Response to 'The association of clozapine and haematological malignancies needs to be replicated by other studies and more importantly by analyses of subsamples from VigiBase'.
lle C PMID: 32635951 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 8, 2020 Category: Psychiatry Authors: Chrétien B, Lelong-Boulouard V, Alexandre J, Fedrizzi S, Dolladille C Tags: Psychol Med Source Type: research

Suicidal ideation and attempts following nonmedical use of prescription opioids and related disorder.
CONCLUSIONS: Heavy/frequent opioid use and related disorder were associated with prevalent suicide attempts; opioid use disorder was also associated with the incident and prevalent suicidal ideation. Given population increases in nonmedical use of prescription opioids and disorder, the opioid crisis may have contributed to population increases in suicidal ideation. PMID: 32635959 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 8, 2020 Category: Psychiatry Authors: Santaella-Tenorio J, Martins SS, Cerdá M, Olfson M, Keyes KM Tags: Psychol Med Source Type: research

Preventing depression using a smartphone app: a randomized controlled trial.
CONCLUSIONS: This trial demonstrates that a smartphone app can reduce depression symptoms and potentially prevent incident depression caseness and such interventions may have a role in improving working population mental health. Some caution in interpretation is needed regarding the clinical significance due to small effect size and trial attrition.Trial Registration Australian and New Zealand Clinical Trials Registry (www.anzctr.org.au/) ACTRN12617000548336. PMID: 32624013 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 6, 2020 Category: Psychiatry Authors: Deady M, Glozier N, Calvo R, Johnston D, Mackinnon A, Milne D, Choi I, Gayed A, Peters D, Bryant R, Christensen H, Harvey SB Tags: Psychol Med Source Type: research

Familial risk for depressive and anxiety disorders: associations with genetic, clinical, and psychosocial vulnerabilities.
CONCLUSIONS: Familial risk for depression and anxiety deserves clinical attention due to its associated genetic vulnerability and more unfavorable disease profile, and seems to be better captured by a continuous score that incorporates family- and disorder-specific characteristics than by a dichotomous FH measure. PMID: 32624018 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 6, 2020 Category: Psychiatry Authors: van Sprang ED, Maciejewski DF, Milaneschi Y, Elzinga BM, Beekman ATF, Hartman CA, van Hemert AM, Penninx BWJH Tags: Psychol Med Source Type: research

Depression with atypical neurovegetative symptoms shares genetic predisposition with immuno-metabolic traits and alcohol consumption.
CONCLUSIONS: ↑WS depression shows evidence of distinct genetic predisposition to immune-metabolic traits and alcohol consumption. These genetic signals suggest that biological targets including immune-cardio-metabolic pathways may be relevant to therapies in individuals with ↑WS depression. PMID: 32624019 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 6, 2020 Category: Psychiatry Authors: Badini I, Coleman JRI, Hagenaars SP, Hotopf M, Breen G, Lewis CM, Fabbri C Tags: Psychol Med Source Type: research

Childhood adversity and psychosis: a systematic review of bio-psycho-social mediators and moderators.
Abstract The association between childhood adversity (CA) and psychosis has been extensively investigated in recent years. An increasing body of research has also focused on the mediating or moderating role of biological and psychological mechanisms, as well as other risk factors that might account for the link between CA and psychosis. We conducted a systematic search of the PsychINFO, Embase, Ovid, and Web of Science databases for original articles investigating the role of genetic vulnerabilities, environmental factors, psychological and psychopathological mechanisms in the association between CA and psychosis ...
Source: Psychological Medicine - July 6, 2020 Category: Psychiatry Authors: Sideli L, Murray RM, Schimmenti A, Corso M, La Barbera D, Trotta A, Fisher HL Tags: Psychol Med Source Type: research

