Patient-derived, three-dimensional spheroid cultures provide a versatile translational model for the study of organ-confined prostate cancer
ConclusionsMulticellular 3D spheroids can be generated from patient-derived RP tissue samples and serve as an innovative in vitro model of organ-confined PCa. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 19, 2019 Category: Cancer & Oncology Source Type: research

Clinical impact of circulating LAPTM4B-35 in pancreatic ductal adenocarcinoma
AbstractPurposeLAPTM4B is upregulated in a wide range of cancers associated with poor prognosis. However, the clinical impact of LAPTM4B as diagnostic and prognostic marker in pancreatic ductal adenocarcinoma (PDAC) remains unknown. Thus, the aim of the present study was to investigate the expression of LAPTM4B as circulating marker in PDAC.MethodsExpression analysis of LAPTM4B-35 in pancreatic tissue and preoperative blood serum samples of 169 patients with PDAC UICC Stages I –IV (n = 98), chronic pancreatitis (n = 41), and healthy controls (n = 30) by immunohistochemistry, ...
Source: Journal of Cancer Research and Clinical Oncology - February 18, 2019 Category: Cancer & Oncology Source Type: research

CD24 targeting bi-specific antibody that simultaneously stimulates NKG2D enhances the efficacy of cancer immunotherapy
ConclusionNK cells play a major role in the natural, innate immune system, and they have the function of identifying and killing target cells. cG7-MICA remodels the function of MICA molecules to activate NK cells, which provides a possible strategy for HCC-targeting immunotherapy. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 18, 2019 Category: Cancer & Oncology Source Type: research

CD110 promotes pancreatic cancer progression and its expression is correlated with poor prognosis
ConclusionsCD110 promotes pancreatic cancer progression and it may serve as a predictive factor for liver metastasis. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 15, 2019 Category: Cancer & Oncology Source Type: research

Preoperative controlling nutritional status (CONUT) score as a novel immune-nutritional predictor of survival in non-metastatic clear cell renal cell carcinoma of ≤ 7 cm on preoperative imaging
This study aimed at investigating the prognostic value of Preoperative controlling nutritional status (CONUT) score in non-metastatic clear-cell renal cell carcinoma of ≤ 7 cm on preoperative imaging.MethodsWe retrospectively included 1046 among 1637 patients who underwent radical or partial nephrectomy for solid renal masses ≤ 7 cm (2005–2014) after excluding other pathology, conditions affecting CONUT score components, metastasis, regional lymphadenopathy, positive margin, and follow-up
Source: Journal of Cancer Research and Clinical Oncology - February 13, 2019 Category: Cancer & Oncology Source Type: research

Prevalence and clinical significance of RBM3 immunostaining in non-small cell lung cancers
ConclusionsIn summary, our study shows that loss of RBM3 expression predicts worse clinical outcome in LUAC patients. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 13, 2019 Category: Cancer & Oncology Source Type: research

Does FDG PET/CT have a role in determining adjuvant chemotherapy in surgical margin-negative stage IA non-small cell lung cancer patients?
AbstractPurposeTo evaluate the prognostic value of FDG PET/CT metabolic parameter compared to clinico –pathological risk factors in surgical margin-negative stage IA non-small cell lung cancer (NSCLC) patients.Methods167 patients with consecutive FDG PET/CT scans from 2009 to 2015 performed for staging of NSCLC stage IA with plans for curative surgery were retrospectively reviewed. Maximum standardized uptake value (SUVmax) of primary tumor and mean SUV of liver were acquired from PET/CT. Tumor-to-liver SUV ratio (TLR) was calculated. Charts were reviewed to obtain basic patient characteristics (age, sex, smoking his...
Source: Journal of Cancer Research and Clinical Oncology - February 13, 2019 Category: Cancer & Oncology Source Type: research

