Socioeconomic disparities in head and neck cancer survival in Germany: a causal mediation analysis using population-based cancer registry data
ConclusionThis study confirms the survival disparity between affluent and deprived HNC patients in Germany. Considering data limitations, our results suggest that, within six months after HNC diagnosis, the elimination of differences in stage at diagnosis could reduce survival inequalities. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 6, 2021 Category: Cancer & Oncology Source Type: research

Metastasis-directed stereotactic body radiation therapy in the management of oligometastatic head and neck cancer
ConclusionsSBRT can be considered a safe metastasis-directed therapy in oligometastatic HNC.Efficacy of the treatment seems to be higher when administered upfront in the management of metastatic disease; however, selection of patients need to be improved due to the relevant risk of appearance of new metastatic site after SBRT. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 6, 2021 Category: Cancer & Oncology Source Type: research

Clinicopathological impacts of DNA methylation alterations on pancreatic ductal adenocarcinoma: prediction of early recurrence based on genome-wide DNA methylation profiling
ConclusionThese findings indicate that DNA methylation alterations may have a clinicopathological impact on PDAC. Application of our criteria will ultimately allow prediction of ER after surgery to improve the outcome of PDAC patients. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 6, 2021 Category: Cancer & Oncology Source Type: research

Bi-direction effects between microbiome and MiRNAs in carcinogenesis
AbstractThere is evidence from numerous studies that dysbiosis of the microbiome provokes various immune-mediated diseases, obesity, diabetes, and cancers by regulating metabolites, host genetics, environmental elements, and stress. Such reports are yet to define an accurate regulatory network for host-gut microbiome communication. miRNAs have recently emerged as crucial mediators of this communication, as portrayed by their interaction with the host microbiome. This mini-review summarizes the bi-direction effects between miRNA and microbiome and elucidates their role in carcinogenesis. An in-depth understanding of the ass...
Source: Journal of Cancer Research and Clinical Oncology - April 6, 2021 Category: Cancer & Oncology Source Type: research

Clinical application of circulating tumor DNA in breast cancer
AbstractBackgroundThe recent advancement in massively parallel sequencing technologies has empowered liquid biopsies, in particular circulating tumor DNA (ctDNA) analysis, to be the new paradigm in personalized cancer management. Plasma ctDNA detection overcomes the current limitations in tumor tissue procurement and serves as a convenient and non-invasive method to capture tumor heterogeneity and genetic evolution along patients' cancer journey.Summary of findingsIn breast cancer, the current clinical application of ctDNA includes real-time monitoring of tumor response, detection of drug-resistant clones, assessing dynami...
Source: Journal of Cancer Research and Clinical Oncology - April 6, 2021 Category: Cancer & Oncology Source Type: research

Diet-related interventions for cancer-associated cachexia
ConclusionOngoing studies will continue to examine whether different forms of multimodal therapy —combinations of cancer treatment, dietary regimens, anti-inflammatory therapy, and physical therapy—are effective methods to improve outcomes in advanced cancer patients with cachexia. Moreover, future studies should examine the effects of such interventions on long-term QoL and establish nutri tional guidelines for the management of cancer-associated cachexia. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 6, 2021 Category: Cancer & Oncology Source Type: research

The tumor suppressor role of salvador family WW domain-containing protein 1 (SAV1): one of the key pieces of the tumor puzzle
ConclusionSAV1 plays a relevant role as tumor suppressor in several types of cancer, highlighting SAV1 and the Hippo pathway's importance to cancer. Thus, encouraging further studies to include the SAV1 as a molecular key piece in cancer biology and in clinical approaches to cancer. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 6, 2021 Category: Cancer & Oncology Source Type: research

Correction to: Association of PD-L1 and IDO1 expression with JAK –STAT pathway activation in soft-tissue leiomyosarcoma
In the original article published, the data of AJCC stage. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 6, 2021 Category: Cancer & Oncology Source Type: research

