Recent advances in age-related metabolic dysfunction-associated steatotic liver disease
World J Gastroenterol. 2024 Feb 21;30(7):652-662. doi: 10.3748/wjg.v30.i7.652.ABSTRACTMetabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately 25% of the world's population and has become a leading cause of chronic liver disease. In recent years, an increasing amount of data suggests that MASLD is associated with aging. As the population ages, age-related MASLD will become a major global health problem. Targeting an aging will become a new approach to the treatment of MASLD. This paper reviews the current studies on the role of aging-related factors and therapeutic targets in MASLD, including:...
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Qian-Jun He Yi-Fei Li Ling-Tong Zhao Chun-Tong Lin Chun-Yan Yu Dan Wang Source Type: research
Colon and rectal cancer: An emergent public health problem
This study is a review of CRC pathology and includes the most recent scientific evidence regarding this pathology, as well as a diagnosis of the epidemiological situation of CRC. Finally, the recommendation from a public health perspective will be discussed in detail taking into account the context and the most current recommendations.PMID:38515957 | PMC:PMC10950624 | DOI:10.3748/wjg.v30.i7.644 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Marina Pinheiro David Nascimento Moreira Michele Ghidini Source Type: research
Muscle strength and non-alcoholic fatty liver disease/metabolic-associated fatty liver disease
World J Gastroenterol. 2024 Feb 21;30(7):636-643. doi: 10.3748/wjg.v30.i7.636.ABSTRACTThis editorial comments on an article published in a recent issue of World Journal of Gastroenterology, entitled "Association of low muscle strength with metabolic dysfunction-associated fatty liver disease: A nationwide study". We focused on the association between muscle strength and the incidence of non-alcoholic fatty liver disease (NAFLD) and metabolic-associated fatty liver disease (MAFLD), as well as the mechanisms underlying the correlation and related clinical applications. NAFLD, which is now redefined as MAFLD, is one of the mo...
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Xuan-Yu Hao Kai Zhang Xing-Yong Huang Fei Yang Si-Yu Sun Source Type: research
Monitoring of hepatocellular carcinoma
World J Gastroenterol. 2024 Feb 28;30(8):991-993. doi: 10.3748/wjg.v30.i8.991.ABSTRACTScreening for hepatocellular carcinoma in patients at risk is an evidence-based approach; however, adherence to the monitoring protocol recommended by international guidelines is difficult. Hence, there is a need to use the best scr-eening options and refine the selection of patients at risk in the future.PMID:38516232 | PMC:PMC10950649 | DOI:10.3748/wjg.v30.i8.991 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Imen Akkari Hanen Jaziri Source Type: research
Nonsteroidal anti-inflammatory drugs before endoscopic ultrasound guided tissue acquisition to reduce the incidence of post procedural pancreatitis
World J Gastroenterol. 2024 Feb 28;30(8):811-816. doi: 10.3748/wjg.v30.i8.811.ABSTRACTEndoscopic ultrasound (EUS) with fine needle aspiration or fine needle biopsy is the gold standard for sampling tissue to diagnose pancreatic cancer and autoimmune pancreatitis or to analyze cyst fluid. The most common reported adverse event of fine needle aspiration and/or fine needle biopsy is acute pancreatitis, which is likely induced by the same pathophysiological mechanisms as after endoscopic retrograde cholangiopancreatography (ERCP). According to the current European Society of Gastrointestinal Endoscopy guideline, nonsteroidal a...
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Mike de Jong Foke van Delft Christine Roozen Erwin-Jan van Geenen Tanya Bisseling Peter Siersema Marco Bruno Source Type: research
Management of autoimmune hepatitis induced by hepatitis delta virus
World J Gastroenterol. 2024 Feb 28;30(8):799-805. doi: 10.3748/wjg.v30.i8.799.ABSTRACTApproximately 12-72 million people worldwide are co-infected with hepatitis B virus (HBV) and hepatitis delta virus (HDV). This concurrent infection can lead to several severe outcomes with hepatic disease, such as cirrhosis, fulminant hepatitis, and hepatocellular carcinoma, being the most common. Over the past few decades, a correlation between viral hepatitis and autoimmune diseases has been reported. Furthermore, autoantibodies have been detected in the serum of patients co-infected with HBV/HDV, and autoimmune features have been repo...
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Eleni Gigi Vasileios Lagopoulos Aris Liakos Source Type: research
Adjuvant therapy for hepatocellular carcinoma: Dilemmas at the start of a new era
World J Gastroenterol. 2024 Feb 28;30(8):806-810. doi: 10.3748/wjg.v30.i8.806.ABSTRACTApproximately 50%-70% of patients with hepatocellular carcinoma experience recurrence within five years after curative hepatic resection or ablation. As a result, many patients receive adjuvant therapy after curative resection or ablation in order to prolong recurrence-free survival. The therapy recommended by national guidelines can differ, and guidelines do not specify when to initiate adjuvant therapy or how long to continue it. These and other unanswered questions around adjuvant therapies make it difficult to optimize them and determ...
