Proton pump inhibitors may reduce the risk of high-grade dysplasia and/or esophageal adenocarcinoma in Barrett's esophagus: a systematic review and meta-analysis
Expert Rev Clin Pharmacol. 2021 Nov 21. doi: 10.1080/17512433.2022.2008909. Online ahead of print.ABSTRACTBACKGROUND: Barrett's esophagus (BE) is an important risk factor for high-grade dysplasia (HGD) and/or esophageal adenocarcinoma (EAC). The effect of proton pump inhibitors (PPIs) on the chemoprevention of HGD and/or EAC arising from BE remains controversial.RESEARCH DESIGN AND METHODS: PubMed, EMBASE, and Cochrane Library databases were systematically searched. Risk ratios (RRs) or odds ratios (ORs) with 95% confidence intervals (CIs) were pooled by a random-effect model. Heterogeneity and its potential source were as...
Source: Pharmacological Reviews - November 22, 2021 Category: Drugs & Pharmacology Authors: Haijuan Yao Le Wang Hongyu Li Shixue Xu Zhaohui Bai Yanyan Wu Hongxin Chen Hemant Goyal Xingshun Qi Source Type: research

Proton pump inhibitors may reduce the risk of high-grade dysplasia and/or esophageal adenocarcinoma in Barrett's esophagus: a systematic review and meta-analysis
Expert Rev Clin Pharmacol. 2021 Nov 21. doi: 10.1080/17512433.2022.2008909. Online ahead of print.ABSTRACTBACKGROUND: Barrett's esophagus (BE) is an important risk factor for high-grade dysplasia (HGD) and/or esophageal adenocarcinoma (EAC). The effect of proton pump inhibitors (PPIs) on the chemoprevention of HGD and/or EAC arising from BE remains controversial.RESEARCH DESIGN AND METHODS: PubMed, EMBASE, and Cochrane Library databases were systematically searched. Risk ratios (RRs) or odds ratios (ORs) with 95% confidence intervals (CIs) were pooled by a random-effect model. Heterogeneity and its potential source were as...
Source: Pharmacological Reviews - November 22, 2021 Category: Drugs & Pharmacology Authors: Haijuan Yao Le Wang Hongyu Li Shixue Xu Zhaohui Bai Yanyan Wu Hongxin Chen Hemant Goyal Xingshun Qi Source Type: research

Proton pump inhibitors may reduce the risk of high-grade dysplasia and/or esophageal adenocarcinoma in Barrett's esophagus: a systematic review and meta-analysis
Expert Rev Clin Pharmacol. 2021 Nov 21. doi: 10.1080/17512433.2022.2008909. Online ahead of print.ABSTRACTBACKGROUND: Barrett's esophagus (BE) is an important risk factor for high-grade dysplasia (HGD) and/or esophageal adenocarcinoma (EAC). The effect of proton pump inhibitors (PPIs) on the chemoprevention of HGD and/or EAC arising from BE remains controversial.RESEARCH DESIGN AND METHODS: PubMed, EMBASE, and Cochrane Library databases were systematically searched. Risk ratios (RRs) or odds ratios (ORs) with 95% confidence intervals (CIs) were pooled by a random-effect model. Heterogeneity and its potential source were as...
Source: Pharmacological Reviews - November 22, 2021 Category: Drugs & Pharmacology Authors: Haijuan Yao Le Wang Hongyu Li Shixue Xu Zhaohui Bai Yanyan Wu Hongxin Chen Hemant Goyal Xingshun Qi Source Type: research

Proton pump inhibitors may reduce the risk of high-grade dysplasia and/or esophageal adenocarcinoma in Barrett's esophagus: a systematic review and meta-analysis
Expert Rev Clin Pharmacol. 2021 Nov 21. doi: 10.1080/17512433.2022.2008909. Online ahead of print.ABSTRACTBACKGROUND: Barrett's esophagus (BE) is an important risk factor for high-grade dysplasia (HGD) and/or esophageal adenocarcinoma (EAC). The effect of proton pump inhibitors (PPIs) on the chemoprevention of HGD and/or EAC arising from BE remains controversial.RESEARCH DESIGN AND METHODS: PubMed, EMBASE, and Cochrane Library databases were systematically searched. Risk ratios (RRs) or odds ratios (ORs) with 95% confidence intervals (CIs) were pooled by a random-effect model. Heterogeneity and its potential source were as...
Source: Pharmacological Reviews - November 22, 2021 Category: Drugs & Pharmacology Authors: Haijuan Yao Le Wang Hongyu Li Shixue Xu Zhaohui Bai Yanyan Wu Hongxin Chen Hemant Goyal Xingshun Qi Source Type: research

