Safety and efficacy of common vitamin D supplementation in primary hyperparathyroidism and coexistent vitamin D deficiency and insufficiency: a systematic review and meta-analysis
ConclusionVitamin D supplementation in patients with PHPT and vitamin D deficiency significantly reduces PTH and ALP levels without causing hypercalcemia and hypercalciuria. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 16, 2021 Category: Endocrinology Source Type: research

Cell adhesion molecule L1 like plays a role in the pathogenesis of idiopathic hypogonadotropic hypogonadism
ConclusionsOur study reports the genetic relevance ofCHL1 in IHH, and characterizes the phenotypic and therapeutic profiles in patients carrying theCHL1 RSV.CHL1 may act as a new IHH-associated gene, and should be taken into consideration in future investigations for this field. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 16, 2021 Category: Endocrinology Source Type: research

Primary aldosteronism: considerations about the evaluation of the aldosterone to renin ratio during canrenone treatment
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 16, 2021 Category: Endocrinology Source Type: research

Remission in Cushing ’s disease is predicted by cortisol burden and its withdrawal following pituitary surgery
AbstractAimTo ascertain the predictors of remission and relapse in patients of Cushing ’s disease (CD) undergoing pituitary transsphenoidal surgery (TSS).MethodsPatients with CD subjected to TSS over 35  years at a tertiary care center were included. Patients were grouped into remission and persistent disease at 1 year after surgery, and were further followed up for relapse. Demographic, clinical, biochemical, histological, radiological and post-operative follow-up parameters were analyzed.ResultsOf the 152 patients of CD, 145 underwent TSS. Remission was achieved in 95 (65.5%) patients at 1  year. Pat...
Source: Journal of Endocrinological Investigation - January 16, 2021 Category: Endocrinology Source Type: research

Assessment of children in the autistic spectrum disorder that carry the T hr 92A la -DIO2 polymorphism
ConclusionThe MAF is not different in ASD children, but carriers of the Thr92Ala-DIO2 polymorphism exhibited higher adaptive behavior. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 15, 2021 Category: Endocrinology Source Type: research

Prevalence of hepatic steatosis in patients with type 2 diabetes and response to glucose-lowering treatments. A multicenter retrospective study in Italian specialist care
AbstractAimType 2 diabetes (T2D) is a risk factor for metabolic dysfunction-associated fatty liver disease (MAFLD), which is becoming the commonest cause of chronic liver disease worldwide. We estimated MAFLD prevalence among patients with T2D using the hepatic steatosis index (HSI) and validated it against liver ultrasound. We also examined whether glucose-lowering medications (GLM) beneficially affected HSI.MethodsWe collected data from 46 diabetes clinics (n = 281,381 T2D patients), extracted data to calculate HSI and validated it against ultrasound-detected hepatic steatosis. We then examined changes in H...
Source: Journal of Endocrinological Investigation - January 11, 2021 Category: Endocrinology Source Type: research

Lipocalin-2: a role in hepatic gluconeogenesis via AMP-activated protein kinase (AMPK)
ConclusionThe present study demonstrates that LCN2 regulates insulin sensitivity and glucose metabolism through inhibiting AMPK activity, and regulating FoxO1 and its downstream genes PEPCK/G6P, which regulate hepatic gluconeogenesis. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 9, 2021 Category: Endocrinology Source Type: research

Assessment of non-traumatic vertebral fractures in Cushing ’s syndrome patients
AbstractPurposeHypercortisolism has detrimental effects on bone metabolism with the consequences of bone loss and bone fractures. We aimed to evaluate the frequency of vertebral fragility fractures and to determine the factors associated with Cushing ’s syndrome (CS).MethodsA total of 135 patients diagnosed with Cushing ’s syndrome [108 patients with Cushing’s disease and 27 patients with adrenocortical adenoma] and 107 healthy controls were included in this cross-sectional study. The available clinical, laboratory, and radiologic data of patients with CS were recorded, retrospectively. Lateral vertebral ...
Source: Journal of Endocrinological Investigation - January 9, 2021 Category: Endocrinology Source Type: research

