Effects of growth hormone on pregnancy rates of patients with thin endometrium
AbstractPurposeTo investigate whether growth hormone (GH) could improve pregnancy rates of patients with thin endometrium by clinical study and laboratory experiments.Materials and methodsNinety-three patients were randomized to either the GH-received group (40) or the routine exogenous administration of estrogens control group (53) for clinical study. The human endometrial carcinoma cell line RL95-2 was used for testing the role of GH with Western blot and real-time PCR by exposure to various concentrations of GH (0.1 nM,1 nM,10 nM,100 nM).ResultsPatients treated with GH had a significantly (P 
Source: Journal of Endocrinological Investigation - April 18, 2018 Category: Endocrinology Source Type: research

Lack of association between obesity and aggressiveness of differentiated thyroid cancer
ConclusionsObesity was not associated with aggressive features in this prospective, European cohort of patients with DTC. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 17, 2018 Category: Endocrinology Source Type: research

Adrenocortical carcinoma: the dawn of a new era of genomic and molecular biology analysis
AbstractOver the last decade, the development of novel and high penetrance genomic approaches to analyze biological samples has provided very new insights in the comprehension of the molecular biology and genetics of tumors. The use of these techniques, consisting of exome sequencing, transcriptome, miRNome, chromosome alteration, genome, and epigenome analysis, has also been successfully applied to adrenocortical carcinoma (ACC). In fact, the analysis of large cohorts of patients allowed the stratification of ACC with different patterns of molecular alterations, associated with different outcomes, thus providing a novel m...
Source: Journal of Endocrinological Investigation - April 16, 2018 Category: Endocrinology Source Type: research

Decreased staging of differentiated thyroid cancer in patients with chronic lymphocytic thyroiditis
AbstractPurposeThe biological association between chronic lymphocytic thyroiditis (CLT) and differentiated thyroid cancer (DTC) has not been elucidated yet. The aim of the study was to assess whether the presence of CLT exerts any influence on clinical or histological presentation of DTC.MethodsNine hundred and seven consecutive patients with DTC treated in the years 1998 –2016 were divided into two groups according to the presence or absence of concomitant CLT. The statistical differences were analysed.ResultsOut of 907 patients included in the study, 331 were diagnosed with DTC and CLT (studied group), while 576 pa...
Source: Journal of Endocrinological Investigation - April 4, 2018 Category: Endocrinology Source Type: research

Clinical presentation and management of patients with primary hyperparathyroidism in Italy
AbstractPurposeEvaluation of the phenotype of primary hyperparathyroidism (PHPT), adherence to International Guidelines for parathyroidectomy (PTx), and rate of surgical cure.MethodFrom January 2014 –January 2016, we performed a prospective, multicenter study in patients with newly diagnosed PHPT. Biochemical and instrumental data were collected at baseline and during 1-year follow-up.ResultsOver the first year we enrolled 604 patients (age 61  ± 14 years), mostly women (83%), referred for further evaluation and treatment advice. Five hundred sixty-six patients had sporadic PHPT (93.7%, age ...
Source: Journal of Endocrinological Investigation - April 3, 2018 Category: Endocrinology Source Type: research

Correction to: Radioiodine ablation with 1,850 MBq in association with rhTSH in patients with differentiated thyroid cancer
AbstractUnfortunately, the fourth author ’s middle name was missed out in the original publication of this article. The complete correct name should read as follows. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 2, 2018 Category: Endocrinology Source Type: research

DNA methylation of genes regulating appetite and prediction of weight loss after bariatric surgery in obese individuals
AbstractPurposeEpigenetic traits are influenced by clinical variables; interaction between DNA methylation (DNAmeth) and bariatric surgery-induced weight loss has been scarcely explored. We investigated whether DNAmeth of genes encoding for molecules/hormones regulating appetite, food intake or obesity could predict successful weight outcome following Roux-en-Y gastric bypass (RYGB).MethodsForty-five obese individuals with no known comorbidities were stratified accordingly to weight decrease one-year after RYGB (excess weight loss, EWL  ≥ 50%: good responders, GR; EWL 
Source: Journal of Endocrinological Investigation - March 30, 2018 Category: Endocrinology Source Type: research

