Prognostic impact of rapid reduction of involved free light chains in multiple myeloma patients under first-line treatment with Bendamustine, Prednisone, and Bortezomib (BPV)
ConclusionThese results indicate that a rapid decrease in the iFLC on day 8 is an early prognostic marker for newly diagnosed MM pts undergoing BPV treatment. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 12, 2021 Category: Cancer & Oncology Source Type: research

Real-life comparison of the afatinib and first-generation tyrosine kinase inhibitors in nonsmall cell lung cancer harboring EGFR exon 19 deletion: a Turk Oncology Group (TOG) study
AbstractBackgroundThe new second-generation tyrosine kinase inhibitors (TKIs) have superior survival outcome and worse toxicity profile when compared with first-generation TKIs according to the results of clinical trials. However, there are limited studies that investigate the efficacy and safety of the new generation TKIs in real-world patients. Thus, we aimed to compare the efficacy and safety of the afatinib, an irreversible inhibitor of ErbB family receptor, and first-generation TKIs in real-world patients.Materials and methodsWe included advanced nonsmall cell lung cancer (NSCLC) patients who had EGFR exon 19del mutat...
Source: Journal of Cancer Research and Clinical Oncology - January 12, 2021 Category: Cancer & Oncology Source Type: research

Effects of a patient-tailored integrative oncology intervention in the relief of pain in palliative and supportive cancer care
ConclusionsHigh adherence to integrative care was found to be associated with a greater effect on pain relief at 6  weeks but not at 12 weeks in patients undergoing chemotherapy and/or palliative care. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 12, 2021 Category: Cancer & Oncology Source Type: research

Inflammatory bowel disease and risk of gastric, small bowel and colorectal cancer: a meta-analysis of 26 observational studies
ConclusionsIBD is mainly associated with increased risk of cancers in the lower gastrointestinal tract, including small bowel cancer and colorectal cancer. Because studies about the association between IBD and risk of gastric cancer and the populations in Asia are limited, more observational studies are required in the future. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 12, 2021 Category: Cancer & Oncology Source Type: research

Letter regarding, “Association between the use of aspirin and risk of lung cancer: results from pooled cohorts and Mendelian randomization analyses”
(Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 12, 2021 Category: Cancer & Oncology Source Type: research

Any progress in informed consenting for cancer treatment? Results from a cross sectional analysis at a comprehensive cancer center
ConclusionsTo ensure that informed consent is based on solid understanding, informed consenting must be patient-centered and consider the individual expectations, needs and abilities of cancer patients. Further studies are required to develop tailored informed consent strategies. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 9, 2021 Category: Cancer & Oncology Source Type: research

Surgical and oncological efficacy of laparoscopic-assisted total gastrectomy versus open total gastrectomy for gastric cancer by propensity score matching: a retrospective comparative study
ConclusionLATG appears to have comparable surgical and oncological safety with OTG by experienced surgeons. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 7, 2021 Category: Cancer & Oncology Source Type: research

Reviewer Acknowledgements 2020
(Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 7, 2021 Category: Cancer & Oncology Source Type: research

A note from the editors
(Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 7, 2021 Category: Cancer & Oncology Source Type: research

Management, functional outcomes and survival in a French multicentric series of 118 adult patients with cerebellar glioblastoma
AbstractPurposeTo analyze the outcomes and predictors in a large series of cerebellar glioblastomas in order to guide patient management.MethodsThe French brain tumor database and the Club de Neuro-Oncologie of the Soci été Française de Neurochirurgie retrospectively identified adult patients with cerebellar glioblastoma diagnosed between 2003 and 2017. Diagnosis was confirmed by a centralized neuropathological review.ResultsData from 118 cerebellar glioblastoma patients were analyzed (mean age 55.9  years, 55.1% males). The clinical presentation associated raised intracranial pressure (50.8%), st...
Source: Journal of Cancer Research and Clinical Oncology - January 5, 2021 Category: Cancer & Oncology Source Type: research

MRI-guided stereotactic radiation therapy for hepatocellular carcinoma: a feasible and safe innovative treatment approach
ConclusionMRgRT is a feasible and safe option showing favorable toxicity profile for HCC treatment. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 4, 2021 Category: Cancer & Oncology Source Type: research

