | DOI:10.1017/S0033291721000398 (Source: Psychological Medicine)
Source: Psychological Medicine - March 3, 2021 Category: Psychiatry Authors: Nur Hani Zainal Michelle G Newman Source Type: research

Association between complement component 4A expression, cognitive performance and brain imaging measures in UK Biobank
CONCLUSIONS: These results demonstrate that the C4 risk locus is associated with the central endophenotypes of cognitive performance and brain morphology, even when considered independently of other genetic risk factors and in individuals without mental or neurological disorders.PMID:33653435 | DOI:10.1017/S0033291721000179 (Source: Psychological Medicine)
Source: Psychological Medicine - March 3, 2021 Category: Psychiatry Authors: Kevin S O'Connell Ida E S ønderby Oleksandr Frei Dennis van der Meer Lavinia Athanasiu Olav B Smeland Dag Aln æs Tobias Kaufmann Lars T Westlye Vidar M Steen Ole A Andreassen Timothy Hughes Srdjan Djurovic Source Type: research

Adolescent social networks matter for suicidal trajectories: disparities across race/ethnicity, sex, sexual identity, and socioeconomic status
CONCLUSIONS: Social networks during adolescence influenced the odds of belonging to distinct suicidal trajectories. Family cohesion protected youth from being in high-risk developmental courses of suicidal behaviors. Social networks, especially quality of interactions, may improve detecting adolescents and young adults at-risk for suicide behaviors. Network-based interventions are key to prevent suicidal behaviors over time and suicide intervention programming.PMID:33653436 | DOI:10.1017/S0033291721000465 (Source: Psychological Medicine)
Source: Psychological Medicine - March 3, 2021 Category: Psychiatry Authors: Yunyu Xiao Michael A Lindsey Source Type: research

Investigating the effect of national government physical distancing measures on depression and anxiety during the COVID-19 pandemic through meta-analysis and meta-regression
Psychol Med. 2021 Mar 2:1-46. doi: 10.1017/S0033291721000933. Online ahead of print.NO ABSTRACTPMID:33648613 | DOI:10.1017/S0033291721000933 (Source: Psychological Medicine)
Source: Psychological Medicine - March 2, 2021 Category: Psychiatry Authors: Jo ão M Castaldelli-Maia Megan E Marziali Ziyin Lu Silvia S Martins Source Type: research

Apolipoprotein E e4 allele status and later-life depression in the Lothian Birth Cohort 1936
CONCLUSIONS: There was no evidence that APOE e4 carriers experience an increased risk for later-life depression.PMID:33648619 | DOI:10.1017/S0033291721000623 (Source: Psychological Medicine)
Source: Psychological Medicine - March 2, 2021 Category: Psychiatry Authors: Matthew H Iveson Adele Taylor Sarah E Harris Ian J Deary Andrew M McIntosh Source Type: research

Anxiety and depression during the first wave of COVID-19 in Germany - results of repeated cross-sectional surveys
Psychol Med. 2021 Mar 2:1-10. doi: 10.1017/S0033291721000866. Online ahead of print.NO ABSTRACTPMID:33648621 | DOI:10.1017/S0033291721000866 (Source: Psychological Medicine)
Source: Psychological Medicine - March 2, 2021 Category: Psychiatry Authors: A-K Br äscher C Benke B M Weism üller E Asselmann E-M Skoda M A Teufel S M Jungmann M Witth öft C A Pan é-Farré Source Type: research

Perceived major experiences of discrimination, ethnic group, and risk of psychosis in a six-country case-control study
CONCLUSIONS: Pervasive experiences of discrimination are associated with slightly increased odds of psychotic disorders and may minimally help explain excess risk for minority ethnic groups.PMID:33648622 | DOI:10.1017/S0033291721000453 (Source: Psychological Medicine)
Source: Psychological Medicine - March 2, 2021 Category: Psychiatry Authors: Supriya Misra Bizu Gelaye David R Williams Karestan C Koenen Christina P C Borba Diego Quattrone Marta Di Forti Giada Tripoli Caterina La Cascia Daniele La Barbera Laura Ferraro Ilaria Tarricone Domenico Berardi Antonio Lasalvia Sarah Tosato Andrei Sz ök Source Type: research

