Prognostic evaluation models for primary thyroid lymphoma, based on the SEER database and an external validation cohort
This study aimed to assess the epidemiologic characteristics, survival, and prognostic factors of patients with PTL.MethodsWe analyzed 2215 PTL patients from the Surveillance, Epidemiology, and End Results database medical records, between 1983 and 2015, as the training cohort. We enrolled 105 patients from the Cancer Hospital, Chinese Academy of Medical Sciences, for the external validation cohort. The nomograms for predicting the 1-, 5-, and 10-year overall survival (OS) and lymphoma-specific survival (LSS) were constructed.ResultsPTL incidence steadily increased from 1977 to 1994, with an annual percentage change of 3.2...
Source: Journal of Endocrinological Investigation - December 4, 2021 Category: Endocrinology Source Type: research

Circ_0059354 aggravates the progression of papillary thyroid carcinoma by elevating ARFGEF1 through sponging miR-766-3p
ConclusionCirc_0059354 served as an oncogene in PTC progression through regulating miR-766-3p/ARFGEF1 axis. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 2, 2021 Category: Endocrinology Source Type: research

Long-term remission of acromegaly after somatostatin analogues withdrawal: a single-centre experience
ConclusionA successful withdrawal of SAs is possible in a subset of well-controlled acromegalic patients and it challenges the concept that medical therapy is a lifelong requirement. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 8, 2021 Category: Endocrinology Source Type: research

Effects of testosterone treatment on clitoral haemodynamics in women with sexual dysfunction
AbstractPurposeTo explore the effects of 6-month systemic testosterone (T) administration on clitoral color Doppler ultrasound (CDU) parameters in women with female sexual dysfunction (FSD).Methods81 women with FSD were retrospectively recruited. Data on CDU parameters at baseline and after 6 months with four different treatments were available and thus further longitudinally analyzed: local non-hormonal moisturizers (NH group),n = 37; transdermal 2% T gel 300 mcg/day (T group),n = 23; local estrogens (E group),n = 12; combined therapy (T + E group),n = ...
Source: Journal of Endocrinological Investigation - November 8, 2021 Category: Endocrinology Source Type: research

Thyroid and heart, a clinically relevant relationship
ConclusionsThe review will summarize, in the first part, the physiopathological link between thyroid hormone imbalances and the cardiovascular system. In the second part the review will outline the evidence coming from meta-analyses regarding the cardiovascular risk related with both overt and subclinical thyroid dysfunctions. Particular attention will be put towards studies showing data stratified for patient ’s age, TSH levels and pre-existing cardiovascular disease. Finally, an overview regarding the effects of specific therapy for subclinical thyroid diseases in terms of amelioration of cardiovascular outcomes wi...
Source: Journal of Endocrinological Investigation - November 8, 2021 Category: Endocrinology Source Type: research

Echocardiographic findings in acromegaly: prevalence of concentric left ventricular remodeling in a large single-center cohort
ConclusionEarly diagnosis of acromegaly and disease control should be attempted to prevent LVH/LV dysfunction and development of valvular heart disease. Concentric LV remodeling develops prior to obvious LV hypertrophy in almost a third of patients with acromegaly, which is a novel finding. Similar to other epidemiological studies, we found a high prevalence of LVH/LV dysfunction. Although possible, reversal of systolic and diastolic dysfunction is sporadic after treatment of acromegaly. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 8, 2021 Category: Endocrinology Source Type: research

Novel AVPR2 mutations and clinical characteristics in 28 Chinese families with congenital nephrogenic diabetes insipidus
ConclusionIn the first and largest case series of NDI caused byAVPR2 mutations in Chinese population, we established genetic profile and characterized clinical data, reporting six novel mutations. Further, we found genotype was associated with phenotype. This knowledge broadens genotype and phenotype spectrum of rare congenital NDI caused byAVPR2 mutations, and provides basis for studying molecular biology of AVPR2. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 8, 2021 Category: Endocrinology Source Type: research

Extracellular vesicles derived from bone marrow mesenchymal stem cells alleviate neuroinflammation after diabetic intracerebral hemorrhage via the miR-183-5p/PDCD4/NLRP3 pathway
ConclusionBMSC-EVs carried miR-183-5p into db/db-ICH rat brain tissues and repressed the NLRP3 pathway by targeting PDCD4, thus alleviating neuroinflammation after diabetic ICH. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 8, 2021 Category: Endocrinology Source Type: research

