PETC/CT with 18 F-Choline localizes hyperfunctioning parathyroid adenomas equally well in normocalcemic hyperparathyroidism as in overt hyperparathyroidism
Conclusions18F-FCH-PET/CT can be considered a first-line imaging technique for the identification of pathologic parathyroid glands in patients with normocalcemic and hypercalcemic hyperparathyroidism, even when the parathyroid volume is small. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 9, 2018 Category: Endocrinology Source Type: research

A Flemish Kermis by Peeter Baltens: fashion or Peyronie ’s disease?
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 9, 2018 Category: Endocrinology Source Type: research

“Crucifixion” (1512) in the Benedictine Monastery of Brugora
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 9, 2018 Category: Endocrinology Source Type: research

Use of administrative health databases to estimate incidence and prevalence of acromegaly in Piedmont Region, Italy
ConclusionsThis is the first population-based study conducted in Italy to estimate incidence and prevalence of acromegaly and results show a higher prevalence than previously reported. Although our algorithm requires proper validation, it constitutes a promising tool to describe the epidemiology of acromegaly. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 1, 2018 Category: Endocrinology Source Type: research

Precocious pubertal events in Chilean children: ethnic disparities
ConclusionIndigenous origin in Chile is an independent risk factor for precocious gonadarche and pubarche in boys but not in girls. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 25, 2018 Category: Endocrinology Source Type: research

Exposure to insulin degludec during pregnancy: report of a small series and review of the literature
ConclusionsIn summary, while awaiting for the results of an ongoing randomized controlled trial, data on six cases of degludec exposure during pregnancy reassuringly suggest no embryo –foetal toxicity. More information is needed before degludec can be safely recommended during pregnancy. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 24, 2018 Category: Endocrinology Source Type: research

Clinical features, diagnosis and therapy of pituicytoma: an update
ConclusionsDue to both low frequency and the absence of pathognomonic clinical and/or radiological features, formulating a suspicion diagnosis of PT represents a considerable challenge even for experienced professionals. The indication for treatment should be made on an individual basis, but it is inescapable in the presence of a visual field defect. The surgical approach has to be tailored according to the topography of the tumor and preoperative symptoms; the greatest challenges in accomplishing a gross total removal are represented by the degree of adherence and vascularization of the PT. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 20, 2018 Category: Endocrinology Source Type: research

Bone involvement and mineral metabolism in Williams ’ syndrome
AbstractContextThe previous studies suggested a possible increased risk of hypercalcaemia and reduced bone mineral density (BMD) in Williams ’ syndrome (WS). However, an extensive study regarding bone metabolism has never been performed.ObjectiveTo investigate bone health in young adults with WS.DesignCross-sectional study.SettingsEndocrinology and Metabolic Diseases and Medical Genetic Units.Patients29 WS young adults and 29 age- and sex-matched controls.Main outcome measuresIn all subjects, calcium, phosphorus, bone alkaline phosphatase (bALP), parathyroid hormone (PTH), 25-hydroxyvitamin D (25OHVitD), osteocalcin ...
Source: Journal of Endocrinological Investigation - July 20, 2018 Category: Endocrinology Source Type: research

Correction to: Age-specific reference values and cut-off points for anti-m üllerian hormone in infertile women following a long agonist treatment protocol for IVF
Unfortunately, the first author name was incorrectly published in the original publication. The complete correct name should read as follows. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 20, 2018 Category: Endocrinology Source Type: research

DNA methylation alterations as therapeutic prospects in thyroid cancer
ConclusionBased on what was discussed in this review, we suggest that integration of epigenetic and targeted therapies into conventional treatments will reduce the occurrence of refractory radioiodine differentiated thyroid cancer and improve the outcomes in aggressive thyroid cancer patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 10, 2018 Category: Endocrinology Source Type: research

The diagnostic accuracy of increased late night salivary cortisol for Cushing ’s syndrome: a real-life prospective study
ConclusionsLNSC measured in automated chemiluminescence is reliable in clinical practice: it present a high diagnostic accuracy to exclude hypercortisolism in patients with normal cortisol levels. MS could be used to reduce the number of false-positive results; nevertheless, some non-CS subjects with functional hypercortisolism could have a mild impairment of cortisol rhythm. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 9, 2018 Category: Endocrinology Source Type: research

