Cancers, Vol. 16, Pages 1369: Immunotherapy for Thymomas and Thymic Carcinomas: Current Status and Future Directions
Adams
Thymic epithelial tumors are a histologically diverse group of cancers arising from the epithelial compartment of the thymus. These tumors are characterized by a low tumor mutation burden, a lack of actionable genomic changes, and, especially with thymomas, defects in immune tolerance. Surgery is the mainstay of the management of resectable disease, whereas advanced, unresectable tumors are treated with platinum-based chemotherapy. Disease recurrence can occur months to years after frontline treatment. Although several options are available for conventional treatment of recurrent thymic tumors, response rates are...
Source: Cancers - March 30, 2024 Category: Cancer & Oncology Authors: Arun Rajan Alisa K. Sivapiromrat Meredith J. McAdams Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1370: Identification of Two Distinct Immune Subtypes in Hepatitis B Virus (HBV)-Associated Hepatocellular Carcinoma (HCC)
This study identifies two distinctive immune subtypes in HBV-associated HCC, regardless of the microenvironment observed in the surrounding nontumorous tissue, providing new insights into pathogenesis. These findings may be instrumental in the identification of patients who might benefit from immunotherapy. (Source: Cancers)
Source: Cancers - March 30, 2024 Category: Cancer & Oncology Authors: Davide De Battista Rylee Yakymi Evangeline Scheibe Shinya Sato Hannah Gerstein Tovah E. Markowitz Justin Lack Roberto Mereu Cristina Manieli Fausto Zamboni Patrizia Farci Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1371: Occurrence and Management of Immunotherapy-Associated Adverse Events in Patients with Gynecological Cancers
Conclusion: The broad spectrum of irAEs and the onset time of irAEs are important challenges of therapy with ICIs, requiring proactive monitoring and tailored management strategies to optimize the safety and efficacy of immunotherapy. (Source: Cancers)
Source: Cancers - March 30, 2024 Category: Cancer & Oncology Authors: Ina Shehaj Maria Schr öder Valerie Catherine Linz Slavomir Krajnak Katrin Almstedt Kathrin Stewen Roxana Schwab Annette Hasenburg Marcus Schmidt Anne-Sophie Heimes Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1372: The Impact of Radiofrequency Ablation on Survival Outcomes and Stent Patency in Patients with Unresectable Cholangiocarcinoma: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
arzioni
Luca Maroni
Endoluminal biliary radiofrequency ablation (RFA) has been proposed as a palliative treatment for patients with malignant biliary obstruction (MBO) in order to improve stent patency and survival. However, the existing data on patients with inoperable extrahepatic cholangiocarcinoma (eCCA) are conflicting. We performed a meta-analysis of randomized trials comparing RFA plus stenting versus stenting alone in patients with inoperable eCCA. We searched for trials published in the PubMed/MEDLINE, Scopus, and Cochrane databases up to November 2023. Data extraction was conducted from published studies, a...
Source: Cancers - March 30, 2024 Category: Cancer & Oncology Authors: Daniele Balducci Michele Montori Francesco Martini Marco Valvano Federico De Blasio Maria Eva Argenziano Giuseppe Tarantino Antonio Benedetti Emanuele Bendia Marco Marzioni Luca Maroni Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1358: Utility Scores for Risk-Reducing Mastectomy and Risk-Reducing Salpingo-Oophorectomy: Mapping to EQ-5D
Conclusions: We present the first HRUSs sourced from patients following RRM and RRSO. There is a need for high-quality prospective studies to characterise quality of life at different timepoints. (Source: Cancers)
Source: Cancers - March 30, 2024 Category: Cancer & Oncology Authors: Samuel G. Oxley Xia Wei Michail Sideris Oleg Blyuss Ashwin Kalra Jacqueline J. Y. Sia Subhasheenee Ganesan Caitlin T. Fierheller Li Sun Zia Sadique Haomiao Jin Ranjit Manchanda Rosa Legood Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1360: Enhanced Therapeutic Efficacy of the Nanoscale Fluoropyrimidine Polymer CF10 in a Rat Colorectal Cancer Liver Metastasis Model
H. Gmeiner
Combination chemotherapy regimens that include fluoropyrimidine (FP) drugs, e.g., 5-fluorouracil (5-FU), are central to the treatment of colorectal cancer liver metastases (CRLMs), a major cause of cancer mortality. We tested a second-generation FP polymer, CF10, in a CC531/WAGRij syngeneic orthotopic rat model of liver metastasis to determine if CF10 improved response relative to 5-FU. CF10 displayed increased potency relative to 5-FU in CC531 rat colorectal cancer cells based on clonogenic assay results and caused increased apoptosis, as shown using a live/dead assay. The increased potency of CF10 to CC53...
