Subchronic co-exposure of polystyrene nanoplastics and 3-BHA significantly aggravated the reproductive toxicity of ovaries and uterus in female mice
Environ Pollut. 2024 May 4:124101. doi: 10.1016/j.envpol.2024.124101. Online ahead of print.ABSTRACTBoth nanoplastics (NPs) and 3-tert-butyl-4-hydroxyanisole (3-BHA) are environmental contaminants that can bio-accumulate through the food chain. However, the combined effects of which on mammalian female reproductive system remain unclear. Here, the female ICR-CD1 mice were used to evaluate the damage effects of ovaries and uterus after NPs and 3-BHA co-treatment for 35 days. Firstly, co-exposure significantly reduced the body weight and organ index of ovaries and uterus in mice. Secondly, combined effects of NPs and 3-BHA e...
Source: Environmental Pollution - May 6, 2024 Category: Environmental Health Authors: Guanghua Xiong Haiyan Zhang Yulin Peng Huangqi Shi Meiling Han Tianle Hu Hongcheng Wang Shangrong Zhang Xiaoqing Wu Gaoxiao Xu Jun'e Zhang Yong Liu Source Type: research
Gonadal Transcriptome Analysis Reveals that SOX17 and CYP26A1 are Involved in Sex Differentiation in the Chinese Soft-Shelled Turtle (Pelodiscus sinensis)
In this study, a comparative transcriptome analysis of male (ZZ)- and 17β-oestradiol (E2)-induced pseudo-female (ZZ + E2)-stage embryonic gonads of P. sinensis was performed. A total of 420 differentially expressed genes (DEGs), which included 271 upregulated genes and 149 downregulated genes, were identified. These DEGs were mainly involved in several sex-related pathways, such as "ovarian steroidogenesis", "steroid hormone biosynthesis", "PPAR signalling pathway", and "metabolism of xenobiotics by cytochrome P450". In addition, 50 known and novel candidate genes involved in sex differentiation, such as the male-biased g...
Source: Biochemical Genetics - May 6, 2024 Category: Genetics & Stem Cells Authors: Gang Wan Hui Zhang Pei Wang Qin Qin Xianwen Zhou Gang Xiong Xiaoqing Wang Yazhou Hu Source Type: research
Clinical and pathological features of ovarian microcystic stromal tumors: Report of two cases
Asian J Surg. 2024 May 6:S1015-9584(24)00803-0. doi: 10.1016/j.asjsur.2024.04.121. Online ahead of print.NO ABSTRACTPMID:38710604 | DOI:10.1016/j.asjsur.2024.04.121 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - May 6, 2024 Category: Surgery Authors: Li-Xia Lu Wen-Ying Yu Rong Ge Source Type: research
Factors contributing to variability in metformin concentration in polycystic ovary syndrome
CONCLUSIONS: This study highlights the critical role of BMI in influencing metformin pharmacokinetics in PCOS patients and underscores the need for personalized treatment strategies in patients with PCOS.PMID:38706239 (Source: Croatian Medical Journal)
Source: Croatian Medical Journal - May 6, 2024 Category: General Medicine Authors: Valentina N Nikoli ć Milan Stefanovi ć Dejan Miti ć Slavica Sunari ć Ma ša Jović Hristina Trajkovi ć Sanja Stankovi ć Aleksandra Ignjatovi ć Dragana Stokanovi ć Source Type: research
piR-1919609 Is an Ideal Potential Target for Reversing Platinum Resistance in Ovarian Cancer
CONCLUSION: In summary, we showed that piR-1919609 is involved in the regulation of drug resistance in ovarian cancer cells and might be an ideal potential target for reversing platinum resistance in ovarian cancer.PMID:38706262 | DOI:10.1177/15330338241249692 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - May 6, 2024 Category: Cancer & Oncology Authors: Ying Yan Dan Tian Bingbing Zhao Zhuang Li Zhijiong Huang Kuina Li Xiaoqi Chen Lu Zhou Yanying Feng Zhijun Yang Source Type: research
Intact cell mass spectrometry coupled with machine learning reveals minute changes induced by single gene silencing
Heliyon. 2024 Apr 22;10(9):e29936. doi: 10.1016/j.heliyon.2024.e29936. eCollection 2024 May 15.ABSTRACTIntact (whole) cell MALDI TOF mass spectrometry is a commonly used tool in clinical microbiology for several decades. Recently it was introduced to analysis of eukaryotic cells, including cancer and stem cells. Besides targeted metabolomic and proteomic applications, the intact cell MALDI TOF mass spectrometry provides a sufficient sensitivity and specificity to discriminate cell types, isogenous cell lines or even the metabolic states. This makes the intact cell MALDI TOF mass spectrometry a promising tool for quality co...
