Predictive value of cytoplasmic granulation patterns during in  vitro fertilization in metaphase II oocytes: Part I, poor-prognosis patients
To determine whether 4 cytoplasmic granulation patterns of human metaphase II oocytes have a predictive value for in  vitro fertilization outcomes. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 15, 2021 Category: Reproduction Medicine Authors: Jianjun Hu, Emanuela Molinari, Sarah Darmon, Lin Zhang, Pasquale Patrizio, David H. Barad, Norbert Gleicher Tags: Original article Source Type: research

Postwash total motile sperm count and intrauterine insemination pregnancy rate: how low can you go?
Quoting monthly success rates of natural or medicated intrauterine insemination (IUI) cycles to couples with infertility can be a lesson in bracing oneself for disappointing people. Depending on which study you reference, the success rates usually range from 10% to 20% per month. Even in the group with the best prognosis —a truly anovulatory patient with no history of infertility partnered with a fertile male—the fecundity rate is approximately 15% per ovulation event (1). Patient reactions are often a mixture of disillusionment and honest surprise at the limitations of their own reproductive ability. (Source: ...
Source: Fertility and Sterility - April 15, 2021 Category: Reproduction Medicine Authors: Phillip A. Romanski, Hey-Joo Kang Tags: Reflections Source Type: research

Stepping safely into the tiger country of endometriosis: approaching sacral endometriosis
Endometriosis is a chronic gynecologic condition affecting 6% –10% of reproductive-aged women. It is a condition in which endometrium-like tissue is aberrantly present outside of the uterus. It may present with a variety of symptoms, locations of the disease, and level of severity. The subtypes of endometriosis lesions include superficial, endometrioma, and deeply infiltrating endometriosis (DIE). Although most lesions involve the pelvic peritoneum, ovaries, and uterosacral ligaments (1), other structures may be involved, including the parametrium and pelvic nerves. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 15, 2021 Category: Reproduction Medicine Authors: Adela G. Cope, Zaraq Khan Tags: Reflections Source Type: research

Humor in reproductive medicine — the good, the bad, and the funny
The use of humor in medicine is an old concept that frequently comes under scrutiny. There is a diverse range of areas where humor is utilized and may play a role in medicine. Bennett has grouped humor in medicine into a variety of categories, including humor and health, humor and physician-patient communication, humor and patient care, humor and the health professional, humor in medical education, and humor in the medical literature (1). There is clear evidence that humor, when applied to patients, has health benefits, such as lowering blood pressure, decreasing pain and thus resulting in less need for pain medications, a...
Source: Fertility and Sterility - April 15, 2021 Category: Reproduction Medicine Authors: Mark Sigman Tags: Inklings Source Type: research

The endometrial response to modulation of ligand-progesterone receptor pathways is reversible
To study the impact of the progesterone receptor modulator (PRM), ulipristal acetate (UPA), on endometrial morphology and function. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 14, 2021 Category: Reproduction Medicine Authors: Rohan R. Chodankar, Alison Murray, Moira Nicol, Lucy H.R. Whitaker, Alistair R.W. Williams, Hilary O.D. Critchley Tags: Original article Source Type: research

Insulin resistance: still an underestimated factor in polycystic ovary syndrome?
While in the past polycystic ovary syndrome (PCOS) was considered mainly a reproductive disorder, defined by oligoovulation or anovulation, hyperandrogenism (HA), and polycystic ovarian morphology, in the last years it has become more evident that PCOS extends far beyond menstrual or reproductive problems. In fact, it has been shown to be associated with profound metabolic abnormalities, leading to a higher risk of developing type 2 diabetes (T2D) and cardiovascular diseases in later years of life (1). (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 14, 2021 Category: Reproduction Medicine Authors: Anna Lena Zippl, Beata Seeber, Ludwig Wildt Tags: Reflections Source Type: research

