Breast cancer: an update on treatment-related infertility
AbstractBreast cancer (BC) is the most common malignancy in women with a significant increasing incidence during the reproductive life. However, based on the newest anti-cancer molecular targeting drugs, successful treatments lead to the disease healing particularly in young patients, thus refreshing their motherhood programs. However, as effect of the BC treatment, a premature depletion of the ovarian follicle reserve occurs in more than one-third of patients resulting in permanent infertility. To prevent the cancer treatment-related infertility (CTRI), several options are today utilized. Besides the ovary suppression by ...
Source: Journal of Cancer Research and Clinical Oncology - February 25, 2020 Category: Cancer & Oncology Source Type: research

Cell cycle progression score improves risk stratification in prostate cancer patients with adverse pathology after radical prostatectomy
AbstractObjectiveTo assess the use of the cell cycle progression (CCP) score versus actual risk stratification practice in making treatment decisions for prostate cancer patients with locally adverse pathology after radical prostatectomy (RP).Patients and methodsMen with adverse pathologic features, pT3 or positive surgical margins who underwent RP in 2010 –2014 at Renji hospital were retrospectively analyzed. The primary outcome was biochemical recurrence (BCR) after RP. RNA was quantified from paraffin-embedded RP specimens. The CCP score was calculated as average expression of 31 CCP genes, normalized to 15 housek...
Source: Journal of Cancer Research and Clinical Oncology - February 25, 2020 Category: Cancer & Oncology Source Type: research

Bevacizumab versus alkylating chemotherapy in recurrent glioblastoma
AbstractBackgroundThe use of alkylating chemotherapy versus bevacizumab for recurrent glioblastoma remains controversial. Here, we tested the hypothesis that the activity of alkylators, but not that of bevacizumab, would be associated with theO6-methylguanine DNA methyltransferase (MGMT) promoter methylation status.MethodsWe analyzed a cohort of patients treated at centers of the German Glioma Network or the University Hospital Zurich with alkylating agent-based chemotherapy (n = 260) or bevacizumab without or with irinotecan (n = 84) for first recurrence of glioblastoma. Outcome was stratified ...
Source: Journal of Cancer Research and Clinical Oncology - February 25, 2020 Category: Cancer & Oncology Source Type: research

Decision tree algorithm in locally advanced rectal cancer: an example of over-interpretation and misuse of a machine learning approach
AbstractPurposeTo analyse the classification performances of a decision tree method applied to predictor variables in survival outcome in patients with locally advanced rectal cancer (LARC). The aim was to offer a critical analysis to better apply tree-based approach in clinical practice and improve its interpretation.Materials and methodsData concerning patients with histological proven LARC between 2007 and 2014 were reviewed. All patients were treated with trimodality approach with a curative intent. The Kaplan –Meier method was used to estimate overall survival (OS). Decision tree methods were was used to select ...
Source: Journal of Cancer Research and Clinical Oncology - February 25, 2020 Category: Cancer & Oncology Source Type: research

A high serum-free fatty acid level is associated with cancer
ConclusionOur study provides clinical evidence to support that fatty acid metabolism is associated with cancers and demonstrates that a high FFA level in the serum may be an indicator of cancer. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 25, 2020 Category: Cancer & Oncology Source Type: research

Treatment and survival of primary intracranial germ cell tumors: a population-based study using SEER database
ConclusionIn germinomas, radiotherapy alone had superior survival outcomes compared to biopsy and resection, but no change in survival when compared to chemotherapy alone. Addition of radiotherapy or chemotherapy did not improve survival in MTs when compared to resection alone. Adding chemotherapy in NGGCT patients undergoing resection improved survival compared to resection alone. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 25, 2020 Category: Cancer & Oncology Source Type: research

