Developmental trajectory of monopronucleated zygotes after in  vitro fertilization when they include both male and female genomes
To examine the cause of monopronucleated zygote (1PN) formation that includes both maternal and paternal genomes. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 18, 2021 Category: Reproduction Medicine Authors: Xingqiang Wei, Noritoshi Enatsu, Kohyu Furuhashi, Toshiroh Iwasaki, Shoji Kokeguchi, Masahide Shiotani, Junko Otsuki Tags: Original article Source Type: research

Individualized luteal phase support normalizes live birth rate in women with low progesterone levels on the day of embryo transfer in artificial endometrial preparation cycles
To analyze the impact on live birth rates (LBRs) of the individualized luteal phase support (termed iLPS) in patients with low serum progesterone (P) levels compared with patients without iLPS. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 18, 2021 Category: Reproduction Medicine Authors: Elena Labarta, Giulia Mariani, Cristina Rodr íguez-Varela, Ernesto Bosch Tags: Original article Source Type: research

Aqueous vaginal contrast and scheduled hematocolpos with magnetic resonance imaging to delineate complex m üllerian anomalies
To demonstrate the advantage of using aqueous vaginal contrast and scheduled hematocolpos with magnetic resonance imaging (MRI) to improve the delineation of gynecologic anatomy and to recommend that this modality be considered in patients with complex m üllerian anomalies. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 18, 2021 Category: Reproduction Medicine Authors: Phillip A. Romanski, Ashley Aluko, Pietro Bortoletto, Robert N. Troiano, Samantha M. Pfeifer Tags: Video Source Type: research

Renal agenesis, associated genital malformations, and responsible genes
The study of the possible genetic causes of complex genital malformations is a subject of great interest both to know its etiology and diagnosis and for the best genetic and reproductive advice in these patients. Recently, Chen et  al. (1) published the article titled “Perturbations of Genes Essential for Müllerian Duct and Wolffian Duct Development in Mayer-Rokitansky-Kuster-Hauser Syndrome,” and in this issue of Fertility and Sterility, Li et al. (2) reported that “whole-exome sequencing revealed that renal agenesi s-related genes were mutated and may be associated with the Herlyn-Werner-...
Source: Fertility and Sterility - September 18, 2021 Category: Reproduction Medicine Authors: Pedro Aci én, Maribel Acién Tags: Reflections Source Type: research

Outcomes of embryo transfers performed by Reproductive Endocrinology and Infertility fellows  vs. faculty: an 11-year retrospective review
To compare the clinical pregnancy rate (CPR) and live birth rate (LBR) of embryo transfer episodes (ETEs) performed by Reproductive Endocrinology and Infertility fellows vs. those of ETEs performed by faculty physicians. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 18, 2021 Category: Reproduction Medicine Authors: Colleen M. Miller, Amy L. Weaver, Yulian Zhao, Samir N. Babayev Tags: Original article Source Type: research

Reliability of the sperm chromatin dispersion assay to evaluate sperm deoxyribonucleic acid damage in men with infertility
To investigate the intraindividual agreement of the sperm chromatin dispersion (SCD) assay results to assess sperm DNA fragmentation (SDF) in men with infertility. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 18, 2021 Category: Reproduction Medicine Authors: Sandro C. Esteves, Carmen L ópez-Fernández, Mercedes González Martínez, Ellen A. Silva, Jaime Gosálvez Tags: Original article Source Type: research

Assessing efficacy of intravenous acetaminophen for perioperative pain control for oocyte retrieval: a  randomized, double-blind, placebo-controlled trial
To compare the effect of preoperative intravenous (IV) acetaminophen versus oral (PO) acetaminophen or placebo on postoperative pain scores and the time to discharge in women undergoing oocyte retrieval. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 18, 2021 Category: Reproduction Medicine Authors: Caitlin R. Sacha, Roisin Mortimer, Eduardo Hariton, Kaitlyn James, Afrooz Hosseini, Morgan Gray, Chengluan Xuan, Karissa Hammer, Allison Lange, Shruthi Mahalingaiah, Jingping Wang, John C. Petrozza Tags: Original article Source Type: research

