Interpreter proxy versus healthcare interpreter for administration of patient surveys following arthroplasty: a pilot study
Clinical quality registries and other systems that conduct routine post-discharge surveillance of patient outcomes following surgery may have difficulty surveying patients who have limited proficiency in the l... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - November 14, 2019 Category: Research Authors: Daniel Xue, Timothy Churches, Elizabeth Armstrong, Rajat Mittal, Justine Maree Naylor and Ian Andrew Harris Tags: Research article Source Type: research

Assessing causal treatment effect estimation when using large observational datasets
Recently, there has been a heightened interest in developing and evaluating different methods for analysing observational data. This has been driven by the increased availability of large data resources such a... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - November 14, 2019 Category: Research Authors: E. R. John, K. R. Abrams, C. E. Brightling and N. A. Sheehan Tags: Research article Source Type: research

Assessment of long-term sickness absence: content and face validity of a new questionnaire based on qualitative data from nominal groups
Increasing rates of long-term sickness absence are a worldwide problem. Belgium is the first country in Europe that aims to screen its entire population of sick leavers (sick leave> 6 weeks) for the risk of l... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - November 8, 2019 Category: Research Authors: Kaat Goorts, Charlotte Vanovenberghe, Charlotte Lambreghts, Eline Bruneel, Dorina Rusu, Sofie Vandenbroeck and Lode Godderis Tags: Research article Source Type: research

European Medicines Agency Policy 0070: an exploratory review of data utility in clinical study reports for academic research
Clinical study reports (CSRs) have been increasingly utilised within academic research in recent years. European Medicines Agency (EMA) Policy 0070 ‘Phase 1,’ which came into effect in January 2015, requires t... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - November 5, 2019 Category: Research Authors: Jean-Marc Ferran and Sarah J. Nevitt Tags: Research article Source Type: research

Definition of a systematic review used in overviews of systematic reviews, meta-epidemiological studies and textbooks
A standard or consensus definition of a systematic review does not exist. Therefore, if there is no definition about a systematic review in secondary studies that analyse them or the definition is too broad, i... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - November 4, 2019 Category: Research Authors: Marina Krnic Martinic, Dawid Pieper, Angelina Glatt and Livia Puljak Tags: Research article Source Type: research

Longitudinal inconsistency in responses to survey items that ask women about intimate partner violence
Longitudinal research has demonstrated that experiences of abuse and adversity are not consistently reported over time; however, there is a paucity of available evidence regarding the consistency of reporting ... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - October 29, 2019 Category: Research Authors: Deborah Loxton, Jennifer Powers, Natalie Townsend, Melissa L. Harris and Peta Forder Tags: Research article Source Type: research

Unweighted regression models perform better than weighted regression techniques for respondent-driven sampling data: results from a simulation study
It is unclear whether weighted or unweighted regression is preferred in the analysis of data derived from respondent driven sampling. Our objective was to evaluate the validity of various regression models, wi... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - October 29, 2019 Category: Research Authors: Lisa Avery, Nooshin Rotondi, Constance McKnight, Michelle Firestone, Janet Smylie and Michael Rotondi Tags: Research article Source Type: research

A comparison of the statistical performance of different meta-analysis models for the synthesis of subgroup effects from randomized clinical trials
When investigating subgroup effects in meta-analysis, it is unclear whether accounting in meta-regression for between-trial variation in treatment effects, but not between-trial variation in treatment interact... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - October 26, 2019 Category: Research Authors: Bruno R. da Costa and Alex J. Sutton Tags: Research article Source Type: research

Incorporating repeated measurements into prediction models in the critical care setting: a framework, systematic review and meta-analysis
The incorporation of repeated measurements into multivariable prediction research may greatly enhance predictive performance. However, the methodological possibilities vary widely and a structured overview of ... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - October 26, 2019 Category: Research Authors: Joost D. J. Plate, Rutger R. van de Leur, Luke P. H. Leenen, Falco Hietbrink, Linda M. Peelen and M. J. C. Eijkemans Tags: Research article Source Type: research

Spatiotemporal multi-disease transmission dynamic measure for emerging diseases: an application to dengue and zika integrated surveillance in Thailand
New emerging diseases are public health concerns in which policy makers have to make decisions in the presence of enormous uncertainty. This is an important challenge in terms of emergency preparation requirin... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - October 26, 2019 Category: Research Authors: Chawarat Rotejanaprasert, Andrew B. Lawson and Sopon Iamsirithaworn Tags: Research article Source Type: research

