Complementary comments on metastatic liver lesions with exceptional and rare cases
World J Gastroenterol. 2024 Feb 21;30(7):770-773. doi: 10.3748/wjg.v30.i7.770.ABSTRACTLiver metastases can appear in different forms in magnetic resonance imaging. Contrary to popular belief, while radiologists report hypovascular or hypervascular metastatic lesions, exceptional examples may be detected in various tumors. The aim of this article is to improve this review by presenting rare and atypical examples of liver metastasis, as well as cases that might potentially be misdiagnosed as metastases during the process of differential diagnosis.PMID:38515950 | PMC:PMC10950620 | DOI:10.3748/wjg.v30.i7.770 (Source: World Jou...
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Kemal Bugra Memis Sonay Aydin Source Type: research

Erlotinib combination with a mitochondria-targeted ubiquinone effectively suppresses pancreatic cancer cell survival
CONCLUSION: Our findings suggest that a combination of erlotinib and MitoQ has the potential to suppress pancreatic tumor cell viability effectively.PMID:38515951 | PMC:PMC10950623 | DOI:10.3748/wjg.v30.i7.714 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Pui-Yin Leung Wenjing Chen Anissa N Sari Poojitha Sitaram Pui-Kei Wu Susan Tsai Jong-In Park Source Type: research

Red cell distribution width/platelet ratio estimates the 3-year risk of decompensation in Metabolic Dysfunction-Associated Steatotic Liver Disease-induced cirrhosis
CONCLUSION: Altogether these findings suggest the RPR as a valid and potentially applicable non-invasive tool in the prediction of timing and modalities of decompensation in MASLD-related cACLD patients.PMID:38515952 | PMC:PMC10950628 | DOI:10.3748/wjg.v30.i7.685 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Marcello Dallio Mario Romeo Paolo Vaia Salvatore Auletta Simone Mammone Marina Cipullo Luigi Sapio Angela Ragone Marco Niosi Silvio Naviglio Alessandro Federico Source Type: research

Endoscopic ultrasonography-related diagnostic accuracy and clinical significance on small rectal neuroendocrine neoplasms
World J Gastroenterol. 2024 Feb 21;30(7):774-778. doi: 10.3748/wjg.v30.i7.774.ABSTRACTThis research aimed to examine the diagnostic accuracy and clinical significance of endoscopic ultrasonography (EUS) in the context of small rectal neuroendocrine neoplasms (NENs). A total of 108 patients with rectal subepithelial lesions (SELs) with a diameter of < 20 mm were included in the analysis. The diagnosis and depth assessment of EUS was compared to the histology findings. The prevalence of NENs in rectal SELs was 78.7% (85/108). The sensitivity of EUS in detecting rectal NENs was 98.9% (84/85), while the specificity was 52.2...
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Jun Weng Yu-Fan Chen Shu-Han Li Yan-Hua Lv Ruo-Bing Chen Guo-Liang Xu Shi-Yong Lin Kun-Hao Bai Source Type: research

Metformin and pancreatic neuroendocrine tumors: A systematic review and meta-analysis
CONCLUSION: T2DM represents a risk factor for the insurgence of pNET and is a significant predictor of poor post-treatment TFS of pNET patients. Unfortunately, a few studies with heterogeneous results limited the possibility of exploring the effect of metformin in the diagnosis and prognosis of pNET.PMID:38515954 | PMC:PMC10950617 | DOI:10.3748/wjg.v30.i7.759 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Maja Cigrovski Berkovic Alessandro Coppola Vibor Sesa Anna Mrzljak Quirino Lai Source Type: research

Endoscopic features and treatments of gastric cystica profunda
CONCLUSION: The findings suggested that endoscopic resection might serve as an effective and minimally invasive treatment for GCP with or without EGC.PMID:38515955 | PMC:PMC10950630 | DOI:10.3748/wjg.v30.i7.673 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Zi-Han Geng Yan Zhu Pei-Yao Fu Yi-Fan Qu Wei-Feng Chen Xia Yang Ping-Hong Zhou Quan-Lin Li Source Type: research

Recent advances in age-related metabolic dysfunction-associated steatotic liver disease
World J Gastroenterol. 2024 Feb 21;30(7):652-662. doi: 10.3748/wjg.v30.i7.652.ABSTRACTMetabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately 25% of the world's population and has become a leading cause of chronic liver disease. In recent years, an increasing amount of data suggests that MASLD is associated with aging. As the population ages, age-related MASLD will become a major global health problem. Targeting an aging will become a new approach to the treatment of MASLD. This paper reviews the current studies on the role of aging-related factors and therapeutic targets in MASLD, including:...
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Qian-Jun He Yi-Fei Li Ling-Tong Zhao Chun-Tong Lin Chun-Yan Yu Dan Wang Source Type: research

Colon and rectal cancer: An emergent public health problem
This study is a review of CRC pathology and includes the most recent scientific evidence regarding this pathology, as well as a diagnosis of the epidemiological situation of CRC. Finally, the recommendation from a public health perspective will be discussed in detail taking into account the context and the most current recommendations.PMID:38515957 | PMC:PMC10950624 | DOI:10.3748/wjg.v30.i7.644 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Marina Pinheiro David Nascimento Moreira Michele Ghidini Source Type: research