Cancer risk in stroke survivors followed for up to 10  years in general practices in Germany
AbstractAimsThe goal of this study was to analyze cancer risk in stroke survivors followed for up to 10  years in general practices in Germany.MethodsThe current study sample included patients who received an initial stroke diagnosis in one of 1262 general practices in Germany between 2006 and 2015 (index date). Patients without stroke were matched (1:1) to patients with stroke by age, gender, index year, and 16 comorbidities diagnosed in the 12  months prior to the index date using a propensity score method. The main outcome of the study was the risk of cancer as a function of stroke within 10 years of the ...
Source: Journal of Cancer Research and Clinical Oncology - February 9, 2019 Category: Cancer & Oncology Source Type: research

Expression of Syk and MAP4 proteins in ovarian cancer
AbstractPurposeWe have previously reported on the prognostic importance of the calpain family of proteins in ovarian cancer, especially calpain-2. Spleen tyrosine kinase (Syk) phosphorylates a variety of cytoskeletal proteins with studies suggesting potential interactions between Syk and conventional calpains. Microtubule-associated protein 4 (MAP4) has been reported to be regulated by Syk.MethodsThe current study assessed Syk and MAP4 protein expression, by immunohistochemistry on a tissue microarray comprised of cores from primary ovarian carcinomas (n = 575), to evaluate associations with patient clinical ...
Source: Journal of Cancer Research and Clinical Oncology - February 8, 2019 Category: Cancer & Oncology Source Type: research

Radiomics-based machine learning methods for isocitrate dehydrogenase genotype prediction of diffuse gliomas
ConclusionsRF is a promising machine learning method in predicting IDH genotype. Development of an accurate and reliable model can assist in the initial diagnostic evaluation and treatment planning for diffuse glioma patients. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 4, 2019 Category: Cancer & Oncology Source Type: research

Pre-treatment serum levels of soluble programmed cell death-ligand 1 predict prognosis in patients with hepatitis B-related hepatocellular carcinoma
AbstractPurposeAnti-programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) therapy has shown promise in tumor immunotherapy. Our objectives were to measure pre-treatment serum-soluble PD-L1 (sPD-L1) levels and to assess the relationships between sPD-L1 levels and clinical characteristics, prognosis, and tumor tissue PD-L1 expression in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).MethodsPre-treatment serum sPD-L1 levels were measured with an enzyme-linked immunosorbent assay (ELISA) in 81 patients with HBV-related HCC and compared to those in 49 healthy controls. The associati...
Source: Journal of Cancer Research and Clinical Oncology - February 1, 2019 Category: Cancer & Oncology Source Type: research

Should patients with stage IB non-small cell lung cancer receive adjuvant chemotherapy? A comparison of survival between the 8th and 7th editions of the AJCC TNM staging system for stage IB patients
AbstractIntroductionThe aims of this study were to compare the efficacy of platinum-based adjuvant chemotherapy in resected patients with stage IB NSCLC according to the 7th and 8th editions of the American Joint Committee on Cancer (AJCC) staging manuals on tumor, node, and metastasis (TNM) staging systems, respectively.MethodsThis retrospective analysis included 569 patients who underwent pulmonary resection for primary non-small cell lung cancer. 5-year overall survival (OS) was compared in stage IB disease using the 8th and 7th editions of the TNM classification, respectively. Survival curves were plotted using the Kap...
Source: Journal of Cancer Research and Clinical Oncology - February 1, 2019 Category: Cancer & Oncology Source Type: research

Spatiotemporal characteristics of fibroblasts-dependent cancer cell invasion
ConclusionOur current study clearly showed that fibroblast-dependent cancer cell invasion was characterized by the progression in cell cycle and formation of small cancer cell nests. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 1, 2019 Category: Cancer & Oncology Source Type: research