Fluzoparib increases radiation sensitivity of non-small cell lung cancer (NSCLC) cells without BRCA1/2 mutation, a novel PARP1 inhibitor undergoing clinical trials
ConclusionThe potential therapeutic value of fluzoparib for increasing the radiation sensitivity of NSCLC is well confirmed. Moreover, our findings of high mutation frequencies among HR genes suggest that PARP1 inhibition may be an effective treatment strategy for advanced non-small cell lung cancer patients. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 25, 2020 Category: Cancer & Oncology Source Type: research

Stereotactic body radiotherapy for elderly patients ( ≥ 75 years) with early-stage non-small cell lung cancer
AbstractPurposeStereotactic body radiotherapy (SBRT) is the primary treatment method for early-stage non-small cell lung cancer (NSCLC) considered inoperable due to medical comorbidities. However, the application of SBRT in patients aged  ≥ 75 years has not been adequately studied. This retrospective study aimed to investigate the effectiveness and safety of SBRT in early-stage NSCLC patients aged ≥ 75 years, and the impact of treatment on nutritional status and self-care ability.MethodsHistopathologically confirmed early-stage (T1-3N0M0) NSCLC patients aged  ≥ 7...
Source: Journal of Cancer Research and Clinical Oncology - February 24, 2020 Category: Cancer & Oncology Source Type: research

Optimal method for measuring invasive size that predicts survival in invasive mucinous adenocarcinoma of the lung
ConclusionsELM has higher discriminative power for OS, and thus the optimal method for measuring the pathological invasive size of IMA should exclude the lepidic component regardless of alveolar mucin. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 22, 2020 Category: Cancer & Oncology Source Type: research

Aloperine in combination with therapeutic adenoviral vector synergistically suppressed the growth of non-small cell lung cancer
ConclusionIn conclusion, ALO –Adbic combination can produce synergistic anti-cancer effects at low doses, and may offer a more effective and less toxic new treatment strategy for NSCLC. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 22, 2020 Category: Cancer & Oncology Source Type: research

Real-life multidisciplinary treatment for unresectable colorectal cancer liver metastases including hepatic artery infusion with chemo-filtration and liquid biopsy precision oncotherapy: observational cohort study
AbstractBackgroundHepatic artery infusion (HAI) and drug selection by liquid biopsy precision oncotherapy are under investigation for the multidisciplinary treatment of unresectable colorectal liver metastases (CRCLM) in progression after systemic therapy. Here, we compare the safety and efficacy of third-line HAI followed by target therapy with drug regimes selected by liquid biopsy precision oncotherapy to third-line systemic therapy with drug regimes selected partly by tissue biopsy precision oncotherapy, in a retrospective real-life study of 106 unresectable CRCLM patients.MethodsDrug regimens for HAI/target therapy we...
Source: Journal of Cancer Research and Clinical Oncology - February 22, 2020 Category: Cancer & Oncology Source Type: research

Hemophagocytic lymphohistiocytosis in adults: collaborative analysis of 137 cases of a nationwide German registry
AbstractPurposeHemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome emerging from a deregulated immune response due to various triggers. In adults, systematic data are sparse, which is why recommendations on diagnosis and management have been adopted from pediatric guidelines. A nationwide clinical registry with associated consulting service as collaborative initiative of HLH-specialized pediatricians and hematologists was initiated to better characterize HLH in adults.MethodsPatients with proven or suspected HLH were registered by 44 institutions. Both HLH-2004 diagnostic criteria and the HScore...
Source: Journal of Cancer Research and Clinical Oncology - February 20, 2020 Category: Cancer & Oncology Source Type: research

Volume de-escalation in radiation therapy: state of the art and new perspectives
ConclusionFurther clinical trials are necessary to improve the identification of suitable patient cohorts and the extent of possible volume de-escalation that does not compromise tumor control. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 18, 2020 Category: Cancer & Oncology Source Type: research

A transcriptional metabolic gene-set based prognostic signature is associated with clinical and mutational features in head and neck squamous cell carcinoma
Conclusion6MPS functions not only as a promising predictor of prognosis and survival but also as potential marker for therapeutic schedule monitoring. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 17, 2020 Category: Cancer & Oncology Source Type: research

