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Are cleavage anomalies, multinucleation, or specific cell cycle kinetics observed with time-lapse imaging predictive of embryo developmental capacity or ploidy?
To determine whether cleavage anomalies, multinucleation, and specific cellular kinetic parameters available from time-lapse imaging are predictive of developmental capacity or blastocyst chromosomal status. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 13, 2018 Category: Reproduction Medicine Authors: Nina Desai, Jeffrey M. Goldberg, Cynthia Austin, Tommaso Falcone Tags: Original article Source Type: research

Cumulus cell transcriptome profiling is not predictive of live birth after in  vitro fertilization: a paired analysis of euploid sibling blastocysts
To compare the transcriptome of cumulus cells associated with a euploid embryo that resulted in live birth with that of a sibling euploid embryo without sustained implantation. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 7, 2018 Category: Reproduction Medicine Authors: Katherine A. Green, Jason M. Franasiak, Marie D. Werner, Xin Tao, Jessica N. Landis, Richard T. Scott, Nathan R. Treff Tags: Original article Source Type: research

Mycoplasma genitalium can modulate the local immune response in patients with endometriosis
To detect Mollicutes in women with endometriosis and healthy peritoneal tissues and evaluate the participation of these bacteria in the immune response during endometriosis. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 7, 2018 Category: Reproduction Medicine Authors: Guilherme B. Campos, Lucas M. Marques, Izadora S. Rezende, Maysa S. Barbosa, Mauricio S. Abr ão, Jorge Timenetsky Tags: Original article Source Type: research

Gestational carrier in assisted reproductive technology
To compare clinical outcomes of in  vitro fertilization (IVF) cycles with the use of gestational carriers (GCs) with non-GC IVF cycles. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 7, 2018 Category: Reproduction Medicine Authors: Gayathree Murugappan, Leslie V. Farland, Stacey A. Missmer, Katharine F. Correia, Raymond M. Anchan, Elizabeth S. Ginsburg Tags: Original article Source Type: research

Differential rate in decline in ovarian reserve markers in women with polycystic ovary syndrome compared with control subjects: results of a longitudinal study
To estimate rates of ovarian aging in polycystic ovary syndrome (PCOS) subjects versus a community control population. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 7, 2018 Category: Reproduction Medicine Authors: Asima K. Ahmad, Chia-Ning Kao, Molly Quinn, Nikolaus Lenhart, Mitchell Rosen, Marcelle I. Cedars, Heather Huddleston Tags: Original article Source Type: research

Association of testosterone and antim üllerian hormone with time to pregnancy and pregnancy loss in fecund women attempting pregnancy
To examine whether higher T and/or antim üllerian hormone (AMH) was associated with anovulation, time to pregnancy (TTP), or pregnancy loss risk among healthy, fecund women without diagnosed polycystic ovary syndrome. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 7, 2018 Category: Reproduction Medicine Authors: Lindsey A. Sjaarda, Sunni L. Mumford, Daniel L. Kuhr, Tiffany L. Holland, Robert M. Silver, Torie C. Plowden, Neil J. Perkins, Enrique F. Schisterman Tags: Original article Source Type: research

Impact of cancer treatment on risk of infertility and diminished ovarian reserve in women with polycystic ovary syndrome
To compare markers of fertility and ovarian reserve between cancer survivors and cancer-free women with and without polycystic ovary syndrome (PCOS). (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 7, 2018 Category: Reproduction Medicine Authors: Lisa M. Shandley, Amy Fothergill, Jessica B. Spencer, Ann C. Mertens, Hanh N. Cottrell, Penelope P. Howards Tags: Original article Source Type: research

Reproductive and metabolic determinants of granulosa cell dysfunction in normal-weight women with polycystic ovary syndrome
To determine the degree to which E2 hyperresponsiveness to FSH and antim üllerian hormone (AMH) overproduction in normal-weight women with polycystic ovary syndrome (PCOS) correlate with increased antral follicle number (AFN), hyperandrogenism, and/or metabolic dysfunction. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 7, 2018 Category: Reproduction Medicine Authors: Annie A. Guedikian, Alexandria Y. Lee, Tristan R. Grogan, David H. Abbott, Karla Largaespada, Gregorio D. Chazenbalk, Daniel A. Dumesic Tags: Original article Source Type: research

