Evaluation of the Italian cytological subclassification of thyroid indeterminate nodules into TIR-3A and TIR-3B: a retrospective study of 290 cases with histological correlation from a single institution
ConclusionsThe study supports the Italian consensus showing a different risk of malignancy for TIR-3A as compared to TIR-3B. TIR-3A/TIR-3B subclassification is valid to sort out benign nodules (high NPV) and malignancies (high sensitivity) but not adenomas (modest specificity, low PPV). In our experience, sensitivity is the main difference between Italian and Bethesda systems. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 25, 2017 Category: Endocrinology Source Type: research

Interaction between gender and uric acid on hemoglobin A1c in community-dwelling persons
AbstractIntroductionHigher glycated hemoglobin (Hb) (HbA1c) is significantly associated with an increased risk of cardiovascular disease (CVD). Serum uric acid (SUA) levels are associated with glucose intolerance and type 2 diabetes. Whether gender-specific differences regarding the relationship between SUA levels and HbA1c exist is unknown.AimWe recruited 1636 (men, 696 aged of 70  ± 10 years; women, 940 aged of 70 ± 9 years) participants and enrolled in the study during their annual health examination from a single community. We investigated the association between SUA levels a...
Source: Journal of Endocrinological Investigation - September 25, 2017 Category: Endocrinology Source Type: research

Androgen excess and metabolic disorders in women with PCOS: beyond the body mass index
ConclusionsMetabolic impairment seems not to be dependent only on the total fat mass content and body weight in women with PCOS and might be ascribed to the androgen excess. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 23, 2017 Category: Endocrinology Source Type: research

Anti-parietal cell antibodies in patients with autoimmune thyroid diseases
ConclusionsThere is a high prevalence of positive APCA in ATD patients. APCA are more common in those with anemia and less common in those with complaints of heartburn. Almost half of positive APCA patients had atrophic gastritis. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 19, 2017 Category: Endocrinology Source Type: research

Effects of tetramethylpyrazine phosphate on pancreatic islet microcirculation in SD rats
In this study, we investigated whether tetramethylpyrazine phosphate (TMPP), a vasoactive substance, could regulate the islet microcirculation and insulin concentration and improve glycaemia in SD rats.MethodsSD rats were randomly divided into two groups, the control and TMPP groups. Each group was further divided into three subgroups according to the intravenous injection of either saline, 15 or 30% glucose. The non-radioactive microsphere technique was adopted to measure the organ blood flow. Nitric oxide synthase (NOS) blockerl-NAME was used to address whether NO was involved in mediating the vasoactive effects of TMPP....
Source: Journal of Endocrinological Investigation - September 16, 2017 Category: Endocrinology Source Type: research

Hypothyroidism in the “Arnolfini Portrait” (1434) by Jan Van Eyck (1390–1441)
ConclusionsThis novel diagnosis offers an additional perspective to this enigmatic portrait, and can add to the comprehension of the method, origin and pathological associations of this prominent painting from a genius artist. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 9, 2017 Category: Endocrinology Source Type: research

Clinical and pathologic predictors of central lymph node metastasis in papillary thyroid microcarcinoma: a retrospective cohort study
AbstractObjectiveTo identify the clinical and pathological predictors of central lymph node metastasis (CLNM) in patients with clinically lymph node-negative papillary thyroid microcarcinoma (PTMC).Materials and methodsData pertaining to 541 clinically lymph node-negative PTMC patients who underwent thyroid surgery at the Shanghai General Hospital between January 2010 and December 2013 were retrospectively analyzed. According to histopathological evidence of central lymph node involvement, patients were divided into central lymph node metastasis (CLNM)-positive and CLNM-negative groups; risk factors for CLNM were identifie...
Source: Journal of Endocrinological Investigation - September 7, 2017 Category: Endocrinology Source Type: research

High prevalence of papillary thyroid carcinoma in nodular Hashimoto ’s thyroiditis at the first diagnosis and during the follow-up
AbstractBackgroundThe association between Hashimoto ’s thyroiditis (HT) and papillary thyroid carcinoma (PTC) remains to be elucidated.Materials and methodsA total of 484 HT patients were retrospectively subdivided into two groups: 243 without thyroid nodules, TNs (HTN −) and 241 with TNs (HTN+). Fine-needle aspiration cytology was available in 152 HTN+ patients. This group was compared to a group of 161 patients with nodular goiter (NG) without HT. Finally, 70 HTN+ and 37 NG patients underwent surgery.ResultsA very high prevalence of suspicious/malignant cytology (Thy 4 –5) at the first diagnosis (38/124...
Source: Journal of Endocrinological Investigation - September 5, 2017 Category: Endocrinology Source Type: research

