Cancers, Vol. 16, Pages 1433: Translational Aspects in Metaplastic Breast Carcinoma
This article reviews and summarizes the current knowledge and translational aspects of MpBC. (Source: Cancers)
Source: Cancers - April 7, 2024 Category: Cancer & Oncology Authors: Elizve Nairoby Barrientos-Toro Qingqing Ding Maria Gabriela Raso Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1431: A Plausible Framework Reveals Potential Similarities in the Regulation of Immunity against Some Cancers and Some Infectious Agents: Implications for Prevention and Treatment
r
Different frameworks, which are currently employed to understand how immune responses are regulated, can account for different observations reported in the classical literature. I have argued that the predominant frameworks, employed over the last two/three decades to analyze the circumstances that determine whether an immune response is generated or this potential is ablated, and that determine the class of immunity an antigen induces, are inconsistent with diverse classical observations. These observations are “paradoxical” within the context of these frameworks and, consequently, tend t...
Source: Cancers - April 7, 2024 Category: Cancer & Oncology Authors: Peter A. Bretscher Tags: Perspective Source Type: research
Cancers, Vol. 16, Pages 1434: Identifying the Spatial Architecture That Restricts the Proximity of CD8+ T Cells to Tumor Cells in Pancreatic Ductal Adenocarcinoma
In this study, co-detection by indexing (CODEX) was designed to characterize PDAC tissue regions with seven protein markers in order to identify the spatial architecture that regulates CD8+ T cells in human pancreatic ductal adenocarcinoma (PDAC). The cellular neighborhood algorithm was used to identify a total of six conserved and distinct cellular neighborhoods. Among these, one unique spatial architecture of CD8+ T and CD4+ T cell-enriched neighborhoods enriched the majority of CD8+ T cells, but heralded a poor prognosis. The proximity analysis revealed that the CD8+ T cells in this spatial architecture were significant...
Source: Cancers - April 7, 2024 Category: Cancer & Oncology Authors: Yihan Xia Junrui Ma Xiaobao Yang Danping Liu Yujie Zhu Yanan Zhao Xuefeng Fei Dakang Xu Jing Dai Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1422: The Current and Prospective Adjuvant Therapies for Hepatocellular Carcinoma
Wang
Hepatocellular carcinoma (HCC) stands as the most prevalent form of primary liver cancer and is highly invasive and easily recurs. For HCC, chemotherapy shows limited effect. The gold standard for HCC treatment includes curative surgical resection or liver transplantation. However, the recurrence rate at 5 years after liver resection is estimated at approximately 70% and even at 5 years after liver transplantation, it is 20%. Therefore, improving survival outcomes after curative surgical resection of liver cancer is crucial. This review highlights the importance of identifying risk factors for HCC recurrence foll...
Source: Cancers - April 6, 2024 Category: Cancer & Oncology Authors: Jeng-Shiun Du Shih-Hsien Hsu Shen-Nien Wang Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1423: Patterns of First Recurrence and Oncological Outcomes in Locally Advanced Cervical Cancer Patients: Does Surgical Staging Play a Role?
Conclusion: After treatment, surgically staged patients with LACC recurred more frequently and showed worse survival rates. (Source: Cancers)
Source: Cancers - April 6, 2024 Category: Cancer & Oncology Authors: Vicente Bebia Berta D íaz-Feijoo Álvaro Tejerizo Aureli Torne Virginia Benito Alicia Hern ández Mikel Gorostidi Santiago Domingo Melissa Bradbury Roc ío Luna-Guibourg Antonio Gil-Moreno Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1419: Late Relapse after Allogeneic Stem Cell Transplantation in Patients Treated for Acute Myeloid Leukemia: Relapse Incidence, Characteristics, Role of Conditioning Regimen, and Outcome
ierry Guillaume
Late relapse, beyond 2 years following alloHSCT for AML, is rare. Among the 376 patients allografted for AML in our center between 1990 and 2016, 142 (38%) relapsed. The majority (68%) of relapses occurred during the first year following transplantation. Beyond 2 years after alloHSCT, relapse was observed in 26 patients, representing 6.9% of the whole transplanted cohort and 18.3% of the relapsing patients. Cytogenetics at relapse was available in 21 patients and remained for 15 of them concordant to that at diagnosis. The majority (85.7%) of the patients were in CR prior to transplant. Thirteen patient...