The effects of callous-unemotional traits and aggression subtypes on amygdala activity in response to negative faces.
CONCLUSIONS: Our results showed differences in amygdala activity and SC responses to emotional faces between cases with ODD/CD and TD, while CU traits moderate both central (amygdala) and peripheral (SC) responses. Our insights regarding subtypes and trait-specific aggression could be used for improved diagnostics and personalized treatment. PMID: 32624021 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 6, 2020 Category: Psychiatry Authors: Aggensteiner PM, Holz NE, Böttinger BW, Baumeister S, Hohmann S, Werhahn JE, Naaijen J, Ilbegi S, Glennon JC, Hoekstra PJ, Dietrich A, Deters RK, Saam MC, Schulze UME, Lythgoe DJ, Sethi A, Craig MC, Mastroianni M, Sagar-Ouriaghli I, Santosh PJ, Rosa M, B Tags: Psychol Med Source Type: research

The Psychological Impact of COVID-19 Pandemic on Medical Staff in Guangdong, China: A Cross-Sectional Study.
PMID: 32624037 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 6, 2020 Category: Psychiatry Authors: Wang H, Huang D, Huang H, Zhang J, Guo L, Liu Y, Ma H, Geng Q Tags: Psychol Med Source Type: research

The Silent Danger of Social Distancing.
PMID: 32624043 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 6, 2020 Category: Psychiatry Authors: Aleman A, Sommer I Tags: Psychol Med Source Type: research

COVID-19 Lockdown and Mental Health: Why We Must Look Into Oncology Units.
PMID: 32616099 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 3, 2020 Category: Psychiatry Authors: Croizier C, Bouillon-Minois JB, Bay JO, Dutheil F Tags: Psychol Med Source Type: research

Subtyping late-life depression according to inflammatory and metabolic dysregulation: a prospective study.
CONCLUSIONS: Nearly half of the patients with late-life depressions suffer from metabolic-inflammatory dysregulation, which is also associated with more severe depression and a worse prognosis. Future studies should examine whether these depressed older patients benefit from a metabolic-inflammatory targeted treatment. PMID: 32618234 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 3, 2020 Category: Psychiatry Authors: Kokkeler KJE, Marijnissen RM, Wardenaar KJ, Rhebergen D, van den Brink RHS, van der Mast RC, Oude Voshaar RC Tags: Psychol Med Source Type: research

Non-presentation at hospital following a suicide attempt: a national survey.
CONCLUSIONS: This survey at a national level confirmed that a large proportion of individuals does not go to the hospital and does not meet any health care professionals following a suicidal act. Assessment of unmet needs is necessary. PMID: 32618240 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 3, 2020 Category: Psychiatry Authors: Jollant F, Hawton K, Vaiva G, Chan-Chee C, du Roscoat E, Leon C Tags: Psychol Med Source Type: research

Event-related brain-oscillatory and ex-Gaussian markers of remission and persistence of ADHD.
CONCLUSIONS: We found widespread impairments in ADHD persisters in reaction-time distribution and brain-oscillatory measures. Event-related theta power, theta phase consistency and tau across conditions, as well as mu in the more engaging fast-incentive condition, emerged as novel markers of ADHD remission, potentially representing compensatory mechanisms in individuals with remitted ADHD. PMID: 32611469 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 2, 2020 Category: Psychiatry Authors: Vainieri I, Michelini G, Adamo N, Cheung CHM, Asherson P, Kuntsi J Tags: Psychol Med Source Type: research

Examining unique and prospective relationships among self-injurious thoughts and behaviors and posttraumatic stress disorder: a network analysis in two trauma-exposed samples.
CONCLUSIONS: Overall, our results suggest that treatments targeting negative beliefs and risky behaviors may prevent SITB in community and Veteran populations, whereas treatments targeting distorted blame and unwanted memories may help reduce SITB for individuals with a history of combat trauma. PMID: 32605688 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 1, 2020 Category: Psychiatry Authors: Spitzer EG, Benfer N, Zuromski KL, Marx BP, Witte TK Tags: Psychol Med Source Type: research