Ultrasound variants of autoimmune thyroiditis in children and adolescents and their clinical implication in relation to papillary thyroid carcinoma development
ConclusionPatients with AIT and nodular variant with normoechogenic irregular background of the thyroid gland on US scans are in the risk group of developing PTC and should be followed up with regular neck US assessment. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 2, 2017 Category: Endocrinology Source Type: research

Role of sentinel node in differentiated thyroid cancer: a prospective study comparing patent blue injection technique, lymphoscintigraphy and the combined technique
ConclusionAdditional well-designed randomized studies are needed to validate and further optimize the SLN biopsy in patients with differentiated thyroid cancer. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 31, 2017 Category: Endocrinology Source Type: research

TSH oscillations in young patients with type 1 diabetes may be due to glycemic variability
ConclusionsOur results suggest a direct action of glycemic excursions on TSH secretion, regardless of variations of thyroid hormone concentrations. Thus, the evaluation of thyroid function through the assay of TSH concentrations in these patients should be made, if possible, by multiple samples on patients in euglycemic state to avoid underestimation or overestimation of thyroid dysfunction due to a wrong diagnosis of euthyroidism or dysthyroidism with consequent inappropriate choice of therapeutic options. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 30, 2017 Category: Endocrinology Source Type: research

Use of low-dose radioiodine ablation for Graves ’ orbitopathy: results of a pilot, perspective study in a small series of patients
ConclusionsOur findings may provide a preliminary basis for the use of a 15  mCi dose of radioiodine upon rhTSH stimulation in thyroidectomized patients with Graves’ hyperthyroidism and GO. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 30, 2017 Category: Endocrinology Source Type: research

Deiodinases and stem cells: an intimate relationship
AbstractThyroid hormone is a major determinant of tissue functions in vivo. The deiodinase family controls the tissue-specific activation or inactivation of intracellular thyroid hormones. Precise control of the T3-dependent transcriptional program is required by multiple cell systems, including the stem cell. In this context, the identification of a close connection between thyroid hormones and different signal pathways involved in the control of stem cell functions suggested that the deiodinases may play a role in the definition of stem cell biology and physiology. Stem cells have an unlimited self-renewal capacity and t...
Source: Journal of Endocrinological Investigation - August 29, 2017 Category: Endocrinology Source Type: research

Thyroid diseases and bone health
AbstractThyroid hormones are essential for skeletal development and are important regulators of bone maintenance in adults. Childhood hypothyroidism causes delayed skeletal development, retarded linear growth and impaired bone mineral accrual. Epiphyseal dysgenesis is evidenced by classic features of stippled epiphyses on X-ray. In severe cases, post-natal growth arrest results in a complex skeletal dysplasia. Thyroid hormone replacement stimulates catch-up growth and bone maturation, but recovery may be incomplete dependent on the duration and severity of hypothyroidism prior to treatment. A severe phenotype characteristi...
Source: Journal of Endocrinological Investigation - August 29, 2017 Category: Endocrinology Source Type: research

G αq/p63RhoGEF interaction in RhoA/Rho kinase signaling: investigation in Gitelman’s syndrome and implications with hypertension
ConclusionsGitelman ’s syndrome normo/hypotension and lack of cardiovascular–renal remodeling are not due to mutations of p63RhoGEF α6–αN linker and Gαq interactions. This opens the way for investigations on different coding and no-coding regions (p63RhoGEF and Gαq promoters) and on altered transcriptional/po st-transcriptional regulation. Clarification of how these biochemical/molecular mechanisms work/interact would provide insights into mechanisms involved in the GS’s Ang II signaling fine tuning, in human physiology/pathophysiology in general and could also identify signi...
Source: Journal of Endocrinological Investigation - August 24, 2017 Category: Endocrinology Source Type: research

Interpretation of thyroid scintigraphy is inconsistent among endocrinologists
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 23, 2017 Category: Endocrinology Source Type: research