Adjustment of insulin doses when switching from glargine 100  U/ml or detemir to degludec: an observational study
ConclusionsThe present results provide a suggestion for a simple method for the adjustment of basal and prandial insulin doses in type 1 diabetic patients, switching from glargine or detemir to degludec. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 9, 2018 Category: Endocrinology Source Type: research

The role of EIF1AX in thyroid cancer tumourigenesis and progression
ConclusionsAccording to our results, distinct mutations onEIF1AX may be related to different phenotypes/behaviours. Despite being a small series, which reflects the difficulty in retrieving PDTC and ATC surgical samples with well-differentiated and/or benign areas, our study may provide new insights into thyroid cancer tumourigenesis and dedifferentiation. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 2, 2018 Category: Endocrinology Source Type: research

Circulating insulin-like peptide 5 levels and its association with metabolic and hormonal parameters in women with polycystic ovary syndrome
AbstractPurposeInsulin-like peptide 5 (INSL5) is a gut peptide hormone that is a member of relaxin/insulin superfamily. Growing evidence implicates the crucial role of the peptide in some metabolisms including food intake, glucose homeostasis and reproductive system. Polycystic ovary syndrome (PCOS) is involved in both reproductive and metabolic issues. The aim of the study was determination of circulating levels of INSL5 alteration in women with PCOS and evaluation of the relationship between INSL5 and hormonal-metabolic parameters as well as carotid intima media thickness (cIMT).MethodsA total of 164 subjects were recrui...
Source: Journal of Endocrinological Investigation - June 28, 2018 Category: Endocrinology Source Type: research

Antithyroid drug treatment for Graves ’ disease: baseline predictive models of relapse after treatment for a patient-tailored management
ConclusionsBoth CSS and GREAT score are useful, although imperfect, tools to predict at baseline relapse of hyperthyroidism after treatment. In real life they may help the clinician to tailor a treatment for newly diagnosed Graves ’ hyperthyroidism. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 26, 2018 Category: Endocrinology Source Type: research

Thyroid hormones act as mitogenic and pro survival factors in rat ovarian follicles
ConclusionsTHs influence cell survival of ovarian granulosa cells. This effect likely contributes to the TH-induced follicle volume increase. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 22, 2018 Category: Endocrinology Source Type: research

Self-portrait with goiter: Antonio Ligabue
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 22, 2018 Category: Endocrinology Source Type: research

How much of the predisposition to Hashimoto ’s thyroiditis can be explained based on previously reported associations?
ConclusionsWe analyzed genetic regions commonly and most significantly associated with autoimmune thyroid disorders in the literature, on a carefully selected cohort. Our results indicated a lack of possibility to predict the risk of HT development, even with a multivariate model. We therefore conclude that strong associations of single genetic regions with HT should be interpreted with great caution. We believe that a change in the attitude towards genetic association analyses of HT predisposition is necessary. Studies including multiple factors simultaneously are needed to unravel the intricacies of genetic associations ...
Source: Journal of Endocrinological Investigation - June 21, 2018 Category: Endocrinology Source Type: research

Therapeutic effects of obeticholic acid (OCA) treatment in a bleomycin-induced pulmonary fibrosis rat model
ConclusionsIn conclusion, our results demonstrate a significant therapeutic effect of OCA in already established PF. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 19, 2018 Category: Endocrinology Source Type: research

Relationship between serum cholesterol and Graves ’ orbitopathy (GO): a confirmatory study
ConclusionsOur study confirms a relationship between the presence of GO and cholesterol in patients with GD of recent onset. Whether lowering of cholesterol ameliorates, GO remains to be established. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 19, 2018 Category: Endocrinology Source Type: research

High serum osteopontin levels are associated with prevalent fractures and worse lipid profile in post-menopausal women with type 2 diabetes
ConclusionsIn post-menopausal women with T2DM, OPN might be a useful marker of fracture and worse lipid profile. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 18, 2018 Category: Endocrinology Source Type: research

Peptide receptor radionuclide therapy with 177 Lu-DOTA-TATE as a promising treatment of malignant insulinoma: a series of case reports and literature review
ConclusionsAfter the start of177Lu-DOTA-TATE all patients achieved hypoglycaemia symptomatic control and had evident improvement of their quality of life. Three patients showed imagiological improvement suggesting reduced tumour load. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 9, 2018 Category: Endocrinology Source Type: research

