The importance of developmental programming in the beef industry
Anim Reprod Sci. 2024 Apr 26;265:107488. doi: 10.1016/j.anireprosci.2024.107488. Online ahead of print.ABSTRACTThe beef industry relies on multiple focused segments (e.g., cow-calf, stocker/feeder, and meat packing) to supply the world with beef. Thus, the potential impact of developmental programming on the beef industry needs to be evaluated with regards to the different production traits that drive profitability within each segment. For example, when nutrient restriction of dams occurred early in gestation embryo survival was decreased and the ovarian reserve of heifer progeny was negatively affected. Restriction during...
Source: Animal Reproduction Science - May 3, 2024 Category: Zoology Authors: George A Perry Thomas H Welsh Source Type: research
Bisphenol A and its structural analogues exhibit differential potential to induce mitochondrial dysfunction and apoptosis in human granulosa cells
This study evaluated the effects of BPA and its analogues BPS, BPF, and BPAF on the mitochondrial mass and function, oxidative stress, and their potential to induce apoptosis of human granulosa cells (KGN cells). BPA and its analogues, especially BPA and BPAF, significantly decreased mitochondrial activity and cell viability. The potential of bisphenols to reduce mitochondrial mass and function differed in the following order: BPAF > BPA > BPF > BPS. Flow cytometry revealed that exposure to bisphenols significantly increased mitochondrial ROS levels and increased mitochondrial Ca2+ levels. Thus, bisphenols exposur...
Source: Food and Chemical Toxicology - May 3, 2024 Category: Food Science Authors: Guofeng Xu Mingquan Huang Jun Hu Shuang Liu Meng Yang Source Type: research
Persistent organic pollutants dysregulate energy homeostasis in human ovaries in vitro
In conclusion, our results demonstrate the disruption of cellular energy metabolism as a novel mode of action underlying POP-mediated interference of follicle growth in human ovaries.PMID:38701644 | DOI:10.1016/j.envint.2024.108710 (Source: Environment International)
Source: Environment International - May 3, 2024 Category: Environmental Health Authors: Tianyi Li Richelle D Bj örvang Jie Hao Valentina Di Nisio Anastasios Damdimopoulos Cecilia Lindskog Kiriaki Papaikonomou Pauliina Damdimopoulou Source Type: research
Ovarian reserve in patients with FMR1 gene premutation and the role of fertility preservation
CONCLUSIONS: This study shows the importance of early fertility preservation after diagnosis of FMR1 premutation in women, due to early deterioration of ovarian reserve. Genetic counseling is essential in these patients, as spontaneous pregnancies are not uncommon, even in cases of impaired ovarian reserve, and can lead to birth of affected children.PMID:38702011 | DOI:10.1016/j.ando.2024.04.004 (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - May 3, 2024 Category: Endocrinology Authors: Tiphaine Le Poulennec Sophie Dubreuil Michael Grynberg Nathalie Chabbert-Buffet Nathalie Sermondade Salma Fourati Jean-Pierre Siffroi Delphine H éron Anne Bachelot Source Type: research
Association of glucagon-like peptide-1 receptor agonists with risk of cancers-evidence from a drug target Mendelian randomization and clinical trials
CONCLUSIONS: Our study suggests that GLP1RA may decrease the risk of breast cancer and basal cell carcinoma, but increase the risk of colorectal cancer. However, according to the systematic review of RCTs, the incidence of cancer in patients treated with GLP1RA is low. Larger sample sizes of RCTs with long-term follow-up are necessary to establish the incidence of cancers and evaluate the risk-benefit ratios.PMID:38701500 | DOI:10.1097/JS9.0000000000001514 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Yuming Sun Yongjia Liu Yating Dian Furong Zeng Guangtong Deng Shaorong Lei Source Type: research
Efficacy and safety of PD-1/PD-L1 immune checkpoint inhibitors in the treatment of recurrent ovarian cancer: A systematic review and meta-analysis
CONCLUSIONS: PD-1/PD-L1 inhibitors offer a promising treatment option for recurrent OC, improving ORR, DCR, and PFS. However, the higher incidence of adverse events necessitates a cautious approach to their use. Future research should focus on long-term outcomes, biomarker identification, and optimal combination therapies.PMID:38701316 | DOI:10.1097/MD.0000000000038019 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Yafang Chen Xiaomei Liu Ying Hu Lingling Xia Source Type: research
Pseudogestational Sac Delaying Diagnosis of Ectopic Pregnancy: A Case Report
We present a case of a 20-year-old woman who arrived to the Emergency Department (ED) with abdominal pain and ended up being transferred for an Obstetrics evaluation of a possible heterotopic pregnancy. Her radiology-performed ultrasound had revealed an "intrauterine gestational sac" along with an adnexal mass near the right ovary. The patient was not undergoing assisted-reproductive fertilization, nor did she have meaningful risk factors for heterotopic pregnancy. The patient was managed expectantly over the ensuing week to see whether the intrauterine fluid was a true gestational sac. After multiple repeat ED visits, the...
Source: Pain Physician - May 3, 2024 Category: Anesthesiology Authors: Maya Fontenot Jake Valentine Source Type: research
Bisphenol A and its structural analogues exhibit differential potential to induce mitochondrial dysfunction and apoptosis in human granulosa cells
This study evaluated the effects of BPA and its analogues BPS, BPF, and BPAF on the mitochondrial mass and function, oxidative stress, and their potential to induce apoptosis of human granulosa cells (KGN cells). BPA and its analogues, especially BPA and BPAF, significantly decreased mitochondrial activity and cell viability. The potential of bisphenols to reduce mitochondrial mass and function differed in the following order: BPAF > BPA > BPF > BPS. Flow cytometry revealed that exposure to bisphenols significantly increased mitochondrial ROS levels and increased mitochondrial Ca2+ levels. Thus, bisphenols exposur...
