Transvaginal natural orifice transluminal endoscopic surgery tubal reanastomosis: a novel route for tubal surgery
To demonstrate how a transvaginal natural orifice transluminal endoscopic surgery (NOTES) tubal reanastomosis is a novel route for tubal surgery. The surgical technique is a combination of traditional vaginal surgery with single-site surgical skills. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 21, 2018 Category: Reproduction Medicine Authors: Juan Liu, Elise Bardawil, Qiongyan Lin, Binhua Liang, Weiqun Wang, Chunhua Wu, Xiaoming Guan Tags: Video Source Type: research

The use of combined hormonal contraceptives for the treatment of  endometriosis-related pain: a systematic review of the evidence
To review the available clinical evidence on the use of combined hormonal contraceptive (CHC) agents (estrogen [E]-progestin combinations) for the treatment of endometriosis-related pain. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 21, 2018 Category: Reproduction Medicine Authors: Jeffrey T. Jensen, William Schlaff, Keith Gordon Tags: Original article Source Type: research

Endometrioma-related reduction in ovarian reserve (ERROR): a prospective longitudinal study
To evaluate whether endometrioma is associated with a progressive decline in ovarian reserve, and to compare the rate of decline with natural decline in ovarian reserve. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 20, 2018 Category: Reproduction Medicine Authors: Isil Kasapoglu, Baris Ata, Ozlem Uyaniklar, Ayse Seyhan, Adnan Orhan, Sule Yildiz Oguz, Gurkan Uncu Tags: Original article Source Type: research

Improving care for women with polycystic ovary syndrome
Depression is one of the leading causes of global disease burden, with a prevalence of 3% –8% worldwide. In a 2016 survey reported by the National Institute of Mental Health, the prevalence of major depressive episodes was higher in females compared with males (8.5% vs. 4.5%) and highest in Caucasians and adults between 18 and 25 years of age (1). A significant proportion of adults (64 %) reported impairment with a major depressive episode, and 34% received no treatment. Among adolescent females, the prevalence of depression was 19.4%, and 60% reported receiving no treatment. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 19, 2018 Category: Reproduction Medicine Authors: Anuja Dokras Tags: Reflections Source Type: research

Original investigations into the diagnosis and treatment of ejaculatory dysfunction
Schellen T. Induction of ejaculation by electrovibration. Fertil Steril 1968;19(4):566 –9.“The method employed is simple, harmless and—above all—not objectionable to patients. In cases such as those described, it is preferable to other therapeutic measures, which are too often both prolonged and useless.”Girgis SM, Etriby A, El-Hefnawy H, Kahil S. Aspermia: a survey of 49 ca ses. Fertil Steril 1968;19(4):580–8.“Retrograde ejaculation was associated with stricture of the urethra of long standing. A tight stricture may allow passage of urine but not semen, which is more viscid.&rdquo...
Source: Fertility and Sterility - June 19, 2018 Category: Reproduction Medicine Authors: Martin Kathrins Tags: Fertility and sterility: 50 years ago today Source Type: research

First in  vitro fertilization baby—this is how it happened
On July 25, 1978, the first human was born following extracorporeal fertilization, an event that opened up a new medical science: expanding our knowledge of and developing novel treatments for infertility, radically changing the opportunities for families with inherited monogenic disorders, generating the new discipline of clinical embryology, and paving the way for studies into stem cell biology. In  vitro fertilization (IVF), as it became known in its simplest form, went even further: it engaged the myriad of minds in human society. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 13, 2018 Category: Reproduction Medicine Authors: Simon Fishel Tags: Views and reviews Source Type: research

Insulin resistance is associated with depression risk in polycystic ovary syndrome
To test the hypothesis that insulin resistance is associated with depression risk in polycystic ovary syndrome (PCOS). (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 13, 2018 Category: Reproduction Medicine Authors: Eleni A. Greenwood, Lauri A. Pasch, Marcelle I. Cedars, Richard S. Legro, Esther Eisenberg, Heather G. Huddleston, National Institute of Child Health and Human Development Reproductive Medicine Network Tags: Original article Source Type: research

Maternal diabetes mellitus and timing of pubertal development in daughters and sons: a nationwide cohort study
To study the association between maternal diabetes and timing of pubertal development in daughters and sons. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 13, 2018 Category: Reproduction Medicine Authors: Lea L.B. Lauridsen, Linn H. Arendt, Andreas Ernst, Nis Brix, Erik T. Parner, J ørn Olsen, Cecilia H. Ramlau-Hansen Tags: Original article Source Type: research

