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Taxane, platinum and 5-FU prior to chemoradiotherapy benefits patients with stage IV neck node-positive head and neck cancer and a good performance status
ConclusionWith prophylactic antibiotics and granulocyte colony-stimulating factor TPF was well tolerated with good survival outcomes. TPF should remain a treatment option for stage IV neck node-positive patients with a good performance status. The use of tumour grade to aid patient selection for TPF warrants investigation. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 8, 2017 Category: Cancer & Oncology Source Type: research

High-intensity exercise interventions in cancer survivors: a systematic review exploring the impact on health outcomes
ConclusionHigh-intensity exercise interventions improved physical and physiological health-related outcome measures such as cardiovascular fitness and strength in cancer survivors. Given that high-intensity exercise sessions require a shorter time commitment, it may be a useful modality to improve health outcomes in those who are time poor. The risk of adverse events associated with high-intensity exercise was low. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 5, 2017 Category: Cancer & Oncology Source Type: research

A comparison of tumour size measurements with palpation, ultrasound and mammography in male breast cancer: first results of the prospective register study
ConclusionsOur data demonstrate that MG and US have similar accuracy with regard to tumour size estimation. US assessment showed the highest sensitivity in determining tumour size, followed by MG and CE. However, MG demonstrated a significant advantage for estimating the real tumour size for pT2 tumours compared to US or CE. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 4, 2017 Category: Cancer & Oncology Source Type: research

Effects of nutraceuticals on anaplastic thyroid cancer cells
ConclusionsAltogether, our results clearly indicate the anti-cancer proprieties of curcumin, suggesting the promising use of this nutraceutical in ATC treatment. Resveratrol, genistein and EGCG have heterogeneous effects on molecular features of ATC cells. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 2, 2017 Category: Cancer & Oncology Source Type: research

Systemic Inflammation Response Index (SIRI), cancer stem cells and survival of localised gastric adenocarcinoma after curative resection
AbstractPurposeSystemic Inflammation Response Index (SIRI), based on peripheral neutrophil, monocyte, and lymphocyte counts, was recently developed and used as a marker to predict the survival of patients with malignant tumours. Cancer stem cells (CSCs) can contribute to gastric cancer progression and recurrence. It is not clear whether SIRI is associated with CSCs during gastric cancer development.MethodsThe SIRI was developed in a training cohort of 455 gastric cancer patients undergoing curative resection between 2007 and 2009, and validated in a validation cohort of 327 patients from 2010 to 2011. CD44  + CSC...
Source: Journal of Cancer Research and Clinical Oncology - November 17, 2017 Category: Cancer & Oncology Source Type: research

Human cancer stem cells are a target for cancer prevention using ( −)-epigallocatechin gallate
ConclusionsGreen tea prevents human cancer, and the combination of EGCG and anticancer drugs confers cancer treatment with tissue-agnostic efficacy. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 17, 2017 Category: Cancer & Oncology Source Type: research

Survival benefit of pelvic and paraaortic lymphadenectomy in high-grade endometrial carcinoma: a retrospective population-based cohort analysis
This study included 284 patients who are recorded in the German Tumor Centre Regensburg form 1998 to 2015 and were selected by cancer grading, the absence of secondary tumors, primary surgery including hysterectomy and available follow-up. 244 of the 284 patients in this cohort were unequivocally classified as R0 after resection.ResultsA significantly increased overall survival was observed for systematic LND of 25 or more paraaortic and pelvic lymph nodes versus patients who did not undergo such intervention (p 
Source: Journal of Cancer Research and Clinical Oncology - November 17, 2017 Category: Cancer & Oncology Source Type: research

The more from East-Asian, the better: risk prediction of colorectal cancer risk by GWAS-identified SNPs among Japanese
ConclusionWe constructed a more efficient CRC risk prediction model with 11 SNPs including newly identified East Asian-based GWAS SNPs (rs704017, rs11196172, rs10774214, rs647161, rs2423279). Risk grouping based on 11 SNPs depicted lifetime difference of CRC risk. This might be useful for effective individualized prevention for East Asian. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 17, 2017 Category: Cancer & Oncology Source Type: research