Muscle strength and non-alcoholic fatty liver disease/metabolic-associated fatty liver disease
World J Gastroenterol. 2024 Feb 21;30(7):636-643. doi: 10.3748/wjg.v30.i7.636.ABSTRACTThis editorial comments on an article published in a recent issue of World Journal of Gastroenterology, entitled "Association of low muscle strength with metabolic dysfunction-associated fatty liver disease: A nationwide study". We focused on the association between muscle strength and the incidence of non-alcoholic fatty liver disease (NAFLD) and metabolic-associated fatty liver disease (MAFLD), as well as the mechanisms underlying the correlation and related clinical applications. NAFLD, which is now redefined as MAFLD, is one of the mo...
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Xuan-Yu Hao Kai Zhang Xing-Yong Huang Fei Yang Si-Yu Sun Source Type: research

Monitoring of hepatocellular carcinoma
World J Gastroenterol. 2024 Feb 28;30(8):991-993. doi: 10.3748/wjg.v30.i8.991.ABSTRACTScreening for hepatocellular carcinoma in patients at risk is an evidence-based approach; however, adherence to the monitoring protocol recommended by international guidelines is difficult. Hence, there is a need to use the best scr-eening options and refine the selection of patients at risk in the future.PMID:38516232 | PMC:PMC10950649 | DOI:10.3748/wjg.v30.i8.991 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Imen Akkari Hanen Jaziri Source Type: research

Nonsteroidal anti-inflammatory drugs before endoscopic ultrasound guided tissue acquisition to reduce the incidence of post procedural pancreatitis
World J Gastroenterol. 2024 Feb 28;30(8):811-816. doi: 10.3748/wjg.v30.i8.811.ABSTRACTEndoscopic ultrasound (EUS) with fine needle aspiration or fine needle biopsy is the gold standard for sampling tissue to diagnose pancreatic cancer and autoimmune pancreatitis or to analyze cyst fluid. The most common reported adverse event of fine needle aspiration and/or fine needle biopsy is acute pancreatitis, which is likely induced by the same pathophysiological mechanisms as after endoscopic retrograde cholangiopancreatography (ERCP). According to the current European Society of Gastrointestinal Endoscopy guideline, nonsteroidal a...
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Mike de Jong Foke van Delft Christine Roozen Erwin-Jan van Geenen Tanya Bisseling Peter Siersema Marco Bruno Source Type: research

Management of autoimmune hepatitis induced by hepatitis delta virus
World J Gastroenterol. 2024 Feb 28;30(8):799-805. doi: 10.3748/wjg.v30.i8.799.ABSTRACTApproximately 12-72 million people worldwide are co-infected with hepatitis B virus (HBV) and hepatitis delta virus (HDV). This concurrent infection can lead to several severe outcomes with hepatic disease, such as cirrhosis, fulminant hepatitis, and hepatocellular carcinoma, being the most common. Over the past few decades, a correlation between viral hepatitis and autoimmune diseases has been reported. Furthermore, autoantibodies have been detected in the serum of patients co-infected with HBV/HDV, and autoimmune features have been repo...
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Eleni Gigi Vasileios Lagopoulos Aris Liakos Source Type: research

Adjuvant therapy for hepatocellular carcinoma: Dilemmas at the start of a new era
World J Gastroenterol. 2024 Feb 28;30(8):806-810. doi: 10.3748/wjg.v30.i8.806.ABSTRACTApproximately 50%-70% of patients with hepatocellular carcinoma experience recurrence within five years after curative hepatic resection or ablation. As a result, many patients receive adjuvant therapy after curative resection or ablation in order to prolong recurrence-free survival. The therapy recommended by national guidelines can differ, and guidelines do not specify when to initiate adjuvant therapy or how long to continue it. These and other unanswered questions around adjuvant therapies make it difficult to optimize them and determ...
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Jian-Hong Zhong Source Type: research

Cronkhite-Canada syndrome with esophagus involvement and six-year follow-up: A case report
CONCLUSION: Comprehensive treatment led by hormonal therapy can result in partial or full remission of clinical symptoms. Treatment should be individualized for each patient according to their therapy response. Surveillance endoscopy is necessary for assessing mucosal disease activity and detecting malignant transformation.PMID:38516236 | PMC:PMC10950646 | DOI:10.3748/wjg.v30.i8.984 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Yu-Chen Tang Source Type: research

Immunotherapy of gastric cancer: Present status and future perspectives
We describe the treatment of resectable tumors, locally advanced neoplasms, and unresectable (advanced) cases. Special attention is given to modern therapeutic approaches with emphasis on immunotherapy, which seems to be the future of GC treatment, especially in combination with chemotherapy. There is also a thorough analysis of the results of the study under review in terms of the number of scientific publications, the countries in which the studies were conducted, the authors, and the scientific centers of origin, as well as the clinical studies in progress. Finally, an attempt is made to draw some con-clusions and to po...
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: John K Triantafillidis Manousos M Konstadoulakis Apostolos E Papalois Source Type: research