The syndrome of Toulouse-Lautrec
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 9, 2021 Category: Endocrinology Source Type: research

Why diabetes outpatient clinics should not close during pandemic crises
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 4, 2021 Category: Endocrinology Source Type: research

Hidden hypercortisolism: a too frequently neglected clinical condition
ConclusionThese data indicate that patients with resistant or suddenly worsening hypertension or DM2 or unexplainable bone fragility should be screened for HidHyCo using the most recently approved sensitive cut-offs. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 4, 2021 Category: Endocrinology Source Type: research

Sestamibi Single-Positron Emission Computed Tomography/Diagnostic-quality Computed Tomography for the localization of abnormal parathyroid glands in patients with primary hyperparathyroidism: What clinicopathologic factors affect its accuracy?
ConclusionMGD was most strongly associated with discordance between MIBI-SPECT/CT and intraoperative findings followed by a PTH level higher than 192.5  pg/mL and parathyroid lesion size of 12 mm or less. Surgeons should recognize these potential limitations, which may improve the preoperative procedure by encouraging further localization imaging and promptly facilitate intraoperative troubleshooting. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 3, 2021 Category: Endocrinology Source Type: research

Comics ’ representation of Graves’ orbitopathy, by Emil Ferris
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 3, 2021 Category: Endocrinology Source Type: research

Comparing the bone mineral density among male patients with latent autoimmune diabetes and classical type 1 and type 2 diabetes, and exploring risk factors for osteoporosis
ConclusionsCompared with male patients with T2DM, lower BMDs were observed in patients with LADA and T1DM. Low BMI, uric acid, C-peptide levels, and high osteocalcin levels are risk factors for developing low BMD in male patients with diabetes. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 2, 2021 Category: Endocrinology Source Type: research

Was Tiepolo ’s wife affected by Graves' disease?
AbstractTiepolo (1696 –1770) was an Italian Rococo painter and printmaker, and is now considered to be one of the most important members of the 18th-century Venetian school. The muse that lent her face to Cleopatra and inspired many Tiepolo’s works was his beloved wife, Maria Cecilia Guardi. Because of her appearanc e, we cannot rule out that she suffered from Graves' disease, an autoimmune condition that is characterized by goiter, exophthalmos and restlessness. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 2, 2021 Category: Endocrinology Source Type: research

Gut microbiota alterations reveal potential gut –brain axis changes in polycystic ovary syndrome
ConclusionsGABA-producing bacteria that were increased in PCOS, includingParabacteroides distasonis,Bacteroides fragilis andEscherichia coli, showed positive relationship with serum LH levels and LH:FSH ratios. In conclusion, gut microbial dysbiosis in women with PCOS is associated with neuroendocrine changes, revealing a potential gut –brain axis in PCOS. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 2, 2021 Category: Endocrinology Source Type: research

DPP4 gene silencing inhibits proliferation and epithelial-mesenchymal transition of papillary thyroid carcinoma cells through suppression of the MAPK pathway
ConclusionCollectively, the present study demonstrated that DPP4 gene silencing inhibits PTC cell proliferation and EMT and promotes cell apoptosis via suppression of the MAPK pathway, thus highlighting a possible regulatory pathway in PTC progression. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 2, 2021 Category: Endocrinology Source Type: research

Management and outcome of metastatic pheochromocytomas/paragangliomas: an overview
ConclusionsThe choice of the appropriate treatment should be based on multidisciplinary and personalized approach taking into account the rarity and the variability of these tumors. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 1, 2021 Category: Endocrinology Source Type: research

Body composition and microvascular damage in systemic sclerosis patients
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 1, 2021 Category: Endocrinology Source Type: research

A young lady with goiter by Mario Sironi (1885 –1961)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 1, 2021 Category: Endocrinology Source Type: research

Reply to letter to the editor: “COVID‐19 and the endocrine system: exploring the unexplored”. Focus on acromegaly
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 1, 2021 Category: Endocrinology Source Type: research

