The relationship between hyperthyrotropinemia and metabolic and cardiovascular risk factors in a large group of overweight and obese children and adolescents
AbstractPurposeMild TSH elevations are frequently observed in obese patients, in the absence of any detectable thyroid disease. Our objective is to evaluate the relationship between the raised TSH levels and the biochemical and clinical consequences of obesity.MethodsThis is a retrospective cross-sectional study of a large population of obese children and adolescents. We evaluated 833 subjects (340 m, 493 f), aged 14.4  ± 2.5 (range 5.2–18.5) years, height SDS 0.27 ± 1.04 (−3.49–4.35), and BMI SDS 2.94 ± 0.59 (1.60–4.68). Body composition, free T4, ...
Source: Journal of Endocrinological Investigation - June 5, 2017 Category: Endocrinology Source Type: research

Can ARFI elastography be used to differentiate parathyroid from thyroid lesions?
AbstractObjectivesTo assess if elasticity score (ES) and shear wave velocity (SWV) measurement obtained using ARFI elastography can differentiate between parathyroid lesions and thyroid nodules.Materials and methodsARFI elastography was performed on patients with primary hyperparathyroidism or solid thyroid nodules who were being considered for surgery using virtual touch quantification and virtual touch imaging (VTI) software. Only patients with surgical histopathology (47 parathyroid lesions, 38 benign thyroid nodules and 55 malignant thyroid nodules) were included for final analysis. SWV and ES of the parathyroid and th...
Source: Journal of Endocrinological Investigation - May 31, 2017 Category: Endocrinology Source Type: research

Anti-thyroglobulin antibodies and risk of finding iodine avid metastases on post-radioactive iodine ablation scan in low-risk thyroid cancer patients
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 31, 2017 Category: Endocrinology Source Type: research

Epstein –Barr virus and thyroid cancer: the controversy remains
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 30, 2017 Category: Endocrinology Source Type: research

Low maternal circulating levels of vitamin D as potential determinant in the development of gestational diabetes mellitus
AbstractGestational diabetes mellitus (GDM), defined as any glucose intolerance with the onset or first recognition during pregnancy, is characterized by rising incidence, fostered by the worldwide increase of pathological nutritional status from young age. Clinical research has intended to identify potential risk factors, suggested improvements in screening strategies, and recommended the combination between promotion of an appropriate lifestyle before and during pregnancy and selected therapeutic approaches. Preventing pathological hyperglycemia could have several benefits, ranging from clinical side (reduction in the ri...
Source: Journal of Endocrinological Investigation - May 29, 2017 Category: Endocrinology Source Type: research

Histomorphometric changes following treatment for osteoporosis
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 26, 2017 Category: Endocrinology Source Type: research

Anti-tumoral effects of somatostatin analogs: a lesson from the CLARINET study
AbstractOctreotide and lanreotide, the first-generation somatostatin analogs, successfully control hormone hyperproduction, and related syndromes, in patients with acromegaly and neuroendocrine tumors. However, their anti-tumor effect, rather evident in large number of pituitary adenomas in acromegalic patients, has been hypothesized for a long time in patients with neuroendocrine tumors as well, although a significant tumor shrinkage has rarely been observed. However, the recent publication of the CLARINET study has strengthened the evidence, already emerged with the PROMID trial, that the long-term treatment with the fir...
Source: Journal of Endocrinological Investigation - May 26, 2017 Category: Endocrinology Source Type: research

Determination of spermatic vein reflux after varicocele repair helps to define the efficacy of treatment in improving sperm parameters of subfertile men
AbstractPurpose A continuous spermatic venous reflux (SVR) at colour Doppler ultrasound (CDU) is an evidence for varicocele, a frequent correlate for male subfertility. We explored whether SVR after left varicocele repair is predictive for changes in semen quality in subfertile men.Methods Blood hormones (FSH, LH, and total testosterone) and scrotal CDU were obtained in subfertile patients with left grade II or grade III varicocele on physical evaluation and a poor sperm quality. Semen analysis and CDU were re-evaluated 6  months after a retrograde internal spermatic vein scleroembolisation.ResultsThe retrospectiv...
Source: Journal of Endocrinological Investigation - May 25, 2017 Category: Endocrinology Source Type: research