S1P and activin A induce fibrotic phenotype in uterine fibroids: a promising target for antifibrotic therapy
Uterine fibroids are characterized by excessive deposition of extracellular matrix (ECM) proteins, such as collagens, fibronectin, and proteoglycans that characterize fibrosis. Collagens in fibroids contribute to fibroid stiffness and increased mechanical stress is translated into biochemical signals, which include the activation of integrin/Rho/mitogen-activated protein kinase (MAPK) pathway. Growth factors, such as transforming growth factor- β (TGF-β), promote the fibrotic process through activation of Smad signaling. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 14, 2021 Category: Reproduction Medicine Authors: Md Soriful Islam, Most Mauluda Akhtar, James H. Segars Tags: Reflections Source Type: research

Polycystic ovary syndrome: an intrinsic risk factor for diabetes compounded by obesity
Polycystic ovary syndrome (PCOS) is a common reproductive, metabolic, and psychological condition affecting 8% –13% of women. It is 80% heritable with the intrauterine environment altering fetal development, insulin resistance from childhood, hyperandrogenism from puberty, and adverse impacts from disproportionally increased obesity. The Rotterdam PCOS diagnostic criteria are internationally accepted in ev idence-based guidelines and adults need two of the following features: oligoovulation, multiple follicles on ultrasound, and hyperandrogenism, either clinical or biochemical (1). (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 14, 2021 Category: Reproduction Medicine Authors: Helena J. Teede, Chau Thien Tay, Anju E. Joham Tags: Reflections Source Type: research

Antibiotic therapy for chronic endometritis and its reproductive implications: a step forward, with some uncertainties
During the last 2 decades, there has been growing interest in the study of endometrial pathologies and their reproductive implications. Chronic endometritis (CE), defined as the abnormal invasion of plasma cells within the endometrial stroma, has been one of the most investigated conditions (1 –5). (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 14, 2021 Category: Reproduction Medicine Authors: Ettore Cicinelli, Rossana Cicinelli, Amerigo Vitagliano Tags: Reflections Source Type: research

After the thaw: when patients return to use cryopreserved oocytes
Given the widespread use of oocyte cryopreservation (colloquially, “egg freezing”) in modern reproductive medicine, it is almost unfathomable that the procedure was considered “experimental” less than a decade ago. When the American Society for Reproductive Medicine and Society for Assisted Reproductive Technology (SART) removed the “experimental” label in 2012, their joint practice guideline specifically cautioned against the use of egg freezing as a safeguard against age-related fertility decline, citing insufficient data regarding safety, efficacy, cost-effectiveness, and emotional ri...
Source: Fertility and Sterility - April 14, 2021 Category: Reproduction Medicine Authors: Jennifer B. Bakkensen, Kara N. Goldman Tags: Reflections Source Type: research

F & S ___ style revision SARS-CoV-2 infection in IVF pregnancies Perinatal outcomes of pregnancies resulting from assisted reproduction technology in SARS-CoV-2 infected women: a prospective observational study.
To evaluate the perinatal and maternal outcomes of pregnancies in SARS-CoV-2 infected women, comparing spontaneous and In Vitro Fertilization (IVF) pregnancies (with either own or donor oocytes). (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 12, 2021 Category: Reproduction Medicine Authors: Virginia Engels Calvo, Sara Cruz Melguizo, Alejandra Abascal-Saiz, Laura Forc én Acebal, Amalia Sánchez-Migallón, Pilar Pintado Recart, Celia Cuenca Marín, Beatriz Marcos Puig, Pablo G. Del Barrio Fernández, Olga Nieto Velasco, María Luisa de la Cru Tags: Assisted reproduction Source Type: research