Identification of prognostic markers of high grade prostate cancer through an integrated bioinformatics approach
ConclusionThe present study applied integrate bioinformatics approaches to generate a holistic view of high grade prostate cancer and identified hub genes could serve as prognosis markers and potential treatment targets. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 17, 2017 Category: Cancer & Oncology Source Type: research

Modifiable health-related factors (smoking, physical activity and body mass index) and health care use and costs among adult cancer survivors
We examined health-related factors, demographics, insurance and health status (i.e., comorbidity and mental distress). Bivariate and multivariable analyses examined the associations between outcomes and health-related factors.ResultsOf survivors, approximately 21% were current smokers, 52% reported low physical activity and 35% were obese, vs. 19.6, 49.5 and 36.7%, respectively, of the comparison group. These factors were associated with greater comorbidity and mental distress in both groups. Current smokers among survivors were less likely to have outpatient visits [marginal effect on the  number of visits (ME) ...
Source: Journal of Cancer Research and Clinical Oncology - November 17, 2017 Category: Cancer & Oncology Source Type: research

Validity of eleven prognostic scores with respect to intra- and extrahepatic recurrence of hepatocellular carcinoma after liver transplantation
AbstractIntroductionTumor recurrence is the most frequent cause of death after liver transplantation for hepatocellular carcinoma. We selected ten other prognostic classifications to evaluate their potential to predict the risk of recurrence after LT for HCC as compared to the Milan classification. All of the other scores have not been compared with one another in a single cohort.MethodsData of 147 consecutive patients transplanted at our department between 1996 and 2014 were analyzed and staged for morphological and functional scores of underlying liver disease. For long-term follow-up, we analyzed intrahepatic (within th...
Source: Journal of Cancer Research and Clinical Oncology - November 17, 2017 Category: Cancer & Oncology Source Type: research

Prognostic stratification of patients with metastatic nasopharyngeal carcinoma using a clinical and biochemical scoring system
AbstractPurposeMetastatic nasopharyngeal cancer (NPC) is known to have poor survival outcomes. Clinical and biochemical parameters may impact survival outcomes among patients with metastatic NPC and may be used for prognostication.MethodsOne-hundred and fifty-eight patients with metastatic NPC treated at a single tertiary institution were analyzed retrospectively. Multivariate analysis was carried out on patients who were given disease control treatment (n = 135). A numerical score derived from the regression coefficients of each identified independent variable was used to create prognostic groups (PG). Ap value ...
Source: Journal of Cancer Research and Clinical Oncology - November 17, 2017 Category: Cancer & Oncology Source Type: research

Meeting report of the 6th Heidelberg Myeloma Workshop: current status and developments in diagnosis and therapy of multiple myeloma
ConclusionThe landscape for the treatment of newly diagnosed and relapsed disease has significantly changed since the last Heidelberg Myeloma Workshop in 2015. Updates on the current developments were presented at the meeting. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 17, 2017 Category: Cancer & Oncology Source Type: research

Head and neck rhabdomyosarcoma in children: a 20-year retrospective study at a tertiary referral center
ConclusionMultimodality treatment of rhabdomyosarcomas of the head and neck in pediatric patients may lead to a 5-year overall survival of up to 91.3%. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 16, 2017 Category: Cancer & Oncology Source Type: research

Epigenetic silencing of ADAMTS5 is associated with increased invasiveness and poor survival in patients with colorectal cancer
AbstractPurposeA disintegrin and metalloprotease with motif 5(ADAMTS5) has been involved in colorectal cancer (CRC) with hypermethylation in the promoter. However, its role in CRC remains unclear. The aim of this study was to explore the clinical significance and biological effect of ADAMTS5 on colorectal carcinogenesis. Through MSP, qRT-PCR, WB and IHC analysis, followed by a variety of in vitro assays, we report the function of ADAMTS5 in CRC. ADAMTS5 was markedly hypermethylaed and downregulated in tumor tissues compared with non-tumor tissues (p 
Source: Journal of Cancer Research and Clinical Oncology - November 15, 2017 Category: Cancer & Oncology Source Type: research

