Presence of diabetes-specific autoimmunity in women with gestational diabetes mellitus (GDM) predicts impaired glucose regulation at follow-up
AbstractPurposeGestational diabetes mellitus (GDM) is the most frequent complication of pregnancy; around 10% of GDM cases may be determined by autoimmunity, and our aims were to establish the role of autoimmunity in a population of Sardinian women affected by GDM, to find predictive factors for autoimmune GDM, and to determine type 1 diabetes (T1D) auto-antibodies (Aabs) together with glucose tolerance after a mean 21.2  months of follow-up.MethodsWe consecutively recruited 143 women affected by GDM and 60 without GDM; clinical data and pregnancy outcomes were obtained by outpatient visit or phone recall. T1D auto-an...
Source: Journal of Endocrinological Investigation - January 16, 2018 Category: Endocrinology Source Type: research

A novel splice site mutation of the PRKAR1A gene, C.440+5 G & gt;C, in a Chinese family with Carney complex
ConclusionIn conclusion, the c.440+5 G>C mutation is a new splice site mutation that has not been reported and has the potential to broaden the mutational spectrum ofPRKAR1A that is associated with CNC, which would facilitate genetic diagnosis and counseling for CNC. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 9, 2018 Category: Endocrinology Source Type: research

Long-term response to recombinant human growth hormone treatment: a new predictive mathematical method
ConclusionsIn conclusion, the large and accurate database of Italian GHD patients allowed us to assess the rhGH treatment efficacy and compare the results with those obtained in other Countries. Moreover, we proposed and validated a new mathematical model forecasting the expected final height after therapy which was validated on our cohort. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 9, 2018 Category: Endocrinology Source Type: research

Endocrinological aspects of HIV infection
ConclusionsClinicians need to have a high index of suspicion for endocrine abnormalities in people with HIV as they can be potentially life threatening if untreated. Endocrine evaluation should be pursued as in the general population, with focus on prevention, early detection and treatment to improve quality of life and longevity. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 8, 2018 Category: Endocrinology Source Type: research

Edmonton obesity staging system among pediatric patients: a validation and obesogenic risk factor analysis
ConclusionsFew outpatients were healthy obese (stage 0), while the majority exhibited several comorbidities. Since each obesity tier entails different impacts to disease management, the study herein highlights modifiable factors facilitating descend to lower stages, and provides insight for designing tailored approaches tackling the high national pediatric obesity rates. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 8, 2018 Category: Endocrinology Source Type: research

Hepcidin, soluble transferrin receptor and IL-6 levels in obese children and adolescents with and without type 2 diabetes mellitus/impaired glucose tolerance and their association with obstructive sleep apnea
ConclusionsHigher IL-6 levels were associated with both glycemic status and OSA. No differences in body iron regulator levels were found in obese patients with T2DM/IGT compared to those without or in those with OSA compared to those without. Further longitudinal studies in larger population samples are warranted. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 5, 2018 Category: Endocrinology Source Type: research

A balanced reciprocal translocation t(10;15)(q22.3;q26.1) interrupting ACAN gene in a family with proportionate short stature
ConclusionsThis is the first description of a chromosome rearrangement disruptingACAN and leading to its haploinsufficiency.ACAN loss of function should be considered a potential underpinning of short patients who display a poor growth spurt and belong to families with autosomal dominant segregation of proportionate short stature. Besides this core phenotype, literature review suggests that advanced bone age, early onset osteochondritis dissecans, osteoarthritis, intervertebral disc disease as well as craniofacial dysmorphisms can be important suggestive phenotypes in affected families. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 4, 2018 Category: Endocrinology Source Type: research

Intensified blood glucose treatment in diabetic patients undergoing a liver transplant: impact on graft evolution at 3  months and at 5 years
ConclusionsOur study shows a decrease in the rate of liver graft rejection in diabetic patients undergoing intensive insulin treatment. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 30, 2017 Category: Endocrinology Source Type: research