Clinical characteristics and comparison of the outcome in young versus older patients with upper gastrointestinal carcinoma
(Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 6, 2021 Category: Cancer & Oncology Source Type: research

Comment on article by Christina Puhr Hannah et al.: Clinical characteristics and comparison of the outcome in young versus older patients with upper gastrointestinal carcinoma
(Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 6, 2021 Category: Cancer & Oncology Source Type: research

The association between the expression of PD-L1 and CMTM6 in undifferentiated pleomorphic sarcoma
ConclusionsUPS showed variation inCMTM6 copy number and CMTM6 expression. CMTM6 expression was significantly correlated with PD-L1 expression, especially with strong PD-L1 expression. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 3, 2021 Category: Cancer & Oncology Source Type: research

A novel NECTIN4-NTRK1 fusion identified in a lung squamous cell carcinoma patient with MSI-H
(Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 3, 2021 Category: Cancer & Oncology Source Type: research

Network pharmacology-based and clinically relevant prediction of active ingredients and potential targets of Chinese herbs on stage IV lung adenocarcinoma patients
This study is designed to ascertain the relative molecular targets of effective Chinese herbs in treating stage IV lung adenocarcinoma based on clinical data and network pharmacology. In addition, we showed that Chinese Herbal Medicine (CHM) treatment was associated with survival benefit for patients with stage IV lung adenocarcinoma and identified 18 herbs beneficial to survival through correlation analysis.BackgroundIncreasing evidence has shown that CHM has efficient therapeutic effects for advanced lung adenocarcinoma, while active ingredients and potential targets remain unclear.MethodsKaplan –Meier method and C...
Source: Journal of Cancer Research and Clinical Oncology - April 2, 2021 Category: Cancer & Oncology Source Type: research

Prognostic impact of extranodal extension in patients with pN1 –N2 lung adenocarcinoma
ConclusionsIn patients who underwent surgical resection for lung adenocarcinoma with lymph node involvement, the extranodal extension was the most important prognostic factor among morphological lymph node involvement patterns. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 2, 2021 Category: Cancer & Oncology Source Type: research

Traits of cancer patients and CAM usage
ConclusionThis study is among the first to take a more detailed look at how numerous personal traits are associated with the use of CAM methods and differentiate between the applied methods. Our finding should be considered by conventional health care providers and could be integrated into a holistic assessment, to offer information about complementary medicine and meeting patients ’ needs. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 2, 2021 Category: Cancer & Oncology Source Type: research

Tau oligomers accumulation sensitizes prostate cancer cells to docetaxel treatment
ConclusionsOur data indicate that autophagy could exert a promoting role in cancer growth and during chemotherapy facilitating degradation of tau protein and thus blocking the antimitotic effect of accumulated tau oligomers. Thus, therapeutic strategies aimed at stimulating tau oligomers formation, such as autophagy inhibition, could be an effective adjuvant in cancer therapy. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 2, 2021 Category: Cancer & Oncology Source Type: research

The peptide mimicking small extracellular ring domain of CD82 inhibits tumor cell migration in vitro and metastasis in vivo
ConclusionThis novel finding will improve our understanding of the mechanism by which CD82 inhibits metastasis, and suggests that EC1 mimic peptide may be a promising candidate for developing anti-metastasis drugs. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 2, 2021 Category: Cancer & Oncology Source Type: research

NLRC5 regulates expression of MHC-I and provides a target for anti-tumor immunity in transmissible cancers
ConclusionMHC-I could be identified as a target for anti-tumor and allogeneic immunity. Consequently, NLRC5 could be a promising target for immunotherapy and vaccines to protect devils from transmissible cancers and inform development of transplant and cancer therapies for humans. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 2, 2021 Category: Cancer & Oncology Source Type: research