Source: Cancers - March 30, 2024 Category: Cancer & Oncology Authors: Charles Chidi Okechukwu Xue Ma Naresh Sah Chinnadurai Mani Komaraiah Palle William H. Gmeiner Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1359: Induction of Immunological Antitumor Effects by the Combination of Adenovirus-Mediated Gene Transfer of B7-1 and Anti-Programmed Cell Death-1 Antibody in a Murine Squamous Cell Carcinoma Model
Conclusions: These results suggest that the B7-1 gene transfer may enhance the antitumor effect of anti-PD1 antibody against SCC. (Source: Cancers)
Source: Cancers - March 30, 2024 Category: Cancer & Oncology Authors: Makiko Hara Sumiyo Saburi Natsumi Uehara Takahiro Tsujikawa Mie Kubo Tatsuya Furukawa Masanori Teshima Hirotaka Shinomiya Shigeru Hirano Ken-ichi Nibu Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1361: Zebrafish & mdash;A Suitable Model for Rapid Translation of Effective Therapies for Pediatric Cancers
Cancers, Vol. 16, Pages 1361: Zebrafish—A Suitable Model for Rapid Translation of Effective Therapies for Pediatric Cancers
Cancers doi: 10.3390/cancers16071361
Authors:
Debasish Roy
Bavani Subramaniam
Wai Chin Chong
Miriam Bornhorst
Roger J. Packer
Javad Nazarian
Pediatric cancers are the leading cause of disease-related deaths in children and adolescents. Most of these tumors are difficult to treat and have poor overall survival. Concerns have also been raised about drug toxicity and long-term detrimental side effects of therapies. In this review, we discuss the advantages and unique attribute...
Source: Cancers - March 30, 2024 Category: Cancer & Oncology Authors: Debasish Roy Bavani Subramaniam Wai Chin Chong Miriam Bornhorst Roger J. Packer Javad Nazarian Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1362: Breast Tumor Tissue Image Classification Using Single-Task Meta Learning with Auxiliary Network
Wu
Breast cancer has a high mortality rate among cancers. If the type of breast tumor can be correctly diagnosed at an early stage, the survival rate of the patients will be greatly improved. Considering the actual clinical needs, the classification model of breast pathology images needs to have the ability to make a correct classification, even in facing image data with different characteristics. The existing convolutional neural network (CNN)-based models for the classification of breast tumor pathology images lack the requisite generalization capability to maintain high accuracy when confronted with pathology image...
Source: Cancers - March 30, 2024 Category: Cancer & Oncology Authors: Jiann-Shu Lee Wen-Kai Wu Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1363: Biomarkers for Pre-Treatment Risk Stratification of Prostate Cancer Patients: A Systematic Review
Conclusion: This systematic review unveils the substantial clinical promise of using circulating biomarkers in assessing the risk for prostate cancer patients. However, the standardization of groups, categories, and biomarker validation are mandatory before this technique can be implemented. Circulating biomarkers might represent a viable alternative to currently available tools, obviating the need for tissue biopsies, and allowing for faster and more cost-effective testing, with superior analytical performance, specificity, and reproducibility. (Source: Cancers)
Source: Cancers - March 30, 2024 Category: Cancer & Oncology Authors: Jos é Pedro Sequeira Sofia Salta Rui Freitas Rafael L ópez-López Ángel Díaz-Lagares Rui Henrique Carmen Jer ónimo Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1364: Prediction of Response to Anti-Angiogenic Treatment for Advanced Colorectal Cancer Patients: From Biological Factors to Functional Imaging
ceddu
Marco Puzzoni
Cinzia Solinas
Elena Massa
Clelia Madeddu
Clara Gerosa
Luigi Zorcolo
Gavino Faa
Luca Saba
Mario Scartozzi
Colorectal cancer (CRC) is a leading tumor worldwide. In CRC, the angiogenic pathway plays a crucial role in cancer development and the process of metastasis. Thus, anti-angiogenic drugs represent a milestone for metastatic CRC (mCRC) treatment and lead to significant improvement of clinical outcomes. Nevertheless, not all patients respond to treatment and some develop resistance. Therefore, the identification of predictive factors able to predict response to angiogenesis pathw...
