Chemotherapy and decline of the ovarian reserve: how can we explain it and how to prevent it?
Understanding how chemotherapy affects gonadal function also allows us to understand the mechanisms protecting the pool of primordial follicles (namely, the ovarian reserve), and provides valuable insights into gonadoprotective agents that can be used to counter the adverse effects of toxic drugs. The effects of chemotherapeutic drugs on female reproduction began to be reported in the 1970s. The first accounts associated one particular alkylating agent, cyclophosphamide (CPM), with amenorrhea, premature ovarian insufficiency (POI), and ovarian dysfunction. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 18, 2020 Category: Reproduction Medicine Authors: Jacques Donnez Tags: Fertile Battle Source Type: research

Placental pathology: crucial link in the subfertility-pregnancy outcome chain
For more than 30 years, distinguishing between the effects of subfertility versus assisted reproductive technology (ART) on pregnancy outcomes has challenged the field of reproductive medicine. In the early years of in  vitro fertilization, many of the increased adverse pregnancy outcomes in ART-treated women could be attributed to the higher rate of multiple gestations. However, studies assessing ART-conceived singleton pregnancies also revealed adverse outcomes, including significantly higher rates of preterm b irth compared with those conceived naturally (1). (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 17, 2020 Category: Reproduction Medicine Authors: Caitlin R. Sacha, Mary Morris Tags: Reflections Source Type: research

Revisiting the role of serum progesterone as a test of ovulation in eumenorrheic subfertile women: a prospective diagnostic accuracy study
To estimate the prevalence of ovulatory cycles in eumenorrheic subfertile women and compare the diagnostic accuracy of a single ultrasound with serum midluteal progesterone measurement in detecting ovulatory cycles. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 15, 2020 Category: Reproduction Medicine Authors: Parimala Chinta, Grace Rebekah, Aleyamma T Kunjummen, Mohan S. Kamath Tags: Original article Source Type: research

HMGA2 involvement in uterine leiomyomas development through angiogenesis activation
Uterine leiomyoma (UL) is the most common benign estrogen-dependent tumor in women of reproductive age, affecting 25% of women and has a cumulative incidence of 70% in women by the age of 50 years because leiomyomas can be present without symptoms in most of them (1). However, 15% to 30% of women with UL present symptoms such as metrorrhagia, pelvic pain or pressure, and urinary incontinence, as well as infertility, miscarriage, and preterm birth. Leiomyomas arise from overgrowth of extracellular matrix and smooth muscle derived from myometrium, which contribute to tumor expansion (1). (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 15, 2020 Category: Reproduction Medicine Authors: Hortensia Ferrero Tags: Reflections Source Type: research

Do magnetic fields affect reproductive outcomes? Evidence against a link
Magnetic fields receive substantial attention in reproductive medicine (1). Magnetic fields are ubiquitous in the environment at low levels. However, individuals in close proximity to electromagnetic field sources may be exposed to higher amounts (2, 3). Electromagnetic fields are formed by extremely-low-frequency power sources such as electrical grids and home appliances, as well as radiofrequency telecommunication devices (2, 3). Because of the constantly increasing use of electronic devices, a growing number of researchers question whether magnetic fields may be a risk factor for adverse reproductive outcomes (1, 2). (S...
Source: Fertility and Sterility - September 15, 2020 Category: Reproduction Medicine Authors: Nathalie Auger, Shu Qin Wei, Marianne Bilodeau-Bertrand Tags: Reflections Source Type: research

Performing laparoscopic adenomyomectomy with the four-petal method
To demonstrate an innovative idea for a four-petal method for performing laparoscopic adenomyomectomy on a patient with focal-type adenomyosis. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 14, 2020 Category: Reproduction Medicine Authors: Hsin-Hong Kuo, Cindy Hsuan Weng, Amruta Jaiswal, Kai-Yun Wu, Chin-Jung Wang, Chyi-Long Lee, Chih-Feng Yen Tags: Video Source Type: research

