ATM rs189037 significantly Increases the Risk of Cancer in Non-smokers Rather than Smokers: An updated Meta-analysis.
Abstract Rs189037 (G>A) is an important functional variant with ataxia telangiectasia mutated ( ATM ) gene, which might affect ATM 's expression to involve in several human cancers. Increasing evidence reveals that smoking-related cancers have distinct molecular characteristics from non-smoking cancers. By now, the role of ATM rs189037 in cancer risk stratified by smoking status still remains unclear. To evaluate the association between ATM rs189037 and cancer risk based on smoking status, we performed this meta-analysis by a comprehensive literature search via databases of PubMed, Embase, Web of Science and CN...
Source: Bioscience Reports - June 14, 2019 Category: Biomedical Science Authors: He X, Wang P, Li Y, Shen N Tags: Biosci Rep Source Type: research

Inhibition of GLS suppresses proliferation and promotes apoptosis in prostate cancer.
Abstract Altered glutamine metabolism is a hallmark of cancer growth, forming the theoretical basis for development of metabolic therapies as cancer treatments. Glutaminase (GLS), a crucial enzyme involved in the regulation of glutamine metabolism, has been reported to play crucial roles in cancer development. However, the precise function of GLS in prostate cancer (PCa) remains unclear. The purpose of the present study was to assess the GLS expression and its clinical significance in PCa. We found that GLS was significantly upregulated in PCa tissues and cell lines. High expression of GLS was significantly associ...
Source: Bioscience Reports - June 13, 2019 Category: Biomedical Science Authors: Zhang J, Mao SY, Guo YD, Wu Y, Huang Y, Yao XD Tags: Biosci Rep Source Type: research

Differential gene expression in articular cartilage between rheumatoid arthritis and endemic Kashin-Beck disease.
In conclusion, gene expression profiling can be used to identify the different mechanism of pathogenesis between KBD and RA. PMID: 31196963 [PubMed - as supplied by publisher] (Source: Bioscience Reports)
Source: Bioscience Reports - June 13, 2019 Category: Biomedical Science Authors: Gao Z, Duan C, Yu FF, Guo X Tags: Biosci Rep Source Type: research

Diagnostic value of RASSF1A methylation for breast cancer :a meta-analysis.
CONCLUSIONS: RASSF1A methylation might be a potential diagnostic biomarker for BC. Considering its low sensitivity and high specificity, it should combine with others to upgrade the sensitivity. Besides, under such conditions as MSP detection, serum RASSF1A methylation and in Caucasian it shown more effective and suitable for diagnosing BC. PMID: 31196964 [PubMed - as supplied by publisher] (Source: Bioscience Reports)
Source: Bioscience Reports - June 13, 2019 Category: Biomedical Science Authors: Li M, Wang C, Yu B, Zhang X, Shi F, Liu X Tags: Biosci Rep Source Type: research

Accurately cleavable goat beta-lactoglobulin signal peptide efficiently guided translation of a recombinant human plasminogen activator in transgenic rabbit mammary gland.
Abstract Poor expression is the key factor hampering the large-scale application of transgenic animal mammary gland bioreactors. A very different approach would be to evaluate the secretion of recombinant proteins into milk in response to a cleavable signal peptide of highly secreted lactoproteins. We previously reported rabbits harboring mammary gland-specific expression vector containing a fusion cDNA (goat BLG signal peptide and recombinant human plasminogen activator (rhPA) coding sequences) expressed rhPA in the milk, but we didn't realize the signal peptide contributed to the high rhPA concentration and didn...
Source: Bioscience Reports - June 13, 2019 Category: Biomedical Science Authors: Lu R, Zhang T, Song S, Zhou M, Jiang L, He Z, Yuan Y, Yuan T, Lu Y, Yan K, Cheng Y Tags: Biosci Rep Source Type: research

Investigation of leptin receptor rs1137101 G > A polymorphism with cancer risk: evidence from 35,936 subjects.
Investigation of leptin receptor rs1137101 G>A polymorphism with cancer risk: evidence from 35,936 subjects. Biosci Rep. 2019 Jun 13;: Authors: Rong G, Tang W, Wang Y, Qiu H, Chen S Abstract Leptin receptor (LEPR) signaling may involve in promoting angiogenesis and proliferation, inhibiting apoptosis and plays a vital role in the progression of carcinogenesis. A number of studies have focused on the association of LEPR rs1137101 variants with susceptibility of cancer, however, the observed results were controversial. We searched literature on the relationship of LEPR rs1137101 G>A polymorphism w...
Source: Bioscience Reports - June 13, 2019 Category: Biomedical Science Authors: Rong G, Tang W, Wang Y, Qiu H, Chen S Tags: Biosci Rep Source Type: research

microRNA-613 exerts anti-angiogenic effect on nasopharyngeal carcinoma cells through inactivating the AKT signaling pathway by downregulating FN1.
CONCLUSION: Taken together, miR-613 inhibits angiogenesis in NPC cells through inactivating FN1-dependent AKT signaling pathway. PMID: 31189740 [PubMed - as supplied by publisher] (Source: Bioscience Reports)
Source: Bioscience Reports - June 12, 2019 Category: Biomedical Science Authors: Gao R, Feng Q, Tan G Tags: Biosci Rep Source Type: research