Hyperhomocysteinemia in acute iatrogenic hypothyroidism: the relevance of thyroid autoimmunity
AbstractPurposeHyperhomocysteinemia is a known cardiovascular risk factor and a key player in the inflammatory activation of autoimmune diseases. Hashimoto ’s thyroiditis (HT) is the leading cause of hypothyroidism which, in itself, has been associated with a significant raise of homocysteine (Hcy) levels and increased cardiovascular risk. Our aim was to assess the impact of HT on Hcy levels in patients with acute hypothyroidism.MethodsWe prospectively enrolled 121 patients (mean age: 46  years, F/M = 102/19) with acute post-surgical hypothyroidism. Based on the presence of anti-thyroid antibodies and ...
Source: Journal of Endocrinological Investigation - December 29, 2017 Category: Endocrinology Source Type: research

Thanks to Reviewers 2017
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 28, 2017 Category: Endocrinology Source Type: research

Correction to: Pegvisomant in acromegaly: an update
AbstractUnfortunately, in page 584, second column, the first sentence under the heading “Type of switch” has been published incorrectly. The complete correct sentence is given below. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 28, 2017 Category: Endocrinology Source Type: research

Happy Birthday, Journal of Endocrinological Investigation!
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 20, 2017 Category: Endocrinology Source Type: research

Antioxidant effects of β-carotene, but not of retinol and vitamin E, in orbital fibroblasts from patients with Graves’ orbitopathy (GO)
ConclusionsOur study supports an antioxidant role of retinol, β-carotene, and vitamin E in orbital fibroblasts from patients with GO and provides a basis for a possible clinical use these substances. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 18, 2017 Category: Endocrinology Source Type: research

One-hour post-load plasma glucose level is associated with a worse metabolic profile in children with GH deficiency
AbstractPurposeIn children, the plasma glucose value at 1 h (1hPG) during OGTT higher than 132.5  mg/dl is a predictor of alterations in glucose metabolism. We aimed to metabolically characterize GHD children according to 1hPG levels.MethodsFifty-one GHD children (35  M, 16 F; mean age 8.6 years), grouped according to 1hPG, were evaluated at diagnosis and after 12 months of GH treatment (GHT) and compared with 50 matched controls at baseline. Auxological parameters, insulin-like growth factor-1 (IGF-1), glucose and insulin during OGTT, lipid profile, the oral disposition index (DIo), the homeostasis m...
Source: Journal of Endocrinological Investigation - December 16, 2017 Category: Endocrinology Source Type: research

Molecular study of human sperm RNA: Ropporin and CABYR in asthenozoospermia
ConclusionsThe results demonstrated downregulation of both ROPN1 and CABYR in asthenozoospermic samples and importantly, a positive correlation between the expression of the two genes, suggesting that ROPN1 and CABYR co-expression is a prerequisite for normal flagellar function and sperm motility. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 15, 2017 Category: Endocrinology Source Type: research

Transoral thyroidectomy: a viable surgical option with unprecedented complications —a case series
ConclusionPatients strongly motivated to undergo a novel surgical procedure tailored to their needs and desires should be properly counselled particularly regarding unconventional procedure-related complications. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 14, 2017 Category: Endocrinology Source Type: research

Thyroid dysfunctions secondary to cancer immunotherapy
ConclusionsCancer patients treated with monoclonal antibodies that block immune checkpoint inhibitors are at risk of developing thyroid dysfunctions. Their thyroid status should be assessed at baseline and periodically after initiation of the immunotherapy. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 13, 2017 Category: Endocrinology Source Type: research

Copeptin and insulin resistance: effect modification by age and 11 β-HSD2 activity in a population-based study
AbstractPurposeArginine vasopressin (AVP) may be involved in metabolic syndrome (MetS) by altering liver glycogenolysis, insulin and glucagon secretion, and pituitary ACTH release. Moreover, AVP stimulates the expression of 11 β-hydroxysteroid-dehydrogenase-type 2 (11β-HSD2) in mineralocorticosteroid cells. We explored whether apparent 11β-HSD2 activity, estimated using urinary cortisol-to-cortisone ratio, modulates the association between plasma copeptin, as AVP surrogate, and insulin resistance/MetS in the general ad ult population.MethodsThis was a multicentric, family-based, cross-sectional sample of 108...
Source: Journal of Endocrinological Investigation - December 12, 2017 Category: Endocrinology Source Type: research