Baseline serum TSH levels predict the absence of thyroid dysfunction in cancer patients treated with immunotherapy
ConclusionsPre-treatment serum TSH and ATAbs levels may help to identify patients at high risk for primary thyroid dysfunction. Our study suggests guidance for an appropriate timely screening and for a tailored management of thyroid dysfunctions in patients treated with ICIs. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 26, 2020 Category: Endocrinology Source Type: research

Tele-medicine versus face-to-face consultation in Endocrine Outpatients Clinic during COVID-19 outbreak: a single-center experience during the lockdown period
AbstractContextThe COVID-19 outbreak in Italy is the major concern of Public Health in 2020: measures of containment were progressively expanded, limiting Outpatients ’ visit.ObjectiveWe have developed and applied an emergency plan, tailored for Outpatients with endocrine diseases.DesignCross-sectional study from March to May 2020.SettingReferral University-Hospital center.Patients1262 patients in 8  weeks.InterventionsThe emergency plan is based upon the endocrine triage, the stay-safe procedures and the tele-Endo. During endocrine triage every patient was contacted by phone to assess health status and define i...
Source: Journal of Endocrinological Investigation - December 23, 2020 Category: Endocrinology Source Type: research

Change in newly diagnosed Graves ’ disease phenotype between the twentieth and the twenty-first centuries: meta-analysis and meta-regression
AbstractPurposeAccording to a few recent studies, the clinical phenotype of Graves ’ disease (GD) at onset is becoming milder in recent years, in terms of prevalence and severity of hyperthyroidism, goiter and overt eye disease. The aim of this study was to assess the change in GD phenotype across the late twentieth and the early twenty-first centuries.Materials and methodsWe carried out a systematic search of studies published between 1/1/1980 and 12/31/2017 describing na ïve GD patients at diagnosis. We collected epidemiological, clinical, biochemical and serological data reported in the selected studies, and ...
Source: Journal of Endocrinological Investigation - December 21, 2020 Category: Endocrinology Source Type: research

An update on the pathogenesis of Hashimoto ’s thyroiditis
AbstractIt is 70  years since Noel Rose embarked on his pioneering studies that lead to the discovery of autoimmune thyroiditis and the elucidation of Hashimoto’s thyroiditis. This short review to honour his passing focuses on the developments in our understanding of the causes and pathogenesis of HT over the las t five years. Recent genetic studies have reported heritability estimates for HT and associated diseases for the first time, and emphasised the complexity of the genetic factors involved, including monogenic forms of HT. Environmental factors continue to be elucidated, especially as a side effect of dru...
Source: Journal of Endocrinological Investigation - December 17, 2020 Category: Endocrinology Source Type: research

An update on non-thyroidal illness syndrome
AbstractThe non-thyroidal illness syndrome (NTIS) was first reported in the 1970s as a remarkable ensemble of changes in serum TH (TH) concentrations occurring in probably any severe illness. Ever since, NTIS has remained an intriguing phenomenon not only because of the robustness of the decrease in serum triiodothyronine (T3), but also by its clear correlation with morbidity and mortality. In recent years, it has become clear that (parenteral) feeding in patients with critical illness should be taken into account as a major determinant not only of NTIS but also of clinical outcome. Moreover, both experimental animal and c...
Source: Journal of Endocrinological Investigation - December 15, 2020 Category: Endocrinology Source Type: research

The new generation PFAS C6O4 does not produce adverse effects on thyroid cells in vitro
ConclusionsThe present in vitro study constitutes the first evaluation of the potential adverse effects of the new emerging PFAS C6O4 in cultured rat and human thyroid cells, suggesting its safety for thyroid cells in vitro. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 14, 2020 Category: Endocrinology Source Type: research

Increased prevalence of impulse control disorder symptoms in endocrine diseases treated with dopamine agonists: a cross-sectional study
AbstractIntroductionImpulse control disorders (ICDs) have been described as a side effect of dopamine agonists (DAs) in neurological as well as endocrine conditions. Few studies have evaluated the neuropsychological effect of DAs in hyperprolactinemic patients, and these have reported a relationship between DAs and ICDs. Our objective was to screen for ICD symptoms in individuals with DA-treated endocrine conditions.Materials and methodsA cross-sectional analysis was conducted on 132 patients with pituitary disorders treated with DAs (DA exposed), as well as 58 patients with pituitary disorders and no history of DA exposur...
Source: Journal of Endocrinological Investigation - December 12, 2020 Category: Endocrinology Source Type: research