Efficacy and adverse reaction to different doses of atorvastatin in the treatment of type II diabetes mellitus.
CONCLUSION: These data revealed that ATV could improve the lipid metabolism in T2DM rats and 40 mg/(kg·d) may serve as the optimal dose for the reduction of lipid levels and the incidence of adverse effects. PMID: 31189741 [PubMed - as supplied by publisher] (Source: Bioscience Reports)
Source: Bioscience Reports - June 12, 2019 Category: Biomedical Science Authors: Jiang H, Zheng H Tags: Biosci Rep Source Type: research

LncRNA ANRIL affects the sensitivity of ovarian cancer to cisplatin via regulation of let-7a/HMGA2 axis.
Abstract This paper tried to explore ANRIL expression in ovarian cancer and how it affects cisplatin-sensitivity of ovarian cancer cells via regulation of let-7a/HMGA2 axis. qRT-PCR was used to detect ANRIL and let-7a levels in ovarian cancer tissues and cell lines (SKOV3 and SKOV3/DDP). Then cells were randomly assigned into Blank, NC siRNA, ANRIL siRNA, let-7a inhibitor, and ANRIL siRNA+let-7a inhibitor groups. CCK-8 assay was applied for assessing cell viability of cells treated with different concentrations of cisplatin . Flow cytometry was employed to test cell apoptosis rate. QRT-PCR and Western blot were pe...
Source: Bioscience Reports - June 12, 2019 Category: Biomedical Science Authors: Miao JT, Gao JH, Chen YQ, Chen H, Meng HY, Lou G Tags: Biosci Rep Source Type: research

High-throughput sequencing reveals circular RNA hsa_circ_0000592 as a novel player in Carcinogenesis in gastric carcinoma.
Conclusion: This study is the first to identify hsa_circ_0000592 as a novel circRNA with a critical role in MNNG-induced gastric cancer. Due to the essential role of hsa_circ_0000592 in gastric carcinoma cells, it may be considered as a potential biomarker for use in diagnosing gastric carcinoma. Our findings provide a new insight into the function of circRNAs in environmental carcinogen-induced gastric cancer. PMID: 31189743 [PubMed - as supplied by publisher] (Source: Bioscience Reports)
Source: Bioscience Reports - June 12, 2019 Category: Biomedical Science Authors: Liang M, Liu Z, Lin H, Shi B, Li M, Chen T, Qin L, Niu Q, Yu G, Jiang H, Zhou X Tags: Biosci Rep Source Type: research

Down-regulation of SOX18 inhibits laryngeal carcinoma cell proliferation, migration, and invasion through JAK2/STAT3 signaling.
Abstract Laryngeal carcinoma is one of the most common malignant tumors of the head, neck, and respiratory tract. The aim of this study is to explore the biological function of SRY-related HMG-box 18 (SOX18) in laryngeal carcinoma cells and study the molecular mechanism involved. Initial findings indicate that the expression of SOX18 was increased in laryngeal carcinoma cell lines and tissues. The effect of SOX18 on laryngeal carcinoma cell proliferation, cell cycle, apoptosis, invasion, and migration was also identified. The results indicated that down-regulation of SOX18 significantly inhibited cell proliferatio...
Source: Bioscience Reports - June 12, 2019 Category: Biomedical Science Authors: Xu Y, Zhang Q, Zhou J, Li Z, Guo J, Wang W, Wang W Tags: Biosci Rep Source Type: research

Genome survey and SSR analysis of Apocynum venetum.
Abstract Apocynum venetum is an eco-economic plant that exhibits high stress resistance. In this paper, we carried out a whole-genome survey of A. venetum in order to provide a foundation for its whole-genome sequencing. High-throughput sequencing technology (Illumina NovaSep) was first used to measure the genome size of A. venetum, and bioinformatics methods were employed for the evaluation of the genome size, heterozygosity ratio, repeated sequences, and GC content in order to provide a foundation for subsequent whole-genome sequencing. The sequencing analysis results indicated that the preliminary estimated gen...
Source: Bioscience Reports - June 12, 2019 Category: Biomedical Science Authors: Li GQ, Song LX, Jin CQ, Li M, Gong SP, Wang YF Tags: Biosci Rep Source Type: research