TSH evaluation in hypothyroid patients assuming liquid levothyroxine at breakfast or 30  min before breakfast
ConclusionsThis study confirms in a large set of patients that a liquid LT4 formulation can be taken directly at breakfast and potentially improve therapeutic compliance. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 26, 2018 Category: Endocrinology Source Type: research

Gabriella Morreale de Escobar (1930 –2017)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 26, 2018 Category: Endocrinology Source Type: research

MicroRNA expression profile of thyroid nodules in fine-needle aspiration cytology: a confirmatory series
ConclusionIn this study, we confirmed that a limited set of miRNAs can be used for the differential diagnosis of thyroid nodules. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 24, 2018 Category: Endocrinology Source Type: research

Predictors of fat-free mass loss 1  year after laparoscopic sleeve gastrectomy
AbstractPurposeLaparoscopic sleeve gastrectomy (LSG) is one of the most frequently performed bariatric surgery interventions because of its safety and efficacy. Nevertheless, concerns have been raised on its detrimental effect on patient nutritional state that can ultimately lead to the loss of fat-free mass (FFM). There is interest in identifying predictors for the early identification of patients at risk of this highly unwanted adverse because they could benefit of nutritional preventive interventions. Therefore, we investigated whether anthropometric parameters, body composition or resting energy expenditure (REE) measu...
Source: Journal of Endocrinological Investigation - March 24, 2018 Category: Endocrinology Source Type: research

Oxysterol species: reliable markers of oxidative stress in diabetes mellitus
AbstractPurposeTo assess the plasma oxysterol species 7-ketocholesterol (7-Kchol) and cholestane-3 β,5α,6β-triol (chol-triol) as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus (DM).MethodsIn total, 26 type 1 and 80 type 2 diabetes patients, along with 205 age- and gender-matched healthy controls, were included in this study. Oxysterols were quantified by liquid chromatography coupled with tandem mass spectrometry andN,N-dimethylglycine derivatization. Correlations between oxysterols and clinical/biochemical characteristics of the diabetes patients, and factors affecting 7-Kchol and ch...
Source: Journal of Endocrinological Investigation - March 21, 2018 Category: Endocrinology Source Type: research

Investigating the effect of testosterone by itself and in combination with letrozole on 1,25-dihydroxy vitamin D and FGF23 in male rats
AbstractBackgroundTestosterone deficiency might be associated with vitamin D levels in hypogonadal men, but it is not clear whether testosterone can affect vitamin D and fibroblast growth factor-23 (FGF23), either directly or indirectly via aromatization to estradiol. We aimed to investigate the role of testosterone on vitamin D metabolism and serum FGF23 in male rats.MethodsA total of 48 male rats were divided into 4 equal groups: sham; O, orchiectomy; O  + T, orchiectomized rats treated with testosterone; and O + T + L, orchiectomized rats treated with combination of testosterone and...
Source: Journal of Endocrinological Investigation - March 20, 2018 Category: Endocrinology Source Type: research

Joseph Boruwlaski: the last court dwarf of the History
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 20, 2018 Category: Endocrinology Source Type: research

Clinicopathologic risk factors for right paraesophageal lymph node metastasis in patients with papillary thyroid carcinoma
ConclusionsLymph node dissection, including RPELN dissection, should be performed for patients with PTC with a tumor diameter  ≥ 1 cm, multiple tumors, right-lobe tumors, right central compartment lymph node metastasis, or suspected lateral compartment lymph node metastasis. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 17, 2018 Category: Endocrinology Source Type: research

Specificity of late-night salivary cortisol measured by automated electrochemiluminescence immunoassay for Cushing ’s disease in an obese population
AbstractPurposeData about the specificity of late-night salivary cortisol (LNSC) in obese subjects are still conflicting. Therefore, with this study, we aimed to evaluate the specificity of LNSC measurement in an obese cohort with or without type 2 diabetes mellitus (T2DM) using an automated electrochemiluminescence immunoassay (ECLIA).MethodsA total number of 157 patients involving 40 healthy subjects (HS) with BMI  
Source: Journal of Endocrinological Investigation - March 17, 2018 Category: Endocrinology Source Type: research

