Decrease in the number of patients diagnosed with cancer during the COVID-19 pandemic in Germany
ConclusionThe COVID-19 pandemic has been associated with a decrease in the number of patients newly diagnosed with cancer in general and specialized practices in Germany. Public health interventions are urgently warranted to mitigate the deleterious effects of this health crisis on cancer diagnosis. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 18, 2022 Category: Cancer & Oncology Source Type: research

Mammographic density to predict response to neoadjuvant systemic breast cancer therapy
ConclusionPatients with dense breast are more likely to attain a pCR at net of other predictive factors. The potential of MD to assist decisions on BC management and as a stratification factor in neoadjuvant clinical trials should be considered. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 17, 2022 Category: Cancer & Oncology Source Type: research

The role of leucine-rich alpha-2-glycoprotein-1 in proliferation, migration, and invasion of tumors
ConclusionsLRG1 are critical for the processes of tumorigenesis, development, and metastasis in various tumors. The present study reviewed the latest research on the achievements of LRG1 in tumor genesis and development. Further, this study also discussed the related molecular mechanisms of various biological functions of LRG1. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 17, 2022 Category: Cancer & Oncology Source Type: research

In vivo and in vitro inhibition of SCLC by combining dual cancer-specific recombinant adenovirus with Etoposide
ConclusionsThe above results indicate that when combined with Etoposide, Ad-VT may have an important role in synergistically inhibiting tumors. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 17, 2022 Category: Cancer & Oncology Source Type: research

Targeting PGC1 α to wrestle cancer: a compelling therapeutic opportunity
AbstractMetabolic adaptation is an emerging hallmark of cancer, as it provides tumor cells sufficient energy and metabolic intermediates. Although tumor cells are believed to highly rely on Warburg effect to satisfy their energy demand, more studies have pointed out that various types of tumor cells are highly dependent on oxidative phosphorylation to drive the tumorigenesis. Peroxisome proliferator-activated receptor-c coactivator 1 α (PGC1α), the crucial member of PGC1 family, is aberrantly expressed in several cancer types, implicating its role in tumor proliferation, migration, invasion, metastasis, and che...
Source: Journal of Cancer Research and Clinical Oncology - January 15, 2022 Category: Cancer & Oncology Source Type: research

Estrogen concentration and estrogen receptor- β expression in postmenopausal colon cancer considering patient/tumor background
AbstractPurposeA large number of studies have suggested an inhibitory role of estrogens against colorectal cancer (CRC), but persistent controversy exists. CRC characteristics are affected by sex, age, and tumor locus, suggesting the need for a systematic study considering these factors. The purpose of this study was to verify the difference in the pathobiological role of estrogens in CRC according to patient/tumor backgrounds.MethodsSurgical specimens from 116 postmenopausal women ( ≥ 70 years/o,n = 74; 
Source: Journal of Cancer Research and Clinical Oncology - January 15, 2022 Category: Cancer & Oncology Source Type: research

Acquired resistance to irradiation or docetaxel is not associated with cross-resistance to cisplatin in prostate cancer cell lines
ConclusionLike patients, different mCRPC cell lines exhibit significant variability regarding CDDP tolerance. The presented in vitro data suggest that previous radiation treatment may be associated with a moderate sensitization to CDDP in an isogenic and age-matched setting. Therefore, previous radiotherapy or docetaxel chemotherapy might be no contraindication against initiation of platinum chemotherapy in selected mCRPC patients. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 12, 2022 Category: Cancer & Oncology Source Type: research

Primary systemic therapy for patients with brain metastases from lung cancer ineligible for targeted agents
ConclusionIn patients ineligible for targeted agents, planned radiotherapy in a modern treatment setting was associated with longer survival compared to no radiotherapy. Timing and type of radiotherapy in such patients should be evaluated in prospective trials to identify patients who might not need planned radiotherapy. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 12, 2022 Category: Cancer & Oncology Source Type: research