New advances in antiangiogenic combination therapeutic strategies for advanced non-small cell lung cancer
ConclusionsAntiangiogenic agents can achieve therapeutic benefit in advanced NSCLC patients and the combination of chemotherapy, targeted therapy or immunotherapy can lead to synergistic effect. However, exploring the best combination therapy and efficacy-related biomarkers needs further study. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 17, 2020 Category: Cancer & Oncology Source Type: research

Radiomic profiles in diffuse glioma reveal distinct subtypes with prognostic value
ConclusionA radiomic model derived from multi-parameter MRI of the gliomas was successful in the risk stratification of diffuse glioma patients. These data suggested that radiomics provided an alternative approach for survival estimation and may improve clinical decision-making. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 17, 2020 Category: Cancer & Oncology Source Type: research

Clinical characteristics and outcomes of SDHB -related pheochromocytoma and paraganglioma in children and adolescents
ConclusionThe present report has highlighted several important aspects in the management of pediatric patients withSDHB mutations associated-PHEO/PGL. Initial diagnostic evaluation ofSDHB mutation carriers should be started at age of 5 –6 years with initial work-up focusing on abdominal region. Thorough follow-up is crucial first 2 years post-diagnosis and more frequent follow-ups are needed in years 10–20 post-diagnosis due to the increased risk of metastases. Although this age group developed metastasis as early as 5 year s from diagnosis, we have shown that the overall 20-year prognosis and su...
Source: Journal of Cancer Research and Clinical Oncology - February 15, 2020 Category: Cancer & Oncology Source Type: research

A novel DNA damage response signature of IDH-mutant grade II and grade III astrocytoma at transcriptional level
ConclusionWe developed a two-gene signature which can effectively predict the prognosis of patients with IDH-mutant grade II and grade III astrocytoma. It suggests a novel classification of astrocytoma with better prognostic accuracy based on the expression of DNA damage response genes. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 14, 2020 Category: Cancer & Oncology Source Type: research

Thoracic solitary fibrous tumors: an analysis of 70 patients who underwent surgical resection in a single institution
ConclusionThe gold standard of TSFT treatment is complete surgical resection. VATS is safe and reliable for treating selected TSFT patients. Aggressive surgical resection could be underwent in such patients of local recurrence or solitary metastatic tumor. A long-term follow-up is necessary due to the risk of recurrence. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 14, 2020 Category: Cancer & Oncology Source Type: research

Antiemetic prophylaxis with fosaprepitant and granisetron in pediatric patients undergoing allogeneic hematopoietic stem cell transplantation
AbstractBackground Chemotherapy-induced nausea and vomiting (CINV) is a severe and distressing complication during allogeneic hematopoietic stem cell transplantation (alloHSCT). The antiemetic fosaprepitant has shown favorable results in pediatric and adult patients receiving chemotherapy. Data on fosaprepitant in children and adolescents undergoing alloHSCT are missing.MethodsIn this non-interventional observation study, 120 children and adolescents with a median age of 11.8  years undergoing alloHSCT after a moderately or highly emetogenic conditioning (MEC or HEC) were analyzed. They received an antiemetic prophy...
Source: Journal of Cancer Research and Clinical Oncology - February 13, 2020 Category: Cancer & Oncology Source Type: research

Recursive partitioning model-based analysis for survival of colorectal cancer patients with lung and liver oligometastases treated with stereotactic body radiation therapy
ConclusionsStereotactic body radiation therapy can be considered an effective treatment for the management of liver and lung metastases from CRC. With RPA, we identified prognostic risk class to define patients who could benefit the most from SBRT. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 13, 2020 Category: Cancer & Oncology Source Type: research

Restoration of MARCK enhances chemosensitivity in cancer
ConclusionsCells devoid of MARCKS function showed incomplete ABCB1 internalization, leading to higher ABCB1 activity enhancing chemoresistance. Vice versa our data suggest the prevention of MARCKS inhibition by reversing hyperphosphorylation or genomic restoration after deletion as two promising approaches to overcome tumor cell resistance towards chemotherapeutic ABCB1 substrates. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 13, 2020 Category: Cancer & Oncology Source Type: research