DEPDC1 promotes cell proliferation and suppresses sensitivity to chemotherapy in human hepatocellular carcinoma.
In this study, we aimed to characterize the biological role of DEPDC1 in HCC and illuminate the potential molecular mechanisms. Here we found that DEPDC1 was significantly up-regulated in HCC tissues compared with adjacent normal tissues. Besides, the log-rank test and Kaplan-Meier survival analysis demonstrated that patients with high DEPDC1 expression experienced a significantly shorter overall survival. Functional investigations showed that DEPDC1 over-expression facilitated HCC cell proliferation and suppressed cell apoptosis, whereas DEPDC1 depletion inhibited HCC cell proliferation and promoted cell apoptosis. In add...
Source: Bioscience Reports - June 12, 2019 Category: Biomedical Science Authors: Zhou C, Wang P, Tu M, Huang Y, Xiong F, Wu Y Tags: Biosci Rep Source Type: research

Phospholipases D- making sense of redundancy and duplication.
Abstract Why have two genes when one would suffice?  Evolutionary pressure means that biology, unlike government, is generally intolerant of wasted effort.  Therefore, when multiple genes exist presumably they are there to provide some benefit to the organism even if that benefit is not immediately obvious to us scientists.  A recent report from Ragu and colleagues (1) sheds some light on one possible reason for the existence of two Phospholipases D genes in chordates when only one is present in invertebrates. PMID: 31189747 [PubMed - as supplied by publisher] (Source: Bioscience Reports)
Source: Bioscience Reports - June 12, 2019 Category: Biomedical Science Authors: Morris AJ Tags: Biosci Rep Source Type: research

Protective effect of Cordyceps sinensis extract on lipopolysaccharide induced acute lung injury in mice.
Abstract BACKGROUND: To study the protective effect of Cordyceps sinensis extract (DCXC) on experimental acute lung injury (ALI) mice. METHODS AND RESULTS: ALI model was induced by intratracheal-instilled lipopolysaccharide (LPS, 2.4 mg/kg) in BALB/c male mice. The mice were administrate DCXC (ig, 10, 30, 60 mg/kg) in 4 and 8 h after receiving LPS. Histopathological section, wet/dry lung weight ratio and myeloperoxidase activity were detected. Bronchoalveolar lavage fluid (BALF) was collected for cell count, the levels of TNF-α, IL-1β, IL-6 and NO in BALF was detected by ELISA, the protein and mRNA...
Source: Bioscience Reports - June 11, 2019 Category: Biomedical Science Authors: Fu S, Lu W, Yu W, Hu J Tags: Biosci Rep Source Type: research

Role of microRNA-15a-5p in the atherosclerotic inflammatory response and arterial injury improvement of diabetic by targeting FASN.
This study aims to investigate the mechanism of miR-15a-5p in the AS inflammatory response and arterial injury improvement in diabetic rats by regulating FASN. Initially, bioinformatic tools were applied to evaluate miRNAs and genes correlating with atherosclerosis, the target relation was then measured using Dual-Luciferase Reporter Assay. Subsequently the diabetic atherosclerosis rat model was established, the survived rats were divided into: NC, miR-15a-5p mimic, miR-15a-5p inhibitor, sh-FASN and miR-15a-5p + sh-FASN groups. Then a series of experiments were performed to examine the degree of atherosclerosis in each gro...
Source: Bioscience Reports - June 10, 2019 Category: Biomedical Science Authors: Liu Y, Liu LY, Jia Y, Sun YY, Ma FZ Tags: Biosci Rep Source Type: research

FEZF1-AS1: A novel vital oncogenic lncRNA in multiple human malignancies.
Abstract Long noncoding RNAs(LncRNAs) refer to the RNA with a length of> 200 nucleotides, which lack or have no open reading coding frame and have higher tissue and organ specificity compared with the protein coding genes. A surging number of studies have shown that lncRNA is involved in numerous essential regulatory processes, such as X chromosome silencing, genomic imprinting, chromatin modification, transcriptional activation, transcriptional interference and nuclear transport, which are closely related to the occurrence and development of human malignancies. FEZ family Zinc Finger 1-Antisense RNA 1 (FEZF1-A...
Source: Bioscience Reports - June 7, 2019 Category: Biomedical Science Authors: Shi C, Sun L, Song Y Tags: Biosci Rep Source Type: research

Changing substrate specificity and iteration of amino acid chain elongation in glucosinolate biosynthesis through targeted mutagenesis of Arabidopsis methylthioalkylmalate synthase1.
Abstract Methylthioalkylmalate synthases catalyse the committing step of amino acid chain elongation in glucosinolate biosynthesis. As such, this group of enzymes plays an important role in determining the glucosinolate composition of Brassicaceae species, including Arabidopsis thaliana Based on protein structure modelling of MAM1 from A. thaliana and analysis of 57 MAM sequences from Brassicaceae species, we identified four polymorphic residues likely to interact with the 2-oxo acid substrate. Through site-directed mutagenesis, the natural variation in these residues and the effect on product composition were inv...
Source: Bioscience Reports - June 7, 2019 Category: Biomedical Science Authors: Petersen A, Hansen LG, Mirza N, Crocoll C, Mirza OA, Halkier BA Tags: Biosci Rep Source Type: research