Inhaled < em > β < /em > 2 Adrenergic Agonists and Other cAMP-Elevating Agents: Therapeutics for Alveolar Injury and Acute Respiratory Disease Syndrome?
Pharmacol Rev. 2021 Oct;73(4):488-526. doi: 10.1124/pharmrev.121.000356.ABSTRACTInhaled long-acting β-adrenergic agonists (LABAs) and short-acting β-adrenergic agonists are approved for the treatment of obstructive lung disease via actions mediated by β2 adrenergic receptors (β2-ARs) that increase cellular cAMP synthesis. This review discusses the potential of β2-AR agonists, in particular LABAs, for the treatment of acute respiratory distress syndrome (ARDS). We emphasize ARDS induced by pneumonia and focus on the pathobiology of ARDS and actions of LABAs and cAMP on pulmonary and immune cell type...
Source: Pharmacological Reviews - November 19, 2021 Category: Drugs & Pharmacology Authors: Krishna Sriram Michael B Insel Paul A Insel Source Type: research

Inhaled < em > β < /em > 2 Adrenergic Agonists and Other cAMP-Elevating Agents: Therapeutics for Alveolar Injury and Acute Respiratory Disease Syndrome?
Pharmacol Rev. 2021 Oct;73(4):488-526. doi: 10.1124/pharmrev.121.000356.ABSTRACTInhaled long-acting β-adrenergic agonists (LABAs) and short-acting β-adrenergic agonists are approved for the treatment of obstructive lung disease via actions mediated by β2 adrenergic receptors (β2-ARs) that increase cellular cAMP synthesis. This review discusses the potential of β2-AR agonists, in particular LABAs, for the treatment of acute respiratory distress syndrome (ARDS). We emphasize ARDS induced by pneumonia and focus on the pathobiology of ARDS and actions of LABAs and cAMP on pulmonary and immune cell type...
Source: Pharmacological Reviews - November 19, 2021 Category: Drugs & Pharmacology Authors: Krishna Sriram Michael B Insel Paul A Insel Source Type: research

Inhaled < em > β < /em > 2 Adrenergic Agonists and Other cAMP-Elevating Agents: Therapeutics for Alveolar Injury and Acute Respiratory Disease Syndrome?
Pharmacol Rev. 2021 Oct;73(4):488-526. doi: 10.1124/pharmrev.121.000356.ABSTRACTInhaled long-acting β-adrenergic agonists (LABAs) and short-acting β-adrenergic agonists are approved for the treatment of obstructive lung disease via actions mediated by β2 adrenergic receptors (β2-ARs) that increase cellular cAMP synthesis. This review discusses the potential of β2-AR agonists, in particular LABAs, for the treatment of acute respiratory distress syndrome (ARDS). We emphasize ARDS induced by pneumonia and focus on the pathobiology of ARDS and actions of LABAs and cAMP on pulmonary and immune cell type...
Source: Pharmacological Reviews - November 19, 2021 Category: Drugs & Pharmacology Authors: Krishna Sriram Michael B Insel Paul A Insel Source Type: research

Keeping up with venetoclax for leukemic malignancies: key findings, optimal regimens and clinical considerations
Expert Rev Clin Pharmacol. 2021 Nov 18. doi: 10.1080/17512433.2021.2008239. Online ahead of print.ABSTRACTINTRODUCTION: Venetoclax has transformed the treatment landscape in hematologic malignancies, especially in elderly population. With high rates of remission, deep and durable responses, and safe toxicity profile, venetoclax in combination therapy has been extremely effective, garnering accelerated approval and becoming standard of care in lymphoid and myeloid malignancies.AREAS COVERED: The role of venetoclax in the intrinsic apoptotic pathway is covered. This includes preclinical and clinical experience of venetoclax ...
Source: Pharmacological Reviews - November 18, 2021 Category: Drugs & Pharmacology Authors: Maria Siddiqui Marina Konopleva Source Type: research

Keeping up with venetoclax for leukemic malignancies: key findings, optimal regimens and clinical considerations
Expert Rev Clin Pharmacol. 2021 Nov 18. doi: 10.1080/17512433.2021.2008239. Online ahead of print.ABSTRACTINTRODUCTION: Venetoclax has transformed the treatment landscape in hematologic malignancies, especially in elderly population. With high rates of remission, deep and durable responses, and safe toxicity profile, venetoclax in combination therapy has been extremely effective, garnering accelerated approval and becoming standard of care in lymphoid and myeloid malignancies.AREAS COVERED: The role of venetoclax in the intrinsic apoptotic pathway is covered. This includes preclinical and clinical experience of venetoclax ...
Source: Pharmacological Reviews - November 18, 2021 Category: Drugs & Pharmacology Authors: Maria Siddiqui Marina Konopleva Source Type: research

