Resveratrol depolarizes the membrane potential in human granulosa cells and promotes mitochondrial biogenesis
To study the biological effects of resveratrol on the growth, electrophysiology, and mitochondrial function of human granulosa cells (h-GCs). (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 21, 2021 Category: Reproduction Medicine Authors: Francesco Ragonese, Lorenzo Monarca, Antonella De Luca, Loretta Mancinelli, Monica Mariani, Cristina Corbucci, Sandro Gerli, Rossana Giulietta Iannitti, Lucio Leonardi, Bernard Fioretti Tags: Original article Source Type: research

Endometrium preparation and perinatal outcomes in women undergoing single-blastocyst transfer in frozen cycles
To investigate the association of endometrium preparation with perinatal outcomes. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 21, 2021 Category: Reproduction Medicine Authors: Kai-Lun Hu, Dan Zhang, Rong Li Tags: Original article Source Type: research

Clinical trial to evaluate pharmacokinetics and pharmacodynamics of medroxyprogesterone acetate after subcutaneous administration of Depo-Provera
To evaluate the pharmacokinetics and pharmacodynamics of medroxyprogesterone acetate after a single subcutaneous injection in the abdomen of 150 or 300 mg Depo-Provera and compare results to two injections of Depo-SubQ Provera 104 given 3 months apart. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 20, 2021 Category: Reproduction Medicine Authors: Vera Halpern, Vivian Brache, Douglas Taylor, Anja Lendvay, Leila Coch ón, Jeffrey T. Jensen, Laneta J. Dorflinger Tags: Original article Source Type: research

Ovaries of patients recently treated with alkylating agent chemotherapy indicate the presence of acute follicle activation, elucidating its role among other proposed mechanisms of follicle loss
To investigate mechanisms of primordial follicle (PMF) loss in  vivo in human ovaries shortly after alkylating agent (AA) chemotherapy. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 20, 2021 Category: Reproduction Medicine Authors: Daniel Shai, Sarit Aviel-Ronen, Itai Spector, Hila Raanani, Moran Shapira, Itai Gat, Hadassa Roness, Dror Meirow Tags: Original article Source Type: research

Psychosocial determinants of women ’s intentions and willingness to freeze their eggs
To examine the psychosocial factors that influence Australian women ’s intentions to freeze their eggs. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 18, 2021 Category: Reproduction Medicine Authors: Lucy E. Caughey, Katherine M. White Tags: Original article Source Type: research

Evaluating Efficacy of Intravenous Carbetocin in Reducing Blood Loss During Abdominal Myomectomy: A Randomized Controlled Trial
To evaluate the efficacy of carbetocin versus placebo in decreasing intraoperative blood loss and the need for blood transfusion during abdominal myomectomy. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 16, 2021 Category: Reproduction Medicine Authors: Ayman Taher, Dalia Farouk, Mohamed Mahmoud Mohamed Kotb, Nevein Kamal Ghamry, Khaled Kholaif, Ahmed A. Mageed A. Allah, Ahmed Said Ali, Omneya M. Osman, Hala Nabil, Yomna Islam, Mohamed Sobhy Bakry, Bassem Aly Islam, Mahmoud Alalfy, Salma Ashraf Nassar, A Tags: Original article Source Type: research

Perspectives of 281 patients with Mayer-Rokitansky-K üster-Hauser Syndrome on uterine transplantation
To investigate the personal, ethical, and financial perspectives of individuals with Mayer −Rokitansky−Küster−Hauser syndrome (MRKH), a congenital uterine factor infertility condition, regarding uterine transplantation (UTx). (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 16, 2021 Category: Reproduction Medicine Authors: Nicole Fischer, Helen Xun, Amy Lossie, Darya Fadavi, Halley Darrach, Pooja Yesantharao, Franca Kraenzlin, Bhuchitra Singh, Justin M. Sacks, James H. Segars Tags: Original article Source Type: research