Adenomyosis is associated with specific proton nuclear magnetic resonance (1H-NMR) serum metabolic profiles
To determine whether the adenomyosis phenotype affects the proton nuclear magnetic resonance (1H-NMR)-based serum metabolic profile of patients. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 10, 2021 Category: Reproduction Medicine Authors: Mathilde Bourdon, Pietro Santulli, Fatiha Kateb, Khaled Pocate-Cheriet, Frederic Batteux, Chlo é Maignien, Sandrine Chouzenoux, Corinne Bordonne, Louis Marcellin, Gildas Bertho, Charles Chapron Tags: Original article Source Type: research

Hyaluronic acid –enriched transfer medium for frozen embryo transfer: a randomized, double-blind, controlled trial
To compare the effects of hyaluronic acid (HA) –enriched transfer medium versus standard medium on live birth rate after frozen embryo transfer (FET). (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 9, 2021 Category: Reproduction Medicine Authors: Sofie Shuk Fei Yung, Shui Fan Lai, Mei Ting Lam, Ellen Man Wa Lui, Jennifer Ka Yee Ko, Hang Wun Raymond Li, Jacki Yuk Ying Wong, Estella Yee Lan Lau, William Shu Biu Yeung, Ernest Hung Yu Ng Tags: Original article Source Type: research

Gonadotropin response to insulin and lipid infusion reproduces the reprometabolic syndrome of obesity in eumenorrheic lean women: a randomized crossover trial
To study the reprometabolic syndrome in normal-weight, eumenorrheic women by infusing a combination of insulin and lipid. Women with obesity have been shown to have reduced gonadotropins and impaired luteinizing hormone (LH) and follicle-stimulating hormone (FSH) response to gonadotropin-releasing hormone (GnRH). (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 8, 2021 Category: Reproduction Medicine Authors: Nanette Santoro, Irene E. Schauer, Katherine Kuhn, Angela J. Fought, Sara Babcock-Gilbert, Andrew P. Bradford Tags: Original article Source Type: research

Clinical use of indocyanine green during nerve-sparing surgery for deep endometriosis
To describe the anatomic and technical highlights of a novel nerve-sparing surgery in deep endometriosis (DE) using near-infrared (NIR) fluorescence technology and indocyanine green (ICG). (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 8, 2021 Category: Reproduction Medicine Authors: Kiyoshi Kanno, Kiyoshi Aiko, Shiori Yanai, Mari Sawada, Shintaro Sakate, Masaaki Andou Tags: Video Source Type: research

Thyroid function modifications in women undergoing controlled ovarian hyperstimulation for in  vitro fertilization: a systematic review and meta-analysis
To investigate the impact of controlled ovarian hyperstimulation (COH) for in  vitro fertilization (IVF) on thyroid function. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 7, 2021 Category: Reproduction Medicine Authors: Andrea Busnelli, Federico Cirillo, Paolo Emanuele Levi-Setti Tags: Original article Source Type: research

Guidance regarding gamete and embryo donation
This document provides the latest recommendations for the evaluation of potential sperm, oocyte, and embryo donors as well as their recipients, incorporating recent information about optimal screening and testing for sexually transmitted infections, genetic diseases, and psychological assessments. This revised document incorporates recent information from the US Centers for Disease Control and Prevention, US Food and Drug Administration, and American Association of Tissue Banks, which all programs offering gamete and embryo donation services must be thoroughly familiar with, and replaces the document titled “Recommen...
Source: Fertility and Sterility - April 7, 2021 Category: Reproduction Medicine Authors: Practice Committee of the American Society for Reproductive Medicine and the Practice Committee for the Society for Assisted Reproductive Technology Tags: ASRM pages Source Type: research

Guidance on qualifications for fertility counselors: a committee opinion
This guidance document was developed by the Mental Health Professional Group (MHPG) in partnership with the Practice Committee of the American Society for Reproductive Medicine (ASRM) to help determine the qualifications and training of mental health professionals working in reproductive medicine. This document replaces the document titled “ASRM Qualification Guidelines for Infertility,” last published in March 2015 and originally developed in 1995. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 7, 2021 Category: Reproduction Medicine Authors: Practice Committee and the Mental Health Professional Group of the American Society for Reproductive Medicine Tags: ASRM pages Source Type: research