The safety profile of probiotic VSL#3 ®. A meta-analysis of safety data from double-blind, randomized, placebo-controlled clinical trials
Eur Rev Med Pharmacol Sci. 2021 Nov;25(21):6443. doi: 10.26355/eurrev_202111_27130.ABSTRACTThe article "The safety profile of probiotic VSL#3®. A meta-analysis of safety data from double-blind, randomized, placebo-controlled clinical trials", by V. Panetta, A. Bacchieri, S. Papetti, E. De Stefani, P. Navarra, published in Eur Rev Med Pharmacol Sci 2020; 24 (2): 963-973-DOI: 10.26355/eurrev_202001_20082-PMID: 32017005, has been retracted based on commentary received from a new set of reviewers. The authors will be able to resubmit a new article addressing the reviewers' comments for the Journal's consideration...
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: V Panetta A Bacchieri S Papetti E De Stefani P Navarra Source Type: research

Reduced miR-363-3p expression in non-small cell lung cancer is associated with gemcitabine resistance via targeting of CUL4A
Eur Rev Med Pharmacol Sci. 2021 Nov;25(21):6444. doi: 10.26355/eurrev_202111_27133.ABSTRACTThe article "Reduced miR-363-3p expression in non-small cell lung cancer is associated with gemcitabine resistance via targeting of CUL4A", W.-G. Bian, X.-N. Zhou, S. Song, H.-T. Chen, Y. Shen, P. Chen, published in Eur Rev Med Pharmacol Sci 2019; 23 (2): 649-659-DOI: 10.26355/eurrev_201901_16879-PMID: 30720173, has been retracted by the authors due to several inaccuracies in the research design. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/16879.PMID:34787845 | DOI:1...
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: W-G Bian X-N Zhou S Song H-T Chen Y Shen P Chen Source Type: research

Protective effect of miR-146 against kidney injury in diabetic nephropathy rats through mediating the NF- κB signaling pathway
Eur Rev Med Pharmacol Sci. 2021 Nov;25(21):6445. doi: 10.26355/eurrev_202111_27136.ABSTRACTThe article "Protective effect of miR-146 against kidney injury in diabetic nephropathy rats through mediating the NF-κB signaling pathway", H.-Y. Yu, L.-F. Meng, X.-H. Lu, L.-H. Liu, X. Ci, Z. Zhuo, published in Eur Rev Med Pharmacol Sci 2020; 24 (6): 3215-3222-DOI: 10.26355/eurrev_202003_20688-PMID: 32271439, has been retracted by the authors due to some inaccuracies (some data cannot be repeated by further research). The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/artic...
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: H-Y Yu L-F Meng X-H Lu L-H Liu X Ci Z Zhuo Source Type: research

Author Correction: Propofol inhibits invasion and enhances paclitaxel-induced apoptosis in ovarian cancer cells through the suppression of the transcription factor slug
Eur Rev Med Pharmacol Sci. 2021 Nov;25(21):6446. doi: 10.26355/eurrev_202111_27139.ABSTRACTCorrection to: European Review for Medical and Pharmacological Sciences 2013; 17 (13): 1722-1729-PMID: 23852894, published online on 15 July 2013. The authors found some mistakes in the article. • The band of β-actin in Figure 2 was an inadvertent wrong use due to an error in figure preparation. The authors confirm that the correction does not affect the discussion and conclusions of the original article. There are amendments to this paper. The Publisher apologizes for any inconvenience this may cause. https://www.europeanr...
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: P Wang J Chen L-H Mu Q-H Du X-H Niu M-Y Zhang Source Type: research

LINC00174 triggers the malignant development of breast cancer by negatively regulating miR-1827 level
CONCLUSIONS: LINC00174 is upregulated in BCa samples. It is closely linked to tumor staging, metastasis and prognosis in BCa. By negatively regulating miR-1827 level, LINC00174 aggravates the malignant development of BCa.PMID:34787848 | DOI:10.26355/eurrev_202111_27087 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: H Xu D Han K Wang T Zhang G-C Gao Source Type: research