Empirically determined severity levels for binge-eating disorder outperform existing severity classification schemes.
Abstract BACKGROUND: Eating-disorder severity indicators should theoretically index symptom intensity, impairment, and level of needed treatment. Two severity indicators for binge-eating disorder (BED) have been proposed (categories of binge-eating frequency and shape/weight overvaluation) but have mixed empirical support including modest clinical utility. This project uses structural equation model (SEM) trees - a form of exploratory data mining - to empirically determine the precise levels of binge-eating frequency and/or shape/weight overvaluation that most significantly differentiate BED severities. METHO...
Source: Psychological Medicine - June 30, 2020 Category: Psychiatry Authors: Forrest LN, Jacobucci RC, Grilo CM Tags: Psychol Med Source Type: research

When expanding training from working memory to emotional working memory: not only improving explicit emotion regulation but also implicit negative control for anxious individuals.
CONCLUSIONS: The general WM-T was effective in enhancing explicit emotional regulation, while training with emotional add-in further improved implicit emotional control. (E)WM-T shows potential as a beneficial intervention for the anxiety population. PMID: 32600499 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 30, 2020 Category: Psychiatry Authors: Pan DN, Hoid D, Wang XB, Jia Z, Li X Tags: Psychol Med Source Type: research

Day hospital versus intensive outpatient mentalization-based treatment: 3-year follow-up of patients treated for borderline personality disorder in a multicentre randomized clinical trial.
CONCLUSIONS: Patients in both conditions showed similar large improvements over the course of 36 months, despite large differences in treatment intensity. MBT-DH and MBT-IOP were associated with different trajectories of change. Cost-effectiveness considerations and predictors of differential treatment outcome may further inform optimal treatment selection. PMID: 32602830 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 30, 2020 Category: Psychiatry Authors: Smits ML, Feenstra DJ, Bales DL, Blankers M, Dekker JJM, Lucas Z, Kamphuis JH, Busschbach JJV, Verheul R, Luyten P Tags: Psychol Med Source Type: research

Micro-level de-coupling of negative affect and binge eating in relationship to macro-level outcomes in binge eating disorder treatment.
CONCLUSIONS: Both ICAT-BED and CBTgsh were associated with de-coupling of momentary negative affect and binge-eating symptoms, which in turn relate to cognitive and behavioral treatment outcomes. Future research is warranted to identify differential mechanisms of change across ICAT-BED and CBTgsh. Results also highlight the importance of developing momentary interventions to more effectively de-couple negative affect and binge eating. PMID: 32597737 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 29, 2020 Category: Psychiatry Authors: Smith KE, Mason TB, Schaefer LM, Anderson LM, Hazzard VM, Crosby RD, Engel SG, Crow SJ, Wonderlich SA, Peterson CB Tags: Psychol Med Source Type: research

The perinatal origins of childhood anxiety disorders and the role of early-life maternal predictors.
CONCLUSIONS: This study suggests the importance of maternal factors pre-conception, pregnancy and in the postnatal period, which predict CADs and this is consistent with a developmental programming hypothesis for CAD. PMID: 32597740 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 29, 2020 Category: Psychiatry Authors: Galbally M, Watson SJ, van Rossum EFC, Chen W, de Kloet ER, Lewis AJ Tags: Psychol Med Source Type: research

The relationship between physical activity, BMI, circadian rhythm, and sleep with cognition in bipolar disorder.
CONCLUSIONS: This study suggests that there is an association between sleep abnormalities and cognition in BD, with little or no relationship with physical activity, BMI, and circadian rhythm. PMID: 32597742 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 29, 2020 Category: Psychiatry Authors: Burgess JL, Bradley AJ, Anderson KN, Gallagher P, McAllister-Williams RH Tags: Psychol Med Source Type: research

Combined impact of ADHD and insomnia symptoms on quality of life, productivity, and health care use in the general population.
CONCLUSIONS: People with both ADHD and sleep problems have increased risk for poorer mental functioning and productivity loss. These results underscore the importance of screening for sleep problems when ADHD symptoms are present, and vice versa, and to target both disorders during treatment. PMID: 32597743 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 29, 2020 Category: Psychiatry Authors: van Andel E, Ten Have M, Bijlenga D, Beekman ATF, de Graaf R, Sandra Kooij JJ Tags: Psychol Med Source Type: research

