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MID1 –PP2A complex functions as new insights in human lung adenocarcinoma
ConclusionsWe demonstrated that the MID1 –PP2A complex plays an important role in lung adenocarcinoma, influencing cell cycle progression, proliferation and apoptosis. Our findings showed a novel molecular mechanism of lung tumorigenesis that may provide new insights for anti-tumor therapies. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 15, 2018 Category: Cancer & Oncology Source Type: research

Author Correction: Exploratory analyses assessing the impact of early tumour shrinkage and depth of response on survival outcomes in patients with RAS wild-type metastatic colorectal cancer receiving treatment in three randomised panitumumab trials
AbstractThe authors would like to include the following changes in the published article. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 15, 2018 Category: Cancer & Oncology Source Type: research

Second primary colorectal cancer among endometrial cancer survivor: shared etiology and treatment sequelae
AbstractPurposeTo evaluate the incidence of colon cancer as a second primary cancer (CCSPC) and the survival outcomes of women with and without CCSPC after the diagnosis of endometrial cancer (EC).MethodsThe standardized incidence ratio (SIR) of CCSPC and survival outcomes of EC survivors with and without CCSPC were analyzed using data from January 1 1993 to December 31 2011, obtained from the Korea Central Cancer Registry.ResultsOf 14,797 EC survivors, 147 (0.99%) developed CCSPC after an average interval of 5.5  years. The SIR of CCSPC among EC survivors was 2.56, higher than that of colon cancer in the general popu...
Source: Journal of Cancer Research and Clinical Oncology - February 14, 2018 Category: Cancer & Oncology Source Type: research

Modern intensity-modulated radiotherapy with image guidance allows low toxicity rates and good local control in chemoradiotherapy for anal cancer patients
ConclusionsModern intensity-modulated radiotherapy with daily image-guided radiotherapy is effective and safe in treating anal cancer patients and should be considered the standard of care in this clinical setting. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 13, 2018 Category: Cancer & Oncology Source Type: research

Targeting of glutamine transporter ASCT2 and glutamine synthetase suppresses gastric cancer cell growth
ConclusionGln mediates GC growth and the therapeutic efficacy of Gln-targeted treatment relies on distinct ASCT2 and GS expression pattern in specific gastric cancer groups. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 12, 2018 Category: Cancer & Oncology Source Type: research

Immunosuppressive tumor microenvironment of usual interstitial pneumonia-associated squamous cell carcinoma of the lung
AbstractPurposePatients with usual interstitial pneumonia (UIP) often develop lung cancer. However, the biological features of lung cancer associated with UIP remain unknown. The aim of this study was to elucidate the clinicopathological characteristics of UIP-associated squamous cell carcinoma (SqCC).MethodsA total of 244 patients with p-stage I lung SqCC who underwent complete surgical resection were enrolled in this study. Clinicopathological differences between UIP-associated SqCC and non-UIP SqCC were examined. Moreover, we performed immunohistochemical studies to clarify the biological differences between these two g...
Source: Journal of Cancer Research and Clinical Oncology - February 12, 2018 Category: Cancer & Oncology Source Type: research

Treatment with 5-azacitidine delay growth of glioblastoma xenografts: a potential new treatment approach for glioblastomas
ConclusionsOur data show significant growth inhibition as well as antiangiogenic effects in intracerebral as well as patient-derived GBM xenografts. This encourages to investigate in detail the multifactorial effects of 5-azacitidine on glioblastomas. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 9, 2018 Category: Cancer & Oncology Source Type: research

A study of association of Oncotype DX recurrence score with DCE-MRI characteristics using multivariate machine learning models
AbstractPurposeTo determine whether multivariate machine learning models of algorithmically assessed magnetic resonance imaging (MRI) features from breast cancer patients are associated with Oncotype DX (ODX) test recurrence scores.MethodsA set of 261 female patients with invasive breast cancer, pre-operative dynamic contrast enhanced magnetic resonance (DCE-MR) images and available ODX score at our institution was identified. A computer algorithm extracted a comprehensive set of 529 features from the DCE-MR images of these patients. The set of patients was divided into a training set and a test set. Using the training set...
Source: Journal of Cancer Research and Clinical Oncology - February 9, 2018 Category: Cancer & Oncology Source Type: research

