Metabolic syndrome is associated to an increased risk of low bone mineral density in free-living women with suspected osteoporosis
ConclusionsThe significant association between Op and MetS in free-living women examined by DXA for suspected Op suggests the advisability of a contextual evaluation of both disorders in this setting. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 22, 2020 Category: Endocrinology Source Type: research

Plasma dosage of ghrelin, IGF-1, GLP-  1 and leptin related to gastric emptying and esophageal pH-impedance in children with obesity
ConclusionAlthough we found an association between auxological parameters and both leptin and ghrelin levels, this association did not imply an effect on the upper GI motility. Therefore, our hypothesis that alterations of these hormones in children with obesity could affect gastric emptying, triggering GERD, was not supported by our data. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 22, 2020 Category: Endocrinology Source Type: research

Revisiting peak serum cortisol response to insulin-induced hypoglycemia in children
ConclusionOur data indicate that the current cut-off to define normal HPA axis response in children after insulin-induced hypoglycemia warrants reevaluation to avoid over-diagnosis of adrenal insufficiency. Our results suggest that peak serum cortisol levels  ≥ 15.4 µg/dL (428 nmol/L) in children undergoing ITT might represent a normal cortisol response to stress, regardless of age, BMI or GH secretory capacity. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 21, 2020 Category: Endocrinology Source Type: research

Letter to the Editor: “COVID‐19 and the endocrine system: exploring the unexplored”. Focus on acromegaly
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 21, 2020 Category: Endocrinology Source Type: research

Alterations of gut microbiota composition in post-finasteride patients: a pilot study
ConclusionGut microbiota population is altered in PFS patients, suggesting that it might represent a diagnostic marker and a possible therapeutic target for this syndrome. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 19, 2020 Category: Endocrinology Source Type: research

Impact of COVID-19 pandemic on psychophysical stress in patients with adrenal insufficiency: the CORTI-COVID study
AbstractPurposeCOVID-19 is a novel threat to patients with adrenal insufficiency (AI), whose life expectancy and quality (QoL) are impaired by an increased risk of infections and stress-triggered adrenal crises (AC). If infected, AI patients require prompt replacement tailoring. We assessed, in a cohort of AI patients: prevalence and clinical presentation of COVID-19; prevalence of AC and association with intercurrent COVID-19 or pandemic-related psychophysical stress; lockdown-induced emotional burden, and health-related QoL.MethodsIn this monocentric (Ancona University Hospital, Italy), cross-sectional study covering Feb...
Source: Journal of Endocrinological Investigation - September 18, 2020 Category: Endocrinology Source Type: research

Dihydrotestosterone (DHT) rapidly increase after maximal aerobic exercise in healthy males: the lowering effect of phosphodiesterase ’s type 5 inhibitors on DHT response to exercise-related stress
ConclusionsIn addition to testosterone, also DHT plays an exercise-related adaptive role during high intensity aerobic exercise, but its rapid useful effects during exercise have to be determined. We hypothesized that the increased androgens secretion during exercise could be mainly related to steroidogenic enzymes modifications in peripheral tissues (i.e., muscles). Moreover, the blunting effect of tadalafil on DHT increase support a possible role of peripheral nitric oxide/GMPc related pathways in influencing physical-stress related DHT metabolism. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 18, 2020 Category: Endocrinology Source Type: research

Gender susceptibility to COVID-19: a review of the putative role of sex hormones and X chromosome
ConclusionsBoth mechanisms consistently point to the role of sex hormones and sex chromosomes in the differential severity and lethality of COVID-19 in men and women. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 16, 2020 Category: Endocrinology Source Type: research

MiR-21-5p in macrophage-derived extracellular vesicles affects podocyte pyroptosis in diabetic nephropathy by regulating A20
ConclusionMiR-21-5p in macrophage-derived EVs can regulate pyroptosis-mediated podocyte injury by A20 in DN. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 15, 2020 Category: Endocrinology Source Type: research

The association between hypoparathyroidism and cognitive impairment: a systematic review
ConclusionEven though mostly based on single case reports, the presence of neuropsychological dysfunctions in the context of HPT appears to be a consistent core finding. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 14, 2020 Category: Endocrinology Source Type: research

COVID-19 in Cushing disease: experience of a single tertiary centre in Lombardy
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 11, 2020 Category: Endocrinology Source Type: research

