Relationship between serum cholesterol and Graves ’ orbitopathy (GO): a confirmatory study
ConclusionsOur study confirms a relationship between the presence of GO and cholesterol in patients with GD of recent onset. Whether lowering of cholesterol ameliorates, GO remains to be established. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 19, 2018 Category: Endocrinology Source Type: research

High serum osteopontin levels are associated with prevalent fractures and worse lipid profile in post-menopausal women with type 2 diabetes
ConclusionsIn post-menopausal women with T2DM, OPN might be a useful marker of fracture and worse lipid profile. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 18, 2018 Category: Endocrinology Source Type: research

Peptide receptor radionuclide therapy with 177 Lu-DOTA-TATE as a promising treatment of malignant insulinoma: a series of case reports and literature review
ConclusionsAfter the start of177Lu-DOTA-TATE all patients achieved hypoglycaemia symptomatic control and had evident improvement of their quality of life. Three patients showed imagiological improvement suggesting reduced tumour load. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 9, 2018 Category: Endocrinology Source Type: research

High-dose intravenous methylprednisolone therapy in patients with Graves ’ orbitopathy is associated with the increased activity of factor VIII
AbstractPurposeVenous thromboembolic events (VTE), with their life-threatening manifestation as pulmonary embolism, are potential adverse effects of intravenous methylprednisolone (IVMP) pulse therapy, partially due to a hypercoagulable state. The aim of the study was to analyze the influence of IVMP on selected hemostatic parameters in patients with moderate-to-severe Graves ’ orbitopathy (GO).Methods26 euthyroid patients with GO were treated with 12 pulses of IVMP (6  × 0.5, 6 × 0.25 g every week). Hemostatic variables [factor (F) II, FV, FVII, FVIII, fibrinogen, antithr...
Source: Journal of Endocrinological Investigation - June 9, 2018 Category: Endocrinology Source Type: research

Clinical analysis of cervical lymph node metastasis risk factors in patients with papillary thyroid microcarcinoma
ConclusionsAccording to the clinicopathological characteristics of PTMC, the cervical lymph nodes should be correctly evaluated to guide the surgical treatment. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 6, 2018 Category: Endocrinology Source Type: research

Follow-up of parenchymal changes in the thyroid gland with diffuse autoimmune thyroiditis in children prior to the development of papillary thyroid carcinoma
ConclusionsSonographic follow-up assessments warrant further exploration as a strategy to determine PTC susceptibility in the paediatric population. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 5, 2018 Category: Endocrinology Source Type: research

Advances and controversies in the classification and grading of pituitary tumors
ConclusionsThe 2017 WHO Classification of Pituitary Tumors provides a more solid basis for accurate and reliable prognostic assessment of these lesions. Further progress undoubtedly will be made as the recommendations of this update are incorporated in to routine use. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 1, 2018 Category: Endocrinology Source Type: research

Is elevated urotensin II level a predictor for increased cardiovascular risk in subjects with acromegaly?
ConclusionElevated UII levels are associated with severity of cardiovascular risk factors including cIMT and EFT in acromegalic subjects. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 26, 2018 Category: Endocrinology Source Type: research

A case of drug-induced Graves ’ Orbitopathy after combination therapy with Tremelimumab and Durvalumab
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 26, 2018 Category: Endocrinology Source Type: research

Increased serum interleukin-37 (IL-37) levels correlate with oxidative stress parameters in Hashimoto ’s thyroiditis
AbstractPurpose Interleukin-37 (IL-37), member of the IL-1 family, is a natural suppressor of immune and inflammatory responses. Increased serum IL-37 levels were observed in several autoimmune diseases, including Graves ’ disease. To our knowledge, no data on Hashimoto’s thyroiditis (HT) are available in the literature.Methods Aim of our study was to measure serum IL-37 levels and evaluate their relationship, if any, with oxidative stress markers in HT patients. We enrolled 45 euthyroid HT patients (5 M e 40 F, median age 40  years) and 50 age- and sex-matched healthy controls. None was underl-thyroxi...
Source: Journal of Endocrinological Investigation - May 23, 2018 Category: Endocrinology Source Type: research