The immune-metabolic-prognostic index and clinical outcomes in patients with non-small cell lung carcinoma under checkpoint inhibitors
AbstractPurposeThis prospective study evaluated whether peripheral blood biomarkers and metabolic parameters on F-18 fludeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) could be associated with clinical outcome in non-small cell lung carcinoma (NSCLC) patients treated with immune checkpoint inhibitors (ICI).MethodsData from 33 patients with NSCLC and treated with ICI were collected. Complete blood cell counts before and at the first restaging were measured. All patients underwent F-18 FDG PET/CT at baseline, while 25 patients at the first restaging. Progression-free survival (PFS) and overall...
Source: Journal of Cancer Research and Clinical Oncology - February 11, 2020 Category: Cancer & Oncology Source Type: research

Guidelines for uveal melanoma: a critical appraisal of systematically identified guidelines using the AGREE II and AGREE-REX instrument
ConclusionThe UK guideline achieved the highest scores with both instruments and may serve as a basis for future guideline development in UM. The domains “editorial independence”, “recommendation”, and “applicability” were identified as methodological weaknesses and require particular attention and improvement in future guidelines. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 8, 2020 Category: Cancer & Oncology Source Type: research

Peri-operative chemotherapy for resectable colorectal lung metastasis: a systematic review and meta-analysis
AbstractPurposeSeveral studies have evaluated surgical resection of pulmonary metastases as a standard treatment option for colorectal cancer (CRC) patients with resectable pulmonary metastases.  However, the role of peri-operative chemotherapy after complete resection of pulmonary metastases from CRC patients is still controversial. This systematic review and meta-analysis is aimed to investigate the clinical efficacy of peri-operative chemotherapy after resection of CRC pulmonary metasta ses.MethodsPubMed, the Cochrane Library databases, and Embase were searched for studies evaluating the effect of peri-operative ch...
Source: Journal of Cancer Research and Clinical Oncology - February 8, 2020 Category: Cancer & Oncology Source Type: research

New HER2-negative breast cancer subtype responsive to anti-HER2 therapy identified
ConclusionsThe CELx HSF test is a well-characterized functional biomarker assay capable of identifying dynamic HER2-driven signaling dysfunction in tumor cells from HER2-negative breast cancer patients. This test has demonstrated efficacy of various HER2 targeted therapies in live tumor cells from the HSFs+  population and correlated the test result to HER2 drug response in mouse xenograft studies. The proportion of HER2-negative breast cancer patients found to have abnormal HER2 signaling in a 114 patient sample study, 20–25%, is significant. A clinical trial to evaluate the efficacy of anti-HER2 therapies in...
Source: Journal of Cancer Research and Clinical Oncology - February 8, 2020 Category: Cancer & Oncology Source Type: research

LOC646329 long non-coding RNA sponges miR-29b-1 and regulates TGF β signaling in colorectal cancer
AbstractNon-coding RNAs (ncRNAs) are reported to be regulators of signaling pathways that are involved in colorectal cancer (CRC) progression. Aiming at finding ncRNAs (miRNAs) that are differentially expressed in tumor versus normal colorectal tissue samples, online RNA-seq data were analyzed. Of between 18 candidate miRNAs,hsa-miR-29b-1 (miR-29b-1) represented the highest fold change of expression level.Hsa-miR-29b-1 is encoded from the third intron ofLOC646329 long ncRNA gene. Surprisingly, twomiR-29b sponging sites were predicted within exons ofLOC646329 gene. Then, dual luciferase assay supported the interaction ofmiR...
Source: Journal of Cancer Research and Clinical Oncology - February 7, 2020 Category: Cancer & Oncology Source Type: research

