Stereotactic body radiotherapy with or without selective dismutase mimetic in pancreatic adenocarcinoma: an adaptive, randomised, double-blind, placebo-controlled, phase 1b/2 trial
This study is registered with ClinicalTrials.gov, NCT03340974, and is complete.FINDINGS: Between Jan 25, 2018, and April 29, 2020, 47 patients were screened, of whom 42 were enrolled (median age was 71 years [IQR 63-75], 23 [55%] were male, 19 [45%] were female, 37 [88%] were White, three [7%] were Black, and one [2%] each were unknown or other races) and randomly assigned to avasopasem (n=24) or placebo (n=18); the placebo group was terminated early after failing to meet prespecified efficacy parameters. At data cutoff (June 28, 2021), the avasopasem group satisfied boundaries for both efficacy and toxicity. Late onset Ef...
Source: Pain Physician - December 1, 2023 Category: Anesthesiology Authors: Cullen M Taniguchi Jessica M Frakes Todd A Aguilera Manisha Palta Brian Czito Manoop S Bhutani Lauren E Colbert Joseph Abi Jaoude Vincent Bernard Shubham Pant Ching-Wei D Tzeng Dae Won Kim Mokenge Malafa James Costello Geena Mathew Neal Rebueno Eugene J K Source Type: research
ACR Appropriateness Criteria ® Acute Onset Flank Pain-Suspicion of Stone Disease (Urolithiasis)
J Am Coll Radiol. 2023 Nov;20(11S):S315-S328. doi: 10.1016/j.jacr.2023.08.020.ABSTRACTNoncontrast CT (NCCT) is the imaging study of choice for initial evaluation of patients with acute onset of flank pain and suspicion of stone disease without known prior stone disease. NCCT can reliably characterize the location and size of an offending ureteral calculus, identify complications, and diagnose alternative etiologies of abdominal pain. Although less sensitive in the detection of stones, ultrasound may have a role in evaluating for signs of obstruction. Radiography potentially has a role, although has been shown to be less se...
Source: Pain Physician - December 1, 2023 Category: Anesthesiology Authors: Expert Panel on Urological Imaging Rajan T Gupta Kevin Kalisz Gaurav Khatri Melanie P Caserta Tara M Catanzano Silvia D Chang Alberto Diaz De Leon John L Gore Refky Nicola Anand M Prabhakar Stephen J Savage Kevin P Shah Venkateswar R Surabhi Myles T Taffe Source Type: research
ACR Appropriateness Criteria ® Imaging After Total Knee Arthroplasty: 2023 Update
J Am Coll Radiol. 2023 Nov;20(11S):S433-S454. doi: 10.1016/j.jacr.2023.08.014.ABSTRACTTotal knee arthroplasty is the most commonly performed joint replacement procedure in the United States. This manuscript will discuss the recommended imaging modalities for six clinical variants; 1. follow-up of symptomatic or asymptomatic patients with a total knee arthroplasty. Initial imaging, 2. Suspected infection after total knee arthroplasty. Additional imaging following radiographs, 3. Pain after total knee arthroplasty. Infection excluded. Suspect aseptic loosening or osteolysis or instability. Additional imaging following radiog...
Source: Pain Physician - December 1, 2023 Category: Anesthesiology Authors: Expert Panel on Musculoskeletal Imaging Eric A Walker Michael G Fox Donna G Blankenbaker Cristy N French Matthew A Frick Tarek N Hanna Shari T Jawetz Cayce Onks Nicholas Said J Derek Stensby Francesca D Beaman Source Type: research
ACR Appropriateness Criteria ® Left Lower Quadrant Pain: 2023 Update
J Am Coll Radiol. 2023 Nov;20(11S):S471-S480. doi: 10.1016/j.jacr.2023.08.013.ABSTRACTThe differential diagnosis for left lower quadrant pain is wide and conditions range from the benign and self-limited to life-threatening surgical emergencies. Along with patient history, physical examination, and laboratory tests, imaging is often critical to limit the differential diagnosis and identify life-threatening abnormalities. This document will discuss the guidelines for the appropriate use of imaging in the initial workup for patients who present with left lower quadrant pain, patients with suspected diverticulitis, and patien...