Putative protective role of autoantibodies against the insulin-like growth factor-1 receptor in Graves ’ Disease: results of a pilot study
AbstractBackgroundThe insulin-like growth factor-1 receptor (IGF-1R) is a key element in the pathogenesis of Graves ’ Orbitopathy (GO), but the role of IGF-1R autoantibodies (IGF-1RAbs) has not been established.MethodsWe designed a cross-sectional investigation to measure IGF-1RAbs in patients with Graves ’ disease (GD), with or without GO, who underwent radioiodine therapy followed by glucocorticoids (GC). Twenty-nine patients were included, 15 of which with GO. Patients were evaluated at baseline and three and 6 months after radioiodine. The primary objective was the prevalence of positive tests for IGF-...
Source: Journal of Endocrinological Investigation - November 9, 2020 Category: Endocrinology Source Type: research

Weight loss effect of liraglutide in real-life: the experience of a single Italian obesity center
ConclusionL treatment of OO in a real life setting yielded results comparable to those reported by the major RCCTs. Combining the results of RCCTs with the observations from real life may increase their power and overcome their respective limitations. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 9, 2020 Category: Endocrinology Source Type: research

Testosterone treatment in male patients with Klinefelter syndrome: a systematic review and meta-analysis
ConclusionTRT outcomes observed in KS regarding BMD, body composition and glyco-metabolic control, are similar to those observed in male with hypogonadism not related to KS. Moreover, body composition and BMD are better in treated than untreated hypogonadal KS. Larger and longer randomized placebo-controlled trials are advisable to better confirm the present data, mainly derived from observational studies. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 9, 2020 Category: Endocrinology Source Type: research

Asymmetry indicates more severe and active disease in Graves ’ orbitopathy: results from a prospective cross-sectional multicentre study
AbstractPurposePatients with Graves ’ orbitopathy can present with asymmetric disease. The aim of this study was to identify clinical characteristics that distinguish asymmetric from unilateral and symmetric Graves’ orbitopathy.MethodsThis was a multi-centre study of new referrals to 13 European Group on Graves ’ Orbitopathy (EUGOGO) tertiary centres. New patients presenting over a 4 month period with a diagnosis of Graves’ orbitopathy were included. Patient demographics were collected and a clinical examination was performed based on a previously published protocol. Patients were categorized a...
Source: Journal of Endocrinological Investigation - November 9, 2020 Category: Endocrinology Source Type: research

Management of cN0 papillary thyroid microcarcinoma patients according to risk-scoring model for central lymph node metastasis and predictors of recurrence
AbstractBackgroundThe role of routine prophylactic central neck dissection (pCND) in clinically lymph node-negative (cN0) papillary thyroid microcarcinoma (PTMC) patients remains controversial. This retrospective study aimed to identify the clinical and pathologic factors of central lymph node metastasis (CLNM) and recurrence in PTMC patients.MethodsA total of 371 cN0 PTMC patients from two hospitals were retrospectively analyzed. All patients underwent thyroidectomy plus pCND between January 2010 and January 2018. Clinicopathological features were collected, univariate and multivariate analyses were performed to determine...
Source: Journal of Endocrinological Investigation - November 9, 2020 Category: Endocrinology Source Type: research

Climate and air pollution exposure are associated with thyroid function parameters: a retrospective cross-sectional study
AbstractObjectivesThere are still controversies about the impact of climatic and environmental factors on thyroid function parameters in healthy populations. We investigated the relationships between climate, air pollution exposure, and thyroid function fluctuations.MethodsWe retrospectively reviewed 327,913 individuals attending routine health checks from December 2013 to December 2018. We analyzed the associations between thyroid function and climatic factors using Spearman ’s correlation analysis. We explored the relationships between thyroid function and air pollution exposure using multiple linear regression ana...
Source: Journal of Endocrinological Investigation - November 7, 2020 Category: Endocrinology Source Type: research