Seeking the elusive genes associated with varicocele: a step forward
It is well established that varicocele can harm testicular function and fertility, mainly through thermal damage and oxidative stress (1). However, the reasons why the disease affects each individual ’s fertility in differing ways are not entirely understood. Moreover, the exact genetic background of familial varicocele and whether genetic factors increase the predisposition to varicocele occurrence are unknown. The multiplicity of phenotypes associated with varicocele suggests a complex multi factorial disorder in which genetic, epigenetic, and environmental factors seem to play a decisive role (1, 2). (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 15, 2021 Category: Reproduction Medicine Authors: Viviane P. Santana, Sandro C. Esteves Tags: Reflections Source Type: research

Routine endometrial receptivity array in first embryo transfer cycles does not improve live birth rate
To compare the live birth rate between patients who undergo personalized embryo transfer (pET) after endometrial receptivity array (ERA) versus frozen embryo transfer (FET) with standard timing in first single euploid FET cycles. To report the rate of displacement of the window of implantation (WOI) in an infertile population without a history of implantation failure. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 15, 2021 Category: Reproduction Medicine Authors: Carrie Riestenberg, Lindsay Kroener, Molly Quinn, Kaycee Ching, Gayane Ambartsumyan Tags: Original article Source Type: research

Modified Vecchietti vaginoplasty using self-made single-port laparoscopy in Mayer-Rokitansky-K üster-Hauser syndrome
To introduce the minimally invasive Vecchietti procedure based on single-port laparoscopy with self-made surgical instruments for the surgical management of Mayer-Rokitansky-K üster-Hauser syndrome (MRKH). (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 15, 2021 Category: Reproduction Medicine Authors: Xinyun Yang, Junxiao Liang, Wenjuan Li, Bingya Chen, Xiaoyan Sun, Zhenwei Xie Tags: Video Source Type: research

Miscarriage determination in first trimester based on alpha-fetoprotein extracted from sanitary pads
To determine if high alpha-fetoprotein (AFP) level in vaginal blood collected on a sanitary pad can assist with detecting an active miscarriage. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 15, 2021 Category: Reproduction Medicine Authors: Amir Mor, Mursal Gardezi, Karen Jubanyik, Burcin Simsek, David B. Seifer, Pasquale Patrizio, Ecem Esencan, Gizem Imamoglu, Man Zhang, Stephanie M. Nichols-Burns, Hugh S. Taylor Tags: Original article Source Type: research

An investigation into the effect of potential confounding patient and treatment parameters on human embryo morphokinetics
To determine the effect of patient and treatment parameters on 19 embryo morphokinetic parameters using pronuclear fading as time zero. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 15, 2021 Category: Reproduction Medicine Authors: Amy Barrie, Garry McDowell, Stephen Troup Tags: Original article Source Type: research

Machine-learning algorithm incorporating capacitated sperm intracellular pH predicts conventional in  vitro fertilization success in normospermic patients
To measure human sperm intracellular pH (pHi) and develop a machine-learning algorithm to predict successful conventional in  vitro fertilization (IVF) in normospermic patients. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 15, 2021 Category: Reproduction Medicine Authors: Stephanie Jean Gunderson, Lis Carmen Puga Molina, Nicholas Spies, Paula Ania Balestrini, Mariano Gabriel Buffone, Emily Susan Jungheim, Joan Riley, Celia Maria Santi Tags: Original article Source Type: research

Adverse obstetric and perinatal outcomes in 1,136 singleton pregnancies conceived after programmed frozen embryo transfer (FET) compared with natural cycle FET
To investigate whether obstetric and perinatal outcomes in pregnancies differ after different frozen embryo transfer (FET) protocols. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 15, 2021 Category: Reproduction Medicine Authors: Louise Laub Asserh øj, Anne Lærke Spangmose, Anna-Karina Aaris Henningsen, Tine Dalsgaard Clausen, Søren Ziebe, Rikke Beck Jensen, Anja Pinborg Tags: Original article Source Type: research

