Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis
CONCLUSION: LAT1 supports the regeneration of acinar cells after AP. Female mice lacking LAT1 exhibited more pronounced alterations than male mice, indicating a sexual dimorphism of amino acid metabolism.PMID:35431492 | PMC:PMC8968515 | DOI:10.3748/wjg.v28.i10.1024 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 18, 2022 Category: Gastroenterology Authors: Cristina M Hagen Eva Roth Theresia Reding Graf Fran çois Verrey Rolf Graf Anurag Gupta Giovanni Pellegrini Nad ège Poncet Simone Mafalda Rodrigues Camargo Source Type: research

Successful treatment of an enormous rectal mucosa-associated lymphoid tissue lymphoma by endoscopic full-thickness resection: A case report
CONCLUSION: This case provides new information on the specific endoscopic features of colorectal MALToma and an alternative treatment for patients.PMID:35431493 | PMC:PMC8968516 | DOI:10.3748/wjg.v28.i10.1078 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 18, 2022 Category: Gastroenterology Authors: Fang-Yuan Li Xiao-Long Zhang Qi-De Zhang Yao-Hui Wang Source Type: research

Malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer
World J Gastroenterol. 2022 Mar 14;28(10):985-1008. doi: 10.3748/wjg.v28.i10.985.ABSTRACTMalignant biliary obstruction generally results from primary malignancies of the pancreatic head, bile duct, gallbladder, liver, and ampulla of Vater. Metastatic lesions from other primaries to these organs or nearby lymph nodes are rarer causes of biliary obstruction. The most common primaries include renal cancer, lung cancer, gastric cancer, colorectal cancer, breast cancer, lymphoma, and melanoma. They may be difficult to differentiate from primary hepato-pancreato-biliary cancer based on imaging studies, or even on biopsy. There i...
Source: World Journal of Gastroenterology - April 18, 2022 Category: Gastroenterology Authors: Takeshi Okamoto Source Type: research

Comment "Asymptomatic small intestinal ulcerative lesions: Obesity and < em > Helicobacter pylori < /em > are likely to be risk factors"
World J Gastroenterol. 2022 Mar 14;28(10):1085-1087. doi: 10.3748/wjg.v28.i10.1085.ABSTRACTThere are many causes of anemia. It is unreasonable to simply associate anemia with asymptomatic ulcers in the small intestine.PMID:35431495 | PMC:PMC8968518 | DOI:10.3748/wjg.v28.i10.1085 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 18, 2022 Category: Gastroenterology Authors: Wei Wang Zhi-Peng Li Juan Zhang Zi-Jun Lin Mei-Lin Ma Si-Si Chen Source Type: research

An update on the diagnosis of gastroenteropancreatic neuroendocrine neoplasms
World J Gastroenterol. 2022 Mar 14;28(10):1009-1023. doi: 10.3748/wjg.v28.i10.1009.ABSTRACTGastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) arise from neuroendocrine cells found throughout the gastrointestinal tract and islet cells of the pancreas. The incidence and prevalence of GEP-NENs have been increasing each year due to higher awareness, improved diagnostic modalities, and increased incidental detection on cross-sectional imaging and endoscopy for cancer screening and other conditions and symptoms. GEP-NENs are a heterogeneous group of tumors and have a wide range in clinical presentation, histopathologic f...
Source: World Journal of Gastroenterology - April 18, 2022 Category: Gastroenterology Authors: Jiayun M Fang Jay Li Jiaqi Shi Source Type: research

Gut dysbiosis and small intestinal bacterial overgrowth as independent forms of gut microbiota disorders in cirrhosis
CONCLUSION: Despite the differences observed in the gut microbiome between patients with and without SIBO, gut dysbiosis and SIBO are most likely independent disorders of gut microbiota in cirrhosis.PMID:35431497 | PMC:PMC8968519 | DOI:10.3748/wjg.v28.i10.1067 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 18, 2022 Category: Gastroenterology Authors: Roman Maslennikov Vladimir Ivashkin Irina Efremova Elena Poluektova Anna Kudryavtseva George Krasnov Source Type: research

