Personalizing vulvar cancer workflow in COVID-19 era: a proposal from Vul.Can MDT
ConclusionWe suggest that our proposals are applicable in this setting of patients, considering anyway current international recommendations and guidelines. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - September 3, 2020 Category: Cancer & Oncology Source Type: research

Correlations between circulating tumor cell phenotyping and 18F-fluorodeoxyglucose positron emission tomography uptake in non-small cell lung cancer
AbstractPurposeThe epithelial-to-mesenchymal transition (EMT) phenotype-based subsets of circulating tumor cells (CTCs) might be predictors of tumor progression. We evaluated the clinical properties of different phenotypic CTCs in patients with non-small cell lung cancer (NSCLC). Secondly, we explored the association between different phenotypic CTCs and the uptake of 18F-fluorodeoxyglucose (FDG) by the primary tumor on a positron emission tomographic (PET) scan.MethodsVenous blood samples from 34 pathologically confirmed Stage IIB-IVB NSCLC patients were collected prospectively. CTCs were immunoassayed using a SE-i &middo...
Source: Journal of Cancer Research and Clinical Oncology - September 3, 2020 Category: Cancer & Oncology Source Type: research

Oral cancer awareness campaign in Northern Germany: first positive trends in incidence and tumour stages
ConclusionA slight trend towards a temporary increase in incidence rates, especially among women, was observed. From an epidemiological point of view, this might indicate the initial success of this campaign. The slight trend in favour of stage I tumours could be seen as an initial minor success in terms of the early detection of oral cancer. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - September 3, 2020 Category: Cancer & Oncology Source Type: research

A randomized, double-blind, placebo controlled, phase II study to evaluate the efficacy of ginseng in reducing fatigue in patients treated for head and neck cancer
ConclusionThe present data shows that American ginseng has insufficient evidence to be recommended for Cancer Related Fatigue (CRF) in post treatment HNC survivors. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - September 3, 2020 Category: Cancer & Oncology Source Type: research

Potential of platinum-resensitization by Wnt signaling modulators as treatment approach for epithelial ovarian cancer
ConclusionAccording to the described effects on EOC biology, all three Wnt manipulators seem to have the potential to augment the impact of a platinum-based chemotherapy in EOC. This is promising as a dominance of this pathway was confirmed in serous histology. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - September 3, 2020 Category: Cancer & Oncology Source Type: research

Aberrant DNA methylation results in altered gene expression in non-alcoholic steatohepatitis-related hepatocellular carcinomas
ConclusionDNA methylation alterations may occur under the necroinflammatory conditions characteristic of NASH and participate in NASH-related hepatocarcinogenesis through aberrant expression of tumor-related genes. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - September 3, 2020 Category: Cancer & Oncology Source Type: research

The prognostic value of leucine-rich repeat-containing G-protein (Lgr5) and its impact on clinicopathological features of colorectal cancer
ConclusionOur results suggest a strong relationship between CSC marker Lgr5 and vascular invasion, presence of lymph-node metastasis, and overall poor survival. The presence of Lgr5 might be an unfavorable prognostic factor, and its high level in cancer tissue is related to an aggressive course. This marker could also be used to access the effectiveness of the treatment. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - September 3, 2020 Category: Cancer & Oncology Source Type: research

Hypoxia-induced downregulation of B-cell translocation gene 3 confers resistance to radiation therapy of colorectal cancer
ConclusionWe therefore propose a novel signaling cascade involving hypoxia/BTG3 to be a potential risk factor for CRC patients undergoing radiation therapy, which could possibly serve as therapeutic targets among CRC patients with acquired radiotherapy resistance. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - September 3, 2020 Category: Cancer & Oncology Source Type: research

Role of pleural and peritoneal metastasis in immune checkpoint inhibitors efficacy patients with non-small cell lung cancer: real-world data from a large cohort in France
AbstractBackgroundCheckpoint inhibitors (CKI) targeting PD-1 or PD-L1 are major therapies for the treatment of non-small cell lung cancer (NSCLC). Despite numerous studies of biological biomarkers, we currently lack a marker to predict CKI primary resistance. The aim of this study was to isolate clinical markers associated with the absence of efficacy of CKI used as monotherapy in NSCLC.MethodsWe conducted a retrospective analysis of 172 patients treated with anti-PD1 or anti-PDL1 monoclonal antibodies (mAb) for advanced NSCLC at the Dijon Cancer Center. Baseline characteristics were compared using the Chi squared test bet...
Source: Journal of Cancer Research and Clinical Oncology - September 3, 2020 Category: Cancer & Oncology Source Type: research

