Evaluation of serum hepcidin and iron levels in patients with PCOS: a case-control study
ConclusionDespite the differences in the serum levels of hepcidin between the two groups, no significant relation was observed between serum iron levels and hepcidin level in this group of patients. This implies the need for more comprehensive studies on gene expression in hepcidin and iron pathways using real-time and Western techniques to investigate more precisely serum hepcidin level and its relationship with the factors mentioned. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 7, 2017 Category: Endocrinology Source Type: research

Goiter in the “Venus at a mirror” (1615) by Peter Paul Rubens (1577–1640)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 6, 2017 Category: Endocrinology Source Type: research

Immunotherapy for type 1 diabetes
ConclusionsStem cell therapies achieved thus this far the most promising results, while immune ablation and standard immunosuppressants did not maintain the premises of preclinical results. The next step will be to generate a feasible and safe clinical approach in order to cure the thousands of patients affected by T1D. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 3, 2017 Category: Endocrinology Source Type: research

CO 2 laser for the treatment of diabetic foot ulcers with exposed bone. A consecutive series of type 2 diabetic patients
ConclusionsThe present pilot experience represents a novelty in this field showing a possible use of CO2-laser in the treatment of diabetic foot ulcers. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 3, 2017 Category: Endocrinology Source Type: research

Klinefelter syndrome: cardiovascular abnormalities and metabolic disorders
AbstractKlinefelter syndrome (KS) is one of the most common genetic causes of male infertility. This condition is associated with much comorbidity and with a lower life expectancy. The aim of this review is to explore more in depth cardiovascular and metabolic disorders associated to KS. KS patients have an increased risk of cerebrovascular disease (standardized mortality ratio, SMR, 2.2; 95% confidence interval, CI, 1.6 –3.0), but it is not clear whether the cause of the death is of thrombotic or hemorrhagic nature. Cardiovascular congenital anomalies (SMR, 7.3; 95% CI, 2.4–17.1) and the development of thrombo...
Source: Journal of Endocrinological Investigation - March 2, 2017 Category: Endocrinology Source Type: research

A likely cranial osteodystrophy (Paget ’s disease of bone) in a Precolumbian, Mesoamerican stone sculpture
AbstractThis short note illustrates facial and head features found in a stone sculpture of the ancient, Precolumbian period in a temple of the Mayan city of Copan (Honduras). The authors believe that this observation may support paleoanthropological evidence of Paget ’s disease of bone, an osteodystrophy described in the Mesoamerican Indian populations before the first millennium A.D. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 1, 2017 Category: Endocrinology Source Type: research

One-hour post-load plasma glucose levels associated with decreased insulin sensitivity and secretion and early makers of cardiometabolic risk
AbstractPurposeObese adults with normal glucose tolerance (NGT) but with 1-hour post-load plasma glucose (1hPG)  ≥ 155 mg/dl are at higher risk of developing type 2 diabetes (T2D) and cardiometabolic complications. Little information is available for the pediatric population, where recently, a lower cutoff, 132.5 mg/dl, has been suggested as being more sensitive to identify subjects at risk of T2D. Ou r aim was to assess whether obese Caucasian youth with 1hPG ≥ 132.5 mg/dl have worse insulin sensitivity and secretion and a worse cardiometabolic profile compared to obese youth with 1hPG 
Source: Journal of Endocrinological Investigation - February 28, 2017 Category: Endocrinology Source Type: research

The mystery of puberty initiation: genetics and epigenetics of idiopathic central precocious puberty (ICPP)
AbstractPuberty is a major developmental stage. Damaging mutations, considered as “mistakes of nature”, have contributed to the unraveling of the networks implicated in the normal initiation of puberty. Genes involved in the abnormal hypothalamic–pituitary–gonadal (HPG) axis development, in the normosmic idiopathic hypogonadotropic hypogonadism (nIHH), in the X-linked or autosomal forms of Kallmann syndrome and in precocious puberty have been identified (GNRH1, GNRHR, KISS1, GPR54, FGFR1, FGF8, PROK2, PROKR2, TAC3, TACR3, KAL1, PROK2, PROKR2, CHD7, LEP, LEPR, PC1, DAX1, SF-1, HESX-1, LHX3, PROP-1). ...
Source: Journal of Endocrinological Investigation - February 28, 2017 Category: Endocrinology Source Type: research

