Leptin, ghrelin, nesfatin-1, and orexin-A plasma levels in girls with premature thelarche
ConclusionThese results suggest that in addition to serum leptin levels, serum orexin-A and nesaftin-1 can take part in the initiation of PT. Few studies have investigated the relationship between nesfatin-1 and orexin-A levels and age at onset of puberty; hence, it should be a subject for future studies. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 1, 2022 Category: Endocrinology Source Type: research

Sirolimus as a second-line treatment for Graves ’ orbitopathy
ConclusionsSirolimus seems to be an effective second-line treatment for GO. Further randomized clinical trials are needed to confirm our observations. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 1, 2022 Category: Endocrinology Source Type: research

Vitamin D and interferon- γ co-operate to increase the ACE-2 receptor expression in primary cultures of human thyroid cells
ConclusionsVitD would defend the body by SARS-COV2 both by regulating the host immune defense and by up-regulating of the expression of the ACE-2 receptor. The existence of a co-operation between VitD and IFN- γ demonstrated in other systems is supported also for ACE-2 up-regulation. These observations lead to an increased interest for the potential therapeutic benefits of VitD supplementation in COVID-19. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 1, 2022 Category: Endocrinology Source Type: research

Vitamin D status and parathyroid hormone assessment in girls with central precocious puberty
ConclusionVitamin D status in 6- to 8-year-old girls with CPP is similar to that in prepubertal girls. PTH concentrations were significantly higher in girls with CPP, and this could be considered as a physiological characteristic of puberty and, in this case, of pubertal precocity. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 1, 2022 Category: Endocrinology Source Type: research

Nodular goiter and laryngeal anatomic variant in two portraits of the hellenistic dramatist Menander
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 1, 2022 Category: Endocrinology Source Type: research

A further example of Christ with gynecomastia
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 1, 2022 Category: Endocrinology Source Type: research

Artificial intelligence-based radiomics on computed tomography of lumbar spine in subjects with fragility vertebral fractures
ConclusionsArtificial intelligence-based analyses on spine CT images identified RFs associated with fragility VFs. Future studies are needed to test the predictive value of RFs on opportunistic CT scans in identifying subjects with primary and secondary osteoporosis at high risk of fracture. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 10, 2022 Category: Endocrinology Source Type: research

Graves ’ disease induced by Alemtuzumab in relapsing–remitting multiple sclerosis patients: an observational study in a reference center
ConclusionGD-IA has an atypical course compared to classical forms of the disease. The identification of risk factors for the development of the disease before starting treatment with Alemtuzumab and early monitoring of thyroid function once this treatment is initiated prove to be useful strategies in the diagnosis and clinical management of this condition. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 10, 2022 Category: Endocrinology Source Type: research

Noncompliance to iodine supplementation recommendation is a risk factor for iodine insufficiency in Portuguese pregnant women: results from the IoMum cohort
ConclusionsA low compliance to iodine supplementation recommendation in pregnancy accounted for a mild-to-moderately iodine deficiency. Our results evidence the need to support iodine supplementation among pregnant women in countries with low household coverage of iodised salt.Trial registration number NCT04010708, registered on the 8th July 2019. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 10, 2022 Category: Endocrinology Source Type: research

The impact of male factors and their correct and early diagnosis in the infertile couple's pathway: 2021 perspectives
ConclusionTo provide a high-level of care, the andrologist must face several critical diagnostical and therapeutical steps. Even though ART may be the final and decisive stage of this decisional network, neglecting to treat the male partner may ultimately increase the risks of negative outcome, as well as costs and psychological burden for the couple itself. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 10, 2022 Category: Endocrinology Source Type: research

Serum calcium levels are associated with cognitive function in hypoparathyroidism: a neuropsychological and biochemical study in an Italian cohort of patients with chronic post-surgical hypoparathyroidism
ConclusionsPatients with chronic PS-HypoPT in conventional therapy do not show a severe cognitive impairment; however, cognitive functions namely visuo-spatial attention, executive function and semantic memory appear to be modulated by Alb-Ca and impaired by its low levels. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 10, 2022 Category: Endocrinology Source Type: research

Questionnaire and tools: clinical powerful instrument in acromegaly diagnosis and management
ConclusionQuestionnaires and tools are useful in the management of acromegaly patients. They help clinicians evaluate patients ’ symptoms and could assist in the evaluation of disease activity. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 10, 2022 Category: Endocrinology Source Type: research

Body composition and obstructive sleep apnoea assessment in adult patients with Prader –Willi syndrome: a case control study
ConclusionsThis study confirmed that AHI and ODI indices were worse in PWS than in age, sex and BMI-matched controls. The lack of their significant association with the anthropometric parameters and FM supported the existence of PWS-related mechanisms in OSAS pathophysiology that are independent of visceral obesity and FM. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 10, 2022 Category: Endocrinology Source Type: research

Psychological stress, emotions, and quality of life in men and women with congenital adrenal hyperplasia
ConclusionWomen with congenital adrenal hyperplasia have higher perceived distress, tension-anxiety, depression dejection, fatigue-inertia, and worse environmental aspect of quality of life than age-matched control women, while perceived psychological stress, emotional state and quality of life in men with congenital adrenal hyperplasia do not differ from that of age-matched control men. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 10, 2022 Category: Endocrinology Source Type: research

Tumour size in adrenal tumours: its importance in the indication of adrenalectomy and in  surgical outcomes—a single-centre experience
ConclusionRisk of malignancy and of pheochromocytoma increased as tumour size increased, but, in the presurgical estimation of malignancy risk and of pheochromocytoma, not only tumour size, also lipidic content and other radiological features, should be considered. The risk of complications was independent of tumour size, but hospital stay was longer in patients with complication or open approach. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 10, 2022 Category: Endocrinology Source Type: research