Association between rs61764370, rs9266, and rs140080026 polymorphisms of the KRAS gene and breast cancer risk in a Mexican population
CONCLUSIONS: The rs61764370 polymorphism in the KRAS gene was associated with BC susceptibility in the Mexican population. The dominant model of the rs61764370 and rs9266 polymorphisms (classified by molecular subtype, miscarriage, TNM stage, lymph node metastasis, and Ki-67) could significantly contribute to BC risk in patients ≥50 years. The CAA haplotype could significantly contribute to BC risk in the Mexican population analyzed.PMID:34787849 | DOI:10.26355/eurrev_202111_27088 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: M P Gallegos-Arreola P M Garc ía Verdín M T Maga ña-Torres L E Figuera G M Z úñiga-González M A Rosales-Reynoso B C G ómez-Meda A M Puebla-P érez Source Type: research

Factors affecting prognosis and treatment strategies in metastatic soft tissue sarcomas: twenty years of experience
This study was a retrospective cohort study. Patients monitored with metastatic soft tissue sarcoma between January 2001 and January 2021 were evaluated retrospectively. Patients aged 18 years and over, histopathologically diagnosed with metastatic STS, and unsuitable for operations, such as local curative surgery or metastasectomy, were included in the study.RESULTS: A total of 179 patients in the metastatic stage and monitored in our center were included in the study. The median follow-up period was 8.4 months (IQR, 3.4-14.4). 58 (32.4%) patients were de-novo metastatic, and 121 (67.6%) patients developed metastasis late...
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: A İlhan E Eraslan F Yildiz Ü Y Arslan N Alki ş Source Type: research

Prognostic role of pre-operative serum ferritin level in stage 2 colon cancer
CONCLUSIONS: Serum ferritin level is an easily monitored, cost-effective, and reproducible marker. İn this study we found that high ferritin level was associated with poor survival, although it was not statistically significant.PMID:34787851 | DOI:10.26355/eurrev_202111_27091 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: H Demir I Beypinar S Urvay S E Davarc ı M Baykara Source Type: research

Bevacizumab for recurrent glioblastoma: a systematic review and meta-analysis
CONCLUSIONS: This study provides clear proof of the beneficial effects of bevacizumab treatment in recurrent GBM patients. The only observed adverse event was grade 3/4 or any grade hypertension.PMID:34787852 | DOI:10.26355/eurrev_202111_27092 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: T Zhang Q Xin J-M Kang Source Type: research

Do we really need fine-needle biopsy needle for an ultrasound-guided biopsy of pancreatic adenocarcinoma? A retrospective study
CONCLUSIONS: FNA needle (22-gauge) with adequate passes, MOSE determination and adequate processing of specimens, provided FNA and FNB specimen collection.PMID:34787853 | DOI:10.26355/eurrev_202111_27093 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: D Orlando F Gallina D Forcella F Marandino P Visca E Venti F Pierconti D Assisi Source Type: research

Diagnostic protocols in oncology: workup and treatment planning. Part 2: Abbreviated MR protocol
Eur Rev Med Pharmacol Sci. 2021 Nov;25(21):6499-6528. doi: 10.26355/eurrev_202111_27094.ABSTRACTMagnetic resonance imaging (MRI) is a non-invasive imaging technique (non-ionizing radiation) with superior soft tissue contrasts and potential morphological and functional applications. However, long examination and interpretation times, as well as higher costs, still represent barriers to MRI use in clinical routine. Abbreviated MRI protocols have emerged as an alternative to standard MRI protocols. Abbreviated MRI protocols eliminate redundant sequences that negatively affect cost, acquisition time, patient comfort. However, ...
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: V Granata G Bicchierai R Fusco D Cozzi G Grazzini G Danti F De Muzio N Maggialetti O Smorchkova M D'Elia M C Brunese R Grassi G Giacobbe F Bruno P Palumbo F Grassi L Brunese R Grassi V Miele A Barile Source Type: research

Prognostic value of the platelet-to-lymphocyte ratio for outcomes of stroke: a systematic review and meta-analysis
CONCLUSIONS: Our results indicate that PLR may not be a useful prognostic marker to predict functional outcomes after AIS. Evidence on the predictive power of PLR for mortality and END after stroke is scarce and contrasting. There is a need for further studies assessing the role of PLR in predicting outcomes of stroke patients while taking into account important confounders like baseline stroke severity and treatment modality.PMID:34787855 | DOI:10.26355/eurrev_202111_27095 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: Y-K Yan H Huang D-P Li Z-Y Ai X Li Z Sun Source Type: research