The PI3K pathway impacts stem gene expression in a set of glioblastoma cell lines
ConclusionGiven that, PI3K inhibitors are actively investigated as targeted cancer therapies, the FOXO-mediated induction of stem genes observed in this study highlights a potential hazard to PI3K inhibition. Understanding the molecular underpinnings of stem signatures in cancer will allow refinements to therapeutic strategies. Targeting FOXO factors to reduce stem cell characteristics in concert with PI3K inhibition may prove therapeutically efficacious. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 6, 2020 Category: Cancer & Oncology Source Type: research

MYC/BCL2/BCL6 triple hit lymphoma of the pericardium: a case report and review of the literature
(Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 6, 2020 Category: Cancer & Oncology Source Type: research

PD-L1 expression and survival in p16-negative and -positive squamous  cell carcinomas of the vulva
AbstractAimProgrammed death-ligand 1 (PD-L1) has become a widely used predictive biomarker for therapy with checkpoint inhibitors in a variety of cancers. Here, we studied the expression of PD-L1 in squamous  cell carcinomas of the vulva (SCCV) with regard to HPV status via its surrogate marker p16. Additionally, the status of PD-L1 and p16 were analyzed for prognostic information and potential correlation to tumor-infiltrating lymphocytes (TILs).MethodsPD-L1 was analyzed in 128 cases of SCCV using the tumor proportion score (TPS), the immune cell score (ICS) and the combined positive score (CPS). Cases were immunosta...
Source: Journal of Cancer Research and Clinical Oncology - February 5, 2020 Category: Cancer & Oncology Source Type: research

Clinical impact of skeletal muscle area in patients with non-small cell lung cancer treated with anti-PD-1 inhibitors
ConclusionsL3 muscle indexLow is an independent predictor of worse outcomes in NSCLC patients treated with anti-PD-1 inhibitors. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 5, 2020 Category: Cancer & Oncology Source Type: research

Overexpression of the human cytomegalovirus UL111A is correlated with favorable survival of patients with gastric cancer and changes T-cell infiltration and suppresses carcinogenesis
ConclusionsHigh UL111A expression changes the number of infiltrating T cells and is associated with favorable survival. Therefore, UL111A could be used as an independent prognostic biomarker and might be a potential therapeutic target for GC. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 5, 2020 Category: Cancer & Oncology Source Type: research

Impact of pathologic complete response on survival after neoadjuvant chemotherapy in early-stage breast cancer: a population-based analysis
ConclusionsAchieving pCR after neoadjuvant chemotherapy was associated with clinically meaningful improvements in survival parameters in a real-world setting. The cumulative data support pCR as a valid surrogate endpoint in both clinical trials and population-based settings. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 28, 2020 Category: Cancer & Oncology Source Type: research

Transcriptome analysis reveals overlap in fusion genes in a phase I clinical cohort of TNBC and HGSOC patients treated with buparlisib and olaparib
ConclusionsIn summary, this study provides the first characterization of fusion genes in a cohort of TNBC and HGSOC patients. An improved mechanistic understanding of fusion genes will support the future identification of innovative therapeutic approaches for these challenging diseases. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 28, 2020 Category: Cancer & Oncology Source Type: research

Clinical outcomes and prognostic factors of stereotactic body radiation therapy combined with gemcitabine plus capecitabine for locally advanced unresectable pancreatic cancer
This study aimed to evaluate the clinical outcomes, toxicity, and prognostic factors of SBRT combined with gemcitabine plus capecitabine (GEM-CAP) in treating locally advanced pancreatic cancer (LAPC).MethodsA total of 56 patients with LAPC treated with SBRT combined with GEM-CAP were reviewed from October 2010 to October 2016. The median total prescription dose at five fractions was 40  Gy (30–50 Gy). The patients were subjected to two cycles of GEM-CAP before SBRT. GEM-CAP chemotherapy was then offered for four cycles or until disease tolerance or progression. The primary endpoints included overall surviv...
Source: Journal of Cancer Research and Clinical Oncology - January 28, 2020 Category: Cancer & Oncology Source Type: research