Effects of chronic endometritis therapy on in  vitro fertilization outcome in women with repeated implantation failure: a systematic review and meta-analysis
To evaluate the impact of antibiotic therapy for chronic endometritis (CE) on IVF outcome. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 13, 2018 Category: Reproduction Medicine Authors: Amerigo Vitagliano, Carlo Saccardi, Marco Noventa, Attilio Di Spiezio Sardo, Gabriele Saccone, Ettore Cicinelli, Sara Pizzi, Alessandra Andrisani, Pietro Salvatore Litta Tags: Original article Source Type: research

Oil-based versus water-based contrast for hysterosalpingography in infertile women: a systematic review and meta-analysis of randomized controlled trials
To determine the effect of the using oil-soluble contrast material (OSCM) vs. water-soluble contrast material (WSCM) for hysterosalpingography on pregnancy rates in infertile women. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 13, 2018 Category: Reproduction Medicine Authors: Fang Fang, Yu Bai, Yu Zhang, Andrew Faramand Tags: Original article Source Type: research

Tubal anastomosis: once in a blue moon?
Reflecting imparts the pleasant memory of something special, notable and memorable. In the past century, “blue moon” has been used to denote the moment where a second full moon occurs within a calendar month, which happens once in three years. However, two blue moons in a year is quite rare. Just this year, we had the unique opportunity to see blue moons in both January and March. Owing to the meto nic cycle, we will not experience two of these in the same year again until 2037. As with the blue moon, we ask whether tubal anastomosis has become too infrequent of a distinctive event to be worth remembering, offe...
Source: Fertility and Sterility - June 13, 2018 Category: Reproduction Medicine Authors: Stephanie J. Estes, Balasubramanian Bhagavath, Steven R. Lindheim Tags: Reflections Source Type: research

Pregnancy outcomes from more than 1,800 in  vitro fertilization cycles with the use of 24-chromosome single-nucleotide polymorphism–based preimplantation genetic testing for aneuploidy
To measure in  vitro fertilization (IVF) outcomes following 24-chromosome single‒nucleotide-polymorphism (SNP)–based preimplantation genetic testing for aneuploidy (PGT-A) and euploid embryo transfer. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 13, 2018 Category: Reproduction Medicine Authors: Alexander L. Simon, Michelle Kiehl, Erin Fischer, J. Glenn Proctor, Mark R. Bush, Carolyn Givens, Matthew Rabinowitz, Zachary P. Demko Tags: Original article: Assisted reproduction Source Type: research

Cognitive-behavioral therapy improves weight loss and quality of life in women with polycystic ovary syndrome: a pilot randomized clinical trial
To compare the effects of cognitive-behavioral therapy (CBT) and lifestyle modification (LS) versus LS alone on weight, depressive and anxiety symptoms, and stress response in women with polycystic ovary syndrome (PCOS), overweight/obesity, and depressive symptoms. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 13, 2018 Category: Reproduction Medicine Authors: Laura G. Cooney, Lauren W. Milman, Liisa Hantsoo, Sara Kornfield, Mary D. Sammel, Kelly C. Allison, C. Neill Epperson, Anuja Dokras Tags: Original article Source Type: research

Blastocyst development rate influences implantation and live birth rates of similarly graded euploid blastocysts
To determine whether the blastocyst development rate, as assessed by the day of trophectoderm biopsy (day 5 vs. day 6), affects the live birth rate (LBR) of similarly graded euploid blastocysts. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 13, 2018 Category: Reproduction Medicine Authors: Mohamad Irani, Claire O'Neill, Gianpiero D. Palermo, Kangpu Xu, Chenhui Zhang, Xiaoe Qin, Qiansheng Zhan, Robert N. Clarke, Zhen Ye, Nikica Zaninovic, Zev Rosenwaks Tags: Original article Source Type: research

Improved outcomes after blastocyst-stage frozen-thawed embryo transfers compared with cleavage stage: a Society for Assisted Reproductive Technologies Clinical Outcomes Reporting System study
To investigate whether there is a difference in obstetrical and perinatal outcomes in blastocyst frozen-thawed embryo transfers (FETs) compared with cleavage-stage FET. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 13, 2018 Category: Reproduction Medicine Authors: Emily C. Holden, Banafsheh N. Kashani, Sara S. Morelli, Donald Alderson, Sangita K. Jindal, Pamela A. Ohman-Strickland, Peter G. McGovern Tags: Original article Source Type: research