Low feasibility of in  vitro matured oocytes originating from cumulus complexes found during ovarian tissue preparation at the moment of gender confirmation surgery and during testosterone treatment for fertility preservation in transgender men
To study the feasibility of in  vitro maturation of ovarian tissue oocytes for fertility preservation in transgender men on testosterone treatment. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 5, 2021 Category: Reproduction Medicine Authors: Sylvie Lierman, Annelies Tolpe, Ilse De Croo, Stefanie De Gheselle, Justine Defreyne, Machteld Baetens, Annelies Dheedene, Roos Colman, Bj örn Menten, Guy T’Sjoen, Petra De Sutter, Kelly Tilleman Tags: Original article Source Type: research

Diagnosis and treatment of luteal phase deficiency: a committee opinion
Luteal phase deficiency (LPD) is a clinical diagnosis associated with an abnormal luteal phase length of ≤10 days. Potential etiologies of LPD include inadequate progesterone duration, inadequate progesterone levels, or endometrial progesterone resistance. LPD has not only been described in association with medical conditions but also in fertile, normally menstruating women. Although progesterone is important for the process of implantation and early embryonic development, LPD has not been proven to be an independent entity causing infertility or recurrent pregnancy loss. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 4, 2021 Category: Reproduction Medicine Authors: Practice Committees of the American Society for Reproductive Medicine and the Society for Reproductive Endocrinology and Infertility Tags: ASRM pages Source Type: research

Body mass index is not associated with embryo ploidy in patients undergoing in  vitro fertilization with preimplantation genetic testing
To assess the association between body mass index (BMI) and embryo aneuploidy and mosaicism in a cohort of patients undergoing in  vitro fertilization (IVF) with trophectoderm biopsy for preimplantation genetic testing for aneuploidy (PGT-A) using next-generation sequencing technology. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 4, 2021 Category: Reproduction Medicine Authors: Yael R. Stovezky, Phillip A. Romanski, Pietro Bortoletto, Steven D. Spandorfer Tags: Original article Source Type: research

Guidance for using text, email, and video communication in practices devoted to reproductive medicine
The prevalence and ease of electronic communication, specifically email through patient portals associated with electronic medical records or via traditional enterprise email clients (e.g., Outlook) and video, have resulted in increased use for rapid communication between practitioners and their patients. Concerns regarding patient privacy and compliance with the regulations of the Health Insurance Portability and Accountability Act remain a barrier to routine incorporation of electronic communication into practice. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 3, 2021 Category: Reproduction Medicine Authors: Technology and Practice Committees of the American Society for Reproductive Medicine Tags: ASRM pages Source Type: research

A novel platform for discovery of differentially expressed microRNAs in patients with repeated implantation failure
To identify predictor microRNAs (miRNAs) from patients with repeated implantation failure (RIF). (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 3, 2021 Category: Reproduction Medicine Authors: Ching Hung Chen, Farn Lu, Wen Jui Yang, Pok Eric Yang, Wei Ming Chen, Shih Ting Kang, Yu Shan Huang, Yi Chi Kao, Chi Ting Feng, Po Chang Chang, Tiffany Wang, Chi An Hsieh, Yu Chun Lin, Jack Yu Jen Huang, Lily Hui-Ching Wang Tags: Original article Source Type: research

Fertility treatments and breast cancer risk in Jewish Israeli BRCA mutation carriers
To determine whether fertility treatments impact the risk of breast cancer in Jewish Israeli BRCA1/2 mutation carriers. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 3, 2021 Category: Reproduction Medicine Authors: Tamar Perri, Shani Naor-Revel, Perry Eliassi-Revivo, Dror Lifshitz, Eitan Friedman, Jacob Korach Tags: Original article Source Type: research

