Excitation energy transfer in proteoliposomes reconstituted with LH2 and RC-LH1 complexes from Rhodobacter sphaeroides
Biosci Rep. 2024 Jan 16:BSR20231302. doi: 10.1042/BSR20231302. Online ahead of print.ABSTRACTLight-harvesting 2 (LH2) and reaction-centre light-harvesting 1 (RC-LH1) complexes purified from the photosynthetic bacterium Rhodobacter (Rba.) sphaeroides were reconstituted into proteoliposomes either separately, or together at three different LH2:RC-LH1 ratios, for excitation energy transfer studies. Atomic force microscopy (AFM) was used to investigate the distribution and association of the complexes within the proteoliposome membranes. Absorption and fluorescence emission spectra were similar for LH2 complexes in detergent a...
Source: Bioscience Reports - January 16, 2024 Category: Biomedical Science Authors: Xia Huang Cvetelin Vasilev David Jk Swainsbury C Neil Hunter Source Type: research
Metabolic and behavioral alterations associated with viral vector-mediated toxicity in the paraventricular hypothalamic nucleus
CONCLUSIONS: Our findings reveal that delivery of a specific batch of AAV-Cre could lead to cellular toxicity and lesions in the PVN that cause robust metabolic and behavioral impacts. These alterations can complicate the interpretation of Cre-mediated gene knockout and highlight the need for rigorous controls.PMID:38227343 | PMC:PMC10830444 | DOI:10.1042/BSR20231846 (Source: Bioscience Reports)
Source: Bioscience Reports - January 16, 2024 Category: Biomedical Science Authors: Rohan Savani Erin Park Nidhi Busannagari Yi Lu Hyokjoon Kwon Le Wang Zhiping P Pang Source Type: research
Lipid-based Nutritional Supplement Impact on Energy Intake, Appetite, Glucose and Insulin Levels in Under-Weight Pregnant and Lactating Women with Preeclampsia
CONCLUSION: Intake of the LNS-PLW by pre-eclamptic women had short-term suppression on subsequent meal but improved total energy intake during trial.PMID:38206092 | PMC:PMC10830442 | DOI:10.1042/BSR20231344 (Source: Bioscience Reports)
Source: Bioscience Reports - January 11, 2024 Category: Biomedical Science Authors: Nabila Sher Mohammad Rubina Nazli Sadia Fatima Fozia Fozia Hafza Zafar Mashal Zafar Zarghuna Zafar Warda Khan Mahmoud M A Abulmeaty Dara Aldisi Juan E Andrade Laborde Mourad A M Aboul-Soud Source Type: research
A promise for neuronal repair: reprogramming astrocytes into neurons in vivo
This article provides a comprehensive review of reprogramming, including the selection and methods of reprogramming starting cell populations as well as the signaling methods involved in this process. Additionally, we thoroughly examine how reprogramming astrocytes into neurons can be applied to treat stroke and other neurodegenerative diseases. Finally, we discuss the challenges of neuronal reprogramming and offer insights about the field.PMID:38175538 | PMC:PMC10830445 | DOI:10.1042/BSR20231717 (Source: Bioscience Reports)
Source: Bioscience Reports - January 4, 2024 Category: Biomedical Science Authors: Lijuan Huang Xinyu Lai Xiaojun Liang Jiafeng Chen Yue Yang Wei Xu Qingchun Qin Rongxing Qin Xiaoying Huang Minshan Xie Li Chen Source Type: research
A Promise for Neuronal Repair: Reprogramming Astrocytes into Neurons in Vivo
This article provides a comprehensive review of reprogramming, including the selection and methods of reprogramming starting cell populations as well as the signaling methods involved in this process. Additionally, we thoroughly examine how reprogramming astrocytes into neurons can be applied to treat stroke and other neurodegenerative diseases. Finally, we discuss the challenges of neuronal reprogramming and offer insights about the field.PMID:38175538 | DOI:10.1042/BSR20231717 (Source: Bioscience Reports)
Source: Bioscience Reports - January 4, 2024 Category: Biomedical Science Authors: Lijuan Huang Xinyu Lai Xiaojun Liang Jiafeng Chen Yue Yang Wei Xu Qingchun Qin Rongxing Qin Xiaoying Huang Minshan Xie Li Chen Source Type: research
A Promise for Neuronal Repair: Reprogramming Astrocytes into Neurons in Vivo
