The impact of isolated maternal hypothyroxinemia during the first and second trimester of gestation on pregnancy outcomes: an intervention and prospective cohort study in China
AbstractObjectivesTo explore the effect of isolated maternal hypothyroxinemia (IMH) during the first and second trimester of gestation on pregnancy outcomes. To explore whether levothyroxine (L-T4) treatment of women who had IMH identified in the first trimester improves pregnancy outcomes.MethodsWomen in the early pregnancy in the iodine-sufficient area (n = 3398) were recruited to this prospective cohort study (ChiCTR-TRC-12002326). Serum thyroid-stimulating hormone (TSH), free thyroxine (FT4), and thyroid peroxidase antibody (TPOAb) were detected. Women with IMH before 12 weeks chose to receive L-T4 o...
Source: Journal of Endocrinological Investigation - October 17, 2018 Category: Endocrinology Source Type: research

Thyroid ultrasonography reporting: consensus of Italian Thyroid Association (AIT), Italian Society of Endocrinology (SIE), Italian Society of Ultrasonography in Medicine and Biology (SIUMB) and Ultrasound Chapter of Italian Society of Medical Radiology (SIRM)
AbstractThyroid ultrasonography (US) is the gold standard for thyroid imaging and its widespread use is due to an optimal spatial resolution for superficial anatomic structures, a low cost and the lack of health risks. Thyroid US is a pivotal tool for the diagnosis and follow-up of autoimmune thyroid diseases, for assessing nodule size and echostructure and defining the risk of malignancy in thyroid nodules. The main limitation of US is the poor reproducibility, due to the variable experience of the operators and the different performance and settings of the equipments. Aim of this consensus statement is to standardize the...
Source: Journal of Endocrinological Investigation - October 16, 2018 Category: Endocrinology Source Type: research

Maternal estradiol and progesterone concentrations among singleton spontaneous pregnancies during the first trimester
AbstractBackgroundPregnancy hormonal milieu represents a crucial determinant of fetal outcome. We aim to determine 17 β-estradiol (E2) and progesterone (PGT) concentrations in spontaneous pregnancies during the first trimester. In addition, we aim to determineE2 concentrations as a function of gestational age (GA) and PGT.MethodsBetween November 2015 and March 2017, 104 healthy women of at least 18  years undergoing medical consultation for voluntary interruption of pregnancy were enrolled in an observational study at University Hospital ASST Fatebenefratelli Sacco, Milan, Italy. Only singleton pregnancies betwee...
Source: Journal of Endocrinological Investigation - October 15, 2018 Category: Endocrinology Source Type: research

Clinical inertia, reverse clinical inertia, and medication non-adherence in type 2 diabetes
ConclusionsBoth clinical inertia and medication non-adherence remain significant barriers to optimal glycemic targets in type 2 diabetes. Moreover, part of clinical inertia may be a way through which clinicians face current uncertainty in medicine, including some dissonance among therapeutic guidelines. Scientific associations should find an agreement about how to measure and report clinical inertia in clinical practice and should exhort clinicians to consider reverse clinical inertia as a cause of persisting inappropriate therapy in vulnerable patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 6, 2018 Category: Endocrinology Source Type: research

The epigenetic landscape in the cardiovascular complications of diabetes
AbstractA growing body of evidence suggests that epigenetic modifications —changes to the genome that do not involve changes in DNA sequence—may significantly derail transcriptional programs implicated in angiogenesis, oxidative stress and inflammation, thus fostering cardiovascular damage in patients with diabetes. Notably, adverse epigenetic signals acquired over th e life course can be transmitted to the offspring, and may contribute to early cardiovascular phenotypes in the young generations. Hyperglycaemia and insulin resistance—key hallmarks of diabetes—induce an array of epigenetic modificati...
Source: Journal of Endocrinological Investigation - October 5, 2018 Category: Endocrinology Source Type: research

Fasting glucagon-like peptide 1 concentration is associated with lower carbohydrate intake and increases with overeating
ConclusionHigher plasma GLP-1 concentrations prior to ad libitum food intake were associated with lower carbohydrate intake and lower simple sugar ingestion, indicating a possible role of the GLP-1 in the reward pathway regulating simple sugar intake.Trial registrationClinicalTrials.gov identifier: NCT00342732. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 3, 2018 Category: Endocrinology Source Type: research