The effect of cytoplasmic dynein on the development and functional maintenance of retinal photoreceptor cells
This article summarizes the currently available knowledge relating to the effects and mechanisms of cytoplasmic dynein on the development and functional maintenance of retinal photoreceptor cells.PMID:34787856 | DOI:10.26355/eurrev_202111_27096 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: B Jia C-G Wang H Chen X-B Zhou K Qian C Chen L-X Xu J-L Fu Source Type: research

Real-world results of immune checkpoint inhibitors from the Taiwan National Health Insurance Registration System
CONCLUSIONS: Under the national registration tracking system, Taiwan's high-cost drug policy has enabled access to new medicines and maximized patient benefits.PMID:34787857 | DOI:10.26355/eurrev_202111_27097 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: S-T Hsieh H-F Ho H-Y Tai L-C Chien H-R Chang H-P Chang Y-W Huang J-J Huang H-J Lien L-Y Huang P-C Lee Source Type: research

Efficacy analysis and hemodynamic changes of hematological system diseases after PICC chemotherapy
CONCLUSIONS: The total prevalence of adverse reactions in hematological diseases by PICC infusion is lower than that by superficial vein infusion, and the catheter has no significant influence on hemodynamic indicators in patients. Therefore, PICC catheter is worthy of application and promotion in hematological diseases.PMID:34787858 | DOI:10.26355/eurrev_202111_27099 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: P Li X Sun J Tang C-S Wei J Zhao Source Type: research

Real world results of venetoclax combined with hypomethylating agents in relapsed/refractory AML
CONCLUSIONS: The study population consisted of a group of patients who had relapsed or primary refractory disease with poor prognosis, despite numerous rounds of chemotherapy. It is our belief that the high response rates obtained with the combination of venetoclax/HMA, and having obtained positive results with poor risk patients, indicated a promising perspective for R/R AML patients.PMID:34787859 | DOI:10.26355/eurrev_202111_27126 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: M A Ucar G Ozet M B Koyuncu M Sonmez O Akidan M Ayli M Yildirim M Pehlivan D M Akkurt H Sahin B Guvenc V Okan E N Tiftik A Akdeniz H D Dincyurek A K Gunes S Dagdas H I Acar H K Ucar A Tombak Source Type: research

Mitigation of doxorubicin-induced cardiotoxicity by dichloroacetate: potential roles of restoration of PGC-1 α/SIRT3 signaling and suppression of oxidative stress and apoptosis
CONCLUSIONS: The present study is the first to provide in vivo evidence that DCA is effective in protecting against acute DOX cardiotoxicity. Additionally, the study highlights the potential of administering metabolic modulators to safeguard against DOX cardiotoxicity.PMID:34787860 | DOI:10.26355/eurrev_202111_27100 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: M F Saleh M E Elsayad A E Goda Source Type: research

The efficiency of alpha-lipoic acid in the treatment of burning mouth syndrome: a systematic review
CONCLUSIONS: Some studies showed positive results of using ALA to treat the BMS, but these findings need more improvements, and more investigations are required.PMID:34787861 | DOI:10.26355/eurrev_202111_27101 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: S S Alqahtani Source Type: research

Cell-based therapies for the surgical treatment of periodontal intrabony defects: a systematic review
CONCLUSIONS: Cell-based therapies have been positively applied for the surgical treatment of intrabony periodontal defects with promising results. However, the results obtained should be interpreted with caution due to the low number of available RCTs, the study design heterogeneity, and the limited extension of the follow-up.PMID:34787862 | DOI:10.26355/eurrev_202111_27102 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: G Cecoro L Guida A Iuorio L Nucci P Pesce M Annunziata Source Type: research

Venous thromboembolism prophylaxis in plastic surgery: state of the art and our approach
CONCLUSIONS: Determining the proper venous thromboembolism prophylaxis is a clinical decision that should be made on a patient-to-patient basis. The algorithm presented in this article is meant to simplify this complex problem and to help expedite and clarify the decision-making process.PMID:34787863 | DOI:10.26355/eurrev_202111_27103 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: U Redi G Marruzzo L Codolini A Chistolini M Tarallo M Marcasciano F Lo Torto F R Grippaudo D Casella D Ribuffo Source Type: research

The role of gluten-free diet in nonalcoholic fatty liver disease development
CONCLUSIONS: Present systematic review evaluates how GFD plays a key role in NAFLD for consumption of products rich in saturated fats and carbohydrates that promotes accumulation of lipids and lead to hepatic steatosis and inflammation.PMID:34787864 | DOI:10.26355/eurrev_202111_27104 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: T Larussa L Abenavoli A C Procopio C Iannelli N Polimeni R Spagnuolo P Doldo F Luzza Source Type: research

