The diagnostic potential of whole exome sequencing in infertile men due to sperm production defect
Male factor infertility is an important clinical problem whose most severe phenotype, severe oligospermia or azoospermia, has a variety of genetic causes. Some, like Klinefelter syndrome or cystic fibrosis, are well understood, but most are still unknown, and Y chromosome microdeletions only explain a fraction of the remaining cases. In consanguineous and nonconsanguineous families, whole exome sequencing (WES) has been successfully used to identify likely causal mutations in severe oligospermia (1, 2). (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 20, 2020 Category: Reproduction Medicine Authors: Willy J. Chertman, Ranjith Ramasamy Tags: Reflections Source Type: research

Harnessing the full potential of reproductive genetics and epigenetics for male infertility in the era of “big data”
The complexity of male reproductive impairment has hampered characterization of the underlying genetic causes of male infertility. However, in the last 20 years, more powerful and affordable tools to interrogate the genetic and epigenetic determinants of male infertility have accelerated the number of new discoveries in the characterization of male infertility. With this explosion of new data, integration in a systems-based approach —including complete phenotypic information—to male infertility is imperative. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 20, 2020 Category: Reproduction Medicine Authors: Darshan P. Patel, Tim G. Jenkins, Kenneth I. Aston, Jingtao Guo, Alexander W. Pastuszak, Heidi A. Hanson, James M. Hotaling Tags: Views and reviews Source Type: research

New insights to guide patient care: the bidirectional relationship between male infertility and male health
Male reproduction is a complex process, and numerous medical conditions have the potential to alter spermatogenesis. In addition, male factor infertility may be a biomarker for future health. In the present review, we discuss the current literature regarding the association between systemic diseases and fertility, which may impact clinical outcomes or semen parameters. A number of conditions that have systemic consequences were identified, including genetic (e.g., cystic fibrosis, DNA mismatch repair alterations), obesity, psychological stress, exogenous testosterone, and a variety of common medications. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 20, 2020 Category: Reproduction Medicine Authors: Alex M. Kasman, Francesco Del Giudice, Michael L. Eisenberg Tags: Views and reviews Source Type: research

Operative hysteroscopy should be repeated as many times as necessary for the treatment of refractory Asherman syndrome versus is there any alternative therapy worth considering?
Asherman syndrome (AS) is an acquired condition defined by the presence of intrauterine adhesions (IUAs) that result when the bona fide endometrium is replaced by fibrotic tissues. IUAs provoke symptoms such as menstrual abnormalities, pelvic pain, recurrent miscarriage, infertility, abnormal placentation, and attendant psychological distress (1). The destruction of healthy endometrium arises from multiple factors that affect the endometrial stem cell niche and create IUAs. The most common is curettage of the pregnant uterus after delivery of miscarriage. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 20, 2020 Category: Reproduction Medicine Authors: Carlos Simon Tags: Fertile battle Source Type: research

Mortality from infancy to adolescence in singleton children conceived from assisted reproductive techniques versus  naturally conceived singletons in Sweden
To assess infant ( (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 18, 2020 Category: Reproduction Medicine Authors: Kenny A. Rodriguez-Wallberg, Frida E. Lundberg, Sara Ekberg, Anna L.V. Johansson, Jonas F. Ludvigsson, Catarina Almqvist, Sven Cnattingius, Anastasia N. Iliadou Tags: Original article Source Type: research

Comparison of endometrial prostanoid profiles in three infertile subgroups: the missing part of receptivity?
To study the prostanoid profile of the endometria of patients with recurrent implantation failure (RIF), unexplained infertility (UIF), and recurrent miscarriages (RM), and to compare them with the endometria of healthy fertile controls. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 12, 2020 Category: Reproduction Medicine Authors: Irem Demiral Kele ş, Ege Ülgen, Melike Belkız Erkan, Saliha Esin Çelik, Yasemin Aydın, Ayşe Nur Önem, Hülya Kandemir, Tuğçe Arslanoğlu, Mustafa Reşat Apak, Uğur Sezerman, John Yeh, Faruk Buyru, Ercan Baştu Tags: Original article Source Type: research