Long-term efficacy of ultrasound-guided low power microwave ablation for the treatment of primary papillary thyroid microcarcinoma: a 3-year follow-up study
ConclusionsAfter a long-term follow-up of 3  years, the low power MWA showed a good safety and efficacy for the treatment of PTMC. In addition to surgery and active surveillance, MWA might be another alternative for patients with PTMC. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 9, 2018 Category: Cancer & Oncology Source Type: research

Ballroom dancing as physical activity for patients with cancer: a systematic review and report of a pilot project
ConclusionBallroom dancing may offer benefits for patients with respect to quality of life. Cancer patients prefer sheltered training setting and curricula of regular ballroom classes must be adapted for cancer patients. Strict curricula might reduce motivation and adherence and exclude patients with lower or variable fitness. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 8, 2018 Category: Cancer & Oncology Source Type: research

Generation of erythroid cells from polyploid giant cancer cells: re-thinking about tumor blood supply
ConclusionAn alternative embryonic pathway to obtain oxygen in cancer cells exists, particularly when they are under hypoxic conditions. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 7, 2018 Category: Cancer & Oncology Source Type: research

Impact of comorbidities at diagnosis on prostate cancer treatment and survival
ConclusionsThe results of the current study suggest that chronological age is a stronger predictor of treatment choices than comorbidities, although comorbidities have a larger influence on patients ’ mortality. Hence, inclusion of comorbidities in treatment choices may provide more appropriate treatment for PCa patients to counteract over- or undertreatment. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 7, 2018 Category: Cancer & Oncology Source Type: research

Oncological effect of palliative transurethral resection of the prostate in patients with advanced prostate cancer: a propensity score matching study
AbstractPurposeWe investigated the oncologic effect of palliative transurethral resection of the prostate (pTURP) in patients with prostate cancer who received primary androgen deprivation therapy.MethodsWe reviewed 614 patients, including 83 who underwent pTURP; those with incidental prostate cancer were excluded. Patients were divided into the TURP group and non-TURP group. Propensity score matching was performed for comorbidity, initial prostate-specific antigen (PSA), TNM stage, and Gleason score (GS). The Kaplan –Meier method was used to confirm castration-resistant prostate cancer (CRPC), cancer-specific surviv...
Source: Journal of Cancer Research and Clinical Oncology - February 7, 2018 Category: Cancer & Oncology Source Type: research

Exploratory analyses assessing the impact of early tumour shrinkage and depth of response on survival outcomes in patients with RAS wild-type metastatic colorectal cancer receiving treatment in three randomised panitumumab trials
ConclusionsThese exploratory analyses suggest that panitumumab is associated ETS and DpR benefits in patients withRAS WT mCRC and that achieving these endpoints during first-line treatment is linked with favourable outcomes. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 1, 2018 Category: Cancer & Oncology Source Type: research

The risk of lung cancer among cooking adults: a meta-analysis of 23 observational studies
ConclusionCooking oil fume is likely to be a risk factor for lung cancer for female, regardless of smoking status. Poor ventilation may increase the risk of lung cancer. Cooking methods may have different effect on lung cancer that deep frying may be healthier than stir frying. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 1, 2018 Category: Cancer & Oncology Source Type: research

Analysis of TSC1 mutation spectrum in mucosal melanoma
ConclusionsOur findings suggest thatTSC1 mutations are frequent in mucosal melanoma.TSC1 mutations can activate the mTOR pathway through phospho-S6RP and might be a poor prognostic predictor of mucosal melanoma. Our data implicate the potential significance ofTSC1 mutations for effective and specific drug therapy for mucosal melanoma. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 1, 2018 Category: Cancer & Oncology Source Type: research

