COVID-19 Vaccination Hesitancy: A Review of the Literature and Recommendations
Curr Rev Clin Exp Pharmacol. 2022 May 12. doi: 10.2174/2772432817666220512112913. Online ahead of print.ABSTRACTVaccines are important to improve immunity against pathogens and diseases. The current COVID-19 disease is rapidly evolving and spreading among people; therefore, it is important to utilize a proper vaccination strategy against it. Currently, many approved vaccines are available and accessible; however, there is a reported hesitancy against taking them among the public and even the health care workers. Mainly, this is attributed to the fear of the possible side effects and complications. Moreover, inaccurate know...
Source: Pharmacological Reviews - May 13, 2022 Category: Drugs & Pharmacology Authors: Nasr Alrabadi Shouq Bany-Melhem Karem H Alzoubi Osama O Alzoubi Majd Masadeh Sawsan Abuhammad Sabariah Noor Harun Source Type: research

A New Family of Subnanomolar inhibitors of Soluble Epoxide Hydrolase
FASEB J. 2022 May;36 Suppl 1. doi: 10.1096/fasebj.2022.36.S1.R2281.ABSTRACTThe pharmacological inhibition of soluble epoxide hydrolase (sEH) has been suggested as a potential therapy for the treatment of pain and inflammatory diseases through the stabilization of epoxyeicosatrienoic acids, endogenous chemical mediators derived from arachidonic acid that show anti-inflammatory and analgesic effects.1 Although several potent sEH inhibitors (sEHI) have been developed, including clinical candidates AR9281, GSK2256294, and EC5026, so far no sEHI has reached the market.2 Recently, a new series of benzohomoadamantane-based ureas ...
Source: Pharmacological Reviews - May 13, 2022 Category: Drugs & Pharmacology Authors: Carmen Escolano Andrea Bagan Andreea L Turcu Christophe Morisseau M I Loza Jose Brea Clara Bartra Coral Sanfeliu Bruce D Hammock Santiago V ázquez Source Type: research

Regulation of Ncbe in the Choroid Plexus of Mice after Hemorrhage-Induced Hydrocephalus
FASEB J. 2022 May;36 Suppl 1. doi: 10.1096/fasebj.2022.36.S1.R3405.ABSTRACTThe choroid plexus (CP) is a small tissue located inside brain ventricles. It is responsible for the production of most of the cerebrospinal fluid (CSF); approximately 500 mL of CSF per day in the adult human [1, 2]. CSF production occurs as a net result of transcellular movement of salt and water, carried out by various cellular transporters. Ncbe is a sodium-coupled bicarbonate transporter located in the basolateral membrane of the choroid plexus epithelial (CPE) cells. It transports Na+ and HCO3 - into the cell in exchange for Cl- . Ncbe is the m...
Source: Pharmacological Reviews - May 13, 2022 Category: Drugs & Pharmacology Authors: Laura Ø Johnsen Kathrine A Friis Laura B Ry ø Jacob G Mikkelsen Thomas B Lindhardt Rasmus W Knopper Brian Hansen Jeppe Praetorius Helle H Damkier Source Type: research

A Candidate for Health Promotion, Disease Prevention and Treatment, Common Rue (Ruta graveolens L.), an Important Medicinal plant in Traditional Medicine
CONCLUSION: According to pharmacological and phytochemical advantages, pennyroyal shows its importance as a medicinal plant in both modern medicinal science and traditional medicine.PMID:35538827 | DOI:10.2174/2772432817666220510143902 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - May 11, 2022 Category: Drugs & Pharmacology Authors: Mohamad Hesam Shahrajabian Source Type: research

A Candidate for Health Promotion, Disease Prevention and Treatment, Common Rue (Ruta graveolens L.), an Important Medicinal plant in Traditional Medicine
CONCLUSION: According to pharmacological and phytochemical advantages, pennyroyal shows its importance as a medicinal plant in both modern medicinal science and traditional medicine.PMID:35538827 | DOI:10.2174/2772432817666220510143902 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - May 11, 2022 Category: Drugs & Pharmacology Authors: Mohamad Hesam Shahrajabian Source Type: research