Comprehensive analysis of the clinicopathological features, targetable profile, and prognosis of mucinous adenocarcinoma of the lung
AbstractPurposeThe clinicopathological or genetic features related to the prognosis of mucinous adenocarcinoma are unknown because of its rarity. The clinicopathological or targetable features were investigated for better management of patients with mucinous adenocarcinoma of the lung.MethodsWe comprehensively evaluated the clinicopathological and genetic features of 60 completely resected mucinous lung adenocarcinomas. Targetable genetic variants were explored using nCounter and polymerase chain reaction, PD-L1 and TTF-1 expression were evaluated using immunohistochemistry. We analyzed the prognostic impact using the Kapl...
Source: Journal of Cancer Research and Clinical Oncology - April 1, 2021 Category: Cancer & Oncology Source Type: research

An online tool for predicting the prognosis of cancer patients with SARS-CoV-2 infection: a multi-center study
ConclusionOverall, cancer patients with SARS-CoV-2 had unique clinical features, and the established online tool could guide clinicians to predict the prognosis of patients during the COVID-19 epidemic and to develop more rational treatment strategies for cancer patients. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 12, 2021 Category: Cancer & Oncology Source Type: research

Resveratrol induces PD-L1 expression through snail-driven activation of Wnt pathway in lung cancer cells
ConclusionWe conclude that resveratrol is capable to suppress anti-tumor immunity by controlling mainly PD-L1 expression. This finding will extend the understanding of resveratrol in regulation of tumor immunity and is relevant to the debate on resveratrol supplements for lung cancer patients. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 12, 2021 Category: Cancer & Oncology Source Type: research

Colorectal cancer under 20  years old: a retrospective analysis from three tertiary hospitals
ConclusionChild and adolescent CRC patients are likely to have distant metastasis, undifferentiated, left hemicolon location, and a dMMR/MSI-H phenotype at diagnosis. Additional efforts are needed to improve their survival outcomes. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 12, 2021 Category: Cancer & Oncology Source Type: research

Morphological, immune and genetic features in biopsy sample associated with the efficacy of pembrolizumab in patients with non-squamous non-small cell lung cancer
ConclusionAbsence of definitive morphological features in a biopsy sample could be a useful predictor of the efficacy of pembrolizumab in NSq NSCLC patients with tumor PD-L1 scores  ≥ 50%, as these tumors are likely to show high tumor PD-L1 expression and high TMB. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 12, 2021 Category: Cancer & Oncology Source Type: research

Retrospective analysis of data from 73 patients with childhood acute promyelocytic leukaemia receiving modified chemotherapy: a single-centre study
ConclusionsIdarubicin (8 –10 mg/m2/day for 2  days) for hyperleukocytosis control in induction therapy is safe and effective for paediatric APL. Risk-adapted attenuated consolidation chemotherapy is advocated. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 12, 2021 Category: Cancer & Oncology Source Type: research

Evaluation of the morphological features and unfavorable prognostic impact of dirty necrosis in renal cell carcinoma
AbstractPurposeTumor necrosis (TN) is one of the unfavorable prognostic factors in renal cell carcinoma (RCC). We identified two patterns of TN according to their morphology: dirty necrosis and ghost necrosis. We aimed to elucidate the morphological features and unfavorable prognostic impact of dirty necrosis in RCC.MethodsA total of 261 tumors collected after nephrectomy, which were pathologically identified as RCC, were analyzed in this study. We classified TN as dirty necrosis or ghost necrosis and compared their clinicopathological features. We also assessed their morphological features using digitally analyzed slides....
Source: Journal of Cancer Research and Clinical Oncology - March 12, 2021 Category: Cancer & Oncology Source Type: research

Prevalence and significance of M541L single nucleotide polymorphism in the central European cohort of gastrointestinal stromal tumor patients
ConclusionOur results do not support the association betweenKIT SNPM541L and increased risk of relapse in localized primary GISTs. Additionally, we found a positive correlation betweenKIT SNPM541L occurrence and earlier onset of relapse inPDGFRa and WT subgroup of GISTs. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 12, 2021 Category: Cancer & Oncology Source Type: research

