Distributions of serum thyroid-stimulating hormone in 2020 thyroid disease-free adults from areas with different iodine levels: a cross-sectional survey in China
AbstractPurposeThe aim of the present study was to describe the distributions of serum thyroid- stimulating hormone (TSH) levels in thyroid disease-free adults from areas with different iodine levels in China. Meanwhile, we aimed to evaluate the influence of age and gender on the distribution of TSH, assess the relationship between concentrations of TSH and free thyroxine (FT4), and analyze the factors that may affect TSH levels.Methods2020 adults were included from April 2016 to June 2019. Urinary iodine concentration, serum iodine concentration, serum TSH, FT4, free triiodothyronine, thyroid peroxidase antibodies and thy...
Source: Journal of Endocrinological Investigation - April 15, 2021 Category: Endocrinology Source Type: research

Circulating dipeptidyl peptidase-4 is independently associated with the presence and severity of NAFLD/NASH in individuals with and without obesity and metabolic disease
ConclusionsThis study demonstrates the coexistence of increased plasma DPP4 levels and activity in NAFLD. Circulating DPP4 measurement may represent a novel cost-effective strategy for NAFLD/NASH risk stratification and a potential tool for monitoring disease ’s progression in established NAFLD. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 15, 2021 Category: Endocrinology Source Type: research

High body mass index and night shift work are associated with COVID-19 in health care workers
ConclusionsOur results describe a low prevalence of COVID-19 infection among HCWs at a central Italian COVID Hospital. COVID-19 infection risk appears to be associated with obesity and night shift work, thus supporting the need for careful health surveillance among frontline HCWs exposed to COVID-19. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 15, 2021 Category: Endocrinology Source Type: research

The role of placental iodine storage in the neonatal thyroid stimulating hormone surge: iodine as a driving force to adapt the terrestrial life
This study focuses on the role of placental iodine concentration in the TSH surge after delivery.Materials and methodsThis study included 42 mothers and their newborns, none of whom had perinatal risk factors. The following samples were collected to analyze iodine: placental tissue, amniotic fluid (AF), and 24-h maternal urine. Blood was drawn from the umbilical cord (uc), newborns (at the 1st –24th hours), and mothers (at 1st hour) to analyze the following hormones: TSH, freeT4/T3(fT4/fT3), human chorionic gonadotrophin (hCG), prolactin (PRL), follicle stimulating hormone (FSH), luteinizing hormone (LH), and cortiso...
Source: Journal of Endocrinological Investigation - April 15, 2021 Category: Endocrinology Source Type: research

Comparison of PCOS phenotypes in adolescent and young adult Mediterranean women with possible PCOS
ConclusionIn this cohort of adolescent and young adult women with PCOS, the progression of age does not change the prevalence and the features of main PCOS phenotypes. It suggests that the Rotterdam criteria might be used also in adolescents, at least in those with 2 or more years of gynecological age, for the diagnosis of PCOS. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 15, 2021 Category: Endocrinology Source Type: research

Quality of life in Klinefelter patients on testosterone replacement therapy compared to healthy controls: an observational study on the impact of psychological distress, personality traits, and coping strategies
ConclusionEndocrinologists should cooperate with mental health providers to foster a better outcome of the disease in KS patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 15, 2021 Category: Endocrinology Source Type: research

Anosmia and ageusia: a piece of the puzzle in the etiology of COVID-19-related transitory erectile dysfunction
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 15, 2021 Category: Endocrinology Source Type: research

First-line surgery in prolactinomas: lessons from a long-term follow-up study in a tertiary referral center
ConclusionsFirst-line surgery in patients with microprolactinomas or macroprolactinomas Knosp grade 0 resulted in a good chance of non-dependency on DA therapy. However, in patients with prolactinomas Knosp grade 1, first-line surgery cannot be recommended, as adjuvant DA therapy after surgery is required in the majority of them over the long term. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 13, 2021 Category: Endocrinology Source Type: research

Impact of moderate exercise on fatty acid oxidation in pancreatic β-cells and skeletal muscle
AbstractFatty acids (FA) play a crucial role in glycaemia regulation in healthy and metabolic disorders conditions through various mechanisms. FA oxidation is one of the processes involved in lipid metabolism and can be modulated by exercise. Nowadays, physical activity is known to be an effective strategy for the prevention and treatment of Type 2 Diabetes. Moreover, its intensity, its duration, the sex-gender, the prandial state, exerkines … are as many parameters that can influence glycaemic control. However, the widely debated question is to determine the best type of exercise for patients with metabolic disorde...
Source: Journal of Endocrinological Investigation - April 12, 2021 Category: Endocrinology Source Type: research

