Cancers, Vol. 16, Pages 1650: Clinical Management of Intraductal Carcinoma of the Prostate
©rat
Intraductal carcinoma of the prostate (IDC-P) has emerged as a distinct entity with significant clinical implications in prostate cancer (PCa) management. Despite historically being considered an extension of invasive PCa, IDC-P shows unique biological characteristics that challenge traditional diagnostic and therapeutic settings. This review explores the clinical management of IDC-P. While the diagnosis of IDC-P relies on specific morphological criteria, its detection remains challenging due to inter-observer variability. Emerging evidence underscores the association of IDC-P with aggressive disease and poor clin...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Gabriel Wasinger Olivier Cussenot Eva Comp érat Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1649: The Safety and Efficacy of the Combination of Sacituzumab Govitecan and Palliative Radiotherapy & mdash;A Retrospective Multi-Center Cohort Study
We report here a systematic review, as well as a retrospective multi-center study of 17 patients with triple-negative breast cancer who received concurrent SG and radiotherapy. In these patients, concurrent use was found to be efficient, safe and well tolerated. There were no apparent differences in moderate or severe acute toxicity according to the timing of SG administration. (Source: Cancers)
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: David Krug Joke Tio Ali Abaci Bj örn Beurer Sandra Br ügge Khaled Elsayad Eva Meixner Tjoung-Won Park-Simon Katharina Smetanay Franziska Winkelmann Andrea Wittig Achim W öckel Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1651: Liver X Receptor Ligand GAC0001E5 Downregulates Antioxidant Capacity and ERBB2/HER2 Expression in HER2-Positive Breast Cancer Cells
In this study, HER2-positive breast cancer cells were treated with 1E5 to determine their potential inhibitory effects and mechanisms of action in HER2-positive breast cancers. Similar to previous observations in other cancer types, 1E5 treatments inhibited LXR activity, expression, and cancer cell proliferation. Expression of fatty acid synthesis genes, including fatty acid synthase (FASN), was downregulated following 1E5 treatment, and results from co-treatment experiments with an FASN inhibitor suggest that the same pathway is targeted by 1E5. Treatments with 1E5 disrupted glutaminolysis and resulted in increased oxidat...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Asitha Premaratne Shinjini Basu Abhinav Bagchi Tianyi Zhou Qin Feng Chin-Yo Lin Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1653: A Metastatic Cancer Expression Generator (MetGen): A Generative Contrastive Learning Framework for Metastatic Cancer Generation
i Huang
Despite significant advances in tumor biology and clinical therapeutics, metastasis remains the primary cause of cancer-related deaths. While RNA-seq technology has been used extensively to study metastatic cancer characteristics, challenges persist in acquiring adequate transcriptomic data. To overcome this challenge, we propose MetGen, a generative contrastive learning tool based on a deep learning model. MetGen generates synthetic metastatic cancer expression profiles using primary cancer and normal tissue expression data. Our results demonstrate that MetGen generates comparable samples to actual metastatic ...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Zhentao Liu Yu-Chiao Chiu Yidong Chen Yufei Huang Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1652: Exosome-Mediated Paracrine Signaling Unveils miR-1246 as a Driver of Aggressiveness in Fusion-Negative Rhabdomyosarcoma
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Sandra E. Ghayad
Rhabdomyosarcoma is a pediatric cancer associated with aggressiveness and a tendency to develop metastases. Fusion-negative rhabdomyosarcoma (FN-RMS) is the most commonly occurring subtype of RMS, where metastatic disease can hinder treatment success and decrease survival rates. RMS-derived exosomes were previously demonstrated to be enriched with miRNAs, including miR-1246, possibly contributing to disease aggressiveness. We aimed to decipher the functional impact of exosomal miR-1246 on recipient cells and its role in promoting aggressiveness. Treatment of normal fibroblasts with FN-RMS-derived ...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Farah Ramadan Raya Saab Farah Ghamloush Rita Khoueiry Zdenko Herceg Ludovic Gomez Bassam Badran Philippe Clezardin Nader Hussein Pascale A. Cohen Sandra E. Ghayad Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1654: A Systematic Review of Prognostic Factors in Patients with Cancer Receiving Palliative Radiotherapy: Evidence-Based Recommendations
Conclusions: This evaluation has identified several factors or tools to aid in prognosis and clinical decision making. Future studies should aim to further validate these tools and factors in a clinical setting, including the leveraging of electronic medical records for data availability. To increase our understanding of how causal factors interact with palliative radiotherapy, future studies should also examine and include prediction of response to radiation as an outcome. (Source: Cancers)
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Alexander Tam Emanuela Scarpi Marco Cesare Maltoni Romina Rossi Alysa Fairchild Kristopher Dennis Marcus Vaska Marc Kerba Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1637: Pentraxin 3: A Main Driver of Inflammation and Immune System Dysfunction in the Tumor Microenvironment of Glioblastoma
Paola Capra