Oocyte vitrification versus ovarian cortex transplantation in fertility preservation for adult women undergoing gonadotoxic treatments: a prospective cohort study
To compare the efficacy of oocyte vitrification (OV) with that of ovarian cortex cryopreservation and transplantation (OCT) in women undergoing gonadotoxic treatments. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 7, 2018 Category: Reproduction Medicine Authors: Cesar Diaz-Garcia, Javier Domingo, Juan Antonio Garcia-Velasco, Sonia Herraiz, Vicente Mirabet, Ignacio Iniesta, Ana Cobo, Jos é Remohí, Antonio Pellicer Tags: Original article Source Type: research

High-molecular-weight adiponectin is inversely associated with sympathetic activity in polycystic ovary syndrome
To examine the role of high-molecular-weight (HMW) adiponectin and its relationship to sympathetic activity in women with polycystic ovary syndrome (PCOS). (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 7, 2018 Category: Reproduction Medicine Authors: Soulmaz Shorakae, Sally K. Abell, Danielle S. Hiam, Elisabeth A. Lambert, Nina Eikelis, Eveline Jona, Carolina Ika Sari, Nigel K. Stepto, Gavin W. Lambert, Barbora de Courten, Helena J. Teede Tags: Original article Source Type: research

Clinical outcomes in carriers of complex chromosomal rearrangements: a retrospective analysis of comprehensive chromosome screening results in seven cases
To evaluate the clinical outcomes in carriers of complex chromosomal rearrangements (CCRs). (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 7, 2018 Category: Reproduction Medicine Authors: Liang Hu, Yajing Wei, Keli Luo, Pingyuan Xie, Fei Gong, Bo Xiong, Yueqiu Tan, Guangxiu Lu, Ge Lin Tags: Original article Source Type: research

Assessing access to assisted reproductive services for serodiscordant couples with human immunodeficiency virus infection
To understand the barriers that serodiscordant couples with human immunodeficiency virus (HIV) face in accessing services for risk reduction and infertility using assisted reproductive technology (ART). (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 7, 2018 Category: Reproduction Medicine Authors: Ashley A. Leech, Pietro Bortoletto, Cindy Christiansen, Mari-Lynn Drainoni, Benjamin P. Linas, Cassandra Roeca, Megan Curtis, Meg Sullivan Tags: Original article Source Type: research

Dehydroepiandrosterone enhances decidualization in women of advanced reproductive age
To investigate the impact of the androgen precursor dehydroepiandrosterone (DHEA) on the decidualization of human endometrial stromal cells isolated from women of advanced reproductive age. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 3, 2018 Category: Reproduction Medicine Authors: Douglas A. Gibson, Ioannis Simitsidellis, Olympia Kelepouri, Hilary O.D. Critchley, Philippa T.K. Saunders Tags: Original article Source Type: research

Robotic-assisted surgery in live-donor uterus transplantation
The video by Fornalik and Fornalik on robotic-assisted uterus transplantation (1) is of interest in the developing field of uterus transplantation (UTx). It relates to infertility treatment of women with absolute uterine factor infertility, with either uterine absence (congenital/surgical) or abnormalities (anatomic/functional) that impede implantation of an embryo or completion of a pregnancy. This condition has been untreatable until recently; in our report of a birth occurring in 2014 (2), UTx proved to be an effective treatment. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 3, 2018 Category: Reproduction Medicine Authors: Mats Br ännström, Pernilla Dahm-Kähler, Niclas Kvarnström Tags: Reflections Source Type: research

Exome and genome sequencing in reproductive medicine
The advent of next-generation sequencing has enabled clinicians to assess many genes simultaneously and at high resolution. This is advantageous for diagnosing patients in whom a genetic disorder is suspected but who have a nonspecific or atypical phenotype or when the disorder has significant genetic heterogeneity. Herein, we describe common clinical applications of next-generation sequencing technology, as well as their respective benefits and limitations. We then discuss key considerations of variant interpretation and reporting, clinical utility, pre- and posttest genetic counseling, and ethical challenges. (Source: Fe...
Source: Fertility and Sterility - February 3, 2018 Category: Reproduction Medicine Authors: Elizabeth A. Normand, Joseph T. Alaimo, Ignatia B. Van den Veyver Tags: Views and reviews Source Type: research