Investigating the effect of national government physical distancing measures on depression and anxiety during the COVID-19 pandemic through meta-analysis and meta-regression
Psychol Med. 2021 Mar 2:1-46. doi: 10.1017/S0033291721000933. Online ahead of print.NO ABSTRACTPMID:33648613 | DOI:10.1017/S0033291721000933 (Source: Psychological Medicine)
Source: Psychological Medicine - March 2, 2021 Category: Psychiatry Authors: Jo ão M Castaldelli-Maia Megan E Marziali Ziyin Lu Silvia S Martins Source Type: research

Apolipoprotein E e4 allele status and later-life depression in the Lothian Birth Cohort 1936
CONCLUSIONS: There was no evidence that APOE e4 carriers experience an increased risk for later-life depression.PMID:33648619 | DOI:10.1017/S0033291721000623 (Source: Psychological Medicine)
Source: Psychological Medicine - March 2, 2021 Category: Psychiatry Authors: Matthew H Iveson Adele Taylor Sarah E Harris Ian J Deary Andrew M McIntosh Source Type: research

Anxiety and depression during the first wave of COVID-19 in Germany - results of repeated cross-sectional surveys
Psychol Med. 2021 Mar 2:1-10. doi: 10.1017/S0033291721000866. Online ahead of print.NO ABSTRACTPMID:33648621 | DOI:10.1017/S0033291721000866 (Source: Psychological Medicine)
Source: Psychological Medicine - March 2, 2021 Category: Psychiatry Authors: A-K Br äscher C Benke B M Weism üller E Asselmann E-M Skoda M A Teufel S M Jungmann M Witth öft C A Pan é-Farré Source Type: research

Perceived major experiences of discrimination, ethnic group, and risk of psychosis in a six-country case-control study
CONCLUSIONS: Pervasive experiences of discrimination are associated with slightly increased odds of psychotic disorders and may minimally help explain excess risk for minority ethnic groups.PMID:33648622 | DOI:10.1017/S0033291721000453 (Source: Psychological Medicine)
Source: Psychological Medicine - March 2, 2021 Category: Psychiatry Authors: Supriya Misra Bizu Gelaye David R Williams Karestan C Koenen Christina P C Borba Diego Quattrone Marta Di Forti Giada Tripoli Caterina La Cascia Daniele La Barbera Laura Ferraro Ilaria Tarricone Domenico Berardi Antonio Lasalvia Sarah Tosato Andrei Sz ök Source Type: research

Relationships between attention to emotion and anxiety among a community sample of adolescents
CONCLUSIONS: This is the largest study to date examining eye-tracking metrics of attention to threat among healthy and anxious youth. Findings did not support the notion that anxiety is characterized by heightened vigilance or avoidance/maintenance of attention to threat. All effects detected were extremely small. Links between attention to threat and anxiety among adolescents may be subtle and highly dependent on experimental task dimensions.PMID:33641686 | DOI:10.1017/S0033291720003360 (Source: Psychological Medicine)
Source: Psychological Medicine - March 1, 2021 Category: Psychiatry Authors: Benjamin C Mullin Jacob B W Holzman Laura Pyle Emmaly L Perks Yaswanth Chintaluru Lauren D Gulley Dustin A Haraden Benjamin L Hankin Source Type: research

Relationships between attention to emotion and anxiety among a community sample of adolescents
CONCLUSIONS: This is the largest study to date examining eye-tracking metrics of attention to threat among healthy and anxious youth. Findings did not support the notion that anxiety is characterized by heightened vigilance or avoidance/maintenance of attention to threat. All effects detected were extremely small. Links between attention to threat and anxiety among adolescents may be subtle and highly dependent on experimental task dimensions.PMID:33641686 | DOI:10.1017/S0033291720003360 (Source: Psychological Medicine)
Source: Psychological Medicine - March 1, 2021 Category: Psychiatry Authors: Benjamin C Mullin Jacob B W Holzman Laura Pyle Emmaly L Perks Yaswanth Chintaluru Lauren D Gulley Dustin A Haraden Benjamin L Hankin Source Type: research