Combination of ultrasound and molecular testing in malignancy risk estimate of Bethesda category IV thyroid nodules: results from a single-institution prospective study
ConclusionUS risk stratification and FNAC molecular testing may synergistically contribute to improve malignancy risk estimate of Bethesda category IV thyroid nodules. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 8, 2021 Category: Endocrinology Source Type: research

First-line surgery in prolactinomas: lessons from a long-term follow-up study in a tertiary referral center
ConclusionsFirst-line surgery in patients with microprolactinomas or macroprolactinomas Knosp grade 0 resulted in a good chance of non-dependency on DA therapy. However, in patients with prolactinomas Knosp grade 1, first-line surgery cannot be recommended, as adjuvant DA therapy after surgery is required in the majority of them over the long term. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 8, 2021 Category: Endocrinology Source Type: research

Protocol for presurgical and anesthetic management of pheochromocytomas and sympathetic paragangliomas: a multidisciplinary approach
ConclusionsAn optimal presurgical evaluation of pheochromocytomas/ sympathetic PGL requires a multidisciplinary approach, including a complete hormonal, radiological, cardiac, genetic, and functioning evaluation in most cases. A proper preoperative evaluation in combination with strict blood pressure and heart rate control, and blood volume status optimization, will significantly reduce the risk of intraoperative and perioperative complications. In those patients who unfortunately develop intraoperative complications, the role of the anesthesiologist is essential since the selection of the appropriate management has a dire...
Source: Journal of Endocrinological Investigation - November 8, 2021 Category: Endocrinology Source Type: research

Retrospective analysis of vitamin D status on ınflammatory markers and course of the disease in patients with COVID-19 infection
ConclusionCases with lower vitamin D status had increased inflammatory markers and worse clinical outcomes than patients with higher vitamin D status. This study suggests that vitamin D status can be used as a prognostic factor in COVID-19 patients, and vitamin D supplementation can be recommended to improve the clinical outcomes in COVID-19 infection. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 8, 2021 Category: Endocrinology Source Type: research

Molecular diagnosis of SARS-CoV-2 in seminal fluid
ConclusionThese preliminary data show that RT-PCR for SARS-CoV-2 RNA testing appears to be a feasible method for the molecular diagnosis of SARS-CoV-2 in seminal fluid, supported by results of the control panel. The ability to detect SARS-CoV-2 in semen is extremely important for reproductive medicine, especially in assisted reproductive technology and sperm cryopreservation. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 8, 2021 Category: Endocrinology Source Type: research

Haplotypes of the genes (GCK and G6PC2) underlying the glucose/glucose-6-phosphate cycle are associated with pancreatic beta cell glucose sensitivity in patients with newly diagnosed type 2 diabetes from the VNDS study (VNDS 11)
In this study, we evaluated the association between the genetic variability ofG6PC2 andGCK genes and T2D-related quantitative traits.MethodsIn 794 drug-na ïve, GADA-negative, newly diagnosed T2D patients (VNDS; NTC01526720) we performed: genotyping of 6 independent tag-SNPs withinGCK gene and 5 tag-SNPs withinG6PC2 gene; euglycaemic insulin clamp to assess insulin sensitivity; OGTT to estimate beta-cell function (derivative and proportional control; DC, PC) by mathematical modeling. Genetic association analysis has been conducted using Plink software.ResultsTwo SNPs withinGCK gene (rs882019 and rs1303722) were associa...
Source: Journal of Endocrinological Investigation - November 8, 2021 Category: Endocrinology Source Type: research

Free triiodothyronine (T3) is negatively associated with fasting ghrelin serum levels in a population sample of euthyroid subjects
AbstractPurposeGhrelin is an orexigenic peptide hormone secreted in times of stress and hunger. It is deeply involved in the regulation of metabolism and energy homeostasis, promoting energy intake and inhibiting energy expenditure on a metabolic level. In this regard, it has in many ways antagonistic effect on the thyroid hormones, which increase metabolism and thus energy expenditure. While there is reasonable evidence of a negative association between ghrelin and hormones of the hypothalamic-pituitary-thyroid (HPT-) axis from studies in patients with thyroid dysfunction and small intervention studies, large-scale studie...
Source: Journal of Endocrinological Investigation - November 8, 2021 Category: Endocrinology Source Type: research

Central diabetes insipidus (Infundibuloneuro hypophysitis): A late complication of COVID-19 infection
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 8, 2021 Category: Endocrinology Source Type: research

