Dexamethasone measurement during low-dose suppression test for suspected hypercortisolism: threshold development with and validation
ConclusionsWe developed and validated the routine dexamethasone measurement during 1-mg DST: it is independent from patient ’s clinical presentation, and it should be used to increase the specificity of serum cortisol levels. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 14, 2020 Category: Endocrinology Source Type: research

Our Lady of Carmel and Saints of Pietro Novelli (1603 –1647)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 14, 2020 Category: Endocrinology Source Type: research

Under-carboxylated osteocalcin regulates glucose and lipid metabolism during pregnancy and lactation in rats
ConclusionTaken together, we found that UcOC plays an important role in energy homeostasis via regulation of glucose and lipid metabolism during pregnancy and lactation. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 13, 2020 Category: Endocrinology Source Type: research

5 α-Reductase-2 deficiency: is gender assignment recommended in infancy? Two case-reports and review of the literature
ConclusionsThe reported cases suggest the possibility to consider a new approach for gender assignment in these individuals, involving them directly in the decision-making process and allowing them to explore their gender identity, also with the help of GnRH analogues to delay pubertal modifications. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 8, 2020 Category: Endocrinology Source Type: research

Schoolchildren thyroid volume in North Macedonia: data from a national survey in an iodine-sufficient country
AbstractPurposeNorth Macedonia is historically iodine deficient, but due to the longstanding and effective preventive measures, it has been considered iodine replete since 2003. The aim of the recent national survey was to re-evaluate iodine status and to measure thyroid volume (TVol) by ultrasound in schoolchildren as a representative of the general population.MethodsA stratified probability proportionate to size cluster sampling was used to obtain a representative national sample of school children aged 7 –10 years between the 28th of March and 4th of October 2016. Thyroid volume (TVol) was measured using ultr...
Source: Journal of Endocrinological Investigation - February 4, 2020 Category: Endocrinology Source Type: research

R230C but not − 565C/T variant of the ABCA1 gene is associated with type 2 diabetes in Mexicans through an effect on lowering HDL-cholesterol levels
AbstractPurposeType 2 diabetes (T2D) and low serum concentration of high-density lipoprotein cholesterol (HDL-c) are common coexisting metabolic disorders.ABCA1 variants have been shown to be associated to these conditions. We sought to test the combined effect of twoABCA1 gene common variants, rs2422493 ( − 565C >  T) and rs9282541 (R230C) on HDL-c levels and T2D risk.MethodsPath analysis was conducted in 3,303 Mexican-mestizos to assess the specific contributions of rs2422493 and rs9282541ABCA1 variants, insulin resistance, waist-to-height ratio (WHtR), and age on HDL-c levels and T2D risk. ...
Source: Journal of Endocrinological Investigation - February 3, 2020 Category: Endocrinology Source Type: research

Hormonal profile of menopausal women receiving androgen replacement therapy: a meta-analysis
ConclusionsWhatever androgen formulation we choose in postmenopausal women, the end result is a rise in testosterone serum levels. However, DHEA regimen is also associated with an increased estrogenic availability. This might be crucial when choosing the best possible treatment for each patient individually taking into consideration if potential benefits outweigh the risks. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 3, 2020 Category: Endocrinology Source Type: research

Impact of using different biomarkers of liver fibrosis on hepatologic referral of individuals with severe obesity and NAFLD
ConclusionStrict application of the guidelines in individuals with severe obesity would probably lead to over-referral, although a great variability exists among the different scores. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 1, 2020 Category: Endocrinology Source Type: research

Gender disparity in editorial boards of scientific journals in endocrinology
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 28, 2020 Category: Endocrinology Source Type: research

Transoral thyroid surgery vestibular approach: does size matter anymore?
ConclusionsTransoral thyroid and parathyroid surgery via the vestibular approach is both feasible and safe in Western Europe. The combination of the TOETVA with the retroauricular endoscopic cephalic access thyroid surgery (EndoCATS) facelift approach, called TOVARA, is a promising opportunity to allow for thyroid surgery without a visible scar in specimen with volume of more than 40  ml also. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 28, 2020 Category: Endocrinology Source Type: research