Combination of CD47 and CD68 expression predicts survival in eastern-Asian patients with non-small cell lung cancer
AbstractObjectiveRecent studies have indicated that CD47, interacting with SIRP- α, conveys “don’t eat me” signal in evasion of tumor cells and serves as a potential target for cancer immunotherapy. The purpose of this study was to investigate the clinical correlation of CD47 and uncover prognostic implications of CD47 and CD68 in non-small cell lung cancer (NSCLC).MethodsThe specimens from 384 patients with completely resected NSCLC were collected for immunohistochemical assays of CD47 and CD68. Cox multivariate proportion hazard analyses were conducted to confirm the independent prognostic value o...
Source: Journal of Cancer Research and Clinical Oncology - January 4, 2021 Category: Cancer & Oncology Source Type: research

Genetic variants in NKG2D axis and susceptibility to Epstein –Barr virus-induced nasopharyngeal carcinoma
AbstractBackgroundNasopharyngeal carcinoma (NPC) is a rare epithelial carcinoma arising from the nasopharyngeal region. The pathogenesis of NPC is linked to Epstein –Barr virus (EBV) infection, although genetics and lifestyle factors appears to be also implicated. NKG2D is an immunoreceptor expressed by NK and T-cell subsets that recognizes MICA protein and other ligands on tumor cells. NKG2D interaction with MICA plays a role in the immunosurveillance to vir uses and cancer.MethodsWe investigated potential associations between functional polymorphisms inNKG2D andMICA genes with NPC susceptibility. We conducted a cas...
Source: Journal of Cancer Research and Clinical Oncology - January 3, 2021 Category: Cancer & Oncology Source Type: research

Significance of boost dose for  T4 nasopharyngeal carcinoma with residual primary lesion after intensity-modulated radiotherapy
AbstractBackgroundPrevious studies showed poorer survival in T4 disease with residual lesion. To evaluate the efficacy and toxicity of a boost dose for T4 nasopharyngeal carcinoma (NPC), patients with a residual primary lesion after intensity-modulated radiotherapy (IMRT).Methods398 T4 NPC patients with residual primary lesions after radical IMRT were retrospectively reviewed. An IMRT boost dose of 4 –6.75 Gy was delivered to the residual lesions in 2–3 fractions. Propensity score matching (PSM) was applied to balance potential confounders between groups (ratio, 1:2). The presence of Epstein–Barr vir...
Source: Journal of Cancer Research and Clinical Oncology - January 3, 2021 Category: Cancer & Oncology Source Type: research

Downregulation of lncRNA TSLNC8 promotes melanoma resistance to BRAF inhibitor PLX4720 through binding with PP1 α to re-activate MAPK signaling
ConclusionCollectively, our research provides a compelling rationale for resistance to BRAF inhibitor in melanoma, and the patient might benefit from the combinatorial therapy of BRAF inhibitors and lncRNA TSLNC8. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 3, 2021 Category: Cancer & Oncology Source Type: research

MAPK signaling pathway-targeted marine compounds in cancer therapy
ConclusionThe MAPK signaling pathway is a promising potential target for cancer therapy. Searching for marine compounds that exert anticancer effects by targeting the MAPK signaling pathway and developing them into new marine anticancer drugs will be beneficial for cancer treatment. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 3, 2021 Category: Cancer & Oncology Source Type: research

A new monoclonal antibody that blocks dimerisation and inhibits c-kit mutation-driven tumour growth
ConclusionsWe demonstratec-kit mutation-driven KIT auto-dimerisation prior to tyrosine kinase phosphorylation as same as the procedure in ligand-dependent signalling pathway and describe a monoclonal antibody, KITMAb, with strong affinity to the dimerisation domain of KIT that blocks the important step in both the KIT signalling pathways. Further, the results suggest that treatment with KITMAb may be potentially therapeutic in imatinib-resistant GIST. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 3, 2021 Category: Cancer & Oncology Source Type: research

Predicting positive peritoneal cytology in pancreatic cancer
ConclusionDiagnostic laparoscopy remains an important adjunct to the workup, diagnosis, and staging of pancreatic adenocarcinoma. Patients with locally advanced disease, significantly elevated serum Ca19-9 at diagnosis, and BMI  ≥ 25 kg/m2 may be at higher risk for positive peritoneal cytology, regardless of whether neoadjuvant therapy is administered. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 3, 2021 Category: Cancer & Oncology Source Type: research