Age-specific reference values and cut-off points for anti-m üllerian hormone in infertile women following a long agonist treatment protocol for IVF
ConclusionsDetermining AMH reference values in IVF candidates allows specialists to measure only AMH plasma levels in IVF candidates so as to find whether or not the ovarian response is normal before applying other therapeutic measures; accordingly, they can adjust a treatment plan for each individual separately. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 12, 2017 Category: Endocrinology Source Type: research

Chronic lymphocytic thyroiditis (CLT) has a positive prognostic value in papillary thyroid cancer (PTC) patients: the potential key role of Foxp3+  T lymphocytes
ConclusionsOur data suggest that concurrent CLT has a protective effect on PTC outcome and that the imbalance between cytotoxic and regulatory T lymphocytes in the peri-tumoral TAL may affect the tumor-specific immune response favoring a more aggressive behavior of cancer. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 11, 2017 Category: Endocrinology Source Type: research

Efficacy and tolerability of a spray formulation containing Visnadine in women self-reporting sexual symptoms: a randomized double-blind placebo-controlled pilot study
AbstractPurposeThe aim of this pilot, double-blind, randomized, placebo-controlled study, was to evaluate both the efficacy and the tolerability of a formulation for vulvar application containing Visnadine, a natural extractive substance with vasoactive properties, (ReFeel® spray, IDI Integratori Dietetici Italiani S.r.l., Italy) in women self-reporting sexual symptoms.MethodsSixty women (age range 18 –60 years) volunteered to test the product against placebo (PL): Two puffs in the vulvar area, 10 min before sexual stimulation, for 30 days and for a minimum of six times. The main outcome measure wa...
Source: Journal of Endocrinological Investigation - December 11, 2017 Category: Endocrinology Source Type: research

Pituitary adenomas, stem cells, and cancer stem cells: what ’s new?
ConclusionsAs in other benign and malignant tumors, the hypothesis that CSCs play a pivotal role in pituitary adenoma onset has been confirmed as well as the existence of a link between the epithelial-to-mesenchymal transition (EMT) process and CSC formation in epithelial tumors. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 8, 2017 Category: Endocrinology Source Type: research

RNASEH1 gene variants are associated with autoimmune type 1 diabetes in Colombia
ConclusionIn conclusion, our analyses suggest thatRNASEH1 gene variants associate with susceptibility/protection to T1D in Colombia. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 4, 2017 Category: Endocrinology Source Type: research

NAFLD/NASH in patients with type 2 diabetes and related treatment options
AbstractType 2 diabetes may reduce life expectancy and patients ’ quality of life due to its micro- and macro-vascular complications and to the higher risk of several types of cancer. An emerging important factor is represented by the hepatic involvement; it is recognized that excessive hepatic fat accumulation represents a typical feature of diabetic patients and that it also plays an important pathogenic role. It is now evident that non-alcoholic fatty liver disease (NAFLD), generally perceived as a benign condition, may have on the contrary an important deleterious impact for diabetic patients increasing the risk ...
Source: Journal of Endocrinological Investigation - November 30, 2017 Category: Endocrinology Source Type: research

A genome-wide DNA methylation analysis in peripheral blood from patients identifies risk loci associated with Graves ’ orbitopathy
AbstractObjectiveGraves ’ orbitopathy (GO) is an inflammatory orbital disease of autoimmune origin with the potential to cause severe functional and psychosocial effects. The pathogenesis has not been fully elucidated. We investigated whether DNA methylation was associated with GO incidence in Chinese patients.Materials and methodsSix GO patients and six age-matched controls were recruited, and genome-wide DNA methylation patterns were analyzed in their peripheral blood.t tests were performed to determine differential methylated sites in genomic regions and the univariable logistic regression analyses was performed t...
Source: Journal of Endocrinological Investigation - November 30, 2017 Category: Endocrinology Source Type: research

Impaired taste sensation in type 2 diabetic patients without chronic complications: a case –control study
ConclusionsTaste recognition thresholds were higher in uncomplicated T2DM, and central obesity was significantly associated with this impairment. Hypogeusia may be an early sign of diabetic neuropathy and be implicated in the poor compliance of these patients to dietary recommendations. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 28, 2017 Category: Endocrinology Source Type: research