Pretreatment antim üllerian hormone levels and outcomes of ovarian stimulation with gonadotropins/intrauterine insemination cycles
To evaluate the association, if any, between serum antim üllerian hormone (AMH) levels and probability of clinical pregnancy and spontaneous abortion (SAB) in the infertility setting. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 3, 2021 Category: Reproduction Medicine Authors: Stylianos Vagios, Jennifer Y. Hsu, Caitlin R. Sacha, Irene Dimitriadis, Georgios Christou, Kaitlyn E. James, Charles L. Bormann, Irene Souter Tags: Original article Source Type: research

An unexpected connection: getting to know uteroperitoneal fistulas
Uteroperitoneal fistulas are anomalous connections between the uterus and peritoneal cavity usually resulting from gynecologic surgery or other pathology that leads to ischemia and poor healing. The true incidence is unknown as they are extremely rare with just over 15 cases reported in the medical literature (1). Most frequently, these fistulas are seen anteriorly after cesarean delivery due to inadequate healing but have also been reported with surgical termination of pregnancy, myomectomy, and salpingectomy. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 3, 2021 Category: Reproduction Medicine Authors: Michael F. Neblett, Zaraq Khan Tags: Reflections Source Type: research

Trust science?
Fact or fiction? Science or theory? Truth or lies? Who determines what is a fact, scientifically proven, or truth? This question has been at the center of our current events over the past year. However, the question also comes to mind when reading the May 1971 issue of Fertility and Sterility. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 3, 2021 Category: Reproduction Medicine Authors: Olivia Carpinello, Alan DeCherney Tags: Fertility and Sterility: 50 years ago today Source Type: research

In  vitro growth and maturation of primordial follicles and immature oocytes
Cryopreservation of ovarian tissue to preserve the fertility of girls and young women at high risk of sterility is now widely practiced. Pieces of cryopreserved ovarian cortex can be thawed and autografted to restore fertility, but because of the risks of reintroduction of the cancer, transplantation may not be possible for girls and women with blood-borne leukemias or cancers with a high risk of ovarian metastasis. Cryopreserved ovarian tissue contains mainly primordial follicles but also provides access to immature oocytes from small antral follicles, which may be matured in  vitro to provide an additional source of...
Source: Fertility and Sterility - April 3, 2021 Category: Reproduction Medicine Authors: Evelyn E. Telfer, Claus Yding Andersen Tags: Views and reviews Source Type: research

Resection of a uterine septum in a normal uterus: Whoa Nellie
“L’histoire, c’est du vrai qui devient faux.Le mythe, c’est du faux qui devient vrai.”(History is true that becomes false.The myth is a falsehood that becomes true.)—Jean Cocteau (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 3, 2021 Category: Reproduction Medicine Authors: Artur Ludwin, Mark P. Trolice, Bala Bhagavath, Steven R. Lindheim Tags: Inklings Source Type: research

Conception by fertility treatment and offspring deoxyribonucleic acid methylation
To investigate whether deoxyribonucleic acid (DNA) methylation at birth and in childhood differ by conception using assisted reproductive technologies (ART) or ovulation induction compared with those in children conceived without fertility treatment. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 3, 2021 Category: Reproduction Medicine Authors: Edwina H. Yeung, Pauline Mendola, Rajeshwari Sundaram, Xuehuo Zeng, Weihua Guan, Michael Y. Tsai, Sonia L. Robinson, Judy E. Stern, Akhgar Ghassabian, David Lawrence, Thomas G. O ’Connor, James Segars, Robert E. Gore-Langton, Erin M. Bell Tags: Original article Source Type: research

Antibiotics before frozen embryo transfer: treating the patient or the physician?
Specialists in the field of reproductive medicine are consistently striving to improve pregnancy outcomes of in  vitro fertilization (IVF), and they aim to achieve this goal by following evidence-based recommendations. However, when evidence is limited, there can be an inclination to perform interventions during IVF that “might help and won’t hurt.” There may be a tendency to consider such adjuvant the rapies when preparing for and performing embryo transfer (ET) because of the high stakes associated with this part of the IVF process. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 3, 2021 Category: Reproduction Medicine Authors: Marissa L. Bonus, Christina Boots, Lia A. Bernardi Tags: Reflections Source Type: research