Diagnostic performance of endoscopic classifications for neoplastic lesions in patients with ulcerative colitis: A retrospective case-control study
CONCLUSION: The accuracy of endoscopic diagnosis using both classifications was lower for UCAN than for SN. Endoscopic diagnosis of UCAN tended to be underestimated compared with the pathological results.PMID:35431498 | PMC:PMC8968517 | DOI:10.3748/wjg.v28.i10.1055 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 18, 2022 Category: Gastroenterology Authors: Yuichi Kida Takeshi Yamamura Keiko Maeda Tsunaki Sawada Eri Ishikawa Yasuyuki Mizutani Naomi Kakushima Kazuhiro Furukawa Takuya Ishikawa Eizaburo Ohno Hiroki Kawashima Masanao Nakamura Masatoshi Ishigami Mitsuhiro Fujishiro Source Type: research

Feasibility of therapeutic endoscopic ultrasound in the bridge-to-surgery scenario: The example of pancreatic adenocarcinoma
World J Gastroenterol. 2022 Mar 14;28(10):976-984. doi: 10.3748/wjg.v28.i10.976.ABSTRACTUpfront resection is becoming a rarer indication for pancreatic ductal adenocarcinoma, as biologic behavior and natural history of the disease has boosted indications for neoadjuvant treatments. Jaundice, gastric outlet obstruction and acute cholecystitis can frequently complicate this window of opportunity, resulting in potentially deleterious chemotherapy discontinuation, whose resumption relies on effective, prompt and long-lasting management of these complications. Although therapeutic endoscopic ultrasound (t-EUS) can potentially o...
Source: World Journal of Gastroenterology - April 18, 2022 Category: Gastroenterology Authors: Giuseppe Vanella Domenico Tamburrino Gabriele Capurso Michiel Bronswijk Michele Reni Giuseppe Dell'Anna Stefano Crippa Schalk Van der Merwe Massimo Falconi Paolo Giorgio Arcidiacono Source Type: research

Quercetin exerts anti-inflammatory effects < em > via < /em > inhibiting tumor necrosis factor- α-induced matrix metalloproteinase-9 expression in normal human gastric epithelial cells
CONCLUSION: Quercetin significantly downregulates TNF-α-induced MMP-9 expression in GES-1 cells via the TNFR-c-Src-ERK1/2 and c-Fos or NF-κB pathways.PMID:35431500 | PMC:PMC8985486 | DOI:10.3748/wjg.v28.i11.1139 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 18, 2022 Category: Gastroenterology Authors: Hsi-Lung Hsieh Ming-Chin Yu Li-Ching Cheng Mei-Yi Chu Tzu-Hao Huang Ta-Sen Yeh Ming-Ming Tsai Source Type: research

Impaired coagulation, liver dysfunction and COVID-19: Discovering an intriguing relationship
World J Gastroenterol. 2022 Mar 21;28(11):1102-1112. doi: 10.3748/wjg.v28.i11.1102.ABSTRACTCoronavirus disease 2019 (COVID-19) is, at present, one of the most relevant global health problems. In the literature hepatic alterations have been described in COVID-19 patients, and they are mainly represented by worsening of underlying chronic liver disease leading to hepatic decompensation and liver failure with higher mortality. Several potential mechanisms used by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to cause liver damage have been hypothesized. COVID-19 primary liver injury is less common than secondar...
Source: World Journal of Gastroenterology - April 18, 2022 Category: Gastroenterology Authors: Damiano D'Ardes Andrea Boccatonda Giulio Cocco Stefano Fabiani Ilaria Rossi Marco Bucci Maria Teresa Guagnano Cosima Schiavone Francesco Cipollone Source Type: research

New treatment for gastroesophageal reflux disease: Traditional Chinese medicine Xiaochaihu decoction
World J Gastroenterol. 2022 Mar 21;28(11):1184-1186. doi: 10.3748/wjg.v28.i11.1184.ABSTRACTGastroesophageal reflux disease (GERD) has a high prevalence worldwide. Li et al performed a well-designed study on the efficacy of modified Xiaochaihu decoction (MXD) for GERD, which showed that MXD is an optional therapy for GERD beyond proton pump inhibitors (PPIs). The herbal granule administration mode minimized the bias from traditional herbal formula in clinical trials. One limitation of that study was that it lacked records of side effects and rescue medication. As a chronic disease with recurrent symptoms, GERD rehabilitatio...
Source: World Journal of Gastroenterology - April 18, 2022 Category: Gastroenterology Authors: Li-Ying Xu Bin-Yan Yu Lu-Sha Cen Source Type: research