Racial differences in men seeking fertility treatment in North America: a timely report by the Andrology Research Consortium
The coronavirus disease 2019 pandemic has amplified existing racial disparities in healthcare outcomes that reflect racial inequalities present throughout the structure of our society. There is no clearer demonstration of these disparities than the greater reduction in the already shorter life expectancy of black and Latino Americans compared with that of white Americans during 2020 (1). Although clinicians who treat infertility focus on birth rather than on death, the care we provide is not immune to unjust racial disparities. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 18, 2021 Category: Reproduction Medicine Authors: Bobby B. Najari Tags: Reflections Source Type: research

Early identification of women with endometriosisby means of a simple patient-completed questionnaire screening tool: a diagnostic study
To assess the value of a self-completed questionnaire based on patients ’ verbal descriptors of pelvic painful symptoms to identify women with endometriosis. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 16, 2021 Category: Reproduction Medicine Authors: Arnaud Fauconnier, Hocine Drioueche, Cyrille Huchon, Joseph Du Cheyron, Emilie Indersie, Yasmine Candau, Pierre Panel, Xavier Fritel Tags: Original article Source Type: research

Reproductive endocrinologists ’ knowledge and attitudes in the identification of intimate partner violence
To assess reproductive endocrinologists ’ attitudes, beliefs, knowledge, and experiences with intimate partner violence (IPV). (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 16, 2021 Category: Reproduction Medicine Authors: Seth J. Barishansky, Periel Shapiro, Gabrielle Meyman, Mary Ellen Pavone, Angela K. Lawson Tags: Original article Source Type: research

Endometrial thickness changes after progesterone administration do not affect the pregnancy outcomes of frozen-thawed euploid blastocyst transfer: a retrospective cohort study
To evaluate whether the change in endometrial thickness from progesterone administration day to transfer day is related to pregnancy outcomes in single frozen-thawed euploid blastocyst transfer cycles. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 15, 2021 Category: Reproduction Medicine Authors: Ziqi Jin, Hao Shi, Manman Lu, Zhiqin Bu, Mingzhu Huo, Yile Zhang Tags: Original article Source Type: research

Do frozen embryo transfers modify the epigenetic control of imprinted genes and transposable elements in newborns compared with fresh embryo transfers and natural conceptions?
To determine whether the epigenetic control of imprinted genes (IGs) and transposable elements (TEs) differs at birth between fresh or frozen embryo transfers and natural conceptions. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 15, 2021 Category: Reproduction Medicine Authors: Julie Barberet, Gaelle Romain, Christine Binquet, Magali Guilleman, C éline Bruno, Perrine Ginod, Caroline Chapusot, Cécile Choux, Patricia Fauque Tags: Original article Source Type: research

Falloposcopic tuboplasty: an easy, quick, and safe technique
To describe our simplified technique for falloposcopic tuboplasty (FT) and demonstrate its principle and results. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 15, 2021 Category: Reproduction Medicine Authors: Hidehiko Matsubayashi, Yukiko Takaya, Takumi Takeuchi, Masakazu Doshida, Yasuhiro Ohara, Tomomoto Ishikawa Tags: Video Source Type: research

Using pneumovaginoscopy to perform the removal of a vaginal fibroid
To describe and assess the feasibility of a novel surgical technique (pneumovaginoscopy) for performing vaginal surgery. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 15, 2021 Category: Reproduction Medicine Authors: Maud Allary, Aubert Agostini, Lisa Calderon, Laura Miquel, Patrice Crochet, Antoine Netter Tags: Video Source Type: research

Prevalence and performance of private equity-affiliated fertility practices in the United States
To quantify the proportion of annual assisted reproductive technology (ART) cycles performed at private equity-affiliated fertility practices and to test for differences in services and success rates between private equity-affiliated and nonaffiliated practices. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 15, 2021 Category: Reproduction Medicine Authors: Alexander Borsa, Joseph Dov Bruch Tags: Original article Source Type: research