The NF- κB signalling pathway in colorectal cancer: associations between dysregulated gene and miRNA expression
We examined differentially expressed genes in this pathway and miRNAs to determine associations with colorectal cancer (CRC).MethodsWe used data from 217 CRC cases to evaluate differences in NF- κB signalling pathway gene expression between paired carcinoma and normal mucosa and identify miRNAs that are associated with these genes. Gene expression data from RNA-Seq and miRNA expression data from Agilent Human miRNA Microarray V19.0 were analysed. We evaluated genes most strongly associated and differentially expressed (fold change (FC) of>  1.5 or
Source: Journal of Cancer Research and Clinical Oncology - February 1, 2018 Category: Cancer & Oncology Source Type: research

Induction of apoptosis in breast cancer cells in vitro by Fas ligand reverse signaling
ConclusionMembrane-bound FasL expression could be induced by IFN γ in a breast cancer cell model. More importantly, in the presence of IFNγ the Fas:Fc fusion protein was able to transmit pro-apoptotic signals to T47D and MCF7 cells, significantly inducing apoptosis. The current findings support further in vivo studies regarding FasL activation as a potential ta rget for therapeutic intervention in breast cancer. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 1, 2018 Category: Cancer & Oncology Source Type: research

Expression profile of microRNA-146a along HPV-induced multistep carcinogenesis: a study in HPV16 transgenic mice
ConclusionsThese results suggest that HPV16 induces the overexpression of miR-146a in the initial stages of carcinogenesis (hyperplasia and dysplasia), whereas decreases its expression at later stages (CIS). Taken together, these data implicate and suggest different roles of miR-146a in HPV-mediated carcinogenesis. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 1, 2018 Category: Cancer & Oncology Source Type: research

Presence of micropapillary and solid patterns are associated with nodal upstaging and unfavorable prognosis among patient with cT1N0M0 lung adenocarcinoma: a large-scale analysis
AbstractPurposeTo investigate whether the presence of micropapillary and solid patterns are associated with nodal upstaging and survival patterns in patients with cT1N0M0 lung adenocarcinoma.MethodWe retrospectively analyzed the clinicopathologic data of 2571 patients undergoing lobectomy and lymph node dissection or sampling. Logistic and Cox regression analysis were applied to determine the association between histological patterns and nodal upstaging and survival.ResultsNodal upstaging was detected in 115 patients (4.5%) through postoperative pathologic examination. Tumors absent of lepidic pattern, and present with aci...
Source: Journal of Cancer Research and Clinical Oncology - February 1, 2018 Category: Cancer & Oncology Source Type: research

Promising efficacy of novel BTK inhibitor AC0010 in mantle cell lymphoma
AbstractPurposeWe researched into the effect and mechanism of AC0010, a novel BTK inhibitor, in MCL, and compared its efficacy and safety with Ibrutinib to develop a preclinical study for the future therapy of MCL.MethodsMTS assay was used to detect the growth inhibition caused by AC0010 and Ibrutinib, respectively, in MCL cell lines (Jeko-1 and JVM-2), primary MCL cells, and normal peripheral lymphocytes. Apoptosis of Jeko-1 and JVM-2 after exposure into AC0010 and Ibrutinib was conducted by flow cytometry; the expression of apoptosis-related proteins was checked by Western blot. q-PCR and Western blot were applied to exa...
Source: Journal of Cancer Research and Clinical Oncology - February 1, 2018 Category: Cancer & Oncology Source Type: research

Patients ’ and hematologists’ concerns regarding tyrosine kinase-inhibitor therapy in chronic myeloid leukemia
AbstractPurposeTo explore patients ’ and hematologists’ concerns regarding tyrosine kinaseinhibitor (TKI)-therapy and identify variables associated these concerns. Methods A cross-sectional questionnaire including 16 common issues related to TKI-therapy was distributed to adults with chronic myeloid leukemia (CML) receiving TKIs and hematologists treating CML patients and answered anonymously.ResultsData from 1518 patient respondents receiving TKI-therapy  ≥ 3 months were analyzed. 939 (62%) were male. Median age was 42 years. 72% were receiving imatinib. Median TKI-therapy duration w...
Source: Journal of Cancer Research and Clinical Oncology - January 29, 2018 Category: Cancer & Oncology Source Type: research

