Long non-coding RNA LOXL1-AS1: a potential biomarker and therapeutic target in human malignant tumors
This article reviews the current understanding of the biological function and clinical significance of LOXL1-AS1 in human cancers. These findings suggest that LOXL1-AS1 may be both a reliable biomarker and a potential therapeutic target for cancers.PMID:38693424 | DOI:10.1007/s10238-024-01355-7 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Xiao-Ping Fu Chun-Yan Ji Wen-Qian Tang Ting-Ting Yu Lei Luo Source Type: research
Long non-coding RNA LOXL1-AS1: a potential biomarker and therapeutic target in human malignant tumors
This article reviews the current understanding of the biological function and clinical significance of LOXL1-AS1 in human cancers. These findings suggest that LOXL1-AS1 may be both a reliable biomarker and a potential therapeutic target for cancers.PMID:38693424 | DOI:10.1007/s10238-024-01355-7 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Xiao-Ping Fu Chun-Yan Ji Wen-Qian Tang Ting-Ting Yu Lei Luo Source Type: research
Mismatch repair deficiency and abnormal p53 expression has significant predictive value for progesterone resistance and endometrial tumorigenesis in patients with endometrial atypical hyperplasia receiving fertility-preserving treatment
CONCLUSIONS: EAH patients with MMR-d and p53abn have a significantly higher risk of disease relapse and progression. Thus, MMR-d and p53abn may be used as predictive biomarkers of progestin resistance and endometrial tumorigenesis in EAH.PMID:38691985 | DOI:10.1016/j.ygyno.2024.04.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 1, 2024 Category: Cancer & Oncology Authors: Hongfa Peng Jingjing Jiang Limeng Li Zengfang Hao Hongguang Lian Hui Du Wei Wang Source Type: research
Extended-duration antibiotics are not associated with a reduction in surgical site infection in patients with ovarian cancer undergoing cytoreductive surgery with large bowel resection
CONCLUSION(S): In this retrospective study of patients with advanced ovarian cancer undergoing CRS with LBR, extended post-operative ABX was not associated with reduced SSI, and prolonged administration of antibiotics should be avoided unless clinically indicated.PMID:38691986 | DOI:10.1016/j.ygyno.2024.04.003 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 1, 2024 Category: Cancer & Oncology Authors: Julia Chalif Laura M Chambers Meng Yao Michelle Kuznicki Robert DeBernardo Peter G Rose Chad M Michener Roberto Vargas Source Type: research
"Having cancer is very expensive": A qualitative study of patients with ovarian cancer and PARP inhibitor treatment
CONCLUSIONS: Patients identified cost, restrictive pharmacy benefits, and initial side effects as barriers to PARP-I usage. Having insurance and a supportive care team were identified as facilitators. Enhancing communication about PARP-I cost and side effects could improve patient experience and receipt of evidence-based maintenance therapy in ovarian cancer.PMID:38691987 | DOI:10.1016/j.ygyno.2024.04.018 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 1, 2024 Category: Cancer & Oncology Authors: Anna Jo Bodurtha Smith Caroline O'Brien Ashley Haggerty Emily M Ko Katharine A Rendle Source Type: research
Evaluating the development of endometriosis and adenomyosis lesions over time: An ultrasound study of symptomatic women
ConclusionsOur findings suggest that in symptomatic women, endometriosis and adenomyosis lesions visible at ultrasound may develop over time. However, majority of women remain having normal ultrasound examinations despite symptoms. Exacerbation of dysmenorrhea or chronic pelvic pain during follow-up was not associated with the development of endometriosis or adenomyosis lesions visible at ultrasound, suggesting that even women with less severe symptoms might benefit from a follow-up ultrasound when indicated. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - May 1, 2024 Category: OBGYN Authors: Sofie Orlov,
Povilas Sladkevicius,
Ligita Jokubkiene Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Fat-free mass index is a feasible predictor of insulin resistance in women with polycystic ovary syndrome: Evidence from a cross-sectional study
ConclusionThese results indicated that FFMI and FMI could significantly increase the risk of IR, both of which could be feasible predictors of IR in PCOS women. (Source: Endocrine)