A Candidate for Health Promotion, Disease Prevention and Treatment, Common Rue (Ruta graveolens L.), an Important Medicinal plant in Traditional Medicine
CONCLUSION: According to pharmacological and phytochemical advantages, pennyroyal shows its importance as a medicinal plant in both modern medicinal science and traditional medicine.PMID:35538827 | DOI:10.2174/2772432817666220510143902 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - May 11, 2022 Category: Drugs & Pharmacology Authors: Mohamad Hesam Shahrajabian Source Type: research

Published population pharmacokinetic models of valproic acid in adult patients: a systematic review and external validation in a Chinese sample of inpatients with bipolar disorder
CONCLUSION: In our validation study the most important factors contributing to good performance were absence of children, Asian ethnicity, one-compartment models and inclusion of body weight and VPA dose in previously published models.PMID:35536685 | DOI:10.1080/17512433.2022.2075849 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - May 10, 2022 Category: Drugs & Pharmacology Authors: Yan-Nan Zang Wei Guo Fang Dong An-Ning Li Jose de Leon Can-Jun Ruan Source Type: research

Givosiran for the treatment of acute hepatic porphyria
Expert Rev Clin Pharmacol. 2022 May 11:1-11. doi: 10.1080/17512433.2022.2075848. Online ahead of print.ABSTRACTINTRODUCTION: Acute hepatic porphyrias (AHPs) are a family of rare inherited disorders characterized by enzyme dysfunctions in the hepatic pathway of heme biosynthesis. In AHPs, accumulation of the neurotoxic porphyrin precursors delta-aminolevulinic acid and porphobilinogen, caused by enhanced activity of hepatic aminolevulinate synthase 1 (ALAS1), is associated with acute, potentially life-threatening neurovisceral attacks. Symptoms during and between attacks dramatically reduce patients' quality of life (QoL). ...
Source: Pharmacological Reviews - May 9, 2022 Category: Drugs & Pharmacology Authors: Andrea Ricci Paolo Ventura Source Type: research

Splicing deregulation, microRNA and Notch aberrations: fighting the three-headed dog to overcome drug resistance in malignant mesothelioma
Expert Rev Clin Pharmacol. 2022 May 9. doi: 10.1080/17512433.2022.2074835. Online ahead of print.ABSTRACTINTRODUCTION: Malignant mesothelioma (MMe) is an aggressive rare cancer of the mesothelium, associated with asbestos exposure. MMe is currently an incurable disease at all stages mainly due to resistance to treatments. It is therefore necessary to elucidate key mechanisms underlying chemoresistance, in an effort to exploit them as novel therapeutic targets.AREAS COVERED: Chemoresistance is frequently elicited by microRNA (miRNA) alterations and splicing deregulations. Indeed, several miRNAs, such as miR-29c, have been s...
Source: Pharmacological Reviews - May 9, 2022 Category: Drugs & Pharmacology Authors: Dario P Anobile Giulia Montenovo Camilla Pecoraro Marika Franczak Widad Ait Iddouch Godefridus J Peters Chiara Riganti Elisa Giovannetti Source Type: research

Givosiran for the treatment of acute hepatic porphyria
Expert Rev Clin Pharmacol. 2022 May 9. doi: 10.1080/17512433.2022.2075848. Online ahead of print.ABSTRACTINTRODUCTION: Acute hepatic porphyrias (AHPs) are a family of rare inherited disorders characterized by enzyme dysfunctions in the hepatic pathway of heme biosynthesis. In AHPs, accumulation of the neurotoxic porphyrin precursors delta-aminolevulinic acid and porphobilinogen, caused by enhanced activity of hepatic aminolevulinate synthase 1 (ALAS1), is associated with acute, potentially life-threatening neurovisceral attacks. Symptoms during and between attacks dramatically reduce patients' quality of life (QoL). Givosi...
Source: Pharmacological Reviews - May 9, 2022 Category: Drugs & Pharmacology Authors: Paolo Ventura Andrea Ricci Source Type: research