Quantitative proteomics analysis of sporadic parathyroid adenoma tissue samples
ConclusionThis exploratory study demonstrates the feasibility of proteomics approach in finding the dysregulated proteins in benign parathyroid adenomas, and our preliminary results suggest that MAPK, PLC and PI signalling pathways and chromatin organization are involved in parathyroid tumorigenesis. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 3, 2018 Category: Endocrinology Source Type: research

Genome-wide association analysis suggests novel loci for Hashimoto ’s thyroiditis
AbstractPurposeHashimoto ’s thyroiditis (HT) is the most common form of autoimmune thyroid diseases. Current knowledge of HT genetics is limited, and not a single genome-wide association study (GWAS) focusing exclusively on HT has been performed to date. In order to decipher genetic determinants of HT, we performed the fi rst GWAS followed by replication in a total of 1443 individuals from Croatia.MethodsWe performed association analysis in a discovery cohort comprising 405 cases and 433 controls. We followed up 13 independent signals (P 
Source: Journal of Endocrinological Investigation - October 3, 2018 Category: Endocrinology Source Type: research

Treating varicocele in 2018: current knowledge and treatment options
ConclusionsVaricocele repair seems to represent a cost-effective therapeutic option for all males (both adolescent and adults) with a clinical varicocele in the presence of testicular hypotrophy, worsening sperm alterations or infertility. On the other hand, some investigators questioned the role of varicocelectomy in the era of assisted reproduction. Thus, a better understanding of the pathophysiology of varicocele-associated male subfertility is of paramount importance to elucidating the deleterious effects of varicocele on spermatogenesis and possibly formulating new treatment strategies. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 3, 2018 Category: Endocrinology Source Type: research

Effects of metabolic abnormalities, hyperandrogenemia and clomiphene on liver function parameters among Chinese women with polycystic ovary syndrome: results from a randomized controlled trial
ConclusionsAmong PCOS women, metabolic abnormalities and hyperandrogenemia impaired different liver function parameters. Clomiphene could decrease the bilirubin and bile acid levels while acupuncture had no obvious effect on liver function. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 3, 2018 Category: Endocrinology Source Type: research

Exophthalmos or pseudo-exophthalmos in the Last Judgement (1535 –1541) by Michelangelo Buonarroti (1475–1564)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 3, 2018 Category: Endocrinology Source Type: research

Fasting glucagon-like peptide 1 concentration is associated with lower carbohydrate intake and increases with overeating
ConclusionHigher plasma GLP-1 concentrations prior to ad libitum food intake were associated with lower carbohydrate intake and lower simple sugar ingestion, indicating a possible role of the GLP-1 in the reward pathway regulating simple sugar intake.Trial registrationClinicalTrials.gov identifier: NCT00342732. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 3, 2018 Category: Endocrinology Source Type: research

Quantitative proteomics analysis of sporadic parathyroid adenoma tissue samples
ConclusionThis exploratory study demonstrates the feasibility of proteomics approach in finding the dysregulated proteins in benign parathyroid adenomas, and our preliminary results suggest that MAPK, PLC and PI signalling pathways and chromatin organization are involved in parathyroid tumorigenesis. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 3, 2018 Category: Endocrinology Source Type: research

Genome-wide association analysis suggests novel loci for Hashimoto ’s thyroiditis
AbstractPurposeHashimoto ’s thyroiditis (HT) is the most common form of autoimmune thyroid diseases. Current knowledge of HT genetics is limited, and not a single genome-wide association study (GWAS) focusing exclusively on HT has been performed to date. In order to decipher genetic determinants of HT, we performed the fi rst GWAS followed by replication in a total of 1443 individuals from Croatia.MethodsWe performed association analysis in a discovery cohort comprising 405 cases and 433 controls. We followed up 13 independent signals (P 
Source: Journal of Endocrinological Investigation - October 3, 2018 Category: Endocrinology Source Type: research

Treating varicocele in 2018: current knowledge and treatment options
ConclusionsVaricocele repair seems to represent a cost-effective therapeutic option for all males (both adolescent and adults) with a clinical varicocele in the presence of testicular hypotrophy, worsening sperm alterations or infertility. On the other hand, some investigators questioned the role of varicocelectomy in the era of assisted reproduction. Thus, a better understanding of the pathophysiology of varicocele-associated male subfertility is of paramount importance to elucidating the deleterious effects of varicocele on spermatogenesis and possibly formulating new treatment strategies. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 3, 2018 Category: Endocrinology Source Type: research