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Jian-Hong Zhong Source Type: research
Cronkhite-Canada syndrome with esophagus involvement and six-year follow-up: A case report
CONCLUSION: Comprehensive treatment led by hormonal therapy can result in partial or full remission of clinical symptoms. Treatment should be individualized for each patient according to their therapy response. Surveillance endoscopy is necessary for assessing mucosal disease activity and detecting malignant transformation.PMID:38516236 | PMC:PMC10950646 | DOI:10.3748/wjg.v30.i8.984 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Yu-Chen Tang Source Type: research
Immunotherapy of gastric cancer: Present status and future perspectives
We describe the treatment of resectable tumors, locally advanced neoplasms, and unresectable (advanced) cases. Special attention is given to modern therapeutic approaches with emphasis on immunotherapy, which seems to be the future of GC treatment, especially in combination with chemotherapy. There is also a thorough analysis of the results of the study under review in terms of the number of scientific publications, the countries in which the studies were conducted, the authors, and the scientific centers of origin, as well as the clinical studies in progress. Finally, an attempt is made to draw some con-clusions and to po...
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: John K Triantafillidis Manousos M Konstadoulakis Apostolos E Papalois Source Type: research
Evaluating the influence of sarcopenia and myosteatosis on clinical outcomes in gastric cancer patients undergoing immune checkpoint inhibitor
CONCLUSION: The presence of sarcopenia or myosteatosis is a reliable predictor of the clinical outcomes of patients with GC who are undergoing treatment with an ICI.PMID:38516238 | PMC:PMC10950641 | DOI:10.3748/wjg.v30.i8.863 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Gui-Ming Deng Hai-Bin Song Zhong-Ze Du Ying-Wei Xue Hong-Jiang Song Yuan-Zhou Li Source Type: research
Bibliometrics analysis based on the Web of Science: Current trends and perspective of gastric organoid during 2010-2023
CONCLUSION: Key focus areas of research using gastric organoids include unraveling disease mechanisms and enhancing drug screening techniques. Major contributions from renowned academic institutions highlight this field's dynamic growth.PMID:38516239 | PMC:PMC10950634 | DOI:10.3748/wjg.v30.i8.969 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Kai-Lin Jiang Yue-Bo Jia Xue-Jiao Liu Qing-Ling Jia Li-Kun Guo Xiang-Xiang Wang Ke-Ming Yang Chen-Heng Wu Bei-Bei Liang Jiang-Hong Ling Source Type: research
Transcatheter arterial chemoembolization combined with PD-1 inhibitors and Lenvatinib for hepatocellular carcinoma with portal vein tumor thrombus
CONCLUSION: A triplet regimen of PTL was safe and well-tolerated as well as exhibited favorable efficacy over the TL regimen for advanced-stage HCC patients with PVTT types I-IV.PMID:38516240 | PMC:PMC10950640 | DOI:10.3748/wjg.v30.i8.843 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Hong-Xiao Wu Xiao-Yan Ding Ya-Wen Xu Ming-Hua Yu Xiao-Mi Li Na Deng Jing-Long Chen Source Type: research
Fecal microbiota transplantation for treatment of non-alcoholic fatty liver disease: Mechanism, clinical evidence, and prospect
World J Gastroenterol. 2024 Feb 28;30(8):833-842. doi: 10.3748/wjg.v30.i8.833.ABSTRACTThe population of non-alcoholic fatty liver disease (NAFLD) patients along with relevant advanced liver disease is projected to continue growing, because currently no medications are approved for treatment. Fecal microbiota transplantation (FMT) is believed a novel and promising therapeutic approach based on the concept of the gut-liver axis in liver disease. There has been an increase in the number of pre-clinical and clinical studies evaluating FMT in NAFLD treatment, however, existing findings diverge on its effects. Herein, we briefly...
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Xiao-Xia Qiu Sheng-Li Cheng Yan-Hui Liu Yu Li Rui Zhang Nan-Nan Li Zheng Li Source Type: research
Metadherin promotes stem cell phenotypes and correlated with immune infiltration in hepatocellular carcinoma
CONCLUSION: High levels of MTDH expression in patients with HCC are associated with poor prognosis, promoting tumor stemness, immune infiltration, and HCC progression.PMID:38516242 | PMC:PMC10950638 | DOI:10.3748/wjg.v30.i8.901 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Yi-Ying Wang Mei-Mei Shen Jian Gao Source Type: research
Lipid metabolism-related long noncoding RNA RP11-817I4.1 promotes fatty acid synthesis and tumor progression in hepatocellular carcinoma
CONCLUSION: LMR-lncRNAs have the capacity to predict the clinical characteristics and prognoses of HCC patients, and the discovery of a novel LMR-lncRNAs, RP11-817I4.1, revealed its role in promoting lipid accumulation, thereby accelerating the onset and progression of HCC.PMID:38516243 | PMC:PMC10950635 | DOI:10.3748/wjg.v30.i8.919 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Ren-Yong Wang Jia-Ling Yang Ning Xu Jia Xu Shao-Hua Yang Dao-Ming Liang Jin-Ze Li Hong Zhu Source Type: research