Comparison of fertility outcomes after laparoscopic myomectomy for barbed versus nonbarbed sutures
To assess the impact on women ’s reproductive outcomes of barbed sutures to repair uterine breaches during laparoscopic myomectomy compared with traditional smooth sutures. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 12, 2020 Category: Reproduction Medicine Authors: Alessandro Arena, Eugenia Degli Esposti, Giulia Cristani, Benedetta Orsini, Elisa Moro, Diego Raimondo, Simona Del Forno, Jacopo Lenzi, Paolo Casadio, Renato Seracchioli Tags: Original article Source Type: research

Ectopic pregnancy: why do embryos get lost along the way?
Serious morbidity and mortality, thankfully, remain rare with the use of assisted reproductive technologies (1). However, when complications do arise following fertility treatments, ectopic pregnancy is rivaled perhaps only by ovarian hyperstimulation in terms of provoking anxiety in both patient and provider alike. The potential for severity is great. Rupture, if not found in a timely fashion, can have grave consequences, potentially necessitating emergency laparotomy or even resulting in death. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 10, 2020 Category: Reproduction Medicine Authors: Robert T. Rydze, Kate Schoyer, Shunping Wang Tags: Reflections Source Type: research

Neck circumference is a good predictor for insulin resistance in women with polycystic ovary syndrome
To assess the role of neck circumference (NC) in assessing insulin resistance (IR) in polycystic ovary syndrome (PCOS). (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 9, 2020 Category: Reproduction Medicine Authors: Yun Chen, Xin Zheng, Danyan Ma, Silan Zheng, Yan Han, Weijuan Su, Wei Liu, Fangsen Xiao, Mingzhu Lin, Xiaohong Yan, Tongjin Zhao, Changqin Liu Tags: Original article Source Type: research

New insights for fertility preservation by ovarian tissue cryopreservation and transplantation in pediatric cancer patients
Premature gonadal failure is a long-term health issue in young cancer patients. For these patients, ovarian tissue cryopreservation and transplantation is currently their only available option to preserve fertility. The first successful ovarian tissue transplantation resulting in a live birth occurred in 2004; significant progress has been made to increase the efficacy of this as-yet-considered experimental procedure, resulting in>130 live births globally. Nevertheless, investigations to further improve and standardize cryopreservation and transplantation technologies continue worldwide. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 9, 2020 Category: Reproduction Medicine Authors: Sonia Herraiz, Irene Cervell ó Tags: Reflections Source Type: research

Midgestation origins of androgenic and estrogenic pathophysiology in three major women ’s health disorders
David Barker first associated low birth weight with subsequent cardiovascular disease more than 30 years ago, framing mechanistic understanding of suboptimal gestational environments as major contributors to developmental origins of adult disease. Rapid-onset maternal immunologic tolerance of the semiallogeneic fetus is essential for optimal endothelial cell reprogramming within uterine spiral arteries, enabling optimal placental function. Not surprisingly, therefore, suboptimal gestational environments arise when preexisting maternal immunologic (inflammatory), metabolic, and endocrine disorders impair placental developme...
Source: Fertility and Sterility - September 9, 2020 Category: Reproduction Medicine Authors: David H. Abbott, Daniel A. Dumesic Tags: Reflections Source Type: research

Effect of levothyroxine on pregnancy outcomes in women with thyroid autoimmunity: a systematic review with meta-analysis of randomized controlled trials
To investigate whether levothyroxine is associated with improved live birth and other benefits in women with thyroid autoimmunity. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 8, 2020 Category: Reproduction Medicine Authors: Xing Wang, Yu Zhang, Huiwen Tan, Yu Bai, Liangxue Zhou, Fang Fang, Andrew Faramand, Weelic Chong, Yang Hai Tags: Original article Source Type: research

Preoperative human chorionic gonadotropin in men with Klinefelter syndrome undergoing microdissection testicular sperm extraction has prognostic value, but no therapeutic benefit
Klinefelter syndrome (KS) is the most common genetic abnormality present in infertile men, and the vast majority of nonmosaic KS patients will have nonobstructive azoospermia (NOA). Microdissection testicular sperm extraction (mTESE) is one of the most effective methods of obtaining testicular sperm, with approximately 50% of men with KS having sperm found at mTESE. Interventions that can optimize sperm retrieval rates (SRR), or at least more accurately guide preoperative counseling, would be of great value to the treatment of men with KS and NOA. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 8, 2020 Category: Reproduction Medicine Authors: Bobby B. Najari Tags: Reflections Source Type: research