Building the skills and confidence of early childhood educators to work with parents: study protocol for the Partnering with Parents cluster randomised controlled trial
In the early years of life, the benefits of parental engagement in children ’s learning are well documented. Early childhood educators are a potentially effective source of support, having opportunity to engage... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - October 24, 2019 Category: Research Authors: Zvezdana Petrovic, Olivia Clayton, Jan Matthews, Catherine Wade, Lina Tan, Denny Meyer, Antony Gates, Alex Almendingen and Warren Cann Tags: Study protocol Source Type: research

Can a ‘consent to contact’ community help research teams overcome barriers to recruitment? The development and impact of the ‘Research for the Future’ community
Recruitment to health research remains a major challenge. Innovation is required to meet policy commitments to help patients take part in health research. One innovation that may help meet those policy goals i... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - October 22, 2019 Category: Research Authors: Katherine Grady, Martin Gibson and Peter Bower Tags: Debate Source Type: research

BUGSnet: an R package to facilitate the conduct and reporting of Bayesian network Meta-analyses
Several reviews have noted shortcomings regarding the quality and reporting of network meta-analyses (NMAs). We suspect that this issue may be partially attributable to limitations in current NMA software whic... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - October 22, 2019 Category: Research Authors: Audrey B éliveau, Devon J. Boyne, Justin Slater, Darren Brenner and Paul Arora Tags: Software Source Type: research

Sensitivity and specificity of an algorithm based on medico-administrative data to identify hospitalized patients with major bleeding presenting to an emergency department
Validation studies on an ICD-10-based algorithm to identify major bleeding events are scarce, and mostly focused on positive predictive values. (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - October 18, 2019 Category: Research Authors: Emmanuel Oger, Marie-Anne Botrel, Catherine Juchault and Jacques Bouget Tags: Research article Source Type: research

Incorporating adjustments for variability in control group response rates in network meta-analysis: a case study of biologics for rheumatoid arthritis
The importance of adjusting for cross-study heterogeneity in control group response rates when conducting network meta-analyses (NMA) was demonstrated using a case study involving a comparison of biologics for... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - October 16, 2019 Category: Research Authors: Chris Cameron, Abhishek Varu, Arthur Lau, Mahdi Gharaibeh, Marcelo Paulino and Raina Rogoza Tags: Research article Source Type: research

Acceptability and barriers to implementation of N-of-1 tests in Ethiopia - a qualitative study
Locally produced generic drugs offer a cost –effective alternative to imported drugs to treat patients in Ethiopia. However, due to a lack of bioequivalence testing, additional assurance tests are needed to bui... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - October 15, 2019 Category: Research Authors: Chalachew Alemayehu, Geoff Mitchell, Jane Nikles, Abraham Aseffa and Alexandra Clavarino Tags: Research article Source Type: research

Correction to: Feasibility of identifying important changes in care management resulting from cardiovascular magnetic resonance (CMR) using hospital episode data in patients who activate the primary percutaneous coronary intervention (PPCI) pathway
In the original publication of this article [1], the author noted two corrections after publication. (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - October 15, 2019 Category: Research Authors: Maria Pufulete, Jessica Harris, Stephen Dorman, Lynn Cook, Chiara Bucciarelli-Ducci, John P. Greenwood, Richard Anderson, Rachel Brierley and Barnaby C. Reeves Tags: Correction Source Type: research

Multi-cohort modeling strategies for scalable globally accessible prostate cancer risk tools
This report outlines a comprehensive da... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - October 15, 2019 Category: Research Authors: Johanna Tolksdorf, Michael W. Kattan, Stephen A. Boorjian, Stephen J. Freedland, Karim Saba, Cedric Poyet, Lourdes Guerrios, Amanda De Hoedt, Michael A. Liss, Robin J. Leach, Javier Hernandez, Emily Vertosick, Andrew J. Vickers and Donna P. Ankerst Tags: Research article Source Type: research

Towards a patient journey perspective on causes of unplanned readmissions using a classification framework: results of a systematic review with narrative synthesis
Several literature reviews have been published focusing on the prevalence and/or preventability of hospital readmissions. To our knowledge, none focused on the different causes which have been used to evaluate... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - October 4, 2019 Category: Research Authors: R. G. Singotani, F. Karapinar, C. Brouwers, C. Wagner and M. C. de Bruijne Tags: Research article Source Type: research

Cross-cultural adaptation of the Pain Medication Questionnaire for use in Brazil
The Pain Medication Questionnaire (PMQ) assesses the risk of opioid abuse in people with non-oncological chronic pain. (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - September 23, 2019 Category: Research Authors: Sheila Raposo Galindo, Manoel Henrique da N óbrega Marinho, Robert J. Gatchel, Tatiana de Paula Santana da Silva, Eduardo Henrique Soares Viana, Selene Cordeiro Vasconcelos and Murilo Duarte da Costa Lima Tags: Research article Source Type: research