MiR-876-5p regulates gastric cancer cell proliferation, apoptosis and migration through targeting WNT5A and MITF.
Abstract MicroRNAs (miRNAs) are reported to play critical roles in various cancers. Recently, mounting miRNAs are found to exert oncogenic or tumor inhibitory role in gastric cancer (GC), however, their potential molecular mechanism in GC remains ill-defined. Currently, we aimed to elucidate the functional and mechanistic impacts of a novel miRNA on GC cellular process. The significant downregulation of miR-876-5p in GC cells attracted our attention. In function, we performed gain-of-function assays and found that miR-876-5p overexpression repressed proliferative, anti-apoptotic and migratory abilities and epithel...
Source: Bioscience Reports - June 6, 2019 Category: Biomedical Science Authors: Xu Z, Yu Z, Tan Q, Wei C, Tang Q, Wang L, Hong Y Tags: Biosci Rep Source Type: research

Morusin alleviates mycoplasma pneumonia via the inhibition of Wnt/ β-catenin and NF-κB signaling.
This study aimed to explore the mechanism by which morusin achieves efficacy on mycoplasma pneumonia. Mycoplasma pneumonia model was established in BALB/c mouse and the effects of morusin were evaluated in the model. Compared to model group, DNA amount of M. pneumoniae decreased by 24.6 ± 3.14% and 47.6 ± 6.78% in low morusin (20 mg/kg) and high morusin (50 mg/kg) groups, respectively (P
Source: Bioscience Reports - June 6, 2019 Category: Biomedical Science Authors: Chen C, Wang J, Chen J, Zhou L, Wang H, Chen J, Xu Z, Zhu S, Liu W, Yu R, Lu J, Luo H, Chen M, Chen W Tags: Biosci Rep Source Type: research

Anti-aging effects exerted by Tetramethylpyrazine  enhances self-renewal and neuronal differentiation of rat bMSCs by suppressing NF-kB signaling.
In conclusion, 4 days of 40-50 mg/l TMP treatment may significantly delay bMSC senescence by suppressing NF-κB signaling, and enhancing the self-renewal ability of bMSCs, and their potential for neuronal differentiation. PMID: 31171713 [PubMed - as supplied by publisher] (Source: Bioscience Reports)
Source: Bioscience Reports - June 6, 2019 Category: Biomedical Science Authors: Song X, Dai J, Li H, Li Y, Hao W, Zhang Y, Zhang Y, Su L, Wei H Tags: Biosci Rep Source Type: research

LncRNA PTCSC3 inhibits cell proliferation in laryngeal squamous cell carcinoma by downregulating lncRNA HOTAIR.
Abstract It is known that lncRNA PTCSC3 inhibits thyroid cancer and glioma and STAT3 promotes cancer development. We in this study investigated the potential involvement of PTCSC3 in laryngeal squamous cell carcinoma (LSCC) and explored its interactions with STAT3. In the present study we showed that plasma PTCSC3 was downregulated in early stage LSCC patients, and the downregulation of PTCSC3 separated early stage LSCC patients from control group. LncRNA HOTAIR was upregulated in early stage LSCC patients and was significantly and inversely correlated with PTCSC3 in LSCC patients. PTCSC3 overexpression led to the...
Source: Bioscience Reports - June 6, 2019 Category: Biomedical Science Authors: Xiao D, Cui X, Wang X Tags: Biosci Rep Source Type: research

Identification of core genes and clinical roles in pregnancy-association breast cancer based on integrated analysis of different microarray profile datasets.
In conclusion, ASB6 could be a potential predictor and therapeutic target in patient with PABC. PMID: 31171715 [PubMed - as supplied by publisher] (Source: Bioscience Reports)
Source: Bioscience Reports - June 6, 2019 Category: Biomedical Science Authors: Zhang J, Zhou YJ, Yu ZH, Chen AX, Yu Y, Wang X, Cao XC Tags: Biosci Rep Source Type: research

Conformational changes in Chikungunya virus E2 protein upon heparan sulfate receptor binding explain mechanism of E2-E1 dissociation during viral entry.
Abstract Receptor-binding is the first step in viral cell entry. In enveloped virus cell entry, viral and host membrane fusion follows receptor-binding. Viral surface receptor-binding protein associates with membrane fusion protein and masks its structure, to prevent pre-mature fusion activity. Dissociation of receptor-binding protein from fusion protein is an essential step before membrane fusion. Mechanism of receptor-binding leading to dissociation of receptor-binding and fusion protein is poorly understood in alphaviruses. Chikungunya virus (CHIKV), an alphavirus, re-emerged as a global pathogen in recent past...
Source: Bioscience Reports - June 5, 2019 Category: Biomedical Science Authors: Sahoo B, Chowdary TK Tags: Biosci Rep Source Type: research

