Cancers, Vol. 16, Pages 1464: The Gut Connection: Exploring the Possibility of Implementing Gut Microbial Metabolites in Lymphoma Treatment
Bhuyan
Recent research has implicated the gut microbiota in the development of lymphoma. Dysbiosis of the gut microbial community can disrupt the production of gut microbial metabolites, thereby impacting host physiology and potentially contributing to lymphoma. Dysbiosis-driven release of gut microbial metabolites such as lipopolysaccharides can promote chronic inflammation, potentially elevating the risk of lymphoma. In contrast, gut microbial metabolites, such as short-chain fatty acids, have shown promise in preclinical studies by promoting regulatory T-cell function, suppressing inflammation, and potentially preve...
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Ahmad K. Al-Khazaleh Dennis Chang Gerald W. M ünch Deep Jyoti Bhuyan Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1465: Development and Validation of an Inflammatory Prognostic Index to Predict Outcomes in Advanced/Metastatic Urothelial Cancer Patients Receiving Immune Checkpoint Inhibitors
Conclusions: The lack of a baseline systemic inflammatory profile and the absence of early serum inflammatory biomarker changes are associated with significantly better outcomes on ICIs in a/mUC pts. The U-IPI is an easily applicable dynamic prognostic tool for PFS and OS, allowing for the early identification of a sub-group with dismal outcomes that would not benefit from ICIs, while distinguishing another that draws an important benefit. (Source: Cancers)
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Sara Mokbel Giuilia Baciarello Pernelle Lavaud Aurelius Omlin Fabio Calabr ò Richard Cathomas Stefanie Aeppli Pauline Parent Patrizia Giannatempo Kira-Lee Koster Naara Appel Philippe Gonnet Gesuino Angius Petros Tsantoulis Hendrick-Tobias Arkenau Carlo C Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1466: Long-Term Surgical Outcome of Class A and B Tympanomastoid Paragangliomas
Conclusions: Tympanomastoid PGL represents the most common neoplasm of the middle ear space. The most frequent presenting symptoms include pulsatile tinnitus and hearing loss, whereas the presence of retrotympanic mass was evident in all cases at the time of initial otoscopic evaluation. Proper documentation of facial function and audiometric evaluation are crucial elements of preoperative workup. The most preferred preoperative radiologic examination is high-resolution computer tomography (HRCT), whereas magnetic resonance imaging (MRI) with or without gadolinium enhancement is reserved for cases with a dilemma of carotid...
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Melcol Hailu Yilala Giuseppe Fancello Virginia Fancello Lorenzo Lauda Mario Sanna Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1467: Imaging of Peritoneal Metastases in Ovarian Cancer Using MDCT, MRI, and FDG PET/CT: A Systematic Review and Meta-Analysis
yropoulou
This review aims to compare the diagnostic performance of multidetector CT (MDCT), MRI, including diffusion-weighted imaging, and FDG PET/CT in the detection of peritoneal metastases (PMs) in ovarian cancer (OC). A comprehensive search was performed for articles published from 2000 to February 2023. The inclusion criteria were the following: diagnosis/suspicion of PMs in patients with ovarian/fallopian/primary peritoneal cancer; initial staging or suspicion of recurrence; MDCT, MRI and/or FDG PET/CT performed for the detection of PMs; population of at least 10 patients; surgical results, histopathologic analy...
