Cancers, Vol. 16, Pages 1204: Immunoprofiles and Oncologic Outcomes of 15 Patients with Androgen Receptor-Positive Salivary Duct Carcinoma
Conclusion: Despite only including AR+ SDC of the parotid, immunoprofiles, such as expression of HER-2, were highly variable, highlighting the potential to tailor systemic regimens based on individual histologic profiles in the future. Studies with larger patient numbers using tumor-specific molecular profiling and tumor heterogeneity analyses are justified to better understand the biology of these tumors. Molecularly informed treatment approaches, including the potential use of AR- and HER-2/Neu-directed therapies upfront in the definitive setting, may hold future promise to further improve outcomes for these patients. (Source: Cancers)
Source: Cancers - March 19, 2024 Category: Cancer & Oncology Authors: Emile Gogineni Blake E. Sells Khaled Dibs Sachin R. Jhawar Catherine T. Haring Abberly L. Limbach David J. Konieczkowski Sung J. Ma Simeng Zhu Sujith Baliga Darrion L. Mitchell John C. Grecula Marcelo Bonomi Priyanka Bhateja Matthew O. Old Nolan B. Seim S Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1205: Exploring Immunological Effects and Novel Immune Adjuvants in Immunotherapy for Salivary Gland Cancers
Miki Takahara Salivary gland cancer (SGC) is rare and comprises over 20 histological subtypes. Recently, clinical experience regarding immunotherapies for SGCs has been accumulating, yet their efficacy remains controversial. Understanding the tumor microenvironment (TME), including the expression of immune checkpoint molecules in SGC, is crucial to optimizing immunotherapy. In this review, we demonstrate that high-grade mucoepidermoid carcinoma and salivary duct carcinoma generally exhibit immune-hot TME with high immune cell infiltration, frequent genetic mutations, and robust immune checkpoint molecule expression. In...
Source: Cancers - March 19, 2024 Category: Cancer & Oncology Authors: Ryosuke Sato Hidekiyo Yamaki Hiroki Komatsuda Risa Wakisaka Takahiro Inoue Takumi Kumai Miki Takahara Tags: Review Source Type: research

Cancers, Vol. 16, Pages 1206: Adaptive Radiotherapy: Next-Generation Radiotherapy
dan Zheng Radiotherapy, a crucial technique in cancer therapy, has traditionally relied on the premise of largely unchanging patient anatomy during the treatment course and encompassing uncertainties by target margins. This review introduces adaptive radiotherapy (ART), a notable innovation that addresses anatomy changes and optimizes the therapeutic ratio. ART utilizes advanced imaging techniques such as CT, MRI, and PET to modify the treatment plan based on observed anatomical changes and even biological changes during the course of treatment. The narrative review provides a comprehensive guide on ART for healthcare ...
Source: Cancers - March 19, 2024 Category: Cancer & Oncology Authors: Olga Maria Dona Lemus Minsong Cao Bin Cai Michael Cummings Dandan Zheng Tags: Review Source Type: research

Cancers, Vol. 16, Pages 1207: Robot-Assisted Radical Prostatectomy by the Hugo Robotic-Assisted Surgery (RAS) System and the da Vinci System: A Comparison between the Two Platforms
Conclusion: During the process of adaptation, although intricate motions (such as the vesicourethral anastomosis time) would be lengthened, the overall console time would not change remarkably. In this process, the functional and oncological outcomes would not be compromised. This encourages urologists to adopt the Hugo RAS system in RARP if they have previous experiences of using the DV system, since their trifecta advantage would not be compromised. (Source: Cancers)
Source: Cancers - March 19, 2024 Category: Cancer & Oncology Authors: Hsien-Che Ou Lucian Marian Ching-Chia Li Yung-Shun Juan Min-Che Tung Hung-Jen Shih Chin-Po Chang Jian-Ting Chen Che-Hsueh Yang Yen-Chuan Ou Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1209: Current Treatment Options for Renal Cell Carcinoma: Focus on Cell-Based Immunotherapy
aire Roddie Renal cell carcinoma (RCC) affects over 400,000 patients globally each year, and 30% of patients present with metastatic disease. Current standard of care therapy for metastatic RCC involve TKIs and ICIs, including combinatorial strategies, but this offers only modest clinical benefit. Novel treatment approaches are warranted, and cell-based immunotherapies for RCC hold significant promise. These are currently being tested in the pre-clinical setting and in early phase clinical trials. Here, we review the landscape of cellular immunotherapy for RCC in the context of currently available therapies, with a par...
Source: Cancers - March 19, 2024 Category: Cancer & Oncology Authors: Angela Hwang Vedika Mehra Jyoti Chhetri Samira Ali Maxine Tran Claire Roddie Tags: Review Source Type: research