The effect of hypergastrinemia following sleeve gastrectomy and pantoprazole on type 2 diabetes mellitus and beta-cell mass in Goto-Kakizaki rats
AbstractPurposeMetabolic surgery alters the secretion of gastrointestinal hormones that influence glycemic control. Elevated gastrin has been suggested to benefit patients with type 2 diabetes and has been reported following sleeve gastrectomy in rats. The present study compares the effect of hypergastrinemia following sleeve gastrectomy with proton-pump inhibitor therapy on glycemic control and beta-cell mass in lean, diabetic animals.MethodsThirty-three diabetic Goto-Kakizaki rats were randomized into pantoprazole  + sham operation (GK-PPI), sleeve gastrectomy (GK-SG) and vehicle + sham operation (GK-...
Source: Journal of Endocrinological Investigation - November 22, 2017 Category: Endocrinology Source Type: research

High-resolution melting analysis (HRM) for mutational screening of Dnajc17 gene in patients affected by thyroid dysgenesis
ConclusionsDNAJC17 mutations are not frequently present in patients with TD. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 20, 2017 Category: Endocrinology Source Type: research

Approach to hyponatremia according to the clinical setting: Consensus statement from the Italian Society of Endocrinology (SIE), Italian Society of Nephrology (SIN), and Italian Association of Medical Oncology (AIOM)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 20, 2017 Category: Endocrinology Source Type: research

Predictability of hypoadrenalism occurrence and duration after adrenalectomy for ACTH-independent hypercortisolism
AbstractObjectiveTo evaluate if the parameters of hypothalamic –pituitary–adrenal (HPA) axis activity could predict the occurrence and duration of post-surgical hypocortisolism (PSH) in patients with Cushing’s syndrome (CS) and with adrenal incidentaloma (AI).MethodsWe studied 80 patients (54 females, age 53.3  ± 11 years), who underwent adrenalectomy for CS (17 patients) or for AI (53 patients). Before surgery, we measured adrenocorticotroph hormone (ACTH), urinary free cortisol (UFC) and serum cortisol after 1 mg dexamethasone suppression test (1 mg-DST) levels. After sur...
Source: Journal of Endocrinological Investigation - November 18, 2017 Category: Endocrinology Source Type: research

Increased serum 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) levels are associated with glucose metabolism in Chinese pregnant women
ConclusionsElevated serum CMPF levels are detrimental to the development of hyperglycemia and islet β-cell functional failure in patients with GDM, which may promote the development of GDM. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 18, 2017 Category: Endocrinology Source Type: research

Impact of risk factors for gestational diabetes (GDM) on pregnancy outcomes in women with GDM
In this study, we evaluated the impact of risk factors for gestational diabetes on clinical/biochemical parameters and maternal/fetal outcomes.MethodsOne hundred eighty-three (n 183) women (age 33.8  ± 5.5 years, 59% Caucasians, 41% non-Caucasians) with gestational diabetes were included in the study. Anamnestic information, anthropometric and laboratory parameters, and maternal and fetal outcomes at delivery were collected.ResultsInsulin therapy prevalence was higher in Asians vs Caucasians (p = 0.006), despite lower pre-pregnancy BMI in Asians (p = 0.0001) and in pre-pregnancy ov...
Source: Journal of Endocrinological Investigation - November 17, 2017 Category: Endocrinology Source Type: research

Impact of perfluorochemicals on human health and reproduction: a male ’s perspective
AbstractPerfluoroalkyl compounds (PFCs) are a class of organic molecules used in industry and consumer products. PFCs are non-biodegradable and bioaccumulate in the environment and for these reasons they have been a major subject of research regarding their toxicity, environmental fate, and sources of human exposure, since they have been shown to induce severe health consequences, such as neonatal mortality, neurotoxicity and immunotoxicity. The aim of this review is to explore the existing knowledge of the interplay between PFCs exposure and human health, with a focus on male reproductive health, given the emerging gender...
Source: Journal of Endocrinological Investigation - November 17, 2017 Category: Endocrinology Source Type: research

Gemigliptin, a novel dipeptidyl peptidase-IV inhibitor, exerts a synergistic cytotoxicity with the histone deacetylase inhibitor PXD101 in thyroid carcinoma cells
ConclusionsOur results demonstrate that gemigliptin induces cytotoxicity in thyroid carcinoma cells. Moreover, gemigliptin has a synergistic activity with PXD101 in the induction of cell death through involvement of Bcl2 family proteins, xIAP and survivin as well as mediation of Akt and AMPK in thyroid carcinoma cells. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 16, 2017 Category: Endocrinology Source Type: research

