Tall cell and diffuse sclerosing variants of papillary thyroid cancer: outcome and predicting value of risk stratification methods
AbstractPurposeTall cell (TCV) and diffuse sclerosing (DSV) variants are aggressive variants of papillary thyroid cancer (PTC). We compared the risk of recurrent/persistent disease in patients with TCV, DSV and classical PTC (cPTC) and evaluated the prognostic accuracy of initial vs. ongoing risk stratification.MethodsA consecutive series of DSV (n = 54), TCV (n = 72) and cPTC (n = 184) patients was retrospectively analyzed. TCV and DSV patients were first risk stratified for recurrent/persistent disease without considering the histotype as a risk factor and subsequently, 6–24 month...
Source: Journal of Endocrinological Investigation - May 20, 2017 Category: Endocrinology Source Type: research

Plasma vascular endothelial growth factor B levels are increased in patients with newly diagnosed type 2 diabetes mellitus and associated with the first phase of glucose-stimulated insulin secretion function of β-cell
AbstractPurposeTo detect plasma vascular endothelial growth factor B (VEGF-B) in individuals with different glucose tolerance and investigate the relationship between plasma VEGF-B levels and the first phase of glucose-stimulated insulin secretion.MethodsA cross-sectional study was conducted involving 45 patients with newly diagnosed type 2 diabetes mellitus (T2DM), 37 patients with impaired glucose regulation (IGR), and 39 Normal glucose tolerance (NGT) subjects, all of whom underwent intravenous glucose tolerance test. Plasma VEGF-B levels were assayed by ELISA. The first phase of insulin secretion was evaluated by ac...
Source: Journal of Endocrinological Investigation - May 18, 2017 Category: Endocrinology Source Type: research

Does thyroid dysfunction increase the risk of breast cancer? A systematic review and meta-analysis
ConclusionsOur meta-analysis illustrated that thyroid dysfunction may not be related to increased risk of breast cancer as well as the thyroid hormone substitution treatment did not reduce the incidence of breast cancer; while this study has some confounders that might weaken the results of this meta-analysis, we believe that the findings provide valuable information for stakeholders concerned with outcomes in patients with thyroid dysfunction. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 17, 2017 Category: Endocrinology Source Type: research

Anti-thyroglobulin antibodies do not significantly increase the risk of finding iodine avid metastases on post-radioactive iodine ablation scan in low-risk thyroid cancer patients
AbstractObjective Post-operative thyroglobulin (Tg) levels can predict the likelihood of residual cancer, including distant metastases, thereby influencing postsurgical treatment strategies even in patients with low-risk disease. Circulating anti-thyroglobulin antibodies (anti-Tg Abs) interfere with Tg measurement preventing this clinical use. It is not known if the presence of anti-Tg Abs predicts metastatic disease on post-therapy scan in patients with low-risk disease or if they should influence the use or dose of I-131 therapy. In the present study, we compare post-therapy scans in low-risk patients with and without ...
Source: Journal of Endocrinological Investigation - May 16, 2017 Category: Endocrinology Source Type: research

Testosterone insulin-like effects: an in vitro study on the short-term metabolic effects of testosterone in human skeletal muscle cells
ConclusionAll together our data indicate that testosterone through the activation of non-genomic pathways, participates in skeletal muscle glucose metabolism by inducing insulin-related effects. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 15, 2017 Category: Endocrinology Source Type: research

In memory of Professor Aldo Isidori
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 10, 2017 Category: Endocrinology Source Type: research

Chronic prostatitis and its detrimental impact on sperm parameters: a systematic review and meta-analysis
AbstractPurposeProstatitis is a very common urogenital disease of the male with prevalence ranging from 2.2 to 9.7% worldwide. Interestingly, some recent evidences have showed a significant association between chronic prostatitis (CP) and male infertility including a detrimental effect on sperm parameters, reduction of zinc concentration on semen sperm and production of anti-semen antibodies (ASAs). The aim of the current meta-analysis was to evaluate the association between CP and alteration of semen parameters.MethodsThis analysis was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-an...
Source: Journal of Endocrinological Investigation - May 9, 2017 Category: Endocrinology Source Type: research