Investigating Data-driven Biological Subtypes of Psychiatric Disorders Using Specification-Curve Analysis - ERRATUM
Psychol Med. 2021 Feb 26:1. doi: 10.1017/S0033291721000660. Online ahead of print.NO ABSTRACTPMID:33632352 | DOI:10.1017/S0033291721000660 (Source: Psychological Medicine)
Source: Psychological Medicine - February 26, 2021 Category: Psychiatry Authors: Lian Beijers Hanna M van Loo Jan-Willem Romeijn Femke Lamers Robert A Schoevers Klaas J Wardenaar Source Type: research

Predicting suicidal ideation in a nationally representative sample of young adults: a 12-month prospective study
CONCLUSIONS: The current findings highlight the importance of targeting perceived burdensomeness and internal entrapment to reduce the likelihood that suicidal ideation emerges in at risk individuals.PMID:33634764 | DOI:10.1017/S0033291720005255 (Source: Psychological Medicine)
Source: Psychological Medicine - February 26, 2021 Category: Psychiatry Authors: Karen Wetherall Seonaid Cleare Sarah Eschle Eamonn Ferguson Daryl B O'Connor Ronan E O'Carroll Rory C O'Connor Source Type: research

Associations between insomnia and reward learning in clinical depression
CONCLUSIONS: Among individuals with depression, insomnia is associated with decreased ability to learn associations between neutral stimuli and rewarding outcomes and/or modify behavior in response to differential receipt of reward. This attenuated reward learning may contribute to clinically meaningful decreases in motivation and increased withdrawal in this comorbid group. Results extend existing theory by highlighting impairments in reward learning specifically as a potential mediator of the association between insomnia and depression.PMID:33634765 | DOI:10.1017/S003329172100026X (Source: Psychological Medicine)
Source: Psychological Medicine - February 26, 2021 Category: Psychiatry Authors: Gabrielle I Liverant Kimberly A Arditte Hall Sarah T Wieman Suzanne L Pineles Diego A Pizzagalli Source Type: research

Comparative efficacy and acceptability of expressive writing treatments compared with psychotherapy, other writing treatments, and waiting list control for adult trauma survivors: a systematic review and network meta-analysis
CONCLUSIONS: The summarized evidence confirms that writing treatments may contribute to improving PTSD symptoms in medium to long-term. Methodological issues in the available evidence hamper definite conclusions regarding the comparative efficacy and acceptability of writing treatments. Adequately sized comparative randomized controlled trials preferably including all four active treatment approaches, reporting long-term data, and including researchers with balanced preferences are needed.PMID:33634766 | DOI:10.1017/S0033291721000143 (Source: Psychological Medicine)
Source: Psychological Medicine - February 26, 2021 Category: Psychiatry Authors: Heike Gerger Christoph Patrick Werner Jens Gaab Pim Cuijpers Source Type: research

The relation of depression with structural brain abnormalities and cognitive functioning: the Maastricht study
CONCLUSIONS: MDD is associated with more impaired information processing speed and executive functioning & attention, and overall cognitive impairment. Furthermore, MDD was associated with CSVD in participants without type 2 diabetes, but this association did not explain an impaired cognitive profile.PMID:33634767 | DOI:10.1017/S0033291721000222 (Source: Psychological Medicine)
Source: Psychological Medicine - February 26, 2021 Category: Psychiatry Authors: Anouk F J Geraets Miranda T Schram Jacobus F A Jansen Annemarie Koster Pieter C Dagnelie Marleen M J van Greevenbroek Coen D A Stehouwer Frans R J Verhey Sebastian K öhler Source Type: research

Attention allocation in posttraumatic stress disorder: an eye-tracking study
CONCLUSIONS: Sustained attention on negatively-valenced stimuli emerges as a potential target for therapeutic intervention in PTSD designed to divert attention away from negatively-valenced stimuli and toward neutral ones.PMID:33634768 | DOI:10.1017/S0033291721000581 (Source: Psychological Medicine)
Source: Psychological Medicine - February 26, 2021 Category: Psychiatry Authors: Amit Lazarov Benjamin Suarez-Jimenez Xi Zhu Daniel S Pine Yair Bar-Haim Yuval Neria Source Type: research