Expression of p27 Kip1 and p18 Ink4c in human multiple endocrine neoplasia type 1-related pancreatic neuroendocrine tumors
Conclusions These findings indicate that loss of p18Ink4c, but not p27Kip1, is a common event in the development of MEN1-related PanNETs. Restoration of p18Ink4c function through CDK4/6 inhibitors could be a therapeutic option for MEN1-related PanNETs. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 13, 2017 Category: Endocrinology Source Type: research

Innovative clinical pathways for obese pregnant women: design and feasibility of the Padua project (North-Eastern Italy)
In conclusion, the key to success in managing pregnancy in obese women lies in sharing the various different health care competences required and taking the local resources into account. The prevention of obesity in women of fertile age remains the main problem, however, and further efforts are needed in this setting. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 7, 2017 Category: Endocrinology Source Type: research

Metabolic benefits of 1-(3-(4-( o -tolyl)piperazin-1-yl)propyl)pyrrolidin-2-one: a non-selective α-adrenoceptor antagonist
ConclusionNon-selective α-adrenoceptor antagonist seems to carry potential benefits in the improvement of the reduction of elevated glucose and triglyceride level. The lack of influence on blood pressure suggests that compounds with such a pharmacological profile may be particulary beneficial for the patients with disturb ed lipid and carbohydrate profile, who do not suffer from hypertension. These results are particulary valuable, since currently there are no safe α2A-adrenoceptor antagonist drugs available in clinical use with the ability to modulate hyperglycemia that would not affect blood pressure. (Source...
Source: Journal of Endocrinological Investigation - November 7, 2017 Category: Endocrinology Source Type: research

The effect of vitamin D supplementation in combination with low-calorie diet on anthropometric indices and androgen hormones in women with polycystic ovary syndrome: a double-blind, randomized, placebo-controlled trial
AbstractPurposePolycystic ovary syndrome (PCOS) is known as the most common endocrine disorder in reproductive age women. The aim of this studywas to evaluate the effects of vitamin D supplementation in combination with low-calorie diet on anthropometric indices, reproductive hormones and menstrual regularity in overweight and obese PCOS women.MethodsIn this randomized controlled clinical trial, 60 PCOS women with vitamin D insufficiency were randomly assigned to 12  weeks of either (1) weight-loss intervention + 50,000 IU/week oral vitamin D3 or (2) weight-loss intervention + placebo. At the ...
Source: Journal of Endocrinological Investigation - November 6, 2017 Category: Endocrinology Source Type: research

Androgenic alopecia in a postmenopausal Sicilian baroness
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 4, 2017 Category: Endocrinology Source Type: research

Recombinant growth hormone therapy for prepubertal children with idiopathic short stature in Korea: a phase III randomized trial
This study evaluated the efficacy and safety of Growtropin®-II (recombinant human GH) in Korean patients with ISS.MethodsThis was a 1-year, open-label, multicenter, phase III randomized trial of Growtropin®-II in Korean patients with ISS. In total, 70 prepubertal subjects (39 males, 31 females) between 4 and 12  years of age were included in the study. All patients were naive to GH treatment.ResultsAnnual height velocity was significantly higher in the treatment group (10.68  ± 1.95 cm/year) than the control group (5.72 ± 1.72,p 
Source: Journal of Endocrinological Investigation - November 4, 2017 Category: Endocrinology Source Type: research

25OH vitamin D levels in pediatric patients affected by Prader –Willi syndrome
AbstractPurposeObesity, insulin resistance, and puberty seem to influence and been inversely associated with 25-hydroxy vitamin D (25OHD) levels. To our knowledge, a study on 25OHD in children and adolescents with Prader –Willi syndrome (PWS), a genetic form of obesity, is not yet available.ObjectiveTo analyze the 25OHD values in pediatric PWS subjects in comparison with a control group (CNT), highlighting the possible correlations with IR, BMD, body composition, pubertal stage, and GH therapy (GHT).MethodsAuxological and laboratory parameters, HOMA-IR, Vitamin D status, and bone density and body composition by DEXA ...
Source: Journal of Endocrinological Investigation - November 3, 2017 Category: Endocrinology Source Type: research