Commentary on: Survival benefit of mantle cell lymphoma patients enrolled in clinical trials; a joint study from the LYSA group and French cancer registries
(Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 29, 2018 Category: Cancer & Oncology Source Type: research

Metal-free salan-type compound induces apoptosis and overcomes multidrug resistance in leukemic and lymphoma cells in vitro
ConclusionsTHG 1213 displays remarkable antitumor properties. In particular, the lack of metallic components of THG 1213 could prove to be beneficial in future clinical trials, as metal-containing drugs are known to show severe side effects. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 27, 2018 Category: Cancer & Oncology Source Type: research

SYK -targeted dendritic cell-mediated cytotoxic T lymphocytes enhance the effect of immunotherapy on retinoblastoma
ConclusionsOur data showed that SYK could be a potential immunotherapy target mediated by DCs. We propose SYK as a candidate target for treatment of chemoresistant RB. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 25, 2018 Category: Cancer & Oncology Source Type: research

Microarray profiles reveal that circular RNA hsa_circ_0007385 functions as an oncogene in non-small cell lung cancer tumorigenesis
This study aims to explore the expression profiles and pathological effects of circRNAs in non-small cell lung cancer (NSCLC).MethodsHuman circRNAs microarray analysis was performed to screen the expression profile of circRNAs in NSCLC tissue. Expressions of circRNA and miRNA in NSCLC tissues and cells were quantified by qRTPCR. Functional experiments were performed to investigate the biological functions of circRNA, including CCK-8 assay, colony formation assay, transwell assay and xenograft in vivo assay.ResultsHuman circRNAs microarray revealed a total 957 abnormally expressed circRNAs (>  twofold,P 
Source: Journal of Cancer Research and Clinical Oncology - January 25, 2018 Category: Cancer & Oncology Source Type: research

A comprehensive evaluation of clinicopathologic characteristics, molecular features and prognosis in lung adenocarcinoma with solid component
AbstractPurposeWe have reported that solid predominant lung adenocarcinoma according to the IASLC/ATS/ERS classification was associated with poor prognosis. However, the correlation of solid component with clinicopathological, molecular features, and prognosis in all lung adenocarcinoma patients remains unexplored.MethodsSurgically resected lung adenocarcinomas were divided into three groups, solid predominant (solid component accounting for at least 50%), solid minor (solid component accounting for 5 –45%) and solid negative. Patients’ clinicopathological characteristics, disease free survival (DFS), overall s...
Source: Journal of Cancer Research and Clinical Oncology - January 24, 2018 Category: Cancer & Oncology Source Type: research

Proliferation-associated miRNAs-494, -205, -21 and -126 detected by in situ hybridization: expression and prognostic potential in breast carcinoma patients
ConclusionsThe present paper reports for the first time on the prognostic value of miRNA-494 in invasive breast cancer. Particularly, detection of miRNA-494 could benefit patients with node-negative breast cancer in identifying subgroups with aggressive disease. Based on our experience, the developed automatic ISH method to visualize altered levels of miRNAs-494, -205, -21 and -126 could be applied to routine pathology diagnostics providing that conditions of tissue treatment, especially fixation delays, are managed. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 23, 2018 Category: Cancer & Oncology Source Type: research

Decision tree analysis to stratify risk of de novo non-melanoma skin cancer following liver transplantation
AbstractPurposeNon-melanoma skin cancer (NMSC) is the most common de novo malignancy in liver transplant (LT) recipients; it behaves more aggressively and it increases mortality. We used decision tree analysis to develop a tool to stratify and quantify risk of NMSC in LT recipients.MethodsWe performed Cox regression analysis to identify which predictive variables to enter into the decision tree analysis. Data were from the Organ Procurement Transplant Network (OPTN) STAR files of September 2016 (n = 102984).ResultsNMSC developed in 4556 of the 105984 recipients, a mean of 5.6  years after transplant. The...
Source: Journal of Cancer Research and Clinical Oncology - January 23, 2018 Category: Cancer & Oncology Source Type: research

