Increased aortic stiffness index in patients with type 1 diabetes without cardiovascular disease compared to controls
ConclusionThis study strongly suggests that patients with type 1 diabetes develop aortic root stiffness in the absence of cardiovascular diseases. This alteration may be part of a more generalized arterial dysfunction in type 1 diabetes. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 16, 2019 Category: Endocrinology Source Type: research

Comparative assessment of hypothalamic-pituitary-adrenal axis suppression secondary to intrabursal injection of different glucocorticoids: a pilot study
AbstractBackground Hypothalamic-pituitary-adrenal axis (HPAA) suppression is the most common and dangerous, although often unrecognized and untreated, side effect of glucocorticoid administration. The risk and duration depend both on patient and treatment characteristics. High-performance liquid chromatography-tandem mass spectrometry (HPLC –MS/MS) currently represents the gold standard method to evaluate the metabolism of endogenous and exogenous steroids.ObjectiveTo assess prevalence, severity, and duration of HPAA suppression subsequent to the injection of two steroids with equivalent potency but different pharm...
Source: Journal of Endocrinological Investigation - March 15, 2019 Category: Endocrinology Source Type: research

Decrease of FGF19 contributes to the increase of fasting glucose in human in an insulin-independent manner
AbstractPurposeThe ileum-derived fibroblast growth factor 19 (FGF19) plays key roles in hepatic glucose homeostasis in animals in an insulin-independent manner. Here, we analyzed the association of FGF19 with glucose effectiveness (GE, the insulin-independent glucose regulation), as well as hepatic glucose production (HGP) in Chinese subjects.MethodsGE was measured by frequently sampled intravenous glucose tolerance test (FSIVGTT) in normal glucose tolerance (NGT), isolated-impaired glucose tolerance (I-IGT), and isolated-impaired fasting glucose (I-IFG) subjects. The oral glucose tolerance test-derived surrogate of GE (oG...
Source: Journal of Endocrinological Investigation - March 9, 2019 Category: Endocrinology Source Type: research

Vitamin D status and non-alcoholic fatty liver disease in patients with type 1 diabetes
AbstractPurposeIn patients with type 1 diabetes (T1D), the prevalence of non-alcoholic fatty liver disease (NAFLD) ranges from 10 to 53% and contrasting evidence suggests that vitamin D deficiency may favor liver fat accumulation. Here, we investigated the association between vitamin D status and NAFLD in adults with T1D.Methods220 consecutive adult T1D patients on multiple daily injections or continuous subcutaneous insulin infusion and not taking calcium or vitamin D supplements were included. Patient characteristics, 25(OH)D serum levels, and metabolic parameters were analyzed. Vitamin D status was defined as sufficienc...
Source: Journal of Endocrinological Investigation - March 7, 2019 Category: Endocrinology Source Type: research

The resting metabolic rate in women with polycystic ovary syndrome and its relation to the hormonal milieu, insulin metabolism, and body fat distribution: a cohort study
ConclusionsThe higher prevalence of obesity, which negatively influences the reproductive and general health of PCOS women, could be related to factors other than an intrinsic alteration of the RMR. Further studies are needed to clarify the possible role of the visceral fat in modulating the energy balance in PCOS.Trial registration numberclinicaltrials.gov Identifier NCT03132545. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 7, 2019 Category: Endocrinology Source Type: research

Genome-wide meta-analysis identifies novel loci associated with free triiodothyronine and thyroid-stimulating hormone
ConclusionWe identified a first genome-wide significant variant associated with fT3 plasma levels, as well as a novel locus associated with TSH plasma levels. These findings are biologically relevant and enrich our knowledge about the genetic basis of pituitary-thyroid axis function. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 7, 2019 Category: Endocrinology Source Type: research

First-year predictors of health-related quality of life changes in short-statured children treated with human growth hormone
ConclusionIn conclusion, a substantial percentage of explained variance in HRQOL relates to psychosocial and sociodemographic predictors. However, there appears to be other important factors that are predictors of HRQOL, which need to be determined in large, population-based samples. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 6, 2019 Category: Endocrinology Source Type: research