Frequent FGFR1 hotspot alterations in driver-unknown low-grade glioma and mixed neuronal-glial tumors
ConclusionFGFR1 hotspot mutations are the fifth most prevailing alteration in LGG/MNGT. Performing FGFR1 sequencing analysis in driver-unknown low-grade brain tumors could yield up to 12% FGFR1 N546/K656 mutant cases. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 11, 2022 Category: Cancer & Oncology Source Type: research

Predictive values of mutational variant allele frequency in overall survival and leukemic progression of myelodysplastic syndromes
ConclusionOur study highlights that VAF of certain genes should be incorporated into routine clinical prognostication of survival and leukemic transformation  of MDS. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 10, 2022 Category: Cancer & Oncology Source Type: research

The pan-immune-inflammation value and systemic immune-inflammation index in advanced melanoma patients under immunotherapy
ConclusionsEven though both immune-inflammation biomarkers showed some power to differentiate between CM stages and HC, respectively, PIV and SII seem not to be significant predictors for clinical outcome measures of CM patients under ICI therapy. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 10, 2022 Category: Cancer & Oncology Source Type: research

Harnessing chlorin e6 loaded by functionalized iron oxide nanoparticles linked with glucose for target photodynamic therapy and improving of the immunogenicity of lung cancer
ConclusionIn conclusion, Ce6 loaded by functionalized iron oxide nanoparticles linked with glucose exhibited both target photodynamic efficacy and the ability to enhance its immunogenicity in lung cancer. This study provides a promising strategy for augment of the targeting delivery of Ce6 and its mediated photodynamic and immunotherapy. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 8, 2022 Category: Cancer & Oncology Source Type: research

CD147 expression lacks prognostic relevance in esophageal cancer
ConclusionThus, our data show that CD147 has no prognostic value, neither in esophageal adenocarcinoma nor squamous cell carcinoma. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 8, 2022 Category: Cancer & Oncology Source Type: research

Infiltrating T lymphocytes in the tumor microenvironment of small cell lung cancer: a state of knowledge review
AbstractImmune checkpoint inhibitors (ICIs) have brought new hope for the treatment of patients with small cell lung cancer (SCLC) over the past decades. However, the overall response rate is limited, and is lower than that in non-small cell lung cancer (NSCLC). This is in part because of the lack of pre-existing tumor-infiltrating T lymphocytes (TITLs), especially cytotoxic T cells (CTLs), in the SCLC tumor microenvironment (TME), resulting in insufficient anti-tumor immune response. To unleash the full potential of ICIs, the trafficking and infiltration of TITLs to the tumor is necessary and tightly regulated, the highly...
Source: Journal of Cancer Research and Clinical Oncology - January 8, 2022 Category: Cancer & Oncology Source Type: research

Prognostic value of hepatocyte growth factor for muscle-invasive bladder cancer
AbstractPurposeThe HGF/MET pathway is involved in cell motility, angiogenesis, proliferation, and cancer invasion. We assessed the clinical utility of plasma HGF level as a prognostic biomarker in patients with MIBC.MethodsWe retrospectively analyzed 565 patients with MIBC who underwent radical cystectomy. Logistic regression and Cox regression models were used, and predictive accuracies were estimated using the area under the curve and concordance index. To estimate the clinical utility of HGF, DCA and MCID were applied.ResultsPlasma HGF level was significantly higher in patients with advanced pathologic stage and LN meta...
Source: Journal of Cancer Research and Clinical Oncology - January 8, 2022 Category: Cancer & Oncology Source Type: research

Ultra-hypofractionated whole breast adjuvant radiotherapy in the real-world setting: single experience with 271 elderly/frail patients treated with 3D and IMRT technique
ConclusionsWeekly ultra-hypofractionated whole breast RT seems feasible and effective. Toxicity was mild, local control was acceptable, and overall survival was 97.8% at 3  years. Rates of severe toxicity were reduced with the IMRT technique. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 6, 2022 Category: Cancer & Oncology Source Type: research