Association of parental substance misuse with offspring substance misuse and criminality: a genetically informed register-based study.
CONCLUSIONS: Our findings from a large offspring-of-siblings study indicate that shared genetic influences mostly explain the associations between parental substance misuse and both offspring substance misuse and criminality, but we also found evidence for the contribution of environmental factors shared by members of nuclear and extended families. PMID: 32597745 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 29, 2020 Category: Psychiatry Authors: Latvala A, Kuja-Halkola R, D'Onofrio BM, Jayaram-Lindström N, Larsson H, Lichtenstein P Tags: Psychol Med Source Type: research

Refining our understanding of depressive states and state transitions in response to cognitive behavioural therapy using latent Markov modelling.
CONCLUSIONS: This study presents a novel approach for depression sub-typing, defining fluid depressive states and exploring transitions between states in response to CBT. Understanding how different symptom profiles respond to therapy will inform the development and delivery of stratified treatment protocols, improving clinical outcomes and cost-effectiveness of psychological therapies for patients with depression. PMID: 32597747 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 29, 2020 Category: Psychiatry Authors: Catarino A, Fawcett JM, Ewbank MP, Bateup S, Cummins R, Tablan V, Blackwell AD Tags: Psychol Med Source Type: research

Interaction of irritability and anxiety on emotional responding and emotion regulation: a functional MRI study.
CONCLUSIONS: Atypical maintenance of emotional stimuli within the rostro-medial prefrontal cortex may exacerbate the difficulties faced by adolescents with irritability. Moreover, increased anxiety combined with significant irritability may disrupt an automatic emotional conflict-based form of emotion regulation that is particularly associated with the ventral anterior cingulate cortex. PMID: 32584213 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 25, 2020 Category: Psychiatry Authors: Crum KI, Hwang S, Blair KS, Aloi JM, Meffert H, White SF, Tyler PM, Leibenluft E, Pope K, Blair RJR Tags: Psychol Med Source Type: research

Migrant status and risk of compulsory admission at first diagnosis of psychotic disorder: a population-based cohort study in Sweden.
CONCLUSIONS: Inequalities in the risk of compulsory admission by migrant status, region-of-origin, urban living and own-region migrant density highlight discernible factors which raise barriers to equitable care and provide potential targets for intervention. PMID: 32578529 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 24, 2020 Category: Psychiatry Authors: Terhune J, Dykxhoorn J, Mackay E, Hollander AC, Kirkbride JB, Dalman C Tags: Psychol Med Source Type: research

Brain structural correlates of schizotypal signs and subclinical schizophrenia nuclear symptoms in healthy individuals.
I Abstract BACKGROUND: Subclinical psychotic-like experiences (PLE), resembling key symptoms of psychotic disorders, are common throughout the general population and possibly associated with psychosis risk. There is evidence that such symptoms are also associated with structural brain changes. METHODS: In 672 healthy individuals, we assessed PLE and associated distress with the symptom-checklist-90R (SCL-90R) scales 'schizotypal signs' (STS) and 'schizophrenia nuclear symptoms' (SNS) and analysed associations with voxel- and surfaced-based brain structural parameters derived from structural magnetic resonan...
Source: Psychological Medicine - June 24, 2020 Category: Psychiatry Authors: Meller T, Schmitt S, Ettinger U, Grant P, Stein F, Brosch K, Grotegerd D, Dohm K, Meinert S, Förster K, Hahn T, Jansen A, Dannlowski U, Krug A, Kircher T, Nenadić I Tags: Psychol Med Source Type: research

Emotional Distress in Young Adults During the COVID-19 Pandemic: Evidence of Risk and Resilience From a Longitudinal Cohort Study.
PMID: 32571438 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 23, 2020 Category: Psychiatry Authors: Shanahan L, Steinhoff A, Bechtiger L, Murray AL, Nivette A, Hepp U, Ribeaud D, Eisner M Tags: Psychol Med Source Type: research