Beneficial effect of low-dose radioiodine ablation for Graves ’ orbitopathy: results of a retrospective study
ConclusionsThe advantage of total thyroid ablation seems to be a more rapid response for GO to ivGC treatment. Prospective, randomized studies in a larger number of subjects are needed to confirm our findings. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 12, 2021 Category: Endocrinology Source Type: research

Vitamin D and Vitamin D binding protein: the inseparable duo in COVID-19
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 11, 2021 Category: Endocrinology Source Type: research

First but not second postoperative day growth hormone assessments as early predictive tests for long-term acromegaly persistence
ConclusionsD1-rGH could be a highly specific test for the early diagnosis of long-term acromegaly persistence, which is predicted by a value  >  2.5 ng/mL with a great degree of certainty. The diagnostic performance of D2-rGH was insufficient. Further research is required to validate these preliminary results prior to modifying the postoperative management of acromegaly. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 10, 2021 Category: Endocrinology Source Type: research

Nodular goiter in Pontormo ’s “Epifania Benintendi” (ca. 1520)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 9, 2021 Category: Endocrinology Source Type: research

The combination of soluble tumor necrosis factor receptor type 1 and fibroblast growth factor 21 exhibits better prediction of renal outcomes in patients with type 2 diabetes mellitus
ConclusionBoth sTNFR1 and FGF-21 levels were associated with renal outcomes of in patients with type 2 diabetes, and the combination of the abovementioned markers exhibits better predictability. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 8, 2021 Category: Endocrinology Source Type: research

Negative associations of morning serum cortisol levels with obesity: the Henan rural cohort study
ConclusionMorning serum cortisol were negatively related to obesity defined by different indices in Chinese rural populations. In addition, cortisol could be as a biomarker for prediction of obesity in males. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 7, 2021 Category: Endocrinology Source Type: research

Retrospective analysis of vitamin D status on ınflammatory markers and course of the disease in patients with COVID-19 infection
ConclusionCases with lower vitamin D status had increased inflammatory markers and worse clinical outcomes than patients with higher vitamin D status. This study suggests that vitamin D status can be used as a prognostic factor in COVID-19 patients, and vitamin D supplementation can be recommended to improve the clinical outcomes in COVID-19 infection. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 5, 2021 Category: Endocrinology Source Type: research

Serum concentrations of dihydrotestosterone are associated with symptoms of hypogonadism in biochemically eugonadal men
AbstractPurposeSymptoms of hypogonadism are often reported by subjects with normal serum testosterone (T) levels. We aimed to assess the association between clinical symptoms in andrological outpatients and sex steroids levels.MethodsThis is a retrospective cross-sectional cohort study in an Academic clinic and research unit. International Index of Erectile Function (IIEF, EF domain) and Aging Males Symptoms scale (AMS) questionnaires were completed by 635 and 574 men, respectively (mean age: 47.3  ± 13.9 and 47.4 ± 13.8 years,p = 0.829), free of interfering medi...
Source: Journal of Endocrinological Investigation - April 3, 2021 Category: Endocrinology Source Type: research

Pituitary neuroendocrine tumors and differentiated thyroid cancer: do metabolic and inflammatory risk factors play roles?
ConclusionsOur findings in patients with nonacromegalic PitNETs do not indicate a high risk for DTC despite the presence of metabolic and inflammatory risk factors for neoplastic events. In contrast, acromegaly promotes a greater risk of DTC. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 10, 2021 Category: Endocrinology Source Type: research

The genetic polymorphisms of XPR1 and SCL34A3 are associated with Fanconi syndrome in Chinese patients of tumor-induced osteomalacia
In this study, we investigated the association between genetic polymorphisms of phosphate transporters in renal proximal tubules and TIO with FS.MethodsWe recruited 30 TIO patients with FS (TIO-FS) as well as 30 TIO patients (TIO-nonFS) without any urine abnormalities matched by age and gender. We collected clinical manifestations and conducted targeted sequencing ofSLC34A1,SLC34A3 and XPR1 genes and the association analysis between variants in TIO with FS and phenotypes.ResultsTIO-FS group had lower levels of serum phosphate (0.44  ± 0.12 vs. 0.51 ± 0.07 mmol/L,p 
Source: Journal of Endocrinological Investigation - March 10, 2021 Category: Endocrinology Source Type: research