Source: Food and Chemical Toxicology - May 3, 2024 Category: Food Science Authors: Guofeng Xu Mingquan Huang Jun Hu Shuang Liu Meng Yang Source Type: research
The importance of developmental programming in the beef industry
Anim Reprod Sci. 2024 Apr 26;265:107488. doi: 10.1016/j.anireprosci.2024.107488. Online ahead of print.ABSTRACTThe beef industry relies on multiple focused segments (e.g., cow-calf, stocker/feeder, and meat packing) to supply the world with beef. Thus, the potential impact of developmental programming on the beef industry needs to be evaluated with regards to the different production traits that drive profitability within each segment. For example, when nutrient restriction of dams occurred early in gestation embryo survival was decreased and the ovarian reserve of heifer progeny was negatively affected. Restriction during...
Source: Animal Reproduction Science - May 3, 2024 Category: Zoology Authors: George A Perry Thomas H Welsh Source Type: research
Predictors of Blood Transfusion in Patients Undergoing Cytoreductive Surgeries for Ovarian Malignancy
CONCLUSIONS: Perioperative blood transfusion is common in patients undergoing cytoreductive surgery. In this study, EBL and preoperative hemoglobin levels were significantly associated with transfusion receipt. Clinicians should optimize hemoglobin levels and intraoperative blood conservation strategies to reduce the need for transfusion. The results also highlight the importance of considering racial and ethnic differences when developing strategies to reduce transfusion risk.PMID:38701848 | DOI:10.14423/SMJ.0000000000001685 (Source: Southern Medical Journal)
Source: Southern Medical Journal - May 3, 2024 Category: General Medicine Authors: Janina V Pearce Jinlei Zhao Leslie Randall Stephanie A Sullivan Devin Miller Katherine Tossas Source Type: research
Persistent organic pollutants dysregulate energy homeostasis in human ovaries in vitro
In conclusion, our results demonstrate the disruption of cellular energy metabolism as a novel mode of action underlying POP-mediated interference of follicle growth in human ovaries.PMID:38701644 | DOI:10.1016/j.envint.2024.108710 (Source: Environment International)
Source: Environment International - May 3, 2024 Category: Environmental Health Authors: Tianyi Li Richelle D Bj örvang Jie Hao Valentina Di Nisio Anastasios Damdimopoulos Cecilia Lindskog Kiriaki Papaikonomou Pauliina Damdimopoulou Source Type: research
Association of glucagon-like peptide-1 receptor agonists with risk of cancers-evidence from a drug target Mendelian randomization and clinical trials
CONCLUSIONS: Our study suggests that GLP1RA may decrease the risk of breast cancer and basal cell carcinoma, but increase the risk of colorectal cancer. However, according to the systematic review of RCTs, the incidence of cancer in patients treated with GLP1RA is low. Larger sample sizes of RCTs with long-term follow-up are necessary to establish the incidence of cancers and evaluate the risk-benefit ratios.PMID:38701500 | DOI:10.1097/JS9.0000000000001514 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Yuming Sun Yongjia Liu Yating Dian Furong Zeng Guangtong Deng Shaorong Lei Source Type: research
Efficacy and safety of PD-1/PD-L1 immune checkpoint inhibitors in the treatment of recurrent ovarian cancer: A systematic review and meta-analysis
CONCLUSIONS: PD-1/PD-L1 inhibitors offer a promising treatment option for recurrent OC, improving ORR, DCR, and PFS. However, the higher incidence of adverse events necessitates a cautious approach to their use. Future research should focus on long-term outcomes, biomarker identification, and optimal combination therapies.PMID:38701316 | DOI:10.1097/MD.0000000000038019 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Yafang Chen Xiaomei Liu Ying Hu Lingling Xia Source Type: research
GSE252776 Persistent organic pollutants dysregulate energy homeostasis in human ovaries in vitro
In conclusion, our results demonstrate the d isruption of cellular energy metabolism as a novel mode of action underlying POP-mediated interference of follicle growth in human ovaries. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 3, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research
Successful Transvaginal Oocyte Retrieval following Laparoscopic Management of Tubal Pregnancy
A 28-year-old female with primary infertility, had a history of unilateral fallopian tube infection with tuberculosis had a first IVF cycle with poor ovarian response. In a second cycle, a progestin-primed ovarian stimulation (PPOS) protocol was chosen. On day 13, she experienced lower abdominal distension, with serology showing an estradiol of 4495.1 pg/ml, progesterone of 2.3 ng/ml, TVUS identified 12 follicles> 14 mm. Additionally, an echoic mass 3.2 ×2.3×2.5 cm adjacent to the right ovary, was demonstrated, raising suspicion of ectopic pregnancy, confirmed by an hCG levels of 81.9 mIU/ml. (Source: The Journal of Mini...
Source: The Journal of Minimally Invasive Gynecology - May 3, 2024 Category: OBGYN Authors: Sha-Wei Sa, Xiao-Yong Qiao, Jin-cheng Zhang, Qian-Hong Ma Tags: Images in Gynecologic Surgery Source Type: research
