Characterization of carfilzomib-resistant non-small cell lung cancer cell lines
ConclusionsUpregulation of Pgp appears to be an important, but not the only, mechanism of CFZ resistance in NSCLC cell lines. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - June 14, 2018 Category: Cancer & Oncology Source Type: research

Role of the NRP-1-mediated VEGFR2-independent pathway on radiation sensitivity of non-small cell lung cancer cells
AbstractPurposeTo determine if inhibiting neuropilin-1 (NRP-1) affects the radiosensitivity of NSCLC cells through a vascular endothelial growth factor receptor 2 (VEGFR2)-independent pathway, and to assess the underlying mechanisms.MethodsThe expression of VEGFR2, NRP-1, related signaling molecules, abelson murine leukemia viral oncogene homolog 1 (ABL-1), and RAD51 were determined by RT-PCR and Western blotting, respectively. Radiosensitivity was assessed using the colony-forming assay, and the cell apoptosis were analyzed by flow cytometry.ResultsWe selected two cell lines with high expression levels of VEGFR2, includin...
Source: Journal of Cancer Research and Clinical Oncology - June 14, 2018 Category: Cancer & Oncology Source Type: research

The prognostic role of HBV infection in chronic lymphocytic leukemia
AbstractPurposeWe attempt to assess the impact of hepatis-B virus (HBV) status on the prognosis of chronic lymphocytic leukemia (CLL) using a Chinese case cohort.MethodsFive hundred and one consecutive newly diagnosed subjects with CLL were enrolled in this case cohort. HBV infection was defined as hepatitis B surface antigen (HBsAg) positive or hepatitis-B core antibody (HBcAb) positive. Univariate and stepwise multivariate Cox regression analyses were used to screen the prognostic risk factors associated with the end point of time-to-treatment (TTT) or overall survival (OS). Bootstrap re-sampling method was used to evalu...
Source: Journal of Cancer Research and Clinical Oncology - June 14, 2018 Category: Cancer & Oncology Source Type: research

Tumoral cavitation in colorectal cancer patients with unresectable lung metastasis treated with bevacizumab and chemotherapy
ConclusionBevacizumab in combination with chemotherapy exhibited promising efficacy in mCRC patients LMs. Moreover, our findings reveal that OS might be affected by new tumor cavitation during antiangiogenic agent treatment. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - June 14, 2018 Category: Cancer & Oncology Source Type: research

Response to “Commentary on: Lung cancer screening with MRI: results of the first screening round”: Ngam Pei Ing et al.
(Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - June 14, 2018 Category: Cancer & Oncology Source Type: research

Association between pathologic factors and ERG expression in prostate cancer: finding pivotal networking
ConclusionsEvaluating the association between ERG expression and pathologic factors, and identifying the regulatory network and pivotal hub may help to understand the clinical significance of ERG-positive prostate cancer. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - June 12, 2018 Category: Cancer & Oncology Source Type: research

Cancer-associated fibroblasts promote gastric tumorigenesis through EphA2 activation in a ligand-independent manner
ConclusionCAFs may contribute to gastric tumorigenesis by activating EphA2 signaling pathway in a ligand-independent manner. Our results suggest that ligand-independent activation of EphA2 was triggered by VEGF released from CAF-CM. Our result may partially explain why ligand-dependent tumor suppressor roles of EphA2 are not evident in gastric cancer despite the prominent level of ephrinA1. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - June 12, 2018 Category: Cancer & Oncology Source Type: research

Molecular classification and subtype-specific characterization of skin cutaneous melanoma by aggregating multiple genomic platform data
ConclusionsSkin cutaneous melanoma can be robustly divided into three subtypes by SNFCC+. Compared with the TCGA classification derived from gene expression, the subtypes we presented share concordance, but new traits are excavated. Such a genomic classification offers insights to further personalize therapeutic decision-making and melanoma management. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - June 11, 2018 Category: Cancer & Oncology Source Type: research

