Cancers, Vol. 16, Pages 1634: Late Changes in Renal Volume and Function after Proton Beam Therapy in Pediatric and Adult Patients: Children Show Significant Renal Atrophy but Deterioration of Renal Function Is Minimal in the Long-Term in Both Groups

Cancers, Vol. 16, Pages 1634: Late Changes in Renal Volume and Function after Proton Beam Therapy in Pediatric and Adult Patients: Children Show Significant Renal Atrophy but Deterioration of Renal Function Is Minimal in the Long-Term in Both Groups Cancers doi: 10.3390/cancers16091634 Authors: Yinuo Li Masashi Mizumoto Hazuki Nitta Hiroko Fukushima Ryoko Suzuki Sho Hosaka Yuni Yamaki Motohiro Murakami Keiichiro Baba Masatoshi Nakamura Toshiki Ishida Hirokazu Makishima Takashi Iizumi Takashi Saito Haruko Numajiri Kei Nakai Satoshi Kamizawa Chie Kawano Yoshiko Oshiro Hideyuki Sakurai To compare late renal effects in pediatric and adult patients with malignancies after PBT involving part of the kidney. A retrospective study was conducted to assess changes in renal volume and function in 24 patients, including 12 children (1–14 years old) and 12 adults (51–80 years old). Kidney volumes were measured from CT or MRI images during follow-up. Dose-volume histograms were calculated using a treatment planning system. In children, the median volume changes for the irradiated and control kidneys were −5.58 (−94.95 to +4.79) and +14.92 (−19.45 to +53.89) mL, respectively, with a relative volume change of −28.38 (−119.45 to −3.87) mL for the irradiated kidneys. For adults, these volume changes were −22.43 (&minu...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research