Deregulation of the growth hormone/insulin-like growth factor-1 axis in adults with cystic fibrosis
ConclusionsAdult patients with CF may show GHD. These patients should be followed over time to assess if the GHD could impact the clinical progression of CF. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 2, 2017 Category: Endocrinology Source Type: research

Unnoticed maternal Graves ’ disease revealed by the baby’s low free thyroxine in newborn screening: an underestimated condition supporting thyroid disease screening among pregnant women
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - November 1, 2017 Category: Endocrinology Source Type: research

Modulatory effects of alpha-lipoic acid (ALA) administration on insulin sensitivity in obese PCOS patients
ConclusionsALA integrative administration at a low dosage as 400  mg daily improved the metabolic impairment of all PCOS patients especially in those PCOS with familiar diabetes who have a higher grade of risk of NAFLD and predisposition to diabetes. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 31, 2017 Category: Endocrinology Source Type: research

How to improve effectiveness of pegvisomant treatment in acromegalic patients
ConclusionsPEGV effectiveness improves when up titration is appropriate. Higher PEGV doses at start and a more rapid up-titration are necessary in patients with obesity and/or IGF-1  >  2.7 × ULN. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 28, 2017 Category: Endocrinology Source Type: research

Abnormal 1-hour post-load glycemia during pregnancy impairs post-partum metabolic status: a single-center experience
AbstractPurposeRecent evidence indicates that people with normal glucose tolerance (NGT) but 1-h post-load plasma glucose (1-h OGTT) ≥ 155 mg/dl have an increased risk for developing Type 2 diabetes mellitus (T2DM), determining a new risk category with deeper metabolic impairment. The aim of this study was to identify, among women with gestational diabetes (GDM), which alterations at OGTT during pregnancy are more frequently associated with 1-h OGTT ≥ 155 mg/dl at post-partum examination.MethodsAmong 297 women affected by GDM, we retrospectively evaluated 244 resulted NGT after delivery. Based on ...
Source: Journal of Endocrinological Investigation - October 24, 2017 Category: Endocrinology Source Type: research

The rs2910164 variant is associated with reduced miR-146a expression but not cytokine levels in patients with type 2 diabetes
AbstractPurposePrevious reports have demonstrated that genetic variations in microRNAs regulome could affect microRNAs-mediated regulation. Therefore, in the present study we were aimed at (1) comparison of microRNA 146-a (miR-146a) peripheral blood mononuclear cells (PBMCs) and plasma levels between diabetic patients and controls, and (2) investigating the possible association of rs2910164 with miR-146a and its related target genes expression and also serum cytokine levels.MethodsThe study population consisted of 60 subjects including 30 type 2 diabetes (T2D) patients and 30 controls with determined genotypes for rs291016...
Source: Journal of Endocrinological Investigation - October 22, 2017 Category: Endocrinology Source Type: research

Glucagon-like peptide-1 receptor agonists and atrial fibrillation: a systematic review and meta-analysis of randomised controlled trials
ConclusionsIn conclusion, available data suggest that GLP-1 RA is not associated with atrial fibrillation, with the only possible exception of albiglutide. Newly onset atrial fibrillation deserves to be investigated as an event of special interest in future trials with GLP-1 RA. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 20, 2017 Category: Endocrinology Source Type: research

Characterization and implications of thyroid dysfunction induced by immune checkpoint inhibitors in real-life clinical practice: a long-term prospective study from a referral institution
ConclusionsImmune checkpoint blockade is burdened by a high incidence of autoimmune thyroid dysfunction, which is often severe. Therefore, early and careful monitoring and, eventually, treatment are crucial to prevent the negative impact of thyroid dysfunction on the clinical outcome. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 17, 2017 Category: Endocrinology Source Type: research

The effects of add-on exenatide to insulin on glycemic variability and hypoglycemia in patients with type 1 diabetes mellitus
ConclusionAlthough exenatide could inhibit glucagon secretion during euglycemia or hyperglycemia in patients with T1DM, it has no effect on GLC and counter-regulatory hormones during hypoglycemia clamp in patients with no functional residual islet test. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 14, 2017 Category: Endocrinology Source Type: research