PTSD in prison settings: the need for direct comparisons with the general population
Psychol Med. 2021 Feb 26:1-3. doi: 10.1017/S0033291721000507. Online ahead of print.NO ABSTRACTPMID:33634769 | DOI:10.1017/S0033291721000507 (Source: Psychological Medicine)
Source: Psychological Medicine - February 26, 2021 Category: Psychiatry Authors: Thomas Fovet Marielle Wathelet Ali Amad Mathilde Horn Bettina Belet Jean-Luc Roelandt Pierre Thomas Guillaume Vaiva Fabien D'Hondt Source Type: research

Genetic contributions to autism spectrum disorder
Psychol Med. 2021 Feb 26:1-14. doi: 10.1017/S0033291721000192. Online ahead of print.ABSTRACTAutism spectrum disorder (autism) is a heterogeneous group of neurodevelopmental conditions characterized by early childhood-onset impairments in communication and social interaction alongside restricted and repetitive behaviors and interests. This review summarizes recent developments in human genetics research in autism, complemented by epigenetic and transcriptomic findings. The clinical heterogeneity of autism is mirrored by a complex genetic architecture involving several types of common and rare variants, ranging from point m...
Source: Psychological Medicine - February 26, 2021 Category: Psychiatry Authors: A Havdahl M Niarchou A Starnawska M Uddin C van der Merwe V Warrier Source Type: research

Investigating Data-driven Biological Subtypes of Psychiatric Disorders Using Specification-Curve Analysis - ERRATUM
Psychol Med. 2021 Feb 26:1. doi: 10.1017/S0033291721000660. Online ahead of print.NO ABSTRACTPMID:33632352 | DOI:10.1017/S0033291721000660 (Source: Psychological Medicine)
Source: Psychological Medicine - February 26, 2021 Category: Psychiatry Authors: Lian Beijers Hanna M van Loo Jan-Willem Romeijn Femke Lamers Robert A Schoevers Klaas J Wardenaar Source Type: research

Predicting suicidal ideation in a nationally representative sample of young adults: a 12-month prospective study
CONCLUSIONS: The current findings highlight the importance of targeting perceived burdensomeness and internal entrapment to reduce the likelihood that suicidal ideation emerges in at risk individuals.PMID:33634764 | DOI:10.1017/S0033291720005255 (Source: Psychological Medicine)
Source: Psychological Medicine - February 26, 2021 Category: Psychiatry Authors: Karen Wetherall Seonaid Cleare Sarah Eschle Eamonn Ferguson Daryl B O'Connor Ronan E O'Carroll Rory C O'Connor Source Type: research

Associations between insomnia and reward learning in clinical depression
CONCLUSIONS: Among individuals with depression, insomnia is associated with decreased ability to learn associations between neutral stimuli and rewarding outcomes and/or modify behavior in response to differential receipt of reward. This attenuated reward learning may contribute to clinically meaningful decreases in motivation and increased withdrawal in this comorbid group. Results extend existing theory by highlighting impairments in reward learning specifically as a potential mediator of the association between insomnia and depression.PMID:33634765 | DOI:10.1017/S003329172100026X (Source: Psychological Medicine)
Source: Psychological Medicine - February 26, 2021 Category: Psychiatry Authors: Gabrielle I Liverant Kimberly A Arditte Hall Sarah T Wieman Suzanne L Pineles Diego A Pizzagalli Source Type: research

Comparative efficacy and acceptability of expressive writing treatments compared with psychotherapy, other writing treatments, and waiting list control for adult trauma survivors: a systematic review and network meta-analysis
CONCLUSIONS: The summarized evidence confirms that writing treatments may contribute to improving PTSD symptoms in medium to long-term. Methodological issues in the available evidence hamper definite conclusions regarding the comparative efficacy and acceptability of writing treatments. Adequately sized comparative randomized controlled trials preferably including all four active treatment approaches, reporting long-term data, and including researchers with balanced preferences are needed.PMID:33634766 | DOI:10.1017/S0033291721000143 (Source: Psychological Medicine)
Source: Psychological Medicine - February 26, 2021 Category: Psychiatry Authors: Heike Gerger Christoph Patrick Werner Jens Gaab Pim Cuijpers Source Type: research