Trastuzumab-induced cardiotoxicity and its risk factors in real-world setting of breast cancer patients
AbstractPurposeCardiotoxicity is the most important side effect of trastuzumab treatment. Heart function monitoring is recommended during the treatment which has led to growing use of resources. The aim of this retrospective study was to determine the frequency and timing of trastuzumab cardiotoxicity and its risk factors in real-world setting.MethodsSingle institute, retrospective collection of data onHER2+ breast cancer patients (n = 246) was carried out through a pharmacy search for patients who had received trastuzumab in 2006–2014. Clinical and pathological factors, treatment history, EF measuremen...
Source: Journal of Cancer Research and Clinical Oncology - June 5, 2018 Category: Cancer & Oncology Source Type: research

Downregulation of Raf-1 kinase inhibitory protein as a sorafenib resistance mechanism in hepatocellular carcinoma cell lines
ConclusionReactivation of the Raf/MEK/ERK pathway through aberrant expression of RKIP is one of the mechanisms behind sorafenib resistance in HCC. Sequential combination treatment with sorafenib and PD98059 could provide a new strategy to overcome sorafenib resistance in future clinical studies. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - June 1, 2018 Category: Cancer & Oncology Source Type: research

Effects of sequentially applied single and combined temozolomide, hydroxychloroquine and AT101 treatment in a long-term stimulation glioblastoma in vitro model
ConclusionsSequential treatment with mechanistically different acting drugs might be an option to reduce side effects in long-term treatment, for example in local administration approaches. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - June 1, 2018 Category: Cancer & Oncology Source Type: research

Survival analysis and pathological features of advanced non-small cell lung cancer with miliary pulmonary metastases in patients harboring epidermal growth factor receptor mutations
ConclusionThe prognosis of patients with  advanced NSCLC harboring EGFR mutations with miliary pulmonary metastasis demonstrated significantly worse outcomes compared to those without miliary pulmonary metastasis. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - June 1, 2018 Category: Cancer & Oncology Source Type: research

Hyaluronic acid-modified polyamidoamine dendrimer G5-entrapped gold nanoparticles delivering METase gene inhibits gastric tumor growth via targeting CD44+ gastric cancer cells
ConclusionHA-G5 PAMAM-Au-METase significantly suppressed tumor growth of GC by targeted damaging the mitochondrial function of CD44(+) gastric CSCs. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - June 1, 2018 Category: Cancer & Oncology Source Type: research

Cartilage oligomeric matrix protein is a prognostic factor and biomarker of colon cancer and promotes cell proliferation by activating the Akt pathway
ConclusionsCOMP may be a novel prognostic indicator and biomarker and also a potential therapeutic target for colon cancer. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - May 12, 2018 Category: Cancer & Oncology Source Type: research

Impact of peri-operative blood transfusion on post-operative infections after radical gastrectomy for gastric cancer: a propensity score matching analysis focusing on the timing, amount of transfusion and role of leukocyte depletion
ConclusionInfection was the most common complication following gastrectomy for gastric cancer and BTF was identified as an independent risk factor by propensity score matching and multivariate analyses. The timing, amount of transfusion and leukocyte depletion had an impact on the incidence of infection. To decrease infection, BTF should be avoided where possible, particularly during operation, with a large amount and leukocyte-not-depleted blood. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - May 12, 2018 Category: Cancer & Oncology Source Type: research

Advanced high-grade serous ovarian cancer: inverse association of KLK13 and KLK14 mRNA levels in tumor tissue and patients ’ prognosis
ConclusionThese results indicate that in advanced high-grade serous ovarian cancer KLK13 may become proficient for tumor-supporting functions, whereas KLK14 may have adopted tumor-suppressing activity. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - May 12, 2018 Category: Cancer & Oncology Source Type: research

High MLL2 expression predicts poor prognosis and promotes tumor progression by inducing EMT in esophageal squamous cell carcinoma
ConclusionOur results indicate that overexpression of MLL2 predicts poor clinical outcomes and facilitates ESCC tumor progression, and it may exert oncogenic role via activation of EMT. MLL2 may be used as a novel prognostic factor and therapeutic target for ESCC patients. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - May 12, 2018 Category: Cancer & Oncology Source Type: research

