Cancers, Vol. 16, Pages 1445: Impact of Indoor Radon Exposure on Lung Cancer Incidence in Slovenia
Vesna Zadnik
Indoor radon is an important risk factor for lung cancer, as 3–14% of lung cancer cases can be attributed to radon. The aim of our study was to estimate the impact of indoor radon exposure on lung cancer incidence over the last 40 years in Slovenia. We analyzed the distribution of lung cancer incidence across 212 municipalities and 6032 settlements in Slovenia. The standardized incidence ratios were smoothed with the Besag–York–Mollie model and fitted with the integrated nested Laplace approximation. A categorical explanatory variable, the risk of indoor radon ex...
Source: Cancers - April 9, 2024 Category: Cancer & Oncology Authors: Mojca Birk Tina Žagar Sonja Tom šič Katarina Lokar Ana Mihor Nika Bric Miran Mlakar Vesna Zadnik Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1446: Ovarian Causes of Pseudomyxoma Peritonei (PMP) & mdash;A Literature Review
Conclusions. In our study, we aimed to provide a comprehensive overview of the ovarian causes of pseudomyxoma peritonei, including its epidemiology, imagery characteristics, symptoms, current treatment, and promising future therapies, in the hopes of finding feasible solutions, as a lack of understanding of this mucus-secreting malignant disease increases the risk of delayed diagnosis or uncontrolled deterioration. (Source: Cancers)
Source: Cancers - April 9, 2024 Category: Cancer & Oncology Authors: Sinziana Ionescu Marian Marincas Octavia Luciana Madge Irinel Gabriel Dicu-Andreescu Elena Chitoran Vlad Rotaru Ciprian Cirimbei Mirela Gherghe Adina Ene Robert Rosca Madalina Radu Laurentiu Simion Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1438: Correction: Soda et al. Electrochemical Detection of Global DNA Methylation Using Biologically Assembled Polymer Beads. Cancers 2021, 13, 3787
mmad J. A. Shiddiky
In the original publication [...] (Source: Cancers)
Source: Cancers - April 8, 2024 Category: Cancer & Oncology Authors: Narshone Soda Zennia Jean Gonzaga Amandeep Singh Pannu Navid Kashaninejad Richard Kline Carlos Salomon Nam-Trung Nguyen Prashant Sonar Bernd H. A. Rehm Muhammad J. A. Shiddiky Tags: Correction Source Type: research
Cancers, Vol. 16, Pages 1440: Immune-Related Adverse Events Due to Cancer Immunotherapy: Immune Mechanisms and Clinical Manifestations
In conclusion, considering the escalating use of ICIs, this area of research necessitates additional clinical studies and practical insights, especially the development of biomarkers for predicting immune toxicities. In addition, there is a need for heightened education for both clinicians and patients to enhance understanding and awareness. (Source: Cancers)
Source: Cancers - April 8, 2024 Category: Cancer & Oncology Authors: Silvia Casagrande Giulia Boscato Sopetto Giovanni Bertalot Roberto Bortolotti Vito Racanelli Orazio Caffo Bruno Giometto Alvise Berti Antonello Veccia Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1439: Simultaneous Visualization of Lung Tumor and Intersegmental Plane during Pulmonary Segmentectomy by Intravenous Injection of Indocyanine Green
This study is the first to use intravenous ICG injections at different time points and doses to simultaneously detect lung cancer and intersegmental planes, thereby achieving segmentectomy for lung cancer. (Source: Cancers)
Source: Cancers - April 8, 2024 Category: Cancer & Oncology Authors: Kyungsu Kim Ok Hwa Jeon Byeong Hyeon Choi Jiyun Rho Jun Hee Lee Jae Seon Eo Beop-Min Kim Hyun Koo Kim Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1441: Pathological Insights: Enhanced Vision Transformers for the Early Detection of Colorectal Cancer
Choe
Endoscopic pathological findings of the gastrointestinal tract are crucial for the early diagnosis of colorectal cancer (CRC). Previous deep learning works, aimed at improving CRC detection performance and reducing subjective analysis errors, are limited to polyp segmentation. Pathological findings were not considered and only convolutional neural networks (CNNs), which are not able to handle global image feature information, were utilized. This work introduces a novel vision transformer (ViT)-based approach for early CRC detection. The core components of the proposed approach are ViTCol, a boosted vision transfo...