Avoiding exceptionalism in reproductive endocrinology and infertility fellowship training
In 2017, responsibility for subspecialty certification in obstetrics and gynecology transitioned from the American Board of Obstetrics and Gynecology to the Accreditation Council for Graduate Medicine Education (ACGME), a private not-for-profit organization that sets standards for graduate medical education in the United States in 180 specialties and subspecialties and reviews training programs for compliance with these standards. As part of this transition, leaders in the field have been working with the ACGME to develop expectations for reproductive endocrinology and infertility (REI) fellowship training programs, deline...
Source: Fertility and Sterility - September 8, 2020 Category: Reproduction Medicine Authors: Ginny L. Ryan, Jessica D. Kresowik, Divya K. Shah Tags: Reflections Source Type: research

Molecular characteristics of varicocele: integration of whole-exome and transcriptome sequencing
To explore the exome and transcriptome characteristics potentially underlying the pathogenesis of varicocele (VE). (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 8, 2020 Category: Reproduction Medicine Authors: Bo Yang, Yuan Yang, Yunqiang Liu, Hong Li, Shangqing Ren, Zhufeng Peng, Kun Fang, Luchen Yang, Qiang Dong Tags: Original article Source Type: research

Novel and conventional embryo parameters as input data for artificial neural networks: an artificial intelligence model applied for prediction of the implantation potential
To describe novel embryo features capable of predicting implantation potential as input data for an artificial neural network (ANN) model. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 8, 2020 Category: Reproduction Medicine Authors: Lorena Bori, Elena Paya, Lucia Alegre, Thamara Alexandra Viloria, Jose Alejandro Remohi, Valery Naranjo, Marcos Meseguer Tags: Original article Source Type: research

Relugolix, an oral gonadotropin-releasing hormone receptor antagonist, reduces endometriosis-associated pain in a dose –response manner: a randomized, double-blind, placebo-controlled study
To evaluate the efficacy and safety of three dose levels of relugolix, a gonadotropin-releasing hormone receptor antagonist, compared with placebo and leuprorelin in women with endometriosis-associated pain. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 7, 2020 Category: Reproduction Medicine Authors: Yutaka Osuga, Yoshifumi Seki, Masataka Tanimoto, Takeru Kusumoto, Kentarou Kudou, Naoki Terakawa Tags: Original article Source Type: research

Intelligent light and florescence-guided surgery augmenting the surgeon ’s visual perception
One key issue that surgeons and scientists are looking to resolve is visibility beyond the surface. Another is a way to distinguish critical structures from each other. Doctors can only see so much inside the body under regular “white light,” but some are optimistic that sensory improvements can help them detect in real time what cannot be seen with the naked eye. Florescence-guided surgery is one step toward visual enhancement in surgery. A popular fluorophore today is indocyanine green (ICG), which has been used in s everal medical specialties. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 7, 2020 Category: Reproduction Medicine Authors: Ceana H. Nezhat, Tosin Odunsi Tags: Reflections Source Type: research

Fluorescence-guided management of deep endometriosis
To demonstrate the advantages of the fluorescence-guided surgery using indocyanine green (ICG) in the management of deep endometriotic nodules toward more complete and safe excision of the disease in cases when rectal shaving is performed. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 6, 2020 Category: Reproduction Medicine Authors: Atanas Aleksandrov, Moshe Meshulam, Andres Vigueras Smith, Pauline Chauvet, Michel Canis, Nicolas Bourdel Tags: Video Source Type: research

Surgical approaches of drug-free in  vitro activation and laparoscopic ovarian incision to treat patients with ovarian infertility
To demonstrate our procedures of drug-free in  vitro activation (IVA) for treating patients with premature ovarian insufficiency (POI) or diminished ovarian reserve (DOR), as well as the laparoscopic ovarian incision (LOI) procedure for treating patients with resistant ovary syndrome (ROS). (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 6, 2020 Category: Reproduction Medicine Authors: Yuka Tanaka, Aaron J. Hsueh, Kazuhiro Kawamura Tags: Video Source Type: research