Levothyroxine monotherapy versus levothyroxine and selenium combination therapy in chronic lymphocytic thyroiditis
This study aimed to assess whether combination of levothyroxine treatment and selenium (Se) supplementation results in improved therapeutic effects in CLT compared with levothyroxine monotherapy.MethodsAn open-label, randomized controlled study was performed in 60 CLT patients assigned to two groups. Levothyroxine group (LT) patients (n = 24) received levothyroxine alone for 3 months; meanwhile, the combination (LTSS) group (n = 36) was administered levothyroxine with selenium yeast capsule. Blood selenium concentrations, anti-thyroid peroxidase (TPO) and anti-thyroglobulin (Tg) antibody levels, an...
Source: Journal of Endocrinological Investigation - May 22, 2017 Category: Endocrinology Source Type: research

Hypothyroidism in hospitalized elderly patients: a sign of worse prognosis
AbstractPurposeOvert hypothyroidism has adverse clinical consequences and might worsen prognosis in critically ill elderly patients. However, the difficult interpretation of thyroid function tests (TFT) due to non-thyroidal illness (NTI) has led to discouragement of screening for thyroid dysfunction. Our aim was to determine the prevalence of TFT compatible with hypothyroidism and to study its influence on mortality among hospitalized elderly patients.MethodsIn this prospective study we consecutively included all patients ≥60 years admitted by the Internal Medicine Department to the hospital ward (n = 451...
Source: Journal of Endocrinological Investigation - May 22, 2017 Category: Endocrinology Source Type: research

The unresolved riddle of glucocorticoid withdrawal
AbstractGlucocorticoid (GC) therapy is the most common cause of adrenal insufficiency (AI). The real prevalence of AI after GC is unknown but it could involve more than 30% of patients. Some gene variation has been associated with the variability of hypothalamic-pituitary-adrenal (HPA) axis and this issue could contribute to the individual variation of adrenal function after GC treatment. Symptoms and signs of AI are nonspecific and frequently the diagnosis is delayed. Dosage, duration of treatment, administration route and serum cortisol value are not completely useful to predict AI. Clinical estimation of HPA suppression...
Source: Journal of Endocrinological Investigation - May 20, 2017 Category: Endocrinology Source Type: research

Benefits of a regular vs irregular rhythm-based training programme on physical fitness and motor skills in obese girls
ConclusionThese findings demonstrate that physical exercise at various tempos is useful for improving physical fitness, developing MS, and thus probably preventing obesity complications. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 20, 2017 Category: Endocrinology Source Type: research

Tall cell and diffuse sclerosing variants of papillary thyroid cancer: outcome and predicting value of risk stratification methods
AbstractPurposeTall cell (TCV) and diffuse sclerosing (DSV) variants are aggressive variants of papillary thyroid cancer (PTC). We compared the risk of recurrent/persistent disease in patients with TCV, DSV and classical PTC (cPTC) and evaluated the prognostic accuracy of initial vs. ongoing risk stratification.MethodsA consecutive series of DSV (n = 54), TCV (n = 72) and cPTC (n = 184) patients was retrospectively analyzed. TCV and DSV patients were first risk stratified for recurrent/persistent disease without considering the histotype as a risk factor and subsequently, 6–24 month...
Source: Journal of Endocrinological Investigation - May 20, 2017 Category: Endocrinology Source Type: research

Plasma vascular endothelial growth factor B levels are increased in patients with newly diagnosed type 2 diabetes mellitus and associated with the first phase of glucose-stimulated insulin secretion function of β-cell
AbstractPurposeTo detect plasma vascular endothelial growth factor B (VEGF-B) in individuals with different glucose tolerance and investigate the relationship between plasma VEGF-B levels and the first phase of glucose-stimulated insulin secretion.MethodsA cross-sectional study was conducted involving 45 patients with newly diagnosed type 2 diabetes mellitus (T2DM), 37 patients with impaired glucose regulation (IGR), and 39 Normal glucose tolerance (NGT) subjects, all of whom underwent intravenous glucose tolerance test. Plasma VEGF-B levels were assayed by ELISA. The first phase of insulin secretion was evaluated by ac...
Source: Journal of Endocrinological Investigation - May 18, 2017 Category: Endocrinology Source Type: research