Changes in left ventricular repolarization after short-term testosterone replacement therapy in hypogonadal males
AbstractBackground and aimEvidences suggest that androgen deficiency is associated with sudden cardiac death (SCD). Our purpose was to analyse some electrocardiographic (ECG) markers of repolarization phase in hypogonadal patients either at baseline or after testosterone replacement therapy (TRT).Patients and MethodsBaseline and after 6 months of testosterone replacement therapy, 14 hypogonadal patients and 10 age-matched controls underwent a short-term ECG recordings at rest and immediately after a maximal exercise test. The following ECG parameters have been collected: QTe (the interval between the q wave the end of T wa...
Source: Journal of Endocrinological Investigation - March 5, 2019 Category: Endocrinology Source Type: research

Comprehensive genotyping of Turkish women with hirsutism
Conclusion21OHD-NCAH prevalence was determined to be ~4%. Unexpectedly, high heterozygous mutation rates were observed in CYP11B1 gene and CYP21A2 promoter region. CYP11B1 and HSD3B2 deficiencies were not prevalent in Turkish women with hirsutism despite the existence of higher heterozygous mutation rate in CYP11B1. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 27, 2019 Category: Endocrinology Source Type: research

Reliability of calcium –phosphorus (Ca/P) ratio as a new, accurate and inexpensive tool in the diagnosis of some Ca–P disorders
AbstractPurposeThe serum calcium/phosphorus (Ca/P) ratio is an accurate tool to differentiate patients with primary hyperparathyroidism (PHPT) from healthy subjects. However, other disorders of the Ca –P metabolism might impair the Ca/P ratio, such as hypophosphatemia (HypoP) not PHPT related. The aim of this study is to examine the diagnostic value of Ca/P ratio in the diagnosis of PHPT and HypoP not PHPT related.MethodsSingle-center, retrospective, case –control study, including 150 patients with PHPT and 306 patients with HypoP, compared with 150 controls. HypoP patients were enrolled among HIV-infected pati...
Source: Journal of Endocrinological Investigation - February 22, 2019 Category: Endocrinology Source Type: research

Differences in the cluster of depressive symptoms between subjects with type 2 diabetes and individuals with a major depressive disorder and without diabetes
AbstractBackgroundDepressive disorder encompasses a wide spectrum of somatic and psychological symptoms. It is not known whether there are differences regarding the cluster of depressive symptomatology between subjects with depression with and without T2DM.PurposeTo explore whether the cluster of depression that prevails among depressive subjects with T2DM differs from individuals with depression, but without T2DM.Methods87 T2DM patients with a pathological Beck Depression Inventory test (BDI) were compared with 50  age- and gender-matched individuals with a major depressive disorder. All 21 items expressed in the BDI...
Source: Journal of Endocrinological Investigation - February 20, 2019 Category: Endocrinology Source Type: research

Gut microbiome and microbial metabolites: a new system affecting metabolic disorders
ConclusionIn this review, I will summarize the current findings regarding the role of gut microbiome and metabolites in metabolic disorders to argue whether the current achievements may be translated into clinical practice. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 20, 2019 Category: Endocrinology Source Type: research

African statue with goiter
ConclusionThe statue reported seems to represent a case of real goiter. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 20, 2019 Category: Endocrinology Source Type: research

The representation of a goiter by Renaissance painter Moretto da Brescia
AbstractAlessandro Bonvicino (c. 1498 –1554), commonly known as Il Moretto da Brescia, was an Italian Renaissance painter. In his “The Adoration of Shepherds” (1539–1540), a shepherd shows a bi-lobar goiter. The painter was active in a geographical area, where inhabitants often suffered from endemic goiter due to dietary iodine deficiency and could have influenced Moretto. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 18, 2019 Category: Endocrinology Source Type: research

Effects of PCSK9 inhibitors on LDL cholesterol, cardiovascular morbidity and all-cause mortality: a systematic review and meta-analysis of randomized controlled trials
ConclusionsPCSK-9 inhibitors are effective in reducing LDL cholesterol and the incidence of major cardiovascular events in high-risk patients. Bococizumab does not show significant effects on MACE.Registration numberPROSPERO-CRD42018087640. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 14, 2019 Category: Endocrinology Source Type: research

Functional hypothalamic and drug-induced amenorrhea: an overview
AbstractBackgroundFunctional hypothalamic amenorrhea (FHA) is a form of chronic anovulation not due to identifiable organic causes and with adverse health consequences. The identification of women with this disorder or the precocious identification of women at risk is based on the knowledge of lifestyle risk factors or behaviors such as stress, weight loss, and excessive physical exercise that are known to negatively impact gonadal axis activity.Methods In this overview, we described the most common forms of FHA, in particular stress-induced amenorrhea and overtraining-induced amenorrhea. In addition, although its mechanis...
Source: Journal of Endocrinological Investigation - February 11, 2019 Category: Endocrinology Source Type: research