Pediatric leiomyoma of the glans: a case report
CONCLUSIONS: We propose that leiomyoma ought to be considered in the differential diagnosis of any glans mass in children.PMID:34787865 | DOI:10.26355/eurrev_202111_27105 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: V Bagnara M Castagnetti A E Calogero R A Condorelli R Cannarella S La Vignera Source Type: research

Validity of a selective recall method for assessing water intake and its relationship with hydration status
Eur Rev Med Pharmacol Sci. 2021 Nov;25(21):6623-6632. doi: 10.26355/eurrev_202111_27106.ABSTRACTOBJECTIVE: We previously established a descriptive dietary record method that accurately quantifies habitual water intake from food and beverages, to ascertain the relationship between water intake and health. Here, we verified the validity of a selective recall method, which is easy for users to answer and analyze.PATIENTS AND METHODS: Japanese men and women aged 20-44 years (n = 16) and 45-64 years (n = 16) participated over three working days and one non-working day. The day following each of the surveyed days, participants c...
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: T Uchida Y Nakamura H Tanaka S Nakamura T Okamura H Watanabe N Murayama Source Type: research

Fetal programming of atherosclerosis: may the barker hypothesis explain the susceptibility of a subset of patients to develop stroke or cardiac infarct?
Eur Rev Med Pharmacol Sci. 2021 Nov;25(21):6633-6641. doi: 10.26355/eurrev_202111_27107.ABSTRACTThe risk stratification of young adults between subjects who will develop a mild form of atherosclerosis and subjects who will undergo a severe disease remains inaccurate. In the eighties of the previous century, David JP Barker has demonstrated the relationship between fetal conditions and occurrence of pathologies in adulthood. In this paper, the multiple evidence that might explain the increased susceptibility to severe forms of atherosclerosis, including stroke and cardiac infarct, in subjects who underwent intrauterine grow...
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: C Gerosa G Faa D Fanni G Cerrone J S Suri D Barcellona P Coni T Congiu M L Lai M Piras F Cau F Coghe A Balestrieri R Cau G Orru' A Scano P Van Eyken G La Nasa M Campagna M Castagnola Y Gibo F Marongiu L Saba Source Type: research

Logotherapy to improve parent-child relationship among mothers of autistic children: a randomized clinical trial
CONCLUSIONS: Logotherapy is an effective approach to improve the parent-child relationship in mothers of autistic children.PMID:34787868 | DOI:10.26355/eurrev_202111_27108 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: S Mihandoust M Radfar M Soleymani Source Type: research

Effect of polymorphism rs1799964 in TNF- α gene on survival in depressive patients with chronic heart failure
Eur Rev Med Pharmacol Sci. 2021 Nov;25(21):6652-6659. doi: 10.26355/eurrev_202111_27109.ABSTRACTOBJECTIVE: To date, there are no literature reports combining the relationship between depression and chronic heart failure (CHF) in relations to selective nutritional, cardiac and laboratory parameters. The aim of this study was to correlate the rs1799964 genotypes in TNF-α with clinical outcomes of depressive CHF patients.PATIENTS AND METHODS: 94 CHF patients were enrolled to assess depression prevalence and to compare values of cardiac, laboratory and nutritional parameters between depressed and non-depressed patients w...
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: G Opielak T Powr ózek A Skwarek-Dziekanowska G Sobieszek M Rahnama-Hezavah T Ma łecka-Massalska Source Type: research

Decreased serum SIRT6 as a novel predictor of coronary artery disease
In this study, we detected the expression of SIRT6 in serum by Western blotting. The concentrations of SIRT6 in serum specimens from 69 patients with CAD [30 with stable angina (SA) and 39 with acute coronary syndrome (ACS)] and 16 controls were analysed using the enzyme-linked immunosorbent assay (ELISA) method.RESULTS: Western blotting analysis of the serum samples found that SIRT6 expression was decreased in the SA group (p=0.000) and ACS group (p=0.000) compared with the control group. Significantly lower levels of serum SIRT6 were observed in SA patients (18.80±9.14 ng/mL) and ACS patients (16.85±9.66 ng...
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: Z Yan X Wang Y-S Liu X-W Xing X-G Zhang Q-H Lu Source Type: research