A predictive model for chemotherapy-related diminished ovarian reserve in reproductive-age women
To develop and internally validate a clinical predictive tool to assess the likelihood that a young cancer patient will experience diminished ovarian reserve (DOR) after chemotherapy. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 14, 2021 Category: Reproduction Medicine Authors: Margaret M. Hopeman, Katherine E. Cameron, Maureen Prewitt, Kurt Barnhart, Jill P. Ginsberg, Mary D. Sammel, Clarisa R. Gracia Tags: Original article Source Type: research

Is in  vitro fertilization the answer in polycystic ovary syndrome?
After several cycles of unsuccessful clomiphene citrate induction, offering in  vitro fertilization (IVF) to patients with infertility related to polycystic ovary syndrome (PCOS) is standard practice. With the rising rates of IVF success in many cases of unexplained infertility, the costs—monetary or otherwise—of IVF are accepted by both patients and health care providers . However, even with carefully standardized protocols, we still often find that PCOS patients with an especially high body mass index (BMI) struggle with achieving clinical pregnancy and have lower live-birth rates (1). (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 14, 2021 Category: Reproduction Medicine Authors: Sajal Gupta, Annika Sinha Tags: Reflections Source Type: research

Infection precautions for SARS-CoV-2 in assisted reproduction centers – dodging an invisible bullet
Capsule: SARS-CoV-2 infection risks and mitigation strategies for assisted reproductive centers are reviewed. Implementation of safety precautions are suggested based on current literature and society guidelines. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 14, 2021 Category: Reproduction Medicine Authors: Amy E.T. Sparks, Jessica D. Kresowik Tags: Views and reviews Source Type: research

Development and validation of a novel mail-in semen analysis system and the correlation between one hour and delayed semen analysis testing
To develop and validate a novel, mail-in semen analysis (SA) system. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 8, 2021 Category: Reproduction Medicine Authors: Mary K. Samplaski, Owen Falk, Stanton Honig, David Shin, William Matthews, James F. Smith Tags: Original article Source Type: research

Withholding antibiotics does not reduce clinical pregnancy outcomes of natural cycle frozen embryo transfers
To assess the impact of withholding doxycycline on the success rate of natural cycle frozen embryo transfers (NC-FET). (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 8, 2021 Category: Reproduction Medicine Authors: Isabel Beshar, Jasmyn K. Johal, Brindha Saravanabavanandhan, Amin A. Milki Tags: Original article Source Type: research

Mayer-Rokitansky-K üster-Hauser syndrome associated with fused renal ectopia and hydroureter
The video presentation entitled “Mayer−Rokitansky−Küster−Hauser syndrome with rare findings of crossed-fused renal ectopia and Gartner’s duct cyst: a video case report” presents treatment of vaginal agenesis and reimplantation of hydro-ureter into the bladder (1). This is a wonderful report of a rare combined Mülleri an and renal anomaly, and highlights the diverse spectrum of anomalies that exist. The video presentation is a nice demonstration of the Davydov procedure, with a detailed step-by-step depiction of dissection in the vessico-rectal space to create a neovaginal space...
Source: Fertility and Sterility - January 5, 2021 Category: Reproduction Medicine Authors: Samantha M. Pfeifer Tags: Reflections Source Type: research

Laparoscopic single-stapler technique in rectosigmoid resection in women with deep infiltrating endometriosis
To demonstrate the use of a single-stapler technique during rectosigmoid resection in women with deep infiltrating endometriosis (DIE). (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 4, 2021 Category: Reproduction Medicine Authors: Jiri Hanacek, Lukas Havluj, Noble Ayayee, Iva Urb ánková, Jan Drahonovsky Tags: Video Source Type: research

Improving access to procreative care through affordable hysteroscopic myomectomy
Enhanced access to procreative care resonates with patients and clinicians. This stems from our belief in justice and equity. Ethics teaches us that high-quality healthcare should be a right, and not just a privilege for the economically fortunate few. Our American Society for Reproductive Medicine (ASRM) Ethics Committee guidelines acknowledge this reality by noting, “Economic barriers are the chief contributors to disparities in access to effective treatment” (1). Although acknowledging the need for research on biological causes of infertility, such as fibroids, polycystic ovary syndrome, and azoospermia, the...
Source: Fertility and Sterility - January 4, 2021 Category: Reproduction Medicine Authors: J. Preston Parry Tags: Reflections Source Type: research