The haemostatic system in acromegaly: a single-centre case –control study
AbstractPurposeAlthough the mortality from acromegaly is due in most cases to an increased cardiovascular risk, no study has globally evaluated the haemostatic balance in acromegaly to ascertain the presence of hypercoagulability. We endeavoured to assess the overall coagulation profile in patients with acromegaly using both traditional and global coagulation assays.MethodsConsecutive outpatients with a diagnosis of acromegaly were enrolled and matched with healthy subjects. Whole blood thromboelastometry and impedance aggregometry, procoagulant, anticoagulant and fibrinolytic factors, as well as thrombin-generation assay ...
Source: Journal of Endocrinological Investigation - January 28, 2020 Category: Endocrinology Source Type: research

Obituary: Renato Pasquali (1946 –2019)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 28, 2020 Category: Endocrinology Source Type: research

Metabolic syndrome is the key determinant of impaired vaginal lubrication in women with chronic spinal cord injury
AbstractPurposeSpinal cord injury (SCI) affects sexual health of both male and female, but little attention has been given to sexuality of SCI women. Similar to penile erection, vaginal lubrication represents a neurovascular event and then both denervation and vascular damage might contribute to its impairment. Nevertheless, the relative weight of lesion location/degree and vascular risk factors in determining hypolubrication in women with SCI has not yet been investigated. The aim of this study was to recognize among putative determinants of poor sexual arousal in women with SCI, neurogenic and vascular/metabolic independ...
Source: Journal of Endocrinological Investigation - January 25, 2020 Category: Endocrinology Source Type: research

The triglycerides and glucose index is associated with cardiovascular risk factors in metabolically obese normal-weight subjects
ConclusionResults of this study support that the TyG index may be a useful indicator to detect MONW phenotype and associated cardiovascular risk factors. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 22, 2020 Category: Endocrinology Source Type: research

Comprehensive transcriptomic analysis of papillary thyroid cancer: potential biomarkers associated with tumor progression
ConclusionStage I PTC patients showed large amount of expressional heterogeneity. Therefore, risk stratification based on the expressional alterations of candidate biomarkers could be an important step toward personalized management of these patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 21, 2020 Category: Endocrinology Source Type: research

ICH3, a selective alpha7 nicotinic acetylcholine receptor agonist, modulates adipocyte inflammation associated with obesity
This study aims to test the ability of a selective synthetic α7nAChR agonist, the spirocyclic Δ2-isoxazoline derivative (R)-( −)-ICH3 (ICH3), to counteract acute inflammation and obesity-associated modifications in WAT.MethodsWe employed the LPS-septic shock murine model, human primary adipocytes and diet-induced obese (DIO) mice. Inflammatory factor expression was assessed by ELISA and quantitative real-time PCR. Flow cytometry was employed to define WAT inflammatory infiltrate. Insulin signaling was monitored by quantification of AKT phosphorylation.ResultsIn the septic shock model, ICH3 revealed antipy...
Source: Journal of Endocrinological Investigation - January 21, 2020 Category: Endocrinology Source Type: research

Effects of renin –angiotensin system blockers on renal and cardiovascular outcomes in patients with diabetic nephropathy: a meta-analysis of randomized controlled trials
ConclusionsPatients with DN receiving ACEI had significantly reduced the risk of total MACEs, and ARB could reduce the incidence of ESRD and the doubling of serum creatinine levels. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 14, 2020 Category: Endocrinology Source Type: research

MicroRNAs expression in pituitary tumors: differences related to functional status, pathological features, and clinical behavior
ConclusionsIn this study, we found a significant down-regulation of 17 miRNAs in PAs vs normal pituitary, with differential expression profile related to functional status and tumor aggressiveness. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 14, 2020 Category: Endocrinology Source Type: research

Two novel truncating variants of the AAAS gene causative of the triple A syndrome
ConclusionsOur findings establish a pathogenic role for both new variants. Moreover, our data highlight the essential role of the C-terminal domain of the protein for its correct targeting and function and underline the importance of sequencing splice sites surrounding the intron –exon junctions to ensure accurate molecular diagnosis and correct genetic counseling in AAAS patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 14, 2020 Category: Endocrinology Source Type: research

Clinical features may help to identify children and adolescents with greatest risk for thyroid nodules
ConclusionTN were less common in those with AIT than reported in previous studies, suggesting that clinical features might fail to identify the majority of TN in patients with AIT. However, patients with asymmetric thyroid and a family history of TN or DTC have greatest risk for TN. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 11, 2020 Category: Endocrinology Source Type: research

