Cancers, Vol. 16, Pages 1267: Anti-Proliferative Effects of Lidocaine as an Autophagy Inducer in Bladder Cancer via Intravesical Instillation: In Vitro and Xenograft Mouse Model Experiments
young Hwa Kim Lidocaine exerts potential anti-tumor effects on various cancer cell lines, and its intravesical instillation is considered safer than intravenous administration for bladder cancer. However, the mechanisms underlying its anti-tumor effects have not been fully elucidated. Here, we aimed to elucidate the anti-tumor molecular mechanisms of lidocaine in bladder cancer cells and a xenograft model to substantiate the efficacy of its intravesical administration. We investigated the anti-proliferative and autophagyinducing activities of lidocaine in Nara Bladder Tumor No. 2 (NBT-II) rat bladder carcinoma cells us...
Source: Cancers - March 24, 2024 Category: Cancer & Oncology Authors: Young Chul Yoo Na-Young Kim Seokyung Shin Yunil Yang Ji Hae Jun Ju Eun Oh Myoung Hwa Kim Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1268: Racial Differences in the Detection Rate of Bladder Cancer Using Blue Light Cystoscopy: Insights from a Multicenter Registry
rk D. Tyson Yair Lotan Siamak Daneshmand the Blue Light Cystoscopy with Cysview Registry Group the Blue Light Cystoscopy with Cysview Registry Group The use of blue light cystoscopy (BLC) has been shown to improve bladder tumor detection. However, data demonstrating the efficacy of BLC across different races are limited. Herein, we aim to evaluate heterogeneity in the characteristics of BLC for the detection of malignant lesions among various races. Clinicopathologic information was collected from patients enrolled in the multi-institutional Cysview® registry (2014–2021) who underwent tr...
Source: Cancers - March 24, 2024 Category: Cancer & Oncology Authors: Seyedeh-Sanam Ladi-Seyedian Alireza Ghoreifi Badrinath Konety Kamal Pohar Jeffrey M. Holzbeierlein John Taylor Max Kates Brian Willard Jennifer M. Taylor Joseph C. Liao Hristos Z. Kaimakliotis Sima P. Porten Gary D. Steinberg Mark D. Tyson Yair Lotan Siam Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1269: Sperm-Associated Antigen 5 Knockout Reduces Doxorubicin and Docetaxel Resistance in Triple-Negative Breast Cancer MDA-MB-231 and BT549 Cells
In conclusion, recombinant plasmid-based CRISPR-Cas9 technology can be used to delete the SPAG5 gene in the TNBC cell lines. SPAG5 has an important role in regulating cell proliferation and doxorubicin- and docetaxel-resistance in MDA-MB-231 and BT549 cells. (Source: Cancers)
Source: Cancers - March 24, 2024 Category: Cancer & Oncology Authors: Ji He Jiawei Li Yanbiao Liu Yan Li Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1263: IL1B Polymorphism (rs1143634) and IL-1 & beta; Plasma Concentration as Predictors of Nutritional Disorders and Prognostic Factors in Multiple Myeloma Patients
Conclusions: Determination of the IL1B SNP (rs1143634) and plasma concentration of IL-1β may be useful in the assessment of the risk of cachexia and prognosis in patients with MM. (Source: Cancers)
Source: Cancers - March 24, 2024 Category: Cancer & Oncology Authors: Marcin Mazurek Aneta Szudy-Szczyrek Iwona Homa-Mlak Marek Hus Teresa Ma łecka-Massalska Rados ław Mlak Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1264: Navigating Head and Neck Porocarcinoma: Systematic Review with Special Emphasis on Surgical Safety Margins
We present a systematic review analysing the surgical margins of porocarcinoma in the head and neck area, which was conducted across the PubMed, Cochrane, and Web of Science databases including studies published from inception to November of 2023. In this systematic review, the PRISMA-ScR checklist was used, and a Cohen’s Kappa coefficient of 0.92 was applied, indicating very good agreement between reviewers. Out of 529 identified articles, 18 studies yielding 20 cases in total were selected for a thorough analysis. Nine (45%) cases were observed in the facial regions, eight (40%) on the scalp, and three (5%)...
