Associations between Hysterectomy and Metabolic Syndrome: The Multi-Ethnic Study of Atherosclerosis
CONCLUSION: Hysterectomy, even with ovarian preservation, may be independently associated with a higher risk of metabolic syndrome. If other studies confirm these findings, screening and preventive strategies focused on females with ovary-sparing hysterectomy and the mechanisms underpinning these associations may be explored.PMID:38703940 | DOI:10.1016/j.ajog.2024.04.035 (Source: Atherosclerosis)
Source: Atherosclerosis - May 4, 2024 Category: Cardiology Authors: Eric K Broni Justin B Echouffo Tcheugui Anna Palatnik Ernest M Graham Ruth-Alma Turkson-Ocran Yvonne Commodore-Mendah Chiadi E Ndumele Erin D Michos Source Type: research
Correspondence on "Expanding the Use of HIPEC in Ovarian Cancer at Interval Debulking Surgery to FIGO Stage IV and After 6 Cycles of Neoadjuvant Chemotherapy: A Prospective Analysis and Perioperative and Oncologic Outcomes" by Valentina Ghirardi et al
Ann Surg Oncol. 2024 May 4. doi: 10.1245/s10434-024-15399-2. Online ahead of print.NO ABSTRACTPMID:38704500 | DOI:10.1245/s10434-024-15399-2 (Source: Ann Oncol)
Source: Ann Oncol - May 4, 2024 Category: Cancer & Oncology Authors: Mukurdipi Ray V Carolin Solomi Source Type: research
Angelica sinensis polysaccharide combined with cisplatin reverses cisplatin resistance of ovarian cancer by inducing ferroptosis via regulating GPX4
Biomed Pharmacother. 2024 May 3;175:116680. doi: 10.1016/j.biopha.2024.116680. Online ahead of print.ABSTRACTCisplatin (DDP) resistance poses a significant challenge in the treatment of ovarian cancer. Studies have shown that the combination of certain polysaccharides derived from plants with DDP is an effective approach to overcoming drug resistance in some cancers. Angelica sinensis (Oliv.) Diels has been used for centuries in China to treat gynecological ailments. Numerous studies indicate that Angelica sinensis polysaccharide (ASP), an extract from Angelica sinensis, can inhibit various forms of cancer. However, the im...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 4, 2024 Category: Drugs & Pharmacology Authors: Weikang Guo Wanyue Wang Fei Lei Ruxin Zheng Xinyao Zhao Yuze Gu Mengdi Yang Yunshun Tong Yaoxian Wang Source Type: research
NB compounds are potent and efficacious FOXM1 inhibitors in high-grade serous ovarian cancer cells
CONCLUSIONS: NB compounds are potent, selective, and efficacious inhibitors of FOXM1 in HGSOC cells and are worthy of further investigation as HGSOC therapeutics.PMID:38704607 | DOI:10.1186/s13048-024-01421-4 (Source: Cell Research)
Source: Cell Research - May 4, 2024 Category: Cytology Authors: Cassie Liu Makenzie Vorderbruggen Catalina Mu ñoz-Trujillo Sung Hoon Kim John A Katzenellenbogen Benita S Katzenellenbogen Adam R Karpf Source Type: research
A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development
Cell Metab. 2024 Apr 29:S1550-4131(24)00132-3. doi: 10.1016/j.cmet.2024.04.012. Online ahead of print.ABSTRACTThe mitochondrial genome transcribes 13 mRNAs coding for well-known proteins essential for oxidative phosphorylation. We demonstrate here that cytochrome b (CYTB), the only mitochondrial-DNA-encoded transcript among complex III, also encodes an unrecognized 187-amino-acid-long protein, CYTB-187AA, using the standard genetic code of cytosolic ribosomes rather than the mitochondrial genetic code. After validating the existence of this mtDNA-encoded protein arising from cytosolic translation (mPACT) using mass spectro...