LncRNA SAMMSON negatively regulates miR-9-3p in hepatocellular carcinoma cells and has prognostic values.
Abstract In the present study we investigated the role of lncRNA SAMMSON in hepatocellular carcinoma (HCC). We found that SAMMSON was upregulated in HCC tissues, and patients with high levels of SAMMSON in HCC tissues had significantly lower overall rate within 5 years after admission. miR-9-3p was downregulated in HCC tissues and inversely correlated with SAMMSON. SAMMSON expression was not significantly affected by HBV and HCV infections in HCC patients. In HCC cells, SAMMSON overexpression resulted in downregulated miR-9-3p expression, while miR-9-3p overexpression caused no significantly changes in expression ...
Source: Bioscience Reports - June 4, 2019 Category: Biomedical Science Authors: Yang S, Cai H, Hu B, Tu J Tags: Biosci Rep Source Type: research

UGT2B17 and miR-224 contribute to hormone dependency trends in adenocarcinoma and squamous cell carcinoma of esophagus.
Abstract Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EA) are the two main sub-types of esophageal cancer. Genetics underpinnings of EA are substantially less understood than that of ESCC. A large-scale relation data analysis was conducted to explore the genes implicated with either EA or ESCC, or both. Each gene linked to ESCC but not EA was further explored in mega-analysis of 6 independently collected EA RNA expression datasets. A multiple linear regression (MLR) model was built to study the possible influence of sample size, population region, and study date on the gene expression d...
Source: Bioscience Reports - June 4, 2019 Category: Biomedical Science Authors: Lian X, Baranova A, Ngo J, Yu G, Cao H Tags: Biosci Rep Source Type: research

Deorphanizing NUDIX hydrolases from Trypanosoma : Tantalizing links with metabolic regulation and stress tolerance.
Abstract An explosion of sequence information in the genomics era has thrown up thousands of protein sequences without functional assignment. Though our ability to predict function based on sequence alone is improving steadily, we still have a long way to go. Proteins with common evolutionary origins carry telling sequence signatures, which ought to reveal their biological roles. These sequence signatures have allowed us to classify proteins into families with similar structures and, possibly, functions. Yet, evolution is a perpetual tinkerer and hence, sequence signatures alone have proved inadequate in understan...
Source: Bioscience Reports - June 3, 2019 Category: Biomedical Science Authors: Matange N Tags: Biosci Rep Source Type: research

Association of DNAH11 gene polymorphisms with asthenozoospermia in Northeast Chinese patients.
Abstract Reduced or no progressive sperm motility in the fresh ejaculate defines asthenozoospermia as one of the major causes of male infertility. The axonemal heavy chain dynein type 11 ( DNAH11 ) gene encodes for one of the axonemal dynein heavy chain (DHC) family members and participates in assembling respiratory cilia and sperm flagella. Given the high degree of conservation of DNAH11 , mutations could give rise to primary ciliary dyskinesia (PCD) and asthenozoospermia. To date, few studies have reported on the association between variants in DNAH11 and asthenozoospermia. In the present study, 87 patients with...
Source: Bioscience Reports - June 3, 2019 Category: Biomedical Science Authors: Zhu D, Zhang H, Wang R, Liu X, Jiang Y, Feng T, Liu R, Zhang G Tags: Biosci Rep Source Type: research

MiR-505 suppressed the growth of hepatocellular carcinoma cells via targeting IGF-1R.
Abstract Hepatocellular carcinoma (HCC) is one of the most common cancers globally. An increasing body of evidence has demonstrated the critical function of microRNAs (miRNAs) in the initiation and progression of human cancers. Here, we showed that miR-505 was down-regulated in HCC tissues and cell lines. Reduced expression of miR-505 was significantly correlated with the worse prognosis of HCC patients. Overexpression of miR-505 suppressed the proliferation, colony formation and induced apoptosis of both HepG2 and Huh7 cells. Further mechanism study uncovered that miR-505 bound the 3'-untranslated region (UTR) of...
Source: Bioscience Reports - June 3, 2019 Category: Biomedical Science Authors: Ren L, Yao Y, Wang Y, Wang S Tags: Biosci Rep Source Type: research

Non-enzymatic Glucose Sensor with Electrodeposited Silver/Carbon Nanotubes Composite Electrode.
This study indicates that the Ag/CNTs electrode is possible substitute of the expensive glassy carbon electrode for enzyme free glucose sensors. PMID: 31160484 [PubMed - as supplied by publisher] (Source: Bioscience Reports)
Source: Bioscience Reports - June 3, 2019 Category: Biomedical Science Authors: Shabbir SA, Tariq S, Ashiq MGB, Khan W Tags: Biosci Rep Source Type: research