From inflammation to sexual dysfunctions: a journey through diabetes, obesity, and metabolic syndrome
AbstractMetabolic diseases are associated with chronic low-grade inflammation, which has been indicated as a potential mediator of endothelial dysfunction and cardiovascular disease. Visceral adiposity is thought to be the starting condition of the inflammatory state through the release of inflammatory cytokines, including TNF-alpha, CRP, and IL-6, which in turn promote endothelial dysfunction, endothelial expression of chemokines (IL-1) and adhesion molecules (ICAM-1, VCAM-1, and P-selectin), and the inhibition of anti-atherogenic factors (adiponectin). Obesity, metabolic diseases, and diabetes, all conditions characteriz...
Source: Journal of Endocrinological Investigation - March 16, 2018 Category: Endocrinology Source Type: research

Combined BRAF V600E analysis and 99m Tc-MIBI scintigraphy can be a useful diagnostic tool in differentiated thyroid cancer patients with incomplete bio-chemical response to first radioiodine therapy (RAIT): a pilot investigation
ConclusionAlbeit obtained in a small retrospective series, our results suggest that the combination of BRAFV600E+ve mutation and MIBI −ve scintigraphy may be considered a negative prognostic clue, which predicts the absence of radioiodine uptake at pT-WBS in DTC patients with incomplete bio-chemical response to first RAIT. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 16, 2018 Category: Endocrinology Source Type: research

Lymph node location is a risk factor for papillary thyroid cancer-related death
ConclusionsThe presence of lymph node metastases in the N1b compartment should be considered as a risk factor for distant metastatic spread and for cancer-related death and included in post-surgery evaluation. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 16, 2018 Category: Endocrinology Source Type: research

Association of PON1 gene polymorphisms with polycystic ovarian syndrome risk: a meta-analysis of case –control studies
ConclusionsOur study has shown thatPON1− 108 C/T polymorphism might be associated with increased risk of PCOS under the allelic, homozygote, heterozygote, and dominant models. Additionally,PON1 192 Q/R and L55M polymorphisms were significantly related only in the allelic and recessive model, and in the heterozygote and dominant model, respectively. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 15, 2018 Category: Endocrinology Source Type: research

The AMPK-activator AICAR in thyroid cancer: effects on CXCL8 secretion and on CXCL8-induced neoplastic cell migration
AbstractPurposeThe AMPK-activator AICAR recently raised great interest for its anti-cancer properties. With specific regard to thyroid cancer, AICAR reduces cancer cell growth, invasion and metastasis. CXCL8, a chemokine with several recognized tumorigenic effects, is abundantly secreted in thyroid cancer microenvironment. The aim of this study was to investigate if AICAR could inhibit the basal and the TNF α-induced CXCL8 secretion in normal human thyroid cells (NHT) and in thyroid cancer cell lines TPC-1 and BCPAP (RET/PTC and BRAFV600e mutated, respectively).MethodsThe effect of AICAR on basal and CXCL8-induced ce...
Source: Journal of Endocrinological Investigation - March 15, 2018 Category: Endocrinology Source Type: research

Clinical impact of the new SIAPEC-IAP classification on the indeterminate category of thyroid nodules
ConclusionsThis analysis shows that the new SIAPEC-IAC criteria significantly increased the proportion of the overall TIR3 diagnosis. The division of TIR3 nodules into two subgroups (A and B) allowed a better evaluation of the oncologic risk and a better selection of patients to be referred to surgery. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 15, 2018 Category: Endocrinology Source Type: research