Source: Cancers - April 8, 2024 Category: Cancer & Oncology Authors: Gelan Ayana Hika Barki Se-woon Choe Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1442: Efficacy and Safety of Tinzaparin Thromboprophylaxis in Lung Cancer Patients with High Thromboembolic Risk: A Prospective, Observational, Single-Center Cohort Study
Conclusion: Thromboprophylaxis with an intermediate Tinzaparin dose in high thrombotic-risk lung cancer patients is a safe and effective choice for the prevention of VTE. (Source: Cancers)
Source: Cancers - April 8, 2024 Category: Cancer & Oncology Authors: Marousa Kouvela Maria Effrosyni Livanou Dimitra T. Stefanou Ioannis A. Vathiotis Fotini Sarropoulou Maria Grammoustianou Evangelos Dimakakos Nikolaos Syrigos Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1443: Performance of Commercial Dermatoscopic Systems That Incorporate Artificial Intelligence for the Identification of Melanoma in General Practice: A Systematic Review
Conclusion: Instead of focusing on the performance of AI versus clinicians for classifying melanoma, more consistent performance has been obtained when clinicians’ work is supported by AI, facilitating management decisions and improving health outcomes. (Source: Cancers)
Source: Cancers - April 8, 2024 Category: Cancer & Oncology Authors: Ian Miller Nedeljka Rosic Michael Stapelberg Jeremy Hudson Paul Coxon James Furness Joe Walsh Mike Climstein Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1444: scRNAseq and High-Throughput Spatial Analysis of Tumor and Normal Microenvironment in Solid Tumors Reveal a Possible Origin of Circulating Tumor Hybrid Cells
This study establishes a framework for HC identification in large datasets, providing compelling evidence for their tissue residence and offering comprehensive transcriptomic characterization. Furthermore, it sheds light on their differential function and identifies pathways that could explain their newly acquired invasive capabilities. THCs should be considered as potential therapeutic targets. (Source: Cancers)
Source: Cancers - April 8, 2024 Category: Cancer & Oncology Authors: Abdullah Mahmood Ali Azra Raza Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1435: The Exacerbating Effects of the Tumor Necrosis Factor in Cardiovascular Stenosis: Intimal Hyperplasia
ela
TNF-a functions as a master regulator of inflammation, and it plays a prominent role in several immunological diseases. By promoting important cellular mechanisms, such as cell proliferation, migration, and phenotype switch, TNF-a induces its exacerbating effects, which are the underlying cause of many proliferative diseases such as cancer and cardiovascular disease. TNF-a primarily alters the immune component of the disease, which subsequently affects normal functioning of the cells. Monoclonal antibodies and synthetic drugs that can target TNF-a and impair its effects have been developed and are currently used in...
Source: Cancers - April 8, 2024 Category: Cancer & Oncology Authors: Chandra Shekhar Boosani Laxminarayana Burela Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1436: Exploring The Prognostic Significance of SET-Domain Containing 2 (SETD2) Expression in Advanced and Castrate-Resistant Prostate Cancer
Tarek A. Bismar
SET-domain containing 2 (SETD2) is a histone methyltransferase and an epigenetic modifier with oncogenic functionality. In the current study, we investigated the potential prognostic role of SETD2 in prostate cancer. A cohort of 202 patients’ samples was assembled on tissue microarrays (TMAs) containing incidental, advanced, and castrate-resistant CRPCa cases. Our data showed significant elevated SETD2 expression in advanced and castrate-resistant disease (CRPCa) compared to incidental cases (2.53 ± 0.58 and 2.21 ± 0.63 vs. 1.9 ± 0.68; p &am...