Parathyroidectomy slows renal function decline in patients with primary hyperparathyroidism
AbstractPurposePrimary hyperparathyroidism has deleterious effects on health and causes nephrolithiasis and osteoporosis. However, it remains unclear whether parathyroidectomy benefits kidney function among patients with primary hyperparathyroidism.MethodsIn this retrospective study, patients with primary hyperparathyroidism receiving parathyroidectomy in a tertiary medical center between 2003 and 2017 were followed up until December 31 2017, death, or requiring renal replacement therapy. Impact of parathyroidectomy on kidney function was examined using longitudinal estimated glomerular filtration rate (eGFR) change scales...
Source: Journal of Endocrinological Investigation - March 10, 2021 Category: Endocrinology Source Type: research

Effect of 1-year oral cholecalciferol on a metabolic profile and blood pressure in poor-controlled type 2 diabetes mellitus: an open-label randomized controlled pilot study
AbstractPurposeHypovitaminosis D has been associated with many cardio-metabolic disorders, although their pathogenetic link still remains unclear. Our aim was to evaluate whether 1-year vitamin D (D) supplementation could improve glycemic control, lipid profile, systolic (SBP) and diastolic (DBP) blood pressure levels and body composition.MethodsIn an open-label randomized-controlled pilot study, thirty poor-controlled (HbA1c  >  59 mmol/mol) type 2 diabetic patients (age 71.5 ± 3.2 years, M/F 21/9, BMI 29.8 ± 3.6 kg/m2) with hypovitaminosis D (25OHD...
Source: Journal of Endocrinological Investigation - March 10, 2021 Category: Endocrinology Source Type: research

Chronic stress inhibits hypothalamus –pituitary–thyroid axis and brown adipose tissue responses to acute cold exposure in male rats
Conclusion Both types of chronic stress blunted HPT and BAT responses to cold. Long-term stress effects on noradrenergic and/or hormonal signaling are likely responsible for HPT dysfunction and not the type of chronic stressor. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 10, 2021 Category: Endocrinology Source Type: research

Incidence of heart failure in patients with type 1 diabetes: a systematic review of observational studies
AbstractBackgroundHeart failure (HF) is considered an important contributor to cardiovascular morbidity and mortality in diabetes mellitus. However, a precise identification of hyperglycemia as contributor for HF is missing.ObjectivesWe performed a review and a meta-regression of the available observational studies on the incidence of HF in type 1 diabetes (T1D).Data source and analysisWe conducted a systematic search of the literature on the incidence of HF in patients with T1D identifying suitable studies published between January 1970 and June 2018 using the following search string: “type 1 diabetes” AND, &l...
Source: Journal of Endocrinological Investigation - March 10, 2021 Category: Endocrinology Source Type: research

Serum glypican4 and glycosylphosphatidylinositol-specific phospholipase D levels are associated with adipose tissue insulin resistance in obese subjects with different glucose metabolism status
AbstractObjectivesGlypican4 (GPC4) is a novel adipokine associated with obesity and insulin resistance. GPC4 was cleaved by the glycosylphosphatidylinositol-specific phospholipase D (GPLD1) in an anchored site of the glycosylphosphatidylinositol, and then was released into the extracellular environment. Herein, we investigated the changes of serum GPC4 and GPLD1 levels in obese subjects with different glucose metabolism status and their relationship with adipose tissue insulin resistance index (Adipo-IR) in Chinese north populations.MethodsA total of 221 obese subjects and 37 normal controls (NC) were recruited in this stu...
Source: Journal of Endocrinological Investigation - March 10, 2021 Category: Endocrinology Source Type: research

What we have to know about corticosteroids use during Sars-Cov-2 infection
ConclusionPhysicians involved in the management of patients affected by COVID-19 should be aware of the need of an appropriate GC dose tapering, and of potential interaction of GCs with antiviral therapy and drugs used to treat associated co-morbidities. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 10, 2021 Category: Endocrinology Source Type: research

Controlled obesity status: a rarely used concept, but with particular importance in the COVID-19 pandemic and beyond
AbstractObesity is a chronic disease that causes and aggravates several other diseases, and early reports suggest it is an important risk factor for COVID-19 severity. Although a deeper understanding of this relationship is vital, it is also important to inform the general public about the risks and, ideally, offer strategies to mitigate the risks. As “resolution” of obesity in the short-term is not feasible, it is indeed possible that smaller weight losses and increase in physical activity can actually reduce the risks. In this context, we propose that a term called “controlled obesity” be more oft...
Source: Journal of Endocrinological Investigation - March 10, 2021 Category: Endocrinology Source Type: research