Source: Cancers - April 5, 2024 Category: Cancer & Oncology Authors: Chlo é Antier Maxime Jullien Beno ît Tessoulin Marion Loirat Pierre Peterlin Alice Garnier Amandine Le Bourgeois Patrice Chevallier Thierry Guillaume Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1420: Growth Charts for Shwachman & ndash;Diamond Syndrome at Ages 0 to 18 Years
Cancers, Vol. 16, Pages 1420: Growth Charts for Shwachman–Diamond Syndrome at Ages 0 to 18 Years
Cancers doi: 10.3390/cancers16071420
Authors:
Anna Pegoraro
Valentino Bezzerri
Gloria Tridello
Cecilia Brignole
Francesca Lucca
Emily Pintani
Cesare Danesino
Simone Cesaro
Francesca Fioredda
Marco Cipolli
Shwachman–Diamond syndrome (SDS) is one of the most common inherited bone marrow failure syndromes. SDS is characterized by hypocellular bone marrow, with a severe impairment of the myeloid lineage, resulting in neutropenia, thrombocytopenia, and, more rarely, anemia. Almost 15...
Source: Cancers - April 5, 2024 Category: Cancer & Oncology Authors: Anna Pegoraro Valentino Bezzerri Gloria Tridello Cecilia Brignole Francesca Lucca Emily Pintani Cesare Danesino Simone Cesaro Francesca Fioredda Marco Cipolli Tags: Communication Source Type: research
Cancers, Vol. 16, Pages 1421: The Micro-Immunotherapy Medicine 2LPAPI & reg; Displays Immune-Modulatory Effects in a Model of Human Papillomavirus Type-16 L1-Protein Capsid-Treated Human Peripheral Blood Mononuclear Cells and Antiproliferative Effects in a Model of Cervical Cancer Cells
Cancers, Vol. 16, Pages 1421: The Micro-Immunotherapy Medicine 2LPAPI® Displays Immune-Modulatory Effects in a Model of Human Papillomavirus Type-16 L1-Protein Capsid-Treated Human Peripheral Blood Mononuclear Cells and Antiproliferative Effects in a Model of Cervical Cancer Cells
Cancers doi: 10.3390/cancers16071421
Authors:
Camille Jacques
Flora Marchand
Mathias Chatelais
Virginie Albinet
Claire Coustal
Ilaria Floris
Human papillomavirus (HPV) is the second most common infectious agent causing cancer. Persistent infection with high-risk (HR)-HPV can lead to cervical intra-epithelial neoplasia an...
Source: Cancers - April 5, 2024 Category: Cancer & Oncology Authors: Camille Jacques Flora Marchand Mathias Chatelais Virginie Albinet Claire Coustal Ilaria Floris Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1416: Real-World Electronic Medical Records Data Identify Risk Factors for Myelofibrosis and Can Be Used to Validate Established Prognostic Scores
This study leverages the TriNetX database with more than 64,000 MF patients to assess the impact of accessible parameters on survival and complicating events, including AML transformation, cachexia, increased systemic inflammation, thrombosis and hemorrhage. Age over 65 years correlated with increased risks of death, AML transformation, thrombosis and hemorrhage. Anemia (Hb < 10 g/dL), leukocytosis (>25 × 103/µL) and thrombocytopenia (<150 × 103/µL) reduced survival and increased risks across all assessed events. Monocytosis is associa...
Source: Cancers - April 5, 2024 Category: Cancer & Oncology Authors: Max Kappenstein Nikolas von Bubnoff Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1417: Safety of the Breast Cancer Adjuvant Radiotherapy in Ataxia & ndash;Telangiectasia Mutated Variant Carriers
Cancers, Vol. 16, Pages 1417: Safety of the Breast Cancer Adjuvant Radiotherapy in Ataxia–Telangiectasia Mutated Variant Carriers
Cancers doi: 10.3390/cancers16071417
Authors:
Rayan Bensenane
Arnaud Beddok
Fabienne Lesueur
Alain Fourquet
Mathilde Warcoin
Marine Le Mentec
Eve Cavaciuti
Dorothée Le Gal
Séverine Eon-Marchais
Nadine Andrieu
Dominique Stoppa-Lyonnet
Youlia Kirova
The Ataxia–Telangiectasia Mutated (ATM) gene is implicated in DNA double-strand break repair. Controversies in clinical radiosensitivity remain known for monoallelic carriers of the ATM pathogenic...