Analyses of expressions and prognostic values of Polo-like kinases in non-small cell lung cancer
ConclusionsPLKs are relevant targets for NSCLC treatment, especially PLK1 and PLK4. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - September 3, 2020 Category: Cancer & Oncology Source Type: research

Low rectal cancer treatment strategies: a cohort study assessing watch and wait
ConclusionThe W&W strategy for low rectal cancer achieved the same oncological outcomes as the traditional strategy while sparing some patients from surgery. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - September 3, 2020 Category: Cancer & Oncology Source Type: research

Primary tumor standardized uptake value (SUVmax) measured on 18 F-FDG PET/CT and mixed NSCLC components predict survival in surgical-resected combined small-cell lung cancer
ConclusionSurgical-resected c-SCLCs have a relatively good prognosis. TNM stage is the most significant factor influencing disease progression in surgical-resected c-SCLCs. SUVmax and mixed NSCLC components within c-SCLCs had a considerable influence on the survival. Both high SUVmax and mixed SCC component are poor predictors for patients with c-SCLCs. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - September 3, 2020 Category: Cancer & Oncology Source Type: research

Dynamics in treatment response and disease progression of metastatic colorectal cancer (mCRC) patients with focus on BRAF status and primary tumor location: analysis of untreated RAS-wild-type mCRC patients receiving FOLFOXIRI either with or without panitumumab in the VOLFI trial (AIO KRK0109)
AbstractPurposeIn mCRC, disease dynamics may play a critical role in the understanding of long-term outcome. We evaluated depth of response (DpR), time to DpR, and post-DpR survival as relevant endpoints.MethodsWe analyzed DpR by central review of computer tomography images (change from baseline to smallest tumor diameter), early tumor shrinkage ( ≥ 20% reduction in tumor diameter at first reassessment), time to DpR (study randomization to DpR-image), post-DpR progression-free survival (pPFS = DpR-image to tumor progression or death), and post-DpR overall survival (pOS = DpR-image to d...
Source: Journal of Cancer Research and Clinical Oncology - September 3, 2020 Category: Cancer & Oncology Source Type: research

Combined microscope and endoscopy total resection of primary pineal malignant melanoma: case report and literature review
ConclusionCombined microscope and endoscopy total resection is beneficial to prolong the survival of patients. But the best approach to treatment needs verification from more clinical cases in future. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - September 3, 2020 Category: Cancer & Oncology Source Type: research

Polypharmacy as a prognostic factor in older patients with advanced non-small-cell lung cancer treated with anti-PD-1/PD-L1 antibody-based immunotherapy
AbstractPurposePolypharmacy is a common problem among older adults. However, its prevalence and impact on the clinical outcomes of anticancer treatment, such as survival and adverse events, in older patients with advanced cancer have not been well investigated.MethodsWe retrospectively reviewed data from Japanese patients treated with an immune checkpoint inhibitor (ICI) for advanced or recurrent non-small-cell lung cancer (NSCLC) between 2016 and 2019.ResultsAmong 157 older (aged  ≥ 65 years) patients, the prevalence of polypharmacy, defined as ≥ 5 medications, was 59.9% (94/157). Th...
Source: Journal of Cancer Research and Clinical Oncology - September 3, 2020 Category: Cancer & Oncology Source Type: research

Appropriate arrangement of cancer treatment after COVID-19 epidemic peaks in China
ConclusionThe rational arrangement we make now may be helpful to the future restoration of cancer treatments in other countries. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - September 3, 2020 Category: Cancer & Oncology Source Type: research