Identifying social cognition subgroups in euthymic patients with bipolar disorder: a cluster analytical approach.
CONCLUSIONS: Our results confirmed the existence of two discrete profiles of SC among BD. Nearly two-thirds of patients exhibited adjusted social cognitive abilities. Longer illness duration, male gender, and lower estimated IQ were associated with low SC performance. PMID: 32546284 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 17, 2020 Category: Psychiatry Authors: Varo C, Solé B, Jiménez E, Bonnín CM, Torrent C, Valls E, Lahera G, Martínez-Arán A, Carvalho AF, Miskowiak KW, Vieta E, Reinares M Tags: Psychol Med Source Type: research

Cannabis use and posttraumatic stress disorder: prospective evidence from a longitudinal study of veterans.
CONCLUSIONS: Strong prospective associations capturing within-person changes suggest that cannabis use is linked with greater severity of trauma-related intrusion symptoms over time. A strong person-level directional association between PTSD and CUD was evident. Findings have significant clinical implications for the long-term effects of cannabis use among individuals with PTSD. PMID: 32546286 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 17, 2020 Category: Psychiatry Authors: Metrik J, Stevens AK, Gunn RL, Borsari B, Jackson KM Tags: Psychol Med Source Type: research

Predictors of new onsets of irritable bowel syndrome, chronic fatigue syndrome and fibromyalgia: the lifelines study.
CONCLUSIONS: Syndrome-specific predictors were more common than shared ones and these predictors might form a better starting point to unravel the heterogeneous etiologies of these syndromes than the current approach based on symptom patterns. The close relationship between IBS and FM is striking and requires further research. PMID: 32546287 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 17, 2020 Category: Psychiatry Authors: Monden R, Rosmalen JGM, Wardenaar KJ, Creed F Tags: Psychol Med Source Type: research

Long-term outcome predictors after functional remediation in patients with bipolar disorder.
CONCLUSIONS: Results suggest that patients with better cognitive performance at baseline, especially in terms of verbal memory and executive functions, may present better functional outcomes at long term follow-up after receiving functional remediation. PMID: 32539879 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 16, 2020 Category: Psychiatry Authors: Solé B, Bonnín CM, Radua J, Montejo L, Hogg B, Jimenez E, Reinares M, Valls E, Varo C, Pacchiarotti I, Valentí M, Garriga M, Torres I, Martínez-Arán A, Vieta E, Torrent C Tags: Psychol Med Source Type: research

Long-term behavioural rewriting of maladaptive drinking memories via reconsolidation-update mechanisms.
CONCLUSIONS: The longevity of behavioural interventions designed to reduce problematic drinking levels may be enhanced by leveraging reconsolidation-update mechanisms to rewrite maladaptive memory. However, inter-individual variability in levels of corrective learning is likely to determine the efficacy of reconsolidation-updating interventions and should be considered when designing and assessing interventions. PMID: 32539883 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 16, 2020 Category: Psychiatry Authors: Gale G, Walsh K, Hennessy VE, Stemerding LE, Ni KS, Thomas E, Kamboj SK, Das RK Tags: Psychol Med Source Type: research

Brain imaging in catatonia: systematic review and directions for future research.
CONCLUSION: In catatonia, brain imaging is abnormal in the majority of cases, and abnormalities more frequently diffuse than localised. Brain imaging studies published so far suffer from serious limitations and for now the different models presented in the literature do not explain most of the cases. There is an important need for further studies including a better clinical characterisation of patients with catatonia, functional imaging with concurrent catatonic symptoms and the use of novel brain imaging techniques. PMID: 32539902 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 16, 2020 Category: Psychiatry Authors: Haroche A, Rogers J, Plaze M, Gaillard R, Williams SC, Thomas P, Amad A Tags: Psychol Med Source Type: research