Source: Cancers - April 8, 2024 Category: Cancer & Oncology Authors: Yaser Gamallat Joema Felipe Lima Sima Seyedi Qiaowang Li Jon George Rokne Reda Alhajj Sunita Ghosh Tarek A. Bismar Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1437: Clinical [18F]FSPG Positron Emission Tomography Imaging Reveals Heterogeneity in Tumor-Associated System xc & minus; Activity
Conclusion: [18F]FSPG PET/CT imaging from both NSCLC and HNSCC cohorts showed the same normal-tissue biodistribution, but marked tumor heterogeneity across subjects and between lesions. Despite rapid elimination through the urinary tract and low normal-background tissue retention, the diagnostic potential of [18F]FSPG was limited by variability in tumor retention. As [18F]FSPG retention is mediated by the tumor’s antioxidant capacity and response to oxidative stress, this heterogeneity may provide important insights into an individual tumor’s response or resistance to therapy. (Source: Cancers)
Source: Cancers - April 8, 2024 Category: Cancer & Oncology Authors: Amy R. Sharkey Norman Koglin Erik S. Mittra Sangwon Han Gary J. R. Cook Timothy H. Witney Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1424: MRI & ndash;Ultrasound Fused Approach for Prostate Biopsy & mdash;How It Is Performed
Cancers, Vol. 16, Pages 1424: MRI–Ultrasound Fused Approach for Prostate Biopsy—How It Is Performed
Cancers doi: 10.3390/cancers16071424
Authors:
Jacob Lang
Timothy Dale McClure
Daniel J. A. Margolis
The use of MRI–ultrasound image fusion targeted biopsy of the prostate in the face of an elevated serum PSA is now recommended by multiple societies, and results in improved detection of clinically significant cancer and, potentially, decreased detection of indolent disease. This combines the excellent sensitivity of MRI for clinically significant prostate cancer and the real-time ...
Source: Cancers - April 7, 2024 Category: Cancer & Oncology Authors: Jacob Lang Timothy Dale McClure Daniel J. A. Margolis Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1425: The Impact of Adjunct Medical Therapy on Survival after Spine Metastasis: A Systematic Review and Pooled Data Analysis
This study represents the first comprehensive systematic review that encompasses the most common primary cancers that metastasize to the spine and evaluates the median overall survival (mOS) across five different medical treatment modalities as well as surgical intervention. Additionally, our study analyzes the tumor receptor status in conjunction with these treatments. A PubMed search was conducted, and according to the PRISMA guidelines, 28 articles out of 1834 met the inclusion criteria. The pooled data analysis highlighted the superior efficacy of targeted therapy, evidenced by a significant improvement in the mOS and ...
Source: Cancers - April 7, 2024 Category: Cancer & Oncology Authors: Lilly Groszman Jonathan A. Hubermann Paul Kooner Nawaf Alamiri Anthony Bozzo Ahmed Aoude Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1427: Prognostic Indicators of Overall Survival in Hepatocellular Carcinoma Patients Undergoing Liver Resection
Hajjar
Florin Graur
Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer and the third contributor to malignancy-related deaths worldwide. The hepatic venous pressure gradient (HVPG), transient elastography-liver stiffness measurement (TE-LSM), and the association between TBS (tumor burden score), alpha-fetoprotein levels, and the Child–Pugh classification (TAC score) can serve as valuable prognostic indicators for these patients. Therefore, the main objective of our research was to analyze the prognostic value of the HVPG, TE-LSM, TBS, and TAC scores. An observational and sur...
Source: Cancers - April 7, 2024 Category: Cancer & Oncology Authors: Cristina-Paula Ursu Andra Ciocan Ștefan Ursu R ăzvan Alexandru Ciocan Claudia Diana Gherman Ariana-Anamaria Cordo ș Dan V ălean Rodica Sorina Pop Lumini ța Elena Furcea Bogdan Procope ț Horia Ștefănescu Emil Ioan Moi ș Nadim Al Hajjar Florin Grau Tags: Article Source Type: research