Oocyte cryopreservation in women after childhood and adolescent cancer
Ovarian reserve impairment is common in childhood and in adolescent female tumor survivors. As their 5-year survival rates have continued to improve over the last few decades, with>80% of patients surviving into adulthood, fertility preservation has become an important quality-of-life issue for them. Because of this, a large body of literature explores fertility preservation of patients at the time of cancer diagnosis or early treatment. What has been lacking is fertility preservation discussion and treatments during and after cancer treatment. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 3, 2021 Category: Reproduction Medicine Authors: Huiying Li, Wenpei Xiang, Huai L. Feng Tags: Reflections Source Type: research

A management algorithm and proposed pathogenesis for retroperitoneal ectopic pregnancies
Although retroperitoneal ectopic pregnancies are rare (estimated at (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 3, 2021 Category: Reproduction Medicine Authors: Kathryn Coyne, Rebecca Flyckt, Joseph Findley Tags: Reflections Source Type: research

Delayed treatment or deferred treatment: What ’s intended? A commentary on national oocyte thaw outcomes data
The long-awaited national summary of oocyte thaw outcomes is finally available (1). In keeping with the mission of the Society for Assisted Reproductive Technology (SART) to set standards for fertility care, the release of this data establishes a much-anticipated and desperately needed benchmark for providers of oocyte thaw procedures. The authors of the report are to be commended for undertaking the analysis of the outcomes of oocyte cryopreservation at a national level. For too long, counseling patients about the expectations for thawed oocytes has been limited to data from individual clinics and reference to small serie...
Source: Fertility and Sterility - September 2, 2021 Category: Reproduction Medicine Authors: Eric Flisser Tags: Reflections Source Type: research

Toward a universal serum antim üllerian hormone threshold as a surrogate for polycystic ovarian morphology on ultrasound: the story is not over…
Although the serum antim üllerian hormone (AMH) assay has been proposed for approximately 20 years to replace or complement the results of transvaginal pelvic ultrasound (TVUS) in women with polycystic ovary syndrome (PCOS), no consensus threshold has been established to date (1). The reasons mainly are technical and metho dologic. In the absence of an international standard, it is impossible to homogenize the results of studies using different assay techniques. In addition, the criteria for selecting patients and control cases vary from one series to another. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 2, 2021 Category: Reproduction Medicine Authors: Didier Dewailly Tags: Reflections Source Type: research

Intramural myomas –related infertility: should the myomas be removed??? Not easy to reach a consensus
Several fibroids are asymptomatic, but in 30% –40% of cases, they show a variety of symptoms, depending on their location and size. They are increasingly observed in women requiring a medical opinion for infertility for two reasons: longer reproductive timeline in women thanks to improvements in medical care and current trend for women to pos tpone childbearing. Since publication of the review by Pritts et al. (1) and the clear message that women with submucosal myomas experience significantly lower implantation, clinical pregnancy, ongoing pregnancy, and live birth rates, as well as significantly higher miscarr...
Source: Fertility and Sterility - September 2, 2021 Category: Reproduction Medicine Authors: Jacques Donnez Tags: Fertile battle: introduction Source Type: research

Laparoscopically-confirmed endometriosis and risk of incident stroke: a prospective cohort study
Prior research has suggested that women with endometriosis are at greater risk of cardiovascular disease later in life, including myocardial infarction and hypertension. However, there has been limited research on endometriosis and risk of stroke, which may have similar underlying pathophysiologic mechanisms. Therefore, our objective was to prospectively investigate the association between laparoscopically-confirmed endometriosis and risk of incident stroke during 28 years of follow-up. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Leslie V. Farland, William J. Degnan, Melanie Bell, Kathryn M. Rexrode, Stacey A. Missmer Source Type: research

Mitoquinone rescues stress induced mitophagy in aged oocytes
The objective of this study was to investigate if maturing aged mouse oocytes with Mitoquinone (MQ) would improve oocyte mitochondrial quality by rescuing mitophagy. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Shaihla A. Khan, Heidi J. Engelhorn, Deirdre Logsdon, Rebecca Kile, Courtney Grimm, Benjamin B. Goheen, Laura Reed, William B. Schoolcraft, Ye Yuan, Rebecca L. Krisher Source Type: research