The clinical enigma of the “Flea catcher” by Georges de La Tour: a pregnant sinner with pre-eclampsia or a hypothyroid girl?
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 7, 2019 Category: Endocrinology Source Type: research

Can combination of glucocorticoids with other immunosoppressive drugs reduce the cumulative dose of glucocorticoids for moderate-to-severe and active Graves ’ orbitopathy?
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 4, 2019 Category: Endocrinology Source Type: research

Iodine supplementation in women of reproductive age: a survey of clinical practice among Italian gynecologists and midwives
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 2, 2019 Category: Endocrinology Source Type: research

Correction to: In memory of Professor Domenico Andreani
Unfortunately, the author name and his affiliation were published in the original publication. They have now been removed. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 2, 2019 Category: Endocrinology Source Type: research

Thyroid hormone resistance from newborns to adults: a Spanish experience
ConclusionsWe report the clinical and genetic characteristics of a Spanish RTH β cohort, from neonates to adults. We also describe one novel mutation in theTHRB gene as the cause of the disease. The simultaneous analysis of TSH and T4 carried out in the program for the screening of inborn errors of metabolism facilitates the early diagnosis of RTH β in newborns and has allowed us to estimate a minimum local incidence of RTH of 1/18,750 live newborns. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 1, 2019 Category: Endocrinology Source Type: research

Relationship between surrogate estimates and direct measurement of insulin resistance in women with polycystic ovary syndrome
Conclusion(s)The surrogate estimates of insulin resistance evaluated were significantly related to a direct measure of insulin resistance, and this was true of both the control population and women with PCOS. The magnitude of the relationship between the surrogate estimates and the direct measurement was comparable and not significantly altered by androgen levels. Fasting plasma insulin concentration seems to be at least as accurate as any other surrogate estimate, and is by far the simplest. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 30, 2019 Category: Endocrinology Source Type: research

Next-generation sequencing identifies novel mitochondrial variants in pituitary adenomas
ConclusionsNGS is a reliable method for investigating mitochondrial genome and heteroplasmy in pituitary adenomas. Out of the 496 detected variants, 414 have not been previously reported in pituitary adenoma. The high number of mtDNA variants may contribute to adenoma genesis, and some variants (i.e., T16189C) might associate with benign behaviour. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 25, 2019 Category: Endocrinology Source Type: research

Therapeutic effects of the selective farnesoid X receptor agonist obeticholic acid in a monocrotaline-induced pulmonary hypertension rat model
ConclusionsThe results of this study demonstrate a significant therapeutic effect of OCA in established MCT-induced PAH, improving exercise capacity associated with reduction of right ventricular hypertrophy and lung vascular remodeling. Thus, OCA dosing in a therapeutic protocol restores the balance between relaxant and contractile pathways in the lung, promoting cardiopulmonary protective actions in MCT-induced PAH. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 23, 2019 Category: Endocrinology Source Type: research

Alterations in the intestinal microbiota of patients with severe and active Graves ’ orbitopathy: a cross-sectional study
AbstractBackgroundThe intestinal microbiota was linked to autoimmune diseases. Graves ’ orbitopathy (GO) is an autoimmune disease that is usually associated with Graves’ disease. However, information on the microbiome of GO patients is yet lacking.ObjectivesTo investigate whether GO patients differ from healthy controls in the fecal microbiota.DesignA cross-sectional study.Setting33 patients with severe and active GO and 32 healthy controls of Han nationality were enrolled between March 2017 and March 2018.MethodsThe Gut microbial communities of the fecal samples of GO patients and healthy controls were analyze...
Source: Journal of Endocrinological Investigation - January 23, 2019 Category: Endocrinology Source Type: research

Epicardial adipose tissue is a predictor of decreased kidney function and coronary artery calcification in youth- and early adult onset type 2 diabetes mellitus
AbstractPurposeTo examine the association of epicardial and pericardial fat volume (EFV, PFV) with cardiovascular risk factors and kidney function in Native Americans of southwestern heritage with youth and early adult onset type 2 diabetes mellitus (T2DM) versus healthy controls.MethodsUsing computed tomography, we quantified EFV and PFV in 149 Native Americans (92 women, 57 men), 95 of which had T2DM (38 diagnosed prior to age 20  years). Duration of T2DM, mean carotid arterial mass (AM), coronary artery calcification (CAC), IL-6, and estimated glomerular filtration rate eGFRcr(CKD-EPI) were measured.ResultsEFV and ...
Source: Journal of Endocrinological Investigation - January 23, 2019 Category: Endocrinology Source Type: research