A Bayesian non-inferiority approach using experts ’ margin elicitation – application to the monitoring of safety events
When conducing Phase-III trial, regulatory agencies and investigators might want to get reliable information about rare but serious safety outcomes during the trial. Bayesian non-inferiority approaches have be... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - September 18, 2019 Category: Research Authors: Camille Aupiais, Corinne Alberti, Thomas Schmitz, Olivier Baud, Moreno Ursino and Sarah Zohar Tags: Research Article Source Type: research

Graphical comparisons of relative disease burden across multiple risk factors
Population attributable fractions (PAF) measure the proportion of disease prevalence that would be avoided in a hypothetical population, similar to the population of interest, but where a particular risk facto... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - September 11, 2019 Category: Research Authors: John Ferguson, Neil O ’Leary, Fabrizio Maturo, Salim Yusuf and Martin O’Donnell Tags: Research article Source Type: research

A snapshot of pneumonia research activity and collaboration patterns (2001 –2015): a global bibliometric analysis
This article describes a bibliometric review of the scientific production, geographical distribution, collaboration, impact, and subject area focus of pneumonia research indexed on the Web of Science over a 15... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - September 5, 2019 Category: Research Authors: Jos é M. Ramos-Rincón, Héctor Pinargote-Celorio, Isabel Belinchón-Romero and Gregorio González-Alcaide Tags: Research article Source Type: research

Explaining differential item functioning focusing on the crucial role of external information – an example from the measurement of adolescent mental health
An overarching objective in research comparing different sample groups is to ensure that the reported differences in outcomes are not affected by differences between groups in the functioning of the measuremen... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - September 5, 2019 Category: Research Authors: Curt Hagquist Tags: Research article Source Type: research

Integrating expert opinion with clinical trial data to extrapolate long-term survival: a case study of CAR-T therapy for children and young adults with relapsed or refractory acute lymphoblastic leukemia
Long-term clinical outcomes are necessary to assess the cost-effectiveness of new treatments over a lifetime horizon. Without long-term clinical trial data, current practice to extrapolate survival beyond the ... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - September 2, 2019 Category: Research Authors: Shannon Cope, Dieter Ayers, Jie Zhang, Katharine Batt and Jeroen P. Jansen Tags: Research article Source Type: research

Statistical approaches to identify subgroups in meta-analysis of individual participant data: a simulation study
Individual participant data meta-analysis (IPD-MA) is considered the gold standard for investigating subgroup effects. Frequently used regression-based approaches to detect subgroups in IPD-MA are: meta-regres... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - September 2, 2019 Category: Research Authors: Michail Belias, Maroeska M. Rovers, Johannes B. Reitsma, Thomas P. A. Debray and Joanna IntHout Tags: Research article Source Type: research

Methods of identifying and recruiting older people at risk of social isolation and loneliness: a mixed methods review
Loneliness and social isolation are major determinants of mental wellbeing, especially among older adults. The effectiveness of interventions to address loneliness and social isolation among older adults has b... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 29, 2019 Category: Research Authors: Janet Ige, Lynn Gibbons, Issy Bray and Selena Gray Tags: Research article Source Type: research

Hierarchies of evidence applied to lifestyle Medicine (HEALM): introduction of a strength-of-evidence approach based on a methodological systematic review
The objective of this study was to characterize strength of evidence (SOE) tools in recen... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 20, 2019 Category: Research Authors: D. L. Katz, M. C. Karlsen, M. Chung, M. M. Shams-White, L. W. Green, J. Fielding, A. Saito and W. Willett Tags: Research article Source Type: research

How to measure the need for transition to adult services among young people with Attention Deficit Hyperactivity Disorder (ADHD): a comparison of surveillance versus case note review methods
Health services have not provided adequate support for young people with long term health conditions to transfer from child to adult services. National Institute of Health and Care (NICE) guidance on transitio... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 20, 2019 Category: Research Authors: Helen Eke, Astrid Janssens, Johnny Downs, Richard M. Lynn, Cornelius Ani and Tamsin Ford Tags: Research article Source Type: research

Insufficient uptake of systematic search methods in oncological clinical practice guideline: a systematic review
The objective of this study was ... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 20, 2019 Category: Research Authors: Chiara Trevisiol, Michela Cinquini, Aline S. C. Fabricio, Massimo Gion and Anne W. S. Rutjes Tags: Research article Source Type: research