Metabolic syndrome in the era of COVID-19 outbreak: impact of lockdown on cardiometabolic health
AbstractPurposeCOVID-19 pandemics and cardiometabolic health are mutually interconnected. Chronic metabolic diseases are known risk factors for increased mortality after SARS-CoV-2 infection. In turn, COVID pandemics imposed sudden changes in lifestyle and social isolation with consequent potential cardiometabolic sequelae. The present study aimed at investigating the impact of changes in lifestyle and social life on metabolic profile in hyperprolactinemic or osteoporotic patients without pre-existing cardiometabolic diseases at the time of COVID-19.MethodsThe primary study outcome measurement was the prevalence of obesity...
Source: Journal of Endocrinological Investigation - November 8, 2021 Category: Endocrinology Source Type: research

“The Salutation of Beatrice” by Dante Gabriel Rossetti: it was not Beatrice who had goiter but her model
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 8, 2021 Category: Endocrinology Source Type: research

Risks of potential drug –drug interactions in COVID-19 patients treated with corticosteroids: a single-center experience
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 8, 2021 Category: Endocrinology Source Type: research

Correction to: Effects of oral contraceptives on serum concentrations of adipokines and adiposity indices of women with polycystic ovary syndrome: a randomized controlled trial
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 8, 2021 Category: Endocrinology Source Type: research

Cosimo I de Medici and his Merseburg triad of Graves ’ disease
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 8, 2021 Category: Endocrinology Source Type: research

Correction to: Lenvatinib as a salvage therapy for advanced metastatic medullary thyroid cancer
A correction to this paper has been published: https://doi.org/10.1007/s40618-021-01592-7 (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 8, 2021 Category: Endocrinology Source Type: research

Long-term remission of acromegaly after somatostatin analogues withdrawal: a single-centre experience
ConclusionA successful withdrawal of SAs is possible in a subset of well-controlled acromegalic patients and it challenges the concept that medical therapy is a lifelong requirement. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 6, 2021 Category: Endocrinology Source Type: research

Effects of testosterone treatment on clitoral haemodynamics in women with sexual dysfunction
AbstractPurposeTo explore the effects of 6-month systemic testosterone (T) administration on clitoral color Doppler ultrasound (CDU) parameters in women with female sexual dysfunction (FSD).Methods81 women with FSD were retrospectively recruited. Data on CDU parameters at baseline and after 6 months with four different treatments were available and thus further longitudinally analyzed: local non-hormonal moisturizers (NH group),n = 37; transdermal 2% T gel 300 mcg/day (T group),n = 23; local estrogens (E group),n = 12; combined therapy (T + E group),n = ...
Source: Journal of Endocrinological Investigation - November 6, 2021 Category: Endocrinology Source Type: research

Thyroid and heart, a clinically relevant relationship
ConclusionsThe review will summarize, in the first part, the physiopathological link between thyroid hormone imbalances and the cardiovascular system. In the second part the review will outline the evidence coming from meta-analyses regarding the cardiovascular risk related with both overt and subclinical thyroid dysfunctions. Particular attention will be put towards studies showing data stratified for patient ’s age, TSH levels and pre-existing cardiovascular disease. Finally, an overview regarding the effects of specific therapy for subclinical thyroid diseases in terms of amelioration of cardiovascular outcomes wi...
Source: Journal of Endocrinological Investigation - November 6, 2021 Category: Endocrinology Source Type: research

Echocardiographic findings in acromegaly: prevalence of concentric left ventricular remodeling in a large single-center cohort
ConclusionEarly diagnosis of acromegaly and disease control should be attempted to prevent LVH/LV dysfunction and development of valvular heart disease. Concentric LV remodeling develops prior to obvious LV hypertrophy in almost a third of patients with acromegaly, which is a novel finding. Similar to other epidemiological studies, we found a high prevalence of LVH/LV dysfunction. Although possible, reversal of systolic and diastolic dysfunction is sporadic after treatment of acromegaly. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 6, 2021 Category: Endocrinology Source Type: research

Extracellular vesicles derived from bone marrow mesenchymal stem cells alleviate neuroinflammation after diabetic intracerebral hemorrhage via the miR-183-5p/PDCD4/NLRP3 pathway
ConclusionBMSC-EVs carried miR-183-5p into db/db-ICH rat brain tissues and repressed the NLRP3 pathway by targeting PDCD4, thus alleviating neuroinflammation after diabetic ICH. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 6, 2021 Category: Endocrinology Source Type: research

Combination of ultrasound and molecular testing in malignancy risk estimate of Bethesda category IV thyroid nodules: results from a single-institution prospective study
ConclusionUS risk stratification and FNAC molecular testing may synergistically contribute to improve malignancy risk estimate of Bethesda category IV thyroid nodules. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 6, 2021 Category: Endocrinology Source Type: research