Ethanol sclerotherapy for endometriomas: ready for prime time?
Nearly all reproductive health professionals have encountered the dilemma of the dreaded endometrioma, particularly for patients pursuing assisted reproductive technology (ART). For example, consider a patient with a 4-cm endometrioma that obstructs the pathway to follicular aspiration for oocyte retrieval. The clinician is then left with two options to offer the patient. One option is to proceed with egg retrieval and potentially miss aspiration of follicles resulting in lower oocyte yield. The alternative option is to proceed with laparoscopic ovarian cystectomy, which incurs the risk of decreasing ovarian reserve, as we...
Source: Fertility and Sterility - January 1, 2021 Category: Reproduction Medicine Authors: Susan Nasab, Bronwyn S. Bedrick, Mindy S. Christianson Tags: Reflections Source Type: research

The times they are a-changin ’: Isn’t it time to expand the trainee curriculum?
The prospect of completing formal training from medical school, to residency, to fellowship, and to entering the workforce is what drives most of us. The innate goal that is driven home by our teachers and mentors is to learn best practices and develop a skill set that allows for the provision of a specialty level of care. The hope is we all feel well prepared by the time that new role comes to fruition and have a sense of being able to function as an independent reproductive endocrinologist. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2021 Category: Reproduction Medicine Authors: Priyanka Ghosh, Mindy Christianson, Joseph Sanfilippo, Steven R. Lindheim Tags: Inklings Source Type: research

The need for business in reproductive medicine
The business of medicine continues to be an area of growing importance, particularly in reproductive medicine. We provide a synthesis of salient concepts within the spectrum of business in medicine. The topics we review include finances and accounting; business operations as related to human resources, information technology (telemedicine), organizational governance, and practice models; insurance billing and contract negotiations; and the impact of health care policy on reproductive medicine. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2021 Category: Reproduction Medicine Authors: Steven R. Lindheim, Mindy S. Christianson, Joseph Sanfilippo Tags: Views and reviews Source Type: research

Glycemic status and fertility —implications for preconception care
There is an increasing interest in understanding the relationship between overall health status and fertility, both in how poor health may impact fertility and in how poor fertility may affect health status later in life. Much of the focus to date has been on clinically overt disease. For example, there is a growing literature showing that time to conception is longer for women with diabetes than for women without diabetes (1). Conversely, women with a history of infertility also seem to be at greater risk of developing diabetes (2). (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2021 Category: Reproduction Medicine Authors: Jorge E. Chavarro Tags: Reflections Source Type: research

Peripheral lymphocyte telomere dysfunction: a valid surrogate marker for female fertility?
Telomeres are multiple short tandem DNA repeat sequences (5 ′-TTAGGG-3′), that cap the ends of linear chromosomes and bind a specialized telomere protein complex called shelterin to form telomere loops. The telomeres function to protect the genome from degradation, unwanted deletion, or recombination (chromosome end fusions and genomic instability) to ma intain its genetic integrity. Without telomere protection, DNA damage response pathways result in cell cycle arrest, genomic instability, apoptosis, or senescence. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2021 Category: Reproduction Medicine Authors: Ramya Sethuram, Ali A. Bazzi, Sana M. Salih, Elizabeth E. Puscheck Tags: Reflections Source Type: research

How organoids from endometrium and endometriosis could help to understand the pathogenesis of endometriosis
The article on methylation of HOX genes (1) in endometrium and endometriosis organoids is carefully performed and important research. Organoids, or the in  vitro culture of cells as three-dimensional structures, are a rapidly developing new technology. The most important advantage of organoids is their phenotypic and genetic stability and long-lasting commitment to the tissue of origin during long-term culture (2). This characteristic was previously found only in specific immortalized monolayer cultured cell lines, which unfortunately differed from the original cells in many aspects. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2021 Category: Reproduction Medicine Authors: Philippe R. Koninckx, Anastasia Ussia, Dan C. Martin Tags: Reflections Source Type: research