Effects of metabolic abnormalities, hyperandrogenemia and clomiphene on liver function parameters among Chinese women with polycystic ovary syndrome: results from a randomized controlled trial
ConclusionsAmong PCOS women, metabolic abnormalities and hyperandrogenemia impaired different liver function parameters. Clomiphene could decrease the bilirubin and bile acid levels while acupuncture had no obvious effect on liver function. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 3, 2018 Category: Endocrinology Source Type: research

Exophthalmos or pseudo-exophthalmos in the Last Judgement (1535 –1541) by Michelangelo Buonarroti (1475–1564)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 3, 2018 Category: Endocrinology Source Type: research

Should the use of neck-ultrasonography be reduced during the follow-up of differentiated thyroid cancer patients with undetectable or low (i.e., & lt;  1 µg/L) thyroglobulin levels and negative thyroglobulin antibody?
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 1, 2018 Category: Endocrinology Source Type: research

Clinical and genetic characteristics of familial hypercholesterolemia patients with type 2 diabetes
ConclusionsAlthough there were not many differences in the clinical, lipid and genetic aspects of HeFH patients with and without T2DM, T2DM and HbA1c were associated with worse coronary lesions, suggesting that diabetes and the degree of blood glucose control are also important determinants of cardiovascular disease in these patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 1, 2018 Category: Endocrinology Source Type: research

Components of metabolic syndrome in relation to plasma levels of retinol binding protein 4 (RBP4) in a cohort of people aged 65  years and older
AbstractPurposeElevated plasma concentration of retinol binding protein 4 (RBP4) has recently emerged as a potential risk factor as a component of developing metabolic syndrome (MS). Therefore, this study aimed to analyse the relationship between components of MS and concentrations of plasma RBP4 in a population of subjects 65  years and older.MethodsThe study sample consisted of 3038 (1591 male) participants of the PolSenior study, aged 65  years and older. Serum lipid profile, concentrations of RBP4, glucose, insulin, C-reactive protein, IL-6, and activity of aminotransferases were measured. Nutritional status ...
Source: Journal of Endocrinological Investigation - October 1, 2018 Category: Endocrinology Source Type: research

Phosphaturic mesenchymal tumors: what an endocrinologist should know
AbstractTumor-induced osteomalacia (TIO), also known as “oncogenic osteomalacia”, is a rare cause of osteomalacia. TIO often has an insidious onset characterized clinically by progressive muscle weakness and bone pain with fractures. The hallmark biochemical finding is a persistent low serum phosphorus concentration due to renal phosphate wasting. Th e vast majority of cases of TIO result from production of the phosphaturic hormone fibroblast growth factor 23 (FGF23) by a histologically distinctive mesenchymal tumor, termed “phosphaturic mesenchymal tumor” (PMT). Circulating FGF23 induces internaliz...
Source: Journal of Endocrinological Investigation - October 1, 2018 Category: Endocrinology Source Type: research

Association between vitamin D deficiency and risk of thyroid cancer: a case –control study and a meta-analysis
ConclusionsA high level of circulating 25(OH)D was associated with a decreased TC risk. This association has important significance in public health and should, therefore, be further studied. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 1, 2018 Category: Endocrinology Source Type: research

Efficacy of a new delivery system based on solid lipid microparticles for the oral administration of the non-conventional antioxidant IAC on a diabetes mouse model
ConclusionThe present study confirms that SLMs are promising drug carriers, which allow the oral administration of IAC ensuring its therapeutic efficacy. The concrete possibility to administer IAC per os represents a significant breakthrough in the putative consideration of this multi-radical scavenger in the diabetes therapeutic approach. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 1, 2018 Category: Endocrinology Source Type: research

Should the use of neck-ultrasonography be reduced during the follow-up of differentiated thyroid cancer patients with undetectable or low (i.e., & lt;  1 µg/L) thyroglobulin levels and negative thyroglobulin antibody?
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 1, 2018 Category: Endocrinology Source Type: research

Up-regulation of miR-340-5p promotes progression of thyroid cancer by inhibiting BMP4
ConclusionsmiR-340-5p promotes thyroid cancer proliferation by inhibiting BMP4. Anti-miR-340-5p can be a promising strategy to control thyroid cancer. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 1, 2018 Category: Endocrinology Source Type: research