Clinical outcomes in elderly rectal cancer patients treated with neoadjuvant chemoradiotherapy: impact of tumor regression grade
ConclusionOur results reported good tolerability and clinical outcomes of neoadjuvant CRT, with a benefit in patients  ≥ 70 years, confirming the prognostic role of pCR on clinical outcomes. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 12, 2021 Category: Cancer & Oncology Source Type: research

TERT promoter mutations in penile squamous cell carcinoma: high frequency in non-HPV-related type and association with favorable clinicopathologic features
ConclusionOur study showsTERT-p mutations are the most frequent somatic mutations in penile SCC. In addition,TERT-p mutations are far more frequent in non-HPV-related penile SCC than in HPV-related penile SCC, indicatingTERT-p mutations may have a role in tumorigenesis distinct from HPV-related penile SCC. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 12, 2021 Category: Cancer & Oncology Source Type: research

Does androgen-deprivation therapy increase the risk of ischemic cardiovascular and cerebrovascular diseases in patients with prostate cancer? A nationwide population-based cohort study
AbstractPurposeWe investigated whether ADT use was associated with the risk of ischemic cardiovascular diseases (CVD) and cerebrovascular diseases (CrVD) in a nationwide population-based cohort.MethodsClaims data of the Health Insurance and Review Assessment system in South Korea were used. In total, 195,308 men with newly diagnosed prostate cancer between January 1, 2008 and December 31, 2017 were identified. After applying the exclusion criteria, 131,189 men were enrolled. The study cohort was divided into ADT and non-ADT groups. Study outcomes were newly developed CVD, cardiovascular intervention (CVI), and CrVD. To con...
Source: Journal of Cancer Research and Clinical Oncology - March 12, 2021 Category: Cancer & Oncology Source Type: research

Reply to Andreas Boehle, Frank Kahmann, Thomas Oliver Henkel, Joerg Zimmermann and Stefan Machten ’s to the Letter to the editor Re: results of a randomized trial of treatment modalities in patients with low or early-intermediate risk prostate cancer (PREFERE trial)
(Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 12, 2021 Category: Cancer & Oncology Source Type: research

Re: Results of a randomized trial of treatment modalities in patients with low or early ‑intermediate risk prostate cancer (PREFERE trial)
AbstractThe authors of this “Letter to the Editors” express their major concern about selective and biased reporting in this paper. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 12, 2021 Category: Cancer & Oncology Source Type: research

New insights for precision treatment of glioblastoma from analysis of single-cell lncRNA expression
ConclusionIntratumoral heterogeneity may lead to poor prognosis or recurrence after treatment, and more precise typing of GBM can be performed based on single-cell lncRNA expression profiles. The biological characteristics possessed by different subtypes will have different effects on patients, such as survival time. For different subtypes, there are both drugs targeting single subtype and drugs targeting multiple subtypes, and we prefer drugs targeting multiple subtypes because this strategy can maximize medication efficiency and reduce the types of medication to reduce risks and side effects. (Source: Journal of Cancer R...
Source: Journal of Cancer Research and Clinical Oncology - March 11, 2021 Category: Cancer & Oncology Source Type: research

The mechanisms and reversal strategies of tumor radioresistance in esophageal squamous cell carcinoma
AbstractEsophageal squamous cell carcinoma (ESCC) is one of most lethal malignancies with high aggressive potential in the world. Radiotherapy is used as one curative treatment modality for ESCC patients. Due to radioresistance, the 5-year survival rates of patients after radiotherapy is less than 20%. Tumor radioresistance is very complex and heterogeneous. Cancer-associated fibroblasts (CAFs), as one major component of tumor microenvironment (TME), play critical roles in regulating tumor radioresponse through multiple mechanisms and are increasingly considered as important anti-cancer targets. Cancer stemness, which rend...
Source: Journal of Cancer Research and Clinical Oncology - March 9, 2021 Category: Cancer & Oncology Source Type: research

Application of four nutritional risk indexes in perioperative management for esophageal cancer patients
This study evaluated their properties in detecting compromised nutrition and guiding perioperative management of esophageal cancer patients.MethodsA prospective institutional database of esophageal cancer patients was reviewed and analyzed. Compromised nutritional status was defined as PNI  
Source: Journal of Cancer Research and Clinical Oncology - March 9, 2021 Category: Cancer & Oncology Source Type: research