Caution is warranted when discussing correlations between stress and reproductive outcomes
It is well known that infertility patients experience stress and distress (e.g., depression or anxiety symptomatology) as a result of an infertility diagnosis or infertility treatment. However, less is known about the stress levels from planned oocyte cryopreservation (OC), and comparative studies are limited. The article “Differences in perceived stress during ovarian stimulation between women with infertility or pursuing oocyte cryopreservation” is a secondary analysis of the pre- and post-treatment self-reported stress levels of 165 first-cycle in vitro fertilization (IVF) patients and 52 OC patients wh...
Source: Fertility and Sterility - September 6, 2020 Category: Reproduction Medicine Authors: Angela K. Lawson Tags: Reflections Source Type: research

Risk factors for uterine fibroids: time to build on what we have learned
Uterine leiomyomata, or fibroids, are common, and symptomatic fibroids can severely reduce quality of life (1). Current medical and surgical treatment options are expanding but are frequently transient and may conflict with fertility plans. On this background of high prevalence, high symptom burden, and treatment options with potential adverse effects, the search for modifiable exposures to reduce fibroid prevalence is important. The recent investigation by Harris et  al. (2), adds to the growing literature on the association of diet and fibroid risk. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 6, 2020 Category: Reproduction Medicine Authors: Quaker E. Harmon, Theodore M. Brasky Tags: Reflections Source Type: research

Sphingosine 1-phosphate receptors are dysregulated in endometriosis: possible implication in transforming growth factor β–induced fibrosis
To study the molecular mechanisms involved in the appearance of the fibrotic trait in endometriosis by investigating whether the signaling pathway of the bioactive sphingolipid sphingosine 1-phosphate (S1P) was altered in endometriotic lesions. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 6, 2020 Category: Reproduction Medicine Authors: Caterina Bernacchioni, Tommaso Capezzuoli, Valentina Vannuzzi, Francesca Malentacchi, Francesca Castiglione, Francesca Cencetti, Marcello Ceccaroni, Chiara Donati, Paola Bruni, Felice Petraglia Tags: Original article Source Type: research

Routine assessment of ovulation is unlikely to be medically necessary among eumenorrheic women
Because ovulation induction is generally the first-line treatment target for couples with difficulty conceiving, existing recommendations regarding the role of ovulation testing among regularly menstruating women should be clear and evidence based. The American Society for Reproductive Medicine (ASRM) recommends ovulatory function assessment as part of the female subfertility workup without specification to menstrual history regularity, and the U.K.-based National Institute for Health and Clinical Excellence (NICE) recommends midluteal progesterone testing for confirming ovulation, even among regularly menstruating women. ...
Source: Fertility and Sterility - September 6, 2020 Category: Reproduction Medicine Authors: Elizabeth A. DeVilbiss, Lindsey A. Sjaarda, Sunni L. Mumford Tags: Reflections Source Type: research

Does low-dose aspirin use impact the menstrual cycle? A hypothetical risk gets debunked
The use of daily low-dose aspirin by reproductive-age women has become increasingly common. Existing guidelines from the American College of Cardiology and the American Heart Association recommend low-dose aspirin for primary prevention of cardiovascular disease in high-risk women as young as 40 years of age (1). From a reproductive standpoint, low-dose aspirin is recommended for women at high risk for development of preeclampsia. It is also used with heparin to treat recurrent pregnancy loss in women with antiphospholipid syndrome. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 6, 2020 Category: Reproduction Medicine Authors: Jennifer L. Eaton Tags: Reflections Source Type: research

Hidden spaces: treatment of an occult uterovaginal septum
To describe the unique presentation and surgical management of a complete uterovaginal septum. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 6, 2020 Category: Reproduction Medicine Authors: John A. Occhino, Chandra C. Shenoy, Zaraq Khan Tags: Video Source Type: research