Protocol for presurgical and anesthetic management of pheochromocytomas and sympathetic paragangliomas: a multidisciplinary approach
ConclusionsAn optimal presurgical evaluation of pheochromocytomas/ sympathetic PGL requires a multidisciplinary approach, including a complete hormonal, radiological, cardiac, genetic, and functioning evaluation in most cases. A proper preoperative evaluation in combination with strict blood pressure and heart rate control, and blood volume status optimization, will significantly reduce the risk of intraoperative and perioperative complications. In those patients who unfortunately develop intraoperative complications, the role of the anesthesiologist is essential since the selection of the appropriate management has a dire...
Source: Journal of Endocrinological Investigation - November 6, 2021 Category: Endocrinology Source Type: research

Molecular diagnosis of SARS-CoV-2 in seminal fluid
ConclusionThese preliminary data show that RT-PCR for SARS-CoV-2 RNA testing appears to be a feasible method for the molecular diagnosis of SARS-CoV-2 in seminal fluid, supported by results of the control panel. The ability to detect SARS-CoV-2 in semen is extremely important for reproductive medicine, especially in assisted reproductive technology and sperm cryopreservation. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 6, 2021 Category: Endocrinology Source Type: research

Haplotypes of the genes (GCK and G6PC2) underlying the glucose/glucose-6-phosphate cycle are associated with pancreatic beta cell glucose sensitivity in patients with newly diagnosed type 2 diabetes from the VNDS study (VNDS 11)
In this study, we evaluated the association between the genetic variability ofG6PC2 andGCK genes and T2D-related quantitative traits.MethodsIn 794 drug-na ïve, GADA-negative, newly diagnosed T2D patients (VNDS; NTC01526720) we performed: genotyping of 6 independent tag-SNPs withinGCK gene and 5 tag-SNPs withinG6PC2 gene; euglycaemic insulin clamp to assess insulin sensitivity; OGTT to estimate beta-cell function (derivative and proportional control; DC, PC) by mathematical modeling. Genetic association analysis has been conducted using Plink software.ResultsTwo SNPs withinGCK gene (rs882019 and rs1303722) were associa...
Source: Journal of Endocrinological Investigation - November 6, 2021 Category: Endocrinology Source Type: research

Free triiodothyronine (T3) is negatively associated with fasting ghrelin serum levels in a population sample of euthyroid subjects
AbstractPurposeGhrelin is an orexigenic peptide hormone secreted in times of stress and hunger. It is deeply involved in the regulation of metabolism and energy homeostasis, promoting energy intake and inhibiting energy expenditure on a metabolic level. In this regard, it has in many ways antagonistic effect on the thyroid hormones, which increase metabolism and thus energy expenditure. While there is reasonable evidence of a negative association between ghrelin and hormones of the hypothalamic-pituitary-thyroid (HPT-) axis from studies in patients with thyroid dysfunction and small intervention studies, large-scale studie...
Source: Journal of Endocrinological Investigation - November 6, 2021 Category: Endocrinology Source Type: research

Metabolic syndrome in the era of COVID-19 outbreak: impact of lockdown on cardiometabolic health
AbstractPurposeCOVID-19 pandemics and cardiometabolic health are mutually interconnected. Chronic metabolic diseases are known risk factors for increased mortality after SARS-CoV-2 infection. In turn, COVID pandemics imposed sudden changes in lifestyle and social isolation with consequent potential cardiometabolic sequelae. The present study aimed at investigating the impact of changes in lifestyle and social life on metabolic profile in hyperprolactinemic or osteoporotic patients without pre-existing cardiometabolic diseases at the time of COVID-19.MethodsThe primary study outcome measurement was the prevalence of obesity...
Source: Journal of Endocrinological Investigation - November 6, 2021 Category: Endocrinology Source Type: research

Risks of potential drug –drug interactions in COVID-19 patients treated with corticosteroids: a single-center experience
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 6, 2021 Category: Endocrinology Source Type: research

Correction to: Effects of oral contraceptives on serum concentrations of adipokines and adiposity indices of women with polycystic ovary syndrome: a randomized controlled trial
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 6, 2021 Category: Endocrinology Source Type: research

Higher testosterone is associated with increased inflammatory markers in women with SARS-CoV-2 pneumonia: preliminary results from an observational study
ConclusionOpposite to men, in women with SARS-CoV-2 pneumonia, higher TT and cFT are associated with a stronger inflammatory status, probably related to adrenal cortex hyperactivity, (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 3, 2021 Category: Endocrinology Source Type: research