Tear inflammatory cytokines and ocular surface changes in patients with active thyroid eye disease treated with high-dose intravenous glucocorticoids
ConclusionsHigh-dose glucocorticoids treatment improved ocular surface symptom, increased the tear film stability, and decreased tear inflammatory cytokines in active TED. The reduction of the inflammatory cytokines is consistent with the improvement of clinical parameters. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 11, 2020 Category: Endocrinology Source Type: research

Cushing syndrome at the court of the infant of Spain in the eighteenth century?
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 11, 2020 Category: Endocrinology Source Type: research

Perimenopause, body fat, metabolism and menopausal symptoms in relation to serum markers of adiposity, inflammation and digestive metabolism
ConclusionPerimenopausal women with EBMI and the MetS showed an altered metabolic profile, but no differences in menopausal symptoms which also did not correlate with changes in studied biomarkers. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 10, 2020 Category: Endocrinology Source Type: research

Association between vitamin D deficiency and common variants of Vitamin D binding protein gene among Mexican Mestizo and indigenous postmenopausal women
AbstractPurposeVitamin D deficiency (VDD) and polymorphisms in the group-specific component (GC) gene are known to be associated in different populations. However, the effects of such genetic variants may vary across different populations. Thus, the objective of this study was to estimate the association between Vitamin D-Binding Protein (VDBP) haplotypes and VDD in mestizo postmenopausal women and Mexican Amerindian ethnic groups.MethodsThis was a cross-sectional study of 726 postmenopausal Mexican women from the Health Workers Cohort Study (HWCS) and 166 postmenopausal women from the Metabolic Analysis in an Indigenous S...
Source: Journal of Endocrinological Investigation - January 6, 2020 Category: Endocrinology Source Type: research

Will the shepherd be able to play the alpine horn with that huge goiter (XVI century)?
ConclusionThis is an appropriate example of the iconography of “real goiter,” since in this case the sculptor had the aim of showing person with goiter. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 6, 2020 Category: Endocrinology Source Type: research

Long-term ultrasound follow-up of intrathyroidal ectopic thymus in children
ConclusionThe reproducibility of unique ultrasound features of IETs allows for safe long-term follow-up of these benign lesions in the majority of pediatric patients: not only monitoring the regression of IET but also screening towards the rare occurrence of a tumor arising from the IET. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 4, 2020 Category: Endocrinology Source Type: research

Does autoimmune hypothyroidism increase the risk of neurovascular complications in type 1 diabetes?
ConclusionsAHT coexisting with T1DM was associated with a higher incidence of neurovascular complications. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 3, 2020 Category: Endocrinology Source Type: research

Alternate-day calcium dosing may be an effective treatment option for chronic hypoparathyroidism
ConclusionPatients with uncontrolled chronic hypoparathyroidism could be controlled more effectively with alternate-day dosing regimen. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 3, 2020 Category: Endocrinology Source Type: research

Is Somatostatin Receptor and Dopamine Receptor profiling useful in the management of silent somatotroph tumors?
AbstractSilent somatotroph tumors (sSTs) are pituitary neuroendocrine tumors (PitNETs) which do not give rise to the clinical syndrome of acromegaly. Differently to their functioning counterparts, the adjuvant medical treatment with somatostatin analogues (SSAs) or dopamine receptors agonists (DAs) has been scarcely addressed in these tumors. As preliminary results of an ongoing research on silencing mechanisms involved in the pathogenesis of sSTs, we have characterized by qRT-PCR the expression of SSTRs and DRDs in a large series of 18 silent and 68 functioning STs. Although the expression ofSSTR2 andSSTR5 was lower in sS...
Source: Journal of Endocrinological Investigation - January 2, 2020 Category: Endocrinology Source Type: research

Thyroid hormones T3 and T4 regulate human luteinized granulosa cells, counteracting apoptosis and promoting cell survival
ConclusionFrom the present study, THs emerge as potent anti-apoptotic agents in hGL cells. This effect is achieved by inhibiting the apoptosis signalling pathway of BAX and caspase-3, while maintaining active the PI3K/AKT pathway. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 1, 2020 Category: Endocrinology Source Type: research