SARS-COV-2 as a trigger for autoimmune disease: report of two cases of Graves ’ disease after COVID-19
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 10, 2020 Category: Endocrinology Source Type: research

Unveiling Charles II, the last King of the Habsburg Spanish Empire, in a portrait by Juan Carre ño de Miranda (1685)
ConclusionPossible endocrinological diseases have been hypothesized. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 10, 2020 Category: Endocrinology Source Type: research

At the origin of “Endocrinology and Art”: Woman’s Head (third century BCE)
AbstractIn 1911, the Danish physician Hans Christian Gram  (1853–1938) sustained to have found signs of hyperthyroidism in a marble head of a Roman woman that he observed in the Ny Carlsberg Glyptotek in Copenhagen. It could be one of the first examples of a clinical diagnosis of an endocrine disease in an ancient statue. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 10, 2020 Category: Endocrinology Source Type: research

Mother with child (1921): a Graves ’ disease painted by Otto Dix
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 10, 2020 Category: Endocrinology Source Type: research

Cardiometabolic index: a new tool for screening the metabolically obese normal weight phenotype
ConclusionsCMI could be served as a valuable indicator to identify MONW phenotype of Chinese adults, particularly for young people. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 9, 2020 Category: Endocrinology Source Type: research

Uncommon tumors in multiple endocrine neoplasia (MEN) type 1: Do they have a relationship with the prognosis of these patients?
ConclusionsTo conclude, 75% of MEN-related deaths were the result of an uncommon pathology, and we, therefore, recommend that these tumors should be taken into account in the screening and follow-up of these patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 9, 2020 Category: Endocrinology Source Type: research

HbA1c variability as an independent predictor of diabetes retinopathy in patients with type 2 diabetes
AbstractAimsTo evaluate the association of both mean HbA1c and HbA1c variability with DR development in patients with type 2 diabetes.MethodsPatients with type 2 diabetes who received dilated funduscopic examination annually and who underwent at least 2-year follow-up were included in this longitudinal study. Subjects were excluded if they took less than five HbA1c measurements during the follow-up period. HbA1C variability was expressed as A1c-SD, and the mean of HbA1c (A1c-Mean) was calculated. In addition, medical history and clinical data of all subjects were collected and analyzed. According to A1c-Mean above or below...
Source: Journal of Endocrinological Investigation - September 8, 2020 Category: Endocrinology Source Type: research

Prevalence, predictors and outcomes of thyroid dysfunction in patients with acute myocardial infarction: the ThyrAMI-1 study
ConclusionsThyroid dysfunction is common in AMI patients on admission to hospital and our data provide an understanding regarding which factors might influence thyroid dysfunction in these patients. Furthermore, the negative association between LT3S and increased mortality post-AMI has once again been highlighted by this study. More research is required to assess if treatment of thyroid dysfunction improves clinical outcomes. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 8, 2020 Category: Endocrinology Source Type: research

Is there any gender difference in epidemiology, clinical presentation and co-morbidities of non-functioning pituitary adenomas? A prospective survey of a National Referral Center and review of the literature
AbstractPurposeGender differences in patients diagnosed with non-functioning Pituitary Adenomas (NFPA) in a National Referral Center for Pituitary Tumors at the Federico II University of Naples, Italy.MethodsPatients newly diagnosed with non-functioning sellar masses found on pituitary Magnetic Resonance Imaging from January 1st 2016 to December 31th 2018 underwent anthropometric measurements, basal evaluation of pituitary function, and metabolic assessment. Fatty live index (FLI) and visceral adiposity index (VAI) were calculated.ResultsSeventy-three patients (35 males, 51.1  ± 17.0 years; 38 fem...
Source: Journal of Endocrinological Investigation - September 7, 2020 Category: Endocrinology Source Type: research

Cardiometabolic health, visceral fat and circulating irisin levels: results from a real-world weight loss study
ConclusionsIn this real-world evidence study, a successful weight loss achieved only 26% of patients, with overall much better adherence to diet restriction than to exercise. However, even mild to moderate weight loss resulted in significant improvements in cardiometabolic health. Weight loss was associated with a modest LM decrease but did not influence plasma irisin. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 6, 2020 Category: Endocrinology Source Type: research