Prolonged time to treatment initiation in advanced pancreatic cancer patients has no major effect on treatment outcome: a retrospective cohort study controlled for lead time bias and waiting time paradox
ConclusionWhile a timely work-up of advanced PC patients remains important, delays in treatment initiation due to repeated biopsies, inclusion in a clinical study or transfer to a specialized cancer center appear to be justified in light of the absence of a strong adverse effect of prolonged TTI on prognosis in advanced PC patients. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 28, 2020 Category: Cancer & Oncology Source Type: research

Treatment patterns and survival after 18F-fluorodeoxyglucose positron emission tomography/computed tomography-guided local consolidation therapy for oligometastatic non-small cell lung cancer: a two-center propensity score-matched analysis
ConclusionWe concluded that LCT was significantly associated with improved clinical outcomes among the Chinese patients with oligometastatic NSCLC who were eligible for systemic treatment and could undergo PET/CT evaluation. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 25, 2020 Category: Cancer & Oncology Source Type: research

An increased bone mineral density is an adverse prognostic factor in patients with systemic mastocytosis
AbstractPurposeSystemic mastocytosis (SM) is characterized by the expansion of clonal mast cells that infiltrate various organ systems. The extent of organ infiltration and subsequent organ damage distinguishes between indolent SM (ISM) defined by a nearly normal life expectancy and advanced SM (AdvSM) defined by poor prognosis. In ISM, measurement of the bone mineral density (BMD) frequently reveals osteoporosis. In contrast, the clinical implication of an increased BMD and osteosclerosis remains unclear.MethodsBMD was evaluated in 61 patients with mastocytosis (ISM,n = 29, 48%; AdvSM,n = 32, 5...
Source: Journal of Cancer Research and Clinical Oncology - January 24, 2020 Category: Cancer & Oncology Source Type: research

“Hedgehog pathway”: a potential target of itraconazole in the treatment of cancer
ConclusionAs a new anticancer drug, whether itraconazole eventually entering clinical application requires the joint eforts of all scholars. In any case, an in-depth study on itraconazole will bring new hope for cancer patients in the near future. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 20, 2020 Category: Cancer & Oncology Source Type: research

TERT promoter hotspot mutations and their relationship with TERT levels and telomere erosion in patients with head and neck squamous cell carcinoma
ConclusionTERT promoter mutations are most likely a late event in tumor development, occurring in a context of critically short telomeres, mostly in patients with oral cavity SCC.TERT levels, but notTERT promoter mutational status impact clinical outcome. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 20, 2020 Category: Cancer & Oncology Source Type: research

How to bridge the gap? European medical plants used for treating oral mucositis: on the search for evidence
ConclusionClinical trials investigating medical plants known in TEM are rare. However, following our research strategy, we could extrapolate four plants with good evidence for alleviating symptoms of oral mucositis and gingivitis. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 18, 2020 Category: Cancer & Oncology Source Type: research

Long non-coding RNA MALAT1 facilitates the tumorigenesis, invasion and glycolysis of multiple myeloma via miR-1271-5p/SOX13 axis
ConclusionLncRNA MALAT1 expedited MM tumorigenesis, invasion, and glycolysis via miR-1271-5p/SOX13 axis. MALAT1 might contribute to the therapy of MM as a promising indicator. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 18, 2020 Category: Cancer & Oncology Source Type: research

Clinical features and treatment of 7 Chinese TAFRO syndromes from 96 de novo Castleman diseases: a 10-year retrospective study
ConclusionsThis study reveals that TAFRO syndrome is more severe and has more systemic symptoms than other iMCD, most cases need active treatment, and their prognoses are poor. Lenalidomide based regimen may be as a promising new therapy for TAFRO syndrome. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 14, 2020 Category: Cancer & Oncology Source Type: research

Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS)
AbstractBackgroundOlder age is associated with worse outcome in synovial sarcoma (SS) patients. Differences in disease presentation among distinct age groups, however, are currently unknown.MethodsSS patients    10 cm was higher (13%, 21%, 31%;p = 0.005657) whereas conversely, the proportion of small tumors 
Source: Journal of Cancer Research and Clinical Oncology - January 13, 2020 Category: Cancer & Oncology Source Type: research