Cancer patients ’ perspective on shared decision-making and decision aids in oncology
ConclusionsThere is a high demand for SDM but a lack of conclusive evidence on the specific information needs of different types of patients. Conversation between patients and clinicians needs encouragement and support. PDAs are designed for this purpose and have the potential to increase patient satisfaction. Their scarce use in consultations calls for easier access to and better information on PDAs for clinicians. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 7, 2021 Category: Cancer & Oncology Source Type: research

Assessment of individual molecular response in chronic myeloid leukemia patients with atypical BCR-ABL1 fusion transcripts: recommendations by the EUTOS cooperative network
ConclusionsCharacterization of atypicalBCR-ABL1 transcripts is essential for adequate patient monitoring and to avoid false-negative results. The results cannot be expressed on the International Scale (IS) and thus the common molecular milestones and guidelines for treatment are difficult to apply. We, therefore, suggest reporting IMR levels in these cases as a time-dependent log reduction ofBCR-ABL1 transcript levels compared to baseline prior to therapy. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 7, 2021 Category: Cancer & Oncology Source Type: research

Microsatellite instability (MSI-H) is associated with a high immunoscore but not with PD-L1 expression or increased survival in patients (pts.) with metastatic colorectal cancer (mCRC) treated with oxaliplatin (ox) and fluoropyrimidine (FP) with and without bevacizumab (bev): a pooled analysis of the AIO KRK 0207 and RO91 trials
AbstractIntroductionIn a retrospective analysis of two randomized phase III trials in mCRC patients treated first line with oxaliplatin, fluoropyrimidine with and without Bevacizumab (the AIO KRK 0207 and R091 trials) we evaluated the association of high microsatellite instability (MSI-H), immunoscore (IS) and PD-L1 expression in relation to overall survival (OS).MethodsIn total, 550 samples were analysed. Immunohistochemical analysis of the MMR proteins and additionally fragment length analysis was performed, molecular examinations via allele-discriminating PCR in combination with DNA sequencing. Furthermore PD-L1 and IS ...
Source: Journal of Cancer Research and Clinical Oncology - March 6, 2021 Category: Cancer & Oncology Source Type: research

Efficacy of three BCG strains (Connaught, TICE and RIVM) with or without secondary resection (re-TUR) for intermediate/high-risk non-muscle-invasive bladder cancers: results from a retrospective single-institution cohort analysis
ConclusionRe-TUR was confirmed to ensure longer RFS and PFS in intermediate-/high-risk NMIBCs but did not influence the relative single BCG strain efficacy. When routinely performing re-TUR followed by a maintenance BCG schedule, TICE was superior to the other strains for RFS outcomes. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 6, 2021 Category: Cancer & Oncology Source Type: research

Tumor patients ’ fears and worries and perceived changes of specific attitudes, perceptions and behaviors due to the COVID-19 pandemic are still relevant
ConclusionOncologists/psychologist have to know that patients ’ situation has not changed within the time of pandemic and that they still require information, close support and encouragement to rely on their resources to cope. Perceived changes are reflecting coping strategies that could be trained to increase patients’ resilience during further pandemic w aves. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 6, 2021 Category: Cancer & Oncology Source Type: research

Clinical feasibility and oncologic safety of primary endoscopic submucosal dissection for clinical submucosal invasive early gastric cancer
ConclusionIn this study, 173 (56.4%) out of 307 patients with cT1bN0M0 gastric cancer could avoid unnecessary surgery if primary endoscopic submucosal dissection was used. Based on these findings, it is necessary to add an appropriate indication for endoscopic submucosal dissection in patients with cT1b gastric cancer. Further management could be determined based on pathologic findings after primary endoscopic submucosal dissection. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 5, 2021 Category: Cancer & Oncology Source Type: research