The relation of depression with structural brain abnormalities and cognitive functioning: the Maastricht study
CONCLUSIONS: MDD is associated with more impaired information processing speed and executive functioning & attention, and overall cognitive impairment. Furthermore, MDD was associated with CSVD in participants without type 2 diabetes, but this association did not explain an impaired cognitive profile.PMID:33634767 | DOI:10.1017/S0033291721000222 (Source: Psychological Medicine)
Source: Psychological Medicine - February 26, 2021 Category: Psychiatry Authors: Anouk F J Geraets Miranda T Schram Jacobus F A Jansen Annemarie Koster Pieter C Dagnelie Marleen M J van Greevenbroek Coen D A Stehouwer Frans R J Verhey Sebastian K öhler Source Type: research

Attention allocation in posttraumatic stress disorder: an eye-tracking study
CONCLUSIONS: Sustained attention on negatively-valenced stimuli emerges as a potential target for therapeutic intervention in PTSD designed to divert attention away from negatively-valenced stimuli and toward neutral ones.PMID:33634768 | DOI:10.1017/S0033291721000581 (Source: Psychological Medicine)
Source: Psychological Medicine - February 26, 2021 Category: Psychiatry Authors: Amit Lazarov Benjamin Suarez-Jimenez Xi Zhu Daniel S Pine Yair Bar-Haim Yuval Neria Source Type: research

PTSD in prison settings: the need for direct comparisons with the general population
Psychol Med. 2021 Feb 26:1-3. doi: 10.1017/S0033291721000507. Online ahead of print.NO ABSTRACTPMID:33634769 | DOI:10.1017/S0033291721000507 (Source: Psychological Medicine)
Source: Psychological Medicine - February 26, 2021 Category: Psychiatry Authors: Thomas Fovet Marielle Wathelet Ali Amad Mathilde Horn Bettina Belet Jean-Luc Roelandt Pierre Thomas Guillaume Vaiva Fabien D'Hondt Source Type: research

Genetic contributions to autism spectrum disorder
Psychol Med. 2021 Feb 26:1-14. doi: 10.1017/S0033291721000192. Online ahead of print.ABSTRACTAutism spectrum disorder (autism) is a heterogeneous group of neurodevelopmental conditions characterized by early childhood-onset impairments in communication and social interaction alongside restricted and repetitive behaviors and interests. This review summarizes recent developments in human genetics research in autism, complemented by epigenetic and transcriptomic findings. The clinical heterogeneity of autism is mirrored by a complex genetic architecture involving several types of common and rare variants, ranging from point m...
Source: Psychological Medicine - February 26, 2021 Category: Psychiatry Authors: A Havdahl M Niarchou A Starnawska M Uddin C van der Merwe V Warrier Source Type: research

Investigating Data-driven Biological Subtypes of Psychiatric Disorders Using Specification-Curve Analysis - ERRATUM
Psychol Med. 2021 Feb 26:1. doi: 10.1017/S0033291721000660. Online ahead of print.NO ABSTRACTPMID:33632352 | DOI:10.1017/S0033291721000660 (Source: Psychological Medicine)
Source: Psychological Medicine - February 26, 2021 Category: Psychiatry Authors: Lian Beijers Hanna M van Loo Jan-Willem Romeijn Femke Lamers Robert A Schoevers Klaas J Wardenaar Source Type: research

Association between the glyco-metabolic adverse effects of antipsychotic drugs and their chemical and pharmacological profile: a network meta-analysis and regression
CONCLUSIONS: Drug rankings may guide antipsychotic switching toward metabolically safer drugs. Mechanistic insights may suggest improvements for combination therapies and drug development. More data are required regarding newer antipsychotics.PMID:33622426 | DOI:10.1017/S0033291721000180 (Source: Psychological Medicine)
Source: Psychological Medicine - February 24, 2021 Category: Psychiatry Authors: Carla Carnovale Ersilia Lucenteforte Vera Battini Faizan Mazhar Marco Fornili Elena Invernizzi Giulia Mosini Michele Gringeri Annalisa Capuano Cristina Scavone Maria Nobile Chiara Vantaggiato Simone Pisano Carmela Bravaccio Sonia Radice Emilio Clementi Ma Source Type: research