Validation of diagnosis codes to identify side of colon in an electronic health record registry
The use of real-world data to generate evidence requires careful assessment and validation of critical variables before drawing clinical conclusions. Prospective clinical trial data suggest that anatomic origi... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 19, 2019 Category: Research Authors: Patricia Luhn, Deborah Kuk, Gillis Carrigan, Nathan Nussbaum, Rachael Sorg, Rebecca Rohrer, Melisa G. Tucker, Brandon Arnieri, Michael D. Taylor and Neal J. Meropol Tags: Research article Source Type: research

Pragmatic trials and implementation science: grounds for divorce?
The paper opens with a brief history of two of the major intellectual components of the recent utilitarian turn in clinical research, namely ‘pragmatic trials’ and ‘implementation science’. The two schools of tho... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 16, 2019 Category: Research Authors: Ray Pawson Tags: Debate Source Type: research

Dynamic risk prediction for diabetes using biomarker change measurements
The objective of this ... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 14, 2019 Category: Research Authors: Layla Parast, Megan Mathews and Mark W. Friedberg Tags: Research article Source Type: research

Consolidated criteria for strengthening reporting of health research involving indigenous peoples: the CONSIDER statement
Research reporting guidelines are increasingly commonplace and shown to improve the quality of published health research and health outcomes. Despite severe health inequities among Indigenous Peoples and the p... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 9, 2019 Category: Research Authors: Tania Huria, Suetonia C. Palmer, Suzanne Pitama, Lutz Beckert, Cameron Lacey, Shaun Ewen and Linda Tuhiwai Smith Tags: Research article Source Type: research

Chart validation of an algorithm for identifying hereditary progressive muscular dystrophy in healthcare claims
Muscular dystrophies (MDs) are a group of inherited conditions characterized by progressive muscle degeneration and weakness. The rarity and heterogeneity of the population with MD have hindered therapeutic de... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 9, 2019 Category: Research Authors: Xiaoxue Chen, Abiy Agiro, Ann S. Martin, Ann M. Lucas and Kevin Haynes Tags: Research article Source Type: research

High-performing physicians are more likely to participate in a research study: findings from a quality improvement study
Participants in voluntary research present a different demographic profile than those who choose not to participate, affecting the generalizability of many studies. Efforts to evaluate these differences have f... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 7, 2019 Category: Research Authors: Simone Dahrouge, Catherine Deri Armstrong, William Hogg, Jatinderpreet Singh and Clare Liddy Tags: Research article Source Type: research

Indigenous traumatic brain injury research: responding to recruitment challenges in the hospital environment
Hospitals are common recruitment sites for injury and disability studies. However, the clinical and rehabilitation environment can create unique challenges for researchers to recruit participant populations. W... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 7, 2019 Category: Research Authors: Michelle S. Fitts, Taeha Condon, John Gilroy, Katrina Bird, Erica Bleakley, Lauren Matheson, Jennifer Fleming, Alan R. Clough, Adrian Esterman, Paul Maruff and India Bohanna Tags: Research article Source Type: research

Risk of bias judgments for random sequence generation in Cochrane systematic reviews were frequently not in line with Cochrane Handbook
Assessing the risk of bias (RoB) in included studies is one of the key methodological aspects of systematic reviews. Cochrane systematic reviews appraise RoB of randomised controlled trials (RCTs) with the Coc... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 5, 2019 Category: Research Authors: Ognjen Barcot, Matija Boric, Tina Poklepovic Pericic, Marija Cavar, Svjetlana Dosenovic, Ivana Vuka and Livia Puljak Tags: Research article Source Type: research

How to analyse longitudinal data from multiple sources in qualitative health research: the pen portrait analytic technique
Longitudinal qualitative research is starting to be used in applied health research, having been popular in social research for several decades. There is potential for a large volume of complex data to be capt... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 2, 2019 Category: Research Authors: Laura Sheard and Claire Marsh Tags: Research article Source Type: research

Constructing treatment selection rules based on an estimated treatment effect function: different approaches to take stochastic uncertainty into account have a substantial effect on performance
Today we are often interested in the predictive value of a continuous marker with respect to the expected difference in outcome between a new treatment and a standard treatment. We can investigate this in a ra... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 1, 2019 Category: Research Authors: Maren Eckert and Werner Vach Tags: Research article Source Type: research

Refining scores based on patient reported outcomes – statistical and medical perspectives
Patient Reported Outcomes (PRO) are gaining more and more importance in the context of clinical trials. The assessment of PRO is frequently performed by questionnaires where the multiple items of a questionnai... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - July 31, 2019 Category: Research Authors: Manuel Fei ßt, André Hennigs, Jörg Heil, Helfried Moosbrugger, Augustin Kelava, Ilona Stolpner, Meinhard Kieser and Geraldine Rauch Tags: Research article Source Type: research