Exploring the role of BAFF as biomarker in the detection of uveal melanoma metastases
ConclusionsOur study first suggests that BAFF might be a promising serum marker for the detection of UM metastases. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 4, 2021 Category: Cancer & Oncology Source Type: research

Are there sex differences among colorectal cancer patients in treatment and survival? A Swiss cohort study
ConclusionThe probability of receiving any primary treatment and survival were independent of sex. However, female CRC patients with the highest CCI appeared more likely to receive other therapy than surgery compared to their male counterparts. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 4, 2021 Category: Cancer & Oncology Source Type: research

Sphingosine-kinase-1 expression is associated with improved overall survival in high-grade serous ovarian cancer
ConclusionOur data identify high levels of SPHK1 expression as a potential favorable prognostic marker in ovarian cancer patients. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 3, 2021 Category: Cancer & Oncology Source Type: research

Performance of international prognostic indices in plasmablastic lymphoma: a comparative evaluation
ConclusionOur current observations support the use of the IPI and its enhanced derivatives in PBL patients. There is, however, a distinct requirement for novel prognostic tools to better delineate subgroups at risk for early relapse or refractory disease as well as late relapse. A comprehensive molecular characterization of a clinically annotated cohort of PBL patients is therefore urgently warranted. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 3, 2021 Category: Cancer & Oncology Source Type: research

Early T-cell precursor acute lymphoblastic leukemia and other subtypes: a retrospective case report from a single pediatric center in China
ConclusionCompared with other subtypes, pediatric ETP-ALL had a poor treatment response and high recurrence rate while cortical T-ALL appeared to have much better outcome. Our observations highlight the need for an individualized treatment regime for ETP-ALL. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 2, 2021 Category: Cancer & Oncology Source Type: research

Blockage of glioma cell survival by truncated TEAD-binding domain of YAP
ConclusionYAPBD can block glioma cell survival and repress YAP-dependent gene expressions, indicating gene therapy which targets TEAD-YAP complex would be a potential and significant novel approach for human malignant gliomas. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 2, 2021 Category: Cancer & Oncology Source Type: research

Elotuzumab spares dendritic cell integrity and functionality
(Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 2, 2021 Category: Cancer & Oncology Source Type: research

Hypofractionated sequential radiotherapy boost: a promising strategy in inoperable locally advanced pancreatic cancer patients
ConclusionTreatment intensification with hypofractionated radiotherapy boost is well tolerated in pts affected by unresectable LAPC previously treated with CT/CRT. Its rates of local and pain control are encouraging, supporting its introduction in clinical practice. Timing, schedule and dose of HRB need to be further investigated to personalize therapy and optimize clinical advantages. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 9, 2021 Category: Cancer & Oncology Source Type: research

Using etoposide  + dexamethasone-based regimens to treat nasal type extranodal natural killer/T-cell lymphoma-associated hemophagocytic lymphohistiocytosis
AbstractPurposeNasal type extranodal natural killer/T-cell lymphoma (ENKTL) can be associated with hemophagocytic lymphohistiocytosis (NK/T-LAHLH), which is a rare and fatal disease with no effective therapy. We evaluated whether etoposide  + dexamethasone-based chemotherapy regimens might be useful for treating NK/T-LAHLH.MethodsThis retrospective single-center study evaluated clinical data from 37 patients with NK/T-LAHLH who were treated between May 2008 and January 2020.ResultsAmong 363 patients with ENKTL, the cumulative incidence of HLH was 11.9%. Among 43 patients with NK/T-LAHLH, 37 patients received ...
Source: Journal of Cancer Research and Clinical Oncology - February 9, 2021 Category: Cancer & Oncology Source Type: research

Emerging role of exosomes and exosomal microRNA in cancer: pathophysiology and clinical potential
ConclusionThese data suggest that exosomes and exosomal microRNA are directly related to cancer progression mechanisms, and could be used in cancer early diagnosis, prognosis, and therapy. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 9, 2021 Category: Cancer & Oncology Source Type: research