PM2.5-induced inflammation and myocardial cell injury in rats
Eur Rev Med Pharmacol Sci. 2021 Nov;25(21):6670-6677. doi: 10.26355/eurrev_202111_27111.ABSTRACTOBJECTIVE: Numerous studies show association of particular matter (PM) in air pollution with cardiovascular dysfunction, and increased morbidity and mortality. The main mechanisms of this adverse effect involve increasing oxidative stress, inflammatory responses, and genotoxicity. Several recent studies investigated the ability of PM2.5 to cause myocardial injury in animal models using various methods, such as intratracheal instillation, intraperitoneal injection or tail vein injection. The purpose of this study is to explore th...
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: X-N Ma R-Q Li J-L Xie S-H Li J-W Li X-X Yan Source Type: research

The association of C-reactive protein to albumin ratio with non-dipping status in hypertensive patients
Eur Rev Med Pharmacol Sci. 2021 Nov;25(21):6678-6683. doi: 10.26355/eurrev_202111_27112.ABSTRACTOBJECTIVE: A reduction of less than 10% in nocturnal blood pressure (BP) compared to daytime BP is defined as non-dipper hypertension (HT). The C-reactive protein/albumin ratio (CAR) emerged as a popular and useful biomarker for cardiovascular disease. The main purpose of this study was to examine the relationship between CAR and non-dipper status.PATIENTS AND METHODS: This was a cross-sectional study conducted between October 1, 2020 and December 1, 2020 and included 200 consecutive patients with elevated BP (102 women and 98 m...
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: L Askin H S Askin Source Type: research

Prehabilitation and heart failure: perspective in primary outcomes, a randomized controlled trial
CONCLUSIONS: Because of our preliminary results, prehabilitation program should be included among the management strategies of in elderly patients with chronic heart failure to better manage their disease and to improve their Quality of Life.PMID:34787873 | DOI:10.26355/eurrev_202111_27113 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: S Giovannini D Coraci F Di Caro L Castelli C Loreti A Chicco M Fiori A Bellieni L Gerardino C Nigito A Laudisio F Brau E D'Angelo P Caliandro L Biscotti L Padua G Zuccal à R Bernabei Source Type: research

AMP-activated protein kinase contributes to ROS-mediated p53 activation in cisplatin-induced nephrotoxicity
CONCLUSIONS: Taken together, these suggest that AMPK may be required for activation of p53 by oxidative stress in cisplatin-induced nephrotoxicity. Moreover, eIF2α phosphorylation may interrupt the AMPK-activated p53 in NRK-52E cells exposed to cisplatin, but does not critically affect cisplatin-induced nephrotoxicity because AMPK activation can be disrupted eIF2α phosphorylation.PMID:34787874 | DOI:10.26355/eurrev_202111_27114 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: S-M Ju J S Bae B-H Jeon Source Type: research

Associations of healthcare providers' awareness, perception, and knowledge of chemotherapy-induced cognitive impairment and their intentions to provide information about it to patients
This study's objective was to evaluate the power of healthcare providers' knowledge, awareness, and perception of memory impairment caused by chemotherapeutic agents, as predictors of their intentions to convey information about this side effect to patients.MATERIALS AND METHODS: A cross-sectional online survey with 32 questions and seven domains was distributed. The domains included questions about healthcare providers' behaviors, norms, attitudes, awareness, perceptions, and knowledge about chemotherapeutic agent-induced cognitive impairment and their intentions to inform patients about these side effects. Descriptive an...
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: R A Alregaibah Y S Almogbel A H Alhowail Source Type: research

Wernicke-Korsakoff syndrome in a patient with tuberculous peritonitis
Eur Rev Med Pharmacol Sci. 2021 Nov;25(21):6716-6718. doi: 10.26355/eurrev_202111_27116.ABSTRACTTuberculous peritonitis is an uncommon type of extrapulmonary tuberculosis and can be present in different and rare conditions. Wernicke-Korsakoff syndrome is a neuropsychiatric disorder due to thiamine deficiency which is caused by poor nutrition for any reason. The relationship between tuberculous peritonitis and the Wernicke-Korsakoff has not been declared yet. Therefore, we aim to report a case of tuberculous peritonitis which presented with Wernicke-Korsakoff syndrome.PMID:34787876 | DOI:10.26355/eurrev_202111_27116 (Source...
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: O Sirkeci E E Sirkeci Source Type: research

COVID-19 vaccines and vaccination program for aging adults
CONCLUSIONS: The review has mapped the COVID-19 vaccination status from the developed and developing countries for the elderly population. Finally, strategies to vaccinate all elderly adults globally against COVID-19 to enhance longevity has been suggested.PMID:34787877 | DOI:10.26355/eurrev_202111_27117 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: C Chakraborty A R Sharma M Bhattacharya G Agoramoorthy S-S Lee Source Type: research