Correction to: Inactivation of ICAM1 inhibits metastasis and improves the prognosis of Ewing ’s sarcoma
(Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 6, 2022 Category: Cancer & Oncology Source Type: research

Immune checkpoint inhibitor rechallenge in advanced or metastatic non-small cell lung cancer: a retrospective cohort study
ConclusionICI rechallenge may be an option for NSCLC after progress to immunotherapy. Further studies to confirm the efficacy and investigate prognostic factors are warranted. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 4, 2022 Category: Cancer & Oncology Source Type: research

Dual-specificity phosphatases: therapeutic targets in cancer therapy resistance
ConclusionEmerging evidence indicates that the DUSP family is aberrantly expressed in human malignancies and plays critical roles in determining sensitivity to a wide range of cancer therapeutic strategies through regulation of the MAPK signaling pathways. Consequently, targeting DUSPs and their downstream molecules can pave the way for more effective cancer therapies. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 4, 2022 Category: Cancer & Oncology Source Type: research

Prevalence of abnormal Pap smear results in inflammatory bowel disease: a prospective study
ConclusionThe prevalence of abnormal cervical smears is higher in IBD patients compared to healthy individuals, but the difference is confined to patients with IBD and immunosuppressive therapy. Annual screening is advisable. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 3, 2022 Category: Cancer & Oncology Source Type: research

Animal study of a newly designed metal airway brachytherapy stent loaded with radioactive 125I seeds
AbstractAimTo evaluate dynamic tissue changes after airway stenting (AS) with a newly designed metal brachytherapy stent (BS) loaded with radioactive125I seeds in normal rabbits.MethodsForty-five normal New Zealand white rabbits were divided into 3 groups (group  A: stent without seeds; group B: stent with 0.4 mCi active seeds; group C: stent with 0.8 mCi active seeds) and underwent AS under C-arm guidance. Then, five rabbits were killed from each group at 2, 4, and 8 weeks for further examination. Laboratory tests (including routine blood tests, live r function, kidney function, and electroly...
Source: Journal of Cancer Research and Clinical Oncology - January 3, 2022 Category: Cancer & Oncology Source Type: research

Improvement in colorectal cancer outcomes over time is limited to patients with left-sided disease
ConclusionColorectal cancer outcomes during the last 35  years have preferentially improved in LCRC but not in RCC, indicating that the progress made is limited to LCRC. It is necessary to define RCC as a distinct form of CRC and to focus on specific strategies for its early detection and treatment. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 3, 2022 Category: Cancer & Oncology Source Type: research

Aberrant expression and genetic alteration of c-MYC in anaplastic large cell lymphoma
AbstractPurposec-MYC plays an important role in regulating cellular growth and apoptosis, and it is aberrantly expressed in many human malignancies. Although c-MYC has been extensively investigated in Burkitt lymphoma and diffuse large B cell lymphoma, little has been reported in anaplastic large cell lymphoma (ALCL). The aim of this study was to investigate the expression and genetic alterations of c-MYC in primary systemic ALCL, characterize its clinicopathologic features and immunophenotypes, and discuss their implications in prognosis.MethodsTissue microarrays using samples from 85 ALCL patients were used to evaluate e...
Source: Journal of Cancer Research and Clinical Oncology - January 1, 2022 Category: Cancer & Oncology Source Type: research

Post-operative hypofractionated radiotherapy for prostate cancer: a mono-institutional analysis of toxicity and clinical outcomes
ConclusionsOur experience supports the use of moderate hypofractionation for prostate bed radiotherapy, with minimal toxicity and promising results in terms of clinical outcomes. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 1, 2022 Category: Cancer & Oncology Source Type: research

Living donor liver transplantation for advanced hepatocellular carcinoma including macrovascular invasion
ConclusionWith inclusion of AFP, response to downstaging and degree of MVI, acceptable survival can be achieved with LDLT for HCC outside traditional criteria. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 1, 2022 Category: Cancer & Oncology Source Type: research