Source: Cancers - March 24, 2024 Category: Cancer & Oncology Authors: Alvija Ku činskaitė Gintar ė Ulianskaitė Justinas Pamedys Domantas Stundys Tags: Systematic Review Source Type: research

Cancers, Vol. 16, Pages 1258: Correlation of Bronchoscopy and CT in Characterizing Malignant Central Airway Obstruction
Conclusions: CT demonstrates reasonable agreement with bronchoscopy in detecting obstruction. Nevertheless, when CT indicates a positive finding for MCAO, it is advisable to conduct bronchoscopy. This is because CT lacks reliability in determining the severity of obstruction and identifying the mucosal component of mixed disease. (Source: Cancers)
Source: Cancers - March 23, 2024 Category: Cancer & Oncology Authors: Sukumar Kalvapudi Hafiz M. Zubair Rajesh Kunadharaju Sajeer Bhura Hiwot Mengiste Musa Saeed Arjun Saradna Harshwant Grover Gal Shafirstein Sai Yendamuri Nathaniel M. Ivanick Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1259: Racial Differences in Vaginal Fluid Metabolites and Association with Systemic Inflammation Markers among Ovarian Cancer Patients: A Pilot Study
ski Tomi Akinyemiju The vaginal microbiome differs by race and contributes to inflammation by directly producing or consuming metabolites or by indirectly inducing host immune response, but its potential contributions to ovarian cancer (OC) disparities remain unclear. In this exploratory cross-sectional study, we examine whether vaginal fluid metabolites differ by race among patients with OC, if they are associated with systemic inflammation, and if such associations differ by race. Study participants were recruited from the Ovarian Cancer Epidemiology, Healthcare Access, and Disparities Study between March 2021 and ...
Source: Cancers - March 23, 2024 Category: Cancer & Oncology Authors: Oyomoare L. Osazuwa-Peters April Deveaux Michael J. Muehlbauer Olga Ilkayeva James R. Bain Temitope Keku Andrew Berchuck Bin Huang Kevin Ward Margaret Gates Kuliszewski Tomi Akinyemiju Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1260: Sex-Specific Expression of Histone Lysine Demethylases (KDMs) in Thyroid Cancer
Conclusions: Normal thyroids have a sex-specific molecular signature, and the development of thyroid cancer is associated with a differential expression of sex-biased genes. The sex-specific expression of KDMs, coupled with cancer-related alterations in their intracellular localization, may contribute to mechanisms underlying sex differences in thyroid tumorigenesis. (Source: Cancers)
Source: Cancers - March 23, 2024 Category: Cancer & Oncology Authors: Leila Shobab Hui Zheng Kirk Jensen Maria Cecilia Mendonca-Torres Matthew McCoy Victoria Hoperia Jennifer Rosen Leonard Wartofsky Kenneth Burman Vasyl Vasko Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1261: Predictors of Progression in a Series of 81 Adult Patients Surgically Managed for an Intracranial Hemangioblastoma: Implications for the Postoperative Follow-Up
anneau François Ducray Chloe Dumot Thiebaud Picart The aim was to identify predictors of progression in a series of patients managed for an intracranial hemangioblastoma, in order to guide the postoperative follow-up modalities. The characteristics of 81 patients managed for an intracranial hemangioblastoma between January 2000 and October 2022 were retrospectively analyzed. The mean age at diagnosis was of 48 ± 16 years. Eleven (14%) patients had von Hippel–Lindau disease. The most frequent tumor location was the cerebellar hemispheres (n = 51, 65%) and 11 (14%) patients had multice...