Using metabolic markers to identify insulin resistance in premenopausal women with and without polycystic ovary syndrome
ConclusionTG/HDL-C can identify IR in premenopausal women with  and/without PCOS; diagnostic cut-points differ from those of men and postmenopausal women. HDL-C is an alternative predictor in women with PCOS. These simple metabolic markers, which are standardized between labs, inexpensive, and routinely measured, can be used to tailor lifestyle and medical int erventions to improve health outcomes in insulin-resistant premenopausal women. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 9, 2021 Category: Endocrinology Source Type: research

Anti-inflammatory effects of diet and caloric restriction in metabolic syndrome
ConclusionWeight loss through caloric restriction is associated with an improvement in peripheral lipid and cytokine profiles that may play a major role in improving cardiovascular risk.Graphic abstract (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 8, 2021 Category: Endocrinology Source Type: research

Thyroid hormone action in epidermal development and homeostasis and its implications in the pathophysiology of the skin
AbstractThyroid hormones (THs) are key endocrine regulators of tissue development and homeostasis. They are constantly released into the bloodstream and help to regulate many cell functions. The principal products released by the follicular epithelial cells are T3 and T4. T4, which is the less active form of TH, is produced in greater amounts than T3, which is the most active form of TH. This mechanism highlights the importance of the peripheral regulation of TH levels that goes beyond the central axis. Skin, muscle, liver, bone and heart are finely regulated by TH. In particular, skin is among the target organs most influ...
Source: Journal of Endocrinological Investigation - March 8, 2021 Category: Endocrinology Source Type: research

Iodine nutrition optimization: are there risks for thyroid autoimmunity?
AbstractIodine deficiency is still the main cause of preventable thyroid disorders, worldwide. To optimize iodine intake, programs of voluntary or mandatory iodization of salt have been implemented in several iodine-deficient countries and iodine sufficiency has been achieved in many. Despite the clear beneficial effects on thyroid health, some concerns have been raised on the presumed detriment of iodine prophylaxis on thyroid autoimmunity. Very recent studies aimed at evaluating the long-term consequences of iodine supplementation on thyroid autoimmunity and related dysfunction, have clearly demonstrated that the early p...
Source: Journal of Endocrinological Investigation - March 8, 2021 Category: Endocrinology Source Type: research

Growth hormone deficiency and other endocrinopathies after childhood brain tumors: results from a close follow-up in a cohort of 242 patients
ConclusionThis study reveals a higher prevalence of endocrinopathies in brain tumors survivors and explores the influence of craniospinal irradiation in the adult body proportions. It reinforces the importance of routine follow-up among survivors. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 8, 2021 Category: Endocrinology Source Type: research

Maximum adenoma diameter, regardless of uni- or bilaterality, is a risk factor for autonomous cortisol secretion in adrenal incidentalomas
AbstractPurposeTo evaluate differences between patients with unilateral and  bilateral adrenal incidentalomas (AIs) in the prevalence of autonomous cortisol secretion (ACS) and related comorbidities.MethodsIn this multicentre retrospective study, AIs  ≥ 1 cm without overt hormonal excess were included in the study. ACS was defined by a post-dexamethasone suppression test (DST) serum cortisol ≥ 5.0 µg/dl, in the absence of signs of hypercortisolism. For the association of ACS with the prevalence of comorbidities, post-DST serum cor tisol was also analysed as a continuou...
Source: Journal of Endocrinological Investigation - March 8, 2021 Category: Endocrinology Source Type: research

Challenges of CYP21A2 genotyping in children with 21-hydroxylase deficiency: determination of genotype –phenotype correlation using next generation sequencing in Southeastern Anatolia
ConclusionThis study revealed that the concordance rates of the severe genotypes with their phenotypes were good, while those of the milder genotypes were poor. The discrepancies could have resulted from the complex characteristics of 21-OHD genotyping and the limitations of using NGS alone without integrating with other comprehensive methods. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 6, 2021 Category: Endocrinology Source Type: research

Effects of competitive physical activity on serum irisin levels and bone turnover markers
AbstractBackgroundIrisin, a myokine, is a polypeptide derived from the cleavage of the extracellular domain of fibronectin domain-containing protein 5, a receptor that is present on different tissues (skeletal muscle, pericardium, myocardium, and brain), whose functions are not yet fully defined.PurposeThe main aim of our study was to evaluate the effect of competitive physical activity on serum irisin levels and bone turnover markers.MethodsFifteen male footballers and an equal number of subjects of the same age and gender, but with a predominantly sedentary lifestyle, had their serum levels of irisin and bone turnover ma...
Source: Journal of Endocrinological Investigation - March 6, 2021 Category: Endocrinology Source Type: research