Effects of an individualized home-based unsupervised aerobic training on body composition and physiological parameters in obese adults are independent of gender
AbstractPurposeEvaluation of the effects of an individualized home-based unsupervised aerobic training on body composition, physical and physiological parameters in female and male obese adults.MethodsTwo hundred and twenty obese adults (age 47.9  ± 12.4 years; BMI 38.0 ± 7.2 kg/m2) entered the 4-month training program. Body composition, physiological and functional capacities were assessed pre- and post-intervention. All subjects were requested to perform unsupervised aerobic training with the intensity based on heart rate, walking speed and OMNI-RPE score corresponding to the i...
Source: Journal of Endocrinological Investigation - March 14, 2018 Category: Endocrinology Source Type: research

Does IGF-1 play a role in the etiopathogenesis of non-functioning adrenocortical adenoma?
This study included 50 female patients (mean age 54  years) with NFAs, 55 patients (mean age 48 years; 20 male, 35 female) with acromegaly and 38 female control subjects (mean age 58 years). Body mass index (BMI) and waist circumference (WC) of the subjects were recorded and blood samples for IGF-1 were taken. Insulin resistance was calculated usi ng the homeostatic model assessment (HOMA) score. Since most of the acromegaly patients had been using medicine that could have effected insulin resistance, HOMA scores were calculated only in patients with NFAs and the controls. Computerized tomography or magnetic...
Source: Journal of Endocrinological Investigation - March 14, 2018 Category: Endocrinology Source Type: research

Analysis of characteristics and outcomes by growth hormone treatment duration in adult patients in the Italian cohort of the Hypopituitary Control and Complications Study (HypoCCS)
ConclusionsThe results show that long-term GH treatment is associated with decreasing GH dose, increased IGF-I, decreased LDL-cholesterol and the presence of surrogate markers that help to give confidence in a diagnosis of GHD. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 13, 2018 Category: Endocrinology Source Type: research

Body composition and metabolic changes during a 520-day mission simulation to Mars
ConclusionsBased on these data, countermeasures may be envisioned to balance the potentially harmful effects of prolonged confinement, including a better exercise program, with accurate monitoring of (1) the individual activity and (2) the relationship between body composition and metabolic derangement. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 12, 2018 Category: Endocrinology Source Type: research

Components of metabolic syndrome in relation to plasma levels of retinol binding protein 4 (RBP4) in a cohort of people aged 65  years and older
AbstractPurposeElevated plasma concentration of retinol binding protein 4 (RBP4) has recently emerged as a potential risk factor as a component of developing metabolic syndrome (MS). Therefore, this study aimed to analyse the relationship between components of MS and concentrations of plasma RBP4 in a population of subjects 65  years and older.MethodsThe study sample consisted of 3038 (1591 male) participants of the PolSenior study, aged 65  years and older. Serum lipid profile, concentrations of RBP4, glucose, insulin, C-reactive protein, IL-6, and activity of aminotransferases were measured. Nutritional status ...
Source: Journal of Endocrinological Investigation - March 9, 2018 Category: Endocrinology Source Type: research

Daniel Lambert, a protagonist of real life with monstrous obesity in eighteenth century in England
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 8, 2018 Category: Endocrinology Source Type: research

Identification of key genes of papillary thyroid cancer using integrated bioinformatics analysis
ConclusionBCL2,CCND1 andCOL1A1 may be key genes for papillary thyroid carcinoma. Further molecular biological experiments are required to confirm the function of the identified genes. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 8, 2018 Category: Endocrinology Source Type: research

Efficacy and safety of long-term management of patients with chronic post-surgical hypoparathyroidism
ConclusionsTreatment of chronic PO-HypoPT with calcium and activated vitamin D metabolites is suboptimal and associated with an increased risk of renal complications. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 7, 2018 Category: Endocrinology Source Type: research

Efficacy of a new delivery system based on solid lipid microparticles for the oral administration of the non-conventional antioxidant IAC on a diabetes mouse model
ConclusionThe present study confirms that SLMs are promising drug carriers, which allow the oral administration of IAC ensuring its therapeutic efficacy. The concrete possibility to administer IAC per os represents a significant breakthrough in the putative consideration of this multi-radical scavenger in the diabetes therapeutic approach. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 6, 2018 Category: Endocrinology Source Type: research