Advanced imaging and artificial intelligence for Barrett's esophagus: What we should and soon will do
World J Gastroenterol. 2022 Mar 21;28(11):1113-1122. doi: 10.3748/wjg.v28.i11.1113.ABSTRACTBarrett's esophagus (BE) is a well-established risk factor for esophageal adenocarcinoma. It is recommended that patients have regular endoscopic surveillance, with the ultimate goal of detecting early-stage neoplastic lesions before they can progress to invasive carcinoma. Detection of both dysplasia or early adenocarcinoma permits curative endoscopic treatments, and with this aim, thorough endoscopic assessment is crucial and improves outcomes. The burden of missed neoplasia in BE is still far from being negligible, likely due to i...
Source: World Journal of Gastroenterology - April 18, 2022 Category: Gastroenterology Authors: Marco Spadaccini Edoardo Vespa Viveksandeep Thoguluva Chandrasekar Madhav Desai Harsh K Patel Roberta Maselli Alessandro Fugazza Silvia Carrara Andrea Anderloni Gianluca Franchellucci Alessandro De Marco Cesare Hassan Pradeep Bhandari Prateek Sharma Aless Source Type: research

B cells in pancreatic cancer stroma
World J Gastroenterol. 2022 Mar 21;28(11):1088-1101. doi: 10.3748/wjg.v28.i11.1088.ABSTRACTPancreatic cancer is a disease with high unmet clinical need. Pancreatic cancer is also characterised by an intense fibrotic stroma, which harbours many immune cells. Studies in both human and animal models have demonstrated that the immune system plays a crucial role in modulating tumour onset and progression. In human pancreatic ductal adenocarcinoma, high B-cell infiltration correlates with better patient survival. Hence, B cells have received recent interest in pancreatic cancer as potential therapeutic targets. However, the data...
Source: World Journal of Gastroenterology - April 18, 2022 Category: Gastroenterology Authors: Francesca Romana Delvecchio Michelle R Goulart Rachel Elizabeth Ann Fincham Michele Bombadieri Hemant M Kocher Source Type: research

Real-world effectiveness of direct-acting antivirals in people living with human immunodeficiency virus and hepatitis C virus genotype 6 infections
CONCLUSION: Similar to the observation made in HIV-negative patients, sustained virologic response 12 wk off-therapy with DAAs is high in PLWH coinfected with HCV-6.PMID:35431505 | PMC:PMC8985481 | DOI:10.3748/wjg.v28.i11.1172 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 18, 2022 Category: Gastroenterology Authors: Hsin-Yun Sun Chien-Yu Cheng Chi-Ying Lin Chia-Jui Yang Nan-Yao Lee Bo-Huang Liou Hung-Jen Tang Yuang-Meng Liu Chun-Yuan Lee Tun-Chieh Chen Yi-Chia Huang Yuan-Ti Lee Ming-Jui Tsai Po-Liang Lu Hung-Chin Tsai Ning-Chi Wang Tung-Che Hung Shu-Hsing Cheng Chien Source Type: research

Assessment of pathogens and risk factors associated with bloodstream infection in the year after pediatric liver transplantation
CONCLUSION: BSI was frequently observed in patients after pediatric LT, affecting survival outcomes. The profile of BSI may inform clinical treatment and management in high-risk children after LT.PMID:35431506 | PMC:PMC8985487 | DOI:10.3748/wjg.v28.i11.1159 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 18, 2022 Category: Gastroenterology Authors: Yeong Eun Kim Ho Jung Choi Hye-Jin Lee Hyun Ju Oh Mi Kyoung Ahn Seak Hee Oh Jung-Man Namgoong Dae Yeon Kim Won Kyoung Jhang Seong Jong Park Dong-Hwan Jung Deok Bog Moon Gi-Won Song Gil-Chun Park Tae-Yong Ha Chul-Soo Ahn Ki-Hun Kim Shin Hwang Sung Gyu Lee Source Type: research