Early proactive monitoring of DNA-thioguanine in patients with Crohn's disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers
CONCLUSION: Proactive therapeutic drug monitoring of DNATG could be an effective strategy to prevent late leucopenia in both NUDT15/TPMT normal and intermediate metabolizers with CD, especially the former.PMID:38617736 | PMC:PMC11008375 | DOI:10.3748/wjg.v30.i12.1751 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Ting Yang Kang Chao Xia Zhu Xue-Ding Wang Sumyuet Chan Yan-Ping Guan Jing Mao Pan Li Shao-Xing Guan Wen Xie Xiang Gao Min Huang Source Type: research
Hepatic recompensation according to Baveno VII criteria < em > via < /em > transjugular intrahepatic portosystemic shunt
World J Gastroenterol. 2024 Mar 28;30(12):1777-1779. doi: 10.3748/wjg.v30.i12.1777.ABSTRACTTransjugular intrahepatic portosystemic shunt is a therapeutic modality done through interventional radiology. It is aimed to decrease portal pressure in special situations for patients with decompensated liver disease with portal hypertension. It represents a potential addition to the therapeutic modalities that could achieve hepatic recompensation in those patients based on Baveno VII criteria.PMID:38617737 | PMC:PMC11008372 | DOI:10.3748/wjg.v30.i12.1777 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Hossam Eldin Shaaban Abeer Abdellatef Hussein Hassan Okasha Source Type: research
Endoscopic treatment of scarred polyps with a non-thermal device (Endorotor): A review of the literature
World J Gastroenterol. 2024 Mar 28;30(12):1706-1713. doi: 10.3748/wjg.v30.i12.1706.ABSTRACTEndoscopic resection (ER) of colorectal polyps has become a daily practice in most endoscopic units providing a colorectal cancer screening program and requires the availability of local experts and high-end endoscopic devices. ER procedures have evolved over the past few years from endoscopic mucosal resection (EMR) to more advanced techniques, such as endoscopic submucosal dissection and endo-scopic full-thickness resection. Complete resection and disease eradication are the ultimate goals of ER-based techniques, and novel devices ...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Mariam Zaghloul Hameed Rehman Stefano Sansone Konstantinos Argyriou Adolfo Parra-Blanco Source Type: research
Treatment patterns and survival outcomes in patients with non-metastatic early-onset pancreatic cancer
CONCLUSION: AT improves postoperative survival in localized patients. Surgery after NAT and RCT are the preferred therapeutic options for patients with locally advanced EOPC.PMID:38617739 | PMC:PMC11008379 | DOI:10.3748/wjg.v30.i12.1739 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Le-Tian Zhang Ying Zhang Bi-Yang Cao Chen-Chen Wu Jing Wang Source Type: research
New direction for surgery: Super minimally invasive surgery
In this study, I describe the origin, definition, operative channels, advantages, and future perspectives of SMIS.PMID:38617740 | PMC:PMC11008381 | DOI:10.3748/wjg.v30.i12.1676 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: En-Qiang Linghu Source Type: research
< em > ALKBH5 < /em > suppresses autophagic flux < em > via < /em > N6-methyladenosine demethylation of < em > ZKSCAN3 < /em > mRNA in acute pancreatitis
CONCLUSION: ALKBH5 inhibits autophagic flux through m6A demethylation of ZKSCAN3 mRNA in AP, thereby aggravating the severity of the disease.PMID:38617741 | PMC:PMC11008368 | DOI:10.3748/wjg.v30.i12.1764 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Tao Zhang Shuai Zhu Geng-Wen Huang Source Type: research
Assessing recent recurrence after hepatectomy for hepatitis B-related hepatocellular carcinoma by a predictive model based on sarcopenia
CONCLUSION: Sarcopenia is associated with recent recurrence after hepatectomy for hepatitis B-related HCC. A nutritional status-based prediction model is first established for postoperative recurrence of hepatitis B-related HCC, which is superior to other models and contributes to prognosis prediction.PMID:38617742 | PMC:PMC11008376 | DOI:10.3748/wjg.v30.i12.1727 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Hong Peng Si-Yi Lei Wei Fan Yu Dai Yi Zhang Gen Chen Ting-Ting Xiong Tian-Zhao Liu Yue Huang Xiao-Feng Wang Jin-Hui Xu Xin-Hua Luo Source Type: research
Multiparametric ultrasound as a new concept of assessment of liver tissue damage
World J Gastroenterol. 2024 Mar 28;30(12):1663-1669. doi: 10.3748/wjg.v30.i12.1663.ABSTRACTLiver disease accounts for approximately 2 million deaths per year worldwide. All chronic liver diseases (CLDs), whether of toxic, genetic, autoimmune, or infectious origin, undergo typical histological changes in the structure of the tissue. These changes may include the accumulation of extracellular matrix material, fats, triglycerides, or tissue scarring. Noninvasive methods for diagnosing CLD, such as conventional B-mode ultrasound (US), play a significant role in diagnosis. Doppler US, when coupled with B-mode US, can be helpful...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Angela Peltec Ioan Sporea Source Type: research
Pediatric stricturing Crohn's disease