A tool to predict survival in stage IV entero-pancreatic NEN
AbstractPurposeWell-differentiated stage IV neuroendocrine neoplasms (NEN) have an extremely heterogeneous, unpredictable clinical behavior. Survival prognostic markers, such as the recently proposed NEP-Score, would be very useful for better defining therapeutic strategies. We aim to verify NEP-Score applicability in an independent cohort of stage IV well-differentiated (WD) gastroentero-pancreatic (GEP) NEN, and identify a derivate prognostic marker taking into account clinical and pathological characteristics at diagnosis.MethodsAge, site of primary tumor, primary tumor surgery, symptoms, Ki67, timing of metastases of 2...
Source: Journal of Endocrinological Investigation - September 6, 2020 Category: Endocrinology Source Type: research

The androgyny of Christ
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 5, 2020 Category: Endocrinology Source Type: research

The immune-modulatory effects of exercise should be favorably harnessed against COVID-19
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 3, 2020 Category: Endocrinology Source Type: research

Thyroid surgery during coronavirus-19 pandemic phases I, II and III: lessons learned in China, South Korea, Iran and Italy
ConclusionThe Covid19 outbreak reduced thyroid surgery patient volumes. The decrease of Covid19 emergency plans contributed to unexpected outcomes (reduction of early stage cancer treatment, decreased operative times and hospital stays, increased VCP rate). (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 2, 2020 Category: Endocrinology Source Type: research

Prediction of heparin binding of mutated short sequences of rat thyroglobulin
AbstractBackgroundBinding of thyroglobulin (Tg) to heparin is involved in Tg transcytosis via megalin. Rat Tg (rTg) binds to heparin through an exposed carboxyl terminal region (RELPSRRLKRPLPVK, Arg2489-Lys2503) rich in positively charged residues. This region is not entirely conserved in human Tg (hTg) (Arg2489-Glu2503, REPPARALKRSLWVE), resulting in lower affinity binding. Here, we developed a score to predict to what extent secondary structure modifications affect the heparin-binding ability of rTg.MethodsWe designed eight synthetic peptides, including one with the Arg2489-Lys2503 sequence of rTg (rTgP), one with the co...
Source: Journal of Endocrinological Investigation - September 2, 2020 Category: Endocrinology Source Type: research

Mesenchymal stem cells-originated exosomal microRNA-152 impairs proliferation, invasion and migration of thyroid carcinoma cells by interacting with DPP4
ConclusionExosomal miR-152 inhibited proliferation, migration and invasion of THCA cells by binding with DPP4, which may represent a novel target for the treatment of THCA. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 2, 2020 Category: Endocrinology Source Type: research

A case of thyroidectomy in the Charaf ed-Din's manuscript (1465)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 1, 2020 Category: Endocrinology Source Type: research

Influence of body mass index on the clinicopathological features of 13,995 papillary thyroid tumors
ConclusionThe results of our study confirm that higher BMI is significantly associated with aggressive clinicopathological features of PTC. Gender differences were present with obesity ratios and aggressive clinicopathological features being significantly higher in men. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 17, 2020 Category: Endocrinology Source Type: research

Impact of the SARS-CoV2 pandemic dissemination on the management of neuroendocrine neoplasia in Italy: a report from the Italian Association for Neuroendocrine Tumors  (Itanet)
AbstractIntroductionThe organization of the healthcare system has significantly changed after the recent COVID-19 outbreak, with a negative impact on the management of oncological patients. The present survey reports data collected by the Italian Association for Neuroendocrine Tumors on the management of patients with neuroendocrine neoplasia (NEN) during the pandemic dissemination.MethodsA survey with 57 questions was sent to NEN-dedicated Italian centers regarding the management of patients in the period March 9, 2020, to May 9, 2020ResultsThe main modification in the centers ’ activity consisted of decreases in ne...
Source: Journal of Endocrinological Investigation - August 16, 2020 Category: Endocrinology Source Type: research

Outcome and diagnostic reproducibility of the thyroid cytology “indeterminate categories” SIAPEC/SIE 2014 in a consecutive series of 302 cases
ConclusionsIn this real-life experience, the sub-classification of TIR3A and TIR3B slightly increased the overall prevalence of “indeterminate” diagnoses. Malignancy rates were higher than estimated for both TIR3A and TIR3B categories. Agreement among observers highly depended on pathologist’s training. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 14, 2020 Category: Endocrinology Source Type: research