Source: Cell Metabolism - May 4, 2024 Category: Cytology Authors: Zhijuan Hu Liang Yang Maolei Zhang Haite Tang Yile Huang Yujie Su Yingzhe Ding Chong Li Mengfei Wang Yunhao Zhou Qing Zhang Liman Guo Yue Wu Qianqian Wang Ning Liu Haoran Kang Yi Wu Deyang Yao Yukun Li Zifeng Ruan Hao Wang Feixiang Bao Guopan Liu Junwei W Source Type: research
Diversity and Functionality of Bacteria Associated with Different Tissues of Spider Heteropoda venatoria Revealed through Integration of High-Throughput Sequencing and Culturomics Approaches
This study aimed to investigate the community diversity and functional characteristics of spider-associated bacteria in four tissues of Heteropoda venatoria using HTS of the 16S rRNA gene and culturomics technologies, as well as the functional verification of the isolated strains. The results of HTS showed that the spider-associated bacteria in different tissues belonged to 34 phyla, 72 classes, 170 orders, 277 families, and 458 genera. Bacillus was found to be the most abundant bacteria in the venom gland, silk gland, and ovary, while Stenotrophomonas, Acinetobacter, and Sphingomonas were dominant in the gut microbiota. B...
Source: Microbial Ecology - May 4, 2024 Category: Microbiology Authors: Likun Zhao Shanfeng Zhang Ruoyi Xiao Chao Zhang Zhitang Lyu Feng Zhang Source Type: research
Reproductive and endocrine-disrupting toxicity of Pyrogallol in catfish (Clarias gariepinus)
Environ Pollut. 2024 May 2:124104. doi: 10.1016/j.envpol.2024.124104. Online ahead of print.ABSTRACTEndocrine disruptors are synthetic or natural chemicals that can agonize/antagonize hormone receptors or can interfere with the production and secretion of hormones, leading to altered tissue histology and physiology. Pyrogallol is a contaminant widely distributed in aquatic environments that presents health risks to both humans and animals. However, the potential for endocrine disruption by pyrogallol, particularly in fish, are lacking. The purpose of this study was to shed light on how pyrogallol may affect hormone signall...
Source: Environmental Pollution - May 4, 2024 Category: Environmental Health Authors: Mohamed Hamed Rashad E M Said Christopher J Martyniuk Hamdy A M Soliman Alaa El-Din H Sayed Alaa G M Osman Source Type: research
Risk of gestational diabetes in women with PCOS based on body mass index: The Japan Environment and Children's Study
CONCLUSIONS: The impact of PCOS on GDM occurrence depended on the pre-pregnancy BMIs, which may facilitate personalized preconception counseling among women with PCOS.PMID:38703083 | DOI:10.1210/clinem/dgae293 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 4, 2024 Category: Endocrinology Authors: Chihiro Okoshi Hyo Kyozuka Toma Fukuda Shun Yasuda Tsuyoshi Murata Hirotaka Isogami Akiko Sato Yuka Ogata Mitsuaki Hosoya Seiji Yasumura Koichi Hashimoto Hidekazu Nishigori Michihiro Kamijima Shin Yamazaki Yukihiro Ohya Reiko Kishi Nobuo Yaegashi Chisato Source Type: research
Angelica sinensis polysaccharide combined with cisplatin reverses cisplatin resistance of ovarian cancer by inducing ferroptosis via regulating GPX4
Biomed Pharmacother. 2024 May 3;175:116680. doi: 10.1016/j.biopha.2024.116680. Online ahead of print.ABSTRACTCisplatin (DDP) resistance poses a significant challenge in the treatment of ovarian cancer. Studies have shown that the combination of certain polysaccharides derived from plants with DDP is an effective approach to overcoming drug resistance in some cancers. Angelica sinensis (Oliv.) Diels has been used for centuries in China to treat gynecological ailments. Numerous studies indicate that Angelica sinensis polysaccharide (ASP), an extract from Angelica sinensis, can inhibit various forms of cancer. However, the im...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 4, 2024 Category: Drugs & Pharmacology Authors: Weikang Guo Wanyue Wang Fei Lei Ruxin Zheng Xinyao Zhao Yuze Gu Mengdi Yang Yunshun Tong Yaoxian Wang Source Type: research
Correspondence on "Expanding the Use of HIPEC in Ovarian Cancer at Interval Debulking Surgery to FIGO Stage IV and After 6 Cycles of Neoadjuvant Chemotherapy: A Prospective Analysis and Perioperative and Oncologic Outcomes" by Valentina Ghirardi et al