New approaches in bloom: four-petal adenomyomectomy technique
Adenomyosis is defined as ectopic endometrial glands within the myometrial layers of the uterus. Two main theories regarding the natural history of adenomyosis predominate: invagination of the endometrial basilis into the endometrial-myometrial interface secondary to repeated injury and repair, and metaplasia of displaced embryonic pluripotent m üllerian remnants (1). Adenomyosis can present as endometrial glands scattered throughout the myometrium or as a focal collection of endometrial glands, termed an adenomyoma. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 6, 2020 Category: Reproduction Medicine Authors: Matthew B. Givens, Steven R. Lindheim, Linnea R. Goodman Tags: Reflections Source Type: research

Obstetric and perinatal outcomes of intracytoplasmic sperm injection versus conventional in  vitro fertilization in couples with nonsevere male infertility
To determine whether intracytoplasmic sperm injection (ICSI) is associated with improved outcomes compared with conventional in  vitro fertilization (IVF) for patients with nonsevere male factor infertility. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 5, 2020 Category: Reproduction Medicine Authors: Lu Liu, Hongmei Wang, Zhongyuan Li, Jinlei Niu, Rong Tang Tags: Original article Source Type: research

Low-dose aspirin in reproductive health: effects on menstrual cycle characteristics
To estimate the effect of daily 81 mg low-dose aspirin (LDA) on menstrual cycle length and hormone profiles. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 5, 2020 Category: Reproduction Medicine Authors: M. Blake Evans, Carrie J. Nobles, Keewan Kim, Micah J. Hill, Alan H. DeCherney, Robert M. Silver, Sunni L. Mumford, Lindsey A. Sjaarda, Neil J. Perkins, Enrique F. Schisterman Tags: Original article Source Type: research

Activation of protein kinase B by WNT4 as a regulator of uterine leiomyoma stem cell function
To investigate the functional interaction between the Wnt/ β-catenin and protein kinase B (Akt) pathways in leiomyoma stem cells (LSC). (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 3, 2020 Category: Reproduction Medicine Authors: Shimeng Liu, Ping Yin, Ariel J. Dotts, Stacy A. Kujawa, John S. Coon V, Jian-Jun Wei, Debabrata Chakravarti, Serdar E. Bulun Tags: Original article Source Type: research

Infertility: a weight-bearing exercise?
In this issue of Fertility and Sterility, Dr. Vitek and colleagues (1) outline compelling evidence that women with polycystic ovary syndrome (PCOS) gain weight during fertility treatment. This is important because Dr. Vitek pulls her data from the Reproductive Medicine Network ’s Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation and Pregnancy in Polycystic Ovary Syndrome trials. Given the resources that fuel such trials, participants presumably have better access to reliable information, education, support, and follow-up than most women in need of fertility care. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 3, 2020 Category: Reproduction Medicine Authors: Christina E. Boots, Amelia C. Swanson, Emily S. Jungheim Tags: Reflections Source Type: research

Is Vitamin D important for IVF success?
In this issue, Dr. Cozzolino and colleagues (1) have performed a systematic review and meta-analysis on the topic of the relationship between vitamin D serum levels and in  vitro fertilization (IVF) outcomes. Their analysis determined that serum vitamin D levels have no significant effect upon IVF outcomes, as measured by clinical pregnancy rates, ongoing/live birth pregnancy rates, and/or miscarriage rates. This detailed analysis adds to the growing body of literatu re on the subject, and their conclusions are in clear contradistinction to at least one highly respected prior systematic review (2). (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 3, 2020 Category: Reproduction Medicine Authors: Peter G. McGovern Tags: Reflections Source Type: research

Examining extended human leukocyte antigen-G and HLA-F haplotypes: the HLA-G UTR-4 haplotype is associated with shorter time to pregnancy in an infertility treatment setting when both female and male partners are carriers
To study the impact of extended human leukocyte antigen (HLA)-G and HLA-F haplotypes on time to pregnancy as measured by the number of treatment cycles in a cohort of couples in infertility treatment. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2020 Category: Reproduction Medicine Authors: Line Lynge Nilsson, Thomas Scheike, C æcilie H. Langkilde, Nanna Jørgensen, Micha B. Hornstrup, Trine L. Perin, Tina Funck, Anette Lindhard, Thomas Vauvert F. Hviid Tags: Original article Source Type: research