Progesterone is a physiological trigger of ovulatory gonadotropins
The process of ovulation in the human is central not only to the field of infertility, but to obstetrics and gynecology in general, and has been a subject of thousands of research projects for more than a century. The holy grail of ovulation is the mechanism triggering the surge of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which according to the current paradigm is caused by a critically timed, sustained elevation of estradiol that culminates in the end of the follicular phase of the menstrual cycle. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 11, 2020 Category: Reproduction Medicine Authors: Dmitri Dozortsev, Antonio Pellicer, Michael P. Diamond Tags: Inklings Source Type: research

Embryo ’s Natural Motion (enMotion): a paired randomized controlled trial evaluating a dynamic embryo culture system
To determine if a dynamic embryo culture system affects the reproductive potential of human embryos resulting from in  vitro fertilization (IVF). (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 7, 2020 Category: Reproduction Medicine Authors: Caroline R. Juneau, Ashley W. Tiegs, Jason M. Franasiak, Linnea R. Goodman, Christine Whitehead, George Patounakis, Richard T. Scott Tags: Original article Source Type: research

Influence of subfertility and assisted reproductive technology treatment on mortality of women after delivery
To compare incidence, risk factors, and etiology of women ’s deaths in fertile, subfertile, and undergoing assisted reproductive technology (ART) in the years after delivery. (Source: Fertility and Sterility)
Source: Fertility and Sterility - February 7, 2020 Category: Reproduction Medicine Authors: Charles C. Coddington, Daksha Gopal, Xiaohui Cui, Howard Cabral, Hafsatou Diop, Judy E. Stern Tags: Original article Source Type: research

High antim üllerian hormone levels are associated with preterm delivery in patients with polycystic ovary syndrome
Antim üllerian hormone (AMH) levels are higher in patients with polycystic ovary syndrome (PCOS). Accumulating evidence indicates that AMH has an impact on the physiology of the female reproductive system. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 20, 2020 Category: Reproduction Medicine Authors: Kai-Lun Hu, Fen-Ting Liu, Huiyu Xu, Rong Li, Jie Qiao Tags: Original article Source Type: research

Prognostic role of preimplantation genetic testing for aneuploidy in medically indicated fertility preservation
To investigate the use of preimplantation genetic testing for aneuploidy (PGT-A) among patients pursuing embryo banking (EB) for medically indicated fertility preservation (FP). (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 20, 2020 Category: Reproduction Medicine Authors: Jennifer K. Blakemore, Emma C. Trawick, James A. Grifo, Kara N. Goldman Tags: Original article Source Type: research

Gonadotropins versus oral ovarian stimulation agents for unexplained infertility: a systematic review and meta-analysis
To compare live birth and multiple gestation in patients diagnosed with unexplained infertility undergoing intrauterine insemination after ovarian stimulation (OS-IUI) with oral medications versus gonadotropins. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 20, 2020 Category: Reproduction Medicine Authors: Jessica R. Zolton, Peter G. Lindner, Nancy Terry, Alan H. DeCherney, Micah J. Hill Tags: Original article Source Type: research

In  vitro fertilization in underweight women: focus on obstetric outcome
Cutoff values for abnormal body weight, usually estimated by body mass index (BMI), have been established in medical practice to detect associated metabolic and endocrine alterations responsible for the increased risk of developing a range of health-impairing conditions among underweight and overweight individuals. According to recent statistics by the World Health Organization (1), in developed societies excess body weight (overweight or obesity) constitutes an increasingly common status involving 50% –70% of the adult population. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 20, 2020 Category: Reproduction Medicine Authors: Jos é Bellver Tags: Reflections Source Type: research

Oocytes of women who are obese or overweight have lower levels of n-3 polyunsaturated fatty acids compared with oocytes of women with normal weight
To ascertain whether the oocytes of women who are obese or overweight have a different fatty acid (FA) profile than women with normal weight. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Authors: Roberto Matorras, Antonia Exposito, Marcos Ferrando, Rosario Mendoza, Zaloa Larreategui, Luc ía Laínz, Larraitz Aranburu, Fernando Andrade, Luis Aldámiz-Echevarria, Maria Begoña Ruiz-Larrea, Jose Ignacio Ruiz-Sanz Tags: Seminal contribution Source Type: research