Reproducibility and validity of the Italian version of the International Physical Activity Questionnaire in obese and diabetic patients
AbstractPurposeAims of this study were to evaluate the agreement between the short and long versions of the International Physical Activity Questionnaire (IPAQ: Italian versions), their reproducibility (agreement and reliability) and construct validity (relative to pedometry) in a clinical population.MethodsNinety patients affected by obesity (N = 39), type 2 diabetes mellitus (N = 26) or both (N = 25) were recruited. They were asked to maintain their usual physical activity habits during two consecutive weeks and to fill the questionnaires twice (at the end of each week). They were also asked...
Source: Journal of Endocrinological Investigation - August 19, 2017 Category: Endocrinology Source Type: research

The baptism of the Princes of Marseille Gaudenzio Ferrari (1475 –1546)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 18, 2017 Category: Endocrinology Source Type: research

Correlation between adrenal function, growth hormone secretion, and insulin sensitivity in children with idiopathic growth hormone deficiency
AbstractPurposePatients with growth hormone deficiency (GHD) demonstrate an increased cortisol/cortisone ratio which could potentially explain the metabolic features of GHD, while GH treatment (GHT) could increase the cortisol metabolism.MethodsIn 35 children (27  M, mean age 10.1 years) with idiopathic GHD at baseline and after 12 months of GHT and in 25 controls, in addition to metabolic parameters, we assessed adrenal function by morning serum cortisol, its peak, and its area under the curve (AUCCOR) during insulin tolerance test (ITT).ResultsA cortisol peak
Source: Journal of Endocrinological Investigation - August 18, 2017 Category: Endocrinology Source Type: research

Polyglandular autoimmune syndromes
ConclusionsEarly detection of specific autoantibodies and latent organ-specific dysfunction is advocated to alert physicians to take appropriate action in order to prevent full-blown PAS disease. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 17, 2017 Category: Endocrinology Source Type: research

Growth hormone treatment improves final height and nutritional status of children with chronic kidney disease and growth deceleration
AbstractPurposeGrowth retardation is a common complication of chronic kidney disease (CKD) in children. Treatment with recombinant human growth hormone (rhGH) has been used to help short children with CKD to attain a height more in keeping with their age group, but the scientific evidence regarding the effect of rhGH on final height is scarce.MethodsFinal heights of children with CKD receiving rhGH treatment (cases) were compared with final heights of a matched cohort of children with CKD that did not receive rhGH therapy (controls).ResultsSixty-eight rhGH-treated cases (44 boys) were compared with 92 untreated controls (6...
Source: Journal of Endocrinological Investigation - August 17, 2017 Category: Endocrinology Source Type: research

Diagnostic performance of a newly developed salivary cortisol and cortisone measurement using an LC –MS/MS method with simple and rapid sample preparation
ConclusionsLate-night salivary cortisol and cortisone are useful parameters for the diagnosis of hypercortisolism. Using samples obtained from patients where the diagnosis of hypercortisolism is extremely challenging cut-off values for midnight salivary cortisol and cortisone measured by LC –MS/MS method were established. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 16, 2017 Category: Endocrinology Source Type: research

Does hypoglycaemia affect the improvement in QoL after the transition to insulin in people with type 2 diabetes?
AbstractPurposeQuality of Life (QoL) of insulin-na ïve people with type 2 diabetes mellitus (T2DM) improves after transition to insulin. Little is known about the role of hypoglycaemia in this context. Secondary analyses of the Study of the Psychological Impact in Real care of Initiating insulin glargine Treatment (SPIRIT) aimed to investigate the relationship between hypoglycaemia and QoL when transitioning to insulin.MethodsInsulin-na ïve Dutch people with T2DM in suboptimal glycaemic control (HbA1c>53  mmol/mol; 7.0%) on maximum dose of oral glucose-lowering medications were included from 363 primary c...
Source: Journal of Endocrinological Investigation - August 12, 2017 Category: Endocrinology Source Type: research

Sense of coherence, self-esteem, and health locus of control in subjects with type 1 diabetes mellitus with/without satisfactory metabolic control
AbstractBackgroundDespite intensive training, a few individuals with Type 1 diabetes mellitus (T1DM) fail to reach the desired metabolic targets.AimTo evaluate the association between disease-related emotional and cognitive aspects and metabolic control in subjects with T1DM.Subjects and methodsHealth locus of control (HLOC), sense of coherence (SOC), and self-esteem were assessed in T1DM subjects using validated questionnaires. Sixty-seven consecutive subjects who did not attain the desired HbA1c target (mean HbA1c, 8.3% [67  mmol/mol]) were compared with 30 cases in satisfactory metabolic control (HbA1c levels
Source: Journal of Endocrinological Investigation - August 12, 2017 Category: Endocrinology Source Type: research