An overview of retrosternal goiter
AbstractGoiters tend to grow slowly and steadily over many years, occasionally reaching the mediastinum and extending through the thoracic inlet into the visceral compartment. In most cases, retrosternal goiters originate from the cervical portion of the thyroid. The incidence of retrosternal goiters varies considerably, ranging from 0.2 to 45% of all thyroidectomies, depending on the criteria used to define this type of goiter. Symptoms are generally related to the compressive nature of the mass on the adjacent structures, and most patients report some form of respiratory manifestation associated with the goiter. A diagno...
Source: Journal of Endocrinological Investigation - August 11, 2020 Category: Endocrinology Source Type: research

What factors have impact on glucocorticoid replacement in adrenal insufficiency: a real-life study
ConclusionsOur real-life study demonstrated the influence of etiology of AI on the type of GC used, a weight-based tailoring in sAI, a likely overdosage of GC treatment in pAI women at the start of treatment and the possibility to successfully increase FCA avoiding GC over-treatment. These observations could inform the usual clinical practice. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 10, 2020 Category: Endocrinology Source Type: research

Sex-dependent associations of maternal androgen levels with offspring BMI and weight trajectory from birth to early childhood
ConclusionOur findings provide evidence that maternal androgens may have differential effects on the programming of intrauterine growth and postnatal weight gain depending on fetal sex. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 10, 2020 Category: Endocrinology Source Type: research

Impact of diabetes on COVID-19-related in-hospital mortality: a retrospective study from Northern Italy
ConclusionIn this retrospective single-center study, diabetes was independently associated with a higher in-hospital mortality. More intensive surveillance of patients with this condition is to be warranted. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 10, 2020 Category: Endocrinology Source Type: research

Reference ranges of late-night salivary cortisol and cortisone measured by LC –MS/MS and accuracy for the diagnosis of Cushing’s syndrome
ConclusionLC –MS/MS is the most accurate analytical platform for measuring salivary steroids. Obtained reference intervals are coherent with previously published data and diagnostic accuracy for diagnosis of overt hypercortisolism proved highly satisfactory. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 9, 2020 Category: Endocrinology Source Type: research

Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19
ConclusionsHigh prevalence of hypovitaminosis D was found in COVID-19 patients with acute respiratory failure, treated in a RICU. Patients with severe vitamin D deficiency had a significantly higher mortality risk. Severe vitamin D deficiency may be a marker of poor prognosis in these patients, suggesting that adjunctive treatment might improve disease outcomes. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 9, 2020 Category: Endocrinology Source Type: research

Maternal and fetal vitamin D and their roles in mineral homeostasis and fetal bone development
AbstractDuring pregnancy, female physiology adapts to meet the additional mineral demands of the developing fetus. Meanwhile, the fetus actively transports minerals across the placenta and maintains high circulating levels to mineralize the rapidly developing skeleton. Most of this mineral is accreted during the last trimester, including 30  g of calcium, 20 g of phosphate and 0.8 g of magnesium. Given the dependence of calcium homeostasis on vitamin D and calcitriol in the adult and child, it may be expected that vitamin D sufficiency would be even more critical during pregnancy and fetal development. Howev...
Source: Journal of Endocrinological Investigation - August 9, 2020 Category: Endocrinology Source Type: research

Testosterone treatment is associated with reduced adipose tissue dysfunction and nonalcoholic fatty liver disease in obese hypogonadal men
ConclusionsThe present data suggest that TTh in severely obese, hypogonadal individuals induces metabolically healthier preadipocytes, improving insulin sensitivity, mitochondrial functioning and lipid handling. A potentially protective role for testosterone on the progression of NAFLD, improving hepatic steatosis and reducing intrahepatic triglyceride content, was also envisaged.Clinical Trial RegistrationClinicalTrials.gov Identifier: NCT02248467, September 25th 2014 (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 8, 2020 Category: Endocrinology Source Type: research

Autoimmune polyendocrine syndrome type 1 (APECED) in the Indian population: case report and review of a series of 45 patients
ConclusionWith the inherent limitations of a retrospective study, analysis of Indian APECED patients suggested that compared to classic criteria, application of Ferre/Lionakis criteria validated in North/South American patients could help in earlier diagnosis in 3 of 8 (37.5%) patients for whom adequate information for evaluation was available. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 7, 2020 Category: Endocrinology Source Type: research