Association between platelet indices and the severity of the disease and mortality in patients with COVID-19
CONCLUSIONS: Platelet count and ratios were significantly associated with mortality in patients with COVID-19.PMID:34787878 | DOI:10.26355/eurrev_202111_27118 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: A C Yard ımcı S Y ıldız E Ergen H Ball ı E Ergene Y S Guner M Karnap D Dem ırbas Keskın H Yuksel F Bocutoglu V C Akbel D Kalyoncu Source Type: research

In silico molecular docking studies of certain commercially available flavonoids as effective antiviral agents against spike glycoprotein of SARS-CoV-2
CONCLUSIONS: Based on the docking results, we conclude that Naringenin can be considered worthwhile to check its antiviral activity for the management of Coronavirus disease.PMID:34787879 | DOI:10.26355/eurrev_202111_27119 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: A Madeswaran S Brahmasundari P G Midhuna Source Type: research

Clearing the air about airborne transmission of SARS-CoV-2
Eur Rev Med Pharmacol Sci. 2021 Nov;25(21):6745-6766. doi: 10.26355/eurrev_202111_27120.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has created the current pandemic, has caused a worldwide worry. Different countries have since enforced varying levels of lockdowns and guidelines for their populations to follow in a serious effort to mitigate the spread. Up until recently, the majority of these regulations and policies were established on the assumption that the dominant routes of transmission of this virus are through droplets and fomite contact. However, there is now a substantial amount o...
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: R Atiyani S Mustafa S Alsari A Darwish E M Janahi Source Type: research

Mortality prediction with CHA2DS2-VASc, CHA2DS2-VASc-HS and R2CHA2DS2-VASc score in patients hospitalized due to COVID-19
CONCLUSIONS: CHA2DS2-VASc, CHA2DS2-VASc-HS, and R2CHA2DS2-VASc were found to be independent predictors of mortality in hospitalized COVID-19 patients. The current study revealed that the predictive ability of R2CHA2DS2-VASc was better than the both of CHA2DS2-VASc and CHA2DS2-VASc-HS score.PMID:34787881 | DOI:10.26355/eurrev_202111_27121 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: F Katkat S Karahan S Varol M Kalyoncuoglu E Okuyan Source Type: research

Adapting evaluation method of skills acquisition in basic cardiopulmonary resuscitation among year 5 and year 6 primary school pupils during the COVID-19 lockdown: a pilot study
CONCLUSIONS: Primary school pupils learned all the cognitive skills involved in bCPR, showing high levels of skills acquisition and positive self-perception of their capacity to apply them.PMID:34787882 | DOI:10.26355/eurrev_202111_27122 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: A C árdenas-Cruz G G ómez-Moreno A Romero-Linares D P C árdenas-Cruz A P érez-Bailón F M Parrilla-Ruiz Source Type: research

Acute severe SARS COVID-19 patients produce pro-resolving lipids mediators and eicosanoids
CONCLUSIONS: A clear disbalance favoring the pro-inflammatory axis is described, showing the need to perform future clinical interventions in these patients using SPM's or monohydroxylated lipid mediators derivates from fatty acids.PMID:34787883 | DOI:10.26355/eurrev_202111_27123 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: P-A Regidor X De La Rosa F G Santos J M Rizo R Gracia Banzo R S Silva Source Type: research

Interleukin-1 blocking agents as promising strategy for prevention of anticancer drug-induced cardiotoxicities: possible implications in cancer patients with COVID-19
Eur Rev Med Pharmacol Sci. 2021 Nov;25(21):6797-6812. doi: 10.26355/eurrev_202111_27124.ABSTRACTCytokines in cardiac tissue plays a key role in progression of cardiometabolic diseases and cardiotoxicity induced by several anticancer drugs. Interleukin-1β is one on the most studied regulator of cancer progression, survival and resistance to anticancer treatments. Recent findings indicate that interleukin1-β exacerbates myocardial damages in cancer patients treated with chemotherapies and immune check-point inhibitors. Interleukin1-β blocking agent canakinumab reduces major adverse cardiovascular events and ca...
Source: Pharmacological Reviews - November 17, 2021 Category: Drugs & Pharmacology Authors: V Quagliariello A Paccone M Iovine E Cavalcanti M Berretta C Maurea M L Canale N Maurea Source Type: research