Early recurrence in patients undergoing curative resection of colorectal liver oligometastases: identification of its clinical characteristics, risk factors, and prognosis
This study aimed to investigate the clinical characteristics, risk factors, and prognosis related to early recurrence in these patients.MethodsA total of 307 consecutive patients with CLOM undergoing curative liver resection were retrospectively reviewed between September 1999 and June 2016. Early recurrence was defined as any recurrence or death from CLOM that occurred within 6  months of liver resection.ResultsWith a median follow-up time of 31.7  months, the 3-year overall survival (OS) and recurrence-free survival rates were 68.7 and 42.5%, respectively. Forty-nine (16.0%) patients developed early recurrence ...
Source: Journal of Cancer Research and Clinical Oncology - November 11, 2017 Category: Cancer & Oncology Source Type: research

Knockdown of LncRNA ANRIL suppresses cell proliferation, metastasis, and invasion via regulating miR-122-5p expression in hepatocellular carcinoma
ConclusionOur finding suggested that knockdown of ANRIL suppressed cell proliferation, metastasis and invasion via regulating miR-122-5p expression in HCC, illustrating the underlying mechanism of the oncogenic role of ANRIL in HCC. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 10, 2017 Category: Cancer & Oncology Source Type: research

Reviewer Acknowledgements 2017
(Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 9, 2017 Category: Cancer & Oncology Source Type: research

Preferential expression of NY-BR-1 and GATA-3 in male breast cancer
ConclusionWe found a high sensitivity for all the markers analyzed. Moreover, the expression of NY-BR-1 and GATA-3 seemed the most effective for labelling male breast cancer in primary and metastatic setting. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 7, 2017 Category: Cancer & Oncology Source Type: research

Model-based optimization of G-CSF treatment during cytotoxic chemotherapy
ConclusionsWe conclude that we established a model of human granulopoiesis under chemotherapy which allows predictions of yet untested G-CSF schedules, comparisons between them, and optimization of filgrastim and pegfilgrastim treatment. As a general rule of thumb, G-CSF treatment should not be started too early and patients could profit from filgrastim treatment continued until the end of the chemotherapy cycle. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 4, 2017 Category: Cancer & Oncology Source Type: research

SIRT3 deacetylates and promotes degradation of P53 in PTEN-defective non-small cell lung cancer
ConclusionsWe have identified a novel mechanism by which P53 was inactivated via SIRT3 in PTEN-deficient cells. This may shed light on the mechanisms underlying the malignancy of PTEN-deficient NSCLC. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 4, 2017 Category: Cancer & Oncology Source Type: research

Survival benefit of tamoxifen and aromatase inhibitor in male and female breast cancer
ConclusionsThe OS of TAM-treated patients with MBC was similar to the OS of TAM-treated FBC patients, whereas AI treatment is associated with poorer survival of MBC patients. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 2, 2017 Category: Cancer & Oncology Source Type: research

Additive naftopidil treatment synergizes docetaxel-induced apoptosis in human prostate cancer cells
ConclusionsOur results demonstrated that additive naftopidil treatment in combination with DTX increased the efficacy of DTX for the treatment of LNCaP and PC-3 tumors in vivo. Thus, additive naftopidil treatment showed a synergistic effect on DTX-induced apoptosis in PCa cells in vitro and in vivo, suggesting that this treatment approach may yield improved clinical benefits compared with DTX alone. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 2, 2017 Category: Cancer & Oncology Source Type: research