Overexpressed CA12 has prognostic value in pancreatic cancer and promotes tumor cell apoptosis via NF- κB signaling
This study was, therefore, designed to assess the expression of CA12 in PAAD and to explore its underlying mechanistic role in this cancer type.MethodsImmunohistochemical staining was used to measure CA12 expression in PAAD samples. The functionality of pancreatic cancer cells expressing varying levels of CA12 was assessed through wound healing, Transwell, and CCK-8 assays. In addition, flow cytometry was used to measure apoptosis and cell cycle progression in these same cells, while Western blotting was used to analyze the expression of proteins associated with the NF- κB signaling pathway.ResultsPAAD tissue samples...
Source: Journal of Cancer Research and Clinical Oncology - January 2, 2021 Category: Cancer & Oncology Source Type: research

Kinase gene fusions: roles and therapeutic value in progressive and refractory papillary thyroid cancer
AbstractThe incidence of papillary thyroid cancer (PTC), the major type of thyroid cancer, is increasing rapidly around the world, and its pathogenesis is still unclear. There is poor prognosis for PTC involved in rapidly progressive tumors and resistance to radioiodine therapy. Kinase gene fusions have been discovered to be present in a wide variety of malignant tumors, and an increasing number of novel types have been detected in PTC, especially progressive tumors. As a tumor-driving event, kinase fusions are constitutively activated or overexpress their kinase function, conferring oncogenic potential, and their frequenc...
Source: Journal of Cancer Research and Clinical Oncology - January 2, 2021 Category: Cancer & Oncology Source Type: research

Identification of a novel therapeutic candidate, NRK, in primary cancer-associated fibroblasts of lung adenocarcinoma microenvironment
ConclusionHere, we first report that NRK is significantly elevated in LUAD-associated CAFs and may function as a promising therapeutic target for cancer combination treatment. Besides, modulation of ECM and glycolysis/gluconeogenesis pathways may be an efficient approach to alter CAFs functionality in LUAD. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 2, 2021 Category: Cancer & Oncology Source Type: research

Secondary esophageal squamous cell carcinoma after hematopoietic stem cell transplantation
ConclusionsIn this study, lesions were located in the cervical to upper thoracic esophagus in approximately 60% of all secondary ESCC cases after allo-HSCT. History of TBI and bone marrow transplantation are high risk of ESCC, and proactive screening endoscopy is desirable. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 2, 2021 Category: Cancer & Oncology Source Type: research

The role of clinical factors and immunocheckpoint molecules in the prognosis of patients with supratentorial extraventricular ependymoma: a single-center retrospective study
ConclusionPD-L1 expression was an independent and more readily obtained predictor of outcomes, representing a simple and reliable biological prognostic factor for patients with SEE. Further studies are needed to explore PD-L1 inhibitor treatment for patients with ependymoma.Clinical trial registrationNo clinical trials were performed in the study. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 2, 2021 Category: Cancer & Oncology Source Type: research

Vincristine upregulates PD-L1 and increases the efficacy of PD-L1 blockade therapy in diffuse large B-cell lymphoma
ConclusionsVCR upregulated PD-L1 expression in DLBCL cells partially by promoting the p-STAT3; VCR combined with PD-L1 Ab activated effector T cells and increased the antitumor immune response in vitro and in vivo. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 2, 2021 Category: Cancer & Oncology Source Type: research

Impact of STAT1 polymorphisms on crizotinib-induced hepatotoxicity in ALK-positive non-small cell lung cancer patients
ConclusionPolymorphism of rs10208033 is a potential biomarker for predicting crizotinib-induced hepatotoxicity. These results suggest thatSTAT1 plays an important role in crizotinib-induced hepatotoxicity. Further studies are needed to confirm our finding and understand the underlying mechanisms. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 2, 2021 Category: Cancer & Oncology Source Type: research

Take care or “German Angst”? Lessons from cancer care during COVID-19 pandemic in spring 2020
ConclusionsThe presented personal views and experiences allow focusing the discussions about heath care systems during the on-going pandemic. Support for health care workers, as much routine as possible in oncology services, and transparency in information will be the keys for good management in futural situations of crisis. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 2, 2021 Category: Cancer & Oncology Source Type: research