Antisaccade error rates and gap effects in psychosis syndromes from bipolar-schizophrenia network for intermediate phenotypes 2 (B-SNIP2)
CONCLUSIONS: With basic prosaccade mechanisms intact, the higher speed-performance tradeoff cost for antisaccade performance in psychosis cases indicates a deficit that is specific to the higher-order cognitive aspects of saccade generation.PMID:33622437 | DOI:10.1017/S003329172000478X (Source: Psychological Medicine)
Source: Psychological Medicine - February 24, 2021 Category: Psychiatry Authors: Ling-Yu Huang Brooke S Jackson Amanda L Rodrigue Carol A Tamminga Elliot S Gershon Godfrey D Pearlson Matcheri S Keshavan Sarah S Keedy S Kristian Hill John A Sweeney Brett A Clementz Jennifer E McDowell Source Type: research

Association between the glyco-metabolic adverse effects of antipsychotic drugs and their chemical and pharmacological profile: a network meta-analysis and regression
CONCLUSIONS: Drug rankings may guide antipsychotic switching toward metabolically safer drugs. Mechanistic insights may suggest improvements for combination therapies and drug development. More data are required regarding newer antipsychotics.PMID:33622426 | DOI:10.1017/S0033291721000180 (Source: Psychological Medicine)
Source: Psychological Medicine - February 24, 2021 Category: Psychiatry Authors: Carla Carnovale Ersilia Lucenteforte Vera Battini Faizan Mazhar Marco Fornili Elena Invernizzi Giulia Mosini Michele Gringeri Annalisa Capuano Cristina Scavone Maria Nobile Chiara Vantaggiato Simone Pisano Carmela Bravaccio Sonia Radice Emilio Clementi Ma Source Type: research

Antisaccade error rates and gap effects in psychosis syndromes from bipolar-schizophrenia network for intermediate phenotypes 2 (B-SNIP2)
CONCLUSIONS: With basic prosaccade mechanisms intact, the higher speed-performance tradeoff cost for antisaccade performance in psychosis cases indicates a deficit that is specific to the higher-order cognitive aspects of saccade generation.PMID:33622437 | DOI:10.1017/S003329172000478X (Source: Psychological Medicine)
Source: Psychological Medicine - February 24, 2021 Category: Psychiatry Authors: Ling-Yu Huang Brooke S Jackson Amanda L Rodrigue Carol A Tamminga Elliot S Gershon Godfrey D Pearlson Matcheri S Keshavan Sarah S Keedy S Kristian Hill John A Sweeney Brett A Clementz Jennifer E McDowell Source Type: research

Poverty transitions in severe mental illness: longitudinal analysis of social drift in China, 1994-2015
CONCLUSIONS: This study shows long-term evidence on the social drift of persons with SMI during the period of rapid social development in China. Further targeted poverty alleviation interventions should be crucial for improving treatment and mental recovery and alleviating poverty related to SMI.PMID:33618792 | DOI:10.1017/S0033291721000350 (Source: Psychological Medicine)
Source: Psychological Medicine - February 23, 2021 Category: Psychiatry Authors: Yue-Hui Yu Wei Luo Bo Liu Wei-Hong Kuang Larry Davidson Cecilia Lai Wan Chan Lin Lu Meng-Ze Xiang Mao-Sheng Ran Source Type: research

Poverty transitions in severe mental illness: longitudinal analysis of social drift in China, 1994-2015
CONCLUSIONS: This study shows long-term evidence on the social drift of persons with SMI during the period of rapid social development in China. Further targeted poverty alleviation interventions should be crucial for improving treatment and mental recovery and alleviating poverty related to SMI.PMID:33618792 | DOI:10.1017/S0033291721000350 (Source: Psychological Medicine)
Source: Psychological Medicine - February 23, 2021 Category: Psychiatry Authors: Yue-Hui Yu Wei Luo Bo Liu Wei-Hong Kuang Larry Davidson Cecilia Lai Wan Chan Lin Lu Meng-Ze Xiang Mao-Sheng Ran Source Type: research