Histone deacetylase inhibitor ITF2357 (givinostat) reverts transformed phenotype and counteracts stemness in in vitro and in vivo models of human glioblastoma
ConclusionsThe present findings provide evidence of the key role played by HDACs in sustaining transformed and stem phenotype of GBM and strongly suggest that ITF2357 may have a clinical potential for the HDACi-based therapeutic strategies against GBM. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 1, 2019 Category: Cancer & Oncology Source Type: research

Induced expression of GINS complex is an essential step for reactivation of quiescent stem-like tumor cells within the peri-necrotic niche in human glioblastoma
ConclusionsThese findings indicate the essential role of GINS complex in the switch between quiescence and proliferation of tumor cells inside and outside the peri-necrotic niche. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - February 1, 2019 Category: Cancer & Oncology Source Type: research

Serum miR-16 as a potential biomarker for human cancer diagnosis: results from a large-scale population
AbstractBackgroundCancer is a serious public health problem worldwide, and difficulty in early diagnosis has been the chief obstacle to improve the prognosis of patients. Recently, microRNAs (miRNAs) were widely studied to be potential biomarkers for cancer detection. miR-16 is a prevalent but sophisticated one. In the current study, we aimed to assess the diagnostic value of serum miR-16 for cancer detection.MethodsA total of 1458 cancer patients, containing ten types of cancers, and 1457 non-cancer controls were recruited in this study. qRT-PCR was used for the amplification of miRNAs. In addition, a meta-analysis of rep...
Source: Journal of Cancer Research and Clinical Oncology - January 31, 2019 Category: Cancer & Oncology Source Type: research

NRF2 orchestrates the redox regulation induced by radiation therapy, sustaining embryonal and alveolar rhabdomyosarcoma cells radioresistance
ConclusionsTaken together, our data suggest the strategic role of oxidant/antioxidant balance in restraining the therapeutic efficiency of RT in RMS treatment and identify NRF2 as a new potential molecular target whose inhibition might represent a novel radiosensitizing therapeutic strategy for RMS clinical management. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 30, 2019 Category: Cancer & Oncology Source Type: research

Mistletoe in oncological treatment: a systematic review
ConclusionsWith respect to quality of life or reduction of treatment-associated side effects, a thorough review of the literature does not provide any indication to prescribe mistletoe to patients with cancer. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 23, 2019 Category: Cancer & Oncology Source Type: research

Comparative analysis of co-occurring mutations of specific tumor suppressor genes in lung adenocarcinoma between Asian and Caucasian populations
AbstractIntroductionMutated tumor suppressor genes (TSG) such asTP53, STK11, andMGA are widely-reported. We hypothesized the presence of single mutation or co-occurring mutations in these specific genes may represent a significant therapeutic target for lung adenocarcinoma.MethodsWe sequenced lung adenocarcinoma samples from 677 East-Asian patients, combined them with those from cBioPortal public database (including TCGA) and performed a comparative analysis between Asian and Caucasian populations.ResultsEast-Asian lung adenocarcinomas presented distinct driver-mutational distribution compared to that of Caucasians (79% vs 56%,p 
Source: Journal of Cancer Research and Clinical Oncology - January 23, 2019 Category: Cancer & Oncology Source Type: research

Mistletoe in oncological treatment: a systematic review
ConclusionsWith respect to survival, a thorough review of the literature does not provide any indication to prescribe mistletoe to patients with cancer. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 23, 2019 Category: Cancer & Oncology Source Type: research

Combining immunotherapy and natural immune stimulants: mechanisms and clinical implications
(Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 23, 2019 Category: Cancer & Oncology Source Type: research

ePROs in the follow-up of cancer patients treated with immune checkpoint inhibitors: a retrospective study
ConclusionsThe results of the current study suggest that real-world symptom data collected through the ePRO application on cancer patients receiving ICI therapy aligns with the data from clinical trials. Correlations between different symptoms occur, which might reflect therapeutic efficiency, side effects, or tumor progression. These correlations should be further investigated with data coupled to clinical outcomes. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 21, 2019 Category: Cancer & Oncology Source Type: research