Source: Cancers - April 5, 2024 Category: Cancer & Oncology Authors: Rayan Bensenane Arnaud Beddok Fabienne Lesueur Alain Fourquet Mathilde Warcoin Marine Le Mentec Eve Cavaciuti Doroth ée Le Gal S éverine Eon-Marchais Nadine Andrieu Dominique Stoppa-Lyonnet Youlia Kirova Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1418: Cisplatin-Resistant Urothelial Bladder Cancer Cells Undergo Metabolic Reprogramming beyond the Warburg Effect
In conclusion, cisplatin-resistant UBC cells seem to display deep metabolic alterations surpassing the Warburg effect, which likely depend on the molecular signature of each cell line. (Source: Cancers)
Source: Cancers - April 5, 2024 Category: Cancer & Oncology Authors: Julieta Afonso Catarina Barbosa-Matos Ricardo Silvestre Joana Pereira-Vieira Samuel Martins Gon çalves Camille Mendes-Alves Pier Parpot Joana Pinto Ângela Carapito Paula Guedes de Pinho L úcio Santos Adhemar Longatto-Filho F átima Baltazar Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1413: Precision Immuno-Oncology in NSCLC through Gender Equity Lenses
Narjust Florez
Precision immuno-oncology involves the development of personalized cancer treatments that are influenced by the unique nature of an individual’s DNA, immune cells, and their tumor’s molecular characterization. Biological sex influences immunity; females typically mount stronger innate and adaptive immune responses than males. Though more research is warranted, we continue to observe an enhanced benefit for females with lung cancer when treated with combination chemoimmunotherapy in contrast to the preferred approach of utilizing immunotherapy alone in men. Despite the observe...
Source: Cancers - April 4, 2024 Category: Cancer & Oncology Authors: Jennifer Marks Arthi Sridhar Angela Ai Lauren Kiel Rebekah Kaufman Oyepeju Abioye Courtney Mantz Narjust Florez Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1414: Real-World Data and Evidence in Lung Cancer: A Review of Recent Developments
s Gkiozos
Conventional cancer clinical trials can be time-consuming and expensive, often yielding results with limited applicability to real-world scenarios and presenting challenges for patient participation. Real-world data (RWD) studies offer a promising solution to address evidence gaps and provide essential information about the effects of cancer treatments in real-world settings. The distinction between RWD and data derived from randomized clinical trials lies in the method of data collection, as RWD by definition are obtained at the point of care. Experimental designs resembling those used in traditional clinica...
Source: Cancers - April 4, 2024 Category: Cancer & Oncology Authors: Eleni Kokkotou Maximilian Anagnostakis Georgios Evangelou Nikolaos K. Syrigos Ioannis Gkiozos Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1415: Extracellular Vesicle-Related Non-Coding RNAs in Hepatocellular Carcinoma: An Overview
Cusimano
Hepatocellular carcinoma (HCC) is the most common primary liver cancer. It is a major public health problem worldwide, and it is often diagnosed at advanced stages, when no effective treatment options are available. Extracellular vesicles (EVs) are nanosized double-layer lipid vesicles containing various biomolecule cargoes, such as lipids, proteins, and nucleic acids. EVs are released from nearly all types of cells and have been shown to play an important role in cell-to-cell communication. In recent years, many studies have investigated the role of EVs in cancer, including HCC. Emerging studies have shown th...
Source: Cancers - April 4, 2024 Category: Cancer & Oncology Authors: Augello Cusimano Cervello Cusimano Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1411: Prognostic Value of PCSK9 Levels in Premenopausal Women at Risk of Breast Cancer & mdash;Evidence from a 17-Year Follow-Up Study
Conclusions: In premenopausal women at risk of early-stage breast cancer, PCSK9 did not appear to have a role as a prognostic biomarker of breast neoplastic events. Larger studies are warranted investigating patients in different settings. (Source: Cancers)
Source: Cancers - April 4, 2024 Category: Cancer & Oncology Authors: Massimiliano Ruscica Chiara Macchi Sara Gandini Debora Macis Aliana Guerrieri-Gonzaga Valentina Aristarco Davide Serrano Matteo Lazzeroni Alessandra Stefania Rizzuto Aurora Gaeta Alberto Corsini Marcella Gulisano Harriet Johansson Bernardo Bonanni Tags: Article Source Type: research