Antitumor activity of interferon- β1a in hormone refractory prostate cancer with neuroendocrine differentiation
ConclusionsRecombinant IFN- β1a (Rebif) showed a potent in vitro anti-proliferative activity in androgen-resistant prostate cancer cells, and it could represent a promising tool for the treatment of this tumor. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 28, 2017 Category: Endocrinology Source Type: research

A rare case of spontaneous Cushing disease remission induced by pituitary apoplexy
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 28, 2017 Category: Endocrinology Source Type: research

Papillary carcinoma in struma ovarii
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 28, 2017 Category: Endocrinology Source Type: research

Predictors of electrocardiographic abnormalities in type 1 Diabetes: the Wisconsin Epidemiologic Study of Diabetic Retinopathy
ConclusionsThe development of new ECG abnormalities is common in type 1 diabetes. Older age and HDL cholesterol are independent risk factors for developing new ECG abnormalities. Further research is needed to determine whether routine ECG screening is indicated in people with type 1 diabetes to identify those with underlying subclinical coronary heart disease. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 28, 2017 Category: Endocrinology Source Type: research

Daily life reflections of acromegaly guidelines
ConclusionsAlthough there were subtle differences, clinical practice guidelines were usually followed among Turkish endocrinologists. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 28, 2017 Category: Endocrinology Source Type: research

Diagnostic assessment of intraoperative cytology for papillary thyroid carcinoma: using a decision tree analysis
ConclusionsOur study suggests that IOCs using nuclear features and additional figures could be useful with decreasing the likelihood of inconclusive results. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 28, 2017 Category: Endocrinology Source Type: research

Risk of malignant neoplasms in acromegaly: a case –control study
ConclusionsMalignant neoplasms are significantly more common in patients with acromegaly. Particularly, risk of thyroid cancer was increased over fivefold. Systematic screening for neoplastic diseases should be important part of follow-up in these patients. Further case –control studies are strongly indicated to evaluate which neoplasms are more common in acromegalic patients and what is the exact risk of malignancy. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 28, 2017 Category: Endocrinology Source Type: research

Gynecomastia in the Ancient Egypt limestone statue of Hemiunu, the architect of the Great Pyramid of Giza (fl. 2570 BC)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 28, 2017 Category: Endocrinology Source Type: research

Erratum to: Effects of nutraceuticals on quality of life and sexual function of perimenopausal women
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 28, 2017 Category: Endocrinology Source Type: research

First-line screening tests for Cushing ’s syndrome in patients with adrenal incidentaloma: the role of urinary free cortisol measured by LC-MS/MS
ConclusionsThe 1-mg DST at its lowest threshold presented high sensitivity in identifying CS, but its low specificity encourages us to consider UFC levels, measured with LC-MS/MS, to reduce false-positive test results. High UFC levels could also be considered as markers to stratify cardiovascular risk in patients with adrenal incidentaloma. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 27, 2017 Category: Endocrinology Source Type: research

Effect of metformin and oral contraceptives on polycystic ovary syndrome and IVF cycles
ConclusionThe present study established no positive role of metformin and OC use in increasing the treatment success in IVF/ICSI cycles in PCOS patients. It would be appropriate to limit the use of these agents with special indications such as decreasing insulin resistance or synchronizing follicular cohort. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 26, 2017 Category: Endocrinology Source Type: research

“La Monstrua Desnuda”: an artistic textbook representation of Prader–Willi syndrome in a painting of Juan Carreño de Miranda (1680)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 26, 2017 Category: Endocrinology Source Type: research

Correlation between pre-ramadan glycemic control and subsequent glucose fluctuation during fasting in adolescents with Type 1 diabetes
This report compares the continuous glucose monitoring (CGM) data during fasting in adolescents with T1DM according to their Pre-Ramadan diabetes control.MethodsChildren and adolescents with T1DM who intended to fast the month of Ramadan were asked to wear the CGM during fasting for a minimum of 3  days. Hypoglycemia, hyperglycemia, and severe hyperglycemia were identified as BG 300  mg/dL (16.7 mmol/L) respectively, while normoglycemia was identified as BG 70–200 mg/dL (3.9–11.1 mmol/L). Patients were categorized as well-controlled (Group 1) and poorly controlled (Group 2) if th...
Source: Journal of Endocrinological Investigation - February 25, 2017 Category: Endocrinology Source Type: research