Clinical course and prognosis of patients with lung cancer who develop anticancer therapy-related pneumonitis
ConclusionAlthough patients who developed pneumonitis had relatively short survival times, the interval between initial therapy and pneumonitis had survival impact. Survival can be prolonged by administering further cancer treatment after resolution of pneumonitis. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 2, 2021 Category: Cancer & Oncology Source Type: research

Comparing hypofractionated and conventionally fractionated whole breast irradiation for patients with ductal carcinoma in situ after breast conservation: a propensity score-matched analysis from a national multicenter cohort (COBCG-02 study)
ConclusionA short course of radiation therapy seems to be comparable to CF-WBI in terms of clinical outcomes. These data support the use of hypofractionated schedules in DCIS patients, but considering the remaining uncertainties. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 2, 2021 Category: Cancer & Oncology Source Type: research

CircRNA-100284 activates aurora kinase B by inducing methylation of HSP70 via microRNA-217 to promote proliferation of bladder cancer cells
AbstractObjectiveThe malignant transformation of normal bladder cells (SV-HUC-1) was induced by arsenite to explore the possible mechanism of circRNA-100284 influencing bladder cancer cell proliferation.MethodsNormal bladder SV-HUC-1 cells were cultured with 2  μM arsenite to induce malignant transformation. After 0, 3, 6, 12, and 24 h of culture, the expression level of circRNA-100284 in cells was detected by quantitative real-time PCR. Western blotting assays were used to detect the expression levels of EZH2 and cyclin-D1 proteins in cells treated wi th different media. Cell cycle was analyzed by flow cytome...
Source: Journal of Cancer Research and Clinical Oncology - January 1, 2021 Category: Cancer & Oncology Source Type: research

Health services research in colorectal cancer: a quasi-experimental interventional pilot study on in- and outpatient oncology
ConclusionIn- and outpatient counseling in discharge and side effects management and nutrition improve the outcomes of colorectal cancer patients. Outpatient counseling should be further developed and evaluated in future studies. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 29, 2020 Category: Cancer & Oncology Source Type: research

Correction to: Results of  a randomized trial of treatment modalities in patients with low or early-intermediate risk prostate cancer (PREFERE trial)
The above mentioned corrections will not change the interpretation or conclusions. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 21, 2020 Category: Cancer & Oncology Source Type: research

Methadone-mediated sensitization of glioblastoma cells is drug and cell line dependent
ConclusionMET was found to be cytotoxic in GBM cells in vitro only at high, clinically not relevant concentrations, where it was effective in inducing apoptosis and necrosis. Sensitizing effects were only observed in combination with doxorubicin, but not with TMZ, and are dependent on cell line and the applied drug concentration. Therefore, our findings do not support the use of MET in the treatment of GBM in combination with TMZ, as no sensitizing effect of MET was observed. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 14, 2020 Category: Cancer & Oncology Source Type: research

Transcription factors CP2 and YY1 as prognostic markers in head and neck squamous cell carcinoma: analysis of The Cancer Genome Atlas and a second independent cohort
ConclusionOur data indicate that simultaneous expression ofYY1 andCP2 mRNA is associated with shorter overall survival. Thus, combined high mRNA expression might be a suitable prognostic marker for risk stratification in HNSCC patients. However, since we could not validate this finding at genomic or protein level, we hypothesize that unknown underlying mechanisms which regulate mRNA transcription of YY1 and CP2 are the actual culprits leading to a worse survival. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 14, 2020 Category: Cancer & Oncology Source Type: research

GATA binding protein 6 ( GATA6 ) is co-amplified with PIK3CA in patients with esophageal adenocarcinoma and is linked to neoadjuvant therapy
We examined a large number of EAC (n = 496) for theirGATA6 amplification by fluorescence in situ hybridization (FISH) analyzing both primary resected (n = 219) and neoadjuvant treated EAC (n = 277). Results were correlated to clinicopathological data and known mutations/amplifications in our EAC-cohort.ResultsGATA6 amplification was detectable in 49 (9.9%) EACs of our cohort. We observed an enrichment ofGATA6-positive tumors among patients after neoadjuvant treatment (12,3% amplified tumors versus 6,8% in the primary resected group;p = 0.044). Additionally, ...
Source: Journal of Cancer Research and Clinical Oncology - December 10, 2020 Category: Cancer & Oncology Source Type: research