Isocitrate dehydrogenase 2 mutations correlate with leukemic transformation and are predicted by 2-hydroxyglutarate in myelodysplastic syndromes
ConclusionsThe noted predictive value of serum 2-HG levels andIDH2 mutations on OS and LFS support the use of biomarkers and/or underlying cytogenetics in novel prognostic scoring systems for MDS. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - May 12, 2018 Category: Cancer & Oncology Source Type: research

Therapeutic potential of GSK-J4, a histone demethylase KDM6B/JMJD3 inhibitor, for acute myeloid leukemia
ConclusionsIn summary, our findings suggest that targeting KDM6B with GSK-J4 has a therapeutic potential for the treatment of AML. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - May 12, 2018 Category: Cancer & Oncology Source Type: research

Mapping of lateral pelvic lymph node recurrences in rectal cancer: a radiation oncologist ’s perspective
ConclusionThe LPLN component of pre- or postoperative irradiation volumes could potentially be optimized based on our mapping data. However, since patients in our institution at high risk for relapse received either preoperative or postoperative chemoradiation, further analyses are needed to confirm our findings. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - May 12, 2018 Category: Cancer & Oncology Source Type: research

Sunitinib shrinks NET-G3 pancreatic neuroendocrine neoplasms
ConclusionOur results indicate that sunitinib is as effective for NET-G3 as for NET-G1/2. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - May 12, 2018 Category: Cancer & Oncology Source Type: research

CD274, LAG3, and IDO1 expressions in tumor-infiltrating immune cells as prognostic biomarker for patients with MSI-high colon cancer
ConclusionCD274, LAG3, and IDO1 expressions in TIICs showed a better prognosis for patients with MSI-H colon cancer. Thus, the potential therapeutic implications of these immune checkpoint molecules should be further investigated. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - May 12, 2018 Category: Cancer & Oncology Source Type: research

Combinational chromosomal aneuploidies and HPV status for prediction of head and neck squamous cell carcinoma prognosis in biopsies and cytological preparations
ConclusionThe combination of HPV status and prognostic copy number alteration detected by FISH in biopsies or cytological specimens may be an applicable protocol for screening head and neck cancer patients prior to therapy. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - May 12, 2018 Category: Cancer & Oncology Source Type: research

Ovarian metastasis in patients with endometrial cancer: risk factors and impact on survival
AbstractBackgroundOophorectomy is generally performed in patients with endometrial cancer despite the rate of ovarian metastasis being relatively low.Patients and methodsA multicenter retrospective registry-based study was performed in 2329 patients with endometrial cancer. The outcome measures were the incidence of ovarian metastasis and the impact on overall survival.ResultsMedian follow-up was performed at 84  months. A total of 2158 women were eligible for analysis, of which 131 (6.1%) had ovarian metastasis. Women with ovarian metastasis were more likely to have>  50% myometrial invasion, undifferentiat...
Source: Journal of Cancer Research and Clinical Oncology - May 12, 2018 Category: Cancer & Oncology Source Type: research

Predictors of recurrence and survival of pathological T1N0M0 invasive adenocarcinoma following lobectomy
AbstractBackgroundThis retrospective research was designed to investigate the relationship between pT1N0M0 invasive adenocarcinoma (IADC) harboring solid (SOL) and/or micropapillary (MIP) components and its prognosis following lobectomy.MethodsClinical data of pT1N0M0 IADC patients were retrospectively collected from Shanghai Chest Hospital. Survival curves were plotted by Kaplan –Meier methods. Multivariable cox regressions were conducted to discover the independent risk factors of recurrence-free survival (RFS) and overall survival (OS), through which nomograms were performed to visualize the risk of recurrences an...
Source: Journal of Cancer Research and Clinical Oncology - May 12, 2018 Category: Cancer & Oncology Source Type: research

“Commentary on: Lung cancer screening with MRI: results of the first screening round”—Michael Meier-Schroers et al.
(Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - May 10, 2018 Category: Cancer & Oncology Source Type: research