How unmeasured confounding in a competing risks setting can affect treatment effect estimates in observational studies
Analysis of competing risks is commonly achieved through a cause specific or a subdistribution framework using Cox or Fine& Gray models, respectively. The estimation of treatment effects in observational data... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - July 31, 2019 Category: Research Authors: Michael Andrew Barrowman, Niels Peek, Mark Lambie, Glen Philip Martin and Matthew Sperrin Tags: Research article Source Type: research

Using marginal standardisation to estimate relative risk without dichotomising continuous outcomes
Although criticisms regarding the dichotomisation of continuous variables are well known, applying logit model to dichotomised outcomes is the convention because the odds ratios are easily obtained and they ap... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - July 29, 2019 Category: Research Authors: Ying Chen, Yilin Ning, Shih Ling Kao, Nathalie C. St øer, Falk Müller-Riemenschneider, Kavita Venkataraman, Eric Yin Hao Khoo, E-Shyong Tai and Chuen Seng Tan Tags: Research article Source Type: research

Methodological steps used by authors of systematic reviews and meta-analyses of clinical trials: a cross-sectional study
The quality of systematic reviews and meta-analyses (SR/MAs) depends on the extent of the methods used. We investigated the methodological steps used by authors of SR/MAs of clinical trials via an author survey. (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - July 26, 2019 Category: Research Authors: Hoang Thi Nam Giang, Ali Mahmoud Ahmed, Reem Yousry Fala, Mohamed Magdy Khattab, Mona Hassan Ahmed Othman, Sara Attia Mahmoud Abdelrahman, Le Phuong Thao, Ahmed Elsaid Abd Elsamie Gabl, Samar Ahmed Elrashedy, Peter N. Lee, Kenji Hirayama, Hosni Salem and Tags: Research article Source Type: research

Using joint models to disentangle intervention effect types and baseline confounding: an application within an intervention study in prodromal Alzheimer ’s disease with Fortasyn Connect
Many prodromal Alzheimer ’s disease trials collect two types of data: the time until clinical diagnosis of dementia and longitudinal patient information. These data are often analysed separately, although they ... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - July 25, 2019 Category: Research Authors: Floor M. van Oudenhoven, Sophie H.N. Swinkels, Tobias Hartmann, Hilkka Soininen, Anneke M.J. van Hees and Dimitris Rizopoulos Tags: Research article Source Type: research

A plea for taking all available clinical information into account when assessing the predictive value of omics data
Omics data can be very informative in survival analysis and may improve the prognostic ability of classical models based on clinical risk factors for various diseases, for example breast cancer. Recent researc... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - July 24, 2019 Category: Research Authors: Alexander Volkmann, Riccardo De Bin, Willi Sauerbrei and Anne-Laure Boulesteix Tags: Research article Source Type: research

Imputation strategies when a continuous outcome is to be dichotomized for responder analysis: a simulation study
In many clinical trials continuous outcomes are dichotomized to compare proportions of patients who respond. A common and recommended approach to handling missing data in responder analysis is to impute as non... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - July 23, 2019 Category: Research Authors: Lysbeth Floden and Melanie L. Bell Tags: Research article Source Type: research

Figure Interpretation Assessment Tool-Health (FIAT-health) 2.0: from a scoring instrument to a critical appraisal tool
Statistics are frequently used in health advocacy to attract attention, but are often misinterpreted. The Figure Interpretation Assessment Tool –Health (FIAT-Health) 1.0 was developed to support systematic asse... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - July 23, 2019 Category: Research Authors: Reinie G. Gerrits, Niek S. Klazinga, Michael J. van den Berg and Dionne S. Kringos Tags: Research article Source Type: research

Patient recruitment strategies for adaptive enrichment designs with time-to-event endpoints
Adaptive enrichment designs for clinical trials have great potential for the development of targeted therapies. They enable researchers to stop the recruitment process for a certain population in mid-course ba... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - July 22, 2019 Category: Research Authors: Ryuji Uozumi, Shinjo Yada and Atsushi Kawaguchi Tags: Research article Source Type: research

Correction to: Methods to adjust for multiple comparisons in the analysis and sample size calculation of randomised controlled trials with multiple primary outcomes
In the original publication of this article [1], “=1 −  = 1 −   ≈ s” was mistakenly added after the sentence “ In this method, the unadjusted p-values pj are multiplied by the number of primary outcome” in the Me... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - July 22, 2019 Category: Research Authors: Victoria Vickerstaff, Rumana Z. Omar and Gareth Ambler Tags: Correction Source Type: research