Cancers, Vol. 16, Pages 1638: Emotional Distress, Cognitive Complaints, and Care Needs among Advanced Cancer Survivors Treated with Immune Checkpoint Blockade: A Mixed-Method Study
Conclusion: Our results indicate the existence of persistent psychological, physical, and cognitive issues, and support the need for routine screening for FCR. The identified triggers related to severe psychological distress can aid clinicians in timely referring the patient, thereby enhancing survivorship care. (Source: Cancers)
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Nathalie Vanlaer Iris Dirven Bart Neyns Anne Rogiers Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1639: LINC01021 Attenuates Expression and Affects Alternative Splicing of a Subset of p53-Regulated Genes
Conclusions: Our results suggest that LINC01021 may restrict the extent and strength of p53-mediated transcriptional changes via context-dependent regulation of the expression and splicing of a subset of p53-regulated genes. (Source: Cancers)
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Kaller Forn é Imhof Hermeking Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1640: Histological Patterns and Mammographic Presentation of Invasive Lobular Carcinoma Show No Obvious Associations
őző
Invasive lobular carcinoma of the breast has different mammographic appearances, including spiculated or lobulated masses, architectural distortion, increased breast density, and the possibility of also being occult. Histologically, the morphology is also variable, as several patterns have been described beside the classical one, including the solid, the alveolar, the trabecular, the one with tubular elements, and others. Of 146 ILC cases, 141 were reviewed for mammographic appearance and 136 for histological patterns by two radiologist and two pathologists, respectively; 132 common cases were analyzed for possib...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: G ábor Cserni Rita Bori Éva Ambrózay Orsolya Serf őző Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1641: Detection and Real-Time Surgical Assessment of Colorectal Liver Metastases Using Near-Infrared Fluorescence Imaging during Laparoscopic and Robotic-Assisted Resections
Conclusions: ICG fluorescence imaging can be integrated with other conventional intraoperative imaging techniques to optimize intraoperative staging. Rim fluorescence proved to be a valid indicator of the resection margins: by removing the entire fluorescent area, a tumor-negative resection (R0) is achieved. (Source: Cancers)
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Piccolo Barabino Ghilardi Masserano Lecchi Piozzi Bianchi Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1642: Assessing the Effects of Curcumin and 450 nm Photodynamic Therapy on Oxidative Metabolism and Cell Cycle in Head and Neck Squamous Cell Carcinoma: An In Vitro Study
Andrea Amaroli
Oral cancer is the 16th most common malignant tumor worldwide. The risk of recurrence and mortality is high, and the survival rate is low over the following five years. Recent studies have shown that curcumin causes apoptosis in tumor cells by affecting FoF1-ATP synthase (ATP synthase) activity, which, in turn, hinders cell energy production, leading to a loss of cell viability. Additionally, irradiation of curcumin within cells can intensify its detrimental effects on cancer cell viability and proliferation (photodynamic therapy). We treated the OHSU-974 cell line, a model for human head and neck squam...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Silvia Ravera Claudio Pasquale Isabella Panfoli Matteo Bozzo Dimitrios Agas Silvia Bruno Michael R. Hamblin Andrea Amaroli Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1628: Peripheral Soluble Immune Checkpoint-Related Proteins Were Associated with Survival and Treatment Efficacy of Osteosarcoma Patients, a Cohort Study
Conclusion: Four soluble ICK-related proteins were associated with the survival of OS patients. Soluble ICK-related proteins could be promising biomarkers for the outcomes and immunotherapy of OS patients, though more research is warranted. (Source: Cancers)
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Binghao Li Qinchuan Wang Yihong Luo Sicong Wang Sai Pan Wenting Zhao Zhaoming Ye Xifeng Wu Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1629: Serum Proteomic Signatures in Cervical Cancer: Current Status and Future Directions
We report on identified multimarker panels of serum proteomic studies in CC for the past 5 years, the potential for modern computational biology efforts, and the utilization of nationwide biobanks to bridge the gap between multivariate protein signature development and the prediction of clinically relevant CC patient outcomes. (Source: Cancers)
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Chaston Weaver Alisha Nam Caitlin Settle Madelyn Overton Maya Giddens Katherine P. Richardson Rachael Piver David P. Mysona Bunja Rungruang Sharad Ghamande Richard McIndoe Sharad Purohit Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1627: Correction: Mathew et al. Metabolic Signature of Warburg Effect in Cancer: An Effective and Obligatory Interplay between Nutrient Transporters and Catabolic/Anabolic Pathways to Promote Tumor Growth. Cancers 2024, 16, 504
Ganapathy
In the original publication [...] (Source: Cancers)
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Marilyn Mathew Nhi T. Nguyen Yangzom D. Bhutia Sathish Sivaprakasam Vadivel Ganapathy Tags: Correction Source Type: research
Cancers, Vol. 16, Pages 1630: Patient-Reported Outcomes after Laser Ablation for Bladder Tumours Compared to Transurethral Resection & mdash;A Prospective Study
Cancers, Vol. 16, Pages 1630: Patient-Reported Outcomes after Laser Ablation for Bladder Tumours Compared to Transurethral Resection—A Prospective Study
Cancers doi: 10.3390/cancers16091630
Authors:
Nina Nordtorp Deacon
Ninna Kjær Nielsen
Jørgen Bjerggaard Jensen