Thyroid nodules in xeroderma pigmentosum patients: a feature of premature aging
ConclusionsXP patients have an increased incidence of thyroid nodules at an early age in comparison to the general population. These finding confirm another premature aging feature of XP. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 5, 2020 Category: Endocrinology Source Type: research

Dysmetabolic adipose tissue in obesity: morphological and functional characteristics of adipose stem cells and mature adipocytes in healthy and unhealthy obese subjects
AbstractThe way by which subcutaneous adipose tissue (SAT) expands and undergoes remodeling by storing excess lipids through expansion of adipocytes (hypertrophy) or recruitment of new precursor cells (hyperplasia) impacts the risk of developing cardiometabolic and respiratory diseases. In unhealthy obese subjects, insulin resistance, type 2 diabetes, hypertension, and obstructive sleep apnoea are typically associated with pathologic SAT remodeling characterized by adipocyte hypertrophy, as well as  chronic inflammation, hypoxia, increased visceral adipose tissue (VAT), and fatty liver. In contrast, metabolically heal...
Source: Journal of Endocrinological Investigation - November 3, 2020 Category: Endocrinology Source Type: research

Thyroid hormone concentrations in severely or critically ill patients with COVID-19
ConclusionFT3 concentration was significantly lower in patients with severe COVID-19 than in non-severely ill patients. Reduced FT3 independently predicted all-cause mortality of patients with severe COVID-19. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 2, 2020 Category: Endocrinology Source Type: research

Management of premature ejaculation: a clinical guideline from the Italian Society of Andrology and Sexual Medicine (SIAMS)
AbstractPremature ejaculation (PE) is the most prevalent male sexual dysfunction, and the most recently defined. PE is often mistakenly considered a purely psychosexological symptom by patients: the lacking awareness in regards to the pathophysiology and treatments often lead to resignation from the patients ’ side, making PE the most underdiagnosed sexual complaint. However, an ever-growing body of evidence supporting several organic factors has been developed in the last decades and several definitions have been suggested to encompass all defining features of PE. In the present document by the Itali an Society of A...
Source: Journal of Endocrinological Investigation - October 30, 2020 Category: Endocrinology Source Type: research

The hypothalamic –pituitary–adrenal and -thyroid axes activation lasting one year after an earthquake swarm: results from a big data analysis
AbstractPurposeTo cope physical and/or psychological threats, the human body activates multiple processes, mediated by a close interconnection among brain, endocrine and inflammatory systems. The aim of the study was to assess the hypothalamic –pituitary–adrenal (HPA) and hypothalamic–pituitary–thyroid (HPT) axes involvement after an acute stressful event (Emilia Romagna earthquake swarm) with a big data approach.MethodsA retrospective, observational trial was performed, collecting all biochemical examinations regarding HPA and HPT axes performed in the same laboratory the year before and the year a...
Source: Journal of Endocrinological Investigation - October 29, 2020 Category: Endocrinology Source Type: research

Tissue and circulating microRNAs as biomarkers of response to obesity treatment strategies
ConclusionsAlthough further research is needed to draw firm conclusions, there is increasing evidence about microRNAs as potential biomarkers for weight loss and response to intervention strategies in obesity. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 28, 2020 Category: Endocrinology Source Type: research

Levothyroxine and insulin requirement in autoimmune polyglandular type 3 syndrome: a real-life study
AbstractPurposeTo evaluate factors influencing the insulin and levothyroxine requirement in patients with autoimmune polyglandular syndrome type 3 (APS-3) vs. patients with type 1 diabetes mellitus (T1DM) and autoimmune hypothyroidism (AH) alone, respectively.MethodsFifty patients with APS-3, 60 patients with T1DM and 40 patients with AH were included. Anthropometric, clinical and biochemical parameters were evaluated in all patients. Insulin requirement was calculated in patients with APS-3 and T1DM, while levothyroxine requirement was calculated in APS-3 and AH.ResultsPatients with APS-3 showed higher age (p =&thi...
Source: Journal of Endocrinological Investigation - October 24, 2020 Category: Endocrinology Source Type: research