Effect of Cholecalciferol therapy on serum FGF 23 in vitamin D deficient patients: a randomized clinical trial
AbstractIntroductionFibroblast growth factor-23 plays an important role in regulating systemic phosphate homeostasis, and vitamin D metabolism. However, the effect of Cholecalciferol therapy on FGF23 serum level in patients with vitamin D deficiency has not been studied, yet.Materials and methodsThis is a double-blind, randomized clinical trial on 119 vitamin D deficient patients in 2016. Biochemical variables of treatment and placebo groups were analyzed after 12  weeks of 50,000 IU of Cholecalciferol vs. placebo therapy once a week, by SPSS18.ResultsAfter Cholecalciferol therapy, delta of serum PTH in treatment...
Source: Journal of Endocrinological Investigation - August 9, 2017 Category: Endocrinology Source Type: research

The effect of primary hyperparathyroidism on pancreatic exocrine function
ConclusionsChronic hypercalcemia in primary hyperparathyroidism did not decrease the fecal elastase level, which is an indirect indicator of chronic pancreatitis; therefore, chronic hypercalcemia in PHPT may not cause chronic pancreatitis. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - August 2, 2017 Category: Endocrinology Source Type: research

The role of microRNAs in different types of thyroid carcinoma: a comprehensive analysis to find new miRNA supplementary therapies
AbstractThe most common endocrine malignancy is thyroid cancer, and researchers have made a great deal of progress in deciphering its molecular mechanisms in the recent years. Many of molecular changes observed in thyroid cancer can be used as biomarkers for diagnosis, prognosis, and therapeutic targets for treatment. MicroRNAs (miRNAs) are important parts in biological and metabolic pathways such as regulation of developmental stages, signal transduction, cell maintenance, and differentiation. Therefore, their dysregulation can expose individuals to malignancies. It has been proved that miRNA expression is dysregulated in...
Source: Journal of Endocrinological Investigation - July 31, 2017 Category: Endocrinology Source Type: research

Non-surgical ablative therapies for inoperable benign insulinoma
ConclusionsNon-surgical ablation is a feasible, safe and repeatable procedure in patients with pancreatic insulinoma, who are not candidate to surgery or refuse it. Partial or complete control of symptoms and tumor growth is experienced by the majority of patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 28, 2017 Category: Endocrinology Source Type: research

Gender differences in the association of ELMO1 genetic variants with type 2 diabetes in Tunisian Arabs
ConclusionThese results confirm role forELMO1 as T2DM susceptibility locus, which appears to be gender-dependent. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 27, 2017 Category: Endocrinology Source Type: research

Jusepe de Ribera “Lo Spagnoletto”: Sileno ebbro
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 27, 2017 Category: Endocrinology Source Type: research

Energy expenditure in the etiology of human obesity: spendthrift and thrifty metabolic phenotypes and energy-sensing mechanisms
AbstractThe pathogenesis of human obesity is the result of dysregulation of the reciprocal relationship between food intake and energy expenditure (EE), which influences daily energy balance and ultimately leads to weight gain. According to principles of energy homeostasis, a relatively lower EE in a setting of energy balance may lead to weight gain; however, results from different study groups are contradictory and indicate a complex interaction between EE and food intake which may differentially influence weight change in humans. Recently, studies evaluating the adaptive response of one component to perturbations of the ...
Source: Journal of Endocrinological Investigation - July 24, 2017 Category: Endocrinology Source Type: research

Peroxisome proliferator-activated receptor gamma expression in peripheral blood mononuclear cells and angiopoietin-like protein 4 levels in obese children and adolescents
ConclusionPPAR γ is decreased in childhood obesity and may be responsible for diminished ANGPTL4 levels. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 21, 2017 Category: Endocrinology Source Type: research

AT-101 acts as anti-proliferative and hormone suppressive agent in mouse pituitary corticotroph tumor cells
ConclusionAT-101 induces apoptosis in mouse pituitary corticotroph tumor cells. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 20, 2017 Category: Endocrinology Source Type: research

Acquired partial lipodystrophy after bone marrow transplant during childhood: a novel syndrome to be added to the disease classification list
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 18, 2017 Category: Endocrinology Source Type: research