Dna double-strand breaks frequently cause chromosome loss in human embryos
Genome editing by DNA double-strand breaks (DSB) is currently being investigated as a tool to treat or even prevent heritable diseases. However, DNA repair mechanisms in the human embryo remain poorly understood and may result in small genetic variations such as indels, as well as large unwanted changes including loss of heterozygosity or the loss of a whole chromosome. Our study aims to determine outcomes of DNA repair after pericentromeric Cas9 cleavage in human preimplantation embryos. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Jenna M. Turocy, Michael V. Zuccaro, Diego Marin, Jia Xu, Nathan R. Treff, Dieter Egli Source Type: research

Disparities in surgical management of tubal ectopic pregnancy
To examine racial disparities in the surgical management of tubal ectopic pregnancy over time. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Alexandra G. Huttler, Christopher X. Hong, Divya Kelath Shah Source Type: research

Liberty randomized withdrawal study: 2-year efficacy and safety of relugolix combination therapy in women with heavy menstrual bleeding associated with uterine fibroids
In the pivotal LIBERTY 1 and 2 trials and Long-Term Extension (LTE) study, once-daily relugolix combination therapy (Rel-CT: relugolix 40 mg, estradiol 1 mg, norethindrone acetate 0.5 mg) reduced menstrual blood loss (MBL) volume and pain in women with uterine fibroids (UF). Rel-CT was well tolerated, with preservation of bone mineral density (BMD) through 52 weeks. Here we report results of the Phase 3 LIBERTY randomized withdrawal study (RWS), designed to evaluate the efficacy and safety of Rel-CT for up to 2 years. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Ayman Al-Hendy, Roberta Venturella, Juan Camilo Arjona Ferreira, Yulan Li, Rachel B. Wagman, Andrea S. Lukes Source Type: research

Ovarian tissue oocytes in vitro maturation as a method of fertility preservation in patients with gynecological cancer: a pilot study
Almost 100,000 new cases of gynecological cancers are diagnosed annually, and 15 –20% of these cases occur in women under the age of 40 [1]. For instance, 8% of endometrial cancer, 12% of ovarian cancer, and 40% of cervical cancer occur in women of reproductive age [2]. Often these patients have to go through radical ovariectomies. The standard methods of fertility preservatio n (FP) such as controlled ovarian stimulation or ovarian tissue cryopreservation might not be suitable for patients with gynecological cancer (GC). (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Anastasia Kirillova, Ekaterina Bunyaeva, Nona Mishieva, Aydar Abubakirov, Johan E.J. Smitz Source Type: research

Clinical benefits of culturing intracytoplasmic sperm injection-derived nonpronucleated (0pn) and monopronucleated (1pn) zygotes, and the importance of verifying biparental chromosome inheritance in 1pn-derived blastocysts
Evaluate the developmental competence and aneuploidy status of blastocysts derived from 0PN and 1PN zygotes following intracytoplasmic sperm injection (ICSI) and preimplantation genetic testing for aneuploidy (PGT-A). Elucidate biparental chromosome inheritance in female 1PN-derived blastocysts. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Kathryn Wozniak, Amy Jones, Minjae Kwon, Ping Zou, Mitchel C. Schiewe Source Type: research

The presence of cell extrusion or exclusion during embryonic compaction is associated with lower rates of blastocyst formation and poorer morphologic grade
To determine whether visualization of the embryonic compaction process through time-lapse imaging (TL) can assist in predicting likelihood of blastocyst formation, grade or ploidy. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Christine Hur, Vaani Nanavaty, Nina Desai Source Type: research

A randomised controlled blinded trial assessing the effectiveness of embryoglue as an embryo transfer medium in ivf cycles
To assess if the use of a hyaluronin-enriched embryo transfer medium [EmbryoGlue (Vitrolife, Sweden)] results in higher live birth rates in IVF cycles compared to standard transfer medium. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Tim J. Child, Aysha Bevan, Rebecca Frettsome-Hook, Jo Craig, Sevanna Shahbazian, Ginny Mounce Source Type: research