Nature versus science, transferring embryos or blame
In 1785, as legend has it, the Scottish poet Robert Burns was plowing his field when he overturned the nest of a field mouse, leaving it without shelter against the approaching winter. He composed a poem on the spot to lament the illusion of control we all possess when it comes to Mother Nature:But mouse-friend, you are not alonein proving foresight may be vain:the best-laid schemes of Mice and Mengo oft awry,and leave us only grief and pain,for promised joy!(from To a Mouse, trans. M.R. Burch) (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 3, 2018 Category: Reproduction Medicine Authors: Neil Ryan Chappell, William E. Gibbons Tags: Reflections Source Type: research

Expanded carrier screening: what the reproductive endocrinologist needs to know
Expanded carrier screening refers to identification of carriers of single-gene disorders outside of traditional screening guidelines. New genetic testing technologies allow for such screening at costs that are comparable to single-gene testing. There is a high degree of variability among genetic testing laboratories as to the inclusion of different disorders, some of which have mild or unpredictable phenotypes. This review discusses the pros and cons of using expanded carrier screening in the preconceptional patient and reviews guidelines currently endorsed by professional organizations. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 1, 2018 Category: Reproduction Medicine Authors: Jeffrey Dungan Tags: Views and reviews Source Type: research

Ethical quandaries around expanded carrier screening in third-party reproduction
Although current screening methods of gamete donors are capable of reducing the incidence of genetic anomalies in donor offspring below general population levels, targeted screening for a large number of conditions (expanded carrier screening or ECS) could be considered as part of the routine selection procedure for gamete donors. There are, however, important drawbacks to its practical implementation. Excluding all carriers of severe recessive monogenic pediatric disorders would disqualify virtually all donors, and other approaches negatively affect cost (and therefore access), present dilemmas in regard to disclosure of ...
Source: Fertility and Sterility - February 1, 2018 Category: Reproduction Medicine Authors: Heidi Mertes, Steven R. Lindheim, Guido Pennings Tags: Views and reviews Source Type: research

Prevention of in  vitro fertilization twins should focus on maximizing single embryo transfer versus twins are an acceptable complication of in vitro fertilization
Twin pregnancy is an iatrogenic complication of in  vitro fertilization (IVF) associated with severe as well as subtle adverse outcomes (1). With higher implantation rates (IRs) and refined cryopreservation protocols for extra embryos (2), many centers like ours worldwide have made single embryo transfer (SET) the default choice for most IVF couple s. When accompanied by preimplantation genetic screening, elective SET (eSET) pregnancy rates at all ages have reached 50% or higher (3), whereas double embryo transfer (DET) would carry an unacceptable risk of twins. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 1, 2018 Category: Reproduction Medicine Authors: David R. Meldrum, Eli Y. Adashi, V. Gabriel Garzo, Norbert Gleicher, Jean Parinaud, Anja Pinborg, Brad Van Voorhis Tags: Fertile battle Source Type: research

Cell-free DNA for the detection of fetal aneuploidy
Screening for fetal aneuploidy via cell-free DNA was described more than two decades ago and has been used clinically by obstetric providers in the United States for more than 5  years. Cell-free DNA affords excellent detection of fetal Down syndrome and other common aneuploidies and thus is sought by patients and providers. However, owing to the source of the DNA and the nature of the screening test, scenarios may arise that require expert counseling about complex issues regarding fetal and maternal health, test interpretation, and management. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 1, 2018 Category: Reproduction Medicine Authors: Tamar Goldwaser, Susan Klugman Tags: Views and reviews Source Type: research

Prenatal diagnosis by chromosomal microarray analysis
Chromosomal microarray analysis (CMA) is performed either by array comparative genomic hybridization or by using a single nucleotide polymorphism array. In the prenatal setting, CMA is on par with traditional karyotyping for detection of major chromosomal imbalances such as aneuploidy and unbalanced rearrangements. CMA offers additional diagnostic benefits by revealing sub-microscopic imbalances or copy number variations that are too small to be seen on a standard G-banded chromosome preparation. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 1, 2018 Category: Reproduction Medicine Authors: Brynn Levy, Ronald Wapner Tags: Views and reviews Source Type: research