Challenges in assessing personality of individuals with Gender Dysphoria with the SWAP-200
ConclusionThis paper facilitates a better clinical understanding of transgender people, and help clinicians to be more knowledgeable in the assessment of this heterogeneous population. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 24, 2017 Category: Endocrinology Source Type: research

The effect of parathyroid hormone (1 –84) treatment on serum bone morphogenetic protein 4 and vascular endothelial growth factor in postmenopausal women with established osteoporosis
ConclusionsPTH (1 –84) treatment increased serum levels of VEGF and BMP4 in postmenopausal women with severe osteoporosis. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 24, 2017 Category: Endocrinology Source Type: research

Emphasis on the early diagnosis of antithyroid drug-induced agranulocytosis: retrospective analysis over 16 years at one Chinese center
AbstractPurposeAntithyroid drug (ATD)-induced agranulocytosis is a rare but life-threatening adverse drug reaction that occurs in patients during the treatment of Graves ’ disease. We aimed to comprehensively examine data for patients with this rare complication and to improve the clinical safety of ATDs.MethodsWe retrospectively reviewed the medical records of 64 hospitalized patients diagnosed with ATD-induced agranulocytosis between 2000 and 2015.ResultsAgranulocytosis occurred in 52 (81.3%) patients within the first 3  months after initiation of ATD therapy. Fever (84.4%) and sore throat (82.8%) were the mos...
Source: Journal of Endocrinological Investigation - February 23, 2017 Category: Endocrinology Source Type: research

Sensitivity of various body indices and visceral adiposity index in predicting metabolic syndrome among Chinese patients with adult growth hormone deficiency
ConclusionIn conclusion, our study showed all adiposity measures of interest present themselves as easy and practical tools for use in population studies and clinical practice for evaluating MetS in AGDH and VAI was identified as the best in Chinese AGHD patients among them. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 22, 2017 Category: Endocrinology Source Type: research

Thyroid volume and serum calcitonin changes during pregnancy
ConclusionThis study confirms a prevalence of thyroid autoimmunity/hypertropinemia in 3 –5% of pregnant women and shows that serum CT does not change in relation to the transient increase in TV occurring during gestation. An adequate daily iodine supplementation might be particularly useful during pregnancy to limit the TSH increase and the resulting thyroid gland and nodule enlargem ent. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 21, 2017 Category: Endocrinology Source Type: research

Association of follicle-stimulating hormone receptor single nucleotide polymorphisms with fertility in Greek men
ConclusionsFSHR SNPs at positions c.-29, c.566, c.919, and c.2039 (c.-29G >  A, c.566C >  T, c.919A >  G, c.2039A >  G) do not appear to play specific roles in male infertility. Larger studies are needed to confirm these results. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 20, 2017 Category: Endocrinology Source Type: research

Thanks to Reviewers 2016
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 17, 2017 Category: Endocrinology Source Type: research

Circulating microRNAs and diabetes mellitus: a novel tool for disease prediction, diagnosis, and staging?
AbstractDiabetes is a complex, multifactorial group of metabolic diseases characterized by chronic hyperglycaemia due to pancreatic beta-cell dysfunction and/or loss. It is characterized by an asymptomatic and highly variable prodromic phase, which renders diabetes mellitus difficult to be predicted with sufficient accuracy. Despite several efforts in the identification and standardization of newly trustable. Biomarkers able to predict and follow-up diabetes and to specifically subtype its different forms, few of them have proven of clinical utility. Recently, a new class of endogenous non-coding small RNAs, namely microRN...
Source: Journal of Endocrinological Investigation - February 16, 2017 Category: Endocrinology Source Type: research

Ultrasound-guided fine-needle aspiration biopsy of thyroid nodules in patients on oral anticoagulants
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 16, 2017 Category: Endocrinology Source Type: research

Role of levothyroxine and vitamin E supplementation in the treatment of oxidative stress-induced injury and apoptosis of myocardial cells in hypothyroid rats
AbstractObjectiveTo explore the underlying mechanism and treatment of myocardial injury caused by hypothyroidism, we evaluated oxidative stress in serum and myocardial tissue of hypothyroid rats. The effect of levothyroxine (LT4) replacement therapy and vitamin E (VitE) supplementation on oxidative stress-induced injury and apoptosis of myocardial tissue is examined.MethodsMale Sprague-Dawley rats were divided into five groups: normal control group, propylthiouracil group (PTU group), LT4 treatment group (PTU  + LT4 group), vitamin E treatment group (PTU + VitE group), and combined treatment gro...
Source: Journal of Endocrinological Investigation - February 16, 2017 Category: Endocrinology Source Type: research