The standard procedure for diagnosis and treatment of bladder tumours, transurethral resection of bladder tumour (TURBT), is associated with a complication rate of up to 26% and potentially has severe influence on patient-reported outcomes (PRO). Outpatient transurethral laser ablation (TULA) is an emerging new modality that is less invasiv...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Nina Nordtorp Deacon Ninna Kj ær Nielsen J ørgen Bjerggaard Jensen Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1631: Laparoscopic Treatment of Bulky Nodes in Primary and Recurrent Ovarian Cancer: Surgical Technique and Outcomes from Two Specialized Italian Centers
Conclusions: The results of our study are consistent with those reported in the literature, demonstrating that MIS may represent a safe approach in advanced and recurrent EOC with nodal metastasis if performed on selected patients by expert surgeons with an adequate setting and appropriate technique. (Source: Cancers)
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Alberto Daniele Roberta Rosso Marcello Ceccaroni Giovanni Roviglione Gianmarco D ’Ancona Elisa Peano Valentino Clignon Valerio Calandra Andrea Puppo Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1632: Evidence and Future Perspectives for Neoadjuvant Therapy for Resectable and Borderline Resectable Pancreatic Cancer: A Scoping Review
agawa
Pancreatic cancer (PC) is a lethal disease that requires innovative therapeutic approaches to enhance the survival outcomes. Neoadjuvant treatment (NAT) has gained attention for resectable and borderline resectable PC, offering improved resection rates and enabling early intervention and patient selection. Several retrospective studies have validated its efficacy. However, previous studies have lacked intention-to-treat analyses and appropriate resectability classifications. Randomized comparative trials may help to enhance the clinical applicability of evidence. Therefore, after searching the MEDLINE database, t...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Yutaka Endo Minoru Kitago Yuko Kitagawa Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1633: What Is the Impact of Multimodal Treatment in Patients with Leiomyosarcoma of Bone? A Multicenter Study of 35 Patients with an Ultra-Rare Tumor Entity
Dimosthenis Andreou
Primary leiomyosarcoma of bone (LMSoB) is extremely rare, comprising only <0.7% of primary malignant bone tumors, and is therefore considered an ultra-rare tumor entity. There is currently no consensus as to whether therapeutic strategies should be based on the biological characteristics of soft tissue leiomyosarcoma or on primary tumor localization in the bone. The use of perioperative chemotherapy and its effectiveness in this rare tumor entity remains unclear. We aimed to evaluate the impact of different treatment approaches in a multicenter setting with a total of 35 patients included...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Maya Niethard Carolin Knebel Andreas Leithner Per-Ulf Tunn Janosch Schoon Peter Reichardt Athanasios Pogkas Joanna Szkandera Daniel Pink Dimosthenis Andreou Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1634: Late Changes in Renal Volume and Function after Proton Beam Therapy in Pediatric and Adult Patients: Children Show Significant Renal Atrophy but Deterioration of Renal Function Is Minimal in the Long-Term in Both Groups
ei Nakai
Satoshi Kamizawa
Chie Kawano
Yoshiko Oshiro
Hideyuki Sakurai
To compare late renal effects in pediatric and adult patients with malignancies after PBT involving part of the kidney. A retrospective study was conducted to assess changes in renal volume and function in 24 patients, including 12 children (1–14 years old) and 12 adults (51–80 years old). Kidney volumes were measured from CT or MRI images during follow-up. Dose-volume histograms were calculated using a treatment planning system. In children, the median volume changes for the irradiated and control kidneys were &am...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Yinuo Li Masashi Mizumoto Hazuki Nitta Hiroko Fukushima Ryoko Suzuki Sho Hosaka Yuni Yamaki Motohiro Murakami Keiichiro Baba Masatoshi Nakamura Toshiki Ishida Hirokazu Makishima Takashi Iizumi Takashi Saito Haruko Numajiri Kei Nakai Satoshi Kamizawa Chie Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1635: Laryngeal Cancer Cells Metabolize 25-Hydroxyvitamin D3 and Respond to 24R,25-dihydroxyvitamin D3 via a Mechanism Dependent on Estrogen Receptor Levels
Zvi Schwartz
Studies have evaluated vitamin D3’s therapeutic potential in estrogen-responsive cancers, with conflicting findings. We have shown that the proliferation of breast cancer cells is regulated by 24R,25-dihydroxyvitamin D3 (24R,25(OH)2D3) depending on estrogen receptor alpha 66 (ERα66) expression, suggesting that this could also be the case for estrogen-sensitive laryngeal cancer cells. Accordingly, we examined levels of ERα isoforms in ERα66-positive UM-SCC-12 and ERα66-negative UM-SCC-11A cells and their response to 24R,25(OH)2D3. 24R,...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Cydney D. Dennis Jonathan T. Dillon Prit H. Patel David J. Cohen Matthew S. Halquist Adam C. Pearcy Barbara D. Boyan Zvi Schwartz Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1636: Heterocellular Adhesion in Cancer Invasion and Metastasis: Interactions between Cancer Cells and Cancer-Associated Fibroblasts
aki
Cancer invasion is a requisite for the most malignant progression of cancer, that is, metastasis. The mechanisms of cancer invasion were originally studied using in vitro cell culture systems, in which cancer cells were cultured using artificial extracellular matrices (ECMs). However, conventional culture systems do not precisely recapitulate in vivo cancer invasion because the phenotypes of cancer cells in tumor tissues are strongly affected by the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are the most abundant cell type in the TME and accelerate cancer progression through invasion, metast...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Hideki Yamaguchi Makoto Miyazaki Tags: Review Source Type: research