Editorial Board
(Source: Fertility and Sterility)
Source: Fertility and Sterility - February 1, 2018 Category: Reproduction Medicine Source Type: research

Table of Contents
(Source: Fertility and Sterility)
Source: Fertility and Sterility - February 1, 2018 Category: Reproduction Medicine Source Type: research

Parental health status and infant outcomes: Upstate KIDS Study
To assess parental health status inclusive of infertility and infant outcomes. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 15, 2018 Category: Reproduction Medicine Authors: Germaine M. Buck Louis, Erin Bell, Yunlong Xie, Rajeshwari Sundaram, Edwina Yeung Tags: Original article Source Type: research

Obstetric complications after frozen versus fresh embryo transfer in women with polycystic ovary syndrome: results from a randomized trial
To evaluate the effect of frozen embryo transfer on maternal and neonatal complications of singleton and twin pregnancies compared with fresh embryo transfer in women with polycystic ovary syndrome (PCOS). (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 15, 2018 Category: Reproduction Medicine Authors: Bo Zhang, Daimin Wei, Richard S. Legro, Yuhua Shi, Jing Li, Lin Zhang, Yan Hong, Gang Sun, Ting Zhang, Weiping Li, Zi-Jiang Chen Tags: Original article Source Type: research

Long-term outcomes in cancer patients who did or did not pursue fertility preservation
To compare long-term outcomes of cancer patients who pursued fertility preservation (FP) with those who did not and compare random-start (RS) and menstrual cycle –specific (CS) protocols for FP. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 15, 2018 Category: Reproduction Medicine Authors: Molly B. Moravek, Rafael Confino, Kristin N. Smith, Ralph R. Kazer, Susan C. Klock, Angela K. Lawson, William J. Gradishar, Mary Ellen Pavone Tags: Original article Source Type: research

Vitrified blastocyst transfer cycles with the use of only vaginal progesterone replacement with Endometrin have inferior ongoing pregnancy rates: results from the planned interim analysis of a three-arm randomized controlled noninferiority trial
To assess the noninferiority of vaginal P (Endometrin) compared with daily intramuscular P for replacement in programmed vitrified-warmed blastocyst transfer cycles and to assess the noninferiority of vaginal P in combination with intramuscular progesterone every third day compared with daily intramuscular P. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 15, 2018 Category: Reproduction Medicine Authors: Kate Devine, Kevin S. Richter, Eric A. Widra, Jeffrey L. McKeeby Tags: Original article Source Type: research

A new predictive parameter for embryo transfer success: a path forward is needed to implement it in technique training
Success rates in assisted reproduction have enjoyed a steady rise in the past several decades. Much of this success can be attributed to the progressive improvements in embryology laboratory techniques and embryo selection, including extended embryo culture and preimplantation genetic screening among other techniques. However, it is clear that clinical techniques related to ovarian stimulation and oocyte retrieval, which influence the number and quality of gametes, and the embryo transfer procedure, which replaces those carefully cultured and selected embryos, play important roles. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 11, 2018 Category: Reproduction Medicine Authors: Jason Franasiak Tags: Reflections Source Type: research

Metabolic syndrome, hypertension, and hyperlipidemia in mothers, fathers, sisters, and brothers of women with polycystic ovary syndrome: a systematic review and meta-analysis
To provide an evidence-based assessment of metabolic syndrome, hypertension, and hyperlipidemia in first-degree relatives of women with polycystic ovary syndrome (PCOS). (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 11, 2018 Category: Reproduction Medicine Authors: Bulent Yilmaz, Priyathama Vellanki, Baris Ata, Bulent Okan Yildiz Tags: Original article Source Type: research

Pregnancy-related complications and perinatal outcomes resulting from transfer of cryopreserved versus fresh embryos in  vitro fertilization: a meta-analysis
To provide an updated comparison of pregnancy-related complications and adverse perinatal outcomes of pregnancies conceived after frozen embryo transfer (FET) versus fresh embryo transfer (fresh ET). (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 11, 2018 Category: Reproduction Medicine Authors: Tingting Sha, Xunqiang Yin, Wenwei Cheng, Isaac Yaw Massey Tags: Original article Source Type: research