Co-expression of NGF and PD-L1 on tumor-associated immune cells in the microenvironment of Merkel cell carcinoma
ConclusionsThe present study shows that PD-L1 and NGF are co-expressed on spindle cells in the microenvironment. The expression of NGF might be a link of the microenvironment to the TrkA-positive tumor cells. Whether this mechanism is critical for tumor growth and lack of response to anti-PD-1/L1 treatment has to be investigated in further studies. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - May 9, 2018 Category: Cancer & Oncology Source Type: research

Mycoplasma hyorhinis reduces sensitivity of human lung carcinoma cells to Nutlin-3 and promotes their malignant phenotype
We examined the influence ofMycoplasma hyorhinis infection on sensitivity of human lung carcinoma cells NCI-H292 to MDM2 inhibitor Nutlin-3. In order to unveil possible mechanisms underlying the revealed effect, we investigated gene expression changes and signal transduction networks activated in NCI-H292 cells in response to mycoplasma infection.MethodsSensitivity of NCI- Н292 cells to Nutlin-3 was estimated by resazurin-based cell viability assay. Genome-wide transcriptional profiles of NCI-H292 and NCI-Н292Myc.h cell lines were determined using Illumina Human HT-12 v3 Expression BeadChip. Search for key transcription ...
Source: Journal of Cancer Research and Clinical Oncology - May 8, 2018 Category: Cancer & Oncology Source Type: research

hIL-15-gene modified human natural killer cells (NKL-IL15) exhibit anti-human leukemia functions
ConclusionsThese results provided evidence that IL-15 gene-modification could augment NK cell-mediated anti-human leukemia function, which would improve primary NK cell-based immunotherapy for leukemia in future. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - May 8, 2018 Category: Cancer & Oncology Source Type: research

Analysis of clinical characteristics and prognosis factors of 71 cases with HIV-negative Castleman ’s disease: hypoproteinemia is an unfavorable prognostic factor which should be treated appropriately
ConclusionsOur study emphasized the distinction of clinical characteristics between UCD and MCD and the importance of different poor risk factors of different clinical classifications which may directed more precise and appropriate treatment strategy. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - May 7, 2018 Category: Cancer & Oncology Source Type: research

Vaginal brachytherapy for endometrial cancer
AbstractBackgroundThere is limited information about survival effect of vaginal brachytherapy (VBT) and its comparison to external beam pelvic radiotherapy (EBRT) and no radiotherapy (no-RT) of endometrial cancer patients.Patients and methodsWe performed a multicenter retrospective registry study of 1550 patients with endometrial cancer treated by no-RT (n = 702), VBT (n = 430) and EBRT ± VBT (n = 418). The outcome measure was overall survival.ResultsRT did not improve the overall survival of patients with a low risk of recurrence. In univariate analysis, the s...
Source: Journal of Cancer Research and Clinical Oncology - May 5, 2018 Category: Cancer & Oncology Source Type: research

Identification of aberrantly expressed F-box proteins in squamous-cell lung carcinoma
ConclusionsOur results provide evidence that FBXO45 and FBXO5 may play a key role in tumorigenesis and prognosis of SqCLC. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - May 4, 2018 Category: Cancer & Oncology Source Type: research

Tumor cell expression of CD163 is associated to postoperative radiotherapy and poor prognosis in patients with breast cancer treated with breast-conserving surgery
ConclusionsOur results suggest that macrophage phenotype in tumor cells results in radioresistance in breast cancer and shorter DFS after radiotherapy. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - May 3, 2018 Category: Cancer & Oncology Source Type: research

Status and future directions in the management of pancreatic cancer: potential impact of nanotechnology
AbstractPancreatic ductal adenocarcinoma (PDAC) is typically diagnosed at a late stage, has limited treatments, and patients have poor survival rates. It currently ranks as the seventh leading cause of cancer deaths globally and has increasing rates of diagnosis. Improved PDAC treatment requires the development of innovative, effective, and economical therapeutic drugs. The late stage diagnosis limits options for surgical resection, and traditional PDAC chemotherapeutics correlate with increased organ and hematologic toxicity. In addition, PDAC tumor tissue is dense and highly resistant to many traditional chemotherapeutic...
Source: Journal of Cancer Research and Clinical Oncology - May 2, 2018 Category: Cancer & Oncology Source Type: research