GLRX inhibition enhances the effects of geftinib in EGFR-TKI-resistant NSCLC cells through FoxM1 signaling pathway
ConclusionsOur results suggest that GLRX inhibition enhances the effects of geftinib in EGFR-TKI-resistant NSCLC cells. Thus, GLRX may represent a therapeutic target for increasing the efficiency of gefitinib treatment. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 19, 2019 Category: Cancer & Oncology Source Type: research

Expression of cancer –testis antigens in esophageal cancer and their progress in immunotherapy
ConclusionIn this review, we summarize expression and prognostic value of MAGE-A, NY-ESO-1, LAGE-1, and TTK in esophageal cancer and point out recent advances in immunotherapy about them. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 17, 2019 Category: Cancer & Oncology Source Type: research

Effects of metabolic syndrome on the prevalence of prostate cancer: historical cohort study using the national health insurance service database
ConclusionMetS and its components, especially decreased HDL-cholesterol levels and central obesity, were related to the increased prevalence of prostate cancer. Preventing MetS, maintaining high HDL-cholesterol level, and maintaining low waist circumference might be useful ways for decreasing the prevalence of prostate cancer. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 17, 2019 Category: Cancer & Oncology Source Type: research

ZWINT is the next potential target for lung cancer therapy
AbstractPurposeWe aimed to analyze the expression of ZWINT, NUSAP1, DLGAP5, and PRC1 in tumor tissues and adjacent tissues with public data.MethodsThe expression patterns of four genes were detected in cancer tissues and adjacent tissues by qRT-PCR. The overall survival analysis was used to explore these genes in lung adenocarcinoma and squamous cell carcinoma patients. Knockdown assays were used to select the most suitable gene among these four genes. Cell function assays with the knockdown gene were conducted in A549 and NCL H226 cells. The role of the knockdown gene in lung cancer was dissected in a mice tumor model. Tr...
Source: Journal of Cancer Research and Clinical Oncology - January 14, 2019 Category: Cancer & Oncology Source Type: research

Pre-orchiectomy tumor marker levels should not be used for International Germ Cell Consensus Classification (IGCCCG) risk group assignment
AbstractPurposeTo investigate whether the use of pre-orchiectomy instead of pre-chemotherapy tumor marker (TM) levels has an impact on the International Germ Cell Consensus Classification (IGCCCG) risk group assignment in patients with metastatic germ cell tumors (GCT).MethodsDemographic and clinical information of all patients treated for primary metastatic testicular non-seminomatous GCT in our tertiary care academic center were extracted from medical charts. IGCCCG risk group assignment was correctly performed with pre-chemotherapy marker levels and additionally with pre-orchiectomy marker levels. Agreement between pre-...
Source: Journal of Cancer Research and Clinical Oncology - January 14, 2019 Category: Cancer & Oncology Source Type: research

Pathobiological role of cleft palate transmembrane protein 1 family proteins in oral squamous cell carcinoma
AbstractPurposeCleft palate transmembrane protein 1 (Clptm1) and its paralog protein, Cisplatin resistance-related protein 9 (CRR9) constitute a highly conserved protein family, fromCaenorhabditis elegans toHomo sapiens. In the present study, we examined the clinicopathological and biological significance of Clptm1 and CRR9 expression in oral squamous cell carcinoma (OSCC).MethodsNinety-eight OSCC tissue specimens were immunohistochemically stained with specific antibodies to Clptm1 and CRR9. The immunoreactivity of Clptm1 and CRR9 was then correlated with clinicopathological factors, including the prognosis of patients. s...
Source: Journal of Cancer Research and Clinical Oncology - January 11, 2019 Category: Cancer & Oncology Source Type: research

The anticancer effects and mechanisms of fucoxanthin combined with other drugs
ConclusionFx combined with other drugs has significant anticancer effects by various mechanisms and could be a potential therapeutic strategy for different types of cancer. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 9, 2019 Category: Cancer & Oncology Source Type: research