Preoperative biopsies as predictor for the necessity of inguinal lymph node surgery in squamous cell carcinoma of the vulva-a retrospective tertiary center analysis
ConclusionWe pointed, that only in 77.9% of the patients who should have undergo lymph node surgery based on the postoperative depth of infiltration underwent this procedure. Consequentially in 22.1% of the cases a second operation could not be prevented with a preoperative taken biopsy as indicator for the necessity of lymph node surgery. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - September 3, 2020 Category: Cancer & Oncology Source Type: research

Correction to: Afatinib is active in osteosarcoma cell lines
The title of the article is incorrectly published in the original article. The correct article title is “Afatinib is active in osteosarcoma cell lines”. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - September 3, 2020 Category: Cancer & Oncology Source Type: research

Clinical effectiveness of percutaneous vertebroplasty in conjunction with postoperative radiotherapy in the treatment of spinal metastases
ConclusionPVP in conjunction with postoperative RT is a good treatment strategy for vertebral compression fractures caused by metastases. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - September 2, 2020 Category: Cancer & Oncology Source Type: research

Non-small cell lung cancer patients with ex19del or exon 21 L858R mutation: distinct mechanisms, different efficacies to treatments
AbstractWith the development of antitumor therapies, different treatment methods including monotherapy and combined therapy have achieved clinical efficacy in advanced epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC) patients. Exon 19 deletion (ex19del) and exon 21 L858R mutation are common sensitive subtypes of EGFR mutation. However, potential distinct mechanisms are found from several dimensions including molecular structures, biological behaviors, concomitant mutations, resistance mechanisms and tumor mutation burdens. More evidence indicates the prognostic difference of EGFR subgroups....
Source: Journal of Cancer Research and Clinical Oncology - July 26, 2020 Category: Cancer & Oncology Source Type: research

Bone marrow adipocytes enhance osteolytic bone destruction by activating 1q21.3(S100A7/8/9-IL6R)-TLR4 pathway in lung cancer
ConclusionsOur study suggested that bone marrow adipocyte may communicate with lung cancer cells via 1q21.3 (S100A8/A9-IL6R)-TLR4 pathway to promote osteolytic bone destruction. 1q21.3 (S100A8/A9-IL6R) is a potential target for the treatment of lung cancer bone metastasis. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - July 26, 2020 Category: Cancer & Oncology Source Type: research

Mutational profiling of lung adenocarcinoma in China detected by next-generation sequencing
ConclusionMultiple mutations in LUAD patients in this study have not previously been reported in NSCLC. Moreover, mutations in driver genes includingEGFR,TP53,BCOR, BLM,WWTR1, andATR were significantly related to clinical features. The panel used in this study is an effective approach for molecular analysis and can be applied in personalized treatment decision-making and drug development. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - July 26, 2020 Category: Cancer & Oncology Source Type: research

The biological basis and function of GNAS mutation in pseudomyxoma peritonei: a review
ConclusionGNAS mutation is one of the most important molecular biological features in PMP, with major functions to promote mucin hypersecretion. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - July 26, 2020 Category: Cancer & Oncology Source Type: research

Prostaglandin E2 receptor 3 (EP3) signaling promotes migration of cervical cancer via urokinase-type plasminogen activator receptor (uPAR)
ConclusionThese results indicated that EP3 signaling pathway might facilitate the migration of cervical cancer cells through modulating uPAR expression. Therefore, EP3 and uPAR could represent novel therapeutic targets in the treatment of cervical cancer in advantaged stages. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - July 26, 2020 Category: Cancer & Oncology Source Type: research

Volumetric modulated arc therapy versus intensity-modulated proton therapy in the postoperative irradiation of thymoma
ConclusionThe data from this in-silico study suggest that intensity-modulated proton therapy could be significantly advantageous in the treatment of thymoma patients with particular emphasis to a substantial reduction of the risk of cardiac failure and secondary cancer induction. Robust planning is a technical pre-requisite for the safety of the delivery. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - July 26, 2020 Category: Cancer & Oncology Source Type: research

Ground-glass opacity-featured lung adenocarcinoma has no response to chemotherapy
ConclusionGGO-featured lung adenocarcinoma has no response to chemotherapy. For these patients, chemotherapy should not be a treatment option. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - July 26, 2020 Category: Cancer & Oncology Source Type: research