Clinical and genetic characteristics of familial hypercholesterolemia patients with type 2 diabetes
ConclusionsAlthough there were not many differences in the clinical, lipid and genetic aspects of HeFH patients with and without T2DM, T2DM and HbA1c were associated with worse coronary lesions, suggesting that diabetes and the degree of blood glucose control are also important determinants of cardiovascular disease in these patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 1, 2018 Category: Endocrinology Source Type: research

Association between systemic leptin and neurotensin concentration in adult individuals with and without type 2 diabetes mellitus
ConclusionsCirculating leptin is associated with higher proNT levels independent of diabetes, obesity and metabolic syndrome components; besides its effects on central leptin signaling, NT may influence energy balance by modulating circulating leptin concentration likely through a mechanism involving gut fat absorption. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 1, 2018 Category: Endocrinology Source Type: research

Efficacy and safety of long-term management of patients with chronic post-surgical hypoparathyroidism
ConclusionsTreatment of chronic PO-HypoPT with calcium and activated vitamin D metabolites is suboptimal and associated with an increased risk of renal complications. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 1, 2018 Category: Endocrinology Source Type: research

Multiple endocrine neoplasia 2 in Cyprus: evidence for a founder effect
ConclusionsThe mutation p.Cys618Arg is by far the most prevalent mutation in Cyprus followed by other reported mutations of variable clinical significance. The provided molecular evidence speculates p.Cys618Arg mutation as an ancestral mutation that has spread in Cyprus due to a possible founder effect. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 1, 2018 Category: Endocrinology Source Type: research

The psychometric evaluation of the quality of life in short stature youth (QoLISSY) instrument for German children born small for gestational age
ConclusionPsychometric testing suggests that QoLISSY is a promising instrument to assess the HrQoL of young German people with SGA. Both versions (parent- and child report) appear to detect differences between SGA and other conditions (e.g. ISS). QoLISSY can be used in clinical studies, health service research, as well as in practice in children with SGA and their parents. For a cross-cultural application of the instrument in SGA, the tool needs be validated in sufficiently large SGA samples within respective countries. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 1, 2018 Category: Endocrinology Source Type: research

Identification of key genes of papillary thyroid cancer using integrated bioinformatics analysis
ConclusionBCL2,CCND1 andCOL1A1 may be key genes for papillary thyroid carcinoma. Further molecular biological experiments are required to confirm the function of the identified genes. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 1, 2018 Category: Endocrinology Source Type: research

Evaluation of adequacy of levo-thyroxine dosage in patients with differentiated thyroid carcinoma: correlation between morning and afternoon TSH determination
AbstractPurposeThe aim of this study was to judge the reliability of evaluating thyroid-stimulating hormone (TSH) and free thyroxine (f-T4) in the morning and afternoon in differentiated thyroid carcinoma (DTC) patients.MethodsWe evaluated 153 DTC patients, aged 61  ± 13 years, in active follow-up in our center after primary treatments and under stabilized levo-thyroxine (L-T4) posology. In each patient, morning and afternoon examinations were performed 1-3 months apart. Blood samples were collected at 08:00–09:00 h and 15:00–16:00 h. TSH and f-T4 were evaluated in both samp...
Source: Journal of Endocrinological Investigation - October 1, 2018 Category: Endocrinology Source Type: research

Daniel Lambert, a protagonist of real life with monstrous obesity in eighteenth century in England
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 1, 2018 Category: Endocrinology Source Type: research

Adipose insulin resistance is associated with cardiovascular risk factors in polycystic ovary syndrome
AbstractPurposeThe effects of adipose insulin resistance on cardiovascular risk factors in polycystic ovary syndrome (PCOS) remain largely unknown. We aimed to investigate associations between adipose insulin resistance and cardiovascular risk factors in PCOS.MethodsA total of 207 PCOS and 47 non-PCOS women were recruited from a large reproductive medicine center in this cross-sectional study. The PCOS diagnosis was based on the Rotterdam Criteria. The subjects received a standard oral glucose tolerance test. Adipose insulin resistance was evaluated using a validated index (adipose-IR  = fasting insulin&thins...
Source: Journal of Endocrinological Investigation - September 12, 2018 Category: Endocrinology Source Type: research