This article provides a comprehensive review of reprogramming, including the selection and methods of reprogramming starting cell populations as well as the signaling methods involved in this process. Additionally, we thoroughly examine how reprogramming astrocytes into neurons can be applied to treat stroke and other neurodegenerative diseases. Finally, we discuss the challenges of neuronal reprogramming and offer insights about the field.PMID:38175538 | DOI:10.1042/BSR20231717 (Source: Bioscience Reports)
Source: Bioscience Reports - January 4, 2024 Category: Biomedical Science Authors: Lijuan Huang Xinyu Lai Xiaojun Liang Jiafeng Chen Yue Yang Wei Xu Qingchun Qin Rongxing Qin Xiaoying Huang Minshan Xie Li Chen Source Type: research
A Promise for Neuronal Repair: Reprogramming Astrocytes into Neurons in Vivo
This article provides a comprehensive review of reprogramming, including the selection and methods of reprogramming starting cell populations as well as the signaling methods involved in this process. Additionally, we thoroughly examine how reprogramming astrocytes into neurons can be applied to treat stroke and other neurodegenerative diseases. Finally, we discuss the challenges of neuronal reprogramming and offer insights about the field.PMID:38175538 | DOI:10.1042/BSR20231717 (Source: Bioscience Reports)
Source: Bioscience Reports - January 4, 2024 Category: Biomedical Science Authors: Lijuan Huang Xinyu Lai Xiaojun Liang Jiafeng Chen Yue Yang Wei Xu Qingchun Qin Rongxing Qin Xiaoying Huang Minshan Xie Li Chen Source Type: research
A Promise for Neuronal Repair: Reprogramming Astrocytes into Neurons in Vivo
This article provides a comprehensive review of reprogramming, including the selection and methods of reprogramming starting cell populations as well as the signaling methods involved in this process. Additionally, we thoroughly examine how reprogramming astrocytes into neurons can be applied to treat stroke and other neurodegenerative diseases. Finally, we discuss the challenges of neuronal reprogramming and offer insights about the field.PMID:38175538 | DOI:10.1042/BSR20231717 (Source: Bioscience Reports)
Source: Bioscience Reports - January 4, 2024 Category: Biomedical Science Authors: Lijuan Huang Xinyu Lai Xiaojun Liang Jiafeng Chen Yue Yang Wei Xu Qingchun Qin Rongxing Qin Xiaoying Huang Minshan Xie Li Chen Source Type: research
Biological ammonium transporters from the Amt/Mep/Rh superfamily: mechanism, energetics, and technical limitations
Biosci Rep. 2023 Dec 22:BSR20211209. doi: 10.1042/BSR20211209. Online ahead of print.ABSTRACTThe exchange of ammonium across cellular membranes is a fundamental process in all domains of life and is facilitated by the ubiquitous Amt/Mep/Rh transporter superfamily. Remarkably, despite a high structural conservation in all domains of life, these proteins have gained various biological functions during evolution. It is tempting to hypothesise that the physiological functions gained by these proteins may be explained at least in part by differences in the energetics of their translocation mechanisms. Therefore, in this review,...
Source: Bioscience Reports - December 22, 2023 Category: Biomedical Science Authors: Gordon Williamson Adriana Bizior Thomas Harris Leighton Pritchard Paul Alan Hoskisson Arnaud Javelle Source Type: research
Metabolic hormones are integral regulators of female reproductive health and function
Biosci Rep. 2023 Dec 22:BSR20231916. doi: 10.1042/BSR20231916. Online ahead of print.ABSTRACTThe female reproductive system is strongly influenced by nutrition and energy balance. It is well known that food restriction or energy depletion can induce suppression of reproductive processes, while overnutrition is associated with reproductive dysfunction. However, the intricate mechanisms through which nutritional inputs and metabolic health are integrated into the coordination of reproduction are still being defined. In this review, we describe evidence for essential contributions by hormones that are responsive to food intak...