Transforming growth factor beta 1 (TGF β1) polymorphisms and haplotype structures have dual roles in breast cancer pathogenesis
ConclusionThe present study indicates thatTGFB1 variants have subtype-specific roles in BC and may switch from tumor suppressor to promoter during tumor development, consistent with TGF β1 dual role in BC pathogenesis. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 23, 2018 Category: Cancer & Oncology Source Type: research

Clinical characteristics and outcomes of cancer patients requiring intensive care unit admission: a prospective study
AbstractPurposeThe study was aimed to describe the characteristics of cancer patients admitted to the oncological ICU and to identify clinical features associated with outcomes.MethodsThis is a prospective study (January 2014 to December 2015) of 522 cancer patients consecutively admitted to the oncological ICU. Patients with a length of oncological ICU stay  ≤ 1 day were excluded. Demographic and clinical variables were obtained at oncological ICU admission. The primary outcome of interest was hospital mortality. Logistic regression analysis was performed to identify independent risk factors for hosp...
Source: Journal of Cancer Research and Clinical Oncology - January 23, 2018 Category: Cancer & Oncology Source Type: research

Altered expression of HER-2 and the mismatch repair genes MLH1 and MSH2 predicts the outcome of T1 high-grade bladder cancer
ConclusionsAltered expression of the proto-oncogene HER-2 and the two molecular markers of genetic instability MLH1 and MSH2 predicted T1 high-grade BC outcome with the higher the number of altered markers the lower the DFS and PFS. These findings provide grounds for further testing them in predicting the outcome of this challenging disease. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 23, 2018 Category: Cancer & Oncology Source Type: research

The use of complementary and alternative medicine by patients in routine care and the risk of interactions
ConclusionThere was a risk of interactions between a biological CAM method and conventional drugs in 54.9% of the patients using CAM. To raise knowledge on interactions a better training for doctors with respect to CAM is strongly needed. Furthermore, patients ’ awareness should also be raised and communication between physician and patient on the topic improved. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 22, 2018 Category: Cancer & Oncology Source Type: research

Risk for cancer in living kidney donors and recipients
ConclusionsKidney transplantation was associated with an increased risk of cancer during a long-term follow-up. Long-term risk for cancer in LKDs and kidney recipients should be monitored. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 22, 2018 Category: Cancer & Oncology Source Type: research

Long non-coding RNA H19 promotes glucose metabolism and cell growth in malignant melanoma via miR-106a-5p/E2F3 axis
ConclusionsThis result elucidates a new mechanism for lncRNA H19 in melanoma development and provides a survival indicator and potential therapeutic target for melanoma patients. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 19, 2018 Category: Cancer & Oncology Source Type: research

Benefit of the addition of hormone therapy to neoadjuvant anthracycline-based chemotherapy for breast cancer: comparison of predicted and observed pCR
ConclusionTo the best of our knowledge, this is the first report investigating the efficacy of the combination of CT and HT in the neoadjuvant treatment of hormone receptor positive BC. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 17, 2018 Category: Cancer & Oncology Source Type: research

Analysis of prognostic factors after resection of solitary liver metastasis in colorectal cancer: a 22-year bicentre study
ConclusionThe long-term follow-up of patients with R0-resected liver metastasis is multifactorially influenced. Age and comorbidity have a role only in the overall survival. More than three lymph node metastasis reduced both the overall and disease-free survival. Extrahepatic tumour had a negative influence on the extrahepatic recurrence and on the overall survival. Neither overall survival nor recurrence rates was improved using neoadjuvant chemotherapy. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 16, 2018 Category: Cancer & Oncology Source Type: research