High-dose intravenous methylprednisolone therapy in patients with Graves ’ orbitopathy is associated with the increased activity of factor VIII
AbstractPurposeVenous thromboembolic events (VTE), with their life-threatening manifestation as pulmonary embolism, are potential adverse effects of intravenous methylprednisolone (IVMP) pulse therapy, partially due to a hypercoagulable state. The aim of the study was to analyze the influence of IVMP on selected hemostatic parameters in patients with moderate-to-severe Graves ’ orbitopathy (GO).Methods26 euthyroid patients with GO were treated with 12 pulses of IVMP (6  × 0.5, 6 × 0.25 g every week). Hemostatic variables [factor (F) II, FV, FVII, FVIII, fibrinogen, antithr...
Source: Journal of Endocrinological Investigation - June 9, 2018 Category: Endocrinology Source Type: research

Clinical analysis of cervical lymph node metastasis risk factors in patients with papillary thyroid microcarcinoma
ConclusionsAccording to the clinicopathological characteristics of PTMC, the cervical lymph nodes should be correctly evaluated to guide the surgical treatment. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 6, 2018 Category: Endocrinology Source Type: research

Follow-up of parenchymal changes in the thyroid gland with diffuse autoimmune thyroiditis in children prior to the development of papillary thyroid carcinoma
ConclusionsSonographic follow-up assessments warrant further exploration as a strategy to determine PTC susceptibility in the paediatric population. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 5, 2018 Category: Endocrinology Source Type: research

Advances and controversies in the classification and grading of pituitary tumors
ConclusionsThe 2017 WHO Classification of Pituitary Tumors provides a more solid basis for accurate and reliable prognostic assessment of these lesions. Further progress undoubtedly will be made as the recommendations of this update are incorporated in to routine use. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 1, 2018 Category: Endocrinology Source Type: research

Is elevated urotensin II level a predictor for increased cardiovascular risk in subjects with acromegaly?
ConclusionElevated UII levels are associated with severity of cardiovascular risk factors including cIMT and EFT in acromegalic subjects. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 26, 2018 Category: Endocrinology Source Type: research

A case of drug-induced Graves ’ Orbitopathy after combination therapy with Tremelimumab and Durvalumab
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 26, 2018 Category: Endocrinology Source Type: research

Increased serum interleukin-37 (IL-37) levels correlate with oxidative stress parameters in Hashimoto ’s thyroiditis
AbstractPurpose Interleukin-37 (IL-37), member of the IL-1 family, is a natural suppressor of immune and inflammatory responses. Increased serum IL-37 levels were observed in several autoimmune diseases, including Graves ’ disease. To our knowledge, no data on Hashimoto’s thyroiditis (HT) are available in the literature.Methods Aim of our study was to measure serum IL-37 levels and evaluate their relationship, if any, with oxidative stress markers in HT patients. We enrolled 45 euthyroid HT patients (5 M e 40 F, median age 40  years) and 50 age- and sex-matched healthy controls. None was underl-thyroxi...
Source: Journal of Endocrinological Investigation - May 23, 2018 Category: Endocrinology Source Type: research

Goliath as an acromegalic giant by Giovanni Lanfranco (1582 –1647)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 23, 2018 Category: Endocrinology Source Type: research

Testosterone-mediated activation of androgenic signalling sustains in vitro the transformed and radioresistant phenotype of rhabdomyosarcoma cell lines
ConclusionsOur results suggest that androgens sustain and improve RMS transformed and radioresistant phenotype, and therefore, their therapeutic application should be avoided in RMS post puberal patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 22, 2018 Category: Endocrinology Source Type: research

The association between circulating irisin levels and different phenotypes of polycystic ovary syndrome
ConclusionsCirculating irisin may allow physicians to establish which women merit screening by a biomarker for PCOS. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 21, 2018 Category: Endocrinology Source Type: research