Genetic architecture of Tourette syndrome: our current understanding
Psychol Med. 2021 Feb 22:1-9. doi: 10.1017/S0033291721000234. Online ahead of print.ABSTRACTTourette syndrome (TS) is a severe neuropsychiatric disorder characterized by recurrent, involuntary physical and verbal tics. With a prevalence as high as 1% in children, a deeper understanding of the etiology of the disorder and contributions to risk is critical. Here, we cover the current body of knowledge in scientific literature regarding the genetics of TS. We first review the history and diagnostic criteria for TS cases. We then cover the prevalence, and begin to address the etiology of the disorder. We highlight long-standin...
Source: Psychological Medicine - February 22, 2021 Category: Psychiatry Authors: Laura Dom ènech Carolina Cappi Matt Halvorsen Source Type: research

Altered neural activities during response inhibition in adults with addiction: a voxel-wise meta-analysis
CONCLUSION: This meta-analysis revealed altered activation of FPN, VAN and the cerebellum in adults with addiction during response inhibition tasks using non-addiction-related stimuli. Although FPN and VAN showed lower activity, the cerebellum exhibited stronger activity. These results may help to understand the neural pathology of response inhibition in addiction.PMID:33612127 | DOI:10.1017/S0033291721000362 (Source: Psychological Medicine)
Source: Psychological Medicine - February 22, 2021 Category: Psychiatry Authors: Zeguo Qiu Junjing Wang Source Type: research

Precision psychiatry: promise for the future or rehash of a fossilised foundation?
Psychol Med. 2021 Feb 22:1-3. doi: 10.1017/S0033291721000271. Online ahead of print.ABSTRACTPrecision psychiatry is currently described as an approach that would bring significant advance to psychiatric clinical practice. Theaim of this article is to investigate Precision Psychiatry's promise for the future; should we substantially invest in this new approach? Thearticle is based on a review of the literature and reports a conceptual analysis. A critical examination of Precision Psychiatry's foundationsshows us that its fundaments are obsolete and flawed: we cannot reduce mental suffering to essences in biology. It is prob...
Source: Psychological Medicine - February 22, 2021 Category: Psychiatry Authors: Annemarie C J K öhne Jim van Os Source Type: research

Comparison of different scoring methods based on latent variable models of the PHQ-9: an individual participant data meta-analysis
CONCLUSIONS: In a comprehensive dataset of diagnostic studies, scoring using complex latent variable models do not improve screening accuracy of the PHQ-9 meaningfully as compared to the simple sum score approach.PMID:33612144 | DOI:10.1017/S0033291721000131 (Source: Psychological Medicine)
Source: Psychological Medicine - February 22, 2021 Category: Psychiatry Authors: Felix Fischer Brooke Levis Carl Falk Ying Sun John P A Ioannidis Pim Cuijpers Ian Shrier Andrea Benedetti Brett D Thombs Depression Screening Data (DEPRESSD) PHQ Collaboration Source Type: research

Inflammation is correlated with abnormal functional connectivity in unmedicated bipolar depression: an independent component analysis study of resting-state fMRI
CONCLUSIONS: Our findings that serum IL-8 levels are associated with impaired FC in the right precentral gyrus in BD II patients suggest that inflammation might play a crucial role in brain functional abnormalities in BD.PMID:33602352 | DOI:10.1017/S003329172100009X (Source: Psychological Medicine)
Source: Psychological Medicine - February 19, 2021 Category: Psychiatry Authors: Guixian Tang Pan Chen Guanmao Chen Shuming Zhong JiaYing Gong Hui Zhong Tao Ye Feng Chen Jurong Wang Zhenye Luo Zhangzhang Qi Yanbin Jia Ying Wang Li Huang Source Type: research