CTLA-4 polymorphisms: influence on transplant-related mortality and survival in children undergoing allogeneic hematopoietic stem cell transplantation
ConclusionThis study provides first evidence that the CTLA-4 polymorphisms are significant risk factors for TRM and survival in children undergoing allogeneic HSCT and should be evaluated in further trials. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 15, 2018 Category: Cancer & Oncology Source Type: research

Tumor expression of survivin, p53, cyclin D1, osteopontin and fibronectin in predicting the response to neo-adjuvant chemotherapy in children with advanced malignant peripheral nerve sheath tumor
ConclusionThe initial tumor tissue expression of OPN, survivin, p53 and cyclin D1 may serve as markers to predict response to naCHT in pediatric advanced MPNST. Future studies in more numerous group of patients are needed to confirm these preliminary results. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 13, 2018 Category: Cancer & Oncology Source Type: research

High nuclear MSK1 is associated with longer survival in breast cancer patients
AbstractPurposeMitogen- and stress-activated kinases (MSKs) are important substrates of the mitogen-activated protein kinase (MAPK)-activated protein kinase family. MSK1 and MSK2 are both nuclear serine/threonine protein kinases, with MSK1 being suggested to potentially play a role in breast cancer cell proliferation, cell cycle progression, cell migration, invasion and tumour growth. The aim of the current study was to assess MSK1 protein expression in breast cancer tumour specimens, evaluating its prognostic significance.MethodsA large cohort of 1902 early stage invasive breast cancer patients was used to explore the exp...
Source: Journal of Cancer Research and Clinical Oncology - January 11, 2018 Category: Cancer & Oncology Source Type: research

Antibody-based delivery of tumor necrosis factor (L19-TNF α) and interleukin-2 (L19-IL2) to tumor-associated blood vessels has potent immunological and anticancer activity in the syngeneic J558L BALB/c myeloma model
ConclusionIL2, TNF α, or IL2 plus TNFα (final 20 h) increased the proportion of CD4− CD25low effector lymphocytes possibly indicating immune activation. L19-TNFα/L19-IL2 combination therapy eradicated tumors in J558L myeloma BALB/c mice likely via TNFα-induced tumor necrosis and L19-TNFα/L19-IL2-mediated local cellular immune reactions. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 11, 2018 Category: Cancer & Oncology Source Type: research

MiR-29 silencing modulates the expression of target genes related to proliferation, apoptosis and methylation in Burkitt lymphoma cells
ConclusionsOur results suggest a significant role for miR-29s in BL pathogenesis in altering the expression of targets involved in critical cancer pathways, such as cell cycle control, apoptosis inhibition and DNA methylation. Moreover, methylation-mediated miR-29 epigenetic silencing may occur during BL development. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 9, 2018 Category: Cancer & Oncology Source Type: research

Transcriptional retargeting of herpes simplex virus for cell-specific replication to control cancer
ConclusionTranscriptional retargeting strategy holds great promise in retaining tumor specificity as well as full replication capacity of oncolytic virus in the target cell as urgently required by clinical trials. Future efforts should be aimed toward the development of multiple-component targeted oncolytic virus such as combing the transcriptional retargeting strategy and genetically attenuated modulation or post-transcriptional control that will be the most effective at generating truly tumor selective vectors. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 5, 2018 Category: Cancer & Oncology Source Type: research

Ecto-5 ′-nucleotidase/CD73 contributes to the radiosensitivity of T24 human bladder cancer cell line
ConclusionOur findings show that the induction of ecto-5 ′-nucleotidase/CD73 by radiation contributes to the radiosensitivity of T24 cell line. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 5, 2018 Category: Cancer & Oncology Source Type: research