Molecular alterations in a new cell line (KU-Lu-MPPt3) established from a human lung adenocarcinoma with a micropapillary pattern
ConclusionsThis cell line represents a new model system for molecular studies of lung adenocarcinoma which may be suitable for investigation of cancer spread and also for development of molecular-targeting and immunotherapies, both in vitro and in vivo. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 1, 2017 Category: Cancer & Oncology Source Type: research

Impact of adjuvant chemotherapy after neoadjuvant radio- or radiochemotherapy for patients with locally advanced rectal cancer
AbstractBackgroundDue to its primarily extraperitoneal location, potential affection of the anorectal continence and different metastatic behavior the rectal carcinoma (RC) is classified and treated as an independent disease. Over the past few decades various trials have led to improved multimodal therapies (including radiation, chemotherapy and surgery) for locally advanced rectal cancer and significant changes in the management of this disease whereas the benefit of adjuvant chemotherapy remains unclear.MethodsBased on a prospective tumor register of the University Hospital of Wuerzburg data of 263 patients having und...
Source: Journal of Cancer Research and Clinical Oncology - October 13, 2017 Category: Cancer & Oncology Source Type: research

Opa interacting protein 5 acts as an oncogene in bladder cancer
ConclusionsOur work demonstrated that OIP5 might function as an oncogene to promote colony formation capacity and cell growth, arrest cell cycle and suppress cell apoptosis in bladder cancer. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - October 13, 2017 Category: Cancer & Oncology Source Type: research

Overexpression of glutathione peroxidase 1 predicts poor prognosis in oral squamous cell carcinoma
This study included 233 patients who underwent curative surgery for previously untreated OSCC between 2000 and 2012. Tumour GPX1, GPX4, and TrxR1 expression was evaluated by immunohistochemistry and was dichotomised to low and high values according to defined expression levels. The association between GPX1, GPX4, and TrxR1 expression and clinicopathological results was analysed. Univariate and multivariate analyses using the Cox proportional hazards model were conducted to assess the significance of differences in recurrence or survival outcomes between variables.ResultsHigh GPX1, GPX4, and TrxR1 expression was observed in...
Source: Journal of Cancer Research and Clinical Oncology - October 13, 2017 Category: Cancer & Oncology Source Type: research

A novel interplay between HOTAIR and DNA methylation in osteosarcoma cells indicates a new therapeutic strategy
ConclusionThese results not only enrich our understanding of the regulation relationship between non-coding RNA, DNA methylation, and gene expression, however, also provide a novel direction in developing more sophisticated therapeutic strategies for OS patients. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - October 13, 2017 Category: Cancer & Oncology Source Type: research

eHealth literacy, Internet and eHealth service usage: a survey among cancer patients and their relatives
ConclusionIn a modern health care system, emphasis should be on skills contributing to eHealth literacy among patients to improve their ability to profit from eHealth offers and improve health care. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - October 13, 2017 Category: Cancer & Oncology Source Type: research

Unmonitored use of herbal medicine by patients with breast cancer: reframing expectations
AbstractPurposeTo identify the unmonitored use of herbal medicine by female patients with breast cancer, examining the impact of an integrative physician (IP) consultation on this practice.MethodsThe files of 269 female patients with breast cancer following an IP consultation were surveyed retrospectively for use of herbal medicine for cancer-related goals. Expectations from the IP consultation and adherence to the IP-guided treatments were examined as well.ResultsAmong the cohort, 111 (41.3%) reported using herbal medicine for cancer-related goals, unmonitored by their oncology healthcare professional. Factors predicting ...
Source: Journal of Cancer Research and Clinical Oncology - October 13, 2017 Category: Cancer & Oncology Source Type: research

Disseminated tumor cells are not associated with established risk factors, L1CAM immunoreactivity and outcome in endometrial carcinoma
ConclusionsWe were able to confirm previous findings of DTC presence in a large well-characterized cohort of endometrial carcinoma patients. DTC are detectable in almost one-fifth of endometrial carcinoma and occur less frequently with a MELF pattern of invasion. Further studies investigating the role of DTC in endometrial carcinoma are warranted. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - October 13, 2017 Category: Cancer & Oncology Source Type: research