Correction to: Major driver mutations are shared between sinonasal intestinal-type adenocarcinoma and the morphologically identical colorectal adenocarcinoma
In the original article, the reference Hwang et al. 2019 is incorrect. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 8, 2020 Category: Cancer & Oncology Source Type: research

Discrepancies between radiological and histological findings in preoperative core needle (CNB) and vacuum-assisted (VAB) breast biopsies
ConclusionDetermining imaging-pathology concordance after US-guided breast biopsy is essential. Discrepant cases and further diagnostic steps need to be discussed with an interdisciplinary approach. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 7, 2020 Category: Cancer & Oncology Source Type: research

Treatment patterns and clinical outcomes in patients with advanced non-small cell lung cancer initiating first-line treatment in the US community oncology setting: a real-world retrospective observational study
ConclusionThese results suggest that real-world outcomes in this community oncology setting improved with the introduction of immuno-oncology therapies. However, clinical benefits are limited in certain subgroups and tend to be reduced compared with clinical trial observations. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 2, 2020 Category: Cancer & Oncology Source Type: research

Deciphering the role of Wnt signaling in acute myeloid leukemia prognosis: how alterations in DNA methylation come into play in patients ’ prognosis
AbstractAcute myeloid leukemia (AML) is a malignant clonal disorder affecting myeloid differentiation through mechanisms that include epigenetic dysregulation. Abnormal changes in DNA methylation and gene expression profiles of pathways involved in hematopoietic development, such as Wnt/ β-catenin, contribute to the transformation, development, and maintenance of leukemic cells. This review summarizes the alterations of Wnt signaling-related genes at the epigenetic and transcriptional level and their implications for AML prognosis. Among the implications of epigenetic alterations i n AML, methylation of Wnt antagonist...
Source: Journal of Cancer Research and Clinical Oncology - November 20, 2020 Category: Cancer & Oncology Source Type: research

Implications of flavonoids as potential modulators of cancer neovascularity
AbstractPurposeThe formation of new blood vessels from previous ones, angiogenesis, is critical in tissue repair, expansion or remodeling in physiological processes and in various pathologies including cancer. Despite that, the development of anti-angiogenic drugs has great potential as the treatment of cancer faces many problems such as development of the resistance to treatment or an improperly selected therapy approach. An evaluation of predictive markers in personalized medicine could significantly improve treatment outcomes in many patients.MethodsThis comprehensive review emphasizes the anticancer potential of flavon...
Source: Journal of Cancer Research and Clinical Oncology - November 20, 2020 Category: Cancer & Oncology Source Type: research

Bispecific antibodies targeting dual tumor-associated antigens in cancer therapy
ConclusionsDual TAAs targeting BsAbs represent a valuable class of biologics and early stage clinical studies have demonstrated promising anti-tumor efficacy in both hematologic malignancies and solid tumors. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 20, 2020 Category: Cancer & Oncology Source Type: research

Patient expectations are better for immunotherapy than traditional chemotherapy for cancer
ConclusionsThe lack of understanding of ICIs should be improved by activities to increase the knowledge of ICI patients and the general population. In contrast to CT, ICIs invoked fewer negative associations with efficacy and toxicity. Therefore, attention should be paid to risk awareness when educating patients. (Clinical trial registration number: DRKS00011868)Trial Registration: German clinical trials register,www.germanctr.de, number DRKS00011868. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 20, 2020 Category: Cancer & Oncology Source Type: research

G protein-coupled estrogen receptor 1 (GPER-1) and agonist G-1 inhibit growth of ovarian cancer cells by activation of anti-tumoral transcriptome responses: impact of GPER-1 mRNA on survival
ConclusionsThe results of this study clearly support the hypothesis that GPER-1 acts as a tumor suppressor in ovarian cancer. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 20, 2020 Category: Cancer & Oncology Source Type: research

Preoperative prediction of perineural invasion and KRAS mutation in colon cancer using machine learning
ConclusionMachine learning models developed using preoperative CT data can predict PNI and KRAS mutation in colon cancer patients with satisfactory performance. Individual-stage models better-characterized the relationship between CT features and PNI or KRAS mutation than multi-stage models and demonstrated good prediction scores. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 20, 2020 Category: Cancer & Oncology Source Type: research