Live birth rates are significantly decreased following transfer of a euploid blastocyst with direct unequal cleavage
The objective of this study is to compare live birth (LB) rates following transfer of single frozen euploid blastocysts that either did or did not display DUC. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Chelsea N. Fortin, Erica E. Marsh, Yolanda R. Smith, John F. Randolph, Marie Menke, Min Xu Source Type: research

Making icsi more natural: selecting sperm bound to the zona pellucida (zp)
This study aims to test whether the use of ZP-bound sperm for ICSI can improve the fertilization, cleavage, and blastocyst formation rates as well as blastocyst quality. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Hager Abu Elmagd, Eman Mohamed Hasanen, Abd ElGhafar Hussin, Eman Anwar Mohamed, Nehal Abu-Elnaga, Hanaa Ahmed Alkhader, Hosam Zaki Source Type: research

Single-step vs sequential media: unbiased comparison of clinical outcome between two individual embryo culture strategies in a time-lapse incubator
To compare the on-going pregnancy rate (OGP) using two individual embryo culture strategies in a time-lapse incubator. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Mar ía de los Ángeles Valera, Lorena Bori, Fernando Meseguer, Elena Paya, Ma José de los Santos, Marcos Meseguer Source Type: research

Low-pass genome sequencing identified macroscopic and microscopic chromosomal mosaicisms to explain first-trimester miscarriage
To study the frequency and spectrum of macroscopic (site-to-site heterogeneity) and microscopic (uniform distribution of mosaic cells) chromosomal mosaicism on multiple chorionic villi sites from first-trimester miscarriage by low-pass genome sequencing (LP-GS). (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Ying LI, Zirui DONG, Kwong Wai Richard Choy, Pui Wah Jacqueline Chung Source Type: research

Mesenchymal stem cells induce bone marrow memory to reduce inflammation and endometriosis
Endometriosis is a chronic inflammatory gynecological disorder regulated by estrogen and characterized by the growth of endometrial tissue outside the uterus. Inflammation contributes to the pelvic pain, infertility and systemic effects of the disease. Mesenchymal stem cells contribute directly to endometriosis however they may also impact the bone marrow, regulating bone marrow-derived inflammatory cells. Here, we investigate the effect of mesenchymal stem cells on BM derived inflammatory cells using a murine model of endometriosis. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Ramanaiah Mamillapalli, Shutaro Habata, Hugh S. Taylor Source Type: research

Bedside test to rule out an ectopic pregnancy using a modified fda approved kit
To evaluate the accuracy of a modified bedside test in ruling out an ectopic pregnancy. The test is based on a lateral flow immunoassay for alpha-fetoprotein (AFP). It has been shown that a high AFP level in vaginal blood indicates the passage of fetal tissue, suggestive of a miscarriage [1]. We hypothesized that high AFP levels in sampled intrauterine tissue, assuming non-heterotopic pregnancy, rules out the presence of an ectopic pregnancy. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Michelle Volovsky, Maria G. Duarte, Hugh S. Taylor, Amir Mor Source Type: research

Luteal phase progesterone support in ivf cycles is rendered redundant unless it is hydroxylated to 17- Α-hydroxyprogesterone (17-Α-ohp); a molecule that robustly stipulates endometrial receptivity and predicts pregnancy outcomes
To evaluate 17- α-hydroxyprogesterone (17-α-OHP) levels in post embryo transfer (ET) serum samples as a determinant of endometrial receptivity and pregnancy outcomes in IVF cycles (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Bindu N. Chimote, Natchandra Manoharrao Chimote Source Type: research

Anxiety during the covid-19 pandemic: preliminary findings from the ucsf aspire study
To describe the prevalence of anxiety symptoms in early pregnancy and identify predictors of early pregnancy anxiety during the COVID-19 pandemic. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Jerrine R. Morris, Eleni Greenwood Jaswa, Amy Kaing, Eduardo Hariton, Miriam Andrusier, Katie E. Aliaga, Maya Inez Davis, Lauri Pasch, Marcelle I. Cedars, Heather G. Huddleston Source Type: research