Multi-centre phase IV trial to investigate the immunogenicity of a new liquid formulation of recombinant human growth hormone in adults with growth hormone deficiency
ConclusionsThe low immunogenicity profile of the liquid formulation was consistent with that for the freeze-dried formulation, and no new safety concerns were reported. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 27, 2018 Category: Endocrinology Source Type: research

A Spanish laborer with the most severe iodine deficiency disorder
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 24, 2018 Category: Endocrinology Source Type: research

Evaluation of adequacy of levo-thyroxine dosage in patients with differentiated thyroid carcinoma: correlation between morning and afternoon TSH determination
AbstractPurposeThe aim of this study was to judge the reliability of evaluating thyroid-stimulating hormone (TSH) and free thyroxine (f-T4) in the morning and afternoon in differentiated thyroid carcinoma (DTC) patients.MethodsWe evaluated 153 DTC patients, aged 61  ± 13 years, in active follow-up in our center after primary treatments and under stabilized levo-thyroxine (L-T4) posology. In each patient, morning and afternoon examinations were performed 1-3 months apart. Blood samples were collected at 08:00–09:00 h and 15:00–16:00 h. TSH and f-T4 were evaluated in both samp...
Source: Journal of Endocrinological Investigation - February 23, 2018 Category: Endocrinology Source Type: research

Small papillary thyroid carcinoma with minimal extrathyroidal extension should be managed as ATA low-risk tumor
ConclusionsmETE is an unfavorable prognostic factor in tumors larger than 1.5  cm, suggesting that, in the absence of other unfavorable characteristics, smaller tumors with mETE should be classified and managed as “low risk” tumors. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 22, 2018 Category: Endocrinology Source Type: research

Association between vitamin D deficiency and risk of thyroid cancer: a case –control study and a meta-analysis
ConclusionsA high level of circulating 25(OH)D was associated with a decreased TC risk. This association has important significance in public health and should, therefore, be further studied. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 20, 2018 Category: Endocrinology Source Type: research

Baseline and changes in serum uric acid independently predict 11-year incidence of metabolic syndrome among community-dwelling women
AbstractIntroductionMetabolic syndrome (MetS) is associated with an increased risk of major cardiovascular events. In women, increased serum uric acid (SUA) levels are associated with MetS and its components. However, whether baseline and changes in SUA predict incidence of MetS and its components remains unclear.MethodsThe subjects comprised 407 women aged 71  ± 8 years from a rural village. We have identified participants who underwent a similar examination 11 years ago, and examined the relationship between baseline and changes in SUA, and MetS based on the modified criteria of the National Ch...
Source: Journal of Endocrinological Investigation - February 19, 2018 Category: Endocrinology Source Type: research

The psychometric evaluation of the quality of life in short stature youth (QoLISSY) instrument for German children born small for gestational age
ConclusionPsychometric testing suggests that QoLISSY is a promising instrument to assess the HrQoL of young German people with SGA. Both versions (parent- and child report) appear to detect differences between SGA and other conditions (e.g. ISS). QoLISSY can be used in clinical studies, health service research, as well as in practice in children with SGA and their parents. For a cross-cultural application of the instrument in SGA, the tool needs be validated in sufficiently large SGA samples within respective countries. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 17, 2018 Category: Endocrinology Source Type: research

20S proteasome in the blood plasma of boys with cryptorchidism
ConclusionsWe believe that the 20S proteasome concentrations in the blood plasma of boys with cryptorchidism reflect the heat-induced apoptosis of germ cells. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 15, 2018 Category: Endocrinology Source Type: research

Rehabilitative orbital decompression for Graves ’ orbitopathy: results of a randomized clinical trial
ConclusionMLD provides a better result in terms of proptosis reduction compared to LD. The two techniques used here appear to have a similar safety profile in terms of POD. Pre-operative diplopia in the secondary gaze remains a major risk factor for development of POD. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 15, 2018 Category: Endocrinology Source Type: research