Associations of blood glucose dynamics with antihyperglycemic treatment and glycemic variability in type 1 and type 2 diabetes
AbstractAimsThe dynamical structure of glucose fluctuation has largely been disregarded in the contemporary management of diabetes.MethodsIn a retrospective study of patients with diabetes, we evaluated the relationship between glucose dynamics, antihyperglycemic therapy, glucose variability, and glucose exposure, while taking into account potential determinants of the complexity index. We used multiscale entropy (MSE) analysis of continuous glucose monitoring data from 131 subjects with type 1 (n = 18), type 2 diabetes (n = 102), and 11 nondiabetic control subjects. We compared the MSE complexity index...
Source: Journal of Endocrinological Investigation - May 8, 2017 Category: Endocrinology Source Type: research

IUGR induced by maternal chronic inflammation: long-term effect on offspring ’s ovaries in rat model—a preliminary report
ConclusionsChronic maternal inflammation induced intrauterine growth restriction in offspring and a decrease in the proportion of follicles. This change might be due to premature apoptosis. These preliminary results suggest that maternal inflammation has a detrimental effect on the development of the female reproductive system of the offspring and thus, future fertility. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 6, 2017 Category: Endocrinology Source Type: research

Apparent biochemical thyrotoxicosis due to assay interference by high-dose biotin given for multiple sclerosis
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 6, 2017 Category: Endocrinology Source Type: research

Risk score model of type 2 diabetes prediction for rural Chinese adults: the Rural Deqing Cohort Study
ConclusionsOur non-invasive RS model can be used to identify individuals who are at high risk of T2DM as a simple, fast, and cost-effective tool for rural Chinese adults. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 4, 2017 Category: Endocrinology Source Type: research

Ultrasound characterization of insulin induced lipohypertrophy in type 1 diabetes mellitus
ConclusionsUltrasound scan can help identify and characterize the lipohypertrophic areas and this might be useful to improve glycemic control. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 27, 2017 Category: Endocrinology Source Type: research

Head of an old goitrous woman
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 25, 2017 Category: Endocrinology Source Type: research

Physical performance in newly diagnosed hypothyroidism: a pilot study
AbstractObjectiveHypothyroidism is complicated by neuromuscular symptoms (myalgias, slowness of movements, and tiredness) and signs (easy fatigability and cramps), which may have a negative impact on general well-being and quality of life. In a pilot, prospective, controlled study, we investigated the features of muscle dysfunction in hypothyroidism by disease questionnaire, biochemical measures, and physical performance tests.Materials and MethodsFifty-seven consecutive patients with newly diagnosed hypothyroidism were enrolled, 27 subclinical (S-Hypo) and 30 overt (O-Hypo). A series of 30 euthyroid subjects, with similar...
Source: Journal of Endocrinological Investigation - April 22, 2017 Category: Endocrinology Source Type: research

Transoral thyroidectomy: advantages and limitations
AbstractIn this opinion paper of theJournal of Endocrinological Investigation, leading experts in the field report on their current clinical experience with a novel approach for thyroid gland surgery, namely, “transoral thyroidectomy” (TOT). This feasible and novel surgical procedure does not require visible incisions and is, therefore, a truly scarless surgery. Patients meeting the following criteria can be considered as candidates for TOT: (a) an ultrasonographically (US) estimated thyroid diameter ≤10 cm; (b) US-estimated gland volume ≤45 mL; (c) nodule size ≤50 mm; (d) presence of a ...
Source: Journal of Endocrinological Investigation - April 21, 2017 Category: Endocrinology Source Type: research

Erratum to: Long-term safety and efficacy of Omnitrope ® in adults with growth hormone deficiency: Italian interim analysis of the PATRO Adults study
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 18, 2017 Category: Endocrinology Source Type: research

Influence of exercise intervention on gestational diabetes mellitus: a systematic review and meta-analysis
ConclusionsCompared to control intervention, exercise intervention was found to significantly reduce the incidence of gestational diabetes mellitus, but had no significant influence on preterm birth, gestational age at birth, glucose 2-h post-OGTT, birth weight, Apgar score less than 7, and preeclampsia. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 12, 2017 Category: Endocrinology Source Type: research