Hyperuricemia is associated with an increased prevalence of paroxysmal atrial fibrillation in patients with type 2 diabetes referred for clinically indicated 24-h Holter monitoring
ConclusionsThis study shows for the first time that hyperuricemia is independently associated with an approximately fourfold increased risk of prevalent paroxysmal AF in patients with T2DM. These findings may partly explain the increased risk of permanent atrial fibrillation and cardiovascular death observed among patients with hyperuricemia. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 15, 2017 Category: Endocrinology Source Type: research

Does a male polycystic ovarian syndrome equivalent exist?
AbstractThe occurrence of a genetic background in the etiology of polycystic ovarian syndrome (PCOS) represents the rational basis to postulate the existence of a male PCOS equivalent. Hormonal and metabolic abnormalities have been described in male relatives of women with PCOS. These males also have a higher prevalence of early onset (
Source: Journal of Endocrinological Investigation - July 15, 2017 Category: Endocrinology Source Type: research

Diagnosis and management of treatment-refractory hypothyroidism: an expert consensus report
AbstractThere is a frequently encountered subset of hypothyroid patients who are refractory to standard thyroid hormone replacement treatment and require unexpectedly high doses of levothyroxine. In addition to clinical situations where hypothyroid patients are non-compliant, or where there is the possibility of excipient-induced disease exacerbation (gluten/celiac disease), therapeutic failure may be due to impaired absorption of the administered drug. The common approach to managing patients with unusual thyroxine needs is to escalate the dose of levothyroxine until targeted TSH levels are achieved. This approach can inc...
Source: Journal of Endocrinological Investigation - July 10, 2017 Category: Endocrinology Source Type: research

Use of testosterone gel compared to intramuscular formulation for puberty induction in males with constitutional delay of growth and puberty: a preliminary study
ConclusionsTo our knowledge this is the first study on use of TTG for pubertal activation on CDGP population. Our preliminary data confirm the efficacy of short-term Testosterone gel treatment to induce puberty compared to conventional treatment. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 10, 2017 Category: Endocrinology Source Type: research

Frequency of familial pituitary adenoma syndromes among patients with functioning pituitary adenomas in a reference outpatient clinic
ConclusionWe found a frequency of familial PA similar to that previously described, as well as a similar frequency ofAIP mutations among FIPA families. An active search of the affected family members was able to identify one case of Cushing ´s disease. Patients should be aware of pituitary disease’s clinical picture to identify possibly affected family members. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 8, 2017 Category: Endocrinology Source Type: research

Pretransplant diabetes mellitus predicts worse outcomes of liver transplantation: evidence from meta-analysis
ConclusionPreexisting DM predicts worse patient and graft survivals of LT. Concomitant HCV infection would further deteriorate this unfavorable impact. Given the high heterogeneities and the insufficient evidences, more studies are still warranted to support these observations. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 30, 2017 Category: Endocrinology Source Type: research

Role of contrast-enhanced ultrasound to define prognosis and predict response to biotherapy in pancreatic neuroendocrine tumors
AbstractPurposeThe incidence of neuroendocrine tumors (NETs) is progressively increasing. Most cases arise from the digestive system, where ileum, rectum and pancreas represent the commonest site of origin. Liver metastases are frequently detected at diagnosis or during the follow-up. Contrast-enhanced ultrasound (CEUS) is used in patients with pancreatic NETs (P-NETs) and liver metastases from P-NET but its role has not been standardized. The aim of this retrospective study was to investigate CEUS in patients with P-NETs and liver metastases from P-NET both as prognostic factor and predictor of response to therapy with so...
Source: Journal of Endocrinological Investigation - June 30, 2017 Category: Endocrinology Source Type: research

The effects of alpha-lipoic acid on diabetic myopathy
ConclusionTreatment with lipoic acid during 4 weeks has shown effects on the redistribution of muscle fibers, and can prevent atrophy in slow and fast diabetic muscle. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 28, 2017 Category: Endocrinology Source Type: research

Drug-induced obesity and its metabolic consequences: a review with a focus on mechanisms and possible therapeutic options
AbstractWeight gain is a common side effect of many widely used drugs. Weight gain of a few kilograms to an increase of 10% or more of initial body weight has been described. Not only the weight gain as such puts a burden on the health risks of the involved patients, the accompanying increase in the incidence of the metabolic syndrome, type 2 diabetes mellitus, and cardiovascular risk factors urges the caregiver to identify and to closely monitor the patients at risk. In this review, the different classes of drugs with significant weight gaining properties and the metabolic consequences are described. Specific attention is...
Source: Journal of Endocrinological Investigation - June 28, 2017 Category: Endocrinology Source Type: research