Irisin levels increase after treatment in patients with newly diagnosed Hashimoto thyroiditis
AbstractPurposeIrisin is a newly identified myokine secreted by skeletal muscle and has significant effects on body metabolism. Thyroidal functional state has a profound influence on the metabolism of human body. Therefore, the aim of this study was to investigate the possible changes in serum irisin concentrations before and after treatment in hypothyroid subjects.MethodsThe study included 26 patients with overt hypothyroidism due to Hashimoto thyroiditis and 19 healthy subjects. Baseline serum thyroid function tests and presence of thyroid autoantibodies and levels of creatine kinase (CK) and irisin were measured in both...
Source: Journal of Endocrinological Investigation - May 18, 2018 Category: Endocrinology Source Type: research

Adverse effects of media reports on the treatment of osteoporosis
ConclusionsThere is a gap between the application of clinical recommendations and patient perceptions of osteoporosis and its treatment. There is a need for better education of patients and practitioners aimed at recognizing the serious consequences of fractures and understanding the expected benefits and potential risks of treatment. Media reports that disseminate evidence-based information on the balance of benefits and risks could help to reduce the osteoporosis treatment gap and mitigate the crisis in osteoporosis care. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 14, 2018 Category: Endocrinology Source Type: research

Acromegaly is associated with high fibroblast growth factor-21 levels
ConclusionFGF-21 levels were increased significantly in acromegaly group. Increased FGF-21 levels were significantly and independently associated with the state of acromegaly. Acromegaly may also be a FGF-21 resistance state independent from insulin resistance, glucose intolerance, obesity, hypertension and dyslipidemia. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 12, 2018 Category: Endocrinology Source Type: research

Mechanisms underlying the weight loss effects of RYGB and SG: similar, yet different
AbstractThe worldwide obesity epidemic continues unabated, adversely impacting upon global health and economies. People with severe obesity suffer the greatest adverse health consequences with reduced life expectancy. Currently, bariatric surgery is the most effective treatment for people with severe obesity, resulting in marked sustained weight loss, improved obesity-associated comorbidities and reduced mortality. Sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB), the most common bariatric procedures undertaken globally, engender weight loss and metabolic improvements by mechanisms other than restriction and mal...
Source: Journal of Endocrinological Investigation - May 5, 2018 Category: Endocrinology Source Type: research

Italian consensus on diagnosis and treatment of differentiated thyroid cancer: joint statements of six Italian societies
The objective of this consensus is to inform clinicians, patients, researchers, and health policy makers about the best strategies (and their limitations) relating to the diagnosis and treatment of differentiated thyroid cancer. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 4, 2018 Category: Endocrinology Source Type: research

Can the positive association of osteocalcin with testosterone be unmasked when the preeminent hypothalamic –pituitary regulation of testosterone production is impaired? The model of spinal cord injury
AbstractPurposeOsteocalcin (OCN), released from the bone matrix during the resorption phase, in its undercarboxylated form, stimulates testosterone (T) biosynthesis in mouse and a loss-of-function mutation of its receptor was associated with hypergonadotropic hypogonadism in humans. Nevertheless, when population-based studies have explored the OCN-T association, conflicting results have been reported. Hypothesizing that the evidence of a positive association between OCN and T could have been hindered by the preeminent role of a well-functioning hypothalamus –pituitary axis in promoting T biosynthesis, we explored thi...
Source: Journal of Endocrinological Investigation - May 4, 2018 Category: Endocrinology Source Type: research

“Madonna of the Pinks” and “Madonna Dell’Impannata”: Raphael Sanzio (1483–1520)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 2, 2018 Category: Endocrinology Source Type: research

Diagnosis and treatment of lipodystrophy: a step-by-step approach
ConclusionsHere, we describe the clinical presentation of known types of lipodystrophy, present an algorithm for differential diagnosis of lipodystrophy, and suggest specific steps to recognize and diagnose lipodystrophy in the clinical setting. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 27, 2018 Category: Endocrinology Source Type: research

Dissonance among treatment algorithms for hyperglycemia in type 2 diabetes: an egalitarian dialog
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 27, 2018 Category: Endocrinology Source Type: research

The mutational analysis in the diagnostic work-up of thyroid nodules: the real impact in a center with large experience in thyroid cytopathology
ConclusionsOur study established mutational rates forBRAF andRAS genes in a large series of FNA specimens.BRAF mutations were confirmed as highly specific but not able to improve cytological diagnosis, whileRAS testing proved effective in assessing malignancy in nodules with indeterminate and benign cytology. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 27, 2018 Category: Endocrinology Source Type: research