Ovarian follicular waves during the menstrual cycle: physiologic insights into novel approaches for ovarian stimulation
Elucidation of multiple waves of antral ovarian follicular development during the menstrual cycle has challenged traditional concepts of female reproductive physiology and foundations of assisted reproductive therapies. Approximately two-thirds of women develop two follicle waves throughout an interovulatory interval and the remainder exhibit three waves of follicle development. Major and minor waves of follicle development have been observed. Major waves are those in which a dominant follicle develops; dominant follicles either regress or ovulate. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2020 Category: Reproduction Medicine Authors: Angela Baerwald, Roger Pierson Tags: Views and reviews Source Type: research

Maternal measures matter: in search of an etiology for ischemic placental disease
Over the last 40 years, the association of in  vitro fertilization (IVF) and adverse perinatal outcomes has received much attention. Increased risks of preterm delivery, low birth weight, and birth defects dominated initial concerns, often linked to high rates of IVF-associated multiple births (1). Accordingly, multiple gestations related to I VF processes were viewed as a public health emergency, and single embryo transfer was promoted to reduce adverse perinatal outcomes. With the advent of prenatal genetic testing for aneuploidy and attainment of comparable pregnancy rates with elective single embryo transfer, high...
Source: Fertility and Sterility - September 1, 2020 Category: Reproduction Medicine Authors: Esther Eisenberg Tags: Reflections Source Type: research

Science of superstimulation
Fertility clinicians and researchers are continuing to focus on achieving high rates of successful pregnancy outcomes, but there is now focus on increased rates of singleton births. In  vitro fertilization (IVF) is the most common approach for successful pregnancy outcomes, which involves manipulating and managing the complex endocrine, paracrine, and autocrine systems of embryonic and maternal origin. In vitro fertilization involves the administration of drugs to stimulate the growth of multiple follicles in the ovary, while at the same time downregulating the pituitary gland. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2020 Category: Reproduction Medicine Authors: Jaya Prakash Golla, Srujana Kola Golla, Andrew N. Shelling Tags: Reflections Source Type: research

“Online” and “at-home” versus traditional models of health care: enhancing access or impeding optimal therapeutics?
Before the advent of telehealth, prescription medication was available to patients only through a physical encounter in a hospital or clinic with a physician. Currently, in the United States, policies exist allowing the prescription of a wide range of medications after a telehealth visit (1). Our first instinct is to be skeptical of virtual efforts to treat reproductive and sexual health conditions because of our ingrained notion that a physical examination is essential in formally evaluating all medical conditions, and therefore assessing risk-benefit profiles for medications. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2020 Category: Reproduction Medicine Authors: Raul Clavijo, Ranjith Ramasamy, Joshua Halpern, Alexis Melnick, Joshua Stewart, Zev Rosenwaks, Robert Brannigan Tags: Fertile battle Source Type: research

“Online” and “at-home” versus traditional healthcare
Over the past several years, there has been an increase in direct-to-consumer marketing for both “online” and “at-home” diagnostic services and therapeutic interventions. The uptake of these new models of healthcare has been substantial, with patients reporting numerous benefits, including increased sense of privacy, ease of scheduling, flexibility, and enhanced time efficiencies. The e stablishment and rapid growth of numerous corporations that provide diagnostic and therapeutic services using such models reflects increasing patient acceptance of, and demand for, such options. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2020 Category: Reproduction Medicine Authors: Robert E. Brannigan Tags: Fertile battle Source Type: research

Expression of Concern
Badawy, et al., “Clomiphene citrate or anastrozole for ovulation induction in women with polycystic ovarian syndrome? A prospective controlled trial” (Fertil Steril 2009;92:860–63), Concern has been raised about the article listed above. The ASRM publications committee has investigated the data presented in t he study, and though separated in time and reported for different groups of study subjects, the data are identical for many of the variables in three other manuscripts (PMID:19089782; PMID:18549692; PMID:18314112). (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2020 Category: Reproduction Medicine Tags: Expression of Concern Source Type: research