Fertility preservation in men and women: Where are we in 2021? — Are we rising to the challenge?
Demand for fertility preservation in women for oncologic, nononcologic, and personal reasons has increased dramatically. Meeting that demand is a major challenge, and we are rising to the challenge. Mature oocyte cryopreservation after ovarian stimulation and ovarian tissue cryopreservation are both methods endorsed by the American Society for Reproductive Medicine (formerly The American Fertility Society), and numerous papers confirmed their efficacy. In girls and women with leukemia or cancers who are at a high risk of ovarian metastasis and who may not be eligible for ovarian tissue transplantation, restoration of ferti...
Source: Fertility and Sterility - April 3, 2021 Category: Reproduction Medicine Authors: Jacques Donnez, Marie-Madeleine Dolmans Tags: Views and reviews Source Type: research

Best time for frozen embryo transfer? There ’s no time like the present
In  vitro fertilization with frozen embryo transfer (FET) has become increasingly common due to advances in cryopreservation techniques, reassuring safety data, and increasing evidence that FET may lead to more favorable perinatal and live birth outcomes compared with fresh embryo transfer. Thus, the “freeze-all strategy,” i.e., selectively freezing all embryos and performing FET later, has become a popular choice. However, there is limited evidence available regarding the ideal timing for subsequent FET. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 2, 2021 Category: Reproduction Medicine Authors: Jawaria Amir, Jennifer Hirshfeld-Cytron Tags: Reflections Source Type: research

Development of an emergency plan for in  vitro fertilization programs: a committee opinion
All in vitro fertilization programs and clinics should have a plan to protect fresh and cryopreserved human specimens (embryos, oocytes, sperm) and to provide contingencies for continuation or cessation of patient care in the event of an emergency or natural disaster. This document replaces the document titled “Recommendations for development of an emergency plan for in vitro fertilization programs: a committee opinion,” last published in 2016 (Fertil Steril 2016;105:e11–3). (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 1, 2021 Category: Reproduction Medicine Authors: Practice Committees of the American Society for Reproductive Medicine, the Society for Assisted Reproductive Technology, and the Society of Reproductive Biologists and Technologists Tags: ASRM Pages Source Type: research

Validation of a highly realistic embryo transfer simulator and trainer
Establishment of a pregnancy by assisted reproduction requires a successful embryo transfer. Although embryo implantation after transfer does not happen in all cases, even in the hands of the most highly skilled providers, data suggest that a lower implantation rate may result following embryo transfers by less skilled providers. Thus, optimal pregnancy outcomes after embryo transfer require highly skilled providers. For this reason, it is critical that trainees are provided with opportunities to finely hone and develop robust embryo transfer skills. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 1, 2021 Category: Reproduction Medicine Authors: James Segars, Michael A. Thomas Tags: Reflections Source Type: research

Human immunodeficiency virus and infertility treatment: an Ethics Committee opinion
Human Immunodeficiency Virus is a serious but manageable chronic disease that affects persons of reproductive age, many of whom express a desire for biological parenthood. This document is a revision of the original document of the same name, last published in 2015 (Fertil Steril 2015;104:e1 –8). (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 1, 2021 Category: Reproduction Medicine Authors: Ethics Committee of the American Society for Reproductive Medicine Tags: ASRM pages Source Type: research