Ultrasonographically determined size of seminiferous tubules predicts sperm retrieval by microdissection testicular sperm extraction in men with nonobstructive azoospermia
To investigate the value of the ultrasonographically determined size of seminiferous tubules and other conventional parameters for predicting sperm retrieval by microdissection testicular sperm extraction (micro-TESE). (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Authors: Shoichi Nariyoshi, Kazuma Nakano, Gen Sukegawa, Takehiko Sho, Yuji Tsuji Tags: Original article Source Type: research

Steroid hormones and hormone antagonists regulate the neural marker neurotrimin in uterine leiomyoma
To characterize the role of steroid hormone and antihormone exposure on neurotrimin (NTM) expression in human leiomyoma and myometrial tissue and cells. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Authors: Toral P. Parikh, Minnie Malik, Joy Britten, Jasmine M. Aly, Justin Pilgrim, William H. Catherino Tags: Original article Source Type: research

Use of exogenous gonadotropins for ovulation induction in anovulatory women: a committee opinion
This document reviews gonadotropin treatment for ovulation induction in anovulatory women and outlines the recommended pretreatment evaluation, indications, treatment regimens, and complications of gonadotropin treatment. It replaces the document with a similar name, last published in 2008 (Fertil Steril 2008;90:S7-12). (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Authors: Practice Committees of the American Society for Reproductive Medicine and Society for Reproductive Endocrinology and Infertility Tags: ASRM pages Source Type: research

Oocytes, obesity, and omega-3 fatty acids
Fatty acids are vital dietary sources of energy for humans and are also important structural components of cells. The well-known omega-3 fatty acids, also known as n-3 fatty acids, are not made in enough quantities in the body and therefore need to be acquired from dietary sources making them essential fatty acids. In general, n-3 fatty acids have been shown to improve conditions such as psychiatric disease, heart disease, metabolic syndrome, ADHD, fetal brain development, autoimmune disease, and cancer. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Authors: Maya Barsky, Chellakkan S. Blesson Tags: Reflections Source Type: research

Neurotrimin: a novel neural cell adhesion molecule correlating with uterine fibroid phenotype
Uterine fibroids (UFs), also known as leiomyomas, are benign pelvic tumors that occur in nearly 70% of all reproductive-aged women (1, 2). Some of these women will develop severe symptoms associated with the presence of these tumors. Annually, UFs account for over 200,000 hysterectomies in the U.S. This is due to the lack of long-term effective medical therapies (3). Tumor growth is characterized by slow proliferation with increased deposition of extracellular matrix (proteoglycans and collagens), which participates in the fibrotic phenotype of UFs (3). (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Authors: Hajra Takala, Ayman Al-Hendy, Qiwei Yang Tags: Reflections Source Type: research

Aneuploidy through the looking glass
Although blastocyst-stage preimplantation genetic testing for aneuploidy (PGT-A) has been shown to improve implantation rates and enables near-universal single embryo transfer, it still requires an invasive biopsy and cryopreservation to allow time for genetic analysis (1). Recently there has been a renewed effort toward developing non-invasive methods for predicting aneuploidy. For example, various methodologies have been employed to improve non-invasive chromosome screening by amplifying DNA from the culture media. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Authors: Eric J. Forman Tags: Reflections Source Type: research

Metformin, rosiglitazone, or both for obese women with polycystic ovary syndrome?
In this issue, Yujing et  al. (1) compared the effects of the two most commonly used insulin sensitizers for obese, insulin resistant women with polycystic ovary syndrome (PCOS; by Rotterdam criteria). Two hundred four participants were randomized into three comparable groups. Group 1 received 1,500 mg metformin, group 2 r eceived 4 mg of rosiglitazone, and group 3 received 1000 mg metformin plus 4 mg rosiglitazone for six months. In addition to drugs, dietary adjustment and moderate-strength physical exercises for 40 minutes three times a week were recommended to all groups. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Authors: Sushila Arya, Karl R. Hansen, Robert A. Wild Tags: Reflections Source Type: research