Source: Endocrine - May 1, 2024 Category: Endocrinology Source Type: research
Response to the Letter to the Editor by Jorge Violante-Cumpa; Marina Norde & amp; Geloneze Geloneze “Fat-free mass index is a feasible predictor of insulin resistance in women with polycystic ovary syndrome: evidence from a cross-sectional study”
(Source: Endocrine)
Source: Endocrine - May 1, 2024 Category: Endocrinology Source Type: research
6275602 Anesthetic management of a pregnant patient with congenital long QT syndrome type 2 undergoing ovarian dermoid cyst excision: A Case Report
(Source: International Journal of Obstetric Anesthesia)
Source: International Journal of Obstetric Anesthesia - May 1, 2024 Category: Anesthesiology Authors: Ali Alwadani, Abdelrady Ibrahim, Fatemah Qasem Source Type: research
Knockdown of CENPM activates cGAS-STING pathway to inhibit ovarian cancer by promoting pyroptosis
We aimed to screen novel gene signatures for ovarian cancer (OC) and explore the role of biomarkers in OC via regulating pyroptosis using bioinformatics analysis. (Source: BMC Cancer)
Source: BMC Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Wei Xie, Leiying Zhang, Junjing Shen, Fengdi Lai, Wenling Han and Xiaoyan Liu Tags: Research Source Type: research
Ovarian cancer risk among older patients with stable adnexal masses
Few studies have evaluated the risk of cancer among older patients with stable adnexal masses in community-based settings to inform the duration of observation time needed. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - May 1, 2024 Category: OBGYN Authors: Elizabeth J. SUH-BURGMANN, Yun-Yi HUNG, Julie A. SCHMITTDIEL Tags: Original Research: Gynecology Source Type: research
Associations between Hysterectomy and Metabolic Syndrome: The Multi-Ethnic Study of Atherosclerosis
Metabolic syndrome is linked to an increased risk of incident cardiovascular disease (CVD) and all-cause mortality. Notable associations exist between hysterectomy with bilateral salpingo-oophorectomy and metabolic syndrome. However, there is emerging evidence that even with ovarian conservation, hysterectomy may be independently associated with long-term CVD risk. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - May 1, 2024 Category: OBGYN Authors: Eric K. BRONI, Justin B. ECHOUFFO TCHEUGUI, Anna PALATNIK, Ernest M. GRAHAM, Ruth-Alma TURKSON-OCRAN, Yvonne COMMODORE-MENDAH, Chiadi E. NDUMELE, Erin D. MICHOS Tags: Original Research: Gynecology Source Type: research
Dysgerminoma with Syncytiotrophoblastic Giant Cells Associated with a Concurrent Ectopic Pregnancy
AbstractBackgroundDysgerminomas constitute around 1 –2% of all germ cell tumours. It is very very rare to have dysgerminoma with concurrent pregnancy with an incidence of 0.2–1 per 100,000 pregnancies. It is extremely difficult to conceive with no assisted reproductive interventions and carry it till completion with no complications in a concurre nt dysgerminoma. Dysgerminoma has a characteristic specific histomorphology and is easy to diagnose. However, occasionally, syncytiotrophoblastic differentiation can be seen in dysgerminoma although it is a rare histopathological finding. Also, the raised serum B-HCG levels du...
Source: Indian Journal of Surgical Oncology - May 1, 2024 Category: Cancer & Oncology Source Type: research
Response to the Letter to the Editor by Jorge Violante-Cumpa; Marina Norde & amp; Geloneze Geloneze “Fat-free mass index is a feasible predictor of insulin resistance in women with polycystic ovary syndrome: evidence from a cross-sectional study”
(Source: Endocrine)
Source: Endocrine - May 1, 2024 Category: Endocrinology Source Type: research
Alterations of cardiometabolic risk profile in polycystic ovary syndrome: 13 years follow-up in an unselected population
ConclusionsAging women with PCOS in the population have higher androgen levels and similar cardiometabolic risk profile compared to age- and BMI-matched healthy women. Epicardial fat thickness, a marker of cardiometabolic risk, appear to be associated with hyperandrogenism. Further research is needed on larger community-based cohorts where older patients are assessed with a longer follow-up. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 1, 2024 Category: Endocrinology Source Type: research