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Athina C. Tsili George Alexiou Martha Tzoumpa Timoleon Siempis Maria I. Argyropoulou Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1456: A Phase Ib Expansion Cohort Evaluating Aurora A Kinase Inhibitor Alisertib and Dual TORC1/2 Inhibitor Sapanisertib in Patients with Advanced Solid Tumors
Conclusions: Dual targeting of Aurora A kinase and mTOR resulted in marginal clinical benefit in a population of patients with refractory solid tumors, including pancreatic adenocarcinoma, though individual patients experienced significant response to therapy. Correlatives indicate apoptotic response and tumor immune cell infiltrate may affect clinical outcomes. (Source: Cancers)
Source: Cancers - April 10, 2024 Category: Cancer & Oncology Authors: S. Lindsey Davis Wells A. Messersmith W. Thomas Purcell Elaine T. Lam Bradley R. Corr Alexis D. Leal Christopher H. Lieu Cindy L. O ’Bryant Stephen G. Smoots Evan D. Dus Kimberly R. Jordan Natalie J. Serkova Todd M. Pitts Jennifer R. Diamond Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1457: A Systematic Review and Meta-Analysis of 29 Studies Predicting Diagnostic Accuracy of CT, MRI, PET, and USG in Detecting Extracapsular Spread in Head and Neck Cancers
Conclusion: MRI is the most accurate imaging modality for detecting ECS in head and neck cancers. CT scan is a reasonable alternative, but PET scan may be considered when high specificity is required. USG may not add any further benefit in detecting ECS. (Source: Cancers)
Source: Cancers - April 10, 2024 Category: Cancer & Oncology Authors: Manish Mair Hitesh Singhavi Ameya Pai Mariya Khan Peter Conboy Oladejo Olaleye Rami Salha Phil Ameerally Ram Vaidhyanath Pankaj Chaturvedi Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1453: Emerging and Clinically Accepted Biomarkers for Hepatocellular Carcinoma
m
R. Matthew Walsh
Charles Miller
Koji Hashimoto
Andrea Schlegel
David Choon Hyuck Kwon
Federico Aucejo
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death and the sixth most diagnosed malignancy worldwide. Serum alpha-fetoprotein (AFP) is the traditional, ubiquitous biomarker for HCC. However, there has been an increasing call for the use of multiple biomarkers to optimize care for these patients. AFP, AFP-L3, and prothrombin induced by vitamin K absence II (DCP) have described clinical utility for HCC, but unfortunately, they also have well established and significant limitat...
Source: Cancers - April 10, 2024 Category: Cancer & Oncology Authors: Sami Fares Chase J. Wehrle Hanna Hong Keyue Sun Chunbao Jiao Mingyi Zhang Abby Gross Erlind Allkushi Melis Uysal Suneel Kamath Wen Wee Ma Jamak Modaresi Esfeh Maureen Whitsett Linganna Mazhar Khalil Alejandro Pita Jaekeun Kim R. Matthew Walsh Charles Mill Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1454: Radiomics Machine Learning Analysis of Clear Cell Renal Cell Carcinoma for Tumour Grade Prediction Based on Intra-Tumoural Sub-Region Heterogeneity
Conclusions: Radiomics signatures combined with ML have the potential to predict the WHO/ISUP grade of ccRCC with superior performance, when compared to pre-operative biopsy. Moreover, tumour sub-regions contain useful information that should be analysed independently when determining the tumour grade. Therefore, it is possible to distinguish the grade of ccRCC pre-operatively to improve patient care and management. (Source: Cancers)
Source: Cancers - April 10, 2024 Category: Cancer & Oncology Authors: Abeer J. Alhussaini J. Douglas Steele Adel Jawli Ghulam Nabi Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1455: Predictive Value of the Mayo Adhesive Probability (MAP) Score in Laparoscopic Partial Nephrectomies: A Systematic Review from the EAU Section of Uro-Technology (ESUT)
Ali Serdar Gözen
The Mayo Adhesive Probability (MAP) score is a radiographic scoring system that predicts the presence of adherent perinephric fat (APF) during partial nephrectomies (PNs). The purpose of this systematic review is to summarize the current literature on the application of the MAP score for predicting intraoperative difficulties related to APF and complications in laparoscopic PNs. Three databases, PubMed, Scopus and Cochrane, were screened, from inception to 29 October 2023, taking into consideration the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Guidelines. All the inc...
Source: Cancers - April 10, 2024 Category: Cancer & Oncology Authors: Panagiotis Kallidonis Theodoros Spinos Patricia Zondervan Peter Nyir ády Miguel Ram írez Backhaus Salvatore Micali Stephan Hruby Mario Alvarez-Maestro Vasileios Tatanis Evangelos Liatsikos Ali Serdar G özen Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1452: A Retrospective Review and Comprehensive Tumour Profiling of Advanced Non-Melanomatous Cutaneous Spindle Cell Neoplasms Treated with Immune-Checkpoint Inhibitors
In this study, we performed a single-center retrospective review of treatment outcomes for all advanced non-melanomatous cutaneous spindle cell neoplasms treated with ICIs. Blinded histopathology reviews occurred to confirm each diagnosis. Comprehensive tumour profiling included whole exome sequencing for tumour mutational burden (TMB) and ultraviolet(UV) signatures, and immunohistochemistry for immune-cell infiltration (CD4/CD3/CD8/CD103/CD20) and immune-checkpoint expression (PD-L1/LAG3/TIGIT). Seven patients were identified. The objective response rate was 86% (6/7) with five complete responses (CR). Responses were dura...