Does thyroid dysfunction increase the risk of breast cancer? A systematic review and meta-analysis
ConclusionsOur meta-analysis illustrated that thyroid dysfunction may not be related to increased risk of breast cancer as well as the thyroid hormone substitution treatment did not reduce the incidence of breast cancer; while this study has some confounders that might weaken the results of this meta-analysis, we believe that the findings provide valuable information for stakeholders concerned with outcomes in patients with thyroid dysfunction. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 17, 2017 Category: Endocrinology Source Type: research

Anti-thyroglobulin antibodies do not significantly increase the risk of finding iodine avid metastases on post-radioactive iodine ablation scan in low-risk thyroid cancer patients
AbstractObjective Post-operative thyroglobulin (Tg) levels can predict the likelihood of residual cancer, including distant metastases, thereby influencing postsurgical treatment strategies even in patients with low-risk disease. Circulating anti-thyroglobulin antibodies (anti-Tg Abs) interfere with Tg measurement preventing this clinical use. It is not known if the presence of anti-Tg Abs predicts metastatic disease on post-therapy scan in patients with low-risk disease or if they should influence the use or dose of I-131 therapy. In the present study, we compare post-therapy scans in low-risk patients with and without ...
Source: Journal of Endocrinological Investigation - May 16, 2017 Category: Endocrinology Source Type: research

Testosterone insulin-like effects: an in vitro study on the short-term metabolic effects of testosterone in human skeletal muscle cells
ConclusionAll together our data indicate that testosterone through the activation of non-genomic pathways, participates in skeletal muscle glucose metabolism by inducing insulin-related effects. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 15, 2017 Category: Endocrinology Source Type: research

In memory of Professor Aldo Isidori
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 10, 2017 Category: Endocrinology Source Type: research

Chronic prostatitis and its detrimental impact on sperm parameters: a systematic review and meta-analysis
AbstractPurposeProstatitis is a very common urogenital disease of the male with prevalence ranging from 2.2 to 9.7% worldwide. Interestingly, some recent evidences have showed a significant association between chronic prostatitis (CP) and male infertility including a detrimental effect on sperm parameters, reduction of zinc concentration on semen sperm and production of anti-semen antibodies (ASAs). The aim of the current meta-analysis was to evaluate the association between CP and alteration of semen parameters.MethodsThis analysis was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-an...
Source: Journal of Endocrinological Investigation - May 9, 2017 Category: Endocrinology Source Type: research

Associations of blood glucose dynamics with antihyperglycemic treatment and glycemic variability in type 1 and type 2 diabetes
AbstractAimsThe dynamical structure of glucose fluctuation has largely been disregarded in the contemporary management of diabetes.MethodsIn a retrospective study of patients with diabetes, we evaluated the relationship between glucose dynamics, antihyperglycemic therapy, glucose variability, and glucose exposure, while taking into account potential determinants of the complexity index. We used multiscale entropy (MSE) analysis of continuous glucose monitoring data from 131 subjects with type 1 (n = 18), type 2 diabetes (n = 102), and 11 nondiabetic control subjects. We compared the MSE complexity index...
Source: Journal of Endocrinological Investigation - May 8, 2017 Category: Endocrinology Source Type: research

IUGR induced by maternal chronic inflammation: long-term effect on offspring ’s ovaries in rat model—a preliminary report
ConclusionsChronic maternal inflammation induced intrauterine growth restriction in offspring and a decrease in the proportion of follicles. This change might be due to premature apoptosis. These preliminary results suggest that maternal inflammation has a detrimental effect on the development of the female reproductive system of the offspring and thus, future fertility. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 6, 2017 Category: Endocrinology Source Type: research

Apparent biochemical thyrotoxicosis due to assay interference by high-dose biotin given for multiple sclerosis
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 6, 2017 Category: Endocrinology Source Type: research