The excessive presence (percentage or number) of endometrial immune cells in patients with chronic endometritis cannot be associated with reduced endometrial receptivity or recurrent pregnancy failure
In their study, Li et  al. (1) analyzed immune cells in peripheral blood and endometrial tissue samples from patients with recurrent reproductive failure (recurrent miscarriage [RM]/implantation failure [RIF]). They observed an increased percentage of CD68+ macrophage, CD8+ T cells, and Foxp3+ Treg cells in the endometr ium of patients with chronic endometritis (CE) compared with non-CE. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Authors: Diana Alecsandru, Juan A. Garcia Velasco Tags: Reflections Source Type: research

Compassionate transfer: patient requests for embryo transfer for nonreproductive purposes
A patient request to transfer embryos into her body in a location or at a time when pregnancy is highly unlikely to occur is deemed a request for “compassionate transfer” and often reflects the patient’s deeply personal, strongly held preferences and values. It is ethically permissive for physicians to honor or decline such requests if they do so in a nondiscriminatory manner. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Authors: Ethics Committee of the American Society for Reproductive Medicine Tags: ASRM pages Source Type: research

Vitamin D and uterine fibroids: preclinical evidence is in; time for an overdue clinical study!
Uterine fibroids (UFs; leiomyoma) are the most common benign neoplastic threat that arise in the myometrium of women of reproductive age. These monoclonal tumors occur in about 77% of women by the age of 50 years and are clinically manifest in 25% –50% of women. Although benign, nonetheless these tumors are associated with significant morbidity including abnormal uterine bleeding, anemia, pelvic pain, subfertility, and obstetric complications. In addition, they are the primary indication for hysterectomy, and a major source of reproductive dysfunction. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Authors: Mohamed Ali, Lillian Prince, Ayman Al-Hendy Tags: Reflections Source Type: research

What ’s conceivable: the complexities of human parental desire
In recent years transgender people have gained increased visibility in the public sphere, and increased access to healthcare services, including gender-affirming hormones and surgeries. Alongside with these advances, healthcare providers and researchers are giving more attention to the long-term effects of gender-affirming care. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Authors: Molly B. Moravek, Daphna Stroumsa Tags: Reflections Source Type: research

(D)evolving attitudes toward late onset hypogonadism
Although chemotherapy is no complete substitute for psychotherapy in the treatment of impotence of the male patient, nevertheless, in cases where psychologic and/or somatic failure plays a role as etiologic agent then indeed chemotherapy is indicated. —T. Jakobovits (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Authors: Martin Kathrins Tags: Fertility and Sterility: 50 years ago today Source Type: research

Telomere length and its assessment for female reproduction
The award of the 2009 Nobel Prize for Physiology and Medicine to Blackburn, Greider, and Szostak recognized the importance of their contribution from the 1980s onward on the biology and significance of telomeres and telomerase. This work provided insight into a fundamental cellular mechanism by identifying the chromosome capping role of the repeating deoxyribonuclease (DNA) sequences that constitute the telomere for the accurate control of DNA replication. The importance of telomere shortening with repeated cycles of DNA replication and the role of telomerase in rebuilding telomere length became of considerable interest wi...
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Authors: David H. Barlow Tags: Reflections Source Type: research

Primary dysmenorrhea: new dose of an old medicine offers more options
During the past decade, there have been few advances in the treatment of primary dysmenorrhea. Although the basic pathophysiology for primary dysmenorrhea seems well-understood, pharmacologic development appears to have lagged behind. The first tier treatments, nonsteroidal anti-inflammatories and hormonal contraceptives, are the same at present as they were in the 1970s (1). In fact, the newest treatment options for primary dysmenorrhea are a piggy-back on the pharmacologic developments for contraception and endometriosis, namely the levonorgestrel intrauterine device and the growth hormone-releasing hormone antagonist. (...
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Authors: Amanda C. Yunker Tags: Reflections Source Type: research