EZH2 is involved in silencing of WNT5A during epithelial –mesenchymal transition of colon cancer cell line
ConclusionsOur results indicate that EZH2 was essential for the silencing of WNT5A during TGF- β-induced epithelial–mesenchymal transition of colon cancer cells. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - October 13, 2017 Category: Cancer & Oncology Source Type: research

Spectrophotometric photodynamic detection involving extracorporeal treatment with hexaminolevulinate for bladder cancer cells in voided urine
This study included 50 patients with bladder cancer that was confirmed histologically after transurethral resection (bladder cancer group) and 50 outpatients without a history of urothelial carcinoma or cancer-related findings (no malignancy group). One third of the voided urine samples were incubated with aminolevulinic acid (ALA-treated samples), one third were incubated with HAL (HAL-treated samples), and the remaining samples were incubated without treatment (untreated samples). For detecting cellular protoporphyrin IX levels, the intensity of the samples at the excitation wavelength of 405  nm was measured using ...
Source: Journal of Cancer Research and Clinical Oncology - October 13, 2017 Category: Cancer & Oncology Source Type: research

All-treatment array of hepatocellular carcinoma from initial diagnosis to death: observation of cumulative treatments
AbstractPurposeIn clinical practice, most patients with hepatocellular carcinoma require subsequent treatments for remaining, progressing, or recurring tumors. We investigated all-treatment array and outcomes in an HCC cohort from initial diagnosis to death.MethodsWe enrolled 1687 consecutive patients with HCC who underwent initial diagnosis and treatment at the National Cancer Center, Korea, from January 2004 to December 2009.ResultsIn total, 1357 patients (80.4%) showed RPRTs during median 20.4-month follow-up. Initial transplantation resulted in the least rate (32.3%) of RPRTs. Median treatment frequency was 3.0 times (...
Source: Journal of Cancer Research and Clinical Oncology - October 13, 2017 Category: Cancer & Oncology Source Type: research

Clinical utility of a blood-based protein assay to increase screening of elevated-risk patients for colorectal cancer in the primary care setting
AbstractPurposeColorectal cancer (CRC) screening  is effective in finding early stage CRC and dramatically improves survival rates. Despite this, the number of eligible patients who do not obtain CRC screening is unacceptably high.MethodsWe conducted a longitudinal, randomized controlled trial investigating the utility of a blood-based protein assay on the quality of care delivered by practicing PCPs in the United States. We used standardized simulated patients (CPVs), presenting with symptoms suggestive of a higher likelihood of CRC, to measure how frequently these PCPs ordered diagnostic colonoscopy. 190 PCPs cared ...
Source: Journal of Cancer Research and Clinical Oncology - October 13, 2017 Category: Cancer & Oncology Source Type: research

Large-scale comprehensive immunohistochemical biomarker analyses in esophageal squamous cell carcinoma
ConclusionsThis large cohort study demonstrated that multiple molecules were co-expressed in most of the ESCC cases, suggesting that combining molecular targeted agents for these co-expressed molecules should be considered. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - October 13, 2017 Category: Cancer & Oncology Source Type: research

Are exon 19 deletions and L858R different in early stage lung adenocarcinoma?
AbstractIntroductionEvidence shows that exon 19 deletions (19del) and exon 21 Leu858Arg point mutation (L858R) ofEGFR are different in response to EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy in advanced lung cancers. However, the impact of the two mutational types in the early stage lung adenocarcinoma is unknown.MethodsWe enrolled consecutive patients with operable adenocarcinoma which harbored 19del or L858R to investigate the clinicopathologic characteristics and prognostic outcomes.ResultsBetween 2008 and 2013, a total of 607 patients with 19del (47.9%) or L858R (52.1%) were included in this study. Clinicopatholo...
Source: Journal of Cancer Research and Clinical Oncology - October 12, 2017 Category: Cancer & Oncology Source Type: research