Association between low C-peptide and fragility fractures in postmenopausal women without diabetes
AbstractPurposeC-peptide has been shown to exert several, previously unknown, biological effects. A recent cross-sectional study demonstrated an association between low C-peptide serum levels and low lumbar bone density of postmenopausal women not affected by diabetes. To date, very little research attention has been directed toward the association between C-peptide and osteoporotic fractures. To contribute toward filling this gap, we investigated the association between C-peptide and fractures in postmenopausal women.MethodsA cohort of 133 non-diabetic postmenopausal women with and without a history of fractures was evalu...
Source: Journal of Endocrinological Investigation - April 11, 2017 Category: Endocrinology Source Type: research

Fluid intelligence, traits of personality and personality disorders in a cohort of adult KS patients with the classic 47, XXY karyotype
ConclusionsMost KS patients had average fluid intelligence. PD prevalence was higher than in the general population. Testosterone was not correlated with fluid intelligence, personality traits or PD, but a reduction in marital distress was observed in treated patients. This could suggest that testosterone therapy can improve physical symptoms and this effect could also improve relationship abilities and wellness awareness. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 11, 2017 Category: Endocrinology Source Type: research

The fight between a dwarf and a stork (Mosaic I century BC)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 11, 2017 Category: Endocrinology Source Type: research

Validation of the Italian Quality of Life in Short Stature Youth (QoLISSY) questionnaire
ConclusionIn conclusion, the Italian QoLISSY HrQoL-dimensions are comparable to other European countries. The psychometric quality of the Italian QoLISSY version is satisfactory and the instrument is ready for use in Italian patients and their parents. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 10, 2017 Category: Endocrinology Source Type: research

Prepubertal ultra-low-dose estrogen therapy is associated with healthier lipid profile than conventional estrogen replacement for pubertal induction in adolescent girls with Turner syndrome: preliminary results
ConclusionPrepubertal LE is associated with healthier lipid profile than CE in girls with TS. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 10, 2017 Category: Endocrinology Source Type: research

Quality of life after thyroid surgery
ConclusionsQuality of life increased after total thyroidectomy and statistically significant improvement was observed in late post-operative stage. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 10, 2017 Category: Endocrinology Source Type: research

Profiling of selenium absorption and accumulation in healthy subjects after prolonged l -selenomethionine supplementation
ConclusionsProlonged selenomethionine administration increases circulating blood selenium concentration and hydride generation atomic fluorescence spectroscopy enables its accurate quantification. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 9, 2017 Category: Endocrinology Source Type: research

Influence of vitamin D levels on the cardiovascular profile of hypogonadal men
AbstractPurpose A large body of evidence suggests a role for vitamin D in conditioning cardiovascular risk. Therefore, it can be hypothesized that vitamin D might also play a role in influencing the metabolic profile of hypogonadal men. In this work, we aimed at evaluating if any relationship exists between vitamin D levels and cardiovascular parameters in male hypogonadism.Methods Hypogonadal patients attending our andrology unit were retrospectively reviewed. Clinical and biochemical parameters were evaluated.Results103 patients were studied (51 non-diabetic and 52 diabetic subjects). Mean age of the whole sample was...
Source: Journal of Endocrinological Investigation - April 8, 2017 Category: Endocrinology Source Type: research

The effect of PPAR γ agonist on SGLT2 and glucagon expressions in alpha cells under hyperglycemia
ConclusionIn conclusion, PPAR γ agonist, troglitazone improved glucose transport SGLT2 dysfunction and subsequent glucagon dysregulation in alpha cell under hyperglycemia. Those effects were through the involvement of PI3K/pAkt signaling pathway. This study may add one more reason for the ideal combination of PPARγ agonist and SGLT2 inhibitor in clinical practice. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 8, 2017 Category: Endocrinology Source Type: research

“Metabolic and cardiovascular response to exercise in patients with type 1 diabetes”
ConclusionsPatients affected by T1DM have a worse exercise tolerance than normal subjects. The two groups differed by RER which can be greatly influenced by the substrate type utilized to produce energy. Because of the impaired carbohydrate utilization, T1DM subjects may use a larger amount of lipid substrates, such hypothesis could be strengthened by the lower lactate levels found in T1DM group at peak exercise. The lack of correlation between exercise tolerance and disease-related variables suggests that the alterations found could be independent from the glycemic levels. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 6, 2017 Category: Endocrinology Source Type: research