Erratum to: Effects of nutraceuticals on quality of life and sexual function of perimenopausal women
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 16, 2017 Category: Endocrinology Source Type: research

Influence of segmental body composition and adiposity hormones on resting metabolic rate and substrate utilization in overweight and obese adults
This study determined the relationship of total and segmental body composition and adiposity hormones with RMR and respiratory exchange ratio (RER) in overweight and obese adults.MethodsIn 49 men (n = 23) and premenopausal women (n = 26) [mean ± SD; age = 35.0 ± 8.9 years; body mass index (BMI) = 33.6 ± 5.2 kg·m−2; percent body fat (%fat)  = 40.0 ± 8.0%], RMR and RER were evaluated using indirect calorimetry. Total and segmental body composition [fat mas...
Source: Journal of Endocrinological Investigation - February 15, 2017 Category: Endocrinology Source Type: research

Short-term, supra-physiological rhGH administration induces transient DNA damage in peripheral lymphocytes of healthy women
ConclusionsThis pilot study showed that 3 weeks of short-term supra-physiological rhGH administration in healthy women induce a transient DNA damage and mitogenic impairment in PBL. The analysis of DNA damage should be explored as useful tool in monitoring the mid to long-term effects of high rhGH treatment or abuse. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 15, 2017 Category: Endocrinology Source Type: research

Endopoints for screening thyroid cancer in the Republic of Korea: thyroid specialists ’ perspectives
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 15, 2017 Category: Endocrinology Source Type: research

The role of point-of-care 3-hydroxybutyrate testing in patients with type 2 diabetes undergoing coronary angiography
AbstractPurposeKetone bodies, 3-hydroxybutyrate (3BOHB), and acetoacetate derive from increased free fatty acid beta-oxidation, thus reflecting marked insulin deprivation with or without decompensated diabetes. Objectives of this study were (1) to determine circulating levels of 3BOHB in patients with and without type 2 diabetes (T2DM), before and after an elective coronary angiography; (2) to detect 3BOHB modification during the procedure; (3) to study possible associations between 3BOHB and clinical parameters/outcomes.MethodsSixteen T2DM (72  ± 11 years) and 22 matched controls (71 &plus...
Source: Journal of Endocrinological Investigation - February 10, 2017 Category: Endocrinology Source Type: research

Pegvisomant in acromegaly: an update
ConclusionsPEG increasingly appears to be an effective and safe medical option for many patients not controlled by SRL but its use still needs to be optimized. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 6, 2017 Category: Endocrinology Source Type: research

Does early response to intravenous glucocorticoids predict the final outcome in patients with moderate-to-severe and active Graves ’ orbitopathy?
ConclusionsPatients who deteriorate at 6 weeks after ivGCs are unlikely to benefit from continuing ivGCs. Patients unresponsive at 6 weeks still have a significant possibility of improvement later. Accordingly, they may continue ivGC treatment, or, alternatively, possibly stop ivGCs and be switched to a second-line treatment. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 6, 2017 Category: Endocrinology Source Type: research

Long-term safety and efficacy of Omnitrope ® in adults with growth hormone deficiency: Italian interim analysis of the PATRO Adults study
ConclusionsThis study confirms the effectiveness and safety of Omnitrope® in adult patients with GHD in Italy. However, due to the limited size of the study population, these results need to be further confirmed by the global PATRO Adults study. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 3, 2017 Category: Endocrinology Source Type: research

The thyroid, the eyes and the gut: a possible connection
ConclusionIn this scenario, a Marie Sklodowska –Curie funded project INDIGO (http://www.indigo-iapp.eu/) is investigating the role of the gut bacteria in GD and GO pathogenesis. The gut is the first and the widest area of bacteria access, with the highest concentration of T cells in the human body and trained to react to microorganisms. Interestingly, all the environmental factors involved in GD and GO pathogenesis can alter the balance within the microorganisms located in the gut, and influence the immune system, in particular the proportions of regulatory Treg and inflammatory TH17 cells. It is hoped that investiga...
Source: Journal of Endocrinological Investigation - January 6, 2017 Category: Endocrinology Source Type: research