Treatment outcomes after highly-purified human menopausal gonadotropin (hp-hmg) ovarian stimulation and luteal support with a novel progesterone vaginal system (pvs): sara trial analysis
To characterize key parameters associated with the use of HP-hMG and PVS in a bridging study designed to evaluate the safety and efficacy of PVS after implementation of manufacturing enhancements. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Vicki L. Schnell, Eric D. Foster, Sarah A. Grover, Patrick W. Heiser Source Type: research

Optimal number of euploid embryos needed to achieve a desired family size: a personalized predictive model
This study aims to build a model incorporating personalized factors to assist patients in determining how many euploid embryos would convey a high likelihood of achieving a desired family size. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Devora Aharon, Guillaume Stoffels, Dmitry Gounko, Tamar Alkon, Joseph A. Lee, Eric Flisser, Alan B. Copperman, Erkan Buyuk Source Type: research

Does harvesting ovarian tissue to delay reproductive aging have a negative impact on the natural age of menopause in healthy women?
Given the increasing success rates of ovarian tissue cryopreservation and autologous transplantation, ASRM has removed this approach from the list of experimental fertility preservation procedures. The advances in ovarian cryopreservation and transplantation techniques led to the question of whether it can also be used to delay reproductive aging and provide a natural form of hormone replacement therapy. However, it is currently unknown if ovarian biopsies obtained for elective purposes will cause a reduction in reproductive lifespan not matched by the longevity of the transplanted tissue. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Boris Petrikovsky, Loris Marin, Kutluk H. Oktay Source Type: research

The impact of duration of oocyte cryopreservation on live birth outcomes in ivf cycles using autologous thawed oocytes
To evaluate whether duration of autologous oocyte vitrification has an impact on in-vitro fertilization (IVF) cumulative live birth rates (cLBR) after fresh or frozen embryo transfers. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Grace Elizabeth Whiteley, Anne E. Martini, Samad Jahandideh, Kate Devine, Micah J. Hill, Alan H. DeCherney, Joseph Doyle, Caleb Kallen Source Type: research

Cycle characteristics and treatment outcomes among brca mutation carriers undergoing in vitro fertilization
To evaluate the differences in vitro fertilization (IVF) treatment utilization patterns and outcomes between BRCA and non-BRCA mutation carriers (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Luwam A. Ghidei, Joie Zeynep Guner, Ashley M. Wiltshire, Laurie McKenzie, Terri L. Woodard Source Type: research

Ripe for the taking – leveraging big data to estimate ovarian reserve
Elucidating the impact of cancer treatments on ovarian reserve is central to fertility preservation decisions, but longitudinal measures of ovarian reserve markers like anti-mullerian hormone (AMH) in traditional prospective cohort studies are challenged by cost, sample size, and follow up. We hypothesized that AMH trajectories derived from administrative health claims data would differ by breast cancer status and chemotherapy exposures. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Beth Zhou, Brian Kwan, Milli Desai, Vinit Nalawade, Nina Veeravalli, James D. Murphy, Brian W. Whitcomb, Hui-Chun I. Su Source Type: research

Effect of malignant disease on semen parameters
Although the harmful effect of testicular cancer and Hodgkin lymphoma on semen quality is well documented, the results regarding the impact of other cancer types on semen parameters and the effect of the presence of malignant disease in general are inconclusive. Here we compared semen characteristics in cryopreserved semen samples of various pathologies to samples taken from men who attended the same reproductive center, whose semen parameters are above the reference limit, and to semen parameters from the WHO 2020 fertile men cohort. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Guy Shrem, Liat Azani, Michael H. Dahan, Mali Salmon-Divon Source Type: research

Assessment of common adverse events of relugolix combination therapy in premenopausal women treated for symptomatic estrogen-driven conditions: liberty and spirit studies
Relugolix is a once-daily, oral nonpeptide gonadotropin-releasing hormone receptor antagonist being developed in combination with estradiol (E2) and norethindrone acetate (NETA) to treat heavy menstrual bleeding (HMB) associated with uterine fibroids (UF) and moderate-to-severe pain associated with endometriosis (EM). In the Phase 3 LIBERTY 1/2 trials for UF (n=770), relugolix combination therapy (Rel-CT [once-daily relugolix 40 mg, E2 1 mg, NETA 0.5 mg]) reduced HMB vs placebo. In the SPIRIT 1/2 trials for EM (n=1251), Rel-CT reduced dysmenorrhea, non-menstrual pelvic pain and dyspareunia vs placebo. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Ayman Al-Hendy, Sawsan As-Sanie, Juan Camilo Arjona Ferreira, Yulan Li, Rachel B. Wagman, Linda C. Giudice Source Type: research