DuoStim: a new strategy proposed for women with poor ovarian response
Poor ovarian response (POR) to stimulation is one of the most difficult conditions in in  vitro fertilization (IVF) cycles, as it is well established that the cumulative live birth rate is positively associated with the number of oocytes obtained. Although many strategies have been proposed to treat this population with a poor prognosis, there is no clear superiority of one treatment v ersus another to obtain more oocytes or, even more important, to obtain a higher live birth rate (LBR). Thanks to experience in the stimulation of patients for urgent fertility preservation (e.g., due to the diagnosis of cancer), luteal...
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Authors: Elena Labarta Tags: Reflections Source Type: research

Erratum
In the article by Pokrzywinski, et  al., “Impact of elagolix on work loss due to endometriosis-associated pain: estimates based on the results of two phase III clinical trials” (Fertil Steril 2019;112:545-51), author Soliman’s disclosures were incorrectly listed. They should read A.M.S. is an employee of and owns stock/stock o ptions in AbbVie. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Tags: Erratum Source Type: research

Endometrial thickness as an independent risk factor for ectopic pregnancy in in  vitro fertilization: should we change our counseling and practice?
In this issue of Fertility and Sterility, Liu et  al. (1) analyzed the effect of endometrial thickness (EMT) on ectopic pregnancy rate in frozen embryo transfer (FET) cycles. Ectopic pregnancy (EP) is an undesired outcome of in vitro fertilization (IVF) cycles and has significant medical, emotional and financial implications for the patients. La rge studies that have analyzed more than 10 years of data in United Kingdom and United States show that the risk of ectopic pregnancy associated with IVF is 1.5% to 2%, and it has decreased over time (2, 3). (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Authors: Elnur Babayev, Jared C. Robins Tags: Reflections Source Type: research

Rare disorders of penile erection
This literature review presents two unusual and mystifying disorders of penile erection: painful nocturnal erections, alternatively termed sleep-related painful erections, and idiopathic stuttering priapism, a variant of recurrent ischemic priapism in which no cause is discernible. The disorders are closely related although they are distinct clinically and pathologically. The main subject areas of discussion are recognition, clinical evaluation and management although current concepts surrounding their causes and mechanisms are also addressed. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Authors: Arthur L. Burnett Tags: Views and reviews Source Type: research

Use of the progestin challenge test in diagnosing amenorrhea: the time has come to say goodbye
The evaluation of amenorrhea, whether primary or secondary, has long been inconsistent, confused, or both for many practitioners. As we consider diagnostic paradigms commonly pursued today, it is useful to consider the genesis as well as the longstanding applicability and value of the commonly employed progestin challenge test. To our knowledge, the progestin challenge test became a widely used and standard diagnostic test following publication of a textbook, Clinical Gynecologic Endocrinology and Infertility, by Drs. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Authors: William D. Schlaff, Charles C. Coddington Tags: Inklings Source Type: research

Post-orgasmic illness syndrome: history and current perspectives
Post-orgasmic illness syndrome is a rare disorder causing a debilitating cluster of flu-like and allergic type symptoms that occur within seconds, minutes or hours after ejaculation. Symptoms occur after intercourse, masturbation or spontaneous ejaculation and last from 2 to 7 days. The condition is chronic and follows a primary pattern occurring in adolescence and a secondary acquired pattern with onset later in life. The true incidence is unknown as the condition is likely under-reported and under-diagnosed. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Authors: Mark R. Paulos, Gabriella J. Avelliino Tags: Views and reviews Source Type: research

Understand low-quality evidence: learn from food chains
Bioaccumulation refers to the accumulation process of toxic substances through food chains. Species on top of food chains are the most severely affected ones. Such a principle is also applicable in evidence-based medicine. Evidence from systematic reviews is considered the top of the pyramid in evidence-based medicine. However, the quality of the evidence from systematic reviews relies on the quality of evidence from the primary randomized controlled trials (RCTs). Bias and other concerns in the primary RCTs, as well as the evidence synthesis process, will affect the validity of results in subsequent systematic reviews. (S...
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Authors: Rui Wang, Madelon van Wely Tags: Reflections Source Type: research