Demographic and clinical variables associated with response to clozapine in schizophrenia: a systematic review and meta-analysis
Psychol Med. 2021 Feb 19:1-11. doi: 10.1017/S0033291721000246. Online ahead of print.ABSTRACTClozapine is the only licensed pharmacotherapy for treatment-resistant schizophrenia. However, response to clozapine is variable. Understanding the demographic and clinical features associated with response to clozapine may be useful for patient stratification for clinical trials or for identifying patients for earlier initiation of clozapine. We systematically reviewed the literature to investigate clinical and demographic factors associated with variation in clozapine response in treatment-resistant patients with schizophrenia sp...
Source: Psychological Medicine - February 19, 2021 Category: Psychiatry Authors: Kira Griffiths Edward Millgate Alice Egerton James H MacCabe Source Type: research

Longitudinal courses of suicidal ideation in U.S. military veterans: a 7-year population-based, prospective cohort study
CONCLUSION: Nearly one-in-five veterans reported SI over a 7-year period, most of whom evidenced new onset or remitted SI courses. Chronic and remitted SI may represent particularly high-risk SI courses; the former was associated with higher rates of prospective SA, and psychiatric and physical distress, and the latter with increased likelihood of prior SA, and isolation from social and mental health supports. Physical disability, MDD/PTSD, and recent stressors may be important precipitating or maintaining factors of SI, while social connectedness may be a key target for suicide prevention efforts.PMID:33602367 | DOI:10.10...
Source: Psychological Medicine - February 19, 2021 Category: Psychiatry Authors: Sarah Herzog Jack Tsai Brandon Nichter Lorig Kachadourian Ilan Harpaz-Rotem Robert H Pietrzak Source Type: research

Prospective relationships of adolescents' screen-based sedentary behaviour with depressive symptoms: the Millennium Cohort Study
CONCLUSIONS: Different types of screen-time may have contrasting associations with depressive symptoms during adolescence. Initiatives to address adolescents' screen-time may require targeted approaches.PMID:33602369 | DOI:10.1017/S0033291721000258 (Source: Psychological Medicine)
Source: Psychological Medicine - February 19, 2021 Category: Psychiatry Authors: A Kandola N Owen D W Dunstan M Hallgren Source Type: research

The role of lifetime stressors in adult fibromyalgia: systematic review and meta-analysis of case-control studies
CONCLUSIONS: This study confirmed a significant association between stressor exposure and adult fibromyalgia with the strongest associations observed for physical abuse. Limitations related to current available literature were identified; we provide several suggestions for how these can be addressed in future studies. Stressors are likely to be one of many risk factors for fibromyalgia which we argue is best approached from a biopsychosocial perspective.PMID:33602373 | DOI:10.1017/S0033291720004547 (Source: Psychological Medicine)
Source: Psychological Medicine - February 19, 2021 Category: Psychiatry Authors: Nia Kaleycheva Alexis E Cullen Robyn Evans Tirril Harris Timothy Nicholson Trudie Chalder Source Type: research

Inflammation is correlated with abnormal functional connectivity in unmedicated bipolar depression: an independent component analysis study of resting-state fMRI.
CONCLUSIONS: Our findings that serum IL-8 levels are associated with impaired FC in the right precentral gyrus in BD II patients suggest that inflammation might play a crucial role in brain functional abnormalities in BD. PMID: 33602352 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - February 19, 2021 Category: Psychiatry Authors: Tang G, Chen P, Chen G, Zhong S, Gong J, Zhong H, Ye T, Chen F, Wang J, Luo Z, Qi Z, Jia Y, Wang Y, Huang L Tags: Psychol Med Source Type: research

Demographic and clinical variables associated with response to clozapine in schizophrenia: a systematic review and meta-analysis.
Abstract Clozapine is the only licensed pharmacotherapy for treatment-resistant schizophrenia. However, response to clozapine is variable. Understanding the demographic and clinical features associated with response to clozapine may be useful for patient stratification for clinical trials or for identifying patients for earlier initiation of clozapine. We systematically reviewed the literature to investigate clinical and demographic factors associated with variation in clozapine response in treatment-resistant patients with schizophrenia spectrum disorders. Subsequently, we performed a random-effects meta-analysis...
Source: Psychological Medicine - February 19, 2021 Category: Psychiatry Authors: Griffiths K, Millgate E, Egerton A, MacCabe JH Tags: Psychol Med Source Type: research