Billing, coding, and practice management: a primer for today ’s reproductive medicine professional
Despite years of recognition that many physicians are woefully unprepared to face challenges regarding the business of medicine, marginal progress has been made. In this piece, we aim to provide the contemporary reproductive medicine physician with an understanding of billing, coding, and, most importantly, cost containment for a typical fertility practice. It is critical for modern practices to not forego hard-earned revenue to insurance companies or not be aware of critical rules and regulations. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2021 Category: Reproduction Medicine Authors: Bala Bhagavath, Linnea Goodman, John Petrozza Tags: Views and reviews Source Type: research

Thank You to Our Reviewers
No journal can be successful without the support of professionals in the field who donate their time and expertise in reviewing manuscripts. Below is the list of reviewers who submitted their comments between November 1, 2019 and October 31, 2020. We would like to express our sincere gratitude to all of them. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2021 Category: Reproduction Medicine Tags: From the editors Source Type: research

Editorial Board
(Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2021 Category: Reproduction Medicine Source Type: research

Table of Contents
(Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2021 Category: Reproduction Medicine Source Type: research

The Effects of COVID-19 on Pregnancy and Implications for Reproductive Medicine
COVID-19 during pregnancy is associated with adverse maternal and obstetric outcomes. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2021 Category: Reproduction Medicine Authors: Naima T. Joseph, Sonja A. Rasmussen, Denise J. Jamieson Tags: Views and reviews Source Type: research

The impact of SARS-CoV-2 and COVID-19 on Male Reproduction and Men ’s Health
Capsule: SARS-CoV-2 is unlikely to be detected in human semen, however viral tropism for the male reproductive tract and the impact on both male hormones and semen parameters remains incompletely characterized. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2021 Category: Reproduction Medicine Authors: Darshan P. Patel, Nahid Punjani, Jingtao Guo, Joseph P. Alukal, Philip S. Li, James M. Hotaling Tags: Views and reviews Source Type: research

Legal considerations in reproductive medicine
Legal issues affect reproductive medical practice throughout the entire world. The breadth and depth of this interrelationship extend far beyond the scope of one series of articles in Views and Reviews. Given this limitation, we have chosen to present five topics, all different, but illustrative of key concepts that influence our practice of reproductive medicine. Our hope is that this “medical-legal sampler” will both inform and provoke thoughtful consideration of the ways we can best and most responsibly practice and serve our patients. (Source: Fertility and Sterility)
Source: Fertility and Sterility - December 30, 2020 Category: Reproduction Medicine Authors: Susan L. Crockin, William D. Schlaff Tags: Views and reviews Source Type: research

Promises and pitfalls of male contraceptive vaccines
I have not failed. I ’ve just found 10,000 ways that won’t work.—Thomas A. Edison (Source: Fertility and Sterility)
Source: Fertility and Sterility - December 30, 2020 Category: Reproduction Medicine Authors: Jennifer B. Bakkensen, Eve C. Feinberg Tags: Fertility and Sterility: 50 years ago today Source Type: research

An oncofertility prediction tool? Forecasting fertility after cancer
As cancer survival rates increase among adolescents and young adults, the need for fertility preservation awareness and counseling has grown in parallel. Although general negative predictors of future fertility after cancer treatment are recognized, Hopeman et  al. (1) further define the risk associated with certain clinical variables—including age, cancer diagnosis, and chemotherapy treatment—in their prospective cohort study, “A Predictive Model for Chemotherapy-Related Diminished Ovarian Reserve in Reproductive-Aged Women.” (Source: Fertility and Sterility)
Source: Fertility and Sterility - December 29, 2020 Category: Reproduction Medicine Authors: Paula C. Brady, Eric J. Forman Tags: Reflections Source Type: research