Predictors of reproductive and non-reproductive outcomes of gonadotropin mediated pubertal induction in male patients with congenital hypogonadotropic hypogonadism (CHH)
ConclusionsThis study shows that a strong genetic background and cryptorchidism, as indicators of a complete GnRH deficiency since intrauterine life, are negative predictors of testicular response to gonadotropin stimulation in CHH. Body disproportion is associated with a delay in treatment and duration of growth during the induction, which is apparently inversely related to previous androgenization. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 20, 2021 Category: Endocrinology Source Type: research

Role of thyroid hormone therapy in depressive disorders
ConclusionThe add-on administration of supraphysiologic doses of LT4 is a promising strategy in patients with refractory bipolar and depressive mood disorders. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 20, 2021 Category: Endocrinology Source Type: research

Effect of systemic steroid therapy in Graves ’ orbitopathy on regulatory T cells and Th17/Treg ratio
ConclusionsTherapeutic effects of steroid therapy in Graves ’ orbitopathy are not mediated by Treg and Th17 alterations in the peripheral blood. The decrease in peripheral Treg percentage is likely a consequence of the non-specific effects of steroids and does not impact clinical outcome. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 20, 2021 Category: Endocrinology Source Type: research

Use of thyroid hormones in hypothyroid and euthyroid patients: A 2020 THESIS questionnaire survey of members of the Danish Endocrine Society
ConclusionThe treatment of choice for hypothyroidism is LT4. Combination therapy with LT4  + LT3 is considered for patients with persistent symptoms. Even in the presence of conditions affecting bioavailability, responding Danish endocrinologists prefer LT4 tablets rather than newer LT4 formulations, such as soft-gel capsules. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 20, 2021 Category: Endocrinology Source Type: research

Estimated glucose disposal rate as a candidate biomarker for thrombotic biomarkers in T1D: a pooled analysis
AbstractPurposeTo determine the utility of estimated glucose disposal rate (eGDR) as a candidate biomarker for thrombotic biomarkers in patients with type 1 diabetes (T1D).MethodsWe reanalysed baseline pretreatment data in a subset of patients with T1D from two previous RCTs, consisting of a panel of thrombotic markers, including fibrinogen, tissue factor (TF) activity, and plasminogen-activator inhibitor (PAI)-1, and TNF α, and clinical factors (age, T1D duration, HbA1c, insulin requirements, BMI, blood pressure, and eGDR). We employed univariate linear regression models to investigate associations between clinical ...
Source: Journal of Endocrinological Investigation - October 20, 2021 Category: Endocrinology Source Type: research

Diaphragma sellae sinking can predict the onset of hyponatremia after transsphenoidal surgery for pituitary adenomas
ConclusionDS sinking plays an important role in predicting hyponatremia onset after TSS for pituitary adenomas. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 20, 2021 Category: Endocrinology Source Type: research

Adrenal incidentaloma as a novel independent predictive factor for periodontitis
AbstractPurposeThere are no data regarding periodontal derangements in patients with adrenal incidentalomas (AI). We assessed the frequency and severity of periodontitis in patients with AI [non-functioning adrenal incidentaloma (NFAI) and possible autonomous cortisol secretion (ACS)] and compared with individuals with normal adrenal.MethodsA cross-sectional study evaluated thirty-five individuals with AI and 26 controls. NFAI and possible ACS diagnosis was based on the current guidelines: NFAI [cortisol levels after 1  mg dexamethasone suppression test (1 mg-DST) ≤ 1.8 µg/dL (≤&thi...
Source: Journal of Endocrinological Investigation - October 20, 2021 Category: Endocrinology Source Type: research

Autoimmune polyendocrine syndrome type 1: an Italian survey on 158 patients
ConclusionsIn Italy, APS-1 is a rare disorder presenting with the three major manifestations and associated with differentAIRE gene mutations. IFN ωAbs are markers of APS-1 and other organ-specific autoantibodies are markers of clinical, subclinical or potential autoimmune conditions. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 20, 2021 Category: Endocrinology Source Type: research

Graves ’ orbitopathy in Natalie Frank’s oeuvre
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 20, 2021 Category: Endocrinology Source Type: research

Secondary prevention of fragility fractures: where do we stand during the COVID-19 pandemic?
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 20, 2021 Category: Endocrinology Source Type: research

Dante and the goiter: a little-known medieval anecdote
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 20, 2021 Category: Endocrinology Source Type: research