Source: Bioscience Reports - December 22, 2023 Category: Biomedical Science Authors: Faria Athar Muskan Karmani Nicole M Templeman Source Type: research
Biological and mutational analyses of CXCR4-antagonist interactions and design of new antagonistic analogs
Biosci Rep. 2023 Dec 22;43(12):BSR20230981. doi: 10.1042/BSR20230981.ABSTRACTThe chemokine receptor CXCR4 has become an attractive therapeutic target for HIV-1 infection, hematopoietic stem cell mobilization, and cancer metastasis. A wide variety of synthetic antagonists of CXCR4 have been developed and studied for a growing list of clinical applications. To compare the biological effects of different antagonists on CXCR4 functions and their common and/or distinctive molecular interactions with the receptor, we conducted head-to-head comparative cell-based biological and mutational analyses of the interactions with CXCR4 o...
Source: Bioscience Reports - December 22, 2023 Category: Biomedical Science Authors: Qian Meng Ruohan Zhu Yujia Mao Siyu Zhu Yi Wu Lina S M Huang Aaron Ciechanover Jing An Yan Xu Ziwei Huang Source Type: research
Retraction: Long non-coding RNA FENDRR inhibits migration and invasion of cutaneous malignant melanoma cells
Biosci Rep. 2023 Dec 22;43(12):BSR-2019-1194_RET. doi: 10.1042/BSR-2019-1194_RET.NO ABSTRACTPMID:38131306 | DOI:10.1042/BSR-2019-1194_RET (Source: Bioscience Reports)
Source: Bioscience Reports - December 22, 2023 Category: Biomedical Science Source Type: research
SARS-CoV-2 NSP14 MTase activity is critical for inducing canonical NF- κB activation
Biosci Rep. 2023 Dec 22:BSR20231418. doi: 10.1042/BSR20231418. Online ahead of print.ABSTRACTUpon SARS-CoV-2 infection, patients with severe forms of COVID-19 often suffer from a dysregulated immune response and hyperinflammation. Aberrant expression of cytokines and chemokines is associated with strong activation of the immunoregulatory transcription factor NF-κB, which can be directly induced by the SARS-CoV-2 protein NSP14. Here, we use NSP14 mutants and generated cells with host factor knockouts (KO) in the NF-κB signaling pathways to characterize the molecular mechanism of NSP14-induced NF-κB activation. We demonst...
Source: Bioscience Reports - December 22, 2023 Category: Biomedical Science Authors: Marie J Tofaute Benjamin Weller Carina Gra ß Hridi Halder Bushra Dohai Pascal Falter-Braun Daniel Krappmann Source Type: research
Biological ammonium transporters from the Amt/Mep/Rh superfamily: mechanism, energetics, and technical limitations
Biosci Rep. 2023 Dec 22:BSR20211209. doi: 10.1042/BSR20211209. Online ahead of print.ABSTRACTThe exchange of ammonium across cellular membranes is a fundamental process in all domains of life and is facilitated by the ubiquitous Amt/Mep/Rh transporter superfamily. Remarkably, despite a high structural conservation in all domains of life, these proteins have gained various biological functions during evolution. It is tempting to hypothesise that the physiological functions gained by these proteins may be explained at least in part by differences in the energetics of their translocation mechanisms. Therefore, in this review,...
Source: Bioscience Reports - December 22, 2023 Category: Biomedical Science Authors: Gordon Williamson Adriana Bizior Thomas Harris Leighton Pritchard Paul Alan Hoskisson Arnaud Javelle Source Type: research
Metabolic hormones are integral regulators of female reproductive health and function
Biosci Rep. 2023 Dec 22:BSR20231916. doi: 10.1042/BSR20231916. Online ahead of print.ABSTRACTThe female reproductive system is strongly influenced by nutrition and energy balance. It is well known that food restriction or energy depletion can induce suppression of reproductive processes, while overnutrition is associated with reproductive dysfunction. However, the intricate mechanisms through which nutritional inputs and metabolic health are integrated into the coordination of reproduction are still being defined. In this review, we describe evidence for essential contributions by hormones that are responsive to food intak...
Source: Bioscience Reports - December 22, 2023 Category: Biomedical Science Authors: Faria Athar Muskan Karmani Nicole M Templeman Source Type: research