Ann Surg Oncol. 2024 May 4. doi: 10.1245/s10434-024-15399-2. Online ahead of print.NO ABSTRACTPMID:38704500 | DOI:10.1245/s10434-024-15399-2 (Source: Ann Oncol)
Source: Ann Oncol - May 4, 2024 Category: Cancer & Oncology Authors: Mukurdipi Ray V Carolin Solomi Source Type: research
Associations between Hysterectomy and Metabolic Syndrome: The Multi-Ethnic Study of Atherosclerosis
CONCLUSION: Hysterectomy, even with ovarian preservation, may be independently associated with a higher risk of metabolic syndrome. If other studies confirm these findings, screening and preventive strategies focused on females with ovary-sparing hysterectomy and the mechanisms underpinning these associations may be explored.PMID:38703940 | DOI:10.1016/j.ajog.2024.04.035 (Source: Atherosclerosis)
Source: Atherosclerosis - May 4, 2024 Category: Cardiology Authors: Eric K Broni Justin B Echouffo Tcheugui Anna Palatnik Ernest M Graham Ruth-Alma Turkson-Ocran Yvonne Commodore-Mendah Chiadi E Ndumele Erin D Michos Source Type: research
Perioperative management of a patient with unexpectedly detected early-stage ovarian mucinous carcinoma combined with progressive bulbar paralysis: a case report and literature review
Giant ovarian cysts (GOCs)complicated with progressive bulbar paralysis (PBP) are very rare, and no such literature about these cases have been reported. Through the diagnosis and treatment of this case, the p... (Source: BMC Women's Health)
Source: BMC Women's Health - May 4, 2024 Category: OBGYN Authors: Dingbei Zhang, Ruibo Xu, Tingting Huo, Ying Liu, Zengfang Hao, Yao Sun, Xiaoyu Xi, Xiaoli Du, Lili Wang and Jiexian Du Tags: Case Report Source Type: research
Comparing niraparib versus platinum-taxane doublet chemotherapy as neoadjuvant treatment in patients with newly diagnosed homologous recombination –deficient stage III/IV ovarian cancer: study protocol for cohort C of the open-label, phase 2, randomized controlled multicenter OPAL trial
Maintenance therapy with niraparib, a poly(ADP-ribose) polymerase inhibitor, has been shown to extend progression-free survival in patients with newly diagnosed advanced ovarian cancer who responded to first-l... (Source: Trials)
Source: Trials - May 4, 2024 Category: General Medicine Authors: Jimmy Belotte, Brunella Felicetti, Amanda J. Baines, Ahmed YoussefAgha, Luis Rojas-Espaillat, Ana Godoy Ortiz, Diane Provencher, Ra úl Márquez Vázquez, Lucia González Cortijo and Xing Zeng Tags: Study protocol Source Type: research
Predictors of Blood Transfusion in Patients Undergoing Cytoreductive Surgeries for Ovarian Malignancy
CONCLUSIONS: Perioperative blood transfusion is common in patients undergoing cytoreductive surgery. In this study, EBL and preoperative hemoglobin levels were significantly associated with transfusion receipt. Clinicians should optimize hemoglobin levels and intraoperative blood conservation strategies to reduce the need for transfusion. The results also highlight the importance of considering racial and ethnic differences when developing strategies to reduce transfusion risk.PMID:38701848 | PMC:PMC11073803 | DOI:10.14423/SMJ.0000000000001685 (Source: Southern Medical Journal)
Source: Southern Medical Journal - May 3, 2024 Category: General Medicine Authors: Janina V Pearce Jinlei Zhao Leslie Randall Stephanie A Sullivan Devin Miller Katherine Tossas Source Type: research
Pseudogestational Sac Delaying Diagnosis of Ectopic Pregnancy: A Case Report
We present a case of a 20-year-old woman who arrived to the Emergency Department (ED) with abdominal pain and ended up being transferred for an Obstetrics evaluation of a possible heterotopic pregnancy. Her radiology-performed ultrasound had revealed an "intrauterine gestational sac" along with an adnexal mass near the right ovary. The patient was not undergoing assisted-reproductive fertilization, nor did she have meaningful risk factors for heterotopic pregnancy. The patient was managed expectantly over the ensuing week to see whether the intrauterine fluid was a true gestational sac. After multiple repeat ED visits, the...
Source: Pain Physician - May 3, 2024 Category: Anesthesiology Authors: Maya Fontenot Jake Valentine Source Type: research