Are combined hormonal contraceptives the neglected treatment for symptomatic endometriosis?
I want a new drug. —Huey Lewis and the News (Chrysalis, UK, 1984)An approximate answer to the right question is worth a great deal more than a precise answer to the wrong question.—John Tuckey, American statistician (https://en.wikiquote.org/wiki/John_Tukey. Accessed March 18, 2018) (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 13, 2018 Category: Reproduction Medicine Authors: Paolo Vercellini Tags: Reflections Source Type: research

Posthumous retrieval and use of gametes or embryos: an Ethics Committee opinion
Earn online CME credit related to this document at www.asrm.org/elearn (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 13, 2018 Category: Reproduction Medicine Authors: Ethics Committee of the American Society for Reproductive Medicine Tags: ASRM pages Source Type: research

Intergenerational effects —causation or confounding?
One can get a glimpse into the early origins of long-term reproductive health by assessing pubertal onset. Studies of pubertal development not only provide insight into reproductive health but may also have broader implications. Reproductive health outcomes and infertility in both men and women have come to be recognized as a window into the overall health of an individual —shedding light on risk for later chronic health outcomes. For example, semen quality in men is predictive of mortality and general health, and gynecologic conditions in women have been linked to metabolic disorders and cardiovascular disease. (Sou...
Source: Fertility and Sterility - June 8, 2018 Category: Reproduction Medicine Authors: Sunni L. Mumford, Edwina H. Yeung Tags: Reflections Source Type: research

Use of indocyanine green in endometriosis surgery
To report and visually demonstrate the feasibility of using indocyanine green (ICG) in endometriosis surgery and to discuss potential benefits. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 6, 2018 Category: Reproduction Medicine Authors: Yochay Bar-Shavit, Lucie Jaillet, Pauline Chauvet, Michel Canis, Nicolas Bourdel Tags: Video Source Type: research

Impact of the levonorgestrel-releasing intrauterine device on controlled ovarian stimulation outcomes
To report differences in ovarian stimulation outcomes in women using a levonorgestrel-releasing intrauterine device (LNG-IUD). (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 6, 2018 Category: Reproduction Medicine Authors: Amanda J. Adeleye, Lusine Aghajanova, Chia-Ning Kao, Marcelle I. Cedars, Mark V. Sauer Tags: Original article Source Type: research

A stepped-care approach to symptomatic endometriosis management: a participatory research initiative
To assess the proportion of patients with symptomatic endometriosis satisfied with their medical treatment 12  months after enrollment in a stepped-care management protocol. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 2, 2018 Category: Reproduction Medicine Authors: Paolo Vercellini, Agnese Donati, Federica Ottolini, Annalisa Frassineti, Jessica Fiorini, Vanessa Nebuloni, Maria Pina Frattaruolo, Anna Roberto, Paola Mosconi, Edgardo Somigliana Tags: Original article Source Type: research

Antim üllerian hormone as a risk factor for miscarriage in naturally conceived pregnancies
To determine the association between antim üllerian hormone (AMH), a measure of ovarian reserve, and miscarriage among naturally conceived pregnancies. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 2, 2018 Category: Reproduction Medicine Authors: Brianna M. Lyttle Schumacher, Anne Marie Z. Jukic, Anne Z. Steiner Tags: Original article Source Type: research

Elevated incidence of monozygotic twinning is associated with extended embryo culture, but not with zona pellucida manipulation or freeze-thaw procedure
To identify the incidence and risk factors associated with IVF-conceived monozygotic twinning (MZT). (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 2, 2018 Category: Reproduction Medicine Authors: Hanyan Liu, Jianqiao Liu, Shiping Chen, Xiangjin Kang, Hongzi Du, Lei Li Tags: Original article Source Type: research

Appraisal of clinical complications after 23,827 oocyte retrievals in a large assisted reproductive technology program
To assess complications encountered after transvaginal oocyte retrieval procedures. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 2, 2018 Category: Reproduction Medicine Authors: Paolo Emanuele Levi-Setti, Federico Cirillo, Valeria Scolaro, Emanuela Morenghi, Francesca Heilbron, Donatella Girardello, Elena Zannoni, Pasquale Patrizio Tags: ORIGINAL ARTICLE: Assisted reproduction Source Type: research