Adipokine levels in overweight women with early-onset gestational diabetes mellitus
AbstractPurposeThe study of adipokines in overweight women with early-onset (diagnosed before 20  weeks) gestational diabetes mellitus (GDM) could help to understand the ethiopathological mechanisms of this disorder. Our aim was to assess adipokine levels in overweight pregnant women with early-onset GDM compared to patients with standard-onset (diagnosed at 24–28 weeks) GDM and to glucose- tolerant women at the same gestational ages.MethodsThis nested case –control study included 133 overweight pregnant women: 33 with early-onset (diagnosed 
Source: Journal of Endocrinological Investigation - April 25, 2018 Category: Endocrinology Source Type: research

Phosphoproteome profiling revealed abnormally phosphorylated AMPK and ATF2 involved in glucose metabolism and tumorigenesis of GH-PAs
ConclusionThese findings suggest that decreased phosphorylation of the AMPK/ATF2 pathway may be critical for glucose metabolism and tumorigenesis in GH-PAs. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 24, 2018 Category: Endocrinology Source Type: research

mRECIST criteria to assess recurrent thyroid carcinoma treatment response after radiofrequency ablation: a prospective study
ConclusionRFA is a safe procedure to treat the viable tumour tissue and to reduce the RTC volume; as to the criteria to assess treatment response, mRECIST appears to be more accurate. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 23, 2018 Category: Endocrinology Source Type: research

Elevation of isoprostanes in polycystic ovary syndrome and its relationship with cardiovascular risk factors
AbstractPurposeTo evaluate the plasma level of 8-isoprostanes in women with polycystic ovary syndrome. To also investigate whether there is a relationship between 8-isoprostanes and several cardiovascular risk factors.MethodsA total of 125 women with polycystic ovary syndrome and 169 healthy women were enrolled in this case –control study. 8-Isoprostanes and different parameters were measured in all subjects. Patients were evaluated for the presence of polycystic ovary syndrome according to the Rotterdam Consensus Conference criteria.Results8-Isoprostanes levels were significantly higher in patients with polycystic o...
Source: Journal of Endocrinological Investigation - April 23, 2018 Category: Endocrinology Source Type: research

Increased fibulin-1 plasma levels in polycystic ovary syndrome (PCOS) patients: possible contribution to the link between PCOS and cardiovascular risk
ConclusionsOur data could contribute to explain the hypothesized increased cardiovascular risk and vascular damage in patients with PCOS. A better understanding of the cellular and molecular mechanisms involved in cardiometabolic disorders associated with PCOS is mandatory to identify new therapeutic strategies to eventually prevent the progression of cardiovascular diseases in these patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 21, 2018 Category: Endocrinology Source Type: research

Effects of growth hormone on pregnancy rates of patients with thin endometrium
AbstractPurposeTo investigate whether growth hormone (GH) could improve pregnancy rates of patients with thin endometrium by clinical study and laboratory experiments.Materials and methodsNinety-three patients were randomized to either the GH-received group (40) or the routine exogenous administration of estrogens control group (53) for clinical study. The human endometrial carcinoma cell line RL95-2 was used for testing the role of GH with Western blot and real-time PCR by exposure to various concentrations of GH (0.1 nM,1 nM,10 nM,100 nM).ResultsPatients treated with GH had a significantly (P 
Source: Journal of Endocrinological Investigation - April 18, 2018 Category: Endocrinology Source Type: research

Lack of association between obesity and aggressiveness of differentiated thyroid cancer
ConclusionsObesity was not associated with aggressive features in this prospective, European cohort of patients with DTC. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 17, 2018 Category: Endocrinology Source Type: research

Adrenocortical carcinoma: the dawn of a new era of genomic and molecular biology analysis
AbstractOver the last decade, the development of novel and high penetrance genomic approaches to analyze biological samples has provided very new insights in the comprehension of the molecular biology and genetics of tumors. The use of these techniques, consisting of exome sequencing, transcriptome, miRNome, chromosome alteration, genome, and epigenome analysis, has also been successfully applied to adrenocortical carcinoma (ACC). In fact, the analysis of large cohorts of patients allowed the stratification of ACC with different patterns of molecular alterations, associated with different outcomes, thus providing a novel m...
Source: Journal of Endocrinological Investigation - April 16, 2018 Category: Endocrinology Source Type: research