Protein disulfide isomerase uses thrombin-antithrombin complex as a template to bind its target protein and alter the blood coagulation rates
Biosci Rep. 2024 Apr 25:BSR20231540. doi: 10.1042/BSR20231540. Online ahead of print.ABSTRACTDuring inflammation and situations of cellular stress Protein Disulfide Isomerase (PDI) is released in the blood plasma from the platelet and endothelial cells to influence thrombosis. The addition of exogenous PDI makes the environment pro-thrombotic by inducing disulfide bond formation in specific plasma protein targets like vitronectin, factor V, and factor XI. However, the mechanistic details of PDI interaction with its target remain largely unknown. A decrease in the coagulation time was detected in activated partial thrombopl...
Source: Bioscience Reports - April 25, 2024 Category: Biomedical Science Authors: Abdul Burhan Khan Urfi Siddiqui Sana Fatima Ahmed Abdur Rehman Mohamad Aman Jairajpuri Source Type: research
A short-term rodent model for non-alcoholic steatohepatitis induced by a high-fat diet and carbon tetrachloride
This study aimed to evaluate the joint action of a high-fat diet and CCl4 in developing a short-term non-alcoholic steatohepatitis model. C57BL6/J mice were divided into two groups: standard diet-fed (SD), the high-fat diet-fed (HFD) and HFD + fructose-fed and carbon tetrachloride (HFD+CCl4). Animals fed with HFD+CCl4 presented increased lipid deposition compared with both SD and HFD mice. Plasma cholesterol was increased in animals from the HFD+CCl4 group compared to the SD and HFD groups, without significant differences between the SD and HFD groups. Plasma triglycerides showed no significant difference between the group...
Source: Bioscience Reports - April 25, 2024 Category: Biomedical Science Authors: Layanne C C Araujo Carolina C B Dias Felipe G Sucupira Leandra N Z Ramalho Joao Paulo Camporez Source Type: research
miRNA-142-3p Aggravates Hydrogen Peroxide-Induced Human Umbilical Vein Endothelial Cell Premature Senescence by Targeting SIRT1
This study aimed to investigate the mechanism of hydrogen peroxide (H2O2)-induced premature senescence in human umbilical vein endothelial cells (HUVECs) and effect of miR-142-3p on hydrogen peroxide (H2O2)-induced premature senescence. HUVECs were exposed to H2O2 to establish a model premature senescence in endothelial cells. CCK-8 assay was performed to detect cell viability. Senescence-associated β-galactosidase staining assay and senescence-related proteins p16 and p21 were used to detect changes in the degree of cell senescence. RT-qPCR and Western blot were conducted to measure mRNA and protein levels, respectively....
Source: Bioscience Reports - April 25, 2024 Category: Biomedical Science Authors: Pengfei Tong Jingke Zhang Shuang Liu Jiyang An Gehan Jing Laifeng Ma Ruihua Wang Zhengfeng Wang Source Type: research
Cardiomyocyte-specific deletion of the mitochondrial transporter Abcb10 causes cardiac dysfunction via lysosomal-mediated ferroptosis
Biosci Rep. 2024 Apr 24:BSR20231992. doi: 10.1042/BSR20231992. Online ahead of print.ABSTRACTHeart function is highly dependent on mitochondria, which not only produce energy but also regulate many cellular functions. Therefore, mitochondria are important therapeutic targets in heart failure. Abcb10 is a member of the ABC transporter superfamily located in the inner mitochondrial membrane and plays an important role in haemoglobin synthesis, biliverdin transport, antioxidant stress, and stabilization of the iron transporter mitoferrin-1. However, the mechanisms underlying the impairment of mitochondrial transporters in the...
Source: Bioscience Reports - April 24, 2024 Category: Biomedical Science Authors: Yura Do Mikako Yagi Haruka Hirai Kenji Miki Yukina Fikahori Daiki Setoyama Masatatsu Yamamoto Tatsuhiko Furukawa Yuya Kunishaki Dongchon Kang Takeshi Uchiumi Source Type: research
Expression of Concern: C-reactive protein promotes inflammation through TLR4/NF- κB/TGF-β pathway in HL-1 cells
Biosci Rep. 2024 Apr 24;44(4):BSR-2019-0888_EOC. doi: 10.1042/BSR-2019-0888_EOC.NO ABSTRACTPMID:38655837 | DOI:10.1042/BSR-2019-0888_EOC (Source: Bioscience Reports)
Source: Bioscience Reports - April 24, 2024 Category: Biomedical Science Source Type: research
Retraction: Role of SDF-1 α/CXCR4 signaling pathway in clinicopathological features and prognosis of patients with nasopharyngeal carcinoma
Biosci Rep. 2024 Apr 24;44(4):BSR-2017-0144_RET. doi: 10.1042/BSR-2017-0144_RET.NO ABSTRACTPMID:38655838 | DOI:10.1042/BSR-2017-0144_RET (Source: Bioscience Reports)
Source: Bioscience Reports - April 24, 2024 Category: Biomedical Science Source Type: research
VDR is a potential prognostic biomarker and positively correlated with immune infiltration: a comprehensive pan-cancer analysis with experimental verification
In conclusion, VDR is a potential prognostic biomarker and positively correlated with immune infiltration as well as stromal or immune components in TME in multiple human cancers.PMID:38639057 | DOI:10.1042/BSR20231845 (Source: Bioscience Reports)
Source: Bioscience Reports - April 19, 2024 Category: Biomedical Science Authors: Xuedi Xia Feng Xu Dexing Dai An Xiong Ruoman Sun Yali Ling Lei Qiu Rui Wang Ya Ding Miaoying Lin Haibo Li Zhongjian Xie Source Type: research
VDR is a potential prognostic biomarker and positively correlated with immune infiltration: a comprehensive pan-cancer analysis with experimental verification
In conclusion, VDR is a potential prognostic biomarker and positively correlated with immune infiltration as well as stromal or immune components in TME in multiple human cancers.PMID:38639057 | DOI:10.1042/BSR20231845 (Source: Bioscience Reports)
Source: Bioscience Reports - April 19, 2024 Category: Biomedical Science Authors: Xuedi Xia Feng Xu Dexing Dai An Xiong Ruoman Sun Yali Ling Lei Qiu Rui Wang Ya Ding Miaoying Lin Haibo Li Zhongjian Xie Source Type: research
Molecular Regulation of NLRP3 Inflammasome Activation During Parasitic Infection
Biosci Rep. 2024 Apr 16:BSR20231918. doi: 10.1042/BSR20231918. Online ahead of print.ABSTRACTParasitic diseases are a serious global health concern, causing many common and severe infections, including Chagas disease, leishmaniasis,and schistosomiasis. The NLRP3 inflammasome belongs to the NLR (nucleotide-binding domain leucine-rich-repeat-containing proteins) family, which are cytosolic proteins playing key roles in the detection of pathogens. NLRP3 inflammasomes are activated in immune responses to Plasmodium,Leishmania, Toxoplasma gondii, Entamoeba histolytica,Trypanosoma cruzi and other parasites. The role of NLRP3 is ...