Antim üllerian hormone as a predictor of live birth following assisted reproduction: an analysis of 85,062 fresh and thawed cycles from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database for 2012–2013
To determine if serum antim üllerian hormone (AMH) is associated with and/or predictive of live birth assisted reproductive technology (ART) outcomes. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 11, 2018 Category: Reproduction Medicine Authors: Reshef Tal, David B. Seifer, Ethan Wantman, Valerie Baker, Oded Tal Tags: Original article Source Type: research

Time-lapse algorithms and morphological selection of day-5 embryos for transfer: a preclinical validation study
To determine the agreement between published time-lapse algorithms in selecting the best day-5 embryo for transfer, as well as the agreement between these algorithms and embryologists. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 11, 2018 Category: Reproduction Medicine Authors: Ashleigh Storr, Christos Venetis, Simon Cooke, Suha Kilani, William Ledger Tags: Original article Source Type: research

In vitro fertilization twins: acceptable when desired, or iatrogenic complication preventable through elective single embryo transfer?
An obstetrician recently shared her emotionally draining experience managing live delivery of in  vitro fertilization (IVF) twins at 20 weeks gestation (1). Over my 35 years in IVF I have heard of many pre-viable losses of IVF twins. Her wrenching account should be required reading for any IVF provider who allows transfer of two embryos outside of Society for Assisted Reproductive Technology (SART) guidelines. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 11, 2018 Category: Reproduction Medicine Authors: David R. Meldrum Tags: Fertile battle: introduction Source Type: research

Sperm donor anonymity: a  concept rendered obsolete by modern technology
The use of donor sperm began as a medical practice with a level of secrecy bordering on shame. In the United States, donor sperm insemination was first performed by Dr. William Pancoast in 1884 at Thomas Jefferson Medical College in Philadelphia. The patient was never told, and it is unclear whether the husband was completely informed as to exactly what was occurring. This was done to prevent “irreparable harm” to the resultant child and the marriage. The case was not published until 1909, 25 years later. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 11, 2018 Category: Reproduction Medicine Authors: Peter G. McGovern, William D. Schlaff Tags: Inklings Source Type: research

A new predictive parameter for embryo transfer success, but a path forward is needed to implement it in technique training path forward needed to implement in technique training
Success rates in assisted reproduction have enjoyed a steady rise in the past several decades. Much of this success can be attributed to the progressive improvements in embryology laboratory techniques and embryo selection, including extended embryo culture and preimplantation genetic screening among other techniques. However, it is clear that clinical techniques related to ovarian stimulation and oocyte retrieval, which influence the number and quality of gametes, and the embryo transfer procedure, which replaces those carefully cultured and selected embryos, play important roles. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 11, 2018 Category: Reproduction Medicine Authors: Jason Franasiak Tags: Reflections Source Type: research

Erratum
In the article by Karavani et  al., “Transvaginal ultrasound to guide embryo transfer: a randomized controlled trial” (Fertil Steril 2017;107:1159-1165), two of the authors’ affiliations are listed incorrectly. Dr. Ariel Revel’s correct affiliation is Department of Obstetrics and Gynecology, Hadassah Hebrew University H ospital, Jerusalem, Israel. Dr. Yoel Shufaro’s correct affiliation is Infertility and IVF Unit, Beilinson Hospital, Rabin Medical Center, Petach-Tikva 49100 and the Sackler Faculty of Medicine, Tel-Aviv University, Israel. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 10, 2018 Category: Reproduction Medicine Tags: Erratum Source Type: research

Erratum
The article by Arendt et  al., “Maternal endometriosis and genital malformations in boys: a Danish register-based study” (Fertil Steril 2017;108:687–693), contains the following errors in the confidence intervals reported from the subanalysis stratified by medically assisted reproduction (MAR). (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 10, 2018 Category: Reproduction Medicine Tags: Erratum Source Type: research