Computing schizophrenia: ethical challenges for machine learning in psychiatry.
Abstract Recent advances in machine learning (ML) promise far-reaching improvements across medical care, not least within psychiatry. While to date no psychiatric application of ML constitutes standard clinical practice, it seems crucial to get ahead of these developments and address their ethical challenges early on. Following a short general introduction concerning ML in psychiatry, we do so by focusing on schizophrenia as a paradigmatic case. Based on recent research employing ML to further the diagnosis, treatment, and prediction of schizophrenia, we discuss three hypothetical case studies of ML applications w...
Source: Psychological Medicine - June 15, 2020 Category: Psychiatry Authors: Starke G, De Clercq E, Borgwardt S, Elger BS Tags: Psychol Med Source Type: research

Challenging the negative learning bias hypothesis of depression: reversal learning in a naturalistic psychiatric sample.
CONCLUSIONS: These results speak against the generalizability of the negative learning bias hypothesis to depressed patients with comorbidities. This study highlights the importance of investigating unselected samples of psychiatric patients, which represent the vast majority of the psychiatric population. PMID: 32538342 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 15, 2020 Category: Psychiatry Authors: Brolsma SCA, Vrijsen JN, Vassena E, Rostami Kandroodi M, Bergman MA, van Eijndhoven PF, Collard RM, den Ouden HEM, Schene AH, Cools R Tags: Psychol Med Source Type: research

Predicting the naturalistic course in anxiety disorders using clinical and biological markers: a machine learning approach.
CONCLUSIONS: The current study showed moderate performance in predicting recovery from anxiety disorders over a 2-year follow-up for individual patients and indicates that anxiety features are most indicative for anxiety improvement and depression features for improvement in general. PMID: 32524918 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 11, 2020 Category: Psychiatry Authors: Bokma WA, Zhutovsky P, Giltay EJ, Schoevers RA, Penninx BWJH, van Balkom ALJM, Batelaan NM, van Wingen GA Tags: Psychol Med Source Type: research

Nitric Oxide Synthase activity in major depressive episodes before and after antidepressant treatment: Results of a large case-control treatment study.
ble E Abstract BACKGROUND: Nitric oxide synthase (NOS) activity, an enzyme potentially involved in the major depressive episodes (MDE), could be indirectly measured by the L-Citrulline/L-Arginine ratio (L-Cit/L-Arg). The aim of this study was: (1) to compare the NOS activity of patients with a MDE to that of healthy controls (HC); (2) to assess its change after antidepressant treatment. METHODS: A total of 460 patients with a current MDE in a context of major depressive disorder (MDD) were compared to 895 HC for NOS activity (L-Cit/L-Arg plasma ratio). L-Arg and L-Cit plasma levels were measured using a MS-ba...
Source: Psychological Medicine - June 11, 2020 Category: Psychiatry Authors: Loeb E, El Asmar K, Trabado S, Gressier F, Colle R, Rigal A, Martin S, Verstuyft C, Fève B, Chanson P, Becquemont L, Corruble E Tags: Psychol Med Source Type: research

A major flaw in the diagnosis of schizophrenia: what happened to the Schneider's first rank symptoms.
Abstract Kurt Schneider introduced in the definition of the first-rank symptoms (FRS) the criterion that, where unequivocally present, the FRS are always psychological primaries and irreducible. This criterion, grounded on 'phenomenology' (description of subjective experiences), cannot be applied, according to Schneider, to delusions, either two-stage FRS delusional perception, or second-rank delusional notions. The Schneider's key criterion was neglected since the initial adoption of the 'Schneider's FRS' in the subsequent international literature (e.g. PSE, RDC, DSM, and ICD). The 'Schneider's FRS' (e.g. thought...
Source: Psychological Medicine - June 11, 2020 Category: Psychiatry Authors: Moscarelli M Tags: Psychol Med Source Type: research