Immune checkpoint blockade for Merkel cell carcinoma: actual findings and unanswered questions
ConclusionThe therapeutic landscape of MCC is rapidly evolving: many open issues will probably be resolved, and many other questions are likely to arise in the next few years. The results of ongoing prospective clinical trials and of several other studies on these issues are eagerly awaited. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 7, 2019 Category: Cancer & Oncology Source Type: research

High frequency of H3 K27M mutations in adult midline gliomas
ConclusionH3 K27M mutations are frequent in adult midline gliomas and have a prognostic role similar to H3 K27M wild-type high-grade tumors. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 4, 2019 Category: Cancer & Oncology Source Type: research

Computer-assisted medical image classification for early diagnosis of oral cancer employing deep learning algorithm
ConclusionsWe compared the obtained results from another traditional medical image classification algorithm. From the obtained result, we identify that the quality of diagnosis is increased by proposed regression-based partitioned CNN learning algorithm for a complex medical image of oral cancer diagnosis. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 3, 2019 Category: Cancer & Oncology Source Type: research

FTIR-based spectrum of salivary exosomes coupled with computational-aided discriminating analysis in the diagnosis of oral cancer
ConclusionWe showed the specific IR spectral signature for OC salivary exosomes, which was accurately differentiated from HI exosomes based on detecting subtle changes in the conformations of proteins, lipids and nucleic acids using optimized artificial neural networks with small data sets. This non-invasive method should be further investigated for diagnosis of oral cancer at its very early stages or in oral lesions with potential for malignant transformation. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 3, 2019 Category: Cancer & Oncology Source Type: research

Prognostic value of initial bone marrow disease detection by multiparameter flow cytometry in children with neuroblastoma
AbstractPurposeMulticolor flow cytometry (MFC) is widely available, fast and has an easy-to perform approach for finding neuroblastoma (NB) cells among normal bone marrow (BM) hematopoietic cells. Aim of the study was to investigate prognostic significance of initial MFC tumor cells ’ detection in BM of children with NB.Methods51 patients (24 boys and 27 girls) aged from 6  days to 15 years (median age 1 year 3 months) with NB were included in the study. BM samples at the time of diagnosis were obtained from 2 to 5 aspiration sites per patient. CD45(−)CD56(+)CD81(+)GD2(+)-cells were evaluate...
Source: Journal of Cancer Research and Clinical Oncology - January 2, 2019 Category: Cancer & Oncology Source Type: research

A three-gene methylation marker panel for the nodal metastatic risk assessment of muscle-invasive bladder cancer
In this study, we aimed to identify a DNA methylation pattern suitable for prognosis assessment of muscle-invasive bladder cancer and to investigate metastasis-associated processes regulated by DNA methylation.MethodsGenome-wide methylation analysis was performed on 23 muscle-invasive bladder tumors by microarray analysis. Validation was performed by the qAMP technique in two different patient cohorts (n = 32 andn = 100). mRNA expression was analyzed in 12 samples. Protein expression was determined using tissue microarrays of 291 patients. Bladder cancer cell lines T24 and 253JB-V were used for ...
Source: Journal of Cancer Research and Clinical Oncology - January 2, 2019 Category: Cancer & Oncology Source Type: research

Differential molecular pathways expression in HER2 positive early breast cancer according to hormone receptor status
ConclusionsAccording to HR status, HER2  + tumors express different pathways profiles: the overexpression of PI3K, MAPK and NOTCH pathways in HER2+/HR− group could justify different survival outcomes and treatment sensitivity. The identification of tumor driver pathways may be a useful instrument for individualized pathway-directed therapies. Further clinical implications are warranted. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 2, 2019 Category: Cancer & Oncology Source Type: research