Risk score model of type 2 diabetes prediction for rural Chinese adults: the Rural Deqing Cohort Study
ConclusionsOur non-invasive RS model can be used to identify individuals who are at high risk of T2DM as a simple, fast, and cost-effective tool for rural Chinese adults. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 4, 2017 Category: Endocrinology Source Type: research

Ultrasound characterization of insulin induced lipohypertrophy in type 1 diabetes mellitus
ConclusionsUltrasound scan can help identify and characterize the lipohypertrophic areas and this might be useful to improve glycemic control. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 27, 2017 Category: Endocrinology Source Type: research

Head of an old goitrous woman
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 25, 2017 Category: Endocrinology Source Type: research

Physical performance in newly diagnosed hypothyroidism: a pilot study
AbstractObjectiveHypothyroidism is complicated by neuromuscular symptoms (myalgias, slowness of movements, and tiredness) and signs (easy fatigability and cramps), which may have a negative impact on general well-being and quality of life. In a pilot, prospective, controlled study, we investigated the features of muscle dysfunction in hypothyroidism by disease questionnaire, biochemical measures, and physical performance tests.Materials and MethodsFifty-seven consecutive patients with newly diagnosed hypothyroidism were enrolled, 27 subclinical (S-Hypo) and 30 overt (O-Hypo). A series of 30 euthyroid subjects, with similar...
Source: Journal of Endocrinological Investigation - April 22, 2017 Category: Endocrinology Source Type: research

Transoral thyroidectomy: advantages and limitations
AbstractIn this opinion paper of theJournal of Endocrinological Investigation, leading experts in the field report on their current clinical experience with a novel approach for thyroid gland surgery, namely, “transoral thyroidectomy” (TOT). This feasible and novel surgical procedure does not require visible incisions and is, therefore, a truly scarless surgery. Patients meeting the following criteria can be considered as candidates for TOT: (a) an ultrasonographically (US) estimated thyroid diameter ≤10 cm; (b) US-estimated gland volume ≤45 mL; (c) nodule size ≤50 mm; (d) presence of a ...
Source: Journal of Endocrinological Investigation - April 21, 2017 Category: Endocrinology Source Type: research

Erratum to: Long-term safety and efficacy of Omnitrope ® in adults with growth hormone deficiency: Italian interim analysis of the PATRO Adults study
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 18, 2017 Category: Endocrinology Source Type: research

Influence of exercise intervention on gestational diabetes mellitus: a systematic review and meta-analysis
ConclusionsCompared to control intervention, exercise intervention was found to significantly reduce the incidence of gestational diabetes mellitus, but had no significant influence on preterm birth, gestational age at birth, glucose 2-h post-OGTT, birth weight, Apgar score less than 7, and preeclampsia. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 12, 2017 Category: Endocrinology Source Type: research

Association between low C-peptide and fragility fractures in postmenopausal women without diabetes
AbstractPurposeC-peptide has been shown to exert several, previously unknown, biological effects. A recent cross-sectional study demonstrated an association between low C-peptide serum levels and low lumbar bone density of postmenopausal women not affected by diabetes. To date, very little research attention has been directed toward the association between C-peptide and osteoporotic fractures. To contribute toward filling this gap, we investigated the association between C-peptide and fractures in postmenopausal women.MethodsA cohort of 133 non-diabetic postmenopausal women with and without a history of fractures was evalu...
Source: Journal of Endocrinological Investigation - April 11, 2017 Category: Endocrinology Source Type: research

Fluid intelligence, traits of personality and personality disorders in a cohort of adult KS patients with the classic 47, XXY karyotype
ConclusionsMost KS patients had average fluid intelligence. PD prevalence was higher than in the general population. Testosterone was not correlated with fluid intelligence, personality traits or PD, but a reduction in marital distress was observed in treated patients. This could suggest that testosterone therapy can improve physical symptoms and this effect could also improve relationship abilities and wellness awareness. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 11, 2017 Category: Endocrinology Source Type: research

The fight between a dwarf and a stork (Mosaic I century BC)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 11, 2017 Category: Endocrinology Source Type: research