Source: Pain Physician - December 1, 2023 Category: Anesthesiology Authors: Expert Panel on Gastrointestinal Imaging Stefanie Weinstein David H Kim Kathryn J Fowler James H Birkholz Brooks D Cash Elizabeth Cilenti Bari Dane Natally Horvat Avinash R Kambadakone Elena K Korngold Peter S Liu Bruce M Lo Marion McCrary Vincent Mellnic Source Type: research
Visualising, navigating and making time: The use of a digital solution in treatment and rehabilitation from low back pain
This study seeks to investigate relationships between digital technologies, temporal agency, and illness, through describing how users experienced a new digital solution, BackTrace, targeting patients with low back pain. The study builds on six months of ethnographic fieldwork, including semi-structured interviews, participant observation and a workshop. The study shows how the introduction of the digital solution could facilitate new possibilities of temporal actions for individuals living with and receiving care for low back pain. For many research participants, the use of BackTrace facilitated a useful visualisation of ...
Source: Pain Physician - November 30, 2023 Category: Anesthesiology Authors: Charlotte Ettrup Christiansen Mette Terp H øybye Ronja Rosenberg Gr øn Camilla Blach Rossen Source Type: research
Efficacy and safety of high-intensity, high-frequency, non-focused ultrasound parallel beams for facial skin laxity
CONCLUSION: The novel ultrasound device that uses high-intensity, high-frequency, non-focused ultrasound parallel beam was shown to improve safely and efficiently facial lax skin resulting in eyebrow, submental, and neck skin lift while experiencing tolerable pain.PMID:38031530 | DOI:10.1111/jocd.16098 (Source: Pain Physician)
Source: Pain Physician - November 30, 2023 Category: Anesthesiology Authors: Michael H Gold Julie Biron Source Type: research
Effect of osteopathic manipulative treatment and Bio-Electro-Magnetic Energy Regulation (BEMER) therapy on generalized musculoskeletal neck pain in adults
CONCLUSIONS: Study arms that incorporated BEMER yielded improvements on the NDI, VAS, and SF-12, indicating benefits to BEMER regarding improved overall functionality in routine daily activities as well as a reduction in nonspecific neck pain. Perceived pain, as demonstrated on the VAS, was seemingly improved in an additive fashion from the BEMER group to the OMT+BEMER group, although the results did not achieve statistical significance. Further study with greater participation could provide additional insight.PMID:38033194 | DOI:10.1515/jom-2023-0128 (Source: Pain Physician)
Source: Pain Physician - November 30, 2023 Category: Anesthesiology Authors: Genevieve M Palmer Nicholas Dominick Melissa Kane Sawyer Bawek Blake Burch Taylor Sanders Davong Phrathep Nicole Myers Santiago Lorenzo Source Type: research
Visualising, navigating and making time: The use of a digital solution in treatment and rehabilitation from low back pain
This study seeks to investigate relationships between digital technologies, temporal agency, and illness, through describing how users experienced a new digital solution, BackTrace, targeting patients with low back pain. The study builds on six months of ethnographic fieldwork, including semi-structured interviews, participant observation and a workshop. The study shows how the introduction of the digital solution could facilitate new possibilities of temporal actions for individuals living with and receiving care for low back pain. For many research participants, the use of BackTrace facilitated a useful visualisation of ...