Source: Cancers - March 30, 2024 Category: Cancer & Oncology Authors: Giuseppe Corrias Eleonora Lai Pina Ziranu Stefano Mariani Clelia Donisi Nicole Liscia Giorgio Saba Andrea Pretta Mara Persano Daniela Fanni Dario Spanu Francesca Balconi Francesco Loi Simona Deidda Angelo Restivo Valeria Pusceddu Marco Puzzoni Cinzia Soli Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1365: Improved Metastatic-Free Survival after Systematic Re-Excision Following Complete Macroscopic Unplanned Excision of Limb or Trunk Soft Tissue Sarcoma
Conclusions: RE might be considered in patients with STS of limb or trunk, with UE with macroscopic complete resection performed out of a reference center, and also in originally defined R0 margin resections, to improve LRFS and MFS. Systematic RE should not be advocated for patients older than 70 years, or with tumors greater than 10 cm. (Source: Cancers)
Source: Cancers - March 30, 2024 Category: Cancer & Oncology Authors: Francois Gouin Audrey Michot Mehrdad Jafari Charles Honor é Jean Camille Mattei Alexandre Rochwerger Mickael Ropars Dimitri Tzanis Philippe Anract S ébastien Carrere Dimitri Gangloff Agn ès Ducoulombier C éleste Lebbe J érôme Guiramand Denis Waast F Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1366: Revolutionizing Treatment: Breakthrough Approaches for BCG-Unresponsive Non-Muscle-Invasive Bladder Cancer
utwin
Bladder cancer is the 10th most popular cancer in the world, and non-muscle-invasive bladder cancer (NMIBC) is diagnosed in ~80% of all cases. Treatments for NMIBC include transurethral resection of the bladder tumor (TURBT) and intravesical instillations of Bacillus Calmette-Guérin (BCG). Treatment of BCG-unresponsive tumors is scarce and usually leads to Radical Cystectomy. In this paper, we review recent advancements in conservative treatment of BCG-unresponsive tumors. The main focus of the paper is FDA-approved medications: Pembrolizumab and Nadofaragene Firadenovec (Adstiladrin). Other, less ...
Source: Cancers - March 30, 2024 Category: Cancer & Oncology Authors: Maciej Jaromin Tomasz Konecki Piotr Kutwin Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1367: The Effect of Exercise on Reducing Lymphedema Severity in Breast Cancer Survivors
a Gupta
Exercise has been repeatedly shown to be safe and beneficial for cancer survivors. However, there is no normative guideline for exercise prescription, and it is still under exploration. Therefore, this literature review aims to provide some advice for the formulation of exercise prescriptions for patients with breast cancer-related lymphedema (BCRL) from the perspective of reducing lymphedema severity. A review of relevant studies published before November 2023 was conducted using three scientific databases: PubMed, Embase, and Scopus. A total of 2696 articles were found. Eventually, 13 studies fulfilled the in...
Source: Cancers - March 30, 2024 Category: Cancer & Oncology Authors: Yanxue Lian Simran Sandhu Yamikani Asefa Ananya Gupta Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1341: Cervical Cancer Associated with Pregnancy: Current Challenges and Future Strategies
n Kissel
Cancer during pregnancy is defined as a tumor diagnosed in a pregnant woman or up to 1-year post-partum. While being a rare disease, cervical cancer is probably one of the most challenging medical conditions, with the dual stake of treating the cancer without compromising its chances for cure, while preserving the pregnancy and the health of the fetus and child. To date, guidelines for gynecological cancers are provided through international consensus meetings with expert panels, giving insights on both diagnosis, treatment, and obstetrical care. However, these expert guidelines do not discuss the various appr...
Source: Cancers - March 29, 2024 Category: Cancer & Oncology Authors: Jennifer Le Gu évelou Lise Selleret Enora Laas Fabrice Lecuru Manon Kissel Tags: Systematic Review Source Type: research