Source: Bioscience Reports - April 16, 2024 Category: Biomedical Science Authors: Rasha Alonaizan Source Type: research
Molecular Regulation of NLRP3 Inflammasome Activation During Parasitic Infection
Biosci Rep. 2024 Apr 16:BSR20231918. doi: 10.1042/BSR20231918. Online ahead of print.ABSTRACTParasitic diseases are a serious global health concern, causing many common and severe infections, including Chagas disease, leishmaniasis,and schistosomiasis. The NLRP3 inflammasome belongs to the NLR (nucleotide-binding domain leucine-rich-repeat-containing proteins) family, which are cytosolic proteins playing key roles in the detection of pathogens. NLRP3 inflammasomes are activated in immune responses to Plasmodium,Leishmania, Toxoplasma gondii, Entamoeba histolytica,Trypanosoma cruzi and other parasites. The role of NLRP3 is ...
Source: Bioscience Reports - April 16, 2024 Category: Biomedical Science Authors: Rasha Alonaizan Source Type: research
Molecular Regulation of NLRP3 Inflammasome Activation During Parasitic Infection
Biosci Rep. 2024 Apr 16:BSR20231918. doi: 10.1042/BSR20231918. Online ahead of print.ABSTRACTParasitic diseases are a serious global health concern, causing many common and severe infections, including Chagas disease, leishmaniasis,and schistosomiasis. The NLRP3 inflammasome belongs to the NLR (nucleotide-binding domain leucine-rich-repeat-containing proteins) family, which are cytosolic proteins playing key roles in the detection of pathogens. NLRP3 inflammasomes are activated in immune responses to Plasmodium,Leishmania, Toxoplasma gondii, Entamoeba histolytica,Trypanosoma cruzi and other parasites. The role of NLRP3 is ...
Source: Bioscience Reports - April 16, 2024 Category: Biomedical Science Authors: Rasha Alonaizan Source Type: research
Expression of Concern: MiR-302e attenuates allergic inflammation in vitro model by targeting RelA
Biosci Rep. 2024 Apr 24;44(4):BSR-2018-0025_EOC. doi: 10.1042/BSR-2018-0025_EOC.NO ABSTRACTPMID:38606536 | PMC:PMC11016530 | DOI:10.1042/BSR-2018-0025_EOC (Source: Bioscience Reports)
Source: Bioscience Reports - April 12, 2024 Category: Biomedical Science Source Type: research
Me31B, A Key Repressor in Germline Regulation and Beyond
This article endeavors to comprehensively review historic and recent research on Me31B, distill the major findings, discern generalizable patterns in Me31B's functions across different research contexts, and provide insights into its fundamental role and mechanism of action. The primary focus of this article centers on elucidating the role of Drosophila Me31B within the germline, while concurrently delving into pertinent research on its orthologs within other species and cellular systems.PMID:38606619 | DOI:10.1042/BSR20231769 (Source: Bioscience Reports)
Source: Bioscience Reports - April 12, 2024 Category: Biomedical Science Authors: Ming Gao Source Type: research
Expression of Concern: MiR-302e attenuates allergic inflammation in vitro model by targeting RelA
Biosci Rep. 2024 Apr 24;44(4):BSR-2018-0025_EOC. doi: 10.1042/BSR-2018-0025_EOC.NO ABSTRACTPMID:38606536 | DOI:10.1042/BSR-2018-0025_EOC (Source: Bioscience Reports)
Source: Bioscience Reports - April 12, 2024 Category: Biomedical Science Source Type: research
Me31B, A Key Repressor in Germline Regulation and Beyond
This article endeavors to comprehensively review historic and recent research on Me31B, distill the major findings, discern generalizable patterns in Me31B's functions across different research contexts, and provide insights into its fundamental role and mechanism of action. The primary focus of this article centers on elucidating the role of Drosophila Me31B within the germline, while concurrently delving into pertinent research on its orthologs within other species and cellular systems.PMID:38606619 | DOI:10.1042/BSR20231769 (Source: Bioscience Reports)
Source: Bioscience Reports - April 12, 2024 Category: Biomedical Science Authors: Ming Gao Source Type: research