The effects of NLRP3 inflammasome inhibition by MCC950 on LPS-induced pancreatic adenocarcinoma inflammation
ConclusionThere is a dynamic interaction between inflammasome that regulates inflammasome-mediated inflammation in pancreatic adenocarcinoma cells. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - July 26, 2020 Category: Cancer & Oncology Source Type: research

Targeted deep sequencing helps distinguish independent primary tumors from intrapulmonary metastasis for lung cancer diagnosis
ConclusionAnalysis of overlapping mutations among different tumors assists physicians in distinguishing IPM from IPT. Our findings demonstrate that DNA sequencing can provide additional evidence in clinical practice when pathology is inadequate to make a conclusive diagnosis. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - July 26, 2020 Category: Cancer & Oncology Source Type: research

Lymphocyte activation gene-3 (LAG3) mRNA and protein expression on tumour infiltrating lymphocytes (TILs) in oesophageal adenocarcinoma
AbstractPurposeLymphocyte activation gene-3 (LAG3) is an immunosuppressive checkpoint molecule expressed on T cells. The frequency and distribution of LAG3 expression in oesophageal adenocarcinoma (EAC) is unknown. Aim of the study was the evaluation and distribution of LAG3 on tumour infiltrating lymphocytes (TILs) and correlation with clinico-pathological and molecular data.MethodsWe analysed tumor tissue samples using immunohistochemistry, multi-colour immunofluorescence and mRNA in-situ technology. The analyses were performed on a multi-spot tissue microarray (TMA) with 165 samples, followed by an evaluation on a singl...
Source: Journal of Cancer Research and Clinical Oncology - July 26, 2020 Category: Cancer & Oncology Source Type: research

Artificial intelligence in gastric cancer: a systematic review
ConclusionsIn the foreseeable future, AI applications can play an important role in gastric cancer management in the era of precision medicine. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - July 26, 2020 Category: Cancer & Oncology Source Type: research

Effects of adjuvant chemotherapy on survival of patients with stage IB non-small cell lung cancer with visceral pleural invasion
ConclusionIn our study, stage IB NSCLC did not benefit from adjuvant chemotherapy, even in patients with VPI. However, the significance of adjuvant chemotherapy in patients with VPI is still worth further exploration. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - July 26, 2020 Category: Cancer & Oncology Source Type: research

Stereotactic body radiotherapy in the management of oligometastatic and recurrent biliary tract cancer: single-institution analysis of outcome and toxicity
AbstractIntroductionBiliary tract cancers (BTC) are rare malignancies arising from biliary system. Systemic therapy is the cornerstone for stage IV disease, with poor overall survival (OS). Evidence is lacking about safety and efficacy of local ablative treatments, such as surgery and stereotactic body radiotherapy (SBRT) in the context of metastatic BTC (mBTC).Materials and methodsWe retrospectively analyzed clinical outcomes for a cohort of mBTC patients treated with SBRT for oligometastatic disease. Inclusion criteria were 1 –5 distant metastases; SBRT with a dose/fraction of a least 5 Gy to a biological effe...
Source: Journal of Cancer Research and Clinical Oncology - July 26, 2020 Category: Cancer & Oncology Source Type: research

PROLAPSE: survey about local prostate cancer relapse salvage treatment with external beam re-irradiation: results of the Italian Association of Radiotherapy and Clinical Oncology (AIRO)
ConclusionThis first AIRO survey about salvage prostate re-EBRT provides an interesting snapshot and suggests increasing interest in re-EBRT patients in Italy. Consensus about some aspects of patients ’ selection, the necessity of biopsy, fractionation, and highly selective techniques seems feasible, but other key points such as irradiated volume, dosimetry parameters, and hormonal treatment association need to be clarified. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - July 26, 2020 Category: Cancer & Oncology Source Type: research

Targeting glycolysis with 2-deoxy- d -glucose sensitizes primary cell cultures of renal cell carcinoma to tyrosine kinase inhibitors
ConclusionThis study presents a valuable tool to cultivate even uncommon and rare renal cancer subtypes and allows testing of targeted therapies as a personalized approach as well as testing new therapies such as glycolysis inhibition in an in vitro model. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - July 26, 2020 Category: Cancer & Oncology Source Type: research

