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Temporal trends in the starting of insulin therapy in type 2 diabetes in Italy: data from the AMD Annals initiative
ConclusionsIn this large cohort of T2D subjects, a progressively earlier start of insulin treatment was observed during a long observation period, suggesting a more proactive prescriptive approach. However, after 12  months from insulin prescription, in many patients, HbA1c levels were still out-of-target. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 5, 2024 Category: Endocrinology Source Type: research

Quality of care and clinical inertia in the management of cardiovascular risk factors in patients with type 1 and type 2 diabetes: data from AMD annals
ConclusionsIn conclusion, this study provides evidence of wide undertreatment of traditional cardiovascular risk factors among patients with diabetes included in AMD Annals Database. Undertreatment seems to be more pronounced in individuals with T1D compared to those with T2D and is frequently due to clinical inertia. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 4, 2024 Category: Endocrinology Source Type: research

Associations between abdominal obesity indices with hypertension in type 2 diabetes mellitus: Chinese visceral adiposity index
ConclusionWe found that CVAI was highly positively correlated with HTN in T2DM. Compared with other indices of abdominal obesity, such as WC, BMI, WHR, VAI, and LAP, the CVAI showed superior discriminative ability in T2DM complicated with HTN. Therefore, more attention should be paid to CVAI in T2DM. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 1, 2024 Category: Endocrinology Source Type: research

Features of patients and fracture risk in hypoparathyroidism; a single center study
ConclusionsThe relatively high BMD in patients with postsurgical hypoparathyroidism is not associated with lower fracture risk. Silent morphometric fractures are quite common in this group of patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 1, 2024 Category: Endocrinology Source Type: research

An overview of the use of the fracture risk assessment tool (FRAX) in osteoporosis
We present the characteristics of this tool and describe the use of thresholds (diagnostic and therape utic). We also present arguments as to why screening with FRAX should be considered. FRAX has several limitations which are described in this review. This review coincides with the release of a version, FRAXplus, which addresses some of these limitations. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 1, 2024 Category: Endocrinology Source Type: research

Serum biomarkers related to frailty predict negative outcomes in older adults with hip fracture
ConclusionsThese findings suggest that immunology biomarkers may represent useful predictors of clinical outcomes in hip fracture patients.Graphical abstract (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 1, 2024 Category: Endocrinology Source Type: research

Molecular study of the presence and transcriptional activity of HPV in semen
ConclusionsOur study suggests that searching for seminal HPV could be important in patients both with and without risk factors, especially in assisted reproduction where the risk of injecting sperm carrying HPV-DNA is possible. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 1, 2024 Category: Endocrinology Source Type: research

Cardiovascular evaluation and endothelial dysfunction in Cushing syndrome following remission: a prospective study
ConclusionsRemission in CS improves some cardiovascular parameters. ADMA and ET-1 are not reliable markers for endothelial dysfunction in CS. Metabolic improvements may not directly reflect on serum concentrations of TNF- α and IL-1β following remission of CS. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 1, 2024 Category: Endocrinology Source Type: research

Age effect on the shared etiology of glycemic traits and serum lipids: evidence from a Chinese twin study
ConclusionAcross the whole adulthood, genetic influences were consistently important for GLU, TC, TG, LDL-C and HDL-C, and age may affect the shared genetic influences between glycemic traits and serum lipids. Further studies are needed to elucidate the role of age in the interactions of genes related to glycemic traits and serum lipids. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 1, 2024 Category: Endocrinology Source Type: research

Causal effects of diabetic retinopathy on depression, anxiety and bipolar disorder in the European population: a Mendelian randomization study
ConclusionsThe results of the current MR analysis indicated a causal relationship between DR and BD in the European population, while there was no causal connection between DR and depression or anxiety. However, further research is needed to confirm these conclusions. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 1, 2024 Category: Endocrinology Source Type: research

Corticotropin-releasing hormone test predicts the outcome of unilateral adrenalectomy in primary bilateral macronodular adrenal hyperplasia
ConclusionsThree of four patients with PBMAH are surgically cured with U-Adx. Pre-operative hCRH testing can be useful to predict long-term remission rates. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 1, 2024 Category: Endocrinology Source Type: research

A bronze statue of the acromegalic giant Rigardus Rijnhout
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 1, 2024 Category: Endocrinology Source Type: research