Spontaneous suprachoroidal hemorrhage in a high myopia patient with rhegmatogenous retinal detachment: A case report and literature review.
Conclusion: Advanced age, systemic anticoagulation, and hypertension are strong risk factors. RRD associated with massive SSCH is an extremely rare event. Vitrectomy and choroidal blood drainage can effectively remove suprachoroidal hemorrhage and promote retinal reattachment in these eyes. However, the final visual prognosis usually remains poor. PMID: 31160485 [PubMed - as supplied by publisher] (Source: Bioscience Reports)
Source: Bioscience Reports - June 3, 2019 Category: Biomedical Science Authors: Chai F, Zeng L, Li C, Zhao X Tags: Biosci Rep Source Type: research

Association of STAT3 and STAT4 polymorphisms with susceptibility to chronic hepatitis B virus infection and risk of hepatocellular carcinoma:a meta-analysis.
Abstract BACKGROUND: It has been reported that polymorphisms of signal transducer and activator of transcription (STAT ) 3 and STAT4 might be associated with susceptibility to hepatitis B virus (HBV) infection and risk of chronic hepatocellular carcinoma (HCC). Owing to limitation of sample size and inconclusive results, we conducted a meta-analysis to clarify the association. METHODS: We identified relevant studies by a systematic search of Medline/PubMed, EMBASE, Web of Science and the Cochrane Library through Feb.20.2019. The strength of the association measured by odds ratios (OR) with 95% confidence inte...
Source: Bioscience Reports - June 3, 2019 Category: Biomedical Science Authors: Shi H, He H, Ojha SC, Sun C, Fu J, Yan M, Deng C, Sheng YJ Tags: Biosci Rep Source Type: research

Regulatory Mechanisms of Robo4 and Their Effects on Angiogenesis.
Abstract Roundabout4 (Robo4) is a transmembrane receptor that belongs to the Roundabout (Robo) family of axon guidance molecules. Robo4 is an endothelial-specific receptor that participates in endothelial cell migration, proliferation, and angiogenesis and the maintenance of vasculature homeostasis. The purpose of this review is to summarize and analyze three main mechanisms related to the expression and function of Robo4 during developmental and pathological angiogenesis. In this review, static shear stress and the binding of transcription factors such as E26 transformation-specific variant 2 (ETV2) and Slit3 ind...
Source: Bioscience Reports - June 3, 2019 Category: Biomedical Science Authors: Dai C, Gong Q, Cheng Y, Su G Tags: Biosci Rep Source Type: research

The Emerging Role of Circular RNAs in Breast Cancer.
Abstract Breast cancer (BCa) is one of the most frequently diagnosed cancers and leading cause of cancer death among females worldwide. Circular RNAs (circRNAs) as a new class of endogenous regulatory RNAs characterized by circular shape resulting from covalently closed continuous loops that are capable of regulating gene expression at transcription or post-transcription levels. With the unique structures, circRNAs are resistant to exonuclease RNase R and maintain stability more easily than linear RNAs. Recently, an increasing number of circRNAs are discovered and reported to show different expression in BCa and t...
Source: Bioscience Reports - June 3, 2019 Category: Biomedical Science Authors: Zhou SY, Chen W, Yang SJ, Xu ZH, Hu JH, Zhang HD, Zhong SL, Tang JH Tags: Biosci Rep Source Type: research

Glypican-3 promotes cell proliferation and tumorigenesis through up-regulation of b-catenin expression in lung squamous cell carcinoma.
In conclusion, the present study demonstrates that upregulation of GPC3 accelerates the progression of lung SCC in a b-catenin-dependent manner. Our study provides a theoretical basis for GPC3/b-catenin as a novel diagnostic marker and therapeutic target for lung SCC. PMID: 31160489 [PubMed - as supplied by publisher] (Source: Bioscience Reports)
Source: Bioscience Reports - June 3, 2019 Category: Biomedical Science Authors: Wang D, Gao Y, Zhang Y, Wang L, Chen G Tags: Biosci Rep Source Type: research

Down-regulation of microRNA-138 improves immunologic function via negatively targeting p53 by regulating liver macrophage in mice with acute liver failure.
In conclusion, by negatively targeting p53, decreased miR-138 improves immunologic function by regulating liver macrophage in mouse model of ALF. PMID: 31152110 [PubMed - as supplied by publisher] (Source: Bioscience Reports)
Source: Bioscience Reports - May 31, 2019 Category: Biomedical Science Authors: Wang YQ, Lan YY, Guo YC, Yuan QW, Liu P Tags: Biosci Rep Source Type: research