Source: Pain Physician - November 30, 2023 Category: Anesthesiology Authors: Charlotte Ettrup Christiansen Mette Terp H øybye Ronja Rosenberg Gr øn Camilla Blach Rossen Source Type: research
Efficacy and safety of high-intensity, high-frequency, non-focused ultrasound parallel beams for facial skin laxity
CONCLUSION: The novel ultrasound device that uses high-intensity, high-frequency, non-focused ultrasound parallel beam was shown to improve safely and efficiently facial lax skin resulting in eyebrow, submental, and neck skin lift while experiencing tolerable pain.PMID:38031530 | DOI:10.1111/jocd.16098 (Source: Pain Physician)
Source: Pain Physician - November 30, 2023 Category: Anesthesiology Authors: Michael H Gold Julie Biron Source Type: research
Effect of osteopathic manipulative treatment and Bio-Electro-Magnetic Energy Regulation (BEMER) therapy on generalized musculoskeletal neck pain in adults
CONCLUSIONS: Study arms that incorporated BEMER yielded improvements on the NDI, VAS, and SF-12, indicating benefits to BEMER regarding improved overall functionality in routine daily activities as well as a reduction in nonspecific neck pain. Perceived pain, as demonstrated on the VAS, was seemingly improved in an additive fashion from the BEMER group to the OMT+BEMER group, although the results did not achieve statistical significance. Further study with greater participation could provide additional insight.PMID:38033194 | DOI:10.1515/jom-2023-0128 (Source: Pain Physician)
Source: Pain Physician - November 30, 2023 Category: Anesthesiology Authors: Genevieve M Palmer Nicholas Dominick Melissa Kane Sawyer Bawek Blake Burch Taylor Sanders Davong Phrathep Nicole Myers Santiago Lorenzo Source Type: research
Visualising, navigating and making time: The use of a digital solution in treatment and rehabilitation from low back pain
This study seeks to investigate relationships between digital technologies, temporal agency, and illness, through describing how users experienced a new digital solution, BackTrace, targeting patients with low back pain. The study builds on six months of ethnographic fieldwork, including semi-structured interviews, participant observation and a workshop. The study shows how the introduction of the digital solution could facilitate new possibilities of temporal actions for individuals living with and receiving care for low back pain. For many research participants, the use of BackTrace facilitated a useful visualisation of ...
Source: Pain Physician - November 30, 2023 Category: Anesthesiology Authors: Charlotte Ettrup Christiansen Mette Terp H øybye Ronja Rosenberg Gr øn Camilla Blach Rossen Source Type: research
Efficacy and safety of high-intensity, high-frequency, non-focused ultrasound parallel beams for facial skin laxity
CONCLUSION: The novel ultrasound device that uses high-intensity, high-frequency, non-focused ultrasound parallel beam was shown to improve safely and efficiently facial lax skin resulting in eyebrow, submental, and neck skin lift while experiencing tolerable pain.PMID:38031530 | DOI:10.1111/jocd.16098 (Source: Pain Physician)
Source: Pain Physician - November 30, 2023 Category: Anesthesiology Authors: Michael H Gold Julie Biron Source Type: research
Managing Complex Wounds in Skilled Nursing Facilities (SNFs)
Cureus. 2023 Oct 24;15(10):e47581. doi: 10.7759/cureus.47581. eCollection 2023 Oct.ABSTRACTWounds, especially chronic wounds, can be clinically challenging to manage. The presence of a chronic wound in a patient can not only cause nociceptive pain but also psychological and emotional pain. In extreme cases, they can be life-threatening if they present with infection and sepsis from poor wound care. This paper highlights the care of a patient in a skilled nursing facility who presented with a very complicated post-surgical abdominal wound, secondary to an infected post-surgical incision. The skilled nursing facility was ver...
Source: Pain Physician - November 29, 2023 Category: Anesthesiology Authors: James Ebot Source Type: research
Physician Trainees' Perception of Cannabidiol Use in Medicine: A Survey Study
CONCLUSION: The trajectory of CBD use in the United States indicates that the therapeutic benefits of CBD will be targeted, and future physicians are not always provided adequate educational opportunities to learn about its potential medical uses. Continued training as well as interactions with patients may help decrease the stigma surrounding medical CBD use and help solidify its therapeutic use in pain control.PMID:38022327 | PMC:PMC10653979 | DOI:10.7759/cureus.47228 (Source: Pain Physician)
Source: Pain Physician - November 29, 2023 Category: Anesthesiology Authors: Alexandra Boyd Ajith Malige Orr Limpisvasti Source Type: research
The Association Between Endometriosis Treatments and Depression and/or Anxiety in a Population-Based Pathologically Confirmed Cohort of People with Endometriosis
CONCLUSION: Endometriosis patients with co-occurring depression and/or anxiety used more health services for pain, including prescription-level analgesics, and were more likely to have an endometriosis reoperation. We recommend that future study should aim to better understand the direction of this association between depression and/or anxiety and increased health services use.PMID:38023374 | PMC:PMC10664573 | DOI:10.1089/whr.2023.0068 (Source: Pain Physician)
Source: Pain Physician - November 29, 2023 Category: Anesthesiology Authors: Emma Goodwin Helena Abreu do Valle Amanda Nitschke Joseph Puyat Paul J Yong Gillian E Hanley Source Type: research