The “Ensign Nun” Catalina de Erauso: a clinical endocrinology enigma
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 6, 2021 Category: Endocrinology Source Type: research

Vitamin D deficiency, secondary hyperparathyroidism and respiratory insufficiency in hospitalized patients with COVID-19
AbstractPurposeHypovitaminosis D has emerged as potential risk factor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the general population with variable effects on the outcome of the coronavirus disease-19 (COVID-19). The aim of this retrospective single-center study was to investigate the impact of hypovitaminosis D and secondary hyperparathyroidism on respiratory outcomes of COVID-19.MethodsThree-hundred-forty-eight consecutive patients hospitalized for COVID-19 at the IRCCS Humanitas Research Hospital, Rozzano, Milan (Italy) were evaluated for arterial partial pressure oxygen (PaO2)/fract...
Source: Journal of Endocrinological Investigation - March 5, 2021 Category: Endocrinology Source Type: research

POR polymorphisms are associated with 21 hydroxylase deficiency
AbstractPurposeGenotype –phenotype correlation in congenital 21 hydroxylase deficiency is strong but by no means absolute. Indeed, clinical and hormonal features may vary among patients carrying similarCYP21A2 mutations, suggesting that modifier genes may contribute to the phenotype. Aim of the present study was to evaluate whether polymorphisms in the p450  oxidoreductase (POR) gene may affect clinical features in patients with 21 hydroxylase deficiencyMethodsSequencing of thePOR gene was performed in 96 patients with 21 hydroxylase deficiency (49 classic, 47 non-classic) and 43 control subjects.ResultsPrevalen...
Source: Journal of Endocrinological Investigation - March 5, 2021 Category: Endocrinology Source Type: research

Volumetric evaluation of CT images of adrenal glands in primary aldosteronism
AbstractObjectivesTo investigate whether adrenal volumetry provides better agreement with adrenal vein sampling (AVS) than conventional CT for subtyping PA. Furthermore, we evaluated whether the size of this contralateral adrenal was a prognostic factor for clinical outcome after unilateral adrenalectomy.MethodsWe retrospectively analyzed volumes of both adrenal glands of the 180 CT-scans (88/180 with unilateral and 92/180 with bilateral disease) of the patients with PA included in the SPARTACUS trial of which 85 also had undergone an AVS. In addition, we examined CT-scans of 20 healthy individuals to compare adrenal volum...
Source: Journal of Endocrinological Investigation - March 5, 2021 Category: Endocrinology Source Type: research

PDE11A gene polymorphism in testicular cancer: sperm parameters and hormonal profile
ConclusionsOur findings highlight the key role ofPDE11A in testis and suggest the presence of an underlying complex and fine molecular mechanism which controls testis-specific gene expression and susceptibility to testicular cancer. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 4, 2021 Category: Endocrinology Source Type: research

The genetic background and vitamin D supplementation can affect irisin levels in Prader –Willi syndrome
ConclusionWe demonstrated the possible role of genetic background and vitamin-D supplementation on irisin serum levels in PWS patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 3, 2021 Category: Endocrinology Source Type: research

Risk of preoperative understaging of duodenal neuroendocrine neoplasms: a plea for caution in the treatment strategy
ConclusionsConventional imaging has a poor detection rate for loco-regional nodes and micrometastases in the presurgical setting of the dNENs. These results represent important advice when local conservative approaches, such as endoscopy or local surgical excision are considered and it represents a strong recommendation to include endoscopic ultrasound in the preoperative tools for a more accurate local staging. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 2, 2021 Category: Endocrinology Source Type: research

Identification of circulating biomarkers for differentiating patients with papillary thyroid cancers from benign thyroid tumors
ConclusionsWe identified seven downregulated circulating lncRNAs with the potential for predicting the occurrence of papillary thyroid cancers. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 1, 2021 Category: Endocrinology Source Type: research