Emerging therapies for endometriosis
Although endometriosis is one of the most common gynecologic diseases, treatment options have long been limited. Commonly used medications include nonsteroidal antiinflammatory drugs, progestins (including those in oral contraceptives), danazol, and GnRH agonists. Danazol and GnRH agonist use are associated with significant side-effects. Progestins use may also result in side-effects, including mood changes, breakthrough bleeding, breast tenderness, and bloating. Furthermore, progestins are not always effective; progestin resistance is common, occurring in 30% –50% of women using progestin-based therapies for endomet...
Source: Fertility and Sterility - December 29, 2020 Category: Reproduction Medicine Authors: Hugh S. Taylor Tags: Reflections Source Type: research

Reproductive medicine, as seen through single-cell glasses
Progress in science depends on new techniques, new discoveries, and new ideas, probably in this order. —Sydney Brenner, 2002 Nobel Prize Winner in Physiology of Medicine (Source: Fertility and Sterility)
Source: Fertility and Sterility - December 29, 2020 Category: Reproduction Medicine Authors: Felipe Vilella, Carlos Simon Tags: Inklings Source Type: research

Association between circadian rhythm disruption and polycystic ovary syndrome
To explore the association of circadian rhythm disruption with polycystic ovary syndrome (PCOS) and the potential underlying mechanism in ovarian granulosa cells (GCs). (Source: Fertility and Sterility)
Source: Fertility and Sterility - December 23, 2020 Category: Reproduction Medicine Authors: Fangfang Wang, Ningning Xie, Yan Wu, Qing Zhang, Yuhang Zhu, Minchen Dai, Jue Zhou, Jiexue Pan, Mengling Tang, Qi Cheng, Biwei Shi, Qinyuan Guo, Xinling Li, Lifeng Xie, Bing Wang, Dongxia Yang, Qing Weng, Lanzhong Guo, Jisheng Ye, Mingwo Pan, Shuyi Zhang, Tags: Original article Source Type: research

Efficacy of the second micro –testicular sperm extraction after failed first micro–testicular sperm extraction in men with nonobstructive azoospermia
To evaluate the efficacy of the second micro –testicular sperm extraction (TESE)in men with nonobstructive azoospermia in whom the first micro-TESE failed. (Source: Fertility and Sterility)
Source: Fertility and Sterility - December 23, 2020 Category: Reproduction Medicine Authors: Oktay Özman, Süleyman Tosun, Numan Bayazıt, Sami Cengiz, Mustafa Emre Bakırcıoğlu Tags: Original article Source Type: research

Simulation training for embryo transfer: findings from the American Society for Reproductive Medicine Embryo Transfer Certificate Course
To assess the value of the American Society for Reproductive Medicine Embryo Transfer Certificate Course in confidence and skill building for performing a live embryo transfer (ET). (Source: Fertility and Sterility)
Source: Fertility and Sterility - December 23, 2020 Category: Reproduction Medicine Authors: Sarah D. Ramaiah, Keith A. Ray, Richard H. Reindollar Tags: Original article Source Type: research

A review of best practices of rapid-cooling vitrification for oocytes and embryos: a committee opinion
The focus of this paper is to review best practices for rapid-cooling cryopreservation of oocytes and embryos. The discussion of best practices includes the types of cryoprotectants and cryo devices typically used. Key performance indicators of rapid-cooling vitrification success are defined. (Source: Fertility and Sterility)
Source: Fertility and Sterility - December 23, 2020 Category: Reproduction Medicine Authors: Practice Committees of the American Society for Reproductive Medicine and Society of Reproductive Biologists and Technologists Tags: ASRM pages Source Type: research

In  vitro maturation: a committee opinion
The results of in  vitro maturation (IVM) investigations suggest the potential for wider clinical application. This document discusses the efficacy of IVM as reported in the published literature to date. This document replaces the document of the same name, last published in 2013. (Source: Fertility and Sterility)
Source: Fertility and Sterility - December 23, 2020 Category: Reproduction Medicine Authors: Practice Committees of the American Society for Reproductive Medicine, the Society of Reproductive Biologists and Technologists, and the Society for Assisted Reproductive Technology Tags: ASRM pages Source Type: research