High alpha B-crystallin and p53 coexpression is associated with poor prognosis in ovarian cancer.
This study investigated the correlation between alpha B-crystallin (CRYAB, HSPB5) and p53 expression in ovarian cancer and further analyzed the relationship between their expression and clinicopathology and the prognostic value of their coexpression in ovarian cancer. CRYAB and p53 expression was assessed using immunohistochemistry on ovarian cancer tumor tissues from 103 cases and validated in an independent group of 103 ovarian cancer patients. High CRYAB and p53 expression rates in ovarian cancer tissues were 61.17% and 57.28%, respectively, and their expression was positively correlated. High CRYAB and p53 coexpression...
Source: Bioscience Reports - May 31, 2019 Category: Biomedical Science Authors: Tan L, Sha L, Hou N, Zhang M, Ma Q, Shi C Tags: Biosci Rep Source Type: research

Cholesterol efflux capacity assay using immobilized liposomes and apolipoprotein B-depleted serum.
Abstract Cholesterol efflux capacity (CEC), an important functional step in reverse cholesterol transport, is the main anti-atherosclerotic function of high-density lipoprotein (HDL). Assays that improve the determination of CEC ex-vivo for clinical applications are constantly explored. In the accompanying article, Horiuchi et al, evaluate the availability of apolipoprotein B-depleted serum for CEC assays. Using their recently developed immobilized liposome-bound gel beads (ILG) method, Horiuchi et al, demonstrate that apolipoprotein B-depleted serum obtained with poly ethylene glycol precipitation enables CEC ass...
Source: Bioscience Reports - May 31, 2019 Category: Biomedical Science Authors: Sapa H Tags: Biosci Rep Source Type: research

Correction: Association between polymorphism in the promoter region of lncRNA GAS5 and the risk of colorectal cancer.
Authors: PMID: 31113845 [PubMed - in process] (Source: Bioscience Reports)
Source: Bioscience Reports - May 24, 2019 Category: Biomedical Science Tags: Biosci Rep Source Type: research

Biological enrichment prediction of polychlorinated biphenyls and novel molecular design based on 3D-QSAR/HQSAR associated with molecule docking.
Abstract Based on the experimental data of octanol-water partition coefficients (K ow, represents bioaccumulation) for 13 polychlorinated biphenyl (PCB) congeners, comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) were used to establish 3D-QSAR models, combined with the hologram quantitative structure-activity relationship (HQSAR), the substitution sites (mono-substituted and bis-substituted) and substituent groups (electron-withdrawing hydrophobic groups) that significantly affect the octanol-water partition coefficients values of PCBs were identified, a t...
Source: Bioscience Reports - May 20, 2019 Category: Biomedical Science Authors: Yang J, Gu W, Li Y Tags: Biosci Rep Source Type: research

Correction: Discussion of relationships among changes of pathological indicators, postoperative lymphedema of the upper limb and prognosis of breast cancer patients.
Discussion of relationships among changes of pathological indicators, postoperative lymphedema of the upper limb and prognosis of breast cancer patients. Biosci Rep. 2019 May 31;39(5): Authors: PMID: 31092724 [PubMed - in process] (Source: Bioscience Reports)
Source: Bioscience Reports - May 17, 2019 Category: Biomedical Science Tags: Biosci Rep Source Type: research

Autologous activated platelet rich plasma injection into adult human ovary tissue: Molecular mechanism, analysis, and discussion of reproductive response.
Abstract In clinical infertility practice, one intractable problem is low (or absent) ovarian reserve which in turn reflects the natural oocyte depletion associated with advancing maternal age. The number of available eggs has been generally thought to be finite and strictly limited, an entrenched and largely unchallenged tenet dating back more than 50 years. In the past decade, it has been suggested that renewable ovarian germline stem cells (GSCs) exist in adults, and that such cells may be utilized as an oocyte source for women seeking to extend fertility. Currently, the issue of whether mammalian females posse...
Source: Bioscience Reports - May 15, 2019 Category: Biomedical Science Authors: Sills ES, Wood SH Tags: Biosci Rep Source Type: research

Prognostic Value of Magnetic Resonance Imaging Features in Low-Grade Gliomas.
CONCLUSION: Our study suggests that cyst formation and ring-like enhancement on pre-operative MR images can be useful to predict a favorable prognosis in patients with LGGs. PMID: 31092699 [PubMed - as supplied by publisher] (Source: Bioscience Reports)
Source: Bioscience Reports - May 15, 2019 Category: Biomedical Science Authors: Deng L, Shen L, Shen L, Zhao Z, Peng Y, Liu H, Liu H, Zhang G, Li Z, Li K, Shen E, Liu Y, Liu C, Huang X Tags: Biosci Rep Source Type: research