In  vitro fertilization oocyte retrieval: to “flush” or not?
The use of follicle “flushing” during transvaginal oocyte retrieval in in vitro fertilization (IVF) has been debated for many years. The theoretical advantage of using a double-lumen retrieval needle to aspirate the follicular fluid is that this process should “flush” out the oocyte and optimize oocyte retriev al yield (oocytes retrieved divided by follicles aspirated) when compared with direct follicle aspiration. There are now multiple randomized controlled trials in the scientific literature, which can help us objectively analyze the current data and come to some conclusions. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 1, 2021 Category: Reproduction Medicine Authors: Humberto Scoccia Tags: Reflections Source Type: research

Insufficient fertility counseling and decisional regret: a call to raise our standards for fertility preservation counseling prior to gender-affirming care
With increasing insurance coverage, societal visibility, and acceptance of gender-affirming treatments, more transgender and non-binary (TGNB) individuals are seeking care. As population surveys show rising numbers of high school age individuals identifying as TGNB, more people will be receiving gender-affirming care before considering or completing family building. Health care providers, including fertility specialists, need to be able to counsel these patients accurately and sensitively about the possible reproductive consequences and the available options for fertility preservation. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 1, 2021 Category: Reproduction Medicine Authors: Amanda R. Schwartz, Molly B. Moravek Tags: Reflections Source Type: research

Resveratrol improves granulosa cell activity through mitochondrial biogenesis
Granulosa cells (GC) support the developing oocyte from its earliest primordial follicle stage, playing an essential role in oocyte maturation and human reproduction. These important cells provide energy for oocyte follicular maturation through carbohydrate, lipid, and protein metabolism (1). The energy needed by the oocyte is provided in the form of adenosine triphosphate, which is produced in the granulosa cell mitochondria and passed to the oocyte via gap junctions. Hence, the mitochondria serve a critical role in energy production for the growing oocyte. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 1, 2021 Category: Reproduction Medicine Authors: Kathryn J. Grive, May-Tal Sauerbrun-Cutler Tags: Reflections Source Type: research

Endometrial receptivity screening in the general assisted reproductive technology population
The article by Riestenberg et  al. (1) details a prospective cohort study assessing the value of the endometrial receptivity assay (ERA) in screening a general assisted reproductive technology (ART) population. This is an important contemporary question as clinicians seek to optimize every aspect of the ART process to enhance t heir patient’s outcomes. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 1, 2021 Category: Reproduction Medicine Authors: Richard T. Scott Tags: Reflections Source Type: research

The promised land of individualized ovarian stimulation: Are we there yet?
Over the past decade, the merits of individualized ovarian stimulation protocols for in  vitro fertilization (IVF) using validated dosing algorithms have become increasingly evident. A 2016 American Society for Reproductive Medicine Practice Committee guideline identified factors such as polycystic ovarian syndrome, elevated antimüllerian hormone levels, and peak estradiol levels, wh ich would place patients at increased risk for ovarian hyperstimulation syndrome (OHSS). This guideline also recognized the need for adjustment of ovarian stimulation protocols to mitigate these risks (1). (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 1, 2021 Category: Reproduction Medicine Authors: Helen H. Kim, Sedona E. Speedy Tags: Reflections Source Type: research

Using pharmacologic research to efficiently meet acute contraceptive needs
Before the Covid-19 pandemic, reproductive health professionals had already determined that many patients wished for contraception with the ease of a long-acting reversible method, such as intrauterine and subdermal devices, but without the long-term commitment and the need to return to a healthcare provider for discontinuation. The current global pandemic has highlighted this need (1). More women than ever have been unable to access basic healthcare, including contraception, because of Covid-19 restrictions or loss of insurance as a result of unemployment. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 1, 2021 Category: Reproduction Medicine Authors: Aaron Lazorwitz, Stephanie Teal Tags: Reflections Source Type: research

Circulating cytokines during the blastocyst peri-implantation period
Human reproduction is an inefficient process, primarily because of frequent aneuploidy, but also because the maternal-fetal interface requires an immune homeostasis with precise conditions to enable pregnancy. Classical immune studies of peripheral blood had suggested that maternal immunosuppression is required to tolerate the presence of an allogeneic fetus. Although this theory was inspired by solid organ transplantation studies, it is now understood that the immunology of transplantation and that of pregnancy are quite different. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 1, 2021 Category: Reproduction Medicine Authors: Maria J. de los Santos, Diana Alecsandru Tags: Reflections Source Type: research