Association of recipient and donor interleukin 6 polymorphisms 174 and 597 with outcome after allogeneic hematopoietic stem cell transplantation in children
ConclusionOur study identified the IL6-174 and IL6-597 GG genotypes of pediatric allogeneic HSCT recipients as genetic risk factors for the development of acute GVHD and chronic GVHD. After evaluations in further studies, these findings could implicate the adjustment of prophylactic measures to reduce the occurrence of acute GVHD and chronic GVHD. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 1, 2022 Category: Cancer & Oncology Source Type: research

Survival predictors of 177Lu-Dotatate peptide receptor radionuclide therapy (PRRT) in patients with progressive well-differentiated neuroendocrine tumors (NETS)
This study examines survival predictors in patients who received177Lu-Dotatate.MethodsA retrospective single-center review was conducted, examining 47 individuals with progressive well-differentiated NETs treated with177Lu-Dotatate (four induction cycles of 5.5  GBq at 10-week intervals followed by eight maintenance cycles of 3.7 GBq at 6-month intervals).ResultsMedian follow-up was 63.1  months with a median progression-free survival (PFS) of 34.1 months. However, median overall survival (OS) was not reached at the time of analysis. The presence of ≥ 5 bone metastases (hazard ratio HR 4.33;p&...
Source: Journal of Cancer Research and Clinical Oncology - January 1, 2022 Category: Cancer & Oncology Source Type: research

Correction to: GSTM1 and GSTT1 double null genotypes determining cell fate and proliferation as potential risk factors of relapse in children with hematological malignancies after hematopoietic stem cell transplantation
(Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 1, 2022 Category: Cancer & Oncology Source Type: research

Correction to: Patterns of glioblastoma treatment and survival over a 16-years period: pooled data from the German Cancer Registries
A correction to this paper has been published: https://doi.org/10.1007/s00432-021-03638-y (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 1, 2022 Category: Cancer & Oncology Source Type: research

Correction to: Validity of  using immunohistochemistry to predict treatment outcome in patients with non-small cell lung cancer not otherwise specified
In the original article published. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 1, 2022 Category: Cancer & Oncology Source Type: research

Carboplatin and nab-paclitaxel chemotherapy with or without atezolizumab as front-line management for treatment-na ïve metastatic nonsquamous non-small cell lung cancer with PD-L1 staining: a retrospective study
AbstractPurposeThe aim of this retrospective review was to compare the efficacy and safety of the atezolizumab plus carboplatin and nab-paclitaxel regimen versus the carboplatin and nab-paclitaxel regimen as front-line management for treatment-na ïve, metastatic nonsquamous programmed death-ligand 1 (PD-L1)-positive non-small cell lung cancer (NSCLC) in a selected population.MethodsConsecutive patients with untreated, metastatic nonsquamous PD-L1-positive NSCLC who initially received the atezolizumab plus carboplatin and nab-paclitaxel (ACN) regimen or carboplatin and nab-paclitaxel (CN) regimen were retrospectively i...
Source: Journal of Cancer Research and Clinical Oncology - January 1, 2022 Category: Cancer & Oncology Source Type: research

Correction to: SOX2 inhibits metastasis in gastric cancer
(Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 22, 2021 Category: Cancer & Oncology Source Type: research

Single-cell transcriptomic landscapes of a rare human laryngeal chondrosarcoma
ConclusionThis single-cell sequencing approach provides clues for deciphering the potential mechanisms of tumor heterogeneity and TME composition in laryngeal chondrosarcoma, and represents an important step towards the treatment of laryngeal chondrosarcoma. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 21, 2021 Category: Cancer & Oncology Source Type: research