Histone deacetylase inhibitors dysregulate DNA repair proteins and antagonize metastasis-associated processes
ConclusionHDACi suppress the epithelial –mesenchymal transition (EMT) and compromise the DNA integrity of cancer cells. These data encourage further testing of HDACi against tumor cells. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 13, 2020 Category: Cancer & Oncology Source Type: research

Mesonephric-like adenocarcinomas of the uterine corpus: report of a case series and review of the literature indicating poor prognosis for this subtype of endometrial adenocarcinoma
ConclusionUterine ML-AC represents a distinct subtype of invasive endometrial AC, associated withKRAS-mutations and characteristic immunohistochemical findings. Clinically, ML-AC may show an aggressive behavior with a high rate of recurrent disease and a substantial risk for distant metastatic disease, especially to the lungs. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 11, 2020 Category: Cancer & Oncology Source Type: research

Myeloid sarcoma is associated with poor clinical outcome in pediatric patients with acute myeloid leukemia
AbstractPurposeThe impact of myeloid sarcoma (MS) on clinical outcome of pediatric acute myeloid leukemia (AML) patients remains controversial. Moreover, little is known about the role of stem cell transplantation (SCT) in such patients.MethodsClinical data of patients with AML under 18  years of age were retrieved from the TARGET dataset. We analyzed the prevalence, clinical profile, molecular characteristics, and prognosis of MS in these patients.ResultsAmong 884 pediatric patients with AML, the frequency of MS was 12.3%. Pediatric AML with MS was associated with age under 1-year, abnormal cytogenetics, andKMT2A rea...
Source: Journal of Cancer Research and Clinical Oncology - January 9, 2020 Category: Cancer & Oncology Source Type: research

Percent tumor volume vs American Joint Committee on Cancer staging system subclassification for predicting biochemical recurrence in patients with pathologic T2 prostate cancer
AbstractPurposeHere, we re-checked the American Joint Committee on Cancer 7th edition subclassification and confirmed the possibility of percent tumor volume as a prognostic factor for biochemical recurrence in the 8th edition subclassification.MethodsA total of 1073 patients with pathologic T2 stage disease who underwent radical prostatectomy were included. Exclusion criteria were neoadjuvant therapy and pathologic T3 and N1 disease. Biochemical recurrence-free survival was estimated using the Kaplan –Meier method. Cox hazard regression was used to predict biochemical recurrence.ResultsAccording to the 7th edition s...
Source: Journal of Cancer Research and Clinical Oncology - January 8, 2020 Category: Cancer & Oncology Source Type: research

25-Hydroxy vitamin D deficiency predicts inferior prognosis in mantle cell lymphoma
AbstractIntroductionMantle cell lymphoma (MCL) is a subtype of B-cell non-Hodgkin lymphoma (NHL), and the purpose of this study was to evaluate the prognostic value of 25-hydroxy vitamin D [25-(OH)D] deficiency among patients with MCL.Materials and methodsSeventy MCL patients with serum 25-(OH)D were enrolled in this study. 25-(OH)D deficiency was defined as a 25-(OH)D level lower than 50  nmol/L, according to International standard of 25-(OH)D classification. The univariate and multivariate Cox regression analyses were used to define the prognostic factors associated with progression-free survival (PFS) and overall s...
Source: Journal of Cancer Research and Clinical Oncology - January 8, 2020 Category: Cancer & Oncology Source Type: research

YARS as an oncogenic protein that promotes gastric cancer progression through activating PI3K-Akt signaling
ConclusionsBy revealing the existence of a YARS-PI3K-Akt signaling axis in gastric cancer, we discovered that tRNA synthetase YARS is a novel tumorigenic factor, characterized by its upregulation in tumor-derived specimens, as well as its functions in promoting gastric cancer progression. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 8, 2020 Category: Cancer & Oncology Source Type: research