Impact of the homogeneous and heterogeneous risk factors on the incidence and survival outcome of bone metastasis in NSCLC patients
ConclusionsThe homogeneous and heterogeneous risk factors for morbidity and survival outcome of BM patients could help physicians in more precise and individualized screening and therapies for BM patients in NSCLC. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 2, 2019 Category: Cancer & Oncology Source Type: research

FDG PET/CT to predict the curability of endoscopic resection for early gastric cancer
ConclusionFDG PET/CT may be a useful complementary imaging modality to endoscopy to predict the curability of ESD for EGC. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 2, 2019 Category: Cancer & Oncology Source Type: research

Identification of myeloid-derived suppressor cells that have an immunosuppressive function in NF2 patients
ConclusionsHLA-DR−CD33+CD11b+ cells may represent a population of MDSCs in NF2 patients. Dissecting the mechanisms behind these suppressive mechanisms will be helpful for the design of effective immunotherapeutic protocols and likely provide a new effective treatment for NF2 patients. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 2, 2019 Category: Cancer & Oncology Source Type: research

A novel histologic grading system based on lymphovascular invasion, perineural invasion, and tumor budding in colorectal cancer
This study aimed to evaluate the prognostic significance of lymphovascular (LVI), perineural invasion (PNI), and tumor budding positivity in patients with colorectal cancer.MethodsFrom January 2008 to December 2011, 3707 consecutive patients who underwent curative surgery for stage I –III colorectal cancer were assessed. These patients were then categorized into four groups based on LVI, PNI, and tumor budding (risk grouping): all negative (n = 1495), 1 + only (n = 1063), 2 + only (n = 861), and all positive (n = 288).ResultsWith a me...
Source: Journal of Cancer Research and Clinical Oncology - January 2, 2019 Category: Cancer & Oncology Source Type: research

Prognostic relevance of low-grade versus high-grade FIGO IB1 squamous cell uterine cervical carcinomas
ConclusionA binary grading model for the conventional tumor grade (based on the degree of keratinization) in SCC of the uterine cervix may allow a better prognostic discrimination than the traditionally used three-tiered system. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 2, 2019 Category: Cancer & Oncology Source Type: research

Advanced adenoid cystic carcinoma (ACC) is featured by SWI/SNF chromatin remodeling complex aberrations
ConclusionsOur study indicated that ACC features aberrant expression of genes controlling chromatin status and structure. We found that the balance between SWI/SNF classes is moved towards the BRM ATPase-containing complex in ACC. As BRM is known to be involved in chemoresistance in cancer cells, this observation may be the likely explanation for ACC chemoresistance. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 1, 2019 Category: Cancer & Oncology Source Type: research

Novel therapeutic compound acridine –retrotuftsin action on biological forms of melanoma and neuroblastoma
ConclusionOur data show that the biological forms of certain tumors responded in different ways to the action of ART. As a combination of retrotuftsin and acridine, the compound can be an inducer of apoptotic cell death of melanoma, especially the amelanotic form. Although the mechanism of the interrelationships between energy metabolism and cell death is not fully understood, interference of ART with TAC enzymes could encourage the further investigation of its anticancer action. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 1, 2019 Category: Cancer & Oncology Source Type: research

Feasibility and safety of nivolumab in advanced hepatocellular carcinoma: real-life experience from three German centers
DiscussionNivolumab treatment seems safe and clinical efficacious. Patients with advanced liver disease require further prospective evaluation due to probable limited efficacy of nivolumab. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 1, 2019 Category: Cancer & Oncology Source Type: research

LncRNA GAS5 regulates redox balance and dysregulates the cell cycle and apoptosis in malignant melanoma cells
AbstractPurposeClinical outcomes for advanced malignant melanoma (MM) are often poor due to tumor invasiveness, metastasis, recurrence, and multidrug resistance.MethodsWe investigated whether apoptosis, cell cycle regulation, oxidative status, and redox balance were altered by changes in the expression of the long noncoding RNA, growth arrest-specific transcript 5 (GAS5), in MM cells.ResultsAnalysis of clinical samples from MM patients showed that the rate of reduced GAS5 expression, relative to that in adjacent noncancerous tissues, was significantly lower for tumors from patients with advanced disease (76.6%,P 
Source: Journal of Cancer Research and Clinical Oncology - December 19, 2018 Category: Cancer & Oncology Source Type: research

