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Psychological symptoms and brain activity alterations in women with PCOS and their relation to the reduced quality of life: a narrative review
ConclusionsSeveral factors can negatively influence the quality of life of the patients, and they are directly related to hyperandrogenism and the risk of infertility. In particular, obesity, hirsutism, acne, and the fear of infertility can have a direct impact on self-esteem and sexual function. Metabolic and psychiatric comorbidities, such as mood, anxiety, and eating disorders, can affect the well-being of the patients. Moreover, specific cognitive alteration s, such as impairments in attention and memory, can limit PCOS patients in a series of aspects of daily life. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 15, 2024 Category: Endocrinology Source Type: research

Temporal trends in the clinical presentation of Graves ’ orbitopathy: a single–center retrospective study
ConclusionsWe found that GO severity at presentation was significantly reduced over a ten-year observation period (2005 –2006 vs. 2015–2016) in GO patients referred to our tertiary thyroid centre. TGOD ≥ 3 months was an independent predictor of GO severity. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 15, 2024 Category: Endocrinology Source Type: research

Diagnosis and treatment of Paget ’s disease of bone: position paper from the Italian Society of Osteoporosis, Mineral Metabolism and Skeletal Diseases (SIOMMMS)
AbstractIntroductionPaget ’s disease of bone is a focal skeletal disorder causing bone deformities and impairing bone quality. Despite the prevalence of asymptomatic cases is increasing, the progression of the disease can lead to invalidating complications that compromise the quality of life. Doubts on clinical and therape utic management aspects exist, although beneficial effects of antiresorptive drugs, particularly bisphosphonates are known. However, limited information is available from randomized controlled trials on the prevention of disease complications so that somewhat contrasting positions about treatment in di...
Source: Journal of Endocrinological Investigation - March 15, 2024 Category: Endocrinology Source Type: research

CircNRCAM up-regulates NRCAM to promote papillary thyroid carcinoma progression
ConclusionIn summary, circNRCAM could up-regulate NRCAM by down-regulating miR-506-3p, thereby enhancing the biological behaviors of PTC cells. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 14, 2024 Category: Endocrinology Source Type: research

Hsa_circ_0008360 promotes high glucose-induced damage in HK-2 cells via miR-346/WNT2B axis
ConclusionHsa_circ_0008360 can regulate miR-346/WNT2B axis in HG-induced HK2 cells, providing an underlying targeted therapy for DN patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 12, 2024 Category: Endocrinology Source Type: research

Once upon a time: the glucagon stimulation test in diagnosing adult GH deficiency
ConclusionThis document provides an update on the utility of GST, summarizes how to perform the test, shows which cut-points should be used in interpreting the results, and discusses its drawbacks and caveats referring to the most recent studies. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 10, 2024 Category: Endocrinology Source Type: research

Enhancing gestational diabetes mellitus risk assessment and treatment through GDMPredictor: a machine learning approach
ConclusionsThe GDMPredictor presents a valuable asset for clinical practice, with the potential to change the management of GDM in pregnant women. Its high accuracy and efficiency make it a reliable tool for doctors to improve patient outcomes. Early identification of high-risk individuals and tailored treatment can improve maternal and fetal health outcomeshttp://www.bioinfogenetics.info/GDM/. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 9, 2024 Category: Endocrinology Source Type: research

Adipokine secretion and lipolysis following gender-affirming treatment in transgender individuals
ConclusionIn TW, gonadal hormone suppression results in transient changes in cytokines and in TM there are some changes in NA-stimulated lipolysis following testosterone treatment. However, despite the known metabolic effects of sex hormones, the overall effects of GAHT on adipose tissue function are small and likely have limited clinical relevance, but larger studies with longer follow-up are needed to confirm these findings.Trial registrationClinicalTrials.gov Identifier: NCT02518009, Retrospectively registered 7 August 2015. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 9, 2024 Category: Endocrinology Source Type: research

Thyroiditis and COVID-19: focus on pediatric age. A narrative review
ConclusionHowever, due to the limited evidence available, further prospective longitudinal studies are required to clarify the relationship between COVID-19 and thyroid disease in children and adolescents, as well as to investigate any potential long-term consequences. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 8, 2024 Category: Endocrinology Source Type: research

Vitamin D and risk of developing type 2 diabetes in the SUN project: a prospective cohort study
ConclusionThe outcomes suggest that higher levels of vitamin D at baseline may be associated with a reduced risk of developing T2D. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 8, 2024 Category: Endocrinology Source Type: research