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The direct impact of pegvisomant on osteoblast functions and bone development
ConclusionThis study provides a first evidence of the impact of PEG on osteoblast functions both in vitro and in vivo. These findings may have clinically relevant implications for the management of skeletal health in subjects with acromegaly. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 30, 2023 Category: Endocrinology Source Type: research

Comment on: Semaglutide and cardiovascular outcomes in obesity without diabetes
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 29, 2023 Category: Endocrinology Source Type: research

DACH1 attenuated PA-induced renal tubular injury through TLR4/MyD88/NF- κB and TGF-β/Smad signalling pathway
ConclusionsThis study proved that sPA presents a risk factor for kidney injuries and DACH1 might serve as a protective target against renal function deterioration in diabetic patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 26, 2023 Category: Endocrinology Source Type: research

Single-cell and bulk RNA sequencing reveal heterogeneity and diagnostic markers in papillary thyroid carcinoma lymph-node metastasis
ConclusionsThis study explored the heterogeneity of PTC LNM using scRNA-seq. By combining with bulk RNA-seq data, diagnostic markers were explored and the model was established. Clinical diagnostic efficacy of S100A2 and DIO2 was validated and the treatment potential of DIO2 was discovered. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 26, 2023 Category: Endocrinology Source Type: research

Comparative assessment of immunogenicity of recombinant insulin Aspart from BioGenomics and its originator NovoRapid ® in adult patients with type 2 diabetes mellitus
ConclusionsThe immunogenicity assessment based on the overall incidence of patients positive for AIA, changes in incidence of patients positive for AIA post-baseline, TEAR rates and absence of neutralizing antibodies, were found to be apparently similar and comparable in both the treatment groups (BGL –ASP and RMP). We conclude from our studies that the immunogenicity of BGL–ASP is similar and comparable to RMP and the observed immunogenicity in terms of anti-insulin Aspart antibody levels had no impact on the biological activity of insulin. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 26, 2023 Category: Endocrinology Source Type: research

DACH1 attenuated PA-induced renal tubular injury through TLR4/MyD88/NF- κB and TGF-β/Smad signalling pathway
ConclusionsThis study proved that sPA presents a risk factor for kidney injuries and DACH1 might serve as a protective target against renal function deterioration in diabetic patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 26, 2023 Category: Endocrinology Source Type: research

Single-cell and bulk RNA sequencing reveal heterogeneity and diagnostic markers in papillary thyroid carcinoma lymph-node metastasis
ConclusionsThis study explored the heterogeneity of PTC LNM using scRNA-seq. By combining with bulk RNA-seq data, diagnostic markers were explored and the model was established. Clinical diagnostic efficacy of S100A2 and DIO2 was validated and the treatment potential of DIO2 was discovered. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 26, 2023 Category: Endocrinology Source Type: research

Comparative assessment of immunogenicity of recombinant insulin Aspart from BioGenomics and its originator NovoRapid ® in adult patients with type 2 diabetes mellitus
ConclusionsThe immunogenicity assessment based on the overall incidence of patients positive for AIA, changes in incidence of patients positive for AIA post-baseline, TEAR rates and absence of neutralizing antibodies, were found to be apparently similar and comparable in both the treatment groups (BGL –ASP and RMP). We conclude from our studies that the immunogenicity of BGL–ASP is similar and comparable to RMP and the observed immunogenicity in terms of anti-insulin Aspart antibody levels had no impact on the biological activity of insulin. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 26, 2023 Category: Endocrinology Source Type: research

Twenty-four hour Holter ECG in normocalcemic and hypercalcemic patients with hyperparathyroidism
ConclusionsNCPHPT patients did not experience an increased occurrence of arrhythmias compared to controls, while PHPT patients showed an increased occurrence compared to both controls and NCPHPT. Our findings are most probably related to the short QTc interval caused by hypercalcemia observed in PHPT patients, but not in NCPHPT. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 23, 2023 Category: Endocrinology Source Type: research

Calcium/phosphate ratio: an additional tool for the clinical management of asymptomatic primary hyperparathyroidism?
ConclusionsIn PHPT Ca/P ratio is associated with increased biochemical and clinical severity of disease and represents a direct indicator of clinical bone damage. However, it does not seem an additional tool to identify aPHPT patients reaching surgical indication. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 21, 2023 Category: Endocrinology Source Type: research

IgG4 serum levels in Graves ’ orbitopathy
ConclusionsOur results suggest that, within GD, there is no relationship between serum IgG4 and GO. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 21, 2023 Category: Endocrinology Source Type: research

Calcium/phosphate ratio: an additional tool for the clinical management of asymptomatic primary hyperparathyroidism?
ConclusionsIn PHPT Ca/P ratio is associated with increased biochemical and clinical severity of disease and represents a direct indicator of clinical bone damage. However, it does not seem an additional tool to identify aPHPT patients reaching surgical indication. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 21, 2023 Category: Endocrinology Source Type: research