Glucagon stimulation test to assess growth hormone status in Prader –Willi syndrome
AbstractPurposeGrowth hormone deficiency (GHD) must be confirmed before starting treatment in adults with Prader-Willi syndrome (PWS). Most studies use the growth-hormone-releasing hormone plus arginine (GHRH-arginine) test. No data are available on the glucagon stimulation test (GST) in PWS. We compared the utility of fixed-dose (1  mg) GST versus GHRH-arginine test in diagnosing GHD.MethodsAdults and late adolescents with PWS underwent both tests on separate days. In the GHRH-arginine test, GHD was defined according to body mass index. In the GST, two cutoffs were analyzed: peak GH concentration    90&...
Source: Journal of Endocrinological Investigation - February 12, 2021 Category: Endocrinology Source Type: research

Bilateral testicular masses and adrenal insufficiency: is congenital adrenal hyperplasia the only possible diagnosis? First two cases of TARTS described in Addison-only X-linked adrenoleukodystrophy and a brief review of literature
ConclusionThese are the first cases reported of TARTs in patients with X-ALD-associated PAI. Testicular lesions in patients with an early onset of ACTH elevation, regardless of the cause, should always be thoughtfully investigated, as they may reveal themselves as TARTs. We suggest that all patients affected from chronic ACTH elevation of a young age of onset should undergo testicular ultrasound in order to evaluate the presence of these lesions. GRT in these patients might also help preserving fertility. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 12, 2021 Category: Endocrinology Source Type: research

Activation of central galanin receptor 2 mitigated insulin resistance in adipocytes of diabetic rats
ConclusionThose results suggest that central GAL2-R mediates the beneficial effects of galanin on insulin sensitivity in type 2 diabetic rats. GAL2-R agonist may be taken as a potential antidiabetic agent to treat insulin resistance and type 2 diabetes. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 12, 2021 Category: Endocrinology Source Type: research

Association between lower plasma adiponectin levels and higher plasma thrombin generation parameters in men with type 2 diabetes: role of plasma triglycerides
ConclusionOur findings show for the first time the existence of a significant association between lower levels of plasma adiponectin and greater plasma thrombin generation (as assessed by the ST Genesia ® analyzer) in men with non-insulin-treated T2DM, which appears to be largely mediated by plasma triglycerides. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 12, 2021 Category: Endocrinology Source Type: research

The prevalence of silent acromegaly in prolactinomas is very low
AbstractPurposeThe aim of this study was to evaluate the somatotroph axis in a large series of patients with prolactinoma to verify the prevalence of silent acromegaly in this population.MethodsA hundred and forty-four patients were enrolled in a multicenter study: 90 were already on cabergoline (CAB) and enrolled in a cross-sectional arm (group A) with random PRL, GH and IGF-I determination on treatment ( ≥ 3 months), whereas 54 untreated patients were enrolled at diagnosis in a prospective arm (group B) with PRL, GH and IGF-I measurement before and after 6 and 12 months of treatment. In the presence of ...
Source: Journal of Endocrinological Investigation - February 12, 2021 Category: Endocrinology Source Type: research

Dysthyroid optic neuropathy: evaluation and management
ConclusionsAlthough DON may cause vision loss, most cases are reversible if recognized and managed in a timely manner. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 12, 2021 Category: Endocrinology Source Type: research

Skeletal health in patients with differentiated thyroid carcinoma
AbstractOsteoporosis and fractures are important comorbidities in patients with differentiated thyroid cancer (DTC), with potential negative impact on quality of life and survival. The main determinant of skeletal fragility in DTC is the thyrotropin (TSH)-suppressive therapy, which is commonly recommended to prevent disease ’s recurrence, especially in patients with structural incomplete response after thyroid surgery and radio-iodine therapy. TSH-suppressive therapy can stimulate bone resorption with consequent bone loss, deterioration of bone microstructure and high risk of fragility fractures. The skeletal effects...
Source: Journal of Endocrinological Investigation - February 12, 2021 Category: Endocrinology Source Type: research

Efficacy and safety of hydroxychloroquine as add-on therapy in uncontrolled type 2 diabetes patients who were using two oral antidiabetic drugs
AbstractObjectiveTo evaluate the Safety and Efficacy of Hydroxychloroquine as add-on therapy in uncontrolled type 2 diabetes patients who were using two oral antidiabetic drugs.Materials and methodsThis was a double blind, placebo controlled, parallel group study in 304 inadequately controlled type 2 diabetes (T2DM) subjects with two oral antidiabetic drugs (glimepiride 4  mg and metformin 500 mg) were randomised to hydroxychloroquine (HCQ) 200 mg, 300 mg, 400 mg once daily (OD) or placebo. Dose of hydroxychloroquine was selected as per body weight of the subject. Primary end point was glycated hae...
Source: Journal of Endocrinological Investigation - February 12, 2021 Category: Endocrinology Source Type: research