Prevalence of fibroblast growth factor receptor 1 (FGFR1) amplification in squamous cell carcinomas of the head and neck
ConclusionsHead and neck cancers are recurrently affected by FGFR1 amplification, with a predominance in cancers of the oral cavity. Finding only one HPV positive and FGFR1 amplified cancer argues against a causal relationship between HPV and FGFR1 amplifications. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - October 11, 2017 Category: Cancer & Oncology Source Type: research

Survival benefit of mantle cell lymphoma patients enrolled in clinical trials; a joint study from the LYSA group and French cancer registries
AbstractPurposeMantle cell lymphoma (MCL) is a rare non-Hodgkin ’s lymphoma entity with a poor prognosis. Therapeutic advances have improved the survival of patients enrolled in clinical trials; however, their impact on patients outside clinical trials remains unclear. In this work, we compared patient outcome inside and outside clinical trials.MethodsWe identified MCL patients recorded in six French population-based registries between 2008 and 2012 to perform a comparison with patients enrolled in two prospective multicenter MCL clinical trials conducted by the LYSA group during the same period. Variables associated...
Source: Journal of Cancer Research and Clinical Oncology - October 11, 2017 Category: Cancer & Oncology Source Type: research

Cannabinoid receptor 2 as a novel target for promotion of renal cell carcinoma prognosis and progression
ConclusionsCB2 expression is functionally related to cellular proliferation, migration, and cell cycle of RCC cells. Our data suggest that CB2 might be a potential therapeutic target for RCC. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - October 9, 2017 Category: Cancer & Oncology Source Type: research

Drug-eluting bead transarterial chemoembolization in the treatment for unresectable soft tissue sarcoma refractory to systemic chemotherapy: a preliminary evaluation of efficacy and safety
ConclusionsOur data showed that DEB-TACE was effective and safe for patients with soft tissue sarcoma. Therefore, DEB-TACE can be considered as an alternative treatment option for unresectable soft tissue sarcoma refractory to conventionally systemic chemotherapy. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - October 9, 2017 Category: Cancer & Oncology Source Type: research

A revision of the Tokuhashi revised score improves the prognostic ability in patients with metastatic spinal cord compression
AbstractPurposeThe Tokuhashi revised score from 2005 (TR2005) is the most recommended prognostic scoring system in patients with metastatic spinal cord compression (MSCC). However, recent studies have questioned its prognostic ability and the need for a new revision has been proposed. We aimed to assess whether a revision of the TR2005 can improve the prognostic ability of the scoring system.MethodsIn 2011 and 2012, a total of 1143 consecutive patients admitted with MSCC were prospectively included in a 2011 and a 2012 cohort. For the patients admitted in 2011 (n = 544), the components of the TR2005 including pri...
Source: Journal of Cancer Research and Clinical Oncology - October 6, 2017 Category: Cancer & Oncology Source Type: research

Causes of death and competing risk analysis of the associated factors for non-small cell lung cancer using the Surveillance, Epidemiology, and End Results database
ConclusionsMost of the patients with NSCLC died from lung cancer. Rational surveillance and treatment policies should be made for them. Early stage and lobectomy or bilobectomy were associated with improved OS and LCSS. It is reasonable to focus on early detection and optimal surgical treatment for NSCLC. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - October 4, 2017 Category: Cancer & Oncology Source Type: research

Sentinel lymph node mapping in endometrial cancer: comparison of fluorescence dye with traditional radiocolloid and blue
AbstractSentinel lymph node (SLN) mapping in endometrial cancer (EMCA) is rapidly gaining acceptance in the clinical community. As compared to a full lymphadenectomy in every patient, to a selective lymphadenectomy after frozen section of uterus in selected patients with intrauterine risk factors or to a strategy in which a lymphadenectomy is always omitted, SLN mapping seems to be a reasonable and oncologically safe middle ground. Various protocols can be used when applying an SLN mapping. In this manuscript we review the characteristics, toxicity and clinical impact of technetium-99m radiocolloid (Tc-99m), of the blue dy...
Source: Journal of Cancer Research and Clinical Oncology - September 14, 2017 Category: Cancer & Oncology Source Type: research