Cholecystokinin type 2 receptor in colorectal cancer: diagnostic and therapeutic target
This study investigated CCK2R expression in a wide range of cell lines and clinical CRC samples, and explored expression pattern and prognostic value of CCK2R in relation to clinicopathological parameters. The location and expression levels of CCK2R were measured by immunocytochemical (ICC), qRT-PCR and Western blot. The druggability and antineoplastic effects of CCK2R as a therapeutic target were investigated using an anti-CCK2R targeting recombinant toxin named rCCK8PE38 by CCK-8 assay.ResultsCompared with paracarcinoma tissues, tumor samples showed overexpression of CCK2R (p = 0.028) including both CRC tis...
Source: Journal of Cancer Research and Clinical Oncology - July 26, 2020 Category: Cancer & Oncology Source Type: research

Selected protein expression in a new prognostic model for patients with non-muscle-invasive bladder cancer
AbstractIntroductionAfter transurethral resection of a bladder tumor, patients frequently have a recurrence of the disease, thereby requiring adjuvant therapy.PurposeThe study aimed to determine the prognostic value of expression levels of p53, Ki-67, and survivin, and to develop a new prognostic model for patients with non-muscle-invasive bladder cancer (NMIBC) after transurethral resection of a bladder tumor.MethodsThe study group consisted of 101 patients with primary NMIBC. Univariate followed by multivariate Cox proportional hazard regression analysis was performed to obtain a model including the smallest possible num...
Source: Journal of Cancer Research and Clinical Oncology - June 30, 2020 Category: Cancer & Oncology Source Type: research

SHCBP1 promotes tumor cell proliferation, migration, and invasion, and is associated with poor prostate cancer prognosis
ConclusionThese findings suggest that SHCBP1 overexpression contributes to PCa progression and that targeting SHCBP1 might be therapeutically beneficial to patients with PCa. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - June 30, 2020 Category: Cancer & Oncology Source Type: research

IL-10 c.-592C & gt;A (rs1800872) polymorphism is associated with cervical cancer
ConclusionOur study analyses show the association between cervical cancer andIL-10 c.-592C>A polymorphism, demonstrating that the allele A presence was independently associated with higher risks of cervical cancer development. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - June 30, 2020 Category: Cancer & Oncology Source Type: research

Expression of H3K4me3 and H3K9ac in breast cancer
ConclusionThis analysis provides new evidence of histone modifications in breast cancer. High H3K4me3 and H3K9ac expression was correlated with survival rates. Further investigation of histone modifications in breast cancer could lead to a more profound understanding of the molecular mechanisms of cancer development and could result in new therapeutic strategies. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - June 30, 2020 Category: Cancer & Oncology Source Type: research

Enhanced cytotoxicity against solid tumors by bispecific antibody-armed CD19 CAR T cells: a proof-of-concept study
ConclusionsHER2Bi- or EGFRBi-armed CART19 exhibited specific cytotoxicity against multiple HER2+/EGFR+/CD19− tumor targets in overnight and long-term serial killing assays. CART19 showed improved survival and were resistant to exhaustion after prolonged repeated exposure to tumor cells. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - June 30, 2020 Category: Cancer & Oncology Source Type: research

Cytoplasmic versus nuclear THR alpha expression determines survival of ovarian cancer patients
ConclusionDepending on nuclear or cytoplasmic expression, our study shows that THR α and its isoforms 1 and 2 provide different prognostic information for ovarian cancer patients. Further investigations should analyze if THRs may represent new endocrine targets for the treatment of ovarian cancer. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - June 30, 2020 Category: Cancer & Oncology Source Type: research

The paratumoral immune cell signature reveals the potential for the implementation of immunotherapy in esophageal carcinoma patients
ConclusionThe novel association of the disease state with tumoral and paratumoral immune cell signatures suggests new possibilities for personalized immunotherapy for EC patients. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - June 30, 2020 Category: Cancer & Oncology Source Type: research

A clinician ’s guide for developing a prediction model: a case study using real-world data of patients with castration-resistant prostate cancer
ConclusionThis study provides a comprehensive detailed guide to bridge the gap between the statistician and clinician, based on a large dataset of real-world patients treated for castration-resistant prostate cancer. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - June 30, 2020 Category: Cancer & Oncology Source Type: research