The influence of mutational status and biological characteristics of acute myeloid leukemia on xenotransplantation outcomes in NOD SCID gamma mice
ConclusionsThe engraftment of AML was influenced by mutation-interactions and other AML characteristics, rather than by single mutated genes, and engraftment intensity best reflected clinical penetrance of AML. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - May 2, 2018 Category: Cancer & Oncology Source Type: research

Author Correction: Mitochondrial DNA variants in colorectal carcinogenesis: Drivers or passengers?
The affiliation detail for the corresponding author, Edoardo Errichiello, was published incorrectly. The correct detail read as follows: (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - May 2, 2018 Category: Cancer & Oncology Source Type: research

Somatic BRCA1 mutations in clinically sporadic breast cancer with medullary histological features
ConclusionsBRCA1 mutation testing may be useful in clinically sporadic breast cancer patients with medullary features to identify potential mutation carriers independently from intrinsic molecular subtype. Formalin-fixed paraffin-embedded cancer tissue can undergo testing within a routine molecular-diagnostic setting as a clinicalBRCA1/2 mutation screening strategy. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 25, 2018 Category: Cancer & Oncology Source Type: research

Competing nomograms help in the selection of elderly patients with colon cancer for adjuvant chemotherapy
AbstractPurposeThe extent to which  ≥ 70 year patients with colon cancer benefit from adjuvant chemotherapy in the presence of competing risks remains controversial.Methods18,937 patients  ≥ 70 years with high-risk stage II and stage III colon cancer were retrospectively reviewed from SEER database. Propensity score matching (PSM) was used to adjust for potential baseline confounding. The nomograms were developed based on the competing model to describe the individual probabil ity of colon cancer-specific death (CCSD) and non-CCSD. The subpopulation treatment-effect pattern plot ...
Source: Journal of Cancer Research and Clinical Oncology - April 25, 2018 Category: Cancer & Oncology Source Type: research

Impact of baseline characteristics on outcomes of advanced HCC patients treated with sorafenib: a secondary analysis of a phase III study
AbstractBackgroundThe current study aims to investigate the impact of baseline characteristics on the outcomes of sorafenib-treated advanced Hepatocellular carcinoma (HCC) patients in the setting of a clinical trial.MethodsThis is a secondary analysis of the comparator arm (sorafenib arm) of the NCT00699374 study which is a phase III multicenter study conducted between 2008 and 2010. The univariate probability of overall and progression-free survival was assessed among different patient subsets through Kaplan –Meier analysis and log-rank testing. Multivariate analysis of factors affecting overall and progression-free...
Source: Journal of Cancer Research and Clinical Oncology - April 25, 2018 Category: Cancer & Oncology Source Type: research

Treatment and outcome of patients with localized intrathoracic and chest wall rhabdomyosarcoma: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS)
ConclusionThoracic RMS is a rare tumor entity. Completeness of tumor resection significantly improved survival of the patients. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 25, 2018 Category: Cancer & Oncology Source Type: research

NIPA-like domain containing 1 is a novel tumor-promoting factor in oral squamous cell carcinoma
In this study, we examined NIPAL1 expression in 192 cases of OSCC by immunohistochemistry and performed a functional analysis of human OSCC cells.ResultsNIPAL1 immunostaining was observed in 39 of 192 OSCC patients (20.3%). NIPAL1 expression correlated significantly with cancer cell intravsation (P = 0.0062), as well as with poorer disease-free survival in a Kaplan–Meier analysis (P 
Source: Journal of Cancer Research and Clinical Oncology - April 25, 2018 Category: Cancer & Oncology Source Type: research