Validation of the Italian Quality of Life in Short Stature Youth (QoLISSY) questionnaire
ConclusionIn conclusion, the Italian QoLISSY HrQoL-dimensions are comparable to other European countries. The psychometric quality of the Italian QoLISSY version is satisfactory and the instrument is ready for use in Italian patients and their parents. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 10, 2017 Category: Endocrinology Source Type: research

Prepubertal ultra-low-dose estrogen therapy is associated with healthier lipid profile than conventional estrogen replacement for pubertal induction in adolescent girls with Turner syndrome: preliminary results
ConclusionPrepubertal LE is associated with healthier lipid profile than CE in girls with TS. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 10, 2017 Category: Endocrinology Source Type: research

Quality of life after thyroid surgery
ConclusionsQuality of life increased after total thyroidectomy and statistically significant improvement was observed in late post-operative stage. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 10, 2017 Category: Endocrinology Source Type: research

Profiling of selenium absorption and accumulation in healthy subjects after prolonged l -selenomethionine supplementation
ConclusionsProlonged selenomethionine administration increases circulating blood selenium concentration and hydride generation atomic fluorescence spectroscopy enables its accurate quantification. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 9, 2017 Category: Endocrinology Source Type: research

Influence of vitamin D levels on the cardiovascular profile of hypogonadal men
AbstractPurpose A large body of evidence suggests a role for vitamin D in conditioning cardiovascular risk. Therefore, it can be hypothesized that vitamin D might also play a role in influencing the metabolic profile of hypogonadal men. In this work, we aimed at evaluating if any relationship exists between vitamin D levels and cardiovascular parameters in male hypogonadism.Methods Hypogonadal patients attending our andrology unit were retrospectively reviewed. Clinical and biochemical parameters were evaluated.Results103 patients were studied (51 non-diabetic and 52 diabetic subjects). Mean age of the whole sample was...
Source: Journal of Endocrinological Investigation - April 8, 2017 Category: Endocrinology Source Type: research

The effect of PPAR γ agonist on SGLT2 and glucagon expressions in alpha cells under hyperglycemia
ConclusionIn conclusion, PPAR γ agonist, troglitazone improved glucose transport SGLT2 dysfunction and subsequent glucagon dysregulation in alpha cell under hyperglycemia. Those effects were through the involvement of PI3K/pAkt signaling pathway. This study may add one more reason for the ideal combination of PPARγ agonist and SGLT2 inhibitor in clinical practice. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 8, 2017 Category: Endocrinology Source Type: research

“Metabolic and cardiovascular response to exercise in patients with type 1 diabetes”
ConclusionsPatients affected by T1DM have a worse exercise tolerance than normal subjects. The two groups differed by RER which can be greatly influenced by the substrate type utilized to produce energy. Because of the impaired carbohydrate utilization, T1DM subjects may use a larger amount of lipid substrates, such hypothesis could be strengthened by the lower lactate levels found in T1DM group at peak exercise. The lack of correlation between exercise tolerance and disease-related variables suggests that the alterations found could be independent from the glycemic levels. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 6, 2017 Category: Endocrinology Source Type: research

Binding of thyroglobulin (Tg) to the low-density lipoprotein receptor-associated protein (RAP) during the biosynthetic pathway prevents premature Tg interactions with sortilin
ConclusionsTg does not bind prematurely to sortilin because of its interaction with RAP during protein biosynthesis. These findings add new information to the knowledge of thyroid physiology. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 5, 2017 Category: Endocrinology Source Type: research

Association of established hypothyroidism-associated genetic variants with Hashimoto ’s thyroiditis
ConclusionsSH2B3 gene has previously been associated with susceptibility to several autoimmune diseases, whereasPDE8B has been associated with TSH levels and suggested to modulate thyroid physiology that may influence the manifestation of thyroid disease. Identified loci are novel and biologically plausible candidates for HT development and represent good basis for further exploration of HT susceptibility. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 5, 2017 Category: Endocrinology Source Type: research

A randomized, open-label, controlled trial to evaluate the antimicrobial and surgical effect of CO 2 laser treatment in diabetic infected foot ulcers: DULCIS (diabetic ulcer, CO 2 laser, and infections) study
ConclusionsDebridement of ulcers with CO2 laser significantly reduces bacterial load and fibrin-covered areas, and could be of help in the treatment of diabetic foot ulcer. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 4, 2017 Category: Endocrinology Source Type: research