Business law issues for assisted reproductive technology practices and practitioners: considerations for sales or mergers of fertility practices
This article will explore what factors physician owners of fertility practices should consider before pursuing a potential sale or merger; how to prepare for such a transaction; and what to expect once a transaction is underway. (Source: Fertility and Sterility)
Source: Fertility and Sterility - December 21, 2020 Category: Reproduction Medicine Authors: Richard M. Yanofsky, Theodore F. Hanselman Tags: Views and reviews Source Type: research

The heart of the matter: balancing potential cardiovascular risks with known benefits of gender-affirming testosterone
Over the past few years, as visibility and acceptance of gender diversity have increased, the number of people identifying as transgender or nonbinary has been rising. Based on 2015 data, transgender people comprise 0.58% of the adult U.S. population, or about 1.9 million people. A large majority of transgender people (78%) express interest in, or are currently using, gender-affirming hormones (1). However, there is little long-term safety data on the use of gender-affirming hormones, and recommendations and counseling are often extrapolated from studies in hypogonadal men, postmenopausal women, and women with polycystic o...
Source: Fertility and Sterility - December 21, 2020 Category: Reproduction Medicine Authors: Daphna Stroumsa, Amanda R. Schwartz, Molly B. Moravek Tags: Reflections Source Type: research

Fertility —a human right worthy of mandated insurance coverage: the evolution, limitations, and future of access to care
We review the history, current status, and potential future of state infertility mandates and focus on the business implications of mandates and on the inadequacies and reproductive injustice resulting from gaps between legislative intent and practical implementation. Nineteen states have passed laws that require insurers to either cover or offer coverage for infertility diagnoses and treatment. The qualifications for coverage, extent of coverage, and exemptions vary drastically from one state to another, resulting in deficiencies in access to care even within mandated states for certain groups, such as single individuals,...
Source: Fertility and Sterility - December 18, 2020 Category: Reproduction Medicine Authors: Jennifer F. Kawwass, Alan S. Penzias, Eli Y. Adashi Tags: Views and reviews Source Type: research

Accelerated subcutaneous abdominal stem cell adipogenesis predicts insulin sensitivity in normal-weight women with polycystic ovary syndrome
To examine whether subcutaneous (SC) abdominal adipose stem cell differentiation into adipocytes in  vitro predicts insulin sensitivity (Si) in vivo in normal-weight women with polycystic ovary syndrome (PCOS) and controls. (Source: Fertility and Sterility)
Source: Fertility and Sterility - December 17, 2020 Category: Reproduction Medicine Authors: Daniel A. Dumesic, Ayli Tulberg, Karen L. Leung, Samantha C. Fisch, Tristan R. Grogan, David H. Abbott, Rajanigandha Naik, Gregorio D. Chazenbalk Tags: Original article Source Type: research

Why are some patients with 45,X Turner syndrome fertile? A young girl with classical 45,X Turner syndrome and a cryptic mosaicism in the ovary
To report a case of a young girl initially diagnosed with exclusively 45,X Turner syndrome (TS), but with a cryptic mosaicism in the ovary. (Source: Fertility and Sterility)
Source: Fertility and Sterility - December 17, 2020 Category: Reproduction Medicine Authors: Sapthami Nadesapillai, Janielle van der Velden, Dominique Smeets, Guillaume van de Zande, Didi Braat, Kathrin Fleischer, Ronald Peek Tags: Original article Source Type: research

My mama had endometriosis
Endometriosis continues to wear “many hats” in the lives of women and the physicians who care for them. Not referenced here is the progress that has been made in understanding the pathophysiology of the disease and the pain and infertility that result. The article by Tuominen et al. compares obstetrical outcomes in a relative ly large number of women presenting with rectovaginal endometriosis (RVE) (1). On review of the literature, there are studies highlighting specific pregnancy outcomes from women with RVE and comparing reproductive success in women with RVE treated with either conservative management o...
Source: Fertility and Sterility - December 16, 2020 Category: Reproduction Medicine Authors: William E. Gibbons Tags: Reflections Source Type: research