Source: Cancer Control - May 6, 2024 Category: Cancer & Oncology Authors: Luk áš Pečinka Luk áš Moráň Petra Kova čovicová Francesca Meloni Josef Havel Tiziana Pivetta Petr Va ňhara Source Type: research
piR-1919609 Is an Ideal Potential Target for Reversing Platinum Resistance in Ovarian Cancer
CONCLUSION: In summary, we showed that piR-1919609 is involved in the regulation of drug resistance in ovarian cancer cells and might be an ideal potential target for reversing platinum resistance in ovarian cancer.PMID:38706262 | DOI:10.1177/15330338241249692 (Source: Cell Research)
Source: Cell Research - May 6, 2024 Category: Cytology Authors: Ying Yan Dan Tian Bingbing Zhao Zhuang Li Zhijiong Huang Kuina Li Xiaoqi Chen Lu Zhou Yanying Feng Zhijun Yang Source Type: research
Gonadotropin elevation is ootoxic to ovulatory oocytes and inhibits oocyte maturation, and activin decoy receptor ActRIIB:Fc therapeutically restores maturation
Elevated FSH often occurs in women of advanced maternal age (AMA, age ≥ 35) and in infertility patients undergoing controlled ovarian stimulation (COS). There is controversy on whether high endogenous FSH cont... (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - May 6, 2024 Category: Endocrinology Authors: Lori R. Bernstein, Amelia C. L. Mackenzie, Charles L. Chaffin, Se-Jin Lee, Duane C. Kraemer and Istvan Merchenthaler Tags: Research Source Type: research
Prognostic factors and the role of primary debulking in operable stage IVB ovarian cancer with supraclavicular lymph node metastasis: a retrospective study in Chinese patients
This study aimed to explore the prognostic factors and the... (Source: BMC Cancer)
Source: BMC Cancer - May 6, 2024 Category: Cancer & Oncology Authors: Chenlian Quan, Xiaojun Chen, Hao Wen, Xiaohua Wu and Jin Li Tags: Research Source Type: research
miR-3653-3p Expression in PBMCs: Unveiling the Diagnostic Potential for Ovarian Cancer
Biochem Genet. 2024 May 5. doi: 10.1007/s10528-024-10819-0. Online ahead of print.ABSTRACTOvarian cancer is typically diagnosed at an advanced stage, recurs early and often, and currently lacks effective treatment. Therefore, overall survival and progression-free survival are relatively short for this disease. Sensitive and specific biomarkers for early diagnosis and follow-up for effective treatment of the disease are currently lacking. MicroRNA (miRNA/miR) expression studies are widely used in cancer research. Disruption or malfunction of miRNAs, a class of noncoding small RNAs, has been implicated in cancer progression ...
Source: Biochemical Genetics - May 5, 2024 Category: Genetics & Stem Cells Authors: Fatma Seher Pektopal Delek Şeref Buğra Tunçer Demet Akdeniz Ödemiş Seda K ılıç Erciyas Özge Şükrüoğlu Erdoğan P ınar Saip H ülya Yazıcı Source Type: research
Physical fitness in Indian women with epilepsy on anti-seizure medications and its association with reproductive status, quality of life and stigma: A cross-sectional study
CONCLUSION: WWE on polytherapy were physically less active, higher occurrence of reproductive abnormalities, and stigma compared to the monotherapy group. WWE with higher seizure frequency had poor physical fitness, and higher stigma compared to those with lesser number of seizures. These findings may aid value in optimization of ASM treatment in WWE of reproductive age.PMID:38704986 | DOI:10.1016/j.yebeh.2024.109823 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 5, 2024 Category: Neurology Authors: Soumya Sucharita Pattnaik Sudhir Chandra Sarangi Reeta Mahey Manjari Tripathi Source Type: research
miR-3653-3p Expression in PBMCs: Unveiling the Diagnostic Potential for Ovarian Cancer
Biochem Genet. 2024 May 5. doi: 10.1007/s10528-024-10819-0. Online ahead of print.ABSTRACTOvarian cancer is typically diagnosed at an advanced stage, recurs early and often, and currently lacks effective treatment. Therefore, overall survival and progression-free survival are relatively short for this disease. Sensitive and specific biomarkers for early diagnosis and follow-up for effective treatment of the disease are currently lacking. MicroRNA (miRNA/miR) expression studies are widely used in cancer research. Disruption or malfunction of miRNAs, a class of noncoding small RNAs, has been implicated in cancer progression ...