Genital manifestations of body dysmorphic disorder in men: a review
Body dysmorphic disorder (BDD) is a serious psychiatric condition that affects approximately 2.5% of the U.S. adult population. BDD occurs when a person develops a debilitating focus and sense of distress about a minor or imagined physical flaw. There is growing awareness that in some men with BDD, the physical preoccupation centers on the appearance of their genitals. This review explores existing research on genital manifestations of BDD in men. PubMed and PsychInfo searches with the key word ’s genital manifestations of BDD were conducted, which yielded a list of 48 unique articles. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Authors: Abigail K. Mansfield Tags: Views and reviews Source Type: research

Post-finasteride syndrome: a surmountable challenge for clinicians
Post-finasteride syndrome (PFS) is a constellation of serious adverse side effects manifested in clinical symptoms that develop and persist in patients during and/or after discontinuing finasteride treatment in men with pattern hair loss (androgenetic alopecia) or benign prostatic hyperplasia. These serious adverse side effects include persistent or irreversible sexual, neurological, physical and mental side effects. To date, there are no evidence-based effective treatments for PFS. Although increasing number of men report persistent side effects, the medical community has yet to recognize this syndrome nor are there any s...
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Authors: Abdulmaged M. Traish Tags: Views and reviews Source Type: research

Introduction
There are conditions that are rare and that most providers are unaware of or conditions that consist of a series of symptoms for which there is no agreement that they are even a medical condition. These include painful nocturnal erections, post-orgasmic illness syndrome, body dysmorphic disorder, and post-finasteride syndrome. While some have a psychiatric basis, others clearly have an organic pathophysiology, while for others, there remains much controversy. This month ’s Views and Reviews will inform the reader of these conditions so they may recognize affected patients and direct them towards appropriate resources...
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Authors: Mark Sigman Tags: Views and reviews Source Type: research

Editorial Board
(Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Source Type: research

Table of Contents
(Source: Fertility and Sterility)
Source: Fertility and Sterility - January 1, 2020 Category: Reproduction Medicine Source Type: research

A step towards the automation of intracytoplasmic sperm injection: real time confirmation of mouse and human oocyte penetration and viability by electrical resistance measurement
To evaluate if oocyte penetration and viability can be confirmed by an electrical resistance increase. Automated (robotic) intracytoplasmic sperm injection (ICSI) requires confirmation of oolemma penetration before sperm injection. Visual assessment using image processing algorithms have been developed but remain unreliable. We hypothesized that an increase in electrical resistance upon oolemma piercing during ICSI can serve as an objective tool to confirm oocyte penetration and viability. (Source: Fertility and Sterility)
Source: Fertility and Sterility - December 26, 2019 Category: Reproduction Medicine Authors: Amir Mor, Man Zhang, Ecem Esencan, Burcin Simsek, Stephanie M. Nichols-Burns, Yifei Liu, Jonathan Lo, Dawn A. Kelk, Valerie Flores, Xiao-Bing Gao, Emre Seli Tags: Video Source Type: research

Effect of a 6-week “Mediterranean” dietary intervention on in vitro human embryo development: the Preconception Dietary Supplements in Assisted Reproduction double-blinded randomized controlled trial
To study the impact of increased dietary intake of omega-3 fatty acids, vitamin D, and olive oil for 6 weeks before in  vitro fertilization (IVF) or IVF–intracytoplasmic sperm injection (ICSI) on morphokinetic markers of early embryo development. (Source: Fertility and Sterility)
Source: Fertility and Sterility - December 20, 2019 Category: Reproduction Medicine Authors: Alexandra J. Kermack, Philippa Lowen, Susan J. Wellstead, Helena L. Fisk, Markus Montag, Ying Cheong, Clive Osmond, Franchesca D. Houghton, Philip C. Calder, Nick S. Macklon Tags: Original article Source Type: research

Thank You to Our Reviewers
No journal can be successful without the support of professionals in the field who donate their time and expertise in reviewing manuscripts. Below is the list of reviewers who submitted their comments between November 1, 2018 and October 31, 2019. We would like to express our sincere gratitude to all of them. (Source: Fertility and Sterility)
Source: Fertility and Sterility - December 19, 2019 Category: Reproduction Medicine Tags: From the editors Source Type: research