Cancers, Vol. 16, Pages 1208: Cumulative Dosage of Intrathecal Chemotherapy Agents Predicts White Matter Integrity in Long-Term Survivors of Acute Lymphoblastic Leukemia: A PETALE Study
This study pursues two objectives. Firstly, it investigates if Magnetization Transfer Ratio (MTR), a method assessing myelin integrity, is sensitive to white matter (WM) microstructural changes in long-term ALL survivors and whether these relate to cognitive impairments. Secondly, it examines the dose-related effects of chemotherapy agents on the MTR and its relationship to other risk factors such as female sex, early age diagnosis, and cranial radiotherapy. Magnetization transfer imaging was utilized to assess WM integrity in 35 survivors at a mean of 18.9 years after the onset of ALL (range since diagnosis: 6.9&n...
Source: Cancers - March 19, 2024 Category: Cancer & Oncology Authors: Julie Laniel Serge Sultan Daniel Sinnett Caroline Laverdi ère Maja Krajinovic Philippe Robaey Luc Duong Sarah Lipp é Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1210: Clinical Workflow of Cone Beam Computer Tomography-Based Daily Online Adaptive Radiotherapy with Offline Magnetic Resonance Guidance: The Modular Adaptive Radiotherapy System (MARS)
Conclusion: This study describes the first workflow to date of a CBCT-based oART combined with a shuttle-based offline approach for MR guidance. The oART duration times reported resemble the range shown by previous publications for first clinical experiences with the Ethos system. (Source: Cancers)
Source: Cancers - March 19, 2024 Category: Cancer & Oncology Authors: Ji-Young Kim Bouchra Tawk Maximilian Knoll Philipp Hoegen-Sa ßmannshausen Jakob Liermann Peter E. Huber Mona Lifferth Clemens Lang Peter H äring Regula Gnirs Oliver J äkel Heinz-Peter Schlemmer J ürgen Debus Juliane H örner-Rieber Fabian Weykamp Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1198: Does Breast Surgery Type Alter Incidental Axillary Irradiation? A Dosimetric Analysis of the & ldquo;Sentinel Envahi et Randomisation du Curage & rdquo; SERC Trial
Conclusions. On the Berg level 1, PMRT gives a dose at least equivalent to the one given by post-breast-conserving surgery radiotherapy, making it possible to limit completion axillary lymph node dissections in select pN1a patients treated with a mastectomy. Modern radiotherapy techniques like VMAT tend to increase this incidental dose. (Source: Cancers)
Source: Cancers - March 19, 2024 Category: Cancer & Oncology Authors: Camille Nicolas Claire Petit Agn ès Tallet Jean-Marie Boher Leonel Varela Cagetti Veronique Favrel Laurence Gonzague Casabianca Morgan Guenole Hugues Mailleux Julien Darreon Marie Bannier Monique Cohen Laura Sabiani Camille Tallet Charlene Teyssandier An Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1199: Machine Learning Analysis of Post-Operative Tumour Progression in Non-Functioning Pituitary Neuroendocrine Tumours: A Pilot Study
In conclusion, this study demonstrates the potential of ML models in predicting post-operative outcomes for patients with NF PitNET. Future work should look to include additional, more granular, multicentre data, including incorporating imaging and operative video data. (Source: Cancers)
Source: Cancers - March 19, 2024 Category: Cancer & Oncology Authors: Ziad Hussein Robert W. Slack Stephanie E. Baldeweg Evangelos B. Mazomenos Hani J. Marcus Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1200: Accuracy of Frozen Section Biopsy in the Diagnosis of Endometrial Cancer: A Systematic Review and Meta-Analysis
mistoklis Dagklis The early and accurate diagnosis of endometrial cancer is of paramount importance for the survival of these patients. The aim of this study was to systematically appraise the available data regarding the accuracy of frozen section biopsy in diagnosing endometrial cancer. A thorough literature search was performed in PubMed/Medline, Scopus and the Cochrane Central Register of Controlled Trials databases from inception up to January 2023, with the use of specific, relevant key terms. A quality evaluation for each study was performed with the QUADAS-2 tool, whereas a bivariate random-effect model was per...
Source: Cancers - March 19, 2024 Category: Cancer & Oncology Authors: Stergios Kopatsaris Aikaterini Apostolopoulou Ioannis Tsakiridis Antigoni Tranidou Fotios Zachomitros Evangelos Papanikolaou Alexandros Daponte Ioannis Kalogiannidis Themistoklis Dagklis Tags: Systematic Review Source Type: research