Hypercalciuria: its value as a predictive risk factor for nephrolithiasis in asymptomatic primary hyperparathyroidism?
ConclusionsHypercalciuria is a predictor of nephrolithiasis, but its PPV is low. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 23, 2019 Category: Endocrinology Source Type: research

Association of thyroid cancer risk with plasma 25-hydroxyvitamin D and vitamin D binding protein: a case –control study in China
ConclusionsThis study suggested that 25(OH)D and DBP had protective effects against TC. But the negative association between TC and DBP might be modified by 25(OH)D and physical activity. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 20, 2019 Category: Endocrinology Source Type: research

FGF23-related hypophosphatemia in patients with low bone mineral density and fragility fractures: challenges in diagnosis and management
ConclusionMild, apparently unexplained HP is observed in 0.82% of patients with low bone density or fragility fractures. In asymptomatic patients with isolated mild hypophosphatemia, the probability of finding an underlying tumor disease is very low, and utility of extensive and expensive diagnostic workup should be carefully considered in this setting. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 20, 2019 Category: Endocrinology Source Type: research

Molecular markers for the classification of cytologically indeterminate thyroid nodules
ConclusionsIn the present review, the most recent available versions of commercial molecular tests and of custom, non-commercial panels are described. Their characteristics and accuracy in the differential diagnosis of indeterminate nodules, namely Bethesda classes III (Atypical follicular lesion of undetermined significance, AUS/FLUS) and IV (Suspicious for follicular neoplasm, FN/SFN) are fully analyzed and discussed. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 18, 2019 Category: Endocrinology Source Type: research

Development of a novel score to predict probability of growth without growth hormone after resection of paediatric craniopharyngiomas: relative to tumour growth pattern
ConclusionsBased on tumour growth patterns and PC patients ’ clinical characteristics, individualized surgical strategies were promising to achieve long-term effective management of PC patients. The ICS is valuable for the evaluation of probability of developing postoperative GWGH.Clinical trial registrationClinicalTrials.gov ID: NCT00949156. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 18, 2019 Category: Endocrinology Source Type: research

Non-invasive and real-time proliferative activity estimation based on a quantitative radiomics approach for patients with acromegaly: a multicenter study
ConclusionsThe radiomics signature developed in this study could aid neurosurgeons in predicting the Ki-67 index of patients with acromegaly and could contribute to non-invasive measurement of proliferative activity, affecting individual treatment strategies. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 17, 2019 Category: Endocrinology Source Type: research

Micronutrients in support to the one carbon cycle for the modulation of blood fasting homocysteine in PCOS women
ConclusionsIn PCOS ladies, blood homocysteine is increased and inversely correlated with the SHBGs. Physiologic amounts of activated micronutrients in support to the carbon cycle achieve a reduction virtually in all exposed patients. Whether this is of clinical benefit remains to be established. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 16, 2019 Category: Endocrinology Source Type: research

Kisspeptin and neurokinin B analogs use in gynecological endocrinology: where do we stand?
ConclusionsThere is a wide spectrum of therapeutic uses of Kiss-1 and NKB agonists, including the management of infertility, treatment for PCOS, functional hypothalamic amenorrhea or postmenopausal vasomotor symptoms, as well as contraceptive issues. Nevertheless, further research is needed before kisspeptin and NKB analogs are fully incorporated in clinical practice. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 14, 2019 Category: Endocrinology Source Type: research

Systemic safety analysis of mycophenolate in Graves ’ orbitopathy
ConclusionThe risk –benefit ratio of low-dose mycophenolate treatment in active moderate-to-severe GO is highly favorable given its reassuring safety profile with low rate of mild-to-moderate SE and promising efficacy. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 13, 2019 Category: Endocrinology Source Type: research

XRCC1 Arg194Trp polymorphism and thyroid cancer
ConclusionThis study suggested that the C allele of XRCC1 had an 18% significantly decreased risk of TC in Chinese, and there were no significant associations among Caucasians under all genetic models. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 9, 2019 Category: Endocrinology Source Type: research

Primary sellar melanocytoma: pathological, clinical and treatment review
ConclusionsTranssphenoidal surgery is the first-choice treatment. In case of tumor ’s recurrence or regrowth, the role of radiation therapy and chemotherapy is not entirely clear. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 3, 2019 Category: Endocrinology Source Type: research