Brain tumors are a heterogeneous group of brain neoplasms that are highly prevalent in individuals of all ages worldwide. Within this pathological framework, the most prevalent and aggressive type of primary brain tumor is glioblastoma (GB), a subtype of glioma that falls within the IV-grade astrocytoma group. The death rate for patients with GB remains high, occurring within a few months after diagnosis, even with the gold-standard therapies now available, such as surgery, radiation, or a pharmaceutical approach with Temozolomide. For this reason, it is crucial to continue looking for cutting-edge therape...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Sarah Adriana Scuderi Alessio Ardizzone Ayomide Eniola Salako Giuseppe Pant ò Fabiola De Luca Emanuela Esposito Anna Paola Capra Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1638: Emotional Distress, Cognitive Complaints, and Care Needs among Advanced Cancer Survivors Treated with Immune Checkpoint Blockade: A Mixed-Method Study
Conclusion: Our results indicate the existence of persistent psychological, physical, and cognitive issues, and support the need for routine screening for FCR. The identified triggers related to severe psychological distress can aid clinicians in timely referring the patient, thereby enhancing survivorship care. (Source: Cancers)
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Nathalie Vanlaer Iris Dirven Bart Neyns Anne Rogiers Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1639: LINC01021 Attenuates Expression and Affects Alternative Splicing of a Subset of p53-Regulated Genes
Conclusions: Our results suggest that LINC01021 may restrict the extent and strength of p53-mediated transcriptional changes via context-dependent regulation of the expression and splicing of a subset of p53-regulated genes. (Source: Cancers)
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Kaller Forn é Imhof Hermeking Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1640: Histological Patterns and Mammographic Presentation of Invasive Lobular Carcinoma Show No Obvious Associations
őző
Invasive lobular carcinoma of the breast has different mammographic appearances, including spiculated or lobulated masses, architectural distortion, increased breast density, and the possibility of also being occult. Histologically, the morphology is also variable, as several patterns have been described beside the classical one, including the solid, the alveolar, the trabecular, the one with tubular elements, and others. Of 146 ILC cases, 141 were reviewed for mammographic appearance and 136 for histological patterns by two radiologist and two pathologists, respectively; 132 common cases were analyzed for possib...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: G ábor Cserni Rita Bori Éva Ambrózay Orsolya Serf őző Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1641: Detection and Real-Time Surgical Assessment of Colorectal Liver Metastases Using Near-Infrared Fluorescence Imaging during Laparoscopic and Robotic-Assisted Resections
Conclusions: ICG fluorescence imaging can be integrated with other conventional intraoperative imaging techniques to optimize intraoperative staging. Rim fluorescence proved to be a valid indicator of the resection margins: by removing the entire fluorescent area, a tumor-negative resection (R0) is achieved. (Source: Cancers)
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Piccolo Barabino Ghilardi Masserano Lecchi Piozzi Bianchi Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1642: Assessing the Effects of Curcumin and 450 nm Photodynamic Therapy on Oxidative Metabolism and Cell Cycle in Head and Neck Squamous Cell Carcinoma: An In Vitro Study
Andrea Amaroli
Oral cancer is the 16th most common malignant tumor worldwide. The risk of recurrence and mortality is high, and the survival rate is low over the following five years. Recent studies have shown that curcumin causes apoptosis in tumor cells by affecting FoF1-ATP synthase (ATP synthase) activity, which, in turn, hinders cell energy production, leading to a loss of cell viability. Additionally, irradiation of curcumin within cells can intensify its detrimental effects on cancer cell viability and proliferation (photodynamic therapy). We treated the OHSU-974 cell line, a model for human head and neck squam...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Silvia Ravera Claudio Pasquale Isabella Panfoli Matteo Bozzo Dimitrios Agas Silvia Bruno Michael R. Hamblin Andrea Amaroli Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1628: Peripheral Soluble Immune Checkpoint-Related Proteins Were Associated with Survival and Treatment Efficacy of Osteosarcoma Patients, a Cohort Study
Conclusion: Four soluble ICK-related proteins were associated with the survival of OS patients. Soluble ICK-related proteins could be promising biomarkers for the outcomes and immunotherapy of OS patients, though more research is warranted. (Source: Cancers)
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Binghao Li Qinchuan Wang Yihong Luo Sicong Wang Sai Pan Wenting Zhao Zhaoming Ye Xifeng Wu Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1629: Serum Proteomic Signatures in Cervical Cancer: Current Status and Future Directions
We report on identified multimarker panels of serum proteomic studies in CC for the past 5 years, the potential for modern computational biology efforts, and the utilization of nationwide biobanks to bridge the gap between multivariate protein signature development and the prediction of clinically relevant CC patient outcomes. (Source: Cancers)
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Chaston Weaver Alisha Nam Caitlin Settle Madelyn Overton Maya Giddens Katherine P. Richardson Rachael Piver David P. Mysona Bunja Rungruang Sharad Ghamande Richard McIndoe Sharad Purohit Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1627: Correction: Mathew et al. Metabolic Signature of Warburg Effect in Cancer: An Effective and Obligatory Interplay between Nutrient Transporters and Catabolic/Anabolic Pathways to Promote Tumor Growth. Cancers 2024, 16, 504
Ganapathy
In the original publication [...] (Source: Cancers)
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Marilyn Mathew Nhi T. Nguyen Yangzom D. Bhutia Sathish Sivaprakasam Vadivel Ganapathy Tags: Correction Source Type: research
