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A semi-supervised ensemble clustering algorithm for discovering relationships between different diseases by extracting cell-to-cell biological communications
ConclusionThe maximum cell-to-cell biological similarity in each cluster can be used to detect the relationship between different diseases such as cancer. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 2, 2024 Category: Cancer & Oncology Source Type: research

Gastroenteropancreatic neuroendocrine carcinoma in children and adolescents: a population-based study
ConclusionsOur study revealed that only the primary site was found to be the most important predictor of the OS in pediatric GEP-NEC. It ’s important to work closely with a multidisciplinary team, including oncologists, surgeons, and other specialists, to determine the most appropriate treatment plan for pediatric GEP-NEC. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 2, 2024 Category: Cancer & Oncology Source Type: research

Effect of radiation therapy on patients with stage T3 or T4 malignant phyllodes tumors: a retrospective observational study based on SEER
ConclusionBased on the SEER database analysis, the study suggests that the patients with stage T3 or T4 MPTB treated with RT after surgery didn't have significant differences in BCSS or OS compared to those not treated with RT. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 28, 2023 Category: Cancer & Oncology Source Type: research

Omission of axillary lymph node dissection in breast cancer patients with micrometastasis or isolated tumor cells in sentinel lymph nodes: a 12-year experience in a tertiary breast unit
DiscussionAvoiding ALND may be safe in pN1mi/pN0(i+) patients. Besides, we strongly encourage clinicians to develop their own follow-up protocols based on the best available evidence, to rapidly identify and treat breast cancer recurrence. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 27, 2023 Category: Cancer & Oncology Source Type: research

A systematic review and meta-analysis of prognostic indicators in patients with head and neck malignancy treated with immune checkpoint inhibitors
ConclusionIn our meta-analysis, different immune checkpoint factors were associated with different prognoses in HNSCC patients receiving immunotherapy. HPV, PD-L1, BMI, Alb, HPD, PS, GPS/mGPS, LDH, NLR, and PLR predicted the ICI outcome in HNSCC patients. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 11, 2023 Category: Cancer & Oncology Source Type: research

Intratumoral delivery of a Tim-3 antibody-encoding oncolytic adenovirus engages an effective antitumor immune response in liver cancer
Conclusion and ImplicationsThese results highlighted the promising therapeutic effects of Ad-GD55 –α-TIM-3 oncolytic adenovirus against HCC in vitro and in vivo. As such, this Ad-GD55–α-TIM-3 oncolytic adenovirus may represent a viable approach to the treatment of hepatocellular carcinoma. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 11, 2023 Category: Cancer & Oncology Source Type: research

Mortality due to non-AIDS-defining cancers among people living with HIV in Spain over 18  years of follow-up
ConclusionNon-AIDS cancers are an important cause of death among PLWH. The excess mortality related to certain malignancies and the association with immunodeficiency, smoking, and coinfections highlights the need for early detection and treatment of cancer in this population. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - December 1, 2023 Category: Cancer & Oncology Source Type: research

Brain metastases of sarcoma: a rare phenomenon in rare tumours
AbstractThe usual site for distant metastases of sarcoma is lungs, while brain metastasis (BM) occurs much less frequently and usually late in the disease progression. Despite the advancement in cancer treatment, the outcome for patients with brain metastasis is poor, and their lifespan is short. The frequency of BM in sarcoma seems to be affected by the location and histology of the primary tumour. Sarcoma subtypes with a high propensity for brain metastasis are ASPS, leiomyosarcoma and osteosarcoma. There are no clear guidelines for the treatment of sarcoma brain metastasis. However, therapeutic options include surgery, ...
Source: Journal of Cancer Research and Clinical Oncology - December 1, 2023 Category: Cancer & Oncology Source Type: research

Breast cancer prediction using different machine learning methods applying multi factors
ConclusionBreast cancer has several risk factors. Medical experts use these risk factors for early diagnosis. Therefore, identifying related risk factors and their effect can increase the accuracy of diagnosis. Considering the broad features for predicting breast cancer leads to the development of a comprehensive prediction model. In this study, using RF technique a breast cancer prediction model with 99.3% accuracy was developed based on multifactorial features. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 18, 2023 Category: Cancer & Oncology Source Type: research

The value of an apparent diffusion coefficient histogram model in predicting meningioma recurrence
ConclusionThis model based on conventional MRI features and ADC histogram parameters can directly and reliably predict meningioma recurrence, providing a guiding basis for selecting treatment options and individualized treatment. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 18, 2023 Category: Cancer & Oncology Source Type: research

Emerging markers of cancer cachexia and their relationship to sarcopenia
ConclusionSignificant relationships and differences of haemoglobin, CRP and albumin supports future use of these biomarkers in cancer cachexia. CXCL5 and H3Cit as valuable biomarkers in cancer cachexia remains to be defined. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 18, 2023 Category: Cancer & Oncology Source Type: research

Herpes zoster is not associated with subsequent gastrointestinal cancer: data from over 200,000 outpatients in Germany
ConclusionIn this retrospective cohort study consisting of well-matched patients, we observed no significant association between a HZ infection and the development of GI cancer during a long-term follow-up. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 18, 2023 Category: Cancer & Oncology Source Type: research

Constitutive photomorphogenic protein 1 ubiquitinates interleukin-1 receptor accessory protein in human liver cancer
ConclusionCOP1 regulates IL1RAP, which in turn results in activation of the NF- κB signaling. Our findings suggest that the COP1/IL1RAP/NF-κB axis promotes proliferation of liver cancer cells and is a potential target for the treatment of liver cancer. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 15, 2023 Category: Cancer & Oncology Source Type: research

Identification of SAA1 as a novel metastasis marker in ovarian cancer and development of a graphene-based detection platform for early assessment
ConclusionOur study suggests that SAA1 is a biomarker of OC metastasis, and we have developed a rapid and highly sensitive platform using graphene chips to detection of plasma SAA1 for the early assessment of metastasis in OC patients. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 15, 2023 Category: Cancer & Oncology Source Type: research

Quality of evidence supporting the role of acupuncture for breast cancer-related lymphoedema: an overview of systematic reviews and meta-analyses
ConclusionsAcupuncture may be beneficial in improving BCRL. However, due to the identified limitations and conflicting findings, further more prescriptive and rigorous SRs/MAs are required to give strong evidence for final judgments. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - November 15, 2023 Category: Cancer & Oncology Source Type: research