Binding of thyroglobulin (Tg) to the low-density lipoprotein receptor-associated protein (RAP) during the biosynthetic pathway prevents premature Tg interactions with sortilin
ConclusionsTg does not bind prematurely to sortilin because of its interaction with RAP during protein biosynthesis. These findings add new information to the knowledge of thyroid physiology. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 5, 2017 Category: Endocrinology Source Type: research

Association of established hypothyroidism-associated genetic variants with Hashimoto ’s thyroiditis
ConclusionsSH2B3 gene has previously been associated with susceptibility to several autoimmune diseases, whereasPDE8B has been associated with TSH levels and suggested to modulate thyroid physiology that may influence the manifestation of thyroid disease. Identified loci are novel and biologically plausible candidates for HT development and represent good basis for further exploration of HT susceptibility. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 5, 2017 Category: Endocrinology Source Type: research

A randomized, open-label, controlled trial to evaluate the antimicrobial and surgical effect of CO 2 laser treatment in diabetic infected foot ulcers: DULCIS (diabetic ulcer, CO 2 laser, and infections) study
ConclusionsDebridement of ulcers with CO2 laser significantly reduces bacterial load and fibrin-covered areas, and could be of help in the treatment of diabetic foot ulcer. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 4, 2017 Category: Endocrinology Source Type: research

Less is more: time to expand the indications for minimally invasive video-assisted parathyroidectomy
ConclusionMIVAP offers the ability to perform a neck exploration and/or an en bloc thyroid lobectomy without the need to convert to a standard cervicotomy. Therefore, it not only serves as a targeted parathyroid procedure but also a potential alternative to full neck exploration. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 3, 2017 Category: Endocrinology Source Type: research

Long-term blood glucose monitoring with implanted telemetry device in conscious and stress-free cynomolgus monkeys
ConclusionOur data demonstrate that the real-time telemetry method is reliable for monitoring blood glucose remotely and continuously in conscious, stress-free, and moving-free NHPs with the advantages highly valuable to diabetes research and drug discovery. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 1, 2017 Category: Endocrinology Source Type: research

In remembrance of Professor Mario Andreoli (1929 –2016)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 30, 2017 Category: Endocrinology Source Type: research

Diabetic retinopathy: new therapeutic perspectives based on pathogenic mechanisms
AbstractDiabetic retinopathy (DR) is the leading cause of visual impairment and preventable blindness and represents a significant socioeconomic cost for healthcare systems worldwide. In early stages of DR the only therapeutic strategy that physicians can offer is a tight control of the risk factors for DR (mainly blood glucose and blood pressure). The currently available treatments for DR are applicable only at advanced stages of the disease and are associated with significant adverse effects. Therefore, new treatments for the early stages of DR are needed. However, in early stages of DR invasive treatments such as intrav...
Source: Journal of Endocrinological Investigation - March 29, 2017 Category: Endocrinology Source Type: research

Psychological characteristics of Italian gender dysphoric adolescents: a case –control study
AbstractPurposeGender dysphoria (GD) is associated with clinically significant distress and impairment in social, scholastic, and other important areas of functioning, especially when early onset is reported. The aim of the present study is to assess the psychopathological features associated with GD in adolescence, comparing a group of gender dysphoric adolescents (GDs) with a group of non-referred adolescents (NRs), in terms of body uneasiness, suicide risk, psychological functioning, and intensity of GD.MethodsA sample of 46 adolescents with GD and 46 age-matched NRs was evaluated (mean  ± SD age&th...
Source: Journal of Endocrinological Investigation - March 29, 2017 Category: Endocrinology Source Type: research