Vitamin and herbal supplements ’ use among patients with advanced gastrointestinal cancers included in eight clinical trials
AbstractObjectiveTo evaluate the patterns of vitamin and herbal supplement use among patients with advanced gastrointestinal (GI) cancers and the association of such behavior with the efficacy and toxicity of systemic anticancer treatment.MethodsProject data sphere (PDS) was used to access de-identified datasets of eight clinical trials of advanced GI cancers. Multivariable logistic regression analysis was used to identify factors predicting the use of supplements. Kaplan –Meier survival estimates were used to evaluate the association of supplement use with overall and progression-free survival. Results were stratifi...
Source: Journal of Cancer Research and Clinical Oncology - June 30, 2020 Category: Cancer & Oncology Source Type: research

Detection of miR-155-5p and imaging lung cancer for early diagnosis: in vitro and in vivo study
ConclusionBoth in vivo and in vitro experiments demonstrated that the CS-MB probe could be utilized to recognize the miR-155-5p and image the lung cancer cells. It provided a novel experimental and theoretical basis for the early diagnosis of the disease. Also, the histopathological sections of human lung cancer research laid the foundation for subsequent preclinical studies. In addition, different MBs could be designed to detect other miRNAs for the early diagnosis of other tumors. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - June 30, 2020 Category: Cancer & Oncology Source Type: research

Effect of aspirin use on neoadjuvant chemoradiotherapy for rectal cancer: a meta-analysis with trial sequential analysis
AbstractBackgroundNumerous studies have reported the preventive and protective effects of aspirin in patients with rectal cancer. However, it is not clear whether aspirin can be used as an assistance drug in preoperative neoadjuvant chemoradiotherapy. Therefore, this study will explore the efficacy of aspirin as an adjuvant agent in rectal cancer neoadjuvant chemoradiotherapy.MethodsA literature search was performed using the electronic platforms to obtain relevant research studies published up to Jan 2020. The search was limited to papers published in English or Chinese language. Confidence intervals of research endpoints...
Source: Journal of Cancer Research and Clinical Oncology - June 30, 2020 Category: Cancer & Oncology Source Type: research

Comparison of liquid-based to tissue-based biopsy analysis by targeted next generation sequencing in advanced non-small cell lung cancer: a comprehensive systematic review
ConclusionDespite many advantages, liquid biopsy might be unable to fully substitute its tissue counterpart in detecting clinically relevant mutations in advanced NSCLC patients. However, it may serve as a helpful tool when making therapeutic decisions. More studies are needed to evaluate its role in everyday clinical practice. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - June 30, 2020 Category: Cancer & Oncology Source Type: research

Current treatment options in RAS mutant metastatic colorectal cancer patients: a meta-analysis of 14 randomized phase III trials
ConclusionThe therapeutic benefit of additional substances is less distinct in patients withRAS mutated as compared toRAS wildtype metastatic colorectal cancer, especially with regard to OS. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - June 30, 2020 Category: Cancer & Oncology Source Type: research

Treatment discontinuation and re-initiation of anti-PD-(L)1 agents in metastatic cancers
ConclusionsOur study shows that long IO-free periods can be achieved with limited duration of anti-PD-(L)1 therapy with excellent survival outcomes, and that anti-PD-(L)1 re-challenge is feasible in clinical practice. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - June 30, 2020 Category: Cancer & Oncology Source Type: research

Harvest of at least 18 lymph nodes is associated with improved survival in patients with pN0 colon cancer: a retrospective cohort study
AbstractPurposeTo investigate the correlation between number of retrieved lymph nodes (rLNs) and prognosis and further ascertain the optimal number of rLNs with a beneficial survival impact in patients with pN0 colon cancer.MethodsThe Surveillance, Epidemiology, and End Results (SEER) database was searched for pN0 colon cancer cases. X-Tile software and Kaplan –Meier survival analysis were applied to determine the optimal number of rLNs based on the minimal probability (P) value and the largestχ2 value. Univariate analyses and Cox proportional hazard regression model were used to investigate the relationship betw...
Source: Journal of Cancer Research and Clinical Oncology - June 30, 2020 Category: Cancer & Oncology Source Type: research