Luteal phase after conventional stimulation in the same ovarian cycle might improve the management of poor responder patients fulfilling the Bologna criteria: a case series
To assess the clinical contribution of luteal-phase stimulation (LPS) to follicular-phase stimulation (FPS) in a single ovarian cycle (DuoStim) for poor responder patients fulfilling the Bologna criteria. (Source: Fertility and Sterility)
Source: Fertility and Sterility - December 16, 2019 Category: Reproduction Medicine Authors: Alberto Vaiarelli, Danilo Cimadomo, Alessandro Conforti, Mauro Schimberni, Maddalena Giuliani, Pietro D ’Alessandro, Silvia Colamaria, Carlo Alviggi, Laura Rienzi, Filippo Maria Ubaldi Tags: Original article Source Type: research

Levels of angiogenic markers in second-trimester maternal serum from in  vitro fertilization pregnancies with oocyte donation
To determine whether differences exist in angiogenic placental growth factor (PlGF) and antiangiogenic soluble vascular endothelial growth factor receptor 1 (sVEGFR-1; both being early markers of placental ischemic disease) in oocyte-donation (OD) pregnancies, compared with autologous in  vitro fertilization (aIVF) and spontaneous pregnancies. (Source: Fertility and Sterility)
Source: Fertility and Sterility - December 1, 2019 Category: Reproduction Medicine Authors: Yelena Dondik, Kelly Pagidas, Elizabeth Eklund, Christina Ngo, Glenn E. Palomaki, Geralyn Lambert-Messerlian Tags: Original article Source Type: research

Time of morulation and trophectoderm quality are predictors of a live birth after euploid blastocyst transfer: a multicenter study
To investigate whether the morphodynamic characterization of a euploid blastocyst's development allows a higher prediction of a live birth after single-embryo-transfer (SET). (Source: Fertility and Sterility)
Source: Fertility and Sterility - December 1, 2019 Category: Reproduction Medicine Authors: Laura Rienzi, Danilo Cimadomo, Arantxa Delgado, Maria Giulia Minasi, Gemma Fabozzi, Raquel del Gallego, Marta Stoppa, Jose Bellver, Adriano Giancani, Marga Esbert, Antonio Capalbo, Jose Remoh ì, Ermanno Greco, Filippo Maria Ubaldi, Marcos Meseguer Tags: Original article Source Type: research

Assisted reproductive technology use in the United States: a population assessment
To study social and demographic differentiation of assisted reproduction technology (ART) use at the population level in the United States. (Source: Fertility and Sterility)
Source: Fertility and Sterility - December 1, 2019 Category: Reproduction Medicine Authors: Katherine Tierney, Yong Cai Tags: Original article Source Type: research

Cross-talk between miR-29c and transforming growth factor- β3 is mediated by an epigenetic mechanism in leiomyoma
To determine the expression of miR-29c and its target gene transforming growth factor- β3 (TGF-β3) in leiomyoma and the mechanisms of their reciprocal regulation. (Source: Fertility and Sterility)
Source: Fertility and Sterility - December 1, 2019 Category: Reproduction Medicine Authors: Tsai-Der Chuang, Omid Khorram Tags: Original article Source Type: research

Fertility treatments and offspring pediatric infectious morbidities: results of a population-based cohort with a median follow-up of 10  years
To study the association between mode of conception and offspring infectious morbidity risk. (Source: Fertility and Sterility)
Source: Fertility and Sterility - December 1, 2019 Category: Reproduction Medicine Authors: Tamar Wainstock, Eyal Sheiner, Israel Yoles, Ruslan Sergienko, Daniella Landau, Avi Harlev Tags: Original article Source Type: research

Symptoms of anxiety and depression among Chinese women transitioning through menopause: findings from a prospective community-based cohort study
To determine the prevalence of symptoms of anxiety and depression in Chinese women during and after menopause, and the associated risk factors. (Source: Fertility and Sterility)
Source: Fertility and Sterility - December 1, 2019 Category: Reproduction Medicine Authors: Ruiyi Tang, Min Luo, Jiayi Li, Yajing Peng, Yuchen Wang, Bing Liu, Gaifen Liu, Yaping Wang, Shouqing Lin, Rong Chen Tags: Original article Source Type: research