Stimulated GH levels during the transition phase in Prader –Willi syndrome
ConclusionOur study shows that about 20% of patients with PWS fulfilled the criteria for GHD during the transitional age, suggesting the need of an integrated analysis of GH/IGF-I axis, in the context of the general clinical picture and other endocrine abnormalities, in all subjects after attainment of final stature. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 23, 2020 Category: Endocrinology Source Type: research

Efficacy of parathyroidectomy compared with active surveillance in patients with mild asymptomatic primary hyperparathyroidism: a systematic review and meta-analysis of randomized-controlled studies
ConclusionsIn patients with mild asymptomatic PHPT, PTx increases BMD and reduces serum calcium concentrations. However, its superiority over active surveillance in terms of fracture risk, nephrolithiasis and QoL cannot be supported by current data. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 19, 2020 Category: Endocrinology Source Type: research

Angiopoietin-like 8 (ANGPTL8) as a potential predictor of NAFLD in paediatric patients with Prader-Willi Syndrome
AbstractPurposeAngiopoietin-like 8 (ANGPTL8) is a liver- and adipose tissue-produced protein that predicts non-alcoholic fatty liver disease (NAFLD) and altered metabolic homeostasis in the general population as well as in persons with common and genetic obesity, including the Prader –Willi syndrome (PWS). However, its metabolic correlate in paediatric patients with respect to PWS is unknown.MethodsThis cross-sectional study investigated circulating ANGPTL8 and adipocytokines levels in 28 PWS and 28 age-, sex- and BMI-matched children and adolescents (age, 7.0 –17.8y) in relation to NAFLD and metabolic homeosta...
Source: Journal of Endocrinological Investigation - October 16, 2020 Category: Endocrinology Source Type: research

TSH lowering effects of metformin: a possible mechanism of action
AbstractPreliminary clinical evidence suggests that metformin has TSH lowering effects in patients with T2DM and hypothyroidism or in those with TSH serum levels in the upper normal value. Also, metformin may exert a protective role against thyroid nodules growth in patients without insulin-resistance. The cross-talk between tyrosine kinase receptors and the G protein-coupled receptors (which the TSHR belongs to) has been already shown and IRS1 may represent the hub link between TSHR and IR pathways. By influencing IRS1 phosphorylation pattern, metformin may sensitize TSHR to TSH, thus explaining the findings of clinical s...
Source: Journal of Endocrinological Investigation - October 14, 2020 Category: Endocrinology Source Type: research

Decreased Sestrin levels in patients with type 2 diabetes and dyslipidemia and their association with the severity of atherogenic index
ConclusionWe report for the first time that Sestrins levels are significantly decreased in diabetes and dyslipidemic conditions. More strikingly, Sestrin2 had a strong association with atherogenic risk factors and severity of atherogenic index and we suggest that Sestrin2 may be used as a biomarker for assessing atherogenesis. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 13, 2020 Category: Endocrinology Source Type: research

The role of immune checkpoint inhibitor therapy in advanced adrenocortical carcinoma revisited: review of literature
ConclusionICI, mainly pembrolizumab, is a potential therapeutic option, which is safe and associated with prolonged OS benefit, in selected patients with advanced ACC. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 12, 2020 Category: Endocrinology Source Type: research

Global iodine nutrition 2020: Italy is an iodine sufficient country
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 12, 2020 Category: Endocrinology Source Type: research

The informative experience of endocrine residents with COVID-19
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 12, 2020 Category: Endocrinology Source Type: research

Is it possible to predict the development of diabetes insipidus after pituitary surgery? Study of 241 endoscopic transsphenoidal pituitary surgeries
ConclusionIn patients with PAs younger than 65  years, in whom diaphragm has been opened during pituitary surgery and/or with a total tumor resection, special hydric balance monitoring should be maintained in the postoperative period due to the increased risk of developing DI. The risk of permanent DI increases as PA craniocaudal diameter incre ased. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 11, 2020 Category: Endocrinology Source Type: research