Elevated levels of adrenomedullin in eutopic endometrium and plasma from women with endometriosis
To test adrenomedullin (Adm, ADM) as a downstream target of signal transducer and activator of transcription 3 (STAT3) in endometrial cells and to test midregional proadrenomedullin (MR-proADM) as a biomarker of endometriosis. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 2, 2018 Category: Reproduction Medicine Authors: Brooke C. Matson, Kelsey E. Quinn, Bruce A. Lessey, Steven L. Young, Kathleen M. Caron Tags: Original article Source Type: research

Cumulative live birth rates in more than 3,000 patients with poor ovarian response: a 15-year survey of final in  vitro fertilization outcome
To estimate the cumulative live birth rates (CLBRs) in women with poor ovarian response (POR) diagnosed according to the Bologna criteria. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: Bei Xu, Yingjia Chen, Dirk Geerts, Jing Yue, Zhou Li, Guijin Zhu, Lei Jin Tags: Original article Source Type: research

Same-day confirmation of intrauterine pregnancy failure in women with first- and early second-trimester bleeding
To determine if alpha-fetoprotein (AFP) concentration in vaginal blood, in the setting of dissolved fetal tissue, is significantly higher than its concentration in the maternal serum. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: Amir Mor, Reshef Tal, Shoshana Haberman, Bharati Kalgi, Susan Hosseini Nasab, Howard Minkoff Tags: Original article Source Type: research

Karyotype of the blastocoel fluid demonstrates low concordance with both trophectoderm and inner cell mass
To compare the genomic profiles of blastocoel fluid (BF), inner cell mass (ICM), and trophectoderm (TE) cells derived from the same blastocyst. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: Olga T šuiko, Daria I. Zhigalina, Tatjana Jatsenko, Nikolay A. Skryabin, Olga R. Kanbekova, Victoria G. Artyukhova, Anatoly V. Svetlakov, Katre Teearu, Aleksander Trošin, Andres Salumets, Ants Kurg, Igor N. Lebedev Tags: Original article Source Type: research

Cumulative pregnancy rates in women with poor ovarian response
Counseling patients with poor ovarian response (POR) is a challenge owing to conflicting data and anecdotal experiences of clinicians. Some of the confusion is due to the lack of uniform criteria for the diagnosis of POR. The Bologna criteria for POR was established in 2011. However, a recent article by Boza et  al. found that only 51% of articles regarding POR published since the establishment of the Bologna criteria used it (1). (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: James M. Goldfarb Tags: Reflections Source Type: research

Reconsidering vasectomy reversal over assisted reproduction in older couples
To provide pregnancy and live birth rates from a contemporary series of vasectomy reversals in men with female partners aged ≥35 years and to correlate the results with IVF. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: Akash A. Kapadia, Marcus Anthony, Ann Martinez Acevedo, Eugene F. Fuchs, Jason C. Hedges, Kevin A. Ostrowski Tags: Original article Source Type: research

Randomized controlled trial of low (5%) versus ultralow (2%) oxygen for extended culture using bipronucleate and tripronucleate human preimplantation embryos
To determine whether [1] exposure of embryos to 5% oxygen (O2) from day 1 (D1) to D3, and then to 2% O2 from D3 to D5, improves total blastocyst yield, as compared with continuous exposure to 5% O2; and [2] extended culture in 2% O2 alters key metabolic processes and O2-regulated gene expression in human preimplantation embryos. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: Daniel J. Kaser, Berhan Bogale, Vishnudas Sarda, Leslie V. Farland, Paige L. Williams, Catherine Racowsky Tags: Original article Source Type: research

Clinical use of endovenous indocyanine green during rectosigmoid segmental resection for endometriosis
To describe a new use of endovenous indocyanine green (ICG) to allow real-time visualization of bowel perfusion in women with recto-sigmoid endometriosis who may be candidates for segmental resection. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: Renato Seracchioli, Diego Raimondo, Alessandro Arena, Margherita Zanello, Mohamed Mabrouk Tags: Original article Source Type: research

Mutational and functional studies on NR5A1 gene in 46,XY disorders of sex development: identification of six novel loss of function mutations
To study the functional properties of six novel missense mutations of the NR5A1 gene encoding the steroidogenic factor 1 (SF-1) identified in six patients with 46,XY disorders of sex development (DSD) and to describe their relative phenotype –genotype relationship. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: Maria Santa Rocca, Rita Ortolano, Soara Menab ò, Federico Baronio, Alessandra Cassio, Gianni Russo, Antonio Balsamo, Alberto Ferlin, Lilia Baldazzi Tags: Original article Source Type: research