Live and let DIE: a closer look at deep infiltrating endometriosis
Endometriosis has long been a challenging diagnosis; its evaluation, treatment, and prognosis have evolved with improvement in medical management and surgical techniques. This common, benign disorder may affect up to 50% of women with infertility or pelvic pain. In addition, specific types of endometriosis may have varying presentations and implications. For example, in the case of deep endometriosis, operative management may be difficult because of infiltrative lesions that can involve pelvic structures such as the ureters, bowel, or bladder. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 1, 2021 Category: Reproduction Medicine Authors: Vaishnavi Purusothaman, Audrey S. Garneau, Linnea R. Goodman Tags: Reflections Source Type: research

Editorial Board
(Source: Fertility and Sterility)
Source: Fertility and Sterility - April 1, 2021 Category: Reproduction Medicine Source Type: research

Table of Contents
(Source: Fertility and Sterility)
Source: Fertility and Sterility - April 1, 2021 Category: Reproduction Medicine Source Type: research

Medroxyprogesterone acetate is a useful alternative to a gonadotropin-releasing hormone antagonist in oocyte donation: a randomized, controlled trial
To compare ovarian response and reproductive outcomes in oocyte donors undergoing pituitary suppression with medroxyprogesterone acetate (MPA) versus those undergoing conventional treatment with a gonadotropin-releasing hormone (GnRH) antagonist. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 1, 2021 Category: Reproduction Medicine Authors: Juan Giles, Pilar Alama, Pilar Gamiz, Carmen Vidal, Paloma Badia, Antonio Pellicer, Ernesto Bosch Tags: Original article Source Type: research

Validation study of the Access AMH antim üllerian hormone assay for the prediction of poor ovarian response to controlled ovarian stimulation
To evaluate the diagnostic performance of the antim üllerian hormone (AMH) level determined using the Access AMH assay for predicting poor ovarian response (POR) defined as ≤4 oocytes retrieved, including the validation of the predefined AMH cutoff of 0.93 ng/mL in both serum and plasma. (Source: Fertility and Sterility)
Source: Fertility and Sterility - March 31, 2021 Category: Reproduction Medicine Authors: Valerie L. Baker, Michael J. Glassner, Kevin Doody, Vicki L. Schnell, Clarisa Gracia, Sanghyuk S. Shin, Millie A. Behera, C écile Maria Le Saint, Michael M. Alper, Mary Ellen Pavone, Edward A. Zbella, Charles C. Coddington, Lorna A. Marshall, Ronald F. F Tags: Original article Source Type: research

Endometrial thickness is not predictive for live birth after embryo transfer, even without a cutoff
To investigate the predictive value of endometrial thickness (EMT) for live birth when a lower threshold of EMT is not employed for embryo transfer (ET). (Source: Fertility and Sterility)
Source: Fertility and Sterility - March 31, 2021 Category: Reproduction Medicine Authors: Bahar Shakerian, Engin Turkgeldi, Sule Yildiz, Ipek Keles, Baris Ata Tags: Original article Source Type: research

Perinatal outcomes in singleton pregnancies after in  vitro fertilization cycles over 24 years
To determine how a shift in clinical practice along with laboratory changes has impacted singleton perinatal outcomes after autologous in  vitro fertilization (IVF) cycles. (Source: Fertility and Sterility)
Source: Fertility and Sterility - March 30, 2021 Category: Reproduction Medicine Authors: Jaimin S. Shah, Denis A. Vaughan, Angela Leung, Ann Korkidakis, Francesc Figueras, Desiree Garcia, Alan S. Penzias, Denny Sakkas Tags: Original article Source Type: research