Inhibition of brd proteins suppresses the phenotype of uterine fibroids via regulation of n6-methyladenosine regulators
Bromodomain (BRD)-containing proteins are involved in many biological processes, most notably epigenetic regulation of transcription, and BRD protein dysfunction has been linked to many diseases including tumorigenesis. However, the role of BRD proteins in the pathogenesis of uterine fibroids (UFs), the most common pelvic tumors in women of reproductive age, is unknown. The present study aimed to determine the expression pattern of BRD proteins in UFs and matching myometrium and assess the effect of BRD inhibitors on UF phenotype and epitranscriptomic changes. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Qiwei Yang, Mohamed Ali, Chuan He, Thomas G. Boyer, Ayman Al-Hendy Source Type: research

Transcriptomics analysis shows profound ethnic differences in at risk pre-fibroid myometrium
Uterine fibroids (UF) are the most common noncancerous gynecologic tumors presented in reproductive-age women. It is well known that UF disproportionately affects African American (AA) women, being more prevalent and severe in them compared with European American (EA) population. To date, we understand little about the underlying causes of the ethnic disparity. This work aimed to identify transcriptomic signatures and regulated pathways involved in at-risk myometrium in the context of UF, in AA and EA women, using RNA-seq approach. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Maria Victoria Bariani, Sandra L. Grimm, Mohamed Ali, Cristian Coarfa, Qiwei Yang, Ayman Al-Hendy Source Type: research

Hypoxia induces angiogenesis and proliferation in uterine fibroid cells
Angiogenesis is the physiological process by which new blood vessels grow from pre-existing vessels and is a crucial step for tumor growth and development. Multiple angiogenic growth factors are differentially expressed in uterine fibroid compared with myometrium, but the mechanisms regulating fibroid angiogenesis remains still unclear. Oxygen concentration in fibroids was reported to be significantly lower than the surrounding myometrium. The pathophysiologic response of fibroid to hypoxic condition remains largely unknown. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Mariko Miyashita-Ishiwata, Malak El Sabeh, Sadia Afrin, Mostafa A. Borahay Source Type: research

Aberrant expression of n6-methyladenosine regulators in uterine fibroids from the eker rat model
The epitranscriptome is an emerging frontier in molecular medicine owing to its vast potential as an additional and highly dynamic layer of gene regulation above and beyond the epigenome. To date, more than 160 different chemical modifications in RNA have been identified in living organisms; among these, N6-methyladenosine (m6A) is the most pervasive, abundant, and conserved internal modification within eukaryotic mRNAs. However, knowledge of epitranscriptomics in uterine fibroids (UFs), the most common pelvic tumors in women of reproductive age, is currently limited. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Qiwei Yang, Maria Victoria Bariani, Chuan He, Thomas G. Boyer, Ayman Al-Hendy Source Type: research

Effects of relugolix combination therapy on bone mineral density through 2 years in women with heavy menstrual bleeding associated with uterine fibroids
Relugolix 40 mg is a non-peptide gonadotropin-releasing hormone receptor antagonist being developed for use in combination with estradiol 1 mg and norethindrone acetate 0.5 mg (relugolix combination therapy; Rel-CT) to treat heavy menstrual bleeding (HMB) associated with uterine fibroids (UF). The rationale for combination therapy is to mitigate anticipated hypoestrogenic effects with relugolix monotherapy, including bone loss. Rel-CT preserved bone mineral density (BMD) in the pivotal LIBERTY 1/2 trials and Long-Term Extension (LTE) study. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2021 Category: Reproduction Medicine Authors: Michael R. McClung, Andrea S. Lukes, Roberta Venturella, Arthur C. Santora, Dongmei Zhai, Rachel B. Wagman, Ayman Al-Hendy Source Type: research