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Brain morphometry and estimation of aging brain in subjects with congenital untreated isolated GH deficiency
ConclusionIGHD is primarily associated with similar absolute brain measurements, and a set of larger normalized volumes, and does not appear to alter the process of brain aging. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 16, 2024 Category: Endocrinology Source Type: research

An objective way to predict remission and relapse in Cushing disease using Bayes ’ theorem of probability
ConclusionsUsing various parameters, remission of Cushing disease can be predicted by applying Bayes ’ theorem of conditional probability with a sensitivity and a specificity of 82% and 94%, respectively. This study provided an objective way of predicting remission after TSS and relapse in patients with Cushing disease giving a weightage advantage to every parameter. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 15, 2024 Category: Endocrinology Source Type: research

Simplified integration of optimal self-management behaviors is associated with improved HbA1c in patients with type 1 diabetes
ConclusionsSix optimal self-management behaviors, especially CGM usage, were associated with improved glycemic control, emphasizing the feasibility of implementing a simplified version of DSMES in the routine clinical care.Registration number: ClinicalTrials.gov Identifier: NCT03610984 (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 11, 2024 Category: Endocrinology Source Type: research

The impact of overweight on lipid phenotype in different forms of dyslipidemia: a retrospective cohort study
ConclusionWhile dyslipidemias can be influenced by various factors, an important determinant may lie in genetics, frequently acting as an underlying cause of altered lipid profiles, even in cases of overweight conditions. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 11, 2024 Category: Endocrinology Source Type: research

Clinico-pathological factors associated with radioiodine refractory differentiated thyroid carcinoma status
ConclusionPredicting the occurrence of RAIR-disease in DTC patients may allow clinicians to focus on systemic redifferentiating strategies and/or local treatments for metastatic lesions rather than pursuing with ineffective RAI-therapies. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 5, 2024 Category: Endocrinology Source Type: research

Asprosin: its function as a novel endocrine factor in metabolic-related diseases
ConclusionAsprosin is a multifaceted protein with tissue-specific roles in various physiological and pathological processes. Further research is needed to fully understand the mechanisms and potential of asprosin as a therapeutic target. These insights could provide new directions for treatments targeting metabolic-related diseases. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 3, 2024 Category: Endocrinology Source Type: research

Long-acting exenatide does not prevent cognitive decline in mild cognitive impairment: a proof-of-concept clinical trial
ConclusionIn patients with MCI, a 32-week trial with slow-release exenatide had no beneficial effect on cognitive performance.Trial registration numberNCT03881371, registered on 21 July, 2016. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 2, 2024 Category: Endocrinology Source Type: research

Analysis of circulating osteoclast and osteogenic precursors in patients with Gorham-Stout disease
ConclusionThe analysis of circulating bone cell precursors, as well as of RANK-L, could be relevant as an additional diagnostic tool for these patients and could be exploited for therapeutic purposes. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 1, 2024 Category: Endocrinology Source Type: research

Body mass index is a good predictor of metabolic abnormalities in polycystic ovary syndrome
DiscussionBMI is a good predictor factor of metabolic changes in PCOS women at any age, and obesity is associated to the appearance of metabolic complications. Overweight and obese PCOS women should be addressed to perform a complete metabolic assessment. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 29, 2024 Category: Endocrinology Source Type: research

Refracture following vertebral fragility fracture when bone fragility is not recognized: summarizing findings from comparator arms of randomized clinical trials
ConclusionThe highest risk of subsequent VFFs or nVFFs was already detected within 2  years following the initial VFF. Thus, prompt interventions should be designed to improve the detection and treatment of VFFs, aiming to reduce the risk of future FFs and properly implement secondary preventive measures. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 29, 2024 Category: Endocrinology Source Type: research

Lipoprotein(a) is associated with recurrent cardiovascular events in patients with coronary artery disease and prediabetes or diabetes
ConclusionsThis study demonstrated that elevated Lp(a) levels were associated with an increased recurrent CVE risk in patients with CAD, particularly among those with pre-DM and DM, indicating that Lp(a) may provide incremental value in risk stratification in this population. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 29, 2024 Category: Endocrinology Source Type: research