Hormonal and metabolic gender differences in a cohort of myotonic dystrophy type 1 subjects: a retrospective, case –control study
AbstractPurposeMyotonic dystrophy type 1 (DM1) is a genetic disorder caused by CTG expansion in the DMPK gene. The aim was to investigate the endocrine and metabolic aspects of DM1.Patients and methodsRetrospective, case –control study. We compared pituitary, thyroid, adrenal, gonadal and liver function and glycolipid metabolism of 63 DM1 patients against 100 control subjects. Given age-related differences, 2 further subgroups were created to investigate the pituitary–gonadal axis: 
Source: Journal of Endocrinological Investigation - November 30, 2019 Category: Endocrinology Source Type: research

DR10601, a novel recombinant long-acting dual glucagon-like peptide-1 and glucagon receptor agonist for the treatment of obesity and type 2 diabetes mellitus
ConclusionsRepeated administration of DR1060 provides potent and sustained glycemic control and body weight loss effect in high-fat DIO mice. DR10601 is a promising long-acting agent deserving further investigation for the treatment of type 2 diabetes and obesity. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 30, 2019 Category: Endocrinology Source Type: research

The multinodular goiter of the virtuous Roman matron Lucretia by Artemisia Gentileschi
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 30, 2019 Category: Endocrinology Source Type: research

Treatment of Graves ’ hyperthyroidism with thionamides: a position paper on indications and safety in pregnancy
ConclusionsThis consensus by experts from Italian Endocrine and Gynecologic Scientific Societies has edited recommendations derived form the available data and published guidelines of International Scientific Societies. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 29, 2019 Category: Endocrinology Source Type: research

Monitoring exercise intensity in diabetes: applicability of “heart rate-index” to estimate oxygen consumption during aerobic and resistance training
AbstractPurposeAccurate quantification and monitoring of exercise “dose”, described by oxygen consumption (VO2), is necessary for exercise prescription and individualization. However, due to the complexity and elevated cost of direct, gold-standard methods, this is rarely done outside research laboratories. Heart rate-index (HRindex) is a new simple method to estimate VO2 in healthy and clinical populations. We tested the performance of HRindex to estimate VO2 in diabetic patients during aerobic (AT) and isotonic training (IT).MethodsData from 12 males (age: 64  ± 5 years; BMI: 26&thin...
Source: Journal of Endocrinological Investigation - November 28, 2019 Category: Endocrinology Source Type: research

Perfluoro-octanoic acid impairs sperm motility through the alteration of plasma membrane
ConclusionPFOA alters human sperm motility through plasma-membrane disruption, an effect recovered by incubation with β-CD. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 27, 2019 Category: Endocrinology Source Type: research

Towards the tailoring of glucocorticoid replacement in adrenal insufficiency: the Italian Society of Endocrinology Expert Opinion
ConclusionsIn the Panel ’s opinion, achieving the optimal GC timing and dosing is needed to improve the outcome of AI. No-single formulation offers the best option for every patients. Recent data suggest that more emphasis should be given to the timing of intake. Tailoring of GS should be attempted in all patients—by e xperts—on a case-by-case basis. The Panel identified specific subgroups of AI patients that could be help by this process. Long-term studies are needed to confirm the short-term benefits associated with the modified-release GCs. The impact of GC tailoring has yet to be proven in terms ...
Source: Journal of Endocrinological Investigation - November 26, 2019 Category: Endocrinology Source Type: research

Determinants of outcome of transsphenoidal surgery for Cushing disease in a single-centre series
ConclusionCushing disease is characterized by a broad spectrum of neuroradiological presentation. Despite the availability of a DST make the TSS a safe and effective first-line treatment among all these patients, a precise pre-treatment evaluation is needed in order to define the aim of neurosurgery and to schedule the management of recurrent disease. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 26, 2019 Category: Endocrinology Source Type: research

Total tumor diameter: the neglected value in papillary thyroid microcarcinoma
ConclusionFor multifocal micro-PTC, TTD can better assess the aggressiveness of the tumor. Multifocal micro-PTC with TTD>  1 cm was more aggressive than unifocal micro-PTC or multifocal micro-PTC with TTD ≤ 1 cm. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 20, 2019 Category: Endocrinology Source Type: research