Gender difference in authorship of clinical practice guidelines and position statements in endocrinology
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 21, 2019 Category: Endocrinology Source Type: research

Bilateral inferior petrosal sinus sampling in adrenocorticotropin-dependent hypercortisolism: always, never, or sometimes?
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 11, 2019 Category: Endocrinology Source Type: research

Local ablative therapy of oligoprogressive TKI-treated thyroid cancer
AbstractMetastatic cancer patients generally respond well to treatment with tyrosine kinase inhibitors (TKIs). However, TKI resistance occurs in almost all cases and often leads to a change in treatment. Recent guidelines, including thyroid cancer, raised the possibility of locally treating TKI-resistant oligoprogressive disease, i.e., one or a few progressing lesions in an otherwise treatment-responsive metastatic cancer, thereby obviating the need to change the ongoing TKI. To determine the benefits of this intervention, we reviewed studies on the use of LAT for TKI-treated oligoprogressive cancers. We found that in non-...
Source: Journal of Endocrinological Investigation - January 9, 2019 Category: Endocrinology Source Type: research

A lute player peasant with nodular goiter by Bartolomeo Passarotti (1529 –1592)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 9, 2019 Category: Endocrinology Source Type: research

Hypothalamic –pituitary–adrenal axis function in traumatic spinal cord injury-related neuropathic pain: a case–control study
ConclusionsThis study demonstrated that, in chronic SCI patients with NP, basal cortisol levels are relatively higher compared to healthy controls, and that HPA axis can be activated with low- and standard-dose ACTH stimulation tests. Although NP following SCI was not significantly associated with hypo- or hypercortisolemia, either after low- or standard-dose ACTH stimulation test, the severity of NP during chronic SCI may be positively associated with HPA axis activity. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 9, 2019 Category: Endocrinology Source Type: research

The Mediterranean diet of an Italian worker of the sixteenth century portrayed by Annibale Carracci (1560 –1609)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 8, 2019 Category: Endocrinology Source Type: research

Mystical marriage of Saint Catherine by Paolo Veronese (1528 –1588)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 5, 2019 Category: Endocrinology Source Type: research

Guido Menzinger di Preussenthal (1934 –2018)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 4, 2019 Category: Endocrinology Source Type: research

Association of SOD2 A16V and PON2 S311C polymorphisms with polycystic ovary syndrome in Chinese women
ConclusionTheSOD2 A16V, but notPON2 S311C, polymorphism may be one of the genetic determinants for PCOS in Chinese women. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 3, 2019 Category: Endocrinology Source Type: research

In memory of Professor Domenico Andreani
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 2, 2019 Category: Endocrinology Source Type: research

Comparative study of testosterone and vitamin D analogue, elocalcitol, on insulin-controlled signal transduction pathway regulation in human skeletal muscle cells
ConclusionsAll together, our evidence indicates that whether both T and elo are able to affect upstream I-like pathway, they differently determine downstream effects in I-dependent cascade, suggesting diverse physiological roles in mediating I-like response in human skeletal muscle. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 1, 2019 Category: Endocrinology Source Type: research

Parathyroid scintigraphy in primary hyperparathyroidism: comparison between double-phase and subtraction techniques and possible affecting factors
ConclusionsDouble-phase scintigraphy has been more accurate than digital subtraction. The presence of thyroid disease could be a possible limit, affecting the subtraction more than the double-phase technique. Clinical data did not influence the scintigraphic outcome. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 1, 2019 Category: Endocrinology Source Type: research

Correction to: Cadmium exposure alters steroid receptors and proinflammatory cytokine levels in endothelial cells in vitro: a potential mechanism of endocrine disruptor atherogenic effect
Unfortunately, the figure captions 4 and 6 were incorrectly published in the original publication. The complete correct captions are given below. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 19, 2018 Category: Endocrinology Source Type: research

Thanks to Reviewers 2018
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 18, 2018 Category: Endocrinology Source Type: research

