α‐Hederin induces paraptosis by targeting GPCRs to activate Ca2+/MAPK signaling pathway in colorectal cancer

ConclusionsCollectively, our findings proved α-hed as a promising candidate for inducing non-apoptotic cell death, paraptosis. It may overcome the resistance of apoptotic-based chemo-resistance in CRC.

Source: Cancer Medicine - April 25, 2024 Category: Cancer & Oncology Authors: Xiwu Rao, Ziwen Li, Qinchang Zhang, Yueyang Lai, Jianrong Liu, Liu Li, Haibo Cheng, Weixing Shen, Dongdong Sun Tags: RESEARCH ARTICLE Source Type: research