Phosphaturic mesenchymal tumors: what an endocrinologist should know
AbstractTumor-induced osteomalacia (TIO), also known as “oncogenic osteomalacia”, is a rare cause of osteomalacia. TIO often has an insidious onset characterized clinically by progressive muscle weakness and bone pain with fractures. The hallmark biochemical finding is a persistent low serum phosphorus concentration due to renal phosphate wasting. Th e vast majority of cases of TIO result from production of the phosphaturic hormone fibroblast growth factor 23 (FGF23) by a histologically distinctive mesenchymal tumor, termed “phosphaturic mesenchymal tumor” (PMT). Circulating FGF23 induces internaliz...
Source: Journal of Endocrinological Investigation - February 14, 2018 Category: Endocrinology Source Type: research

Continuously sustained elimination of iodine deficiency: a quarter of a century success in the Islamic Republic of Iran
ConclusionsBased on the results of this study, Iranian populations are consuming adequate iodine. The well-maintained and monitored USI program has improved the dietary iodine intakes of the population, and the country has achieved all criteria of a well-controlled IDD program. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 14, 2018 Category: Endocrinology Source Type: research

Up-regulation of miR-340-5p promotes progression of thyroid cancer by inhibiting BMP4
ConclusionsmiR-340-5p promotes thyroid cancer proliferation by inhibiting BMP4. Anti-miR-340-5p can be a promising strategy to control thyroid cancer. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 13, 2018 Category: Endocrinology Source Type: research

Evaluation of growth hormone response to GHRH plus arginine test in children with idiopathic short stature: role of peak time
AbstractPurposeTo describe the course of growth hormone response to growth hormone releasing hormone (GHRH) plus arginine provocative test in children with idiopathic short stature (ISS) and to evaluate the role of peak time.MethodsA retrospective study was performed analyzing 344 GHRH plus arginine provocative tests performed in children and adolescents with short stature. Serum GH levels were measured at four-time points (T0 ′, T30′, T45′ and T60′) and GH peak was defined as the maximum value at any time point. Mean (T30′–T60′) GH value and area under the curve (AUC) were calcula...
Source: Journal of Endocrinological Investigation - February 8, 2018 Category: Endocrinology Source Type: research

Association between systemic leptin and neurotensin concentration in adult individuals with and without type 2 diabetes mellitus
ConclusionsCirculating leptin is associated with higher proNT levels independent of diabetes, obesity and metabolic syndrome components; besides its effects on central leptin signaling, NT may influence energy balance by modulating circulating leptin concentration likely through a mechanism involving gut fat absorption. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 7, 2018 Category: Endocrinology Source Type: research

Relationship between 25 hydroxyvitamin D and lipid profile in Lebanese school children
The objective of this cross-sectional study is to determine the prevalence of vitamin D deficiency in a large sample of Lebanese schoolchildren and to evaluate the relationship between vitamin D and lipid profile.Methods969 Lebanese schoolchildren (505 boys and 464 girls) aged 8 –18 years were recruited from 10 schools of different socioeconomic status (SES). Non-fasting total cholesterol, triglycerides and HDL-Cholesterol (HDL-C) were measured. Non-HDL-C was calculated.ResultsThe prevalence of 25(OH)D deficiency (level below 20  ng/ml) is 56.6% (48.1% in boys, 65.7% in girls). There is no significant relat...
Source: Journal of Endocrinological Investigation - February 6, 2018 Category: Endocrinology Source Type: research

“Madonna of the carnation”: Leonardo da Vinci (1452–1519)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 6, 2018 Category: Endocrinology Source Type: research

Sir Jeffrey Hudson, the midget of the Queen Henrietta Marie
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 5, 2018 Category: Endocrinology Source Type: research

A Tuscan general with morbid obesity
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 5, 2018 Category: Endocrinology Source Type: research

Multiple endocrine neoplasia 2 in Cyprus: evidence for a founder effect
ConclusionsThe mutation p.Cys618Arg is by far the most prevalent mutation in Cyprus followed by other reported mutations of variable clinical significance. The provided molecular evidence speculates p.Cys618Arg mutation as an ancestral mutation that has spread in Cyprus due to a possible founder effect. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 2, 2018 Category: Endocrinology Source Type: research