Splicing deregulation, microRNA and Notch aberrations: fighting the three-headed dog to overcome drug resistance in malignant mesothelioma
Expert Rev Clin Pharmacol. 2022 May 9. doi: 10.1080/17512433.2022.2074835. Online ahead of print.ABSTRACTINTRODUCTION: Malignant mesothelioma (MMe) is an aggressive rare cancer of the mesothelium, associated with asbestos exposure. MMe is currently an incurable disease at all stages mainly due to resistance to treatments. It is therefore necessary to elucidate key mechanisms underlying chemoresistance, in an effort to exploit them as novel therapeutic targets.AREAS COVERED: Chemoresistance is frequently elicited by microRNA (miRNA) alterations and splicing deregulations. Indeed, several miRNAs, such as miR-29c, have been s...
Source: Pharmacological Reviews - May 9, 2022 Category: Drugs & Pharmacology Authors: Dario P Anobile Giulia Montenovo Camilla Pecoraro Marika Franczak Widad Ait Iddouch Godefridus J Peters Chiara Riganti Elisa Giovannetti Source Type: research

Population pharmacokinetics of omeprazole in obese and normal-weight adults
CONCLUSION: Given the potential adverse events related to high exposure to proton pump inhibitors over time, obese patients may require a lower dose of omeprazole for long-term treatment. Further studies in obese individuals into other drugs metabolized by CYP2C19 are warranted, especially those with a narrow therapeutic window.CLINICAL TRIAL REGISTRATION: www.chictr.org.cn identifier is ChiCTR2100046578; www.chinadrugtrials.org.cn identifier is CTR20190175.PMID:35522794 | DOI:10.1080/17512433.2022.2075343 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - May 6, 2022 Category: Drugs & Pharmacology Authors: Kaifeng Chen Ping Luo Guoping Yang Shaihong Zhu Chenhui Deng Junjie Ding Yaqi Lin Liyong Zhu Qi Pei Source Type: research

Population pharmacokinetics of omeprazole in obese and normal-weight adults
CONCLUSION: Given the potential adverse events related to high exposure to proton pump inhibitors over time, obese patients may require a lower dose of omeprazole for long-term treatment. Further studies in obese individuals into other drugs metabolized by CYP2C19 are warranted, especially those with a narrow therapeutic window.CLINICAL TRIAL REGISTRATION: www.chictr.org.cn identifier is ChiCTR2100046578; www.chinadrugtrials.org.cn identifier is CTR20190175.PMID:35522794 | DOI:10.1080/17512433.2022.2075343 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - May 6, 2022 Category: Drugs & Pharmacology Authors: Kaifeng Chen Ping Luo Guoping Yang Shaihong Zhu Chenhui Deng Junjie Ding Yaqi Lin Liyong Zhu Qi Pei Source Type: research

Population pharmacokinetics of omeprazole in obese and normal-weight adults
CONCLUSION: Given the potential adverse events related to high exposure to proton pump inhibitors over time, obese patients may require a lower dose of omeprazole for long-term treatment. Further studies in obese individuals into other drugs metabolized by CYP2C19 are warranted, especially those with a narrow therapeutic window.CLINICAL TRIAL REGISTRATION: www.chictr.org.cn identifier is ChiCTR2100046578; www.chinadrugtrials.org.cn identifier is CTR20190175.PMID:35522794 | DOI:10.1080/17512433.2022.2075343 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - May 6, 2022 Category: Drugs & Pharmacology Authors: Kaifeng Chen Ping Luo Guoping Yang Shaihong Zhu Chenhui Deng Junjie Ding Yaqi Lin Liyong Zhu Qi Pei Source Type: research

Effect of probiotics on urinary tract infections in children: A systematic review and meta-analysis
CONCLUSION: Based on this systematic review and meta-analysis, probiotics could be an alternative therapy for children who are at risk of developing a UTI. They are non-pharmaceutical options and could be used as natural prophylaxis for UTIs. However, the currently published evidence does not irrefutably confirm that probiotics provide a protective effect against urinary bacterial infections. Therefore, there need to be large-scale randomized clinical trials undertaken to investigate the possible prophylaxis of probiotics.PMID:35507743 | DOI:10.2174/2772432817666220501114505 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - May 4, 2022 Category: Drugs & Pharmacology Authors: Elham Emami Catherine Mt Sherwin Saeid Heidari-Soureshjani Source Type: research