Journal of Cancer Research and Clinical Oncology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Lifetime risks of second primary malignancies after pediatric Hodgkin lymphoma and non-Hodgkin lymphoma
ConclusionOverall, patients after pediatric lymphoma can be with high lifetime risk of SPM, and more attention should be paid to SPM-related signs for early detection and intervention. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 27, 2024 Category: Cancer & Oncology Source Type: research

Short-term serial circulating tumor DNA assessment predicts therapeutic efficacy for patients with advanced pancreatic cancer
ConclusionThis short-term ctDNA kinetics assessment may provide predictive information to reflect real-time therapeutic response and lead to effective refinement of regimen in patients with advanced pancreatic cancer undergoing systemic chemotherapy. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 26, 2024 Category: Cancer & Oncology Source Type: research

Surgical site infections after glioblastoma surgery: boon or bane?
ConclusionOur data suggest that SSIs might reduce early recurrences without affecting overall survival. Furthermore, they might decrease health-related quality of life by doubling the total length of hospital stay. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 26, 2024 Category: Cancer & Oncology Source Type: research

Developing a clinical-radiomic prediction model for 3-year cancer-specific survival in lung cancer patients treated with stereotactic body radiation therapy
ConclusionA clinical-radiomic model was developed to predict the 3-year CSS for lung cancer patients treated with SBRT. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 26, 2024 Category: Cancer & Oncology Source Type: research

Prognosis and immunotherapy response prediction based on M2 macrophage-related genes in colon cancer
ConclusionA novel M2 macrophage-related gene signature affects the prognosis and immune characteristics of colon cancer. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 25, 2024 Category: Cancer & Oncology Source Type: research

Prediction of positive pulmonary nodules based on machine learning algorithm combined with central carbon metabolism data
ConclusionWe developed a series of predictive models for PPNs, which can help in the early detection of PPNs and thus reduce the risk of lung cancer. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 25, 2024 Category: Cancer & Oncology Source Type: research

Patient –physician communication about cancer-related fatigue: a survey of patient-perceived barriers
ConclusionThis study revealed gaps in the patient –physician communication regarding cancer-related fatigue. Contrary to guideline recommendations a minority of physicians addressed fatigue. On the other hand, cancer patients felt reluctant to bring up this topic due to structural barriers and fears. Physicians should routinely address fatigue an d adopt a communication style which encourages patients to likewise state their symptoms and raise their questions.Trial registrationClinicaltrials.gov, identifier: NCT04921644. Registered in June 2021. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 25, 2024 Category: Cancer & Oncology Source Type: research

The m6A demethylase FTO targets POLQ to promote ccRCC cell proliferation and genome stability maintenance
ConclusionFTO could potentially serve as a diagnostic marker for ccRCC. FTO promotes the progression of ccRCC by regulating m6A modification, making the inhibition of FTO a potential novel therapeutic strategy in ccRCC. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 25, 2024 Category: Cancer & Oncology Source Type: research

Early port site and peritoneal metastasis following robot-assisted radical cystectomy: a rare case report
AbstractRadical cystectomy with pelvic lymph node dissection is the recommended treatment for managing muscle-invasive carcinoma of the urinary bladder. Early recurrence is observed in only about 4.1% of cases. Port-site metastasis following robot-assisted radical cystectomy is extremely rare. We encountered a challenging and a rare case of bladder cancer that manifested with port-site and peritoneal metastasis within 6  weeks of surgery. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 25, 2024 Category: Cancer & Oncology Source Type: research

Human papillomavirus E7 protein induces homologous recombination defects and PARPi sensitivity
ConclusionIn aggregate, our findings demonstrate that HPV-E7 is a potential driver for genome instability and provides a new angle to understand its role in cancer development. The viral HRD could be employed to target HPV-positive cervical cancer via synthetic lethality. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 23, 2024 Category: Cancer & Oncology Source Type: research

The poor prognosis of lacrimal gland adenocarcinoma: a clinical study and literature review
ConclusionThe incidence of bone destruction and distant metastasis of lacrimal adenocarcinoma is high and the imaging examination is necessary to assess the risk of distant metastasis. The 5-year survival rate of death or metastasis is 33.5% and the high expression of Ki-67 predicts poor prognosis of lacrimal adenocarcinoma. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 23, 2024 Category: Cancer & Oncology Source Type: research

Expression analysis of lymphocyte subsets and lymphocyte-to-monocyte ratio: reveling immunosuppression and chronic inflammation in breast cancer
ConclusionLymphocyte subsets and LMR reflect the immune status and chronic inflammation of the body, respectively. They have certain value in the diagnosis of benign and malignant breast diseases, and correlate with lymph node metastasis, clinical staging, molecular typing and other clinicopathological features of breast cancer. Therefore, monitoring the expression of lymphocyte subsets and LMR in the body may help the auxiliary diagnosis and condition analysis of breast cancer in the clinic. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 23, 2024 Category: Cancer & Oncology Source Type: research

The effect of resistin on the redox state of breast cancer cells
ConclusionTaken together, the findings support resistin ’s role as a non-oxidative stress marker and a metabolic signaling molecule. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 22, 2024 Category: Cancer & Oncology Source Type: research

Prognostic value of preoperative circulating tumor DNA in non-small cell lung cancer: a systematic review and meta-analysis
ConclusionThe evaluation of the prognostic value of preoperative ctDNA revealed that preoperative ctDNA might be used as a prognostic biomarker for patients with LUAD or those with stage I –II NSCLC. In addition, postoperative AT is recommended for NSCLC patients with positive preoperative ctDNA, regardless of the disease stage and subtype. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - January 22, 2024 Category: Cancer & Oncology Source Type: research

Immunogenic profiling of metastatic uveal melanoma discerns a potential signature related to prognosis
AbstractBackgroundUveal melanoma (UM) is an aggressive intraocular malignant tumor. The present study aimed to identify the key genes associated with UM metastasis and established a gene signature to analyze the relationship between the signature and prognosis and immune cell infiltration. Later, a predictive model combined with clinical variables was developed and validated.MethodsTwo UM gene expression profile chip datasets were downloaded from TCGA and GEO databases. Immune-related genes (IRGs) were obtained from IMPORT database. First, these mRNAs were intersected with IRGs, and weighted gene co-expression network anal...
Source: Journal of Cancer Research and Clinical Oncology - January 21, 2024 Category: Cancer & Oncology Source Type: research