World J Gastroenterol. 2024 Mar 28;30(12):1651-1654. doi: 10.3748/wjg.v30.i12.1651.ABSTRACTCrohn's disease (CD) is a chronic inflammatory disease of the digestive tract. The incidence of pediatric CD is increasing and is currently 2.5-11.4 per 100000 world-wide. Notably, approximately 25% of children with CD develop stricturing CD (SCD) that requires intervention. Symptomatic stricturing diseases refractory to pharmacological management frequently require non-pharmacological interventions. Non-pharmacological therapeutic strategies include endoscopic balloon dilatation, stricturoplasty, and surgical resection of the strict...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Alessandro Boscarelli Matteo Bramuzzo Source Type: research
Predictive value of red blood cell distribution width and hematocrit for short-term outcomes and prognosis in colorectal cancer patients undergoing radical surgery
CONCLUSION: A higher preoperative RDW and lower hematocrit were associated with more postoperative complications. However, only hematocrit was an independent risk factor for OS and DFS in CRC patients who underwent radical surgery, while RDW was not.PMID:38617745 | PMC:PMC11008369 | DOI:10.3748/wjg.v30.i12.1714 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Dong Peng Zi-Wei Li Fei Liu Xu-Rui Liu Chun-Yi Wang Source Type: research
Advancements in medical treatment for pancreatic neuroendocrine tumors: A beacon of hope
World J Gastroenterol. 2024 Mar 28;30(12):1670-1675. doi: 10.3748/wjg.v30.i12.1670.ABSTRACTThis editorial highlights the remarkable advancements in medical treatment strategies for pancreatic neuroendocrine tumors (pan-NETs), emphasizing tailored approaches for specific subtypes. Cytoreductive surgery and somatostatin analogs (SSAs) play pivotal roles in managing tumors, while palliative options such as molecular targeted therapy, peptide receptor radionuclide therapy, and chemotherapy are reserved for SSA-refractory patients. Gastrinomas, insulinomas, glucagonomas, carcinoid tumors and VIPomas necessitate distinct thera-p...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Somdatta Giri Jayaprakash Sahoo Source Type: research
Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome
CONCLUSION: Our finding that increased expression of the 5-HT2B receptor contributes to visceral hyperalgesia by inducing TRPV1 expression in IBS-D patients provides important insights into the potential mechanisms underlying IBS-D-associated visceral hyperalgesia.PMID:38596485 | PMC:PMC11000090 | DOI:10.3748/wjg.v30.i10.1431 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 10, 2024 Category: Gastroenterology Authors: Zheng-Yang Li Yu-Qing Mao Qian Hua Yong-Hong Sun Hai-Yan Wang Xuan-Guang Ye Jing-Xian Hu Ya-Jie Wang Miao Jiang Source Type: research
Current considerations on intraductal papillary neoplasms of the bile duct and pancreatic duct
World J Gastroenterol. 2024 Mar 14;30(10):1461-1465. doi: 10.3748/wjg.v30.i10.1461.ABSTRACTPancreatobiliary intraductal papillary neoplasms (IPNs) represent precursors of pancreatic cancer or bile duct cholangiocarcinoma that can be detected and treated. Despite advances in diagnostic methods, identifying these premalignant lesions is still challenging for treatment providers. Modern imaging, biomarkers and molecular tests for genomic alterations can be used for diagnosis and follow-up. Surgical intervention in combination with new chemotherapeutic agents is considered the optimal treatment for malignant cases. The balance...
Source: World Journal of Gastroenterology - April 10, 2024 Category: Gastroenterology Authors: Efstathios T Pavlidis Ioannis N Galanis Theodoros E Pavlidis Source Type: research
Bridging the gap: Unveiling the crisis of physical inactivity in inflammatory bowel diseases
World J Gastroenterol. 2024 Mar 14;30(10):1261-1265. doi: 10.3748/wjg.v30.i10.1261.ABSTRACTIn this editorial we comment on the article titled "Inflammatory bowel diseases patients suffer from significant low levels and barriers to physical activity: The BE-FIT-IBD study" published in a recent issue of the World Journal of Gastroenterology 2023; 29 (41): 5668-5682. Inflammatory bowel diseases (IBD) are emerging as a significant global health concern as their incidence continues to rise on a global scale, with detrimental impacts on quality of life. While many advances have been made regarding the management of the disease, ...
Source: World Journal of Gastroenterology - April 10, 2024 Category: Gastroenterology Authors: Remus Stafie Ana-Maria Singeap Adrian Rotaru Carol Stanciu Anca Trifan Source Type: research
Alkaline sphingomyelinase deficiency impairs intestinal mucosal barrier integrity and reduces antioxidant capacity in dextran sulfate sodium-induced colitis
CONCLUSION: Alk-SMase regulates the stability of the intestinal mucosal barrier and enhances antioxidant activity through the Nrf2 signaling pathway.PMID:38596488 | PMC:PMC11000083 | DOI:10.3748/wjg.v30.i10.1405 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 10, 2024 Category: Gastroenterology Authors: Ye Tian Xin Li Xu Wang Si-Ting Pei Hong-Xin Pan Yu-Qi Cheng Yi-Chen Li Wen-Ting Cao Jin-Dong Ding Petersen Ping Zhang Source Type: research
