Liquid biopsy for gastric cancer: Techniques, applications, and future directions
World J Gastroenterol. 2024 Mar 28;30(12):1680-1705. doi: 10.3748/wjg.v30.i12.1680.ABSTRACTAfter the study of circulating tumor cells in blood through liquid biopsy (LB), this technique has evolved to encompass the analysis of multiple materials originating from the tumor, such as nucleic acids, extracellular vesicles, tumor-educated platelets, and other metabolites. Additionally, research has extended to include the examination of samples other than blood or plasma, such as saliva, gastric juice, urine, or stool. LB techniques are diverse, intricate, and variable. They must be highly sensitive, and pre-analytical, patient...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Cristina D íaz Del Arco M Jes ús Fernández Aceñero Luis Ortega Medina Source Type: research
Interaction between diet and genetics in patients with inflammatory bowel disease
In conclusion, IBD is a complex and heterogeneous disease, and future studies are needed to elucidate the influence of epigenetics on diet and microbiota in IBD patients.PMID:38617734 | PMC:PMC11008370 | DOI:10.3748/wjg.v30.i12.1644 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Dani éla Oliveira Magro Ligia Yukie Sassaki J úlio Maria Fonseca Chebli Source Type: research
Gut microbiota and female health
World J Gastroenterol. 2024 Mar 28;30(12):1655-1662. doi: 10.3748/wjg.v30.i12.1655.ABSTRACTThe gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological pathways. Recent advancements underscore the critical role of gut microbial homeostasis in female health; with dysbiosis potentially leading to diseases among women such as polycystic ovarian syndrome, endometriosis, breast cancer, cervical cancer, and ovarian cancer etc. Despite this, there has been limited discussion on the underlying mechanisms. This editorial explores the three potential mechanisms throug...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Meng-Yao Wang Li-Xuan Sang Si-Yu Sun Source Type: research
Early proactive monitoring of DNA-thioguanine in patients with Crohn's disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers
CONCLUSION: Proactive therapeutic drug monitoring of DNATG could be an effective strategy to prevent late leucopenia in both NUDT15/TPMT normal and intermediate metabolizers with CD, especially the former.PMID:38617736 | PMC:PMC11008375 | DOI:10.3748/wjg.v30.i12.1751 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Ting Yang Kang Chao Xia Zhu Xue-Ding Wang Sumyuet Chan Yan-Ping Guan Jing Mao Pan Li Shao-Xing Guan Wen Xie Xiang Gao Min Huang Source Type: research
Hepatic recompensation according to Baveno VII criteria < em > via < /em > transjugular intrahepatic portosystemic shunt
World J Gastroenterol. 2024 Mar 28;30(12):1777-1779. doi: 10.3748/wjg.v30.i12.1777.ABSTRACTTransjugular intrahepatic portosystemic shunt is a therapeutic modality done through interventional radiology. It is aimed to decrease portal pressure in special situations for patients with decompensated liver disease with portal hypertension. It represents a potential addition to the therapeutic modalities that could achieve hepatic recompensation in those patients based on Baveno VII criteria.PMID:38617737 | PMC:PMC11008372 | DOI:10.3748/wjg.v30.i12.1777 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Hossam Eldin Shaaban Abeer Abdellatef Hussein Hassan Okasha Source Type: research
Endoscopic treatment of scarred polyps with a non-thermal device (Endorotor): A review of the literature
World J Gastroenterol. 2024 Mar 28;30(12):1706-1713. doi: 10.3748/wjg.v30.i12.1706.ABSTRACTEndoscopic resection (ER) of colorectal polyps has become a daily practice in most endoscopic units providing a colorectal cancer screening program and requires the availability of local experts and high-end endoscopic devices. ER procedures have evolved over the past few years from endoscopic mucosal resection (EMR) to more advanced techniques, such as endoscopic submucosal dissection and endo-scopic full-thickness resection. Complete resection and disease eradication are the ultimate goals of ER-based techniques, and novel devices ...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Mariam Zaghloul Hameed Rehman Stefano Sansone Konstantinos Argyriou Adolfo Parra-Blanco Source Type: research
Treatment patterns and survival outcomes in patients with non-metastatic early-onset pancreatic cancer
CONCLUSION: AT improves postoperative survival in localized patients. Surgery after NAT and RCT are the preferred therapeutic options for patients with locally advanced EOPC.PMID:38617739 | PMC:PMC11008379 | DOI:10.3748/wjg.v30.i12.1739 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Le-Tian Zhang Ying Zhang Bi-Yang Cao Chen-Chen Wu Jing Wang Source Type: research
New direction for surgery: Super minimally invasive surgery
In this study, I describe the origin, definition, operative channels, advantages, and future perspectives of SMIS.PMID:38617740 | PMC:PMC11008381 | DOI:10.3748/wjg.v30.i12.1676 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: En-Qiang Linghu Source Type: research