Solitary colorectal liver metastasis: overview of treatment strategies and role of prognostic factors
AbstractThe following is an overview of the treatment strategies and the prognostic factors to consider in the therapeutic choice of patients characterized by solitary colorectal liver metastasis. Liver resection is the only potential curative option; nevertheless, only 25% of the patients are considered to be eligible for surgery. To expand the potentially resectable pool of patients, surgeons developed multidisciplinary techniques like portal vein embolization, two-stage hepatectomy or associating liver partition and portal vein ligation for staged hepatectomy. Moreover, mini-invasive surgery is gaining support, since it...
Source: Journal of Cancer Research and Clinical Oncology - December 16, 2021 Category: Cancer & Oncology Source Type: research

Low blood levels of high-density lipoprotein (HDL) cholesterol are positively associated with cancer
ConclusionOur data strongly support the hypothesis that serum-specific lipid profiles are positively associated with cancer. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 12, 2021 Category: Cancer & Oncology Source Type: research

Prevalence of diabetes mellitus among 80,193 gastrointestinal cancer patients in five European and three Asian countries
ConclusionOur data revealed a high prevalence of DM among digestive tract cancer patients in Europe and Asia, and showed that DM prevalence varies among digestive tract cancer sites as well as countries. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 12, 2021 Category: Cancer & Oncology Source Type: research

Correction to: Efficacy of single-site radiotherapy plus PD-1 inhibitors vs PD-1 inhibitors for oligometastatic non-small cell lung cancer
(Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 8, 2021 Category: Cancer & Oncology Source Type: research

Quality of life, distress, and posttraumatic growth 5  years after colorectal cancer diagnosis according to history of inpatient rehabilitation
AbstractPurposeIn Germany, almost every other colorectal cancer (CRC) patient undergoes inpatient cancer rehabilitation (ICR), but research on long-term outcomes is sparse. We aimed to assess health-related quality of life (HRQOL), distress, and posttraumatic growth among former rehabilitants and non-rehabilitants as well as respective differences and to estimate disease-related quality of life deficits in both groups.MethodsHRQOL (EORTC-QLQ-C30/CR29), distress (QSC-R10), and posttraumatic growth (PTGI) were assessed according to past ICR in patients 5-year post-CRC-diagnosis in the German DACHS study. Least square mean di...
Source: Journal of Cancer Research and Clinical Oncology - December 7, 2021 Category: Cancer & Oncology Source Type: research

Presence of autoantibodies in serum does not impact the occurrence of immune checkpoint inhibitor-induced hepatitis in a prospective cohort of cancer patients
ConclusionWe found nominally significant associations of ICI-induced hepatitis with two HLA alleles. ICI-induced hepatitis showed no correlation with liver-specific autoantibodies, but frequently co-occurred with irAEs affecting other organs. Unlike other irAEs, ICI-induced hepatitis is not associated with a better prognosis. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 7, 2021 Category: Cancer & Oncology Source Type: research

Targeting abundant survivin expression in liposarcoma: subtype dependent therapy responses to YM155 treatment
ConclusionThese findings support the significant role of survivin in the oncogenesis and progression of LPS subtypes providing a rationale to target survivin in eligible in-vivo models and to pioneer clinical applications of survivin-specific substances unfolding their therapeutic potential in LPS patients prospectively. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 3, 2021 Category: Cancer & Oncology Source Type: research

Correction to: The eagle sign: a new preoperative MRI-based tool for predicting topographic correlation between craniopharyngioma and hypothalamus
(Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 2, 2021 Category: Cancer & Oncology Source Type: research

The impact of modern radiotherapy on long-term cardiac sequelae in breast cancer survivor: a focus on deep inspiration breath-hold (DIBH) technique
ConclusionsBC patients often have a long life expectancy, thus the RT should aim at limiting toxicities and at the same time maintaining the same high cure rates. Further studies are needed to evaluate the risk –benefit ratio to identify patients at higher risk and to tailor the treatment choices. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 1, 2021 Category: Cancer & Oncology Source Type: research

Selective induction of rapid cytotoxic effect in glioblastoma cells by oscillating magnetic fields
ConclusionRotating magnetic fields produced by a new noninvasive device selectively kill cultured human glioblastoma and non-small cell lung cancer cells by raising intracellular reactive oxygen species, but not normal human tissue cells. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - October 31, 2021 Category: Cancer & Oncology Source Type: research