Clinical characteristics and comparison of the outcome in young versus older patients with upper gastrointestinal carcinoma
This study focuses on the investigation of the clinical characteristics and survival outcome of younger-age people with GET, when compared to older patients.MethodsPatients diagnosed with GET at the Medical University of Vienna between 2004 and 2016 were included in this study. Clinical parameters and the overall survival (OS) were compared between young ( ≤ 45 years) and elderly (≥ 65 years) patients.ResultsAmong 796 patients, who were eligible for this analysis, fifty-eight patients (7%) were  ≤ 45 years at the initial onset of the disease. These 58 young patients were ...
Source: Journal of Cancer Research and Clinical Oncology - November 20, 2020 Category: Cancer & Oncology Source Type: research

Robotic surgery versus open surgery for thyroid neoplasms: a systematic review and meta-analysis
ConclusionsRobotic surgery is a safe and feasible approach with remarkable superiority in reducing intraoperative damage and improving patients ’ quality of life compared to open surgery for thyroid neoplasms. Meanwhile, this procedure is also associated with long operative duration, insufficient removal of neck lymph nodes, which need to be given careful consideration. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 20, 2020 Category: Cancer & Oncology Source Type: research

Protein Kinase C Alpha (PKC α) overexpression leads to a better response to retinoid acid therapy through Retinoic Acid Receptor Beta (RARβ) activation in mammary cancer cells
ConclusionHere we propose that retinoids could lead a highly personalized anticancer treatment, bringing benefits to patients with aggressive breast tumors resulting from high PKC α expression but, an adequate expression of the RARβ receptor is required to ensure the effect on this process. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 20, 2020 Category: Cancer & Oncology Source Type: research

Ascitic Calprotectin as an early predictor of hepatocellular carcinoma in patients with cirrhotic ascites
ConclusionAscitic Calprotectin may offer an easy, affordable marker that can predict the early occurrence of HCC. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 20, 2020 Category: Cancer & Oncology Source Type: research

Hyperprogressive disease and its clinical impact in patients with recurrent and/or metastatic head and neck squamous cell carcinoma treated with immune-checkpoint inhibitors: Korean cancer study group HN 18 –12
This study examined the incidence, potential predictors, and clinical impact of HPD in R/M-HNSCC.MethodsWe retrospectively collected data of patients with R/M-HNSCC treated with ICIs between January 2013 and June 2018 from 11 medical centers in Korea. HPD was defined as tumor growth kinetics ratio (TGKr)  >  2, which was calculated by comparing TGK on ICIs with that before treatment with ICIs.ResultsOf 125 patients, 68 (54.4%) obtained progressive disease as their best responses (progressors). HPD was identified in 18 (26.5% of progressors, 14.4% of total) patients. Relatively younger age, primary tumor of...
Source: Journal of Cancer Research and Clinical Oncology - November 20, 2020 Category: Cancer & Oncology Source Type: research

First-line angiogenesis inhibitor plus erlotinib versus erlotinib alone for advanced non-small-cell lung cancer harboring an EGFR mutation
AbstractPurposeErlotinib is indicated as first-line treatment for patients with non-small-cell lung cancer (NSCLC) harboring an epidermal growth-factor –receptor (EGFR) mutation. Addition of a vascular endothelial growth factor (VEGF) inhibitor (anti-VEGF) in combination with the tyrosine-kinase inhibitor erlotinib in this setting is controversial.MethodsWe conducted a meta-analysis of randomized trials comparing anti-VEGF plus erlotinib vs erlotinib alone as first-line therapy for advanced NSCLC harboring anEGFR mutation. Outcomes included overall survival (OS), progression-free survival (PFS), objective response ra...
Source: Journal of Cancer Research and Clinical Oncology - November 20, 2020 Category: Cancer & Oncology Source Type: research

Sentinel lymph node intraoperative analysis in endometrial cancer
ConclusionThe intraoperative evaluation of SLN in endometrial cancer accurately identifies patients with macrometastases. This is the cohort that might benefit the most of a full lymphadenectomy for a higher risk of additional lymph node metastases. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 20, 2020 Category: Cancer & Oncology Source Type: research