C-Reactive protein in relation to fecundability and anovulation among eumenorrheic women
To assess systemic inflammation in relation to fecundability and anovulation. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 6, 2018 Category: Reproduction Medicine Authors: Rose G. Radin, Lindsey A. Sjaarda, Robert M. Silver, Carrie J. Nobles, Sunni L. Mumford, Neil J. Perkins, Brian D. Wilcox, Anna Z. Pollack, Karen C. Schliep, Torie C. Plowden, Enrique F. Schisterman Tags: Original article Source Type: research

Low dosing of gonadotropins in in  vitro fertilization cycles for women with poor ovarian reserve: systematic review and meta-analysis
To evaluate the effectiveness of low doses of gonadotropins and gonadotropins combined with oral compounds compared with high doses of gonadotropins in ovarian stimulation regimens in terms of ongoing pregnancy per fresh IVF attempt in women with poor ovarian reserve undergoing IVF/intracytoplasmic sperm injection (ICSI) treatment. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 6, 2018 Category: Reproduction Medicine Authors: Mohamed Abdel-Fattah Youssef, Madelon van Wely, Monique Mochtar, Usama Mohamed Fouda, Ashraf Eldaly, Eman Zein El Abidin, Ahmed Elhalwagy, Ahmed Abdel Mageed Abdallah, Sherif Sameh Zaki, Mohamed Sayed Abdel Ghafar, Mohamed Nagi Mohesen, Fulco van der Veen Tags: Original article Source Type: research

Navigating the complex challenges of fertility preservation
As oncology treatment continues to improve, long-term survival is now the expectation for many reproductive-age patients who receive a cancer diagnosis. With this progress comes the hope for future fertility, making discussion of the option of fertility preservation (FP) an essential component to the cancer diagnosis and treatment process. Unfortunately, FP counseling, access, and utilization can vary widely at different medical centers and greatly impact cancer patients' experiences. In this issue of Fertility and Sterility, Moravek et  al. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 6, 2018 Category: Reproduction Medicine Authors: Lisa C. Grossman Becht, Eric J. Forman Tags: Reflections Source Type: research

What do we know about the relationships between preconception parental health, infertility, and pregnancy outcomes?
Until recently, research on parental health in humans has focused largely on associations with fertility measures and pregnancy. With the exception of maternal diabetes mellitus and obesity, those studies that extend to infant outcomes most commonly involved maternal exposures to environmental or pharmaceutical toxins. The effects of paternal exposures and health on infant outcomes are much less studied than maternal effects. Work in experimental and domestic species has demonstrated that preconception parental health can affect pregnancy outcomes and offspring characteristics, even across multiple generations. (Source: Fe...
Source: Fertility and Sterility - January 6, 2018 Category: Reproduction Medicine Authors: Erma Z. Drobnis, Danny J. Schust Tags: Reflections Source Type: research

Family Ties
Who doesn't remember de sitcom Family Ties broadcasted by NBC for seven seasons, starting in 1982 and concluding in 1989. The series dealt with a typical U.S. phenomenon---the move from the cultural liberalism of the 1960s and 1970s to the conservatism of the 1980s. This was particularly expressed through the relationship between young Republican Alex P. Keaton, portrayed by Michael J. Fox, and his ex-hippie parents, Steven and Elyse Keaton, portrayed by Michael Gross and Meredith Baxter. Much of the humor of the series focuses on the cultural divide during the 1980s when younger generations rejected the typical hippie cul...
Source: Fertility and Sterility - January 6, 2018 Category: Reproduction Medicine Authors: Joop S.E. Laven Tags: Reflections Source Type: research

Intergenerational gamete donation may be clinically challenging, but it is ethically defensible
The web-based survey of attitudes regarding intergenerational gamete donation conducted by Bortoletto et  al. (1) from Brigham and Women's Hospital supports the premise that the American public is generally supportive of the practice, at least as it relates to women. Although the study design was somewhat flawed, since sampling was conducted exclusively within an income bracket of middle class and abo ve individuals who access the internet and were incentivized to participate, the results clearly demonstrated that the majority of respondents did not object to the concept of sharing eggs between mothers and daughters, ...
Source: Fertility and Sterility - January 6, 2018 Category: Reproduction Medicine Authors: Mark V. Sauer Tags: Reflections Source Type: research