Identification of genes and pathways, including the CXCL2 axis, altered by DNA methylation in hepatocellular carcinoma
AbstractPurposeRecent genetic studies have suggested that tumor suppressor genes are often silenced during carcinogenesis via epigenetic modification caused by methylation of promoter CpG islands. Here, we characterized genes inactivated by DNA methylation in human hepatocellular carcinoma (HCC) to identify the genes and pathways involved in DNA methylation in hepatocellular carcinoma.MethodsEight HCC-derived cell lines were treated with a DNA demethylating agent, 5-aza-2 ′-deoxycytidine. Additionally, 100 pairs of primary HCC and adjacent non-cancerous tissues as well as 15 normal liver tissues were analyzed by comp...
Source: Journal of Cancer Research and Clinical Oncology - December 18, 2018 Category: Cancer & Oncology Source Type: research

Fecal volatile organic compounds for early detection of colorectal cancer: where are we now?
ConclusionBased on the included studies, fecal VOC analyses seem promising for future screening of CRC and AA, with potentially improved test performances allowing for earlier detection of AA and CRC and consequently earlier initiation of treatment, possibly reducing morbidity and mortality rates next to lower rates of (unnecessary) colonoscopies. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 15, 2018 Category: Cancer & Oncology Source Type: research

Melanoma tumour vasculature heterogeneity: from mice models to human
AbstractTumour angiogenesis is defined by an anarchic vasculature and irregularities in alignment of endothelial cells. These structural abnormalities could explain the variability in distribution of nanomedicines in various tumour models. Then, the main goal of this study was to compare and to characterize the tumour vascular structure in different mouse models of melanoma tumours (B16F10 and SK-Mel-28) and in human melanomas from different patients. Tumours were obtained by subcutaneous injection of 106 B16F10 and 3.106 SK-Mel-28 melanoma cells in C57BL/6 and nude mice, respectively. Tumour growth was evaluated weekly, w...
Source: Journal of Cancer Research and Clinical Oncology - December 13, 2018 Category: Cancer & Oncology Source Type: research

Increasing trends in in situ breast cancer incidence in a region with no population-based mammographic screening program: results from Zurich, Switzerland 2003 –2014
AbstractPurposeIncrease in in situ breast cancer (BCIS) incidence has been reported across Europe and the USA. However, little is known about the trends in BCIS incidence in regions without population-based mammographic screening programs. We set out to investigate these trends in Zurich, Switzerland, where only opportunistic mammographic screening exists.MethodsData from 989 women diagnosed with a primary BCIS between 2003 and 2014 were used in our analyses. Age-standardized incidence rates per 100,000 person-years (ASR) were computed per year. Additional analyses by BCIS subtype, by age group at diagnosis and by incidenc...
Source: Journal of Cancer Research and Clinical Oncology - December 13, 2018 Category: Cancer & Oncology Source Type: research

Chinese guidelines for the diagnosis and comprehensive treatment of colorectal liver metastases (version 2018)
AbstractThe liver is the most common anatomical site for hematogenous metastases of colorectal cancer, and colorectal liver metastases is one of the most difficult and challenging points in the treatment of colorectal cancer. To improve the diagnosis and comprehensive treatment in China, the Guidelines have been edited and revised several times since 2008, including the overall evaluation, personalized treatment goals and comprehensive treatments, to prevent the occurrence of liver metastases, improve the resection rate of liver metastases and survival. The revised Guideline includes the diagnosis and follow-up, prevention...
Source: Journal of Cancer Research and Clinical Oncology - December 12, 2018 Category: Cancer & Oncology Source Type: research