Long non-coding RNA SPRY4-IT1 promotes epithelial-mesenchymal transition of cervical cancer by regulating the miR-101-3p/ZEB1 axis.
CONCLUSIONS: Our findings indicate that the SPYR4-IT1/miR-101-3p /ZEB1 axis contributes to cervical cancer migration and invasion, which may provide novel insights into the function of lncRNA-driven tumorigenesis of cervical cancer. PMID: 31092700 [PubMed - as supplied by publisher] (Source: Bioscience Reports)
Source: Bioscience Reports - May 15, 2019 Category: Biomedical Science Authors: Fan MJ, Zou YZ, He PJ, Zhang S, Sun XM, Li CZ Tags: Biosci Rep Source Type: research

Short-term and long-term prognostic value of circulating soluble suppression of tumorigenicity-2 concentration in acute coronary syndrome: a meta-analysis.
We reported the prognostic value of sST2 concentration for all-cause mortality, heart failure (HF) events, and major adverse cardiovascular events (MACEs) within one month after hospitalization and during subsequent follow-up. RESULTS: Twelve studies with 11,690 ACS patients were included. Higher baseline sST2 concentration as continuous variables predict the increased risk of all-cause mortality (risk ratio [RR]: 3.16, p = 0.002), HF events (RR: 1.48, p
Source: Bioscience Reports - May 15, 2019 Category: Biomedical Science Authors: Gu L, Li J Tags: Biosci Rep Source Type: research

Identification of Key Genes Involved in Type 2 Diabetic Islet Dysfunction :a Bioinformatics Study.
Conclusion: Bioinformatics analysis revealed that ACLY and the pathways involved are possible target in the molecular mechanism of type 2 diabetes. PMID: 31088900 [PubMed - as supplied by publisher] (Source: Bioscience Reports)
Source: Bioscience Reports - May 14, 2019 Category: Biomedical Science Authors: Zhong M, Wu Y, Yang L, Ou W, Huang L Tags: Biosci Rep Source Type: research

Adiponectin and the risk of new-onset atrial fibrillation: a meta-analysis of prospective cohort studies.
Abstract BACKGROUND: Adiponectin has been suggested as a marker of many cardiovascular diseases. However, the association between serum adiponectin and incidence of atrial fibrillation (AF) in general population remains unclear. A meta-analysis was performed to systematically evaluate the potential influence of serum adiponectin at baseline on the incidence of AF during follow-up in general population. METHODS: Prospective cohort studies were identified via electronic search of PubMed and Embase databases. A randomized effect model was applied to combine the results. Predefined subgroup analyses were performe...
Source: Bioscience Reports - May 14, 2019 Category: Biomedical Science Authors: Guo Y, Liu L, Wang J Tags: Biosci Rep Source Type: research

Knockdown of Tcf3 enhances the wound healing effect of bone marrow mesenchymal stem cells in rat.
Abstract The aim of this study was to explore the wound healing effect of Tcf3 in rat BMSCs and their effects on wound healing. Epidermal growth factor (EGF) and fibroblast growth factors (FGFs) were used to induce BMSCs differentiation into epithelial-like cells. Western Blotting analysis and RT-qPCR were performed to assess the expression levels of Tcf3 and the markers of epithelial-like cells, such as Cytokeratin-18 (CK-18), CK-19 and P63. CCK-8 and clone formation assay were carried out to detect cell viability. Immunohistochemistry  and HE staining were used to assess the level of Tcf3 protein and skin r...
Source: Bioscience Reports - May 13, 2019 Category: Biomedical Science Authors: He B, Chen J, Liu L, Wang H, Wang S, Li P, Zhou J Tags: Biosci Rep Source Type: research

Long non-coding RNA MEG3 serves as a ceRNA for microRNA-145 to induce apoptosis of AC16 cardiomyocytes under high glucose condition.
In this study, we aimed to explore the potential role of long non-coding RNA MEG3 and to investigate the underlying mechanisms in human AC16 cardiomyocytes under high glucose (HG) condition. The results demonstrated that MEG3 was overexpressed in HG-treated AC16 cells, and MEG3 knockdown suppressed the HG-induced apoptosis in AC16 cells. Mechanistically, MEG3 directly binds to miR-145 in AC16 cells, thereby upregulating the expression of PDCD4. Rescue experiments showed that the role of MEG3 in HG-treated AC16 cells was partly dependent on its suppression on miR-145. In summary, our findings suggested that the role of MEG3...
Source: Bioscience Reports - May 13, 2019 Category: Biomedical Science Authors: Chen Y, Zhang Z, Zhu D, Zhao W, Li F Tags: Biosci Rep Source Type: research

miR-940 potentially promotes proliferation and metastasis of endometrial carcinoma through regulation of MRVI1.
In conclusion, our study demonstrates that miR-940 might function as a reliable diagnostic and prognostic signature in EC. PMID: 31085718 [PubMed - as supplied by publisher] (Source: Bioscience Reports)
Source: Bioscience Reports - May 13, 2019 Category: Biomedical Science Authors: Zhou Z, Xu YP, Wang LJ, Kong Y Tags: Biosci Rep Source Type: research