Deciphering the complex relationship between systemic inflammation and fecundity in eumenorrheic women
To date, the general belief is that some degree of systemic or uterine inflammation is essential for normal function of the ovary, uterus, embryo, implantation, and pregnancy (1). However, it is also believed that when inflammation becomes too excessive or chronic, degradation of the embryo and impaired implantation could result. In this issue of Fertility and Sterility, Radin and colleagues investigated the relationship of high-sensitivity C-reactive protein (hs-CRP), a marker of chronic low-grade inflammation, to fecundability and anovulation in healthy, regularly menstruating women (2). (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 6, 2018 Category: Reproduction Medicine Authors: Audrey J. Gaskins Tags: Reflections Source Type: research

Optimizing luteal support in frozen embryo transfer cycles
There is a paucity of high-quality literature on luteal support in frozen embryo transfer cycles, and there is no consensus regarding the optimal formulation, route, dosage, or duration of progesterone. A Cochrane review in 2010 (1) concluded that “there is insufficient evidence to recommend any one particular protocol.” A more recent meta-analysis (2) drew similar conclusions. Optimizing frozen embryo transfer cycles is of utmost importance, as the number of assisted reproductive technology (ART) cycles performed for banking embryos and oocytes has increased more than 10-fold over the past 10 years (3). (...
Source: Fertility and Sterility - January 6, 2018 Category: Reproduction Medicine Authors: Thomas L. Toth, Denis A. Vaughan Tags: Reflections Source Type: research

Introduction
Genomic based technologies are firmly implanted into clinical medicine. They arrived rapidly and their uses continue to evolve in both the pre and postconception periods. These technologies migrated from the prenatal arena into the domain of the reproductive endocrinology and infertility specialists in some cases nearly simultaneously (expanded carrier screening), in others more slowly (chromosome microarrays), and for some technologies the ethical and cost concerns have resulted in a slower diffusion across the disciplines. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 6, 2018 Category: Reproduction Medicine Authors: Anthony R. Gregg, Steven R. Lindheim Tags: Views and reviews Source Type: research

Effect of air bubbles localization and  migration after embryo transfer on assisted reproductive technology outcome
To evaluate the effect of embryo flash position and movement of the air bubbles at 1 and 60  minutes after ET on clinical pregnancy rates (PRs). (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 4, 2018 Category: Reproduction Medicine Authors: Cem F ıçıcıoğlu, Pınar Özcan, Melis G. Koçer, Mert Yeşiladalı, Oya Alagöz, Gülçin Özkara, Ahter T. Tayyar, Çiğdem Altunok Tags: Original article Source Type: research

Variables associated with mitochondrial copy number in human blastocysts: what can we learn from trophectoderm biopsies?
To study the potential variables that affect the mitochondrial DNA (mtDNA) content of trophectoderm (TE) cells in blastocysts that have undergone TE biopsy. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2018 Category: Reproduction Medicine Authors: Maria Jos é de los Santos, Antonio Diez Juan, Amparo Mifsud, Amparo Mercader, Marcos Meseguer, Carmen Rubio, Antonio Pellicer Tags: Original article Source Type: research

Kisspeptin as a new serum biomarker to discriminate miscarriage from viable intrauterine pregnancy
To validate the ability of serum kisspeptin-54 to discriminate between first-trimester viable pregnancies and miscarriages. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2018 Category: Reproduction Medicine Authors: Chantae Sullivan-Pyke, Daniel J. Haisenleder, Suneeta Senapati, Olivia Nicolais, Esther Eisenberg, Mary D. Sammel, Kurt T. Barnhart Tags: Original article Source Type: research

Postoperative complications after bowel endometriosis surgery by shaving, disc excision, or segmental resection: a three-arm comparative analysis of 364 consecutive cases
To assess the postoperative complications related to three surgical procedures used in colorectal endometriosis: rectal shaving, disc excision, and segmental resection. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2018 Category: Reproduction Medicine Authors: Carole Abo, Salwa Moatassim, Noemie Marty, Mathilde Saint Ghislain, Emmanuel Huet, Val érie Bridoux, Jean Jacques Tuech, Horace Roman Tags: Original article Source Type: research