Surgery for deep endometriosis without involvement of digestive or urinary tracts: do not worry the patients!
To report postoperative outcomes after surgery for deep endometriosis without involvement of the digestive or urinary tracts. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: Aur élie Vallée, Stéphane Ploteau, Carole Abo, Emanuela Stochino-Loi, Salwa Moatassim-Drissa, Noémie Marty, Benjamin Merlot, Horace Roman Tags: Original article Source Type: research

Burden of care is the primary reason why insured women terminate in  vitro fertilization treatment
To study the reason(s) why insured patients discontinue in  vitro fertilization (IVF) before achieving a live birth. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: Alice D. Domar, Kristin Rooney, Michele R. Hacker, Denny Sakkas, Laura E. Dodge Tags: Original article Source Type: research

Good-quality blastocysts derived from vacuolized morulas show reduced viability
To study whether late spontaneous vacuolization on day 4 is an artefact or an alternate means of blastocele formation and to analyze its impact on pregnancy outcome and live birth. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: Richard B. Mayer, Omar Shebl, Peter Oppelt, Elisabeth Reiter, Reinhard Altmann, S. Enengl, Christina Allerstorfer, Thomas Ebner Tags: Original article Source Type: research

Role of adrenomedullin in reproduction and endometriosis
Adrenomedullin (AM) is a peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. Production of AM is up-regulated by several factors, such as oxidative stress, proinflammatory cytokines, angiotensin II, hypoxia, and hyperglycemia. It is synthesized as a part of the precursor preproadrenomedullin. It performs various biologic functions in different systems of the body. It acts as both a hormone and a cytokine to regulate blood flow, vascular tone, leucocyte migration, electrolyte imbalance, and hormone secretion (1). (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: Mohamed Aboulghar Tags: Reflections Source Type: research

Use of emergency contraception among female young adult cancer survivors
To test whether emergency contraception use in reproductive-aged cancer survivors is higher than in the general U.S. population and evaluate factors associated with use among survivors. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: Alexa C.O. Medica, Shaylyn S. Stark, Tracy N. Hadnott, Andrew C. Dietz, Sally A.D. Romero, Loki Natarajan, Elena Martinez, Brian W. Whitcomb, H. Irene Su Tags: Original article Source Type: research

Antim üllerian hormone and miscarriage: fifty shades of gray…
Antim üllerian hormone (AMH) is a glycoprotein secreted primarily by the granulosa cells of preantral and early antral follicles, although it is secreted by granulosa cells of any follicle that has developed beyond the primordial follicle stage. Despite the precise function of AMH in female reproduction being uncertain, several lines of evidence point to AMH acting as a brake on follicular recruitment and development, with AMH antagonizing several of the biochemical aspects of FSH vis-à-vis effects on granulosa cells. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: A. Musa Zamah, Mary D. Stephenson Tags: Reflections Source Type: research

Contraception and reproductive health counseling in cancer survivorship —plan A rather than plan B
With improving survival rates among adolescent and young adults (AYA) with cancer, reproductive health has become an important focus of pre- and post-treatment care. While many organizations have urged providers to discuss infertility risk and offer fertility preservation options before cancer therapy (1), less concrete guidance is available regarding fertility and other aspects of reproductive health in survivorship. Fertility-related distress and uncertainty about fertility status have frequently been noted among male and female cancer survivors (2). (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: Leena Nahata, Gwendolyn P. Quinn Tags: Reflections Source Type: research

Dilemma of postvasectomy procreative management with older female partners: is in  vitro fertilization really better?
The determination of how to manage a couple who present for fertility postvasectomy should involve a complete, informed, honest, unbiased discussion of all the options tailored to the couple without conflicts of specialty (gynecology vs. urology) and financial interests. Therefore, this should be based on the complete understanding of the literature for vasectomy reversal, assisted reproduction technology (ART) options, and outcomes as well as alternative options, for example, donor sperm with IUI versus adoption or maintaining the status quo. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: Ajay K. Nangia Tags: Reflections Source Type: research