Apathy is associated with white matter network disruption and specific cognitive deficits in Parkinson's disease.
Abstract BACKGROUND: Apathy is common in Parkinson's disease (PD) but its underlying white matter (WM) architecture is not well understood. Moreover, how apathy affects cognitive functions in PD remains unclear. We investigated apathy-related WM network alterations and the impact of apathy on cognition in the context of PD. METHODS: Apathetic PD patients (aPD), non-apathetic PD patients (naPD), and matched healthy controls (HCs) underwent brain scans and clinical assessment. Graph-theoretical and network-based analyses were used for group comparisons of WM features derived from diffusion spectrum imaging (DSI...
Source: Psychological Medicine - June 11, 2020 Category: Psychiatry Authors: Wen MC, Thiery A, Tseng WI, Kok T, Xu Z, Chua ST, Tan LCS Tags: Psychol Med Source Type: research

Sociodemographic moderation of the association between depression and stroke incidence in a retrospective cohort of 0.4 million primary care recipients with hypertension.
CONCLUSION: Depression is more strongly associated with acute stroke incidence among male than female primary care patients with hypertension. More integrated services are warranted to address their needs. PMID: 32524935 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 11, 2020 Category: Psychiatry Authors: Lai FTT, Mercer SW, Guthrie B, Yip BHK, Chung GKK, Zou D, Lee KP, Chau PYK, Chung RY, Wong ELY, Yeoh EK, Wong SYS Tags: Psychol Med Source Type: research

Unit cohesion during deployment and post-deployment mental health: is cohesion an individual- or unit-level buffer for combat-exposed soldiers?
We examined buffering effects associated with two forms of unit cohesion (peer-oriented horizontal cohesion and subordinate-leader vertical cohesion) defined as either individual-level or aggregated unit-level variables. METHODS: Longitudinal survey data from US Army soldiers who deployed to Afghanistan in 2012 were analyzed using mixed-effects regression. Models evaluated individual- and unit-level interaction effects of combat exposure and cohesion during deployment on symptoms of post-traumatic stress disorder (PTSD), depression, and suicidal ideation reported at 3 months post-deployment (model n's = 6684 to 6826)....
Source: Psychological Medicine - June 10, 2020 Category: Psychiatry Authors: Campbell-Sills L, Flynn PJ, Choi KW, Ng THH, Aliaga PA, Broshek C, Jain S, Kessler RC, Stein MB, Ursano RJ, Bliese PD Tags: Psychol Med Source Type: research

Sexual symptoms in post-traumatic stress disorder following childhood sexual abuse: a network analysis.
CONCLUSIONS: Sexual symptoms are highly prevalent in survivors of childhood sexual abuse with post-traumatic stress disorder. Further research is needed regarding the link of difficulties engaging in sexual activities, depression, and post-traumatic stress disorder, as well as regarding the association of dissociation and sexual preferences causing distress. Sexual symptoms require consideration in the treatment of post-traumatic stress disorder following childhood sexual abuse. PMID: 32517829 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 10, 2020 Category: Psychiatry Authors: Kratzer L, Heinz P, Schennach R, Knefel M, Schiepek G, Biedermann SV, Büttner M Tags: Psychol Med Source Type: research

Motivational and cognitive factors linked to community integration in homeless veterans: study 1 - individuals with psychotic disorders.
CONCLUSIONS: The relatively selective associations for motivational measures differ from what is typically seen in psychosis, in which all domains are associated with community integration. These findings are presented along with a partner paper (Study 2) to compare findings from this study to an independent sample without a history of psychotic disorders to evaluate the consistency in findings regarding community integration across projects. PMID: 32517838 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 10, 2020 Category: Psychiatry Authors: Green MF, Wynn JK, Gabrielian S, Hellemann G, Horan WP, Kern RS, Lee J, Marder SR, Sugar CA Tags: Psychol Med Source Type: research

Using major depression polygenic risk scores to explore the depressive symptom continuum.
CONCLUSIONS: An association between MD PRS and a continuous phenotype of depressive symptoms in case- and control-only subsets provides support against a purely categorical phenotype; indicating further insights into MD can be obtained when this within-group variation is considered. The stronger association within cases suggests this variation may be of particular importance. PMID: 32519625 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 10, 2020 Category: Psychiatry Authors: Jermy BS, Hagenaars SP, Glanville KP, Coleman JRI, Howard DM, Breen G, Vassos E, Lewis CM Tags: Psychol Med Source Type: research