Usefulness of TSH receptor antibodies as biomarkers for Graves ’ ophthalmopathy: a systematic review
ConclusionWe conclude that the level of TBII may not be a reliable indicator of the current state of GO in pre-treated patients. Whereas, in post-treated patients, due to changes in the correlation between TBII and TSAb due to the effect of hyperthyroidism treatment, the level of TBII can be a more reliable indicator of GO. Furthermore, the current level of TBII is closely associated with the onset and severity of GO in the future and it can be a valid predictor of GO. However, the TSAb level appears to be more reliable. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 7, 2018 Category: Endocrinology Source Type: research

The efficacy of HRAS and CDK4/6 inhibitors in anaplastic thyroid cancer cell lines
AbstractPurposeAnaplastic thyroid carcinomas (ATCs) are non-responsive to multimodal therapy, representing one of the major challenges in thyroid cancer. Previously, our group has shown that genes involved in cell cycle are deregulated in ATCs, and the most common mutations in these tumours occurred in cell proliferation and cell cycle related genes, namelyTP53,RAS,CDKN2A andCDKN2B, making these genes potential targets for ATCs  treatment. Here, we investigated the inhibition of HRAS by tipifarnib (TIP) and cyclinD-cyclin-dependent kinase 4/6 (CDK4/6) by palbociclib (PD), in ATC cells.MethodsATC cell lines, mutated or...
Source: Journal of Endocrinological Investigation - September 6, 2018 Category: Endocrinology Source Type: research

The role of ADAMTS4 and ADAMTS9 in cardiovascular disease in premature ovarian insufficiency and idiopathic hypogonadotropic hypogonadism
AbstractPurposeWe aimed to determine the relation of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS4), and a disintegrin and metalloproteinase with thrombospondin motifs-9 (ADAMTS9) with cardiovascular disease (CVD) risk, in ovarian dysfunction patients with premature ovarian insufficiency (POI), and idiopathic hypogonadotropic hypogonadism (IHH).Methods43 IHH and 44 POI patients were enrolled to this case –control study. Serum hormonal parameters, lipid profiles, ADAMTS4 and ADAMTS9 levels were measured. Lipid accumulation product (LAP) index, visceral adiposity index (VAI), and homeostasis...
Source: Journal of Endocrinological Investigation - September 5, 2018 Category: Endocrinology Source Type: research

Effects of selenium and vitamin C on the serum level of antithyroid peroxidase antibody in patients with autoimmune thyroiditis
ConclusionOur findings supported the hypothesis of antioxidant beneficial effects of Se in AIT. However, it was not superior to vitamin C, regarding its effects on thyroid-specific antibodies. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 4, 2018 Category: Endocrinology Source Type: research

Thyroid nodule recurrence following lobo-isthmectomy: incidence, patient ’s characteristics, and risk factors
ConclusionsThyroid nodules recurrence following lobo-isthmectomy is not a rare event and occurs within 5  years after surgery, more frequently in younger patients with family history of nodular goiter and in women with multiple pregnancies. Pre-surgical TSH levels may predict the development of post-surgical hypothyroidism, possibly improving the management of patients addressed to surgery. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 4, 2018 Category: Endocrinology Source Type: research

Peripheral T and B lymphocytes do not correlate with Graves ’ orbitopathy
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 4, 2018 Category: Endocrinology Source Type: research

Magnetic resonance spectroscopy may serve as a presurgical predictor of somatostatin analog therapy response in patients with growth hormone-secreting pituitary macroadenomas
AbstractPurposeSomatostatin analogs (SSAs) are considered one of the most effective medical treatments for patients with growth hormone-secreting pituitary adenomas (GH-PAs). The postoperative electron microscopy (EM) pathological subtype and SSTR2 expression in the tumor are the most established predictors of patient response to SSA therapy. The aim of this study was to evaluate how will magnetic resonance spectroscopy (MRS) measurements before surgery predict the EM pathological subtypes and SSTR2 expression of tumors, and thereby serve as an indicator for the therapeutic sensitivity to SSAs of patients with GH-PAs.Metho...
Source: Journal of Endocrinological Investigation - August 31, 2018 Category: Endocrinology Source Type: research

Proinflammatory/profibrotic effects of aldosterone in Gitelman ’s syndrome, a human model opposite to hypertension
ConclusionsGS patients seem to be protected by the OxSt status induced by aldosterone and revealed in HS. This human model could provide additional clues to highlight the proinflammatory/cardiovascular remodeling effects of aldosterone. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 22, 2018 Category: Endocrinology Source Type: research

Poverty and immigration as a barrier to iodine intake and maternal adherence to iodine supplementation
ConclusionsBoth Italian and immigrating women with a low income or without access to the public health system have a poor adherence both to the salt iodization policy and to folic acid and iodine supplements in preconception and pregnancy. They also referred a low-frequency intake of iodine-rich-foods. The identification of barriers to health care access could be useful to promote specific health interventions in this target population. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 21, 2018 Category: Endocrinology Source Type: research

Association of OPG –RANKL ratio with left ventricular hypertrophy and geometric remodeling in male overweight/obese youths
ConclusionOPG/RANKL ratio is independently associated with LVH and patterns of LV structural remodeling in male overweight/obese children and adolescents. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 21, 2018 Category: Endocrinology Source Type: research

Genotype –phenotype correlation, gonadal malignancy risk, gender preference, and testosterone/dihydrotestosterone ratio in steroid 5-alpha-reductase type 2 deficiency: a multicenter study from Turkey
ConclusionThere is no significant genotype –phenotype correlation in 5α-RD2. Gonadal malignancy risk seems to be low. If genetic analysis is not available at the time of diagnosis, stimulated T/DHT ratio can be useful, especially if different cut-off values are utilized in accordance with the pubertal status. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 21, 2018 Category: Endocrinology Source Type: research

Serum antibodies against the insulin-like growth factor-1 receptor (IGF-1R) in Graves ’ disease and Graves’ orbitopathy
AbstractBackgroundA role of the insulin-like growth factor-1 receptor (IGF-1R) in the pathogenesis of Graves ’ orbitopathy (GO) has been proposed, but the existence and function of anti-IGF-1R-antibodies (IGF-1R-Abs) are debated.MethodsWe designed a cross-sectional investigation to measure serum IGF-1R-Abs by a commercial assay in consecutive patients with Graves ’ disease (GD) compared with healthy subjects and patients with autoimmune thyroiditis (AT). A total of 134 subjects were screened including 27 healthy subjects, 80 GD patients (54 of whom with GO), and 27 AT patients. The main outcome measure was the ...
Source: Journal of Endocrinological Investigation - August 21, 2018 Category: Endocrinology Source Type: research

Impaired bone matrix glycoprotein pattern is associated with increased cardio-metabolic risk profile in patients with type 2 diabetes mellitus
AbstractPurposeOsteopontin (OPN), osteoprotegerin (OPG) and osteocalcin (OC) are matrix glycoproteins which mediate bone mineralization; moreover, their effects on glucose/insulin homeostasis have recently been demonstrated. Higher circulating OPN and OPG levels have been associated with the presence of insulin resistance, atherosclerosis and coronary heart disease. No data are available on contextual changes of these markers in type 2 diabetes mellitus (T2DM). Therefore, aims of this study were to evaluate serum OPN, OPG and OC levels in T2DM patients and their clinical correlates.MethodsWe recruited 83 consecutive T2DM p...
Source: Journal of Endocrinological Investigation - August 21, 2018 Category: Endocrinology Source Type: research

Correction to: Effects of growth hormone on pregnancy rates of patients with thin endometrium
Unfortunately, there are errors that occurred in the name and manufacture of the growth hormone (GH) received by the patients in the GH group on page two, Table  1 and figure 1 on page three. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 20, 2018 Category: Endocrinology Source Type: research

Effects of mandatory salt iodization on breast milk, urinary iodine concentrations, and thyroid hormones: is iodine deficiency still a continuing problem?
ConclusionsDespite the effective struggle with iodine deficiency and salt iodination control program in Konya, we concluded that iodine deficiency still persists as a significant problem in pregnancies. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 11, 2018 Category: Endocrinology Source Type: research

Effect of cabergoline monotherapy in Cushing ’s disease: an individual participant data meta-analysis
ConclusionsThis meta-analysis shows that cabergoline monotherapy is a reasonable alternative for subjects with persistent or recurrent CD after TSS. It can also be used in CD patients either as a bridge therapy while waiting for surgery or in those unwilling for surgery or have contraindication to it. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 10, 2018 Category: Endocrinology Source Type: research