Utility of baseline serum phosphorus levels for predicting remission in acromegaly patients
AbstractPurposeHigh GH and IGF I levels increase tubular phosphate reabsorption in patients with acromegaly. We aimed to investigate the utility of serum phosphorus levels as an indicator for predicting chance of remission in acromegaly patients.DesignFifty-one patients (n: 51;F: 24,M: 27) with diagnosis of acromegaly were included in the study. Plasma IGF-1, Phosphorus (P) and nadir GH levels on oral glucose tolerance test (OGTT) at the time of diagnosis were analysed retrospectively. Patients were classified into two groups according to their plasma P levels;P ≤ 4.5 mg/dl (Group-1,n: 23, 45.1%),P&nb...
Source: Journal of Endocrinological Investigation - March 29, 2017 Category: Endocrinology Source Type: research

Do glucocorticoids induce addiction in humans?
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 25, 2017 Category: Endocrinology Source Type: research

Prevalence of thyroid dysfunction and its impact on cognition in older mexican adults: (SADEM study)
AbstractIntroductionSubclinical thyroid dysfunction is a possible risk factor for cognitive impairment in old age, but results are inconsistent. Aim of the present study was to evaluate the prevalence of thyroid dysfunction among older community-dwelling adults and to see whether thyroid function impacts the cognitive status of the elderly.MethodsWe included 1750 participants from the Study on Aging and Dementia in Mexico (SADEM). All subjects were evaluated clinically via specific interviews. TSH levels were analyzed by chemiluminescent immunometry assay. We classified participants into five thyroid state groups: (1) norm...
Source: Journal of Endocrinological Investigation - March 25, 2017 Category: Endocrinology Source Type: research

Painful Hashimoto ’s thyroiditis: myth or reality?
AbstractNeck pain is a common complain, being in most cases due to non-thyroidal causes. However, a minority of patients suffer from painful thyroid diseases. Among them, sub-acute thyroiditis (SAT) is the most frequent one. Rare thyroid-related causes of neck pain include hemorrhage within a thyroid nodule as well as Riedel ’s thyroiditis and suppurative thyroiditis. In the last 30 years, a few cases of a painful variant of Hashimoto’s thyroiditis (HT) have been described. Biochemical, ultrasound, and histologic features were clearly suggestive for HT in all of the published cases and definitely ruled out...
Source: Journal of Endocrinological Investigation - March 24, 2017 Category: Endocrinology Source Type: research

Gly972Arg of IRS-1 and Lys121Gln of PC-1 polymorphisms act in opposite way in polycystic ovary syndrome
ConclusionsGenetic variations in insulin signaling contribute to the extent and the variability of metabolic and hormonal derangement. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 23, 2017 Category: Endocrinology Source Type: research

Primary cilium is required for the stimulating effect of icaritin on osteogenic differentiation and mineralization of osteoblasts in vitro
ConclusionPrimary cilia are important in mediating icaritin-stimulated osteogenic differentiation and may be a novel target for pharmacological therapies for bone loss. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 23, 2017 Category: Endocrinology Source Type: research

Habitual physical activity is associated with improved anthropometric and androgenic profile in PCOS: a cross-sectional study
AbstractPurposeTo examine the effect of habitual physical activity (PA) on the metabolic and hormonal profiles of women with polycystic ovary syndrome.Materials and methodsAnthropometric, metabolic and hormonal assessment and determination of habitual PA levels with a digital pedometer were evaluated in 84 women with PCOS and 67 age- and body mass index (BMI)-matched controls. PA status was defined according to number of steps ( ≥7500 steps, active, or
Source: Journal of Endocrinological Investigation - March 23, 2017 Category: Endocrinology Source Type: research

Sport and male sexuality
AbstractThe relationships between sport and sexuality in males are of great social and clinical interest, because of sports and motor activities that highly promote social and sexual relationships. Even if few literature exist, two main questions should be taken into account: whether and how physical exercise and sport positively or negatively influence sexual health and behavior and/or whether and how sexual behavior may affect a sub-sequent sport performance. Physical exercise and sport per se can influence, positively or negatively, the hypothalamic-pituitary-testicular axis function and, consequently, the individual &r...
Source: Journal of Endocrinological Investigation - March 22, 2017 Category: Endocrinology Source Type: research