Identification of specific feed-forward apoptosis mechanisms and associated higher survival rates for low grade glioma and lung squamous cell carcinoma
AbstractThe mechanisms of cell proliferation due to the overexpression of certain transcription factors (TFs) have been well documented in the cancer setting. However, many of these same TFs have pro-apoptotic effects, particularly when expressed or activated at high levels, a process referred to as feed-forward apoptosis (FFA). To determine whether cancers could be stratified on the basis of specific FFA signatures, RNASeq data representing samples from the cancer genome atlas were analyzed, revealing that high expression of the pro-proliferative TFs, MYC and YY1, is associated with a favorable outcome in low-grade glioma...
Source: Journal of Cancer Research and Clinical Oncology - January 5, 2018 Category: Cancer & Oncology Source Type: research

Influence of physical activity on the immune system in breast cancer patients during chemotherapy
ConclusionChemotherapy led to a decrease in nearly all measured immune cells. In this study, physical intervention with endurance or resistance training did not suppress cellular immunity any further. Larger multicenter trials are needed to evaluate the exact impact of sports intervention on immune cell subpopulations. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 5, 2018 Category: Cancer & Oncology Source Type: research

Risk factors for unplanned discontinuation of scheduled treatment in elderly patients with castration-resistant prostate cancer: results of the IBuTu study
AbstractPurposeTo gain knowledge about the factors associated with discontinuation of scheduled treatment in elderly men with castration-resistant prostate cancer (CRPC).MethodsPatients  ≥ 70 years with CRPC starting a new line of treatment were included in a prospective cohort study. A geriatric assessment (CGA) was performed at baseline, including comorbidity, mobility, functional/mental/nutritional status, as well as depression. Furthermore, pain intensity, quality of lif e, ECOG-performance status, and physicians’ and patients’ perception of health were documented. Reasons for and fact...
Source: Journal of Cancer Research and Clinical Oncology - January 4, 2018 Category: Cancer & Oncology Source Type: research

Elevated absolute NK cell counts in peripheral blood predict good prognosis in chronic lymphocytic leukemia
AbstractPurposeThe aim of this study was to investigate the prognostic significance of the absolute natural killer (NK) cell counts in peripheral blood in patients with chronic lymphocytic leukemia (CLL).MethodsA total of 273 previously untreated patients with CLL from April 2004 and October 2015 were enrolled into this retrospective study. We analysed the T cell subsets of all patients and figured out the number of NK cells. Comparisons of NK cell count as continuous parameter in different groups were described using Mann –Whitney U test and the Kruskal–Wallis test. Kaplan–Meier method was used to surviv...
Source: Journal of Cancer Research and Clinical Oncology - January 3, 2018 Category: Cancer & Oncology Source Type: research

A novel gene signature based on five glioblastoma stem-like cell relevant genes predicts the survival of primary glioblastoma
AbstractPurposePrimary glioblastoma (pGBM) is the most common and lethal type of neoplasms in the central nervous system, while the existing biomarkers, lacking consideration on the stemness changes of GBM cells, are not specific enough to predict the complex prognosis respectively. We aimed to build a high-efficiency prediction gene signature related to GBM cell stemness and investigate its prognostic value in primary glioblastoma.MethodsDifferentially expressed genes were screened in GSE23806 database. The selected genes were then verified by univariate Cox regression in 591 patients from four enormous independent databa...
Source: Journal of Cancer Research and Clinical Oncology - January 3, 2018 Category: Cancer & Oncology Source Type: research

Safety study and therapeutic drug monitoring of the oral tablet formulation of posaconazole in patients with haematological malignancies
This study aimed at evaluating the safety profile, the pharmacokinetic variability, and the concentration –toxicity relationship of posaconazole tablets in patients with haematological malignancies.MethodsSixty neutropenic patients treated with posaconazole tablets for prophylaxis of IFI were prospectively included in the study. Adverse drug reactions (ADR) were recorded and analyzed by the Regional Pharmacovigilance Centre to assess posaconazole implication. Blood samples were drawn once a week and plasma trough concentrations (Cmin) were assayed by LC –MS/MS. The rates of ADR by quartile ofCmin were compared....
Source: Journal of Cancer Research and Clinical Oncology - January 1, 2018 Category: Cancer & Oncology Source Type: research