Cancers, Vol. 16, Pages 1286: Uniportal Video-Assisted Thoracoscopic Surgery Completion Lobectomy Long after Wedge Resection or Segmentectomy in the Same Lobe: A Bicenter Study
Conclusions: U-VATS CL seems feasible and safe after wedge resection and anatomical segmentectomy. (Source: Cancers)
Source: Cancers - March 26, 2024 Category: Cancer & Oncology Authors: Elisa Meacci Majed Refai Dania Nachira Michele Salati Khrystyna Kuzmych Diomira Tabacco Edoardo Zanfrini Giuseppe Calabrese Antonio Giulio Napolitano Maria Teresa Congedo Marco Chiappetta Leonardo Petracca-Ciavarella Carolina Sassorossi Marco Andolfi Fran Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1287: Ianus Bifrons: The Two Faces of Metformin
Albertelli
The ancient Roman god Ianus was a mysterious divinity with two opposite faces, one looking at the past and the other looking to the future. Likewise, metformin is an “old” drug, with one side looking at the metabolic role and the other looking at the anti-proliferative mechanism; therefore, it represents a typical and ideal bridge between diabetes and cancer. Metformin (1,1-dimethylbiguanidine hydrochloride) is a drug that has long been in use for the treatment of type 2 diabetes mellitus, but recently evidence is growing about its potential use in other metabolic conditions and...
Source: Cancers - March 26, 2024 Category: Cancer & Oncology Authors: Goglia Hasballa Teti Boschetti Ferone Albertelli Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1288: Asciminib Maintains Antibody-Dependent Cellular Cytotoxicity against Leukemic Blasts
Märklin
B cell acute lymphoblastic leukemia (B-ALL) is characterized by an accumulation of malignant precursor cells. Treatment consists of multiagent chemotherapy followed by allogeneic stem cell transplantation in high-risk patients. In addition, patients bearing the BCR-ABL1 fusion gene receive concomitant tyrosine kinase inhibitor (TKI) therapy. On the other hand, monoclonal antibody therapy is increasingly used in both clinical trials and real-world settings. The introduction of rituximab has improved the outcomes in CD20 positive cases. Other monoclonal antibodies, such as tafasitamab (anti-CD19), obinutuzumab (...
Source: Cancers - March 26, 2024 Category: Cancer & Oncology Authors: Samuel J. Holzmayer Joseph Kauer Jonas Mauermann Tobias Roider Melanie M ärklin Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1290: Innovative Combinations, Cellular Therapies and Bispecific Antibodies for Chronic Lymphocytic Leukemia: A Narrative Review
iarenza
In the last few years, several agents targeting molecules that sustain the survival and the proliferation of chronic lymphocytic leukemia (CLL) cells have become clinically available. Most of these drugs target surface proteins, such as CD19 or CD20, via monoclonal or bispecific monoclonal antibodies (BsAbs), CAR T cells, intracellular proteins like BTK by using covalent or non-covalent inhibitors or BCL2 with first or second generation BH3-mimetics. Since the management of CLL is evolving quickly, in this review we highlighted the most important innovative treatments including novel double and triple combinati...
Source: Cancers - March 26, 2024 Category: Cancer & Oncology Authors: Andrea Visentin Sara Frazzetto Livio Trentin Annalisa Chiarenza Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1289: An MRI Radiomics Approach to Predict the Hypercoagulable Status of Gliomas
ne Galmiche
Venous thromboembolic events are frequent complications of Glioblastoma Multiforme (GBM) and low-grade gliomas (LGGs). The overexpression of tissue factor (TF) plays an essential role in the local hypercoagulable phenotype that underlies these complications. Our aim was to build an MRI radiomics model for the non-invasive exploration of the hypercoagulable status of LGG/GBM. Radiogenomics data from The Cancer Genome Atlas (TCGA) and REMBRANDT (Repository for molecular BRAin Neoplasia DaTa) cohorts were used. A logistic regression model (Radscore) was built in order to identify the top 20% TF-expressing tumo...
Source: Cancers - March 26, 2024 Category: Cancer & Oncology Authors: Zuzana Saidak Adrien Laville Simon Soudet Marie-Antoinette Sevestre Jean-Marc Constans Antoine Galmiche Tags: Article Source Type: research