Source: Cancers - March 23, 2024 Category: Cancer & Oncology Authors: Elisabeth Garrido Huy Le Ngoc Jacques Guyotat Isabelle Pelissou-Guyotat Timoth ée Jacquesson Violaine Delabar Romain Manet Cl émentine Gallet Tanguy Fenouil Nathalie Streichenberger Alexandre Vasiljevic David Meyronet Emmanuel Jouanneau Fran çois Ducra Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1262: Design and Preclinical Evaluation of a Novel Prostate-Specific Membrane Antigen Radioligand Modified with a Transthyretin Binder
This study was the first of this kind and could motivate the use of the “transthyretin binder concept” for the development of future radiopharmaceuticals. (Source: Cancers)
Source: Cancers - March 23, 2024 Category: Cancer & Oncology Authors: Christian Vaccarin Ana Katrina Mapanao Luisa M. Deberle Anna E. Becker Francesca Borgna Giovanni Marzaro Roger Schibli Cristina M üller Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1257: Could Periodontitis Increase the Risk of Suffering from Pancreatic Cancer? & mdash;A Systematic Review
Conclusions: Through this systematic review, we have seen how periodontitis can be related to PC and how it worsens its prognosis. Knowing the behavior of periodontopathogenic bacteria and the influence they have on our immune and inflammatory system may help to achieve an interdisciplinary approach to both pathologies. (Source: Cancers)
Source: Cancers - March 23, 2024 Category: Cancer & Oncology Authors: Cecilia Fabiana M árquez-Arrico Francisco Javier Silvestre Julia Elena Marquez-Arrico Javier Silvestre-Rangil Tags: Systematic Review Source Type: research

Cancers, Vol. 16, Pages 1249: Intracranial Efficacy of Atezolizumab, Bevacizumab, Carboplatin, and Paclitaxel in Real-World Patients with Non-Small-Cell Lung Cancer and EGFR or ALK Alterations
Carles Escriu Contrary to Pemetrexed-containing chemo-immunotherapy studies, Atezolizumab, Bevacizumab, Carboplatin, and Paclitaxel (ABCP) treatment has consistently shown clinical benefit in prospective studies in patients with lung cancer and actionable mutations, where intracranial metastases are common. Here, we aimed to describe the real-life population of patients fit to receive ABCP after targeted therapy and quantify its clinical effect in patients with brain metastases. Patients treated in Cheshire and Merseyside between 2019 and 2022 were identified. Data were collected retrospectively. A total of 34 patient...
Source: Cancers - March 22, 2024 Category: Cancer & Oncology Authors: Marcus Rathbone Conor O ’Hagan Helen Wong Adeel Khan Timothy Cook Sarah Rose Jonathan Heseltine Carles Escriu Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1250: Impact of RRP1B Variants on the Phenotype, Progression, and Metastasis of Cervical Cancer
This study investigates the involvement of the ribosomal RNA processing 1 homolog B (RRP1B) gene in metastasis regulation in cervical cancer. Through a comprehensive analysis of 172 cervical cancer patients, we evaluated five RRP1B single nucleotide polymorphisms (SNPs) (rs2838342, rs7276633, rs2051407, rs9306160, and rs762400) for their associations with clinicopathological features and survival outcomes. Significant associations were observed between specific genetic variants and clinicopathological parameters. Notably, the A allele of rs2838342 was associated with reduced odds of advanced tumor size, worse prognosis, an...
Source: Cancers - March 22, 2024 Category: Cancer & Oncology Authors: Egl ė Balčiūnienė Arturas In čiūra Elona Juozaityt ė Rasa Ugenskien ė Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1251: Effectiveness of Immunotherapy in Non-Small Cell Lung Cancer Patients with a Diagnosis of COPD: Is This a Hidden Prognosticator for Survival and a Risk Factor for Immune-Related Adverse Events?
Mario Roselli The interplay between the immune system and chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC) is complex and multifaceted. In COPD, chronic inflammation and oxidative stress can lead to immune dysfunction that can exacerbate lung damage, further worsening the respiratory symptoms. In NSCLC, immune cells can recognise and attack the cancer cells, which, however, can evade or suppress the immune response by various mechanisms, such as expressing immune checkpoint proteins or secreting immunosuppressive cytokines, thus creating an immunosuppressive tumour microenvironment ...
Source: Cancers - March 22, 2024 Category: Cancer & Oncology Authors: Silvia Riondino Roberto Rosenfeld Vincenzo Formica Cristina Morelli Giusy Parisi Francesco Torino Sabrina Mariotti Mario Roselli Tags: Review Source Type: research

Cancers, Vol. 16, Pages 1252: Emerging New Targets in Systemic Therapy for Malignant Pleural Mesothelioma
ova Malignant pleural mesothelioma (MPM) is a heterogeneous cancer composed of distinct molecular and pathologic subtypes. Unfortunately, MPM is aggressive, and current therapies for advanced, unresectable disease remain limited to cytotoxic chemotherapy and immunotherapy. Our understanding of the genomic landscape of MPM is steadily growing, while the discovery of effective targeted therapies in MPM has advanced more slowly than in other solid tumors. Given the prevalence of alterations in tumor suppressor genes in MPM, it has been challenging to identify actionable targets. However, efforts to characterize the geneti...
Source: Cancers - March 22, 2024 Category: Cancer & Oncology Authors: Karen M. Yun Lyudmila Bazhenova Tags: Review Source Type: research