Validation of ZMYND8 as a new treatment target in hepatocellular carcinoma
ConclusionZMYND8 mRNA overexpression could be a prognostic marker of shorter RFS in HCC patients after curative resection. ZMYND8 might play an important role in the proliferation and progression of HCC and could be a promising candidate for targeted therapy. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - October 31, 2021 Category: Cancer & Oncology Source Type: research

Using deep learning to predict microvascular invasion in hepatocellular carcinoma based on dynamic contrast-enhanced MRI combined with clinical parameters
ConclusionThe proposed DLC model can provide a non-invasive approach to evaluate MVI before surgery, which can help surgeons make decisions of surgical strategies and assess patient ’s prognosis. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - October 31, 2021 Category: Cancer & Oncology Source Type: research

Peritumoral edema status of glioblastoma identifies patients reaching long-term disease control with specific progression patterns after tumor resection and high-dose proton boost
AbstractBackgroundGlioblastoma peritumoral edema (PE) extent is associated with survival and progression pattern after tumor resection and radiotherapy (RT). To increase tumor control, proton beam was adopted to give high-dose boost (>  90 Gy). However, the correlation between PE extent and prognosis of glioblastoma after postoperative high-dose proton boost (HDPB) therapy stays unknown. We intend to utilize the PE status to classify the survival and progression patterns.MethodsPatients receiving HDPB (96.6 GyE) were retrospectively evaluated. Limited peritumoral edema (LPE) was defined as PE extent  
Source: Journal of Cancer Research and Clinical Oncology - October 31, 2021 Category: Cancer & Oncology Source Type: research

The effect of adjuvant therapies on long-term outcome for primary resected synovial sarcoma in a series of mainly children and adolescents
DiscussionOmission of chemotherapy in a non-stratified way seems not justified. Size governs survival due to high linear association with risk of suffering metastatic recurrence in a granular classification. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - October 31, 2021 Category: Cancer & Oncology Source Type: research

Economics influences therapy decisions in chronic myeloid leukaemia: should it?
AbstractThe question whether economic considerations should influence therapy decisions in persons with chronic myeloid leukaemia (CML) is complex touching on many metrics other than medicine including the perceptions, attitudes, and motivations of physicians, patients, their families, and payors ’, allocation of health care resources, and others. We discuss metrics whereby physicians, patients, and payors make CML therapy choices in settings where cost and availability are or are not considerations. We conclude that economic considerations strongly influence therapy decisions in CML. Whet her this should be so and w...
Source: Journal of Cancer Research and Clinical Oncology - October 31, 2021 Category: Cancer & Oncology Source Type: research

Regorafenib versus cabozantinb as second-line treatment after sorafenib for unresectable hepatocellular carcinoma: matching-adjusted indirect comparison analysis
We report here a MAIC of second-line MKI options for patients with HCC previously treated with sorafenib using individual real-world data of regorafenib and aggregate data of second-line cabozantinib from the CELESTIAL trial.MethodsData from 278 patients who received regorafenib as second-line therapy after sorafenib failure for unresectable HCC were used as IPD. Data inclusion were adapted to those reported in the CELESTIAL trial in the subset of patients who received sorafenib as the only prior therapy. Survival medians and rates were obtained from Kaplan –Meier curves, and differences between regorafenib and caboz...
Source: Journal of Cancer Research and Clinical Oncology - October 31, 2021 Category: Cancer & Oncology Source Type: research

Ground glass opacity featured lung adenocarcinoma in teenagers
ConclusionsGGO nodules could be a sign of early-stage teenage lung adenocarcinoma. We proposed a screening strategy with long intervals based on a baseline CT scan for the teenage population, and a treatment strategy for diagnosed teenage patients. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - October 31, 2021 Category: Cancer & Oncology Source Type: research