Quantitative ultrasound and DXA measurements in aromatase inhibitor-treated breast cancer women receiving denosumab
AbstractPurposeDenosumab has been proven to reduce fracture risk in breast cancer (BC) women under aromatase inhibitors (AIs). Quantitative ultrasound (QUS) provides information on the structure and elastic properties of bone. Our aim was to assess bone health by phalangeal QUS and by dual-energy X-ray absorptiometry (DXA), and to evaluate bone turnover in AIs-treated BC women receiving denosumab.Methods35 Postmenopausal BC women on AIs were recruited (mean age 61.2  ± 4.5 years) and treated with denosumab 60 mg administered subcutaneously every 6 months. Phalangeal QUS parameters [Amplitude ...
Source: Journal of Endocrinological Investigation - March 22, 2017 Category: Endocrinology Source Type: research

The association between polycystic ovary syndrome, obesity, and the serum concentration of adipokines
ConclusionsWhile no sufficient evidence is available with regard to the causal association between adipokines and PCOS, they may contribute to the development of PCOS and regarded as the novel biomarkers of PCOS. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 22, 2017 Category: Endocrinology Source Type: research

The steroid response to human chorionic gonadotropin (hCG) stimulation in men with Klinefelter syndrome does not change using immunoassay or mass spectrometry
ConclusionsAlthough a linearity between IA and LC-MS/MS is demonstrated, LC-MS/MS is more sensitive and accurate, whereas IA shows a constant overestimation of sex steroid levels. This result suggests the need of reference intervals built on the specific assay. This fundamental difference between these two methodologies opens a deep reconsideration of what is needed to improve the accuracy of steroid hormone assays. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 21, 2017 Category: Endocrinology Source Type: research

Analysis of the main risk factors for gestational diabetes diagnosed with International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria in multiple pregnancies
AbstractIntroductionThe aim is to investigate the proportion of multiple pregnancies with gestational diabetes mellitus (GDM) diagnosed using the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria and to identify the impact of age, body mass index (BMI), and mode of conception on incidence of GDM.Materials and methodsThis is a single center, retrospective cohort study on 656 multiple pregnancies screened for GDM with 75-g, 2-h oral glucose tolerance test at 24 –28 weeks of gestation, between January 2010 and January 2016. The diagnosis of gestational diabetes mellitus (GDM) was re...
Source: Journal of Endocrinological Investigation - March 20, 2017 Category: Endocrinology Source Type: research

The effect of rLH supplementation to the GnRH-antagonist protocol on endocrine dynamics in the advanced reproductive age
ConclusionsDifferent strategies to explore LH dynamics following the GnRH-antagonist administration have resulted in diverse results, implying the need for a consensus definition of LH threshold for adequate folliculogenesis and steroidogenesis. Such action would pave the way for understanding which groups of patients may benefit from rLH supplementation. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 12, 2017 Category: Endocrinology Source Type: research

Gestational diabetes mellitus: an updated overview
AbstractThe clinical and public health relevance of gestational diabetes mellitus (GDM) is widely debated due to its increasing incidence, the resulting negative economic impact, and the potential for severe GDM-related pregnancy complications. Also, effective prevention strategies in this area are still lacking, and controversies exist regarding diagnosis and management of this form of diabetes. Different diagnostic criteria are currently adopted worldwide, while recommendations for diet, physical activity, healthy weight, and use of oral hypoglycemic drugs are not always uniform. In the present review, we provide an upda...
Source: Journal of Endocrinological Investigation - March 9, 2017 Category: Endocrinology Source Type: research

Investigation on the association between thyroid tumorigeneses and herpesviruses
AbstractHerpesviruses have been associated with various human malignancies and with thyroid autoimmunity. Aiming to investigate the presence of these viruses in thyroid nodules, we analyzed serum and thyroid tissue from 183 patients (83 benign and 100 malignant thyroid nodules). We also obtained 104 normal thyroid tissues extracted from the contralateral lobe of these patients. We used ELISA to screen the serology of all patients and a real-time quantitative PCR to analyze thyroid tissue viral load in antibody-positive patients. In addition, the presence of herpesviruses was tested by histological analysis in 20 EBV-positi...
Source: Journal of Endocrinological Investigation - March 7, 2017 Category: Endocrinology Source Type: research