Source: Cancers - April 10, 2024 Category: Cancer & Oncology Authors: Luke S. McLean Annette M. Lim Christopher Angel Richard J. Young Angela Pizzolla Stuart Archer Benjamin J. Solomon Alesha A. Thai Jeremy Lewin Danny Rischin Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1447: Emerging Therapies in Kirsten Rat Sarcoma Virus (+) Non-Small-Cell Lung Cancer
Syrigos
Kirsten rat sarcoma virus (KRAS) is the most frequently found oncogene in human cancers, including non-small-cell lung cancer (NSCLC). For many years, KRAS was considered “undruggable” due to its structure and difficult targeting. However, the discovery of the switch II region in the KRAS-G12C-mutated protein has changed the therapeutic landscape with the design and development of novel direct KRAS-G12C inhibitors. Sotorasib and adagrasib are FDA-approved targeted agents for pre-treated patients with KRAS-G12C-mutated NSCLC. Despite promising results, the efficacy of these novel inhi...
Source: Cancers - April 9, 2024 Category: Cancer & Oncology Authors: Anastasia Karachaliou Elias Kotteas Oraianthi Fiste Konstantinos Syrigos Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1449: The Prognostic Impact of the Surgical Margin in Renal Cell Carcinoma Treated with Partial Nephrectomy: A Multi-Center Study
Conclusions: Our study presents further evidence on the negative impact of PSM on recurrence after PN for RCC, highlighting the importance of achieving NSM, thus potentially improving clinical outcomes. A surgical approach was found to be the only predictive factor influencing the risk of PSMs, with a reduced risk observed with robot-assisted laparoscopy. (Source: Cancers)
Source: Cancers - April 9, 2024 Category: Cancer & Oncology Authors: Karina Sif S øndergaard Mosholt Mark Aagaard Andreas R øder Nessn Azawi Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1448: Chromatin Profiles Are Prognostic of Clinical Response to Bortezomib-Containing Chemotherapy in Pediatric Acute Myeloid Leukemia: Results from the COG AAML1031 Trial
erzah M. Horton
Steven M. Kornblau
The addition of the proteasome inhibitor bortezomib to standard chemotherapy did not improve survival in pediatric acute myeloid leukemia (AML) when all patients were analyzed as a group in the Children’s Oncology Group phase 3 trial AAML1031 (NCT01371981). Proteasome inhibition influences the chromatin landscape and proteostasis, and we hypothesized that baseline proteomic analysis of histone- and chromatin-modifying enzymes (HMEs) would identify AML subgroups that benefitted from bortezomib addition. A proteomic profile of 483 patients treated with AAML1031 chemother...
Source: Cancers - April 9, 2024 Category: Cancer & Oncology Authors: Anneke D. van Dijk Fieke W. Hoff Yihua Qiu Stefan E. Hubner Robin L. Go Vivian R. Ruvolo Amanda R. Leonti Robert B. Gerbing Alan S. Gamis Richard Aplenc Edward A. Kolb Todd A. Alonzo Soheil Meshinchi Eveline S. J. M. de Bont Terzah M. Horton Steven M. Kor Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1450: Cancer and Cardiovascular Disease: The Conjoined Twins
Rohit Moudgil
Cancer and cardiovascular disease are the two most common causes of death worldwide. As the fields of cardiovascular medicine and oncology continue to expand, the area of overlap is becoming more prominent demanding dedicated attention and individualized patient care. We have come to realize that both fields are inextricably intertwined in several aspects, so much so that the mere presence of one, with its resultant downstream implications, has an impact on the other. Nonetheless, cardiovascular disease and cancer are generally approached independently. The focus that is granted to the predominant patholo...
Source: Cancers - April 9, 2024 Category: Cancer & Oncology Authors: Mohammad Zmaili Jafar Alzubi Motasem Alkhayyat Almaza Albakri Feras Alkhalaileh Joshua Longinow Rohit Moudgil Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1451: Validation of the Standardized Needs Evaluation Questionnaire in Polish Cancer Patients
Conclusion: The NEQ is a simple, easy-to-administer instrument with good psychometric properties and seems to be useful in assessing the unexpressed needs of cancer patients. (Source: Cancers)
Source: Cancers - April 9, 2024 Category: Cancer & Oncology Authors: Karolina Osowiecka Anna Doli ńska Marek Szwiec Eliza Dzia łach Jacek J. Nowakowski Monika Ruci ńska Tags: Article Source Type: research