Young adults diagnosed with Hodgkin lymphoma are at risk of relapsing late: a comprehensive analysis of late relapse in Hodgkin lymphoma
AbstractPurposeMajority of relapses in Hodgkin lymphoma (HL) occur within 3  years after initial treatment, late relapses (LR), happening 5 or more years after first diagnosis is rare events. Neither clinical characteristics, risk factors, nor optimal treatment is well described for LR patients. Our aim was to provide a comprehensive analysis on the LR of HL to outline a p atient population at risk of relapsing late.Patients and methods637 HL patients were treated at the University of Debrecen between 1981 and 2010. Patient data was evaluated retrospectively. Survival analysis was performed using the Kaplan –Mei...
Source: Journal of Cancer Research and Clinical Oncology - April 25, 2018 Category: Cancer & Oncology Source Type: research

Durable treatment-free remission in patients with chronic myeloid leukemia in chronic phase following frontline nilotinib: 96-week update of the ENESTfreedom study
ConclusionsThese results demonstrate the feasibility and durability of TFR following frontline nilotinib and emphasize the importance of sustained DMR for TFR. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 25, 2018 Category: Cancer & Oncology Source Type: research

Ablative dual-phase Erbium:YAG laser treatment of atrophy-related vaginal symptoms in post-menopausal breast cancer survivors omitting hormonal treatment
ConclusionsBreast cancer survivors with atrophy-related complaints after pelvic floor surgery may benefit from vaginal application of this innovative dual protocol of Er:YAG laser technology as a non-hormonal treatment approach. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 25, 2018 Category: Cancer & Oncology Source Type: research

Retrospective validation of the laparoscopic ICG SLN mapping in patients with grade 3 endometrial cancer
ConclusionsLaparoscopic NIR-ICG SLN mapping in high-risk endometrial cancer patients has acceptable sensitivity, FN rate, and NPV. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 24, 2018 Category: Cancer & Oncology Source Type: research

Erlotinib in routine clinical practice for first-line maintenance therapy in patients with advanced non-small cell lung cancer (NSCLC)
ConclusionsThe results of this non-interventional study support the current clinical practice of erlotinib switch maintenance in EGFR-mutation-positive patients. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 23, 2018 Category: Cancer & Oncology Source Type: research

Chemotherapy treatment is associated with altered PD-L1 expression in lung cancer patients
ConclusionsThis is the first study, in which both PD-L1 and PD-1 expression were analyzed together with the amount of stromal IC infiltration in different histological subtypes of lung cancer before and after platinum-based chemotherapy. Our results confirm that chemotherapy decreases PD-L1 expression of TC in a subset of patients, therefore, rebiopsy and re-evaluation of PD-L1 expression may be necessary for the indication of immune checkpoint inhibitor therapy. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 19, 2018 Category: Cancer & Oncology Source Type: research

Maintenance in myeloma patients achieving complete response after upfront therapy: a pooled analysis
AbstractPurposeMaintenance demonstrated to improve survival in newly diagnosed multiple myeloma (NDMM) patients and the achievement of complete response (CR) is a strong predictor of survival. Nevertheless, the role of maintenance according to response after induction/consolidation has not been investigated so far. To evaluate the impact of maintenance according to response, we pooled together and retrospectively analyzed data from 955 NDMM patients enrolled in two trials (GIMEMA-MM-03-05 and RV-MM-PI-209).MethodsPrimary endpoints were progression-free survival (PFS)1, PFS2 and overall survival (OS) of CR patients randomiz...
Source: Journal of Cancer Research and Clinical Oncology - April 19, 2018 Category: Cancer & Oncology Source Type: research

No influence of smoking status on the performance of urine markers for the detection of bladder cancer
ConclusionsOur results strongly suggest that smoking habits do not affect performance characteristics of urinary markers in the diagnostics of BC. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 19, 2018 Category: Cancer & Oncology Source Type: research

Patterns of breast cancer relapse in accordance to biological subtype
ConclusionBreast cancer subtypes are associated with different time and pattern of recurrence and it should be considered during treatment decision. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 19, 2018 Category: Cancer & Oncology Source Type: research