Cancers, Vol. 16, Pages 1197: Harnessing ctDNA in Advanced Melanoma: A Promising Tool for Informed Clinical Decisions
s Urbonas Cutaneous melanoma, an aggressive malignancy, has undergone significant transformation in clinical management with the introduction of immune checkpoint inhibitors (ICIs) and targeted therapies. Current monitoring methods, such as imaging scans, present limitations, prompting exploration of alternative biomarkers. This review comprehensively explores the role of circulating tumor DNA (ctDNA) in advanced melanoma, covering technical aspects, detection methods, and its prognostic and predictive value. Recent findings underscore ctDNA’s potential applications and implications in clinical practice. ...
Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Rugile Pikturniene Alvydas Cesas Sonata Jarmalaite Arturas Razbadauskas Vincas Urbonas Tags: Systematic Review Source Type: research

Cancers, Vol. 16, Pages 1186: Natural Killer Cell Dysfunction in Premenopausal BRCA1 Mutation Carriers: A Potential Mechanism for Ovarian Carcinogenesis
Conclusions: Phase-specific differential NK cell activity in BRCA1 mutation carriers, either systemically or locally, may favor site-specific pre-invasive carcinogenesis. These cumulative effects across a reproductive lifecycle in high-risk carriers can have a detrimental effect further supporting epidemiological evidence for ovulation inhibition. (Source: Cancers)
Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Shaun Haran Kantaraja Chindera May Sabry Nafisa Wilkinson Rupali Arora Agnieszka Zubiak Thomas E. Bartlett Iona Evans Allison Jones Daniel Reisel Chiara Herzog Twana Alkasalias Mark Newman Jaeyeon Kim Angelique Fl öter Rådestad Kristina Gemzell-Danielss Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1185: EMT Dynamics in Lymph Node Metastasis of Oral Squamous Cell Carcinoma
Conclusion: Our findings demonstrate that EMT marker expression correlates with lymph node metastasis in OSCC. Developing therapies targeting regulators such as N-cadherin may prevent metastasis and improve outcomes. (Source: Cancers)
Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Yasmine Ghantous Shiraz Mozalbat Aysar Nashef Murad Abdol-Elraziq Shiran Sudri Shareef Araidy Hagar Tadmor Imad Abu El-naaj Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1187: Exercise Suppresses Head and Neck Squamous Cell Carcinoma Growth via Oncostatin M
hihata Akihide Tanimoto Major advances have been made in cancer treatment, but the prognosis for elderly cancer patients with sarcopenia and frailty remains poor. Myokines, which are thought to exert preventive effects against sarcopenia, have been reported to be associated with the prognosis of various cancers, but their effect on head and neck squamous cell carcinoma (HNSCC) is unknown. The aim of this study was to clarify the influence of exercise on the control of HNSCC and to examine the underlying mechanism involved. Mice were injected with HSC-3-M3 cells, a human cell line of highly metastatic and poorly diffe...
Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Takuya Yoshimura Yuka Hirano Taiji Hamada Seiya Yokoyama Hajime Suzuki Hirotaka Takayama Hirono Migita Takayuki Ishida Yasunori Nakamura Masahiro Ohsawa Akihiro Asakawa Kiyohide Ishihata Akihide Tanimoto Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1188: Investigating the Efficacy of EGFR-TKIs and Anti-VEGFR Combination in Advanced Non-Small Cell Lung Cancer: A Meta-Analysis
Conclusions: Our meta-analysis indicated EGFR-TKIs with anti-VEGFR in combination not only improved overall PFS but also showed similar results to a first line and first-generation agent compared to EGFR-TKI alone. (Source: Cancers)
Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Prashant Sakharkar Sonali Kurup Subrata Deb Kaitlin Assaad Dayna Gesinski Erysa J. Gayle Tags: Systematic Review Source Type: research