Auditory changes in acromegaly
AbstractObjective The aim of this study is to determine the changes involving auditory system in cases with acromegaly.Materials and methods Otological examinations of 41 cases with acromegaly (uncontrolledn = 22, controlledn = 19) were compared with those of age and gender-matched 24 healthy subjects. Whereas the cases with acromegaly underwent examination with pure tone audiometry (PTA), speech audiometry for speech discrimination (SD), tympanometry, stapedius reflex evaluation and otoacoustic emission tests, the co ntrol group did only have otological examination and PTA. Additionally, previously...
Source: Journal of Endocrinological Investigation - December 28, 2016 Category: Endocrinology Source Type: research

Is cardiorespiratory fitness impaired in PCOS women? A review of the literature
ConclusionsWomen with PCOS appear to be characterized by a reduced cardiopulmonary fitness. However, further research on this topic is needed. This information may hopefully help clinicians and exercise specialist in planning individualized exercise programs aimed at improving the metabolic and endocrine outcomes in these women. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 26, 2016 Category: Endocrinology Source Type: research

Disturbed nitric oxide and homocysteine production are involved in the increased risk of cardiovascular diseases in the F1 offspring of maternal obesity and malnutrition
ConclusionsMaternal malnutrition and obesity may increase the risk of the development of cardiovascular diseases in the offspring, especially the male ones. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 26, 2016 Category: Endocrinology Source Type: research

A woman by Breu J örg the Elder, Augsburg ca. 1515 Detroit Institute of Art
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 23, 2016 Category: Endocrinology Source Type: research

Depression contributing to dyslipidemic cardiovascular risk in the metabolic syndrome
ConclusionThe findings in this MetS sample suggest that triglycerides and depression severity are the key variables among MetS biomarkers in cross-sectionally associating with the fatal and total SCORE risk estimates in MetS. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 22, 2016 Category: Endocrinology Source Type: research

Remission of acromegaly after treatment withdrawal in patients controlled by cabergoline alone or in combination with octreotide: results from a multicenter study
ConclusionRemission of acromegaly after treatment withdrawal seems to be uncommon in patients controlled by cabergoline, either as monotherapy or in combination with octreotide. In the future, larger studies and/or meta-analysis will be necessary to accurately establish the remission rates of acromegaly after withdrawal of cabergoline with or without somatostatin analogs. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 22, 2016 Category: Endocrinology Source Type: research

Endpoints for screening thyroid cancer in the Republic of Korea: thyroid specialists ’ perspectives
AbstractCancer screening is aimed primarily at reducing deaths from the specific cancer. Thyroid-specific cancer mortality may be the most ambitious endpoint for obtaining estimates of screening effect. Numerous observations have accumulated over the years, indicating that thyroid cancer mortality endpoint has been difficult to study and is confounded by population heterogeneity, provision of randomization, and requirement of large cohorts with sufficiently long follow-up due to the excellent prognosis of the cancer. Accordingly, it may be important to reconsider how to best measure thyroid cancer screening efficacy. Recom...
Source: Journal of Endocrinological Investigation - December 21, 2016 Category: Endocrinology Source Type: research

Reduction of calprotectin and phosphate during testosterone therapy in aging men: a randomized controlled trial
AbstractObjectivesTo investigate the effect of testosterone treatment on biomarkers calprotectin, fibroblast growth factor 23 (FGF23), soluble Klotho, phosphate, calcium, parathyroid hormone, creatinine and estimated glomerular filtration rate.DesignRandomized, double-blinded, placebo-controlled study.SettingOdense Androgen Study —the effect of Testim and training in hypogonadal men.ParticipantsMen aged 60 –78 years old with a low normal concentration of free of bioavailable testosterone94  cm recruited from 2008 to 2009 (N = 48) by advertisement.InterventionParticipants were randomized to r...
Source: Journal of Endocrinological Investigation - December 19, 2016 Category: Endocrinology Source Type: research

Geniposide accelerates proteasome degradation of Txnip to inhibit insulin secretion in pancreatic β-cells
ConclusionsTxnip protein played an essential role in glucose uptake, metabolism and GSIS, and geniposide could accelerate the degradation via proteasome pathway in high-glucose-treated pancreatic INS-1 cells. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 19, 2016 Category: Endocrinology Source Type: research

Quercetin potentiates transdifferentiation of bone marrow mesenchymal stem cells into the beta cells in vitro
ConclusionsQuercetin has a strengthening effect on the differentiation of rat bone marrow mesenchymal stem cells into β-cells and increases insulin secretion from the differentiated β-cells in vitro. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 19, 2016 Category: Endocrinology Source Type: research