< em > ALKBH5 < /em > suppresses autophagic flux < em > via < /em > N6-methyladenosine demethylation of < em > ZKSCAN3 < /em > mRNA in acute pancreatitis
CONCLUSION: ALKBH5 inhibits autophagic flux through m6A demethylation of ZKSCAN3 mRNA in AP, thereby aggravating the severity of the disease.PMID:38617741 | PMC:PMC11008368 | DOI:10.3748/wjg.v30.i12.1764 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Tao Zhang Shuai Zhu Geng-Wen Huang Source Type: research
Assessing recent recurrence after hepatectomy for hepatitis B-related hepatocellular carcinoma by a predictive model based on sarcopenia
CONCLUSION: Sarcopenia is associated with recent recurrence after hepatectomy for hepatitis B-related HCC. A nutritional status-based prediction model is first established for postoperative recurrence of hepatitis B-related HCC, which is superior to other models and contributes to prognosis prediction.PMID:38617742 | PMC:PMC11008376 | DOI:10.3748/wjg.v30.i12.1727 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Hong Peng Si-Yi Lei Wei Fan Yu Dai Yi Zhang Gen Chen Ting-Ting Xiong Tian-Zhao Liu Yue Huang Xiao-Feng Wang Jin-Hui Xu Xin-Hua Luo Source Type: research
Multiparametric ultrasound as a new concept of assessment of liver tissue damage
World J Gastroenterol. 2024 Mar 28;30(12):1663-1669. doi: 10.3748/wjg.v30.i12.1663.ABSTRACTLiver disease accounts for approximately 2 million deaths per year worldwide. All chronic liver diseases (CLDs), whether of toxic, genetic, autoimmune, or infectious origin, undergo typical histological changes in the structure of the tissue. These changes may include the accumulation of extracellular matrix material, fats, triglycerides, or tissue scarring. Noninvasive methods for diagnosing CLD, such as conventional B-mode ultrasound (US), play a significant role in diagnosis. Doppler US, when coupled with B-mode US, can be helpful...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Angela Peltec Ioan Sporea Source Type: research
Pediatric stricturing Crohn's disease
World J Gastroenterol. 2024 Mar 28;30(12):1651-1654. doi: 10.3748/wjg.v30.i12.1651.ABSTRACTCrohn's disease (CD) is a chronic inflammatory disease of the digestive tract. The incidence of pediatric CD is increasing and is currently 2.5-11.4 per 100000 world-wide. Notably, approximately 25% of children with CD develop stricturing CD (SCD) that requires intervention. Symptomatic stricturing diseases refractory to pharmacological management frequently require non-pharmacological interventions. Non-pharmacological therapeutic strategies include endoscopic balloon dilatation, stricturoplasty, and surgical resection of the strict...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Alessandro Boscarelli Matteo Bramuzzo Source Type: research
Predictive value of red blood cell distribution width and hematocrit for short-term outcomes and prognosis in colorectal cancer patients undergoing radical surgery
CONCLUSION: A higher preoperative RDW and lower hematocrit were associated with more postoperative complications. However, only hematocrit was an independent risk factor for OS and DFS in CRC patients who underwent radical surgery, while RDW was not.PMID:38617745 | PMC:PMC11008369 | DOI:10.3748/wjg.v30.i12.1714 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Dong Peng Zi-Wei Li Fei Liu Xu-Rui Liu Chun-Yi Wang Source Type: research
Advancements in medical treatment for pancreatic neuroendocrine tumors: A beacon of hope
World J Gastroenterol. 2024 Mar 28;30(12):1670-1675. doi: 10.3748/wjg.v30.i12.1670.ABSTRACTThis editorial highlights the remarkable advancements in medical treatment strategies for pancreatic neuroendocrine tumors (pan-NETs), emphasizing tailored approaches for specific subtypes. Cytoreductive surgery and somatostatin analogs (SSAs) play pivotal roles in managing tumors, while palliative options such as molecular targeted therapy, peptide receptor radionuclide therapy, and chemotherapy are reserved for SSA-refractory patients. Gastrinomas, insulinomas, glucagonomas, carcinoid tumors and VIPomas necessitate distinct thera-p...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Somdatta Giri Jayaprakash Sahoo Source Type: research
Effect of < em > Aspergillus niger < /em > prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet
CONCLUSION: This exploratory study conducted in a real-life setting revealed high adherence to the GFD. The AN-PEP treatment did not significantly reduce the overall GIP stool concentration. However, given the observation of a significantly lower prevalence of patients with severe symptoms in the AN-PEP arm, further clinical research is warranted.PMID:38617446 | PMC:PMC11008412 | DOI:10.3748/wjg.v30.i11.1545 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Juan Pablo Stefanolo Ver ónica Segura Martina Grizzuti Abel Heredia Isabel Comino Ana Florencia Costa Roberto Puebla Mar ía Paz Temprano Sonia Isabel Niveloni Gabriel de Diego Mar ía E Oregui Edgardo Gustavo Smecuol Mauricio C de Marzi Elena F Verd ú Source Type: research