Evaluation of depressive mood and cognitive functions in patients with acromegaly under somatostatin analogue therapy
ConclusionThe present findings show that acromegaly negatively affects learning, attention, and planning. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 28, 2017 Category: Endocrinology Source Type: research

Action of three bioavailable antioxidants in orbital fibroblasts from patients with Graves ’ orbitopathy (GO): a new frontier for GO treatment?
ConclusionsOur study provides evidence in support of an antioxidant role of vitamin C,N-acetyl-l-cysteine and melatonin in orbital fibroblasts. Some of the effects of these compounds are exclusive to GO fibroblasts, whereas some other are observed also in control fibroblasts. Our observations provide a basis for a possible clinical use of these substances in patients with GO. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 27, 2017 Category: Endocrinology Source Type: research

Role of Jagged1-Notch pathway in thyroid development
AbstractThe zebrafish thyroid gland shows a unique pattern of growth. Despite the lack of a compact gland, the zebrafish thyroid tissue originates from the pharyngeal endoderm and the main genes involved in its patterning and early development are conserved between zebrafish and mammals. In recent years, the research has been focused to the search of novel candidate genes and environmental factors underlying congenital hypothyroidism. Among these, it has been demonstrated that the Notch signalling plays a central role during zebrafish thyroid development. In this review, we will provide an overview of the current knowledge...
Source: Journal of Endocrinological Investigation - June 26, 2017 Category: Endocrinology Source Type: research

Varicocele and semen quality: a retrospective case –control study of 4230 patients from a single centre
AbstractPurposeThe aim of the present study is to assess impairment of spermatogenesis induced by varicocele in, to our knowledge, the largest single-centre caseload available to date.Materials and methodsWe conducted a retrospective study on 4230 consecutive patients attending our Department for andrological outpatient assessment and preconception check-ups between 2011 and 2014. A total of 2113 patients had varicocele (Group V), while the remaining 2117 were selected as the control group (Group C). All patients were divided into age classes (
Source: Journal of Endocrinological Investigation - June 24, 2017 Category: Endocrinology Source Type: research

The relationship between circulating adiponectin, leptin and vaspin with bone mineral density (BMD), arterial calcification and stiffness: a cross-sectional study in post-menopausal women
AbstractObjective To explore the relationship between circulating adiponectin, leptin and vaspin with bone mineral density (BMD), arterial stiffness and vascular calcification in post-menopausal women. We hypothesised that adipokines produced by adipose tissue may be mediators of bone and cardiovascular disease (CVD) and explain, in part, the observed association between osteoporosis and CVD.DesignWe studied 386 ambulant community dwelling postmenopausal women aged (mean [SD] 61 [6.4] years). BMD at the lumbar spine, femoral neck (FN), and total hip (TH), body composition; fat mass (FM) and lean mass (LM) as well as abdo...
Source: Journal of Endocrinological Investigation - June 23, 2017 Category: Endocrinology Source Type: research

Latero-cervical lymph node metastases (N1b) represent an additional risk factor for papillary thyroid cancer outcome
AbstractPurposePapillary thyroid carcinoma (PTC), the most common thyroid cancer histotype, has a good prognosis even when spread to the neck lymph node (LN). The prognostic role of LN metastases ’ location is still controversial. The aim of the present study was to evaluate the clinical relevance of the number and location of LN metastases at presentation in PTCs.MethodsThis retrospective study included a consecutive series of 1653 PTC patients followed for a mean period of 5.9  years in a referral thyroid cancer clinic. All patients have undergone thyroidectomy with the dissection of at least six LNs. Accordin...
Source: Journal of Endocrinological Investigation - June 23, 2017 Category: Endocrinology Source Type: research

The association between circulating fetuin-A levels and type 2 diabetes mellitus risk: systematic review and meta-analysis of observational studies
The objective of this systematic review and meta-analysis of published observational studies was to investigate mean levels of fetuin-A in T2D patients and the relationship between blood fetuin-A levels and T2D risk.Materials and methodsPubMed, Embase, Google Scholar, Web of Science, and The Cochrane Library were systematically searched for potential relevant studies up to 1 December 2016. Natural logarithm-transformed estimate risks, standard mean differences on the basis of Hedges ’s adjusted g, and 95% confidence intervals (CIs) were calculated for all eligible studies and were combined to measure the pooled data ...
Source: Journal of Endocrinological Investigation - June 22, 2017 Category: Endocrinology Source Type: research