Less is more: time to expand the indications for minimally invasive video-assisted parathyroidectomy
ConclusionMIVAP offers the ability to perform a neck exploration and/or an en bloc thyroid lobectomy without the need to convert to a standard cervicotomy. Therefore, it not only serves as a targeted parathyroid procedure but also a potential alternative to full neck exploration. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 3, 2017 Category: Endocrinology Source Type: research

Long-term blood glucose monitoring with implanted telemetry device in conscious and stress-free cynomolgus monkeys
ConclusionOur data demonstrate that the real-time telemetry method is reliable for monitoring blood glucose remotely and continuously in conscious, stress-free, and moving-free NHPs with the advantages highly valuable to diabetes research and drug discovery. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 1, 2017 Category: Endocrinology Source Type: research

In remembrance of Professor Mario Andreoli (1929 –2016)
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 30, 2017 Category: Endocrinology Source Type: research

Diabetic retinopathy: new therapeutic perspectives based on pathogenic mechanisms
AbstractDiabetic retinopathy (DR) is the leading cause of visual impairment and preventable blindness and represents a significant socioeconomic cost for healthcare systems worldwide. In early stages of DR the only therapeutic strategy that physicians can offer is a tight control of the risk factors for DR (mainly blood glucose and blood pressure). The currently available treatments for DR are applicable only at advanced stages of the disease and are associated with significant adverse effects. Therefore, new treatments for the early stages of DR are needed. However, in early stages of DR invasive treatments such as intrav...
Source: Journal of Endocrinological Investigation - March 29, 2017 Category: Endocrinology Source Type: research

Psychological characteristics of Italian gender dysphoric adolescents: a case –control study
AbstractPurposeGender dysphoria (GD) is associated with clinically significant distress and impairment in social, scholastic, and other important areas of functioning, especially when early onset is reported. The aim of the present study is to assess the psychopathological features associated with GD in adolescence, comparing a group of gender dysphoric adolescents (GDs) with a group of non-referred adolescents (NRs), in terms of body uneasiness, suicide risk, psychological functioning, and intensity of GD.MethodsA sample of 46 adolescents with GD and 46 age-matched NRs was evaluated (mean  ± SD age&th...
Source: Journal of Endocrinological Investigation - March 29, 2017 Category: Endocrinology Source Type: research

Utility of baseline serum phosphorus levels for predicting remission in acromegaly patients
AbstractPurposeHigh GH and IGF I levels increase tubular phosphate reabsorption in patients with acromegaly. We aimed to investigate the utility of serum phosphorus levels as an indicator for predicting chance of remission in acromegaly patients.DesignFifty-one patients (n: 51;F: 24,M: 27) with diagnosis of acromegaly were included in the study. Plasma IGF-1, Phosphorus (P) and nadir GH levels on oral glucose tolerance test (OGTT) at the time of diagnosis were analysed retrospectively. Patients were classified into two groups according to their plasma P levels;P ≤ 4.5 mg/dl (Group-1,n: 23, 45.1%),P&nb...
Source: Journal of Endocrinological Investigation - March 29, 2017 Category: Endocrinology Source Type: research

Do glucocorticoids induce addiction in humans?
(Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 25, 2017 Category: Endocrinology Source Type: research

Prevalence of thyroid dysfunction and its impact on cognition in older mexican adults: (SADEM study)
AbstractIntroductionSubclinical thyroid dysfunction is a possible risk factor for cognitive impairment in old age, but results are inconsistent. Aim of the present study was to evaluate the prevalence of thyroid dysfunction among older community-dwelling adults and to see whether thyroid function impacts the cognitive status of the elderly.MethodsWe included 1750 participants from the Study on Aging and Dementia in Mexico (SADEM). All subjects were evaluated clinically via specific interviews. TSH levels were analyzed by chemiluminescent immunometry assay. We classified participants into five thyroid state groups: (1) norm...
Source: Journal of Endocrinological Investigation - March 25, 2017 Category: Endocrinology Source Type: research