[ 18 F]FDG-PET/CT and long-term responses to everolimus in advanced neuroendocrine neoplasia
ConclusionsEverolimus is a valid therapeutic option for advanced, progressive, well-differentiated NEN, even in patients with positive FDG-PET findings. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 7, 2020 Category: Endocrinology Source Type: research

Thyrotropin receptor antibodies and Graves ’ orbitopathy
ConclusionMeasurement of functional TSHR-Ab, especially TSAb, is clinically relevant for the differential diagnosis and management of GO. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 4, 2020 Category: Endocrinology Source Type: research

Bone metastases from differentiated thyroid carcinoma: current knowledge and open issues
AbstractBone represents the second most common site of distant metastases in differentiated thyroid cancer (DTC). The clinical course of DTC patients with bone metastases (BM) is quite heterogeneous, but generally associated with low survival rates. Skeletal-related events might be a serious complication of BM, resulting in high morbidity and impaired quality of life. To achieve disease control and symptoms relief, multimodal treatment is generally required: radioiodine therapy, local procedures —including surgery, radiotherapy and percutaneous techniques—and systemic therapies, such as kinase inhibitors and an...
Source: Journal of Endocrinological Investigation - August 3, 2020 Category: Endocrinology Source Type: research

The Virgin Mary with a small goiter breastfeeding the Child
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 1, 2020 Category: Endocrinology Source Type: research

SARS-CoV-2 infection, male fertility and sperm cryopreservation: a position statement of the Italian Society of Andrology and Sexual Medicine (SIAMS) (Societ à Italiana di Andrologia e Medicina della Sessualità)
ConclusionData derived from other SARS-CoV infections suggest that in patients recovered from COVID-19, especially for those in reproductive age, andrological consultation and evaluation of gonadal function including semen analysis should be suggested. Studies in larger cohorts of currently infected subjects are warranted to confirm (or exclude) the presence of risks for male gametes that are destined either for cryopreservation in liquid nitrogen or for assisted reproduction techniques. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 16, 2020 Category: Endocrinology Source Type: research

Basal ganglia calcification in hypoparathyroidism and pseudohypoparathyroidism: local and systemic metabolic mechanisms
AbstractBackgroundHypoparathyroidism and pseudohypoparathyroidism are rare disorders of mineral metabolism which may be associated with soft tissue calcification in the basal ganglia in the brain, and occasionally the skin and other tissues. The basal ganglia are the most common sites of calcification in the central nervous system in these disorders, and were first associated with this manifestation in a report from the Mayo Clinic in 1939. The reasons why the basal ganglia are a common site of soft tissue calcification in these rare disorders has been a matter of investigation for many years.FindingsDue to recent increase...
Source: Journal of Endocrinological Investigation - July 13, 2020 Category: Endocrinology Source Type: research

Addressing male sexual and reproductive health in the wake of COVID-19 outbreak
ConclusionCOVID-19 survivors might develop sexual and reproductive health issues. Andrological assessment and tailored treatments should be considered in the follow-up. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 13, 2020 Category: Endocrinology Source Type: research

Basal and stimulated calcitonin for the diagnosis of medullary thyroid cancer: updated thresholds and safety assessment
ConclusionsRefined cut-offs for bCT and casCT in patients with nodular goiter are reported. Sensitive bCT was shown to have a high accuracy, but the combination with casCT data was needed to identify all MTC cases. The reliability and safety of calcium test strongly favour the routine use of CT determination in nodular thyroid disease. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 12, 2020 Category: Endocrinology Source Type: research

Recurrence-free survival after total thyroidectomy and lobectomy in patients with papillary thyroid microcarcinoma
ConclusionThe present meta-analysis demonstrates excellent, long-term recurrence-free survival following both total thyroidectomy and lobectomy surgery in patients with papillary thyroid microcarcinoma. The analysis also suggests that patients undergoing total thyroidectomy trended toward a slightly better long-term 10-year recurrence-free survival in comparison to patients undergoing lobectomy, a finding of potential, clinical significance in the management decision-making process. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 10, 2020 Category: Endocrinology Source Type: research

PREDIM index: a useful tool for the application of the euglycemic hyperinsulinemic clamp
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 10, 2020 Category: Endocrinology Source Type: research