Clinical course and end-of-life care in patients who have died after allogeneic stem cell transplantation
ConclusionThe present investigation indicates that the somatic, psychic and spiritual end-of-life-care after allogeneic stem cell transplantation could be optimised. A significant problem for the transplantation team seems to be the realisation of necessity to switch the curative concept into a palliative ambition. Requirements are a subsequent prospectively conducted investigation and an intensification of cooperation between transplant and palliative care teams. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - September 14, 2017 Category: Cancer & Oncology Source Type: research

Successful treatment of patients with newly diagnosed/untreated light chain multiple myeloma with a combination of bendamustine, prednisone and bortezomib (BPV)
AbstractIntroductionPatients with light chain myeloma frequently have a light chain tubular cast nephropathy, which can lead to severe renal impairment. In the present retrospective study, bortezomib was combined with other active substances like bendamustine and prednisone (BPV), in order to assess the efficacy and toxicity of the combination therapy in patients with light chain multiple myeloma.MethodsBetween September 2008 and May 2015, 25 patients with newly diagnosed light chain multiple myeloma were treated with bendamustine 60  mg/m2 on days 1 and 2, bortezomib 1.3  mg/m2 on days 1, 4, 8 and 11, and predni...
Source: Journal of Cancer Research and Clinical Oncology - September 14, 2017 Category: Cancer & Oncology Source Type: research

Hepatic arterial infusion chemotherapy for extensive liver metastases of breast cancer: efficacy, safety and prognostic parameters
AbstractPurposeHepatic arterial infusion chemotherapy (HAIC) is an option for patients with liver-predominant metastatic breast cancer (LMBC), when no further systemic treatment is available. But systematic reports are limited. Here we conducted a retrospective analysis of LMBC patients treated at an expert center.MethodsIndividual patient data were retrieved from the clinical data base of the West German Cancer Center. Primary endpoints included hepatic response (RECIST), progression-free survival (PFS), overall survival (OS), and toxicity. A score based on LDH, AST, ALT and bilirubine was developed to estimate the hepati...
Source: Journal of Cancer Research and Clinical Oncology - September 14, 2017 Category: Cancer & Oncology Source Type: research

AXL –GAS6 expression can predict for adverse prognosis in non-small cell lung cancer with brain metastases
AbstractPurposePatients with non-small cell lung cancer (NSCLC) brain metastases (BM) have poor clinical outcomes. We sought to determine if AXL –GAS6 expression can be used as independent prognostic biomarkers for NSCLC BM.MethodsWe retrospectively studied the medical records of 98 patients diagnosed with advanced metastatic NSCLC from December 2000 to June 2014. Out of a total of 98 patients with NSCLC metastases, 66 patients were identified to have brain metastases. The expressions of AXL and GAS6 were assessed by standard immunohistochemistry and correlated with clinicopathological factors and overall survival (O...
Source: Journal of Cancer Research and Clinical Oncology - September 14, 2017 Category: Cancer & Oncology Source Type: research

An analysis of the kinetics of molecular response during the first trimester of treatment with nilotinib in newly diagnosed chronic myeloid leukemia patients in chronic phase
ConclusionsThe association of a shorter HT with response provides a rationale for exploring very early kinetics patterns in all patients treated with potent TKIs such as nilotinib. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - September 14, 2017 Category: Cancer & Oncology Source Type: research

Does rarity mean imparity? Biological characteristics of osteosarcoma cells originating from the spine
ConclusionWe have established a novel osteosarcoma cell line NEO217 derived from the spine, which will provide a useful model for biological or therapeutical studies of spinal osteosarcoma. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - September 14, 2017 Category: Cancer & Oncology Source Type: research