Sitagliptin vs. pioglitazone as add-on treatments in patients with uncontrolled type 2 diabetes on the maximal dose of metformin plus sulfonylurea
AbstractAimsTo compare the efficacy of sitagliptin versus pioglitazone as add-on drugs in patients with poorly controlled diabetes with metformin and sulfonylureas.MethodsThis is a randomized, open-label, parallel assignment clinical trial. Patients who had inadequate glycemic control [7% (53  mmol/mol) ≤ A1C 
Source: Journal of Endocrinological Investigation - December 10, 2018 Category: Endocrinology Source Type: research

The MAGI2 gene polymorphism rs2160322 is associated with Graves ’ disease but not with Hashimoto’s thyroiditis
ConclusionsOur study identified thatMAGI2 rs2160322 was strongly associated with GD susceptibility. The potential dysfunction of tight junction proteins and aberrant epithelial barrier caused by abnormalMAGI2 expression may be a novel mechanism of GD. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 8, 2018 Category: Endocrinology Source Type: research

Bone turnover markers, BMD and TBS after short-term, high-dose glucocorticoid therapy in patients with Graves ’ orbitopathy: a small prospective pilot study
AbstractPurposeChronic GC administration has numerous side effects, but little is known about the side effects of their short-term use (
Source: Journal of Endocrinological Investigation - December 5, 2018 Category: Endocrinology Source Type: research

Incidence of Y chromosome microdeletions in patients with Klinefelter syndrome
ConclusionThe percentage of microdeletions in KS patients was lower than in NOA patients, suggesting that AZF microdeletions and KS do not have a causal relationship and that Y chromosome microdeletions are not a genetic factor linked to KS. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 29, 2018 Category: Endocrinology Source Type: research

GSTP1 gene methylation and AHR rs2066853 variant predict resistance to first generation somatostatin analogs in patients with acromegaly
ConclusionsIn acromegaly,GSTP1 gene methylation associates with resistance to SSA treatment, especially in patients carrying also theAHR rs2066853 variant, and with increased prevalence of colonic polyps and diabetes mellitus. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 28, 2018 Category: Endocrinology Source Type: research

Cadmium exposure alters steroid receptors and proinflammatory cytokine levels in endothelial cells in vitro: a potential mechanism of endocrine disruptor atherogenic effect
ConclusionIn conclusion, our study demonstrates for the first time that Cd alters sex-steroid hormone receptors level and activity likely affecting intracellular signaling linked to a proinflammatory state in endothelial cells. This alteration might possibly lead to endothelial cell injury and vascular dysfunction and could be a mechanism of gender-specific atherogenic damages induced by endocrine disruptors and, thus, induce atherogenic events with increased risk of cardiovascular diseases in individuals exposed to this endocrine disruptor. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 26, 2018 Category: Endocrinology Source Type: research

Periostin concentrations in childhood-onset craniopharyngioma patients
ConclusionsIn CP, periostin concentrations are not associated with known risk factors for NAFLD such as hepatic and metabolic parameters, obesity and hypothalamic lesions. Accordingly, periostin does not seem to be a suitable marker for NAFLD in CP. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 24, 2018 Category: Endocrinology Source Type: research

Endocrine and metabolic adverse effects of immune checkpoint inhibitors: an overview (what endocrinologists should know)
AbstractImmune checkpoint inhibitors (ICIs) are novel anticancer agents, recently introduced with the aim of boosting the immune response against tumors. ICIs are monoclonal autoantibodies that specifically target inhibitory receptors on T cells: cytotoxic T lymphocyte antigen 4 (CTLA4), programmed death 1 (PD-1) and its ligand (PD-1L). ICIs also generate peculiar dysimmune toxicities, called immune-related adverse events (irAEs), that can potentially affect any tissue, and some may be life-threatening if not promptly recognized. The endocrine and metabolic side effects of ICIs are reviewed here, with a particular focus on...
Source: Journal of Endocrinological Investigation - November 23, 2018 Category: Endocrinology Source Type: research

Type 2 diabetes treatment and progression of chronic kidney disease in Italian family practice
ConclusionIn the setting of Italian family practice, sulfonylurea use is associated with progressive CKD in patients with T2DM. Metformin, at doses progressively reduced according to CKD stages, as recommended by guidelines, is not associated with fast progression. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 21, 2018 Category: Endocrinology Source Type: research

Association of serum ghrelin with weight gain during pregnancy in overweight and normal women
ConclusionsOur results indicate that the increased level of serum ghrelin could not be considered as a key mediator for weight gain difference during pregnancy of overweight women. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 21, 2018 Category: Endocrinology Source Type: research