Health-protective behaviour, social media usage, and conspiracy belief during the COVID-19 public health emergency.
PMID: 32513320 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 9, 2020 Category: Psychiatry Authors: Allington D, Duffy B, Wessely S, Dhavan N, Rubin J Tags: Psychol Med Source Type: research

Effects of seeking compensation on the psychological health and recovery of injured patients: the role of stress vulnerability and injury-related disability.
Abstract BACKGROUND: Seeking compensation has been shown to have an adverse effect on the psychological health and recovery of injured patients, however, this effect requires clarification. METHODS: A total of 2019 adults sustaining a traffic injury were recruited. Of these, 709 (35.1%) lodged a compensation claim. Interviews occurred at 1-, 6- and 12-month post-injury. Outcomes were psychological distress (posttraumatic stress (PTS) and depressive symptoms) and health-related functioning (HrF) (quality of life measured by EQ-5D-3L and disability by WHODAS) over 12-months post-injury. Covariates included indi...
Source: Psychological Medicine - June 9, 2020 Category: Psychiatry Authors: Pozzato I, Kifley A, Craig A, Gopinath B, Tran Y, Jagnoor J, Cameron ID Tags: Psychol Med Source Type: research

Examining pathways between genetic liability for schizophrenia and patterns of tobacco and cannabis use in adolescence.
CONCLUSIONS: Our study provides evidence that genetic risk for schizophrenia is associated with patterns of cannabis use during adolescence. Investigation of pathways other than the cognitive, emotional, and behavioral phenotypes examined here is required to identify modifiable targets to reduce the public health burden of cannabis use in the population. PMID: 32515721 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 9, 2020 Category: Psychiatry Authors: Jones HJ, Hammerton G, McCloud T, Hines LA, Wright C, Gage SH, Holmans P, Jones PB, Davey Smith G, Linden DEJ, O'Donovan MC, Owen MJ, Walters JT, Munafò MR, Heron J, Zammit S Tags: Psychol Med Source Type: research

We should beware of ignoring uncomfortable possible truths (a reply to McManus).
PMID: 32507116 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 8, 2020 Category: Psychiatry Authors: Freeman D, Waite F, Rosebrock L, Petit A, Causier C, East A, Jenner L, Teale AL, Carr L, Mulhall S, Bold E, Lambe S Tags: Psychol Med Source Type: research

Developmental multi-trajectory of irritability, anxiety, and hyperactivity as psychological markers of heterogeneity in childhood aggression.
CONCLUSIONS: Identified combinations of developmental trajectories of psychological characteristics were associated with different magnitude in risk for exhibiting physical aggression. These results may highlight the heterogeneity of developmental trajectories associated with childhood aggression. PMID: 32498723 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 5, 2020 Category: Psychiatry Authors: Dugré JR, Potvin S Tags: Psychol Med Source Type: research

What you see is what you get: visual scanning failures of naturalistic social scenes in schizophrenia.
Abstract BACKGROUND: Impairments in social cognition contribute significantly to disability in schizophrenia patients (SzP). Perception of facial expressions is critical for social cognition. Intact perception requires an individual to visually scan a complex dynamic social scene for transiently moving facial expressions that may be relevant for understanding the scene. The relationship of visual scanning for these facial expressions and social cognition remains unknown. METHODS: In 39 SzP and 27 healthy controls (HC), we used eye-tracking to examine the relationship between performance on The Awareness of So...
Source: Psychological Medicine - June 5, 2020 Category: Psychiatry Authors: Patel GH, Arkin SC, Ruiz-Betancourt DR, DeBaun HM, Strauss NE, Bartel LP, Grinband J, Martinez A, Berman RA, Leopold DA, Javitt DC Tags: Psychol Med Source Type: research