Expression of Concern
Badawy, et al., “Luteal phase clomiphene citrate for ovulation induction in women with polycystic ovary syndrome: a novel protocol” (Fertil Steril 2009;91:838–41). Concern has been raised about the article listed above. The ASRM publications committee has investigated the data presented in the study, and tho ugh separated in time and reported for different groups of study subjects, the data are identical for many of the variables in two other manuscripts (PMID: 18706549 and PMID: 18166179). While a considerable time has elapsed since this manuscript was published, the similarities in data pertaining ...
Source: Fertility and Sterility - September 1, 2020 Category: Reproduction Medicine Tags: Expression of Concern Source Type: research

Expression of Concern
Badawy, et al., “Extended letrozole therapy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a novel protocol” (Fertil Steril 2009;92:236–9). Concern has been raised about the article listed above. The ASRM publications committee has investigated the data presented in the study, and though separated in time and reported for different groups of study subjects, the data are identical for many of the variables in another manuscript (PMID: 18314112). While a considerable time has elapsed since the publication of this manuscript, the similarities in data pertaining to dif f...
Source: Fertility and Sterility - September 1, 2020 Category: Reproduction Medicine Tags: Expression of Concern Source Type: research

Masthead
(Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2020 Category: Reproduction Medicine Source Type: research

Table of Contents
(Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2020 Category: Reproduction Medicine Source Type: research

RETRACTED: Letrozole versus combined metformin and clomiphene citrate for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized controlled trial
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2020 Category: Reproduction Medicine Authors: Hatem Abu Hashim, Tarek Shokeir, Ahmed Badawy Tags: Retraction notice Source Type: research

RETRACTED: Anastrozole or letrozole for ovulation induction in clomiphene-resistant women with polycystic ovarian syndrome: a prospective randomized trial
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2020 Category: Reproduction Medicine Authors: Ahmed Badawy, Abeer Mosbah, Magda Shady Tags: Retraction notice Source Type: research

RETRACTED: Clomiphene citrate or letrozole for ovulation induction in women with polycystic ovarian syndrome: a prospective randomized trial
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2020 Category: Reproduction Medicine Authors: Ahmed Badawy, Ibrahim Abdel Aal, Mohamed Abulatta Tags: Retraction notice Source Type: research

RETRACTED: Clomiphene citrate or aromatase inhibitors for superovulation in women with unexplained infertility undergoing intrauterine insemination: a prospective randomized trial
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2020 Category: Reproduction Medicine Authors: Ahmed Badawy, Abubaker Elnashar, Mohamed Totongy Tags: Retraction notice Source Type: research

Embryo transfer training in fellowship: national and institutional data
To evaluate current national practices in embryo transfer (ET) training in United States reproductive endocrinology and infertility (REI) fellowship programs and live birth rates after ET performed by fellows versus attending physicians. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2020 Category: Reproduction Medicine Authors: Dana B. McQueen, Jared C. Robins, Chen Yeh, John X. Zhang, Eve C. Feinberg Tags: Original article Source Type: research

A Four Step Strategy for Robot Assisted Abdominal Cerclage Placement Prior to Pregnancy
To demonstrate a simple, stepwise strategy for robot-assisted abdominal cerclage placement before pregnancy. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2020 Category: Reproduction Medicine Authors: Allison L. Heiden, Payam Katebi Kashi, G. Scott Rose, Katherine L. Dengler Tags: Video Source Type: research

Faster fertilization and cleavage kinetics reflect competence to achieve a live birth after intracytoplasmic sperm injection, but this association fades with maternal age
To assess the relationship of early developmental kinetics with competence to provide a live birth and the impact of maternal age in this context. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2020 Category: Reproduction Medicine Authors: Mariabeatrice Dal Canto, Alessandro Bartolacci, Diana Turchi, Daniela Pignataro, Monia Lain, Elena De Ponti, Claudio Brigante, Mario Mignini Renzini, Jose Buratini Tags: Original article Source Type: research