Source: Cancer Control - May 5, 2024 Category: Cancer & Oncology Authors: Fatma Seher Pektopal Delek Şeref Buğra Tunçer Demet Akdeniz Ödemiş Seda K ılıç Erciyas Özge Şükrüoğlu Erdoğan P ınar Saip H ülya Yazıcı Source Type: research
Cancers, Vol. 16, Pages 1781: Amplification of Hippo Signaling Pathway Genes Is Governed and Implicated in the Serous Subtype-Specific Ovarian Carcino-Genesis
This study examined the impact of Hippo signaling pathway on ovarian carcinogenesis. Therefore, the signatures related to Hippo signaling pathway were derived from the molecular signatures database (MSigDB) and were used for further analysis. The Z score-based pathway activation scoring method was employed to investigate the expression patterns of these signatures in the mRNA expression profiles of ovarian cancer cohorts. Compared to other subtype tumors, the results of this study show that the Hippo signaling pathway signatures are dysregulated prominently in serous subtype-specific ovarian carcinogenesis. A receiver oper...
Source: Cancers - May 5, 2024 Category: Cancer & Oncology Authors: Karthik Balakrishnan Yuanhong Chen Jixin Dong Tags: Article Source Type: research
A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development
Cell Metab. 2024 Apr 29:S1550-4131(24)00132-3. doi: 10.1016/j.cmet.2024.04.012. Online ahead of print.ABSTRACTThe mitochondrial genome transcribes 13 mRNAs coding for well-known proteins essential for oxidative phosphorylation. We demonstrate here that cytochrome b (CYTB), the only mitochondrial-DNA-encoded transcript among complex III, also encodes an unrecognized 187-amino-acid-long protein, CYTB-187AA, using the standard genetic code of cytosolic ribosomes rather than the mitochondrial genetic code. After validating the existence of this mtDNA-encoded protein arising from cytosolic translation (mPACT) using mass spectro...
Source: Cell Metabolism - May 4, 2024 Category: Cytology Authors: Zhijuan Hu Liang Yang Maolei Zhang Haite Tang Yile Huang Yujie Su Yingzhe Ding Chong Li Mengfei Wang Yunhao Zhou Qing Zhang Liman Guo Yue Wu Qianqian Wang Ning Liu Haoran Kang Yi Wu Deyang Yao Yukun Li Zifeng Ruan Hao Wang Feixiang Bao Guopan Liu Junwei W Source Type: research
Diversity and Functionality of Bacteria Associated with Different Tissues of Spider Heteropoda venatoria Revealed through Integration of High-Throughput Sequencing and Culturomics Approaches
This study aimed to investigate the community diversity and functional characteristics of spider-associated bacteria in four tissues of Heteropoda venatoria using HTS of the 16S rRNA gene and culturomics technologies, as well as the functional verification of the isolated strains. The results of HTS showed that the spider-associated bacteria in different tissues belonged to 34 phyla, 72 classes, 170 orders, 277 families, and 458 genera. Bacillus was found to be the most abundant bacteria in the venom gland, silk gland, and ovary, while Stenotrophomonas, Acinetobacter, and Sphingomonas were dominant in the gut microbiota. B...
Source: Microbial Ecology - May 4, 2024 Category: Microbiology Authors: Likun Zhao Shanfeng Zhang Ruoyi Xiao Chao Zhang Zhitang Lyu Feng Zhang Source Type: research