A message from the Fertility and Sterility Video and New Media Editor
Have you seen the Fertility and Sterility Dialog (https://www.fertstertdialog.com/)? The updated Fertility and Sterility Dialog recently launched and is awaiting your participation! (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: Kurt Barnhart Tags: Editorial Source Type: research

Reduction in oxygen tension to 2% in extended culture: a more physiologic system may mean more blastocysts available for transfer
Since the earliest days of IVF, embryo culture systems have been designed to mimic the in  vivo environment to the highest degree possible. Exhaustive studies of the normal conditions of the female reproductive tract have produced our contemporary culture systems, with carefully calibrated amino acid and carbohydrate substrate levels, precise pH control, and tight temperature regulation . However, the facet of embryo culture that has perhaps received the greatest research attention is oxygen tension. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: Scott J. Morin Tags: Reflections Source Type: research

Comparison of pregnancy rates for poor responders using IVF with mild ovarian stimulation versus conventional IVF: a guideline
Earn online CME credit related to this document at www.asrm.org/elearn (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: Practice Committee of the American Society for Reproductive Medicine Tags: ASRM pages Source Type: research

Personalized reproductive medicine: regulatory considerations
Personalized medicine has many definitions. This term is often used synonymously with precision medicine, which is defined as the classifying patients with a disease or condition based on their phenotypic findings, such as biomarkers or genomics, into subpopulations that differ in their response to a specific treatment. Personalized medicine, however, can also mean the treatment of individual patients based on many contextual factors, such as response to therapy and patient preferences, in addition to predefined phenotypic findings. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: Jonathan P. Jarow Tags: Views and reviews Source Type: research

Endometriosis: frightening the patients is not an acceptable alternative to inadequate surgical management and or pathophysiology ignorance
Endometriosis management is a permanent controversy. Based on the concept that the disease is chronic and will inevitably recur if a permanent amenorrhea is not obtained, and assuming that surgery may induce severe complications, many investigators have proposed long-term medical management of all patients diagnosed and or suspected to have endometriosis (1). Surgery would be reserved for a failure with medical treatment: persistent pain despite amenorrhea being attained. This “all-medical approach” may also be favored by the patients who have been extensively counseled about surgical complications. (Source: Fe...
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: Michel Canis, Nicolas Bourdel, Pauline Chauvet Tags: Reflections Source Type: research

Alpha-fetoprotein in vaginal blood: a promising novel marker for early pregnancy failure that needs further validation
Early pregnancy loss is a common obstetric complication and is often preceded by vaginal bleeding. It is estimated that as many as 12% to 15% of all clinically recognizable pregnancies and up to 22% of all pregnancies end in miscarriage (1). In women of advanced reproductive age, the miscarriage rate may approach 75%. Bleeding in early pregnancy is a common reason for women to seek acute care through the emergency department or in early pregnancy units. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: Beata E. Seeber Tags: Reflections Source Type: research

Use of preimplantation genetic testing for monogenic defects (PGT-M) for adult-onset conditions: an Ethics Committee opinion
Earn online CME credit related to this document at www.asrm.org/elearn (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: Ethics Committee of the American Society for Reproductive Medicine Tags: ASRM pages Source Type: research

Using observational data for personalized medicine when clinical trial evidence is limited
Randomized clinical trials are considered the preferred approach for comparing the effects of treatments, yet data from high-quality clinical trials are often unavailable and many clinical decisions are made on the basis of evidence from observational studies. Using clinical examples about the management of infertility, we discuss how we can use observational data from large and information-rich health-care databases combined with modern epidemiological and statistical methods to learn about the effects of interventions when clinical trial evidence is unavailable or not applicable to the clinically relevant target populati...
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: Boris Gershman, David P. Guo, Issa J. Dahabreh Tags: Views and reviews Source Type: research

Scurvy and embryo culture
Lind, founder of naval hygiene in England, wrote a classic treatise on scurvy, in which he described the first deliberately planned controlled therapeutic trial ever undertaken:I took 12 patients …with scurvy…[who] had one diet common to all.Two of these were ordered each a quart of cyder a day.Two others took twenty-five drops of elixir of vitriol…Two others took two spoonfuls of vinegar…Two…were put upon a course of seawater….Two others had two oranges and one lemon…every day .Two remaining patients took an electuary…made of garlic, mustard, balsam of peru and myrrh...
Source: Fertility and Sterility - June 1, 2018 Category: Reproduction Medicine Authors: Kurt T. Barnhart Tags: Inklings Source Type: research