Goliath as an acromegalic giant by Giovanni Lanfranco (1582 –1647)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 23, 2018 Category: Endocrinology Source Type: research

Testosterone-mediated activation of androgenic signalling sustains in vitro the transformed and radioresistant phenotype of rhabdomyosarcoma cell lines
ConclusionsOur results suggest that androgens sustain and improve RMS transformed and radioresistant phenotype, and therefore, their therapeutic application should be avoided in RMS post puberal patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 22, 2018 Category: Endocrinology Source Type: research

The association between circulating irisin levels and different phenotypes of polycystic ovary syndrome
ConclusionsCirculating irisin may allow physicians to establish which women merit screening by a biomarker for PCOS. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 21, 2018 Category: Endocrinology Source Type: research

Irisin levels increase after treatment in patients with newly diagnosed Hashimoto thyroiditis
AbstractPurposeIrisin is a newly identified myokine secreted by skeletal muscle and has significant effects on body metabolism. Thyroidal functional state has a profound influence on the metabolism of human body. Therefore, the aim of this study was to investigate the possible changes in serum irisin concentrations before and after treatment in hypothyroid subjects.MethodsThe study included 26 patients with overt hypothyroidism due to Hashimoto thyroiditis and 19 healthy subjects. Baseline serum thyroid function tests and presence of thyroid autoantibodies and levels of creatine kinase (CK) and irisin were measured in both...
Source: Journal of Endocrinological Investigation - May 18, 2018 Category: Endocrinology Source Type: research

Adverse effects of media reports on the treatment of osteoporosis
ConclusionsThere is a gap between the application of clinical recommendations and patient perceptions of osteoporosis and its treatment. There is a need for better education of patients and practitioners aimed at recognizing the serious consequences of fractures and understanding the expected benefits and potential risks of treatment. Media reports that disseminate evidence-based information on the balance of benefits and risks could help to reduce the osteoporosis treatment gap and mitigate the crisis in osteoporosis care. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 14, 2018 Category: Endocrinology Source Type: research

Acromegaly is associated with high fibroblast growth factor-21 levels
ConclusionFGF-21 levels were increased significantly in acromegaly group. Increased FGF-21 levels were significantly and independently associated with the state of acromegaly. Acromegaly may also be a FGF-21 resistance state independent from insulin resistance, glucose intolerance, obesity, hypertension and dyslipidemia. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 12, 2018 Category: Endocrinology Source Type: research

Mechanisms underlying the weight loss effects of RYGB and SG: similar, yet different
AbstractThe worldwide obesity epidemic continues unabated, adversely impacting upon global health and economies. People with severe obesity suffer the greatest adverse health consequences with reduced life expectancy. Currently, bariatric surgery is the most effective treatment for people with severe obesity, resulting in marked sustained weight loss, improved obesity-associated comorbidities and reduced mortality. Sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB), the most common bariatric procedures undertaken globally, engender weight loss and metabolic improvements by mechanisms other than restriction and mal...
Source: Journal of Endocrinological Investigation - May 5, 2018 Category: Endocrinology Source Type: research

Italian consensus on diagnosis and treatment of differentiated thyroid cancer: joint statements of six Italian societies
The objective of this consensus is to inform clinicians, patients, researchers, and health policy makers about the best strategies (and their limitations) relating to the diagnosis and treatment of differentiated thyroid cancer. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 4, 2018 Category: Endocrinology Source Type: research

Can the positive association of osteocalcin with testosterone be unmasked when the preeminent hypothalamic –pituitary regulation of testosterone production is impaired? The model of spinal cord injury
AbstractPurposeOsteocalcin (OCN), released from the bone matrix during the resorption phase, in its undercarboxylated form, stimulates testosterone (T) biosynthesis in mouse and a loss-of-function mutation of its receptor was associated with hypergonadotropic hypogonadism in humans. Nevertheless, when population-based studies have explored the OCN-T association, conflicting results have been reported. Hypothesizing that the evidence of a positive association between OCN and T could have been hindered by the preeminent role of a well-functioning hypothalamus –pituitary axis in promoting T biosynthesis, we explored thi...
Source: Journal of Endocrinological Investigation - May 4, 2018 Category: Endocrinology Source Type: research

“Madonna of the Pinks” and “Madonna Dell’Impannata”: Raphael Sanzio (1483–1520)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 2, 2018 Category: Endocrinology Source Type: research

Diagnosis and treatment of lipodystrophy: a step-by-step approach
ConclusionsHere, we describe the clinical presentation of known types of lipodystrophy, present an algorithm for differential diagnosis of lipodystrophy, and suggest specific steps to recognize and diagnose lipodystrophy in the clinical setting. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 27, 2018 Category: Endocrinology Source Type: research

Dissonance among treatment algorithms for hyperglycemia in type 2 diabetes: an egalitarian dialog
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 27, 2018 Category: Endocrinology Source Type: research

The mutational analysis in the diagnostic work-up of thyroid nodules: the real impact in a center with large experience in thyroid cytopathology
ConclusionsOur study established mutational rates forBRAF andRAS genes in a large series of FNA specimens.BRAF mutations were confirmed as highly specific but not able to improve cytological diagnosis, whileRAS testing proved effective in assessing malignancy in nodules with indeterminate and benign cytology. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 27, 2018 Category: Endocrinology Source Type: research

Adipokine levels in overweight women with early-onset gestational diabetes mellitus
AbstractPurposeThe study of adipokines in overweight women with early-onset (diagnosed before 20  weeks) gestational diabetes mellitus (GDM) could help to understand the ethiopathological mechanisms of this disorder. Our aim was to assess adipokine levels in overweight pregnant women with early-onset GDM compared to patients with standard-onset (diagnosed at 24–28 weeks) GDM and to glucose- tolerant women at the same gestational ages.MethodsThis nested case –control study included 133 overweight pregnant women: 33 with early-onset (diagnosed 
Source: Journal of Endocrinological Investigation - April 25, 2018 Category: Endocrinology Source Type: research

Phosphoproteome profiling revealed abnormally phosphorylated AMPK and ATF2 involved in glucose metabolism and tumorigenesis of GH-PAs
ConclusionThese findings suggest that decreased phosphorylation of the AMPK/ATF2 pathway may be critical for glucose metabolism and tumorigenesis in GH-PAs. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 24, 2018 Category: Endocrinology Source Type: research

mRECIST criteria to assess recurrent thyroid carcinoma treatment response after radiofrequency ablation: a prospective study
ConclusionRFA is a safe procedure to treat the viable tumour tissue and to reduce the RTC volume; as to the criteria to assess treatment response, mRECIST appears to be more accurate. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 23, 2018 Category: Endocrinology Source Type: research

Elevation of isoprostanes in polycystic ovary syndrome and its relationship with cardiovascular risk factors
AbstractPurposeTo evaluate the plasma level of 8-isoprostanes in women with polycystic ovary syndrome. To also investigate whether there is a relationship between 8-isoprostanes and several cardiovascular risk factors.MethodsA total of 125 women with polycystic ovary syndrome and 169 healthy women were enrolled in this case –control study. 8-Isoprostanes and different parameters were measured in all subjects. Patients were evaluated for the presence of polycystic ovary syndrome according to the Rotterdam Consensus Conference criteria.Results8-Isoprostanes levels were significantly higher in patients with polycystic o...
Source: Journal of Endocrinological Investigation - April 23, 2018 Category: Endocrinology Source Type: research

Increased fibulin-1 plasma levels in polycystic ovary syndrome (PCOS) patients: possible contribution to the link between PCOS and cardiovascular risk
ConclusionsOur data could contribute to explain the hypothesized increased cardiovascular risk and vascular damage in patients with PCOS. A better understanding of the cellular and molecular mechanisms involved in cardiometabolic disorders associated with PCOS is mandatory to identify new therapeutic strategies to eventually prevent the progression of cardiovascular diseases in these patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 21, 2018 Category: Endocrinology Source Type: research

Effects of growth hormone on pregnancy rates of patients with thin endometrium
AbstractPurposeTo investigate whether growth hormone (GH) could improve pregnancy rates of patients with thin endometrium by clinical study and laboratory experiments.Materials and methodsNinety-three patients were randomized to either the GH-received group (40) or the routine exogenous administration of estrogens control group (53) for clinical study. The human endometrial carcinoma cell line RL95-2 was used for testing the role of GH with Western blot and real-time PCR by exposure to various concentrations of GH (0.1 nM,1 nM,10 nM,100 nM).ResultsPatients treated with GH had a significantly (P 
Source: Journal of Endocrinological Investigation - April 18, 2018 Category: Endocrinology Source Type: research

Lack of association between obesity and aggressiveness of differentiated thyroid cancer
ConclusionsObesity was not associated with aggressive features in this prospective, European cohort of patients with DTC. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 17, 2018 Category: Endocrinology Source Type: research

Adrenocortical carcinoma: the dawn of a new era of genomic and molecular biology analysis
AbstractOver the last decade, the development of novel and high penetrance genomic approaches to analyze biological samples has provided very new insights in the comprehension of the molecular biology and genetics of tumors. The use of these techniques, consisting of exome sequencing, transcriptome, miRNome, chromosome alteration, genome, and epigenome analysis, has also been successfully applied to adrenocortical carcinoma (ACC). In fact, the analysis of large cohorts of patients allowed the stratification of ACC with different patterns of molecular alterations, associated with different outcomes, thus providing a novel m...
Source: Journal of Endocrinological Investigation - April 16, 2018 Category: Endocrinology Source Type: research

Decreased staging of differentiated thyroid cancer in patients with chronic lymphocytic thyroiditis
AbstractPurposeThe biological association between chronic lymphocytic thyroiditis (CLT) and differentiated thyroid cancer (DTC) has not been elucidated yet. The aim of the study was to assess whether the presence of CLT exerts any influence on clinical or histological presentation of DTC.MethodsNine hundred and seven consecutive patients with DTC treated in the years 1998 –2016 were divided into two groups according to the presence or absence of concomitant CLT. The statistical differences were analysed.ResultsOut of 907 patients included in the study, 331 were diagnosed with DTC and CLT (studied group), while 576 pa...
Source: Journal of Endocrinological Investigation - April 4, 2018 Category: Endocrinology Source Type: research

Clinical presentation and management of patients with primary hyperparathyroidism in Italy
AbstractPurposeEvaluation of the phenotype of primary hyperparathyroidism (PHPT), adherence to International Guidelines for parathyroidectomy (PTx), and rate of surgical cure.MethodFrom January 2014 –January 2016, we performed a prospective, multicenter study in patients with newly diagnosed PHPT. Biochemical and instrumental data were collected at baseline and during 1-year follow-up.ResultsOver the first year we enrolled 604 patients (age 61  ± 14 years), mostly women (83%), referred for further evaluation and treatment advice. Five hundred sixty-six patients had sporadic PHPT (93.7%, age ...
Source: Journal of Endocrinological Investigation - April 3, 2018 Category: Endocrinology Source Type: research

Correction to: Radioiodine ablation with 1,850 MBq in association with rhTSH in patients with differentiated thyroid cancer
AbstractUnfortunately, the fourth author ’s middle name was missed out in the original publication of this article. The complete correct name should read as follows. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 2, 2018 Category: Endocrinology Source Type: research

DNA methylation of genes regulating appetite and prediction of weight loss after bariatric surgery in obese individuals
AbstractPurposeEpigenetic traits are influenced by clinical variables; interaction between DNA methylation (DNAmeth) and bariatric surgery-induced weight loss has been scarcely explored. We investigated whether DNAmeth of genes encoding for molecules/hormones regulating appetite, food intake or obesity could predict successful weight outcome following Roux-en-Y gastric bypass (RYGB).MethodsForty-five obese individuals with no known comorbidities were stratified accordingly to weight decrease one-year after RYGB (excess weight loss, EWL  ≥ 50%: good responders, GR; EWL 
Source: Journal of Endocrinological Investigation - March 30, 2018 Category: Endocrinology Source Type: research

TSH evaluation in hypothyroid patients assuming liquid levothyroxine at breakfast or 30  min before breakfast
ConclusionsThis study confirms in a large set of patients that a liquid LT4 formulation can be taken directly at breakfast and potentially improve therapeutic compliance. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 26, 2018 Category: Endocrinology Source Type: research

Gabriella Morreale de Escobar (1930 –2017)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 26, 2018 Category: Endocrinology Source Type: research

MicroRNA expression profile of thyroid nodules in fine-needle aspiration cytology: a confirmatory series
ConclusionIn this study, we confirmed that a limited set of miRNAs can be used for the differential diagnosis of thyroid nodules. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 24, 2018 Category: Endocrinology Source Type: research

Predictors of fat-free mass loss 1  year after laparoscopic sleeve gastrectomy
AbstractPurposeLaparoscopic sleeve gastrectomy (LSG) is one of the most frequently performed bariatric surgery interventions because of its safety and efficacy. Nevertheless, concerns have been raised on its detrimental effect on patient nutritional state that can ultimately lead to the loss of fat-free mass (FFM). There is interest in identifying predictors for the early identification of patients at risk of this highly unwanted adverse because they could benefit of nutritional preventive interventions. Therefore, we investigated whether anthropometric parameters, body composition or resting energy expenditure (REE) measu...
Source: Journal of Endocrinological Investigation - March 24, 2018 Category: Endocrinology Source Type: research

Oxysterol species: reliable markers of oxidative stress in diabetes mellitus
AbstractPurposeTo assess the plasma oxysterol species 7-ketocholesterol (7-Kchol) and cholestane-3 β,5α,6β-triol (chol-triol) as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus (DM).MethodsIn total, 26 type 1 and 80 type 2 diabetes patients, along with 205 age- and gender-matched healthy controls, were included in this study. Oxysterols were quantified by liquid chromatography coupled with tandem mass spectrometry andN,N-dimethylglycine derivatization. Correlations between oxysterols and clinical/biochemical characteristics of the diabetes patients, and factors affecting 7-Kchol and ch...
Source: Journal of Endocrinological Investigation - March 21, 2018 Category: Endocrinology Source Type: research

Investigating the effect of testosterone by itself and in combination with letrozole on 1,25-dihydroxy vitamin D and FGF23 in male rats
AbstractBackgroundTestosterone deficiency might be associated with vitamin D levels in hypogonadal men, but it is not clear whether testosterone can affect vitamin D and fibroblast growth factor-23 (FGF23), either directly or indirectly via aromatization to estradiol. We aimed to investigate the role of testosterone on vitamin D metabolism and serum FGF23 in male rats.MethodsA total of 48 male rats were divided into 4 equal groups: sham; O, orchiectomy; O  + T, orchiectomized rats treated with testosterone; and O + T + L, orchiectomized rats treated with combination of testosterone and...
Source: Journal of Endocrinological Investigation - March 20, 2018 Category: Endocrinology Source Type: research

Joseph Boruwlaski: the last court dwarf of the History
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 20, 2018 Category: Endocrinology Source Type: research

Clinicopathologic risk factors for right paraesophageal lymph node metastasis in patients with papillary thyroid carcinoma
ConclusionsLymph node dissection, including RPELN dissection, should be performed for patients with PTC with a tumor diameter  ≥ 1 cm, multiple tumors, right-lobe tumors, right central compartment lymph node metastasis, or suspected lateral compartment lymph node metastasis. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 17, 2018 Category: Endocrinology Source Type: research

Specificity of late-night salivary cortisol measured by automated electrochemiluminescence immunoassay for Cushing ’s disease in an obese population
AbstractPurposeData about the specificity of late-night salivary cortisol (LNSC) in obese subjects are still conflicting. Therefore, with this study, we aimed to evaluate the specificity of LNSC measurement in an obese cohort with or without type 2 diabetes mellitus (T2DM) using an automated electrochemiluminescence immunoassay (ECLIA).MethodsA total number of 157 patients involving 40 healthy subjects (HS) with BMI  
Source: Journal of Endocrinological Investigation - March 17, 2018 Category: Endocrinology Source Type: research

From inflammation to sexual dysfunctions: a journey through diabetes, obesity, and metabolic syndrome
AbstractMetabolic diseases are associated with chronic low-grade inflammation, which has been indicated as a potential mediator of endothelial dysfunction and cardiovascular disease. Visceral adiposity is thought to be the starting condition of the inflammatory state through the release of inflammatory cytokines, including TNF-alpha, CRP, and IL-6, which in turn promote endothelial dysfunction, endothelial expression of chemokines (IL-1) and adhesion molecules (ICAM-1, VCAM-1, and P-selectin), and the inhibition of anti-atherogenic factors (adiponectin). Obesity, metabolic diseases, and diabetes, all conditions characteriz...
Source: Journal of Endocrinological Investigation - March 16, 2018 Category: Endocrinology Source Type: research

Combined BRAF V600E analysis and 99m Tc-MIBI scintigraphy can be a useful diagnostic tool in differentiated thyroid cancer patients with incomplete bio-chemical response to first radioiodine therapy (RAIT): a pilot investigation
ConclusionAlbeit obtained in a small retrospective series, our results suggest that the combination of BRAFV600E+ve mutation and MIBI −ve scintigraphy may be considered a negative prognostic clue, which predicts the absence of radioiodine uptake at pT-WBS in DTC patients with incomplete bio-chemical response to first RAIT. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 16, 2018 Category: Endocrinology Source Type: research

Lymph node location is a risk factor for papillary thyroid cancer-related death
ConclusionsThe presence of lymph node metastases in the N1b compartment should be considered as a risk factor for distant metastatic spread and for cancer-related death and included in post-surgery evaluation. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 16, 2018 Category: Endocrinology Source Type: research

Association of PON1 gene polymorphisms with polycystic ovarian syndrome risk: a meta-analysis of case –control studies
ConclusionsOur study has shown thatPON1− 108 C/T polymorphism might be associated with increased risk of PCOS under the allelic, homozygote, heterozygote, and dominant models. Additionally,PON1 192 Q/R and L55M polymorphisms were significantly related only in the allelic and recessive model, and in the heterozygote and dominant model, respectively. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 15, 2018 Category: Endocrinology Source Type: research

The AMPK-activator AICAR in thyroid cancer: effects on CXCL8 secretion and on CXCL8-induced neoplastic cell migration
AbstractPurposeThe AMPK-activator AICAR recently raised great interest for its anti-cancer properties. With specific regard to thyroid cancer, AICAR reduces cancer cell growth, invasion and metastasis. CXCL8, a chemokine with several recognized tumorigenic effects, is abundantly secreted in thyroid cancer microenvironment. The aim of this study was to investigate if AICAR could inhibit the basal and the TNF α-induced CXCL8 secretion in normal human thyroid cells (NHT) and in thyroid cancer cell lines TPC-1 and BCPAP (RET/PTC and BRAFV600e mutated, respectively).MethodsThe effect of AICAR on basal and CXCL8-induced ce...
Source: Journal of Endocrinological Investigation - March 15, 2018 Category: Endocrinology Source Type: research

Clinical impact of the new SIAPEC-IAP classification on the indeterminate category of thyroid nodules
ConclusionsThis analysis shows that the new SIAPEC-IAC criteria significantly increased the proportion of the overall TIR3 diagnosis. The division of TIR3 nodules into two subgroups (A and B) allowed a better evaluation of the oncologic